092055
constant: false
value: NaN
name: FLA
type: Parameter

359788
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

092069
constant: false
value: NaN
name: ATP_energy
type: Parameter

092071
constant: true
value: 1.0
name: epsilon
type: Parameter

092065
constant: true
value: 0.228
name: F_max
type: Parameter

092075
constant: false
value: NaN
name: Efficiency
type: Parameter

359836
unit: 359861
unit: 359849
name: second_per_meter
type: SBMLUnitsDef

092032
constant: true
value: 10.0
name: f
type: Parameter

092038
constant: true
value: 1.0
name: Total_Tn
type: Parameter

092036
constant: true
value: 1.0
name: Ca_max
type: Parameter

092028
constant: true
value: 40.0
name: k_1
type: Parameter

359861
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

092061
constant: true
value: 1.0
name: L
type: Parameter

092051
constant: false
value: NaN
name: F
type: Parameter

359727
exponent: 1.0
scale: 3
multipler: 1.0
kind: GRAM
type: SBMLUnit

359776
exponent: 1.0
scale: 3
multipler: 1.0
kind: GRAM
type: SBMLUnit

359824
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

359800
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

092045
constant: false
value: 0.0
name: CB_on
type: Parameter

092041
constant: false
value: NaN
name: Ca_t
type: Parameter

359849
exponent: -1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

092025
constant: true
value: NaN
name: t
type: Parameter

092053
constant: false
value: 0.0
name: FTI
type: Parameter

359715
unit: 359751
unit: 359739
unit: 359727
name: force
type: SBMLUnitsDef

092040
constant: true
value: 1.0
name: Total_CB
type: Parameter

092067
constant: false
value: NaN
name: ATP
type: Parameter

092073
constant: true
value: 1.0
name: CumCB_on_end
type: Parameter

092057
constant: true
value: 1.0
name: phi
type: Parameter

092049
constant: false
value: 0.0
name: CumCB_off
type: Parameter

359751
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

092030
constant: true
value: 20.0
name: k_2
type: Parameter

092001
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

MODEL1006230032
parameter: 092045
parameter: 092061
notes: This a model from the article: Constancy and variability of contractile efficiency as a function of calcium and cross-bridge kinetics: simulation. Yamaguchi H, Takaki M, Matsubara H, Yasuhara S, Suga H. Am J Physiol 1996 Apr;270(4 Pt 2):H1501-8 8967394 , Abstract: We simulated myocardial Ca2+ (Ca) and cross-bridge (CB) kinetics to get insight into the experimentally observed constancy and variability of cardiac contractile efficiency in generating total mechanical energy under various inotropic and pathological conditions. The simulation consisted of a Ca transient, Ca association and dissociation rate constants of troponin C, and CB on and off rate constants. We evaluated sarcomere isometric twitch contractions at a constant muscle length. We assumed that each CB cycle hydrolyzes one ATP and that the force-length area (FLA) quantifies the total mechanical energy generated by CB cycles in a twitch contraction. FLA is a linear version of pressure-volume area, which quantifies the total mechanical energy of cardiac twitch contraction and correlates linearly with cardiac oxygen consumption (H. Suga, Physiol. Rev. 70: 247-277, 1990). The simulation shows that the contractile efficiency varies with changes in the Ca transient and Ca and CB kinetics except when they simultaneously speed up or slow down proportionally. These results point to possible mechanisms underlying the constancy and variability of cardiac contractile efficiency. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Yamaguchi H, Takaki M, Matsubara H, Yasuhara S, Suga H. (1996) - version=1.0 The original CellML model was created by: Geoffrey Nunns gnunns1@jhu.edu The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights t…
modified:
  W3 CDTF: Fri Jun 25 13:41:33 BST 2010
rule: 092016
substance units: 178797
parameter: 092043
parameter: 092063
parameter: 092025
modified:
  W3 CDTF: Fri Jun 25 13:41:33 BST 2010
volume units: 290956
length unit: 076409
parameter: 092028
parameter: 092069
parameter: 092053
parameter: 092073
parameter: 092034
rule: 092006
is described by: http://identifiers.org/pubmed/8967394
units def: 359764
units def: 359715
parameter: 092055
type: SBMLModel
compartment: 092001
parameter: 092071
curated: false
parameter: 092032
parameter: 092041
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
modified:
  W3 CDTF: Fri Jun 25 13:41:33 BST 2010
parameter: 092026
created:
  W3 CDTF: Fri Jun 25 13:41:33 BST 2010
units def: 359836
rule: 092020
time units: 348411
units def: 359812
rule: 092009
rule: 092007
parameter: 092065
rule: 092012
rule: 092022
parameter: 092030
rule: 092010
parameter: 092049
parameter: 092047
parameter: 092067
parameter: 092051
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
rule: 092005
parameter: 092059
area units: 291053
parameter: 092057
parameter: 092077
rule: 092014
parameter: 092038
parameter: 092040
rule: 092018
rule: 092023
name: Yamaguchi1996_MyocardialCa2
parameter: 092075
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
parameter: 092036

092077
constant: false
value: NaN
name: Economy
type: Parameter

359739
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

092063
constant: true
value: 0.0
name: L_0
type: Parameter

092034
constant: true
value: 10.0
name: g
type: Parameter

092026
constant: true
value: 0.1
name: D_Ca
type: Parameter

359812
unit: 359824
name: per_second
type: SBMLUnitsDef

359764
unit: 359800
unit: 359788
unit: 359776
name: energy
type: SBMLUnitsDef

092047
constant: false
value: 0.0
name: CumCB_on
type: Parameter

092059
constant: true
value: 1.0
name: s
type: Parameter

092043
constant: false
value: 0.0
name: TnCa
type: Parameter