630299
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units: 204891
value: 0.0011
name: ksyn
type: Parameter

204807
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type: SBMLUnit

204831
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multipler: 60.0
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205036
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unit: 205048
name: cell_per_L_minute
type: SBMLUnitsDef

630302
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units: 204891
value: 0.15
name: kx
type: Parameter

630290
constant: true
units: 204891
value: 0.0138
name: kr
type: Parameter

204975
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scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

204783
unit: 204807
unit: 204795
name: picomolar
type: SBMLUnitsDef

630306
constant: true
units: 204963
value: 6.022E11
name: NA
type: Parameter

630282
constant: false
value: 1.0
name: Ci
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205023
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scale: 0
multipler: 1.0
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type: SBMLUnit

204999
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multipler: 60.0
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205072
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name: cell_per_L
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204879
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multipler: 60.0
kind: SECOND
type: SBMLUnit

630294
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units: 204915
value: NaN
name: kfe
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204903
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scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

630291
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units: 204915
value: NaN
name: kf
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204951
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scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

205096
unit: 205108
name: time
type: SBMLUnitsDef

630305
constant: true
units: 205011
value: 1.0E-14
name: Ve
type: Parameter

MODEL1006230001
units def: 204819
units def: 205036
units def: 205011
created:
  W3 CDTF: Fri Jun 25 13:00:33 BST 2010
parameter: 630299
parameter: 630288
parameter: 630296
rule: 630265
parameter: 630300
modified:
  W3 CDTF: Fri Jun 25 13:00:33 BST 2010
rule: 630271
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 630263
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 630281
parameter: 630287
parameter: 630294
parameter: 630285
parameter: 630305
volume units: 950046
units def: 205072
rule: 630272
parameter: 630278
is described by: http://identifiers.org/pubmed/11027188
parameter: 630297
notes: This a model from the article: Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response. Fallon EM, Lauffenburger DA. Biotechnol Prog 2000 Sep-Oct;16(5):905-16 11027188 , Abstract: Multisubunit cytokine receptors such as the heterotrimeric receptor for interleukin-2 (IL-2) are ubiquitous in hematopoeitic cell types of importance in biotechnology and are crucial regulators of cell proliferation and differentiation behavior. Dynamics of cytokine/receptor endocytic trafficking can significantly impact cell responses through effects of receptor down-regulation and ligand depletion, and in turn are governed by ligand/receptor binding properties. We describe here a computational model for trafficking dynamics of the IL-2 receptor (IL-2R) system, which is able to predict T cell proliferation responses to IL-2. This model comprises kinetic equations describing binding, internalization, and postendocytic sorting of IL-2 and IL-2R, including an experimentally derived dependence of cell proliferation rate on these properties. Computational results from this model predict that IL-2 depletion can be reduced by decreasing its binding affinity for the IL-2R betagamma subunit relative to the alpha subunit at endosomal pH, as a result of enhanced ligand sorting to recycling vis-a-vis degradation, and that an IL-2 analogue with such altered binding properties should exhibit increased potency for stimulating the T cell proliferation response. These results are in agreement with our recent experimental findings for the IL-2 analogue termed 2D1 [Fallon, E. M. et al. J. Biol. Chem. 2000, 275, 6790-6797]. Thus, this type of model may enable prediction of beneficial cytokine/receptor binding properties to aid development of molecular design criteria for improvements in applications such as in vivo cytokine therapies and in vitro hematopoietic cell bioreactors. This model was taken from the CellML repositor…
name: Fallon2000_IL2dynamics
rule: 630270
compartment: 630254
rule: 630266
parameter: 630303
units def: 204891
parameter: 630302
parameter: 630308
units def: 204963
parameter: 630280
substance units: 178797
parameter: 630293
parameter: 630284
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
length unit: 335510
rule: 630273
units def: 205096
rule: 630269
area units: area
units def: 204987
type: SBMLModel
rule: 630264
rule: 630275
time units: 205096
parameter: 630291
modified:
  W3 CDTF: Fri Jun 25 13:00:33 BST 2010
parameter: 630282
modified:
  W3 CDTF: Fri Jun 25 13:00:33 BST 2010
curated: false
parameter: 630290
rule: 630262
units def: 204915
units def: 204783
units def: 204843
parameter: 630306
parameter: 630279

204891
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name: first_order_rate_constant
type: SBMLUnitsDef

204939
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scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

630287
constant: false
units: 204783
value: 10.0
name: L
type: Parameter

204855
exponent: 1.0
scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

204927
exponent: -1.0
scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

630297
constant: true
units: 204987
value: 11.0
name: Vs
type: Parameter

630288
constant: false
units: 205072
value: 2.5E8
name: Y
type: Parameter

204987
unit: 204999
name: number_per_cell_minute
type: SBMLUnitsDef

205048
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scale: 0
multipler: 1.0
kind: LITRE
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630300
constant: true
units: 204891
value: 0.04
name: ke
type: Parameter

204819
unit: 204831
name: minute
type: SBMLUnitsDef

630293
constant: false
units: 204891
value: NaN
name: kre
type: Parameter

630278
constant: true
units: 204819
value: NaN
name: time
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630280
constant: false
value: 1.0
name: Cs
type: Parameter

630308
constant: true
units: dimensionless
value: 1.0
name: IL2
type: Parameter

205011
unit: 205023
name: L_per_cell
type: SBMLUnitsDef

630284
constant: false
value: 0.01
name: Li
type: Parameter

630254
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

205108
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multipler: 60.0
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205060
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multipler: 60.0
kind: SECOND
type: SBMLUnit

204795
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204867
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multipler: 1.0
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630296
constant: true
units: 204891
value: 0.007
name: kt
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630279
constant: false
value: 1500.0
name: Rs
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205084
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scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

630281
constant: false
value: 300.0
name: Ri
type: Parameter

630303
constant: true
units: 204891
value: 0.035
name: kh
type: Parameter

204843
unit: 204879
unit: 204867
unit: 204855
name: flux
type: SBMLUnitsDef

204915
unit: 204951
unit: 204939
unit: 204927
name: second_order_rate_constant
type: SBMLUnitsDef

204963
unit: 204975
name: number_per_picomole
type: SBMLUnitsDef

630285
constant: false
value: 1.0
name: Ld
type: Parameter