363177
constant: true
value: 1792.0
name: t_off
type: Parameter

363159
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

296279
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

363190
constant: true
value: 24.04
name: tau_lamda
type: Parameter

296135
unit: 296147
name: minute
type: SBMLUnitsDef

296231
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

296219
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

296267
unit: 296279
name: time
type: SBMLUnitsDef

296147
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

363187
constant: true
value: 2.82
name: tau_I
type: Parameter

296207
exponent: 1.0
scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

296255
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

363183
constant: false
value: NaN
name: alpha
type: Parameter

296159
unit: 296183
unit: 296171
name: picomolar
type: SBMLUnitsDef

363181
constant: false
value: NaN
name: beta_I
type: Parameter

363175
constant: false
value: NaN
name: A
type: Parameter

363173
constant: false
value: 0.05
name: H1
type: Parameter

363178
constant: true
value: 6.51
name: A_max
type: Parameter

363176
constant: true
value: 1316.0
name: t_on
type: Parameter

296243
unit: 296255
name: first_order_rate_constant
type: SBMLUnitsDef

296171
exponent: 1.0
scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

363188
constant: true
value: 23.67
name: tau_C
type: Parameter

296195
unit: 296231
unit: 296219
unit: 296207
name: flux
type: SBMLUnitsDef

363184
constant: false
value: NaN
name: lamda
type: Parameter

363189
constant: true
value: 25.92
name: tau_alpha
type: Parameter

363182
constant: false
value: NaN
name: beta_C
type: Parameter

296183
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

MODEL1006230019
created:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
modified:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
units def: 296267
parameter: 363183
substance units: 178797
parameter: 363175
curated: false
parameter: 363178
units def: 296159
units def: 296195
parameter: 363173
rule: 363169
rule: 363170
modified:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
area units: 291053
volume units: 290956
parameter: 363188
parameter: 363182
parameter: 363190
parameter: 363174
name: Brown1997_PlasmaMelatoninLevels
units def: 296243
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 363165
rule: 363164
time units: 296267
parameter: 363187
rule: 363171
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
notes: This a model from the article: A mathematical model of diurnal variations in human plasma melatonin levels. Brown EN, Choe Y, Shanahan TL, Czeisler CA. Am J Physiol 1997 Mar;272(3 Pt 1):E506-16 9124558 , Abstract: Studies in animals and humans suggest that the diurnal pattern in plasma melatonin levels is due to the hormone's rates of synthesis, circulatory infusion and clearance, circadian control of synthesis onset and offset, environmental lighting conditions, and error in the melatonin immunoassay. A two-dimensional linear differential equation model of the hormone is formulated and is used to analyze plasma melatonin levels in 18 normal healthy male subjects during a constant routine. Recently developed Bayesian statistical procedures are used to incorporate correctly the magnitude of the immunoassay error into the analysis. The estimated parameters [median (range)] were clearance half-life of 23.67 (14.79-59.93) min, synthesis onset time of 2206 (1940-0029), synthesis offset time of 0621 (0246-0817), and maximum N-acetyltransferase activity of 7.17(2.34-17.93) pmol x l(-1) x min(-1). All were in good agreement with values from previous reports. The difference between synthesis offset time and the phase of the core temperature minimum was 1 h 15 min (-4 h 38 min-2 h 43 min). The correlation between synthesis onset and the dim light melatonin onset was 0.93. Our model provides a more physiologically plausible estimate of the melatonin synthesis onset time than that given by the dim light melatonin onset and the first reliable means of estimating the phase of synthesis offset. Our analysis shows that the circadian and pharmacokinetics parameters of melatonin can be reliably estimated from a single model. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Brown EN, Choe Y, Shanahan TL, Czeisler CA. (1997) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The Univ…
parameter: 363177
modified:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
units def: 296135
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
type: SBMLModel
parameter: 363181
parameter: 363189
rule: 363166
parameter: 363184
rule: 363163
compartment: 363159
parameter: 363176
length unit: 335510
is described by: http://identifiers.org/pubmed/9124558

363174
constant: false
value: 1.0
name: H2
type: Parameter