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MODEL1006230057
modified:
  W3 CDTF: Fri Jun 25 14:18:54 BST 2010
parameter: 333871
parameter: 333891
units def: 461093
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type: SBMLModel
notes: This a model from the article: A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction. Moore H, Li NK. J Theor Biol 2004 Apr 21;227(4):513-23 15038986 , Abstract: In this paper, we propose and analyse a mathematical model for chronic myelogenous leukemia (CML), a cancer of the blood. We model the interaction between naive T cells, effector T cells, and CML cancer cells in the body, using a system of ordinary differential equations which gives rates of change of the three cell populations. One of the difficulties in modeling CML is the scarcity of experimental data which can be used to estimate parameters values. To compensate for the resulting uncertainties, we use Latin hypercube sampling (LHS) on large ranges of possible parameter values in our analysis. A major goal of this work is the determination of parameters which play a critical role in remission or clearance of the cancer in the model. Our analysis examines 12 parameters, and identifies two of these, the growth and death rates of CML, as critical to the outcome of the system. Our results indicate that the most promising research avenues for treatments of CML should be those that affect these two significant parameters (CML growth and death rates), while altering the other parameters should have little effect on the outcome. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Moore H, Li NK. (2004) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, …
modified:
  W3 CDTF: Fri Jun 25 14:18:54 BST 2010
units def: 461117
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created:
  W3 CDTF: Fri Jun 25 14:18:54 BST 2010
creator:
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    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
modified:
  W3 CDTF: Fri Jun 25 14:18:54 BST 2010
parameter: 333886
rule: 333865
parameter: 333881
volume units: 290956
rule: 333868
parameter: 333877
parameter: 333893
units def: 461069
parameter: 333872
is described by: http://identifiers.org/pubmed/15038986
curated: false
compartment: 333861
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creator:
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    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 333883
parameter: 333882
units def: 461153
name: Moore2004_CML_TcellInteration
rule: 333869
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 333878
time units: 461191
parameter: 333873

333878
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units: dimensionless
value: 0.14
name: alpha_n
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value: 0.3
name: de
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name: day
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units: 461069
value: 0.23
name: dn
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333872
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value: 1510.0
name: Tn
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333892
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value: 0.0034
name: gamma_c
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