604977
constant: true
value: 0.15
name: Kmf_PLB
type: Parameter

605007
constant: false
value: NaN
name: J_serca_sr
type: Parameter

604983
constant: true
value: 1110.0
name: Kmr_PLB
type: Parameter

314663
unit: 314687
unit: 314675
name: uM
type: SBMLUnitsDef

314807
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
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314831
unit: 314868
unit: 314856
unit: 314844
name: per_msec_per_uM2
type: SBMLUnitsDef

605003
constant: true
value: 0.00625
name: br_serca_sr
type: Parameter

314868
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

314711
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

604962
constant: true
value: 760.0
name: Ca_NSR
type: Parameter

314844
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

314795
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

605010
constant: false
value: 12.0
name: Ca_serca
type: Parameter

314735
unit: 314747
name: msec
type: SBMLUnitsDef

314892
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

314771
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

314819
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

MODEL1006230023
rule: 604952
type: SBMLModel
parameter: 604965
parameter: 604986
rule: 604959
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
parameter: 605007
rule: 604944
is described by: http://identifiers.org/pubmed/19414452
parameter: 604980
units def: 314831
units def: 314699
modified:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
parameter: 604971
modified:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
parameter: 604989
rule: 604955
length unit: 455845
units def: 314759
parameter: 604996
rule: 604940
compartment: 604936
parameter: 604961
parameter: 604999
parameter: 604962
rule: 604945
parameter: 604995
rule: 604951
units def: 314663
area units: 291053
created:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
modified:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
units def: 314783
units def: 314880
time units: 314880
volume units: 290956
substance units: 178797
parameter: 604992
parameter: 605006
name: Koivumaki2009_SERCAATPase_Standalone
rule: 604941
notes: This a model from the article: Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes. Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. Philos Transact A Math Phys Eng Sci 2009 Jun 13;367(1896):2181-202 19414452 , Abstract: When developing large-scale mathematical models of physiology, some reduction in complexity is necessarily required to maintain computational efficiency. A prime example of such an intricate cell is the cardiac myocyte. For the predictive power of the cardiomyocyte models, it is vital to accurately describe the calcium transport mechanisms, since they essentially link the electrical activation to contractility. The removal of calcium from the cytoplasm takes place mainly by the Na(+)/Ca(2+) exchanger, and the sarcoplasmic reticulum Ca(2+) ATPase (SERCA). In the present study, we review the properties of SERCA, its frequency-dependent and beta-adrenergic regulation, and the approaches of mathematical modelling that have been used to investigate its function. Furthermore, we present novel theoretical considerations that might prove useful for the elucidation of the role of SERCA in cardiac function, achieving a reduction in model complexity, but at the same time retaining the central aspects of its function. Our results indicate that to faithfully predict the physiological properties of SERCA, we should take into account the calcium-buffering effect and reversible function of the pump. This 'uncomplicated' modelling approach could be useful to other similar transport mechanisms as well. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. (2009) - version=1.0 The original CellML model was created by: Geoffrey Nunns gnunns1@jhu.edu The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) …
parameter: 605010
parameter: 604977
rule: 604958
parameter: 604983
parameter: 604968
parameter: 605003
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
parameter: 604974
curated: false
parameter: 605002
units def: 314735
rule: 604948

604986
constant: false
value: NaN
name: EC_50_fwd
type: Parameter

604992
constant: false
value: NaN
name: k_cyt_serca
type: Parameter

314759
unit: 314771
name: per_msec
type: SBMLUnitsDef

314687
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scale: 0
multipler: 1.0
kind: LITRE
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604996
constant: false
value: NaN
name: k_serca_sr
type: Parameter

604995
constant: false
value: NaN
name: k_serca_cyt
type: Parameter

314675
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

604961
constant: true
value: 0.25
name: Ca_cyt
type: Parameter

604965
constant: true
value: 0.0
name: CaMKII_reg
type: Parameter

604971
constant: true
value: 1.0
name: PSR
type: Parameter

604989
constant: false
value: NaN
name: EC_50_rev
type: Parameter

604968
constant: true
value: 47.0
name: SERCA_TOT
type: Parameter

604999
constant: false
value: NaN
name: k_sr_serca
type: Parameter

314856
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

314723
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

605006
constant: false
value: NaN
name: J_cyt_serca
type: Parameter

604974
constant: true
value: 0.15
name: Kmf_PLBKO
type: Parameter

605002
constant: false
value: NaN
name: br_cyt_serca
type: Parameter

604980
constant: true
value: 2500.0
name: Kmr_PLBKO
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314747
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

314699
unit: 314723
unit: 314711
name: per_uM2
type: SBMLUnitsDef

604936
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

314783
unit: 314819
unit: 314807
unit: 314795
name: uM_per_msec
type: SBMLUnitsDef

314880
unit: 314892
name: time
type: SBMLUnitsDef