178838
constant: true
value: 50.0
name: Kc_p
type: Parameter

383675
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

383918
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

178874
constant: false
value: NaN
name: Jc_influx
type: Parameter

383968
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

383894
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

178834
constant: false
value: NaN
name: x_T
type: Parameter

178869
constant: false
value: NaN
name: J_HCO3
type: Parameter

178850
constant: true
value: 1247.0
name: Pb_p
type: Parameter

178881
constant: false
value: NaN
name: Js_bm
type: Parameter

383784
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

178854
constant: false
value: NaN
name: beta_p
type: Parameter

383821
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

383747
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

383870
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

178829
constant: true
value: 29.0
name: Cl_i
type: Parameter

178828
constant: true
value: 26.0
name: HCO3_e
type: Parameter

383663
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

383711
exponent: 1.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

383858
unit: 383894
unit: 383882
unit: 383870
name: nmol_per_s_per_cm2
type: SBMLUnitsDef

178837
constant: true
value: 172.0
name: K_I
type: Parameter

383906
unit: 383931
unit: 383918
name: mmol_per_cm2
type: SBMLUnitsDef

383760
unit: 383796
unit: 383784
unit: 383772
name: umol_per_s_per_cm2
type: SBMLUnitsDef

383796
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

178842
constant: true
value: 198.0
name: Kb_p
type: Parameter

178866
constant: false
value: NaN
name: x_pp
type: Parameter

383602
unit: 383614
name: umol
type: SBMLUnitsDef

383808
unit: 383846
unit: 383833
unit: 383821
name: mmol_per_s_per_cm2
type: SBMLUnitsDef

178885
constant: false
value: NaN
name: Ji_cm
type: Parameter

178833
constant: true
value: 1.0
name: x_Tmax
type: Parameter

383578
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

178865
constant: false
value: NaN
name: x_p
type: Parameter

178870
constant: false
value: NaN
name: J_Cl
type: Parameter

383944
unit: 383968
unit: 383956
name: nmol_per_cm2
type: SBMLUnitsDef

178861
constant: false
value: NaN
name: gamma_pp
type: Parameter

383626
unit: 383638
name: cm2
type: SBMLUnitsDef

178827
constant: false
value: 0.0
name: HCO3_i
type: Parameter

383956
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

383554
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

178841
constant: true
value: 50.0
name: Kc_pp
type: Parameter

178846
constant: true
value: 562.0
name: Pc_p
type: Parameter

383687
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

178886
constant: false
value: NaN
name: Js_cm
type: Parameter

178877
constant: false
value: NaN
name: Jo_bm
type: Parameter

383882
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

383931
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

383735
unit: 383747
name: per_s
type: SBMLUnitsDef

383833
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

178862
constant: false
value: NaN
name: sigma
type: Parameter

MODEL1006230037
parameter: 178881
parameter: 178857
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Jonna
    family: Terkildsen
rule: 178812
parameter: 178874
parameter: 178869
parameter: 178837
parameter: 178886
parameter: 178849
parameter: 178878
notes: This a model from the article: A mathematical model of the outer medullary collecting duct of the rat. Weinstein AM. Am J Physiol Renal Physiol 2000 Jul;279(1):F24-45 10894785 , Abstract: A mathematical model of the outer medullary collecting duct (OMCD) has been developed, consisting of alpha-intercalated cells and a paracellular pathway, and which includes Na(+), K(+), Cl(-), HCO(3)(-), CO(2), H(2)CO(3), phosphate, ammonia, and urea. Proton secretion across the luminal cell membrane is mediated by both H(+)-ATPase and H-K-ATPase, with fluxes through the H-K-ATPase given by a previously developed kinetic model (Weinstein AM. Am J Physiol Renal Physiol 274: F856-F867, 1998). The flux across each ATPase is substantial, and variation in abundance of either pump can be used to control OMCD proton secretion. In comparison with the H(+)-ATPase, flux through the H-K-ATPase is relatively insensitive to changes in lumen pH, so as luminal acidification proceeds, proton secretion shifts toward this pathway. Peritubular HCO(3)(-) exit is via a conductive pathway and via the Cl(-)/HCO(3)(-) exchanger, AE1. To represent AE1, a kinetic model has been developed based on transport studies obtained at 38 degrees C in red blood cells. (Gasbjerg PK, Knauf PA, and Brahm J. J Gen Physiol 108: 565-575, 1996; Knauf PA, Gasbjerg PK, and Brahm J. J Gen Physiol 108: 577-589, 1996). Model calculations indicate that if all of the chloride entry via AE1 recycles across a peritubular chloride channel and if this channel is anything other than highly selective for chloride, then it should conduct a substantial fraction of the bicarbonate exit. Since both luminal membrane proton pumps are sensitive to small changes in cytosolic pH, variation in density of either AE1 or peritubular anion conductance can modulate OMCD proton secretory rate. With respect to the OMCD in situ, available buffer is predicted to be abundant, including delivered HCO(3)(-) and HPO(4)(2-), as well as peritubular NH(3). Thus,…
parameter: 178861
is described by: http://identifiers.org/pubmed/10894785
parameter: 178854
rule: 178797
parameter: 178841
parameter: 178870
rule: 178821
parameter: 178833
parameter: 178882
parameter: 178858
rule: 178818
units def: 383735
parameter: 178845
units def: 383760
rule: 178800
name: Weinstein2000_OMCD
rule: 178805
type: SBMLModel
parameter: 178838
units def: 383699
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Jonna
    family: Terkildsen
rule: 178808
substance units: 178797
parameter: 178850
units def: 383626
units def: 383651
modified:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
created:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
parameter: 178827
parameter: 178830
length unit: 076409
rule: 178796
rule: 178814
parameter: 178842
rule: 178791
units def: 383858
units def: 383906
parameter: 178834
rule: 178822
rule: 178817
area units: 291053
parameter: 178846
volume units: 290956
rule: 178793
units def: 383602
units def: 383542
curated: false
modified:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
parameter: 178873
units def: 383808
parameter: 178885
rule: 178825
parameter: 178828
parameter: 178877
modified:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
units def: 383944
rule: 178801
units def: 383566
rule: 178813
parameter: 178829
parameter: 178862
compartment: 178787
rule: 178804
parameter: 178853
rule: 178809
parameter: 178866
rule: 178792
time units: 379353
parameter: 178865

178857
constant: false
value: NaN
name: beta_pp
type: Parameter

383614
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

178873
constant: false
value: NaN
name: Jb_influx
type: Parameter

178845
constant: true
value: 198.0
name: Kb_pp
type: Parameter

383651
unit: 383687
unit: 383675
unit: 383663
name: mM_per_s
type: SBMLUnitsDef

178849
constant: true
value: 61.0
name: Pc_pp
type: Parameter

383846
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

178787
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

383723
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

178830
constant: true
value: 114.0
name: Cl_e
type: Parameter

383772
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

178878
constant: false
value: NaN
name: Ji_bm
type: Parameter

383542
unit: 383554
name: mmol
type: SBMLUnitsDef

383638
exponent: 2.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

178882
constant: false
value: NaN
name: Jo_cm
type: Parameter

383699
unit: 383723
unit: 383711
name: cm_per_s
type: SBMLUnitsDef

383590
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

178858
constant: false
value: NaN
name: gamma_p
type: Parameter

178853
constant: true
value: 135.0
name: Pb_pp
type: Parameter

383566
unit: 383590
unit: 383578
name: mM
type: SBMLUnitsDef

given: Jonna
family: Terkildsen

orgname: The University of Auckland