221532
constant: true
value: 0.2
name: K_x
type: Parameter

392487
unit: 392500
name: per_micromole
type: SBMLUnitsDef

221526
constant: true
value: 10.0
name: K_e
type: Parameter

221461
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

392500
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

392562
unit: 392574
name: per_second
type: SBMLUnitsDef

221556
constant: false
value: NaN
name: tau_h
type: Parameter

221561
constant: false
value: NaN
name: m_infinit
type: Parameter

221566
constant: false
value: NaN
name: RS_E
type: Parameter

392658
exponent: -2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

221502
constant: true
value: 1.25
name: k_deg
type: Parameter

221499
constant: true
value: 0.85
name: xi
type: Parameter

221565
constant: false
value: NaN
name: C_ER
type: Parameter

221516
constant: true
value: 0.185
name: epsilon_r
type: Parameter

221547
constant: false
value: 0.01
name: IP_3
type: Parameter

392586
unit: 392622
unit: 392610
unit: 392598
name: per_micromolar_per_second
type: SBMLUnitsDef

221506
constant: true
value: 5.0E7
name: PIP_2_T
type: Parameter

221512
constant: true
value: 2.781E-5
name: alpha
type: Parameter

392538
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

392610
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

221510
constant: true
value: 0.4
name: K_c
type: Parameter

221525
constant: true
value: 150.0
name: B_e
type: Parameter

221519
constant: true
value: 1.05
name: d_2
type: Parameter

221555
constant: false
value: 0.6155
name: h
type: Parameter

221509
constant: true
value: 0.001238
name: delta
type: Parameter

221535
constant: true
value: 575.0
name: eta_1
type: Parameter

221529
constant: true
value: 1200.0
name: K_ER
type: Parameter

221491
constant: true
value: 5.0
name: K_1
type: Parameter

221543
constant: false
value: 17000.0
name: RS
type: Parameter

392634
unit: 392670
unit: 392658
unit: 392646
name: micromolar_square_per_second
type: SBMLUnitsDef

221544
constant: false
value: 0.0
name: RS_p
type: Parameter

221496
constant: true
value: 0.03
name: k_p
type: Parameter

221550
constant: false
value: NaN
name: r_h
type: Parameter

221534
constant: true
value: 0.4
name: k_3
type: Parameter

221505
constant: true
value: 0.15
name: k_d
type: Parameter

392474
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

392448
unit: 392474
unit: 392461
name: per_micromolar
type: SBMLUnitsDef

392550
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

221540
constant: true
value: 67.0
name: C_T
type: Parameter

392646
exponent: 2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

221490
constant: true
value: 20000.0
name: R_T
type: Parameter

221528
constant: true
value: 120000.0
name: B_ER
type: Parameter

392435
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

221508
constant: true
value: 10.0
name: r_r
type: Parameter

221558
constant: false
value: NaN
name: h_infinit
type: Parameter

221538
constant: true
value: 45.0
name: eta_3
type: Parameter

392513
unit: 392550
unit: 392538
unit: 392526
name: flux
type: SBMLUnitsDef

392574
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

221500
constant: true
value: 100000.0
name: G_T
type: Parameter

221549
constant: false
value: 4.9997E7
name: PIP_2
type: Parameter

221563
constant: false
value: NaN
name: gamma
type: Parameter

221497
constant: true
value: 0.006
name: k_e
type: Parameter

221553
constant: false
value: 0.0961
name: C
type: Parameter

221520
constant: true
value: 0.943
name: d_3
type: Parameter

221514
constant: true
value: 5.0E-13
name: v
type: Parameter

392409
unit: 392435
unit: 392422
name: micromolar
type: SBMLUnitsDef

221493
constant: true
value: 100.0
name: K_2
type: Parameter

221559
constant: false
value: NaN
name: zeta
type: Parameter

221541
constant: true
value: 1000.0
name: L
type: Parameter

221522
constant: true
value: 0.0823
name: d_5
type: Parameter

392598
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

221523
constant: true
value: 0.2
name: a_2
type: Parameter

MODEL1006230039
parameter: 221512
volume units: 290956
parameter: 221561
parameter: 221541
parameter: 221553
parameter: 221517
parameter: 221544
parameter: 221556
rule: 221477
units def: 392448
rule: 221480
parameter: 221531
parameter: 221563
rule: 221474
rule: 221488
parameter: 221525
parameter: 221537
compartment: 221461
parameter: 221549
parameter: 221508
parameter: 221497
units def: 392487
rule: 221464
parameter: 221535
parameter: 221520
type: SBMLModel
parameter: 221547
units def: 392409
parameter: 221559
rule: 221471
parameter: 221514
parameter: 221490
parameter: 221506
rule: 221468
is described by: http://identifiers.org/pubmed/12782119
notes: This a model from the article: Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. Lemon G, Gibson WG, Bennett MR. J Theor Biol 2003 Jul 7;223(1):93-111 12782119 , Abstract: A mathematical account is given of the processes governing the time courses of calcium ions (Ca2+), inositol 1,4,5-trisphosphate (IP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)) in single cells following the application of external agonist to metabotropic receptors. A model is constructed that incorporates the regulation of metabotropic receptor activity, the G-protein cascade and the Ca2+ dynamics in the cytosol. It is subsequently used to reproduce observations on the extent of desensitization and sequestration of the P(2)Y(2) receptor following its activation by uridine triphosphate (UTP). The theory predicts the dependence on agonist concentration of the change in the number of receptors in the membrane as well as the time course of disappearance of receptors from the plasmalemma, upon exposure to agonist. In addition, the extent of activation and desensitization of the receptor, using the calcium transients in cells initiated by exposure to agonist, is also predicted. Model predictions show the significance of membrane PIP(2) depletion and resupply on the time course of IP(3) and Ca2+ levels. Results of the modelling also reveal the importance of receptor recycling and PIP(2) resupply for maintaining Ca2+ and IP(3) levels during sustained application of agonist. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Lemon G, Gibson WG, Bennett MR. (2003) - version=1.0 The original CellML model was created by: Wei Liu wliu052@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 …
parameter: 221546
parameter: 221558
parameter: 221540
parameter: 221552
parameter: 221496
length unit: 076409
parameter: 221516
rule: 221485
parameter: 221565
parameter: 221526
parameter: 221555
parameter: 221522
parameter: 221550
parameter: 221494
rule: 221465
parameter: 221562
units def: 392513
rule: 221473
name: Lemon2003_Ca2Dynamics
parameter: 221543
time units: 379353
parameter: 221499
units def: 392562
rule: 221476
rule: 221482
parameter: 221529
rule: 221479
rule: 221483
parameter: 221500
units def: 392586
parameter: 221513
curated: false
parameter: 221505
parameter: 221503
rule: 221486
parameter: 221532
area units: 291053
units def: 392634
substance units: 178797
parameter: 221510
parameter: 221538
parameter: 221493
parameter: 221509
parameter: 221523

221531
constant: true
value: 50.0
name: B_x
type: Parameter

392422
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

392461
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

221537
constant: true
value: 5.2
name: eta_2
type: Parameter

221562
constant: false
value: NaN
name: beta
type: Parameter

221517
constant: true
value: 0.13
name: d_1
type: Parameter

221546
constant: false
value: 0.0
name: G
type: Parameter

392526
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

221552
constant: false
value: NaN
name: rho_r
type: Parameter

392622
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

221513
constant: true
value: 6.02252E17
name: N_a
type: Parameter

221494
constant: true
value: 1.75E-4
name: k_r
type: Parameter

392670
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

221503
constant: true
value: 0.017
name: k_a
type: Parameter

ORG:
  orgname: The University of Auckland
n:
  given: Wei
  family: Liu

given: Wei
family: Liu

W3 CDTF: Fri Jun 25 13:43:43 BST 2010

given: Wei
family: Liu

ORG:
  orgname: The University of Auckland

W3 CDTF: Fri Jun 25 13:43:43 BST 2010

orgname: The University of Auckland

W3 CDTF: Fri Jun 25 13:43:43 BST 2010

W3 CDTF: Fri Jun 25 13:43:43 BST 2010