411544
unit: 411580
unit: 411568
unit: 411556
name: microg_l_day
type: SBMLUnitsDef

411374
unit: 411398
unit: 411386
name: L_nmol
type: SBMLUnitsDef

865496
constant: false
units: 411446
value: 467.0
name: RP_LH
type: Parameter

865546
constant: true
units: 411592
value: 8.21
name: kFSH_cl
type: Parameter

410994
exponent: 1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

411277
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

865556
constant: false
units: 411264
value: NaN
name: P4_dP
type: Parameter

411458
exponent: 1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

411216
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

865526
constant: false
units: 411446
value: 0.0
name: RP_FSH
type: Parameter

411204
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

865516
constant: false
units: 411470
value: 40.0
name: LH
type: Parameter

865506
constant: true
units: 411092
value: 360.0
name: Km_LH
type: Parameter

411042
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

865536
constant: true
units: 411374
value: 3.0
name: CFSH_P
type: Parameter

411410
unit: 411434
unit: 411422
name: L_ng2
type: SBMLUnitsDef

411143
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

411326
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

411018
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

411616
unit: 411628
name: time
type: SBMLUnitsDef

411362
exponent: -1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

411080
exponent: 2.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

411556
exponent: 1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

865544
constant: false
units: 411544
value: NaN
name: clear_FSH
type: Parameter

865558
constant: true
units: 410982
value: 2.9
name: dP
type: Parameter

865498
constant: false
units: 411507
value: NaN
name: syn_LH_E2_P4
type: Parameter

865530
constant: true
units: 411507
value: 4400.0
name: V_FSH
type: Parameter

411228
unit: 411252
unit: 411240
name: ng_ml
type: SBMLUnitsDef

411240
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

411030
unit: 411054
unit: 411042
name: U_L_day
type: SBMLUnitsDef

865460
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

865518
constant: true
units: litre
value: 2.5
name: v_dis
type: Parameter

411519
exponent: 1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

411116
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

865524
constant: false
units: 411507
value: NaN
name: rel_FSH_E2_P4_RP_FSH
type: Parameter

411494
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

865538
constant: true
units: 411410
value: 0.005
name: CFSH_E
type: Parameter

865504
constant: true
units: dimensionless
value: 8.0
name: h
type: Parameter

865550
constant: false
units: 411092
value: NaN
name: E2_dE
type: Parameter

411129
unit: 411167
unit: 411155
unit: 411143
name: ng_L_day
type: SBMLUnitsDef

411604
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

865564
constant: true
units: 410982
value: 2.0
name: dIh
type: Parameter

411155
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

411422
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

411338
unit: 411362
unit: 411350
name: L_ng
type: SBMLUnitsDef

865510
constant: true
units: 411592
value: 3.0
name: kLH_rel
type: Parameter

411179
unit: 411216
unit: 411204
unit: 411191
name: nmol_L_day
type: SBMLUnitsDef

411434
exponent: -2.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

411092
unit: 411116
unit: 411105
name: ng_L
type: SBMLUnitsDef

411350
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

411067
unit: 411080
name: day2
type: SBMLUnitsDef

865552
constant: true
units: 410982
value: 0.42
name: dE
type: Parameter

411290
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

411507
unit: 411531
unit: 411519
name: microg_day
type: SBMLUnitsDef

865522
constant: true
units: 411592
value: 14.0
name: kLH_cl
type: Parameter

411302
unit: 411326
unit: 411314
name: pmol_ml
type: SBMLUnitsDef

865532
constant: true
units: 411006
value: 1176.5
name: Ki_FSH_Ih
type: Parameter

411191
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

865542
constant: true
units: litre
value: 2.5
name: v_dis
type: Parameter

411252
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

411482
exponent: 1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

865512
constant: true
units: 411374
value: 0.024
name: CLH_P
type: Parameter

411568
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

411580
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

865562
constant: false
units: 411006
value: NaN
name: Ih_dIh
type: Parameter

865502
constant: true
units: 411507
value: 95900.0
name: V1_LH
type: Parameter

411398
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

411105
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

410982
unit: 410994
name: day
type: SBMLUnitsDef

411167
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

411446
unit: 411458
name: microg
type: SBMLUnitsDef

865494
constant: false
units: 411507
value: NaN
name: rel_LH_E2_P4_RP_LH
type: Parameter

865548
constant: false
units: 411092
value: NaN
name: E2
type: Parameter

MODEL1006230045
volume units: 290956
substance units: 178797
rule: 865482
length unit: 076409
units def: 411129
units def: 411446
rule: 865490
rule: 865463
units def: 411544
parameter: 865494
parameter: 865510
parameter: 865504
parameter: 865524
units def: 411264
parameter: 865544
units def: 411507
parameter: 865540
parameter: 865538
parameter: 865558
rule: 865468
rule: 865474
rule: 865484
rule: 865472
parameter: 865496
time units: 411616
units def: 411592
units def: 411338
curated: false
parameter: 865534
parameter: 865530
parameter: 865550
parameter: 865528
is described by: http://identifiers.org/pubmed/11035997
parameter: 865564
rule: 865466
units def: 411006
area units: 291053
rule: 865464
name: Schlosser2000_GlucoseInsulinFeedback_BetaCells
rule: 865470
rule: 865480
parameter: 865536
parameter: 865526
parameter: 865520
parameter: 865560
units def: 411092
units def: 411616
units def: 411302
compartment: 865460
parameter: 865512
parameter: 865502
parameter: 865532
parameter: 865522
units def: 411179
units def: 410982
parameter: 865508
notes: This a model from the article: Modeling insulin kinetics: responses to a single oral glucose administration or ambulatory-fed conditions. Lenbury Y, Ruktamatakul S, Amornsamarnkul S. Biosystems 2001 Jan;59(1):15-25 11226623 , Abstract: This paper presents a nonlinear mathematical model of the glucose-insulin feedback system, which has been extended to incorporate the beta-cells' function on maintaining and regulating plasma insulin level in man. Initially, a gastrointestinal absorption term for glucose is utilized to effect the glucose absorption by the intestine and the subsequent release of glucose into the bloodstream, taking place at a given initial rate and falling off exponentially with time. An analysis of the model is carried out by the singular perturbation technique in order to derive boundary conditions on the system parameters which identify, in particular, the existence of limit cycles in our model system consistent with the oscillatory patterns often observed in clinical data. We then utilize a sinusoidal term to incorporate the temporal absorption of glucose in order to study the responses in the patients under ambulatory-fed conditions. A numerical investigation is carried out in this case to construct a bifurcation diagram to identify the ranges of parametric values for which chaotic behavior can be expected, leading to interesting biological interpretations. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Lenbury Y, Ruktamatakul S, Amornsamarnkul S. (2000) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public do…
rule: 865492
units def: 411470
rule: 865486
parameter: 865556
parameter: 865516
parameter: 865506
parameter: 865546
parameter: 865552
parameter: 865542
parameter: 865562
type: SBMLModel
parameter: 865500
parameter: 865518
parameter: 865514
parameter: 865498
units def: 411067
units def: 411030
units def: 411228
parameter: 865554
units def: 411410
parameter: 865548
units def: 411374
rule: 865478

865554
constant: false
units: 411264
value: NaN
name: P4
type: Parameter

865508
constant: true
units: 411264
value: 26.0
name: Ki_LHP
type: Parameter

411628
exponent: 1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

411264
unit: 411290
unit: 411277
name: nmol_L
type: SBMLUnitsDef

865520
constant: false
units: 411544
value: NaN
name: clear_LH
type: Parameter

865540
constant: false
units: 411470
value: 150.0
name: FSH
type: Parameter

865560
constant: false
units: 411006
value: NaN
name: Ih
type: Parameter

411006
unit: 411018
name: U_L
type: SBMLUnitsDef

865534
constant: true
units: 411592
value: 45.0
name: kFSH_rel
type: Parameter

411314
exponent: 1.0
scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

411054
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

411531
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

411386
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

865500
constant: true
units: 411507
value: 1400.0
name: V0_LH
type: Parameter

865514
constant: true
units: 411338
value: 0.008
name: CLH_E
type: Parameter

411470
unit: 411494
unit: 411482
name: microg_l
type: SBMLUnitsDef

411592
unit: 411604
name: first_order_rate_constant
type: SBMLUnitsDef

865528
constant: false
units: 411507
value: NaN
name: syn_FSH_Ih
type: Parameter

given: Catherine
family: Lloyd

orgname: University of Auckland

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

orgname: University of Auckland

W3 CDTF: Fri Jun 25 14:11:07 BST 2010

W3 CDTF: Fri Jun 25 14:11:07 BST 2010

n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 14:11:07 BST 2010

W3 CDTF: Fri Jun 25 14:11:07 BST 2010