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value: NaN
name: tau
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388039
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201676
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units: dimensionless
value: 10.0
name: mu3
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201674
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388148
exponent: 1.0
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kind: MOLE
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201664
constant: true
units: dimensionless
value: 0.0
name: s1
type: Parameter

201662
constant: true
units: dimensionless
value: 2.0E-7
name: g1
type: Parameter

201670
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units: dimensionless
value: 1.0
name: a
type: Parameter

201679
constant: true
units: dimensionless
value: 1000.0
name: g3
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388063
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kind: SECOND
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388027
unit: 388039
name: day
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201680
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units: dimensionless
value: 0.0
name: s2
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388160
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kind: LITRE
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201667
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units: dimensionless
value: 1.0
name: y
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201658
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units: dimensionless
value: 0.03
name: mu2
type: Parameter

201677
constant: true
units: dimensionless
value: 5.0
name: p2
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388112
exponent: -1.0
scale: -6
multipler: 1.0
kind: LITRE
type: SBMLUnit

388100
unit: 388124
unit: 388112
name: flux
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388051
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name: first_order_rate_constant
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388088
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scale: -6
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kind: LITRE
type: SBMLUnit

201665
constant: false
units: dimensionless
value: NaN
name: x
type: Parameter

201661
constant: true
units: dimensionless
value: 0.1245
name: p1
type: Parameter

388136
unit: 388160
unit: 388148
name: micromolar
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201649
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

MODEL1006230038
type: SBMLModel
parameter: 201658
substance units: 178797
modified:
  W3 CDTF: Fri Jun 25 13:43:22 BST 2010
curated: false
length unit: 076409
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area units: 291053
parameter: 201671
volume units: 290956
rule: 201655
parameter: 201664
parameter: 201662
notes: This a model from the article: Modeling immunotherapy of the tumor-immune interaction. Kirschner D, Panetta JC. J Math Biol 1998 Sep;37(3):235-52 9785481 , Abstract: A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune system to fight tumors. CD4+ T cells, the cells that orchestrate the immune response, use these cytokines as signaling mechanisms for immune-response stimulation as well as lymphocyte stimulation, growth, and differentiation. Because tumor cells begin as 'self', the immune system may not respond in an effective way to eradicate them. Adoptive cellular immunotherapy can potentially restore or enhance these effects. We illustrate through mathematical modeling the dynamics between tumor cells, immune-effector cells, and IL-2. These efforts are able to explain both short tumor oscillations in tumor sizes as well as long-term tumor relapse. We then explore the effects of adoptive cellular immunotherapy on the model and describe under what circumstances the tumor can be eliminated. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Kirschner D, Panetta JC. (1998) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database…
parameter: 201676
parameter: 201679
parameter: 201674
is described by: http://identifiers.org/pubmed/9785481
rule: 201652
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 388136
parameter: 201667
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
modified:
  W3 CDTF: Fri Jun 25 13:43:22 BST 2010
parameter: 201659
parameter: 201670
parameter: 201665
compartment: 201649
time units: 379353
parameter: 201668
parameter: 201680
parameter: 201677
units def: 388100
units def: 388027
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 201657
rule: 201653
name: Kirschner1998_Immunotherapy_Tumour
parameter: 201661
modified:
  W3 CDTF: Fri Jun 25 13:43:22 BST 2010
units def: 388076
parameter: 201673
created:
  W3 CDTF: Fri Jun 25 13:43:22 BST 2010

388076
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name: cells_per_microlitre
type: SBMLUnitsDef

201659
constant: true
units: dimensionless
value: 0.025
name: c
type: Parameter

201673
constant: true
units: dimensionless
value: 100000.0
name: g2
type: Parameter

388124
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scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

201671
constant: true
units: dimensionless
value: 1.0E-9
name: b
type: Parameter

201668
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units: dimensionless
value: 0.18
name: r2
type: Parameter