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972893
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units: 416094
value: 0.006
name: k2
type: Parameter

416263
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972917
constant: true
units: 416070
value: 3110.0
name: k10
type: Parameter

416349
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kind: SECOND
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415961
unit: 415973
name: hour
type: SBMLUnitsDef

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unit: 416142
name: ml2_per_cell_molecule_hour
type: SBMLUnitsDef

972902
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units: 416130
value: 2.52E-9
name: k5
type: Parameter

972866
constant: true
units: 415961
value: NaN
name: time
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416057
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kind: SECOND
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972872
constant: false
value: 0.0
name: LT
type: Parameter

415985
unit: 415997
name: molecule_ml
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415937
unit: 415949
name: minute
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972842
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units: litre
size: 1.0
spatial dimensions: 3.0
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416190
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scale: 0
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kind: SECOND
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units: 416166
value: 8.38E-10
name: k1
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name: ml2
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972875
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value: 10000.0
name: RT
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unit: 416337
unit: 416325
name: per_molar_per_minute
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972908
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value: 0.35
name: k7
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unit: 416045
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value: 1000.0
name: Lm
type: Parameter

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units: 416313
value: 8.73E9
name: k9
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972869
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value: 500.0
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MODEL1006230046
units def: 415985
time units: 416361
rule: 972861
modified:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
substance units: 178797
parameter: 972902
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 416275
parameter: 972872
type: SBMLModel
compartment: 972842
rule: 972852
parameter: 972878
parameter: 972896
parameter: 972905
length unit: 076409
parameter: 972917
units def: 415961
area units: 291053
units def: 416009
parameter: 972890
units def: 416094
parameter: 972911
parameter: 972881
rule: 972855
is described by: http://identifiers.org/pubmed/12208611
units def: 416226
volume units: 290956
rule: 972864
units def: 416070
parameter: 972884
units def: 415937
rule: 972858
units def: 416033
units def: 416130
name: Webb2002_FasFasLsystem_Tumour
parameter: 972908
rule: 972849
units def: 416166
units def: 416361
parameter: 972875
modified:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
parameter: 972887
parameter: 972899
units def: 416251
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created:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
notes: This a model from the article: Cells behaving badly: a theoretical model for the Fas/FasL system in tumour immunology. Webb SD, Sherratt JA, Fish RG. Math Biosci 2002 Sep-Oct;179(2):113-29 12208611 , Abstract: One proposed mechanism of tumour escape from immune surveillance is tumour up-regulation of the cell surface ligand FasL, which can lead to apoptosis of Fas receptor (Fas) positive lymphocytes. Based upon this 'counterattack', we have developed a mathematical model involving tumour cell-lymphocyte interaction, cell surface expression of Fas/FasL, and their secreted soluble forms. The model predicts that (a) the production of soluble forms of Fas and FasL will lead to the down-regulation of the immune response; (b) matrix metalloproteinase (MMP) inactivation should lead to increased membrane FasL and result in a higher rate of Fas-mediated apoptosis for lymphocytes than for tumour cells. Recent studies on cancer patients lend support for these predictions. The clinical implications are two-fold. Firstly, the use of broad spectrum MMP inhibitors as anti-angiogenic agents may be compromised by their adverse effect on tumour FasL up-regulation. Also, Fas/FasL interactions may have an impact on the outcome of numerous ongoing immunotherapeutic trials since the final common pathway of all these approaches is the transduction of death signals within the tumour cell. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Webb SD, Sherratt JA, Fish RG. (2002) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please re…
parameter: 972869
curated: false
parameter: 972893
units def: 416313
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
modified:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 972914
units def: 416202
parameter: 972866
parameter: 972920

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unit: 416106
name: molecule_ml2_per_cell3_hour
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units: 416202
value: 500.0
name: m
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unit: 416263
name: per_hour
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416288
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972905
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units: 416070
value: 2244.0
name: k6
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415997
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type: SBMLUnit

972920
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units: 416251
value: 13.9
name: k11
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scale: 0
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972899
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units: 416251
value: 0.35
name: k4
type: Parameter

416070
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name: molecule_per_cell_hour
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416337
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972884
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value: 1000.0
name: Rm
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unit: 416214
name: cell_ml
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units: 416251
value: 5.9413
name: k3
type: Parameter

972887
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value: 0.0
name: SL
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value: 1.92E10
name: k8
type: Parameter

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name: per_minute
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