222494
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222501
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222498
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438392
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222487
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222506
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222511
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222521
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438416
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438356
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name: hour
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222491
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438404
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222519
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222499
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222502
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222516
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value: 0.1
name: d
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222512
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222522
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438368
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222526
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222509
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222503
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222518
constant: true
value: 0.5
name: gamma
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222496
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value: 0.0
name: m_7
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MODEL1006230052
rule: 222470
parameter: 222512
rule: 222474
units def: 438380
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 222526
parameter: 222509
area units: 291053
parameter: 222501
parameter: 222487
parameter: 222496
parameter: 222502
length unit: 076409
modified:
  W3 CDTF: Fri Jun 25 14:17:04 BST 2010
parameter: 222488
compartment: 222460
substance units: 178797
rule: 222485
rule: 222477
rule: 222473
parameter: 222527
parameter: 222514
rule: 222469
parameter: 222517
time units: 438404
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 222503
parameter: 222498
parameter: 222521
rule: 222468
parameter: 222504
parameter: 222522
parameter: 222497
parameter: 222506
parameter: 222492
type: SBMLModel
volume units: 290956
modified:
  W3 CDTF: Fri Jun 25 14:17:04 BST 2010
modified:
  W3 CDTF: Fri Jun 25 14:17:04 BST 2010
rule: 222480
parameter: 222491
rule: 222484
parameter: 222516
curated: false
parameter: 222519
rule: 222472
rule: 222479
rule: 222464
parameter: 222511
is described by: http://identifiers.org/pubmed/17251133
rule: 222475
parameter: 222518
rule: 222467
parameter: 222523
created:
  W3 CDTF: Fri Jun 25 14:17:04 BST 2010
units def: 438404
parameter: 222524
parameter: 222499
parameter: 222507
parameter: 222508
parameter: 222494
rule: 222483
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
name: Wodarz2007_CTLinflation_ModelB
parameter: 222493
units def: 438356
notes: This a model from the article: Dynamics of killer T cell inflation in viral infections. Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 , Abstract: Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published M…
parameter: 222513
rule: 222482
rule: 222478

222508
constant: false
value: NaN
name: R0
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222513
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438380
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name: first_order_rate_constant
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222492
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222527
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value: 0.1
name: ba
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222523
constant: true
value: 1.0E-6
name: pa
type: Parameter

222504
constant: false
value: 1.0
name: m_0
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222497
constant: false
value: 0.0
name: m_6
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222517
constant: true
value: 0.1
name: beta
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222507
constant: false
value: NaN
name: log_za
type: Parameter

222524
constant: true
value: 15.5
name: ca
type: Parameter

222514
constant: true
value: 10.0
name: lambda
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222488
constant: false
value: 0.0
name: y0
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222493
constant: false
value: 1.0
name: v
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222460
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment