215124
unit: 215136
name: time
type: SBMLUnitsDef

214690
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

780145
constant: true
units: 215099
value: 0.693
name: k2
type: Parameter

214979
exponent: -2.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

214678
unit: 214702
unit: 214690
name: mm3_per_cells_per_day
type: SBMLUnitsDef

214594
exponent: -3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

780113
constant: true
units: 214871
value: 15.333
name: tau1
type: Parameter

780165
constant: true
units: 214787
value: 0.001
name: k12
type: Parameter

215099
unit: 215112
name: per_day
type: SBMLUnitsDef

780144
constant: true
units: dimensionless
value: 0.05
name: k1
type: Parameter

215039
exponent: 9.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

215051
exponent: -3.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

214871
unit: 214907
unit: 214895
unit: 214883
name: mm6_cells_per_pg3_day
type: SBMLUnitsDef

780112
constant: false
units: 214582
value: NaN
name: M_P
type: Parameter

214498
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

780096
constant: false
units: 214558
value: 50.0
name: F
type: Parameter

214546
exponent: -3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

780164
constant: true
units: 214787
value: 5.0
name: k11
type: Parameter

214847
exponent: -2.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

780125
constant: true
units: 214955
value: -0.1552
name: tau2
type: Parameter

780093
constant: false
units: 214486
value: 2.0
name: P
type: Parameter

215112
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

780157
constant: true
units: 214751
value: 0.015
name: k8
type: Parameter

214666
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

214967
exponent: 6.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

780088
constant: false
units: 214558
value: 200.0
name: phi_I
type: Parameter

780177
constant: true
units: 215099
value: 0.7
name: d6
type: Parameter

214715
unit: 214739
unit: 214727
name: mm3_per_microg
type: SBMLUnitsDef

214991
unit: 215015
unit: 215003
name: mm3_per_pg
type: SBMLUnitsDef

780124
constant: true
units: 214919
value: 0.0092
name: tau1
type: Parameter

214931
exponent: 9.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

214486
unit: 214510
unit: 214498
name: pg_per_mm3
type: SBMLUnitsDef

214534
exponent: 1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

780105
constant: true
units: 214823
value: 21.94
name: tau2
type: Parameter

780156
constant: true
units: 214751
value: 0.004
name: k7
type: Parameter

215027
unit: 215051
unit: 215039
name: mm9_per_microg3
type: SBMLUnitsDef

780087
constant: true
units: 214462
value: NaN
name: time
type: Parameter

780176
constant: true
units: 214678
value: 1.5E-5
name: d5
type: Parameter

215063
unit: 215087
unit: 215075
name: mm6_per_microg2
type: SBMLUnitsDef

214799
exponent: 1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

214835
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

MODEL1006230003
parameter: 780165
parameter: 780104
rule: 780073
units def: 215124
units def: 214678
parameter: 780160
parameter: 780148
area units: area
parameter: 780096
parameter: 780152
parameter: 780117
type: SBMLModel
rule: 780070
parameter: 780125
parameter: 780093
parameter: 780157
parameter: 780087
parameter: 780108
parameter: 780097
rule: 780072
parameter: 780112
parameter: 780100
units def: 214654
parameter: 780132
substance units: 178797
parameter: 780176
name: Waugh2006_WoundHealing_Diabetic_ModelB
rule: 780080
curated: false
units def: 214582
parameter: 780161
units def: 214486
parameter: 780153
parameter: 780128
rule: 780069
units def: 215027
units def: 214823
rule: 780085
parameter: 780136
parameter: 780105
units def: 214751
parameter: 780168
parameter: 780088
parameter: 780149
time units: 215124
units def: 215099
rule: 780071
parameter: 780113
parameter: 780145
parameter: 780133
units def: 214462
parameter: 780089
parameter: 780177
units def: 214991
rule: 780077
notes: This a model from the article: Modeling the effects of treating diabetic wounds with engineered skin substitutes. Waugh HV, Sherratt JA. Wound Repair Regen 2007 Jul-Aug;15(4):556-65 17650100 , Abstract: In this paper, a novel mathematical model of wound healing in both normal and diabetic cases is presented, focusing upon the effects of adding two currently available commercial engineered skin substitute therapies to the wound (Apligraf) and Dermagraft). Our work extends a previously developed model, which considers inflammatory and repair macrophage dynamics in normal and diabetic wound healing. Here, we extend the model to include equations for platelet-derived growth factor concentration, fibroblast density, collagen density, and hyaluronan concentration. This enables us to examine the variation of these components in both normal and diabetic wound healing cases, and to model the treatment protocols of these therapies. Within the context of our model, we find that the key component to successful healing in diabetic wounds is hyaluronan and that the therapies work by increasing the amount of hyaluronan available in the wound environment. The time-to-healing results correlate with those observed in clinical trials and the model goes some way to establishing an understanding of why diabetic wounds do not heal, and how these treatments affect the diabetic wound environment to promote wound closure. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Waugh HV, Sherratt JA. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public do…
parameter: 780120
parameter: 780172
units def: 214919
parameter: 780164
parameter: 780129
units def: 214715
units def: 215063
length unit: 335510
parameter: 780137
is described by: http://identifiers.org/pubmed/17650100
parameter: 780141
units def: 214522
parameter: 780169
parameter: 780116
compartment: 780064
rule: 780076
units def: 214955
rule: 780081
volume units: 950046
parameter: 780124
parameter: 780140
units def: 214787
parameter: 780156
parameter: 780109

214618
unit: 214642
unit: 214630
name: cells_per_pg_per_day
type: SBMLUnitsDef

780104
constant: true
units: 214871
value: -2.47
name: tau1
type: Parameter

214702
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

780141
constant: false
units: dimensionless
value: NaN
name: alpha
type: Parameter

780161
constant: true
units: 215099
value: 0.924
name: k10
type: Parameter

780128
constant: true
units: 214991
value: 0.6279
name: tau3
type: Parameter

780120
constant: true
units: 214582
value: 2.6593
name: tau4
type: Parameter

214955
unit: 214979
unit: 214967
name: mm6_per_pg2
type: SBMLUnitsDef

214654
unit: 214666
name: mm3_per_cells
type: SBMLUnitsDef

780092
constant: false
units: 214486
value: 6.0
name: T
type: Parameter

780169
constant: true
units: 215099
value: 9.1
name: d2
type: Parameter

780136
constant: true
units: 215063
value: 9.0E-7
name: tau2
type: Parameter

214919
unit: 214943
unit: 214931
name: mm9_per_pg3
type: SBMLUnitsDef

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

780108
constant: true
units: 214618
value: 6.41
name: tau3
type: Parameter

214739
exponent: -1.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

214751
unit: 214775
unit: 214763
name: pg_per_cells_per_day
type: SBMLUnitsDef

214606
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

780140
constant: true
units: dimensionless
value: 0.13
name: tau4
type: Parameter

215075
exponent: 6.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

780160
constant: true
units: 214751
value: 0.0015
name: k9
type: Parameter

214787
unit: 214811
unit: 214799
name: microg_per_cells_per_day
type: SBMLUnitsDef

780089
constant: false
units: 214558
value: 200.0
name: phi_R
type: Parameter

214823
unit: 214859
unit: 214847
unit: 214835
name: mm3_cells_per_pg2_day
type: SBMLUnitsDef

780121
constant: false
units: dimensionless
value: NaN
name: f_T
type: Parameter

780168
constant: true
units: 215099
value: 0.2
name: d1
type: Parameter

214895
exponent: -3.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

214474
exponent: 1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

215015
exponent: -1.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

780137
constant: true
units: 214715
value: -5.5E-4
name: tau3
type: Parameter

214582
unit: 214606
unit: 214594
name: cells_per_mm3_per_day
type: SBMLUnitsDef

780117
constant: true
units: 214618
value: 452.38
name: tau3
type: Parameter

214522
unit: 214546
unit: 214534
name: microg_per_mm3
type: SBMLUnitsDef

780153
constant: true
units: 214715
value: 4.0E-4
name: k6
type: Parameter

780064
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

780173
constant: true
units: 215099
value: 2.5
name: d4
type: Parameter

780097
constant: false
units: 214522
value: 10.0
name: C
type: Parameter

780149
constant: true
units: 214751
value: 0.07
name: k4
type: Parameter

214727
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

214558
unit: 214570
name: cells_per_mm3
type: SBMLUnitsDef

214907
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

780148
constant: true
units: 214654
value: 0.002
name: k3
type: Parameter

780101
constant: false
units: 214582
value: NaN
name: K_T
type: Parameter

780132
constant: false
units: dimensionless
value: NaN
name: g_C
type: Parameter

214763
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

780116
constant: true
units: 214823
value: -167.21
name: tau2
type: Parameter

214642
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

214943
exponent: -3.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

780152
constant: true
units: 214654
value: 0.0025
name: k5
type: Parameter

215087
exponent: -2.0
scale: -6
multipler: 1.0
kind: GRAM
type: SBMLUnit

214811
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

214775
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

780172
constant: true
units: 215099
value: 4.0
name: d3
type: Parameter

214630
exponent: -1.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

215003
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

214883
exponent: 6.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

214462
unit: 214474
name: day
type: SBMLUnitsDef

214570
exponent: -3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

214510
exponent: -3.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

780100
constant: false
units: 214522
value: 0.01
name: H
type: Parameter

780129
constant: true
units: dimensionless
value: 0.2527
name: tau4
type: Parameter

214859
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

215136
exponent: 1.0
scale: 0
multipler: 86400.0
kind: SECOND
type: SBMLUnit

780109
constant: true
units: 214582
value: 1.75
name: tau4
type: Parameter

780133
constant: true
units: 215027
value: -4.33E-10
name: tau1
type: Parameter

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 13:03:01 BST 2010

W3 CDTF: Fri Jun 25 13:03:01 BST 2010

W3 CDTF: Fri Jun 25 13:03:01 BST 2010

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 13:03:01 BST 2010