ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

200187
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name: mL_per_second2
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200175
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kind: SECOND
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685812
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value: NaN
name: V_lvf
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200271
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685795
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685874
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685845
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200223
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685808
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200103
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unit: 200127
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685825
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name: lambda_lvf
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685884
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value: NaN
name: Q_pul
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685835
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value: NaN
name: P_es_rvf
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200055
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kind: LITRE
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685722
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units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

200019
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685778
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name: R_tc
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685797
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685796
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name: B
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685844
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name: lambda_rvf
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200259
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kind: PASCAL
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685813
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value: NaN
name: P_lvf
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685807
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name: P_0_pcd
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200043
unit: 200055
name: per_mL
type: SBMLUnitsDef

685824
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value: 0.1203
name: P_0_lvf
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685834
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685777
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685783
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200283
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kind: LITRE
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685838
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value: NaN
name: P_ed_rvf
type: Parameter

685857
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value: NaN
name: P_pa
type: Parameter

685800
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value: NaN
name: tau
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200211
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685862
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name: V_d_pa
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200199
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200163
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scale: -3
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kind: LITRE
type: SBMLUnit

685843
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name: P_0_rvf
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685823
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name: V_d_lvf
type: Parameter

200007
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kind: PASCAL
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685882
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value: 0.0
name: V_d_vc
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200067
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unit: 200079
name: kPa_per_mL
type: SBMLUnitsDef

685784
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value: 8.0093E-5
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type: Parameter

685801
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value: 0.75
name: period
type: Parameter

200031
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685819
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name: P_ed_lvf
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685863
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name: P_pu
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685856
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value: 1.0
name: one
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685811
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value: 0.03
name: lambda_pcd
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685877
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name: P_vc
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685794
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value: NaN
name: e_t
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685883
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name: Q_sys
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685789
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value: 1.2189E-4
name: L_av
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199995
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200139
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685779
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name: R_pv
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200127
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685791
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685818
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200079
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685851
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685888
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685878
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200151
unit: 200175
unit: 200163
name: mL_per_second
type: SBMLUnitsDef

W3 CDTF: Mon Sep 27 18:18:29 BST 2010

685829
constant: false
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name: V_rvf
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685839
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name: E_es_rvf
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685803
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value: NaN
name: P_pcd
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200091
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685868
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685861
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MODEL1006230000
rule: 685730
rule: 685736
rule: 685734
parameter: 685873
type: SBMLModel
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rule: 685748
parameter: 685840
substance units: 178797
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units def: 200151
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parameter: 685785
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parameter: 685887
parameter: 685796
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parameter: 685874
parameter: 685783
parameter: 685784
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units def: 200067
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parameter: 685884
parameter: 685800
parameter: 685851
parameter: 685871
parameter: 685872
parameter: 685806
parameter: 685843
parameter: 685828
parameter: 685829
parameter: 685857
parameter: 685830
parameter: 685853
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parameter: 685824
parameter: 685825
parameter: 685845
rule: 685746
parameter: 685778
rule: 685729
units def: 200187
parameter: 685794
notes: This a model from the article: Minimal haemodynamic system model including ventricular interaction and valve dynamics. Smith BW, Chase JG, Nokes RI, Shaw GM, Wake G. Med Eng Phys 2004 Mar;26(2):131-9 15036180 , Abstract: Characterising circulatory dysfunction and choosing a suitable treatment is often difficult and time consuming, and can result in a deterioration in patient condition, or unsuitable therapy choices. A stable minimal model of the human cardiovascular system (CVS) is developed with the ultimate specific aim of assisting medical staff for rapid, on site modelling to assist in diagnosis and treatment. Models found in the literature simulate specific areas of the CVS with limited direct usefulness to medical staff. Others model the full CVS as a closed loop system, but they were found to be very complex, difficult to solve, or unstable. This paper develops a model that uses a minimal number of governing equations with the primary goal of accurately capturing trends in the CVS dynamics in a simple, easily solved, robust model. The model is shown to have long term stability and consistency with non-specific initial conditions as a result. An "open on pressure close on flow" valve law is created to capture the effects of inertia and the resulting dynamics of blood flow through the cardiac valves. An accurate, stable solution is performed using a method that varies the number of states in the model depending on the specific phase of the cardiac cycle, better matching the real physiological conditions. Examples of results include a 9% drop in cardiac output when increasing the thoracic pressure from -4 to 0 mmHg, and an increase in blood pressure from 120/80 to 165/130 mmHg when the systemic resistance is doubled. These results show that the model adequately provides appropriate magnitudes and trends that are in agreement with existing data for a variety of physiologically verified test cases simulating human CVS function. This model was taken from the CellML…
parameter: 685795
compartment: 685722
parameter: 685786
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rule: 685765
rule: 685761
rule: 685753
units def: 200247
rule: 685749
is described by: http://identifiers.org/pubmed/15036180
parameter: 685866
length unit: 335510
area units: area
parameter: 685811
parameter: 685883
parameter: 685862
parameter: 685882
parameter: 685802
units def: 199995
parameter: 685817
units def: 200043
parameter: 685818
parameter: 685803
parameter: 685839
parameter: 685877
parameter: 685850
rule: 685758
units def: 200223
parameter: 685780
parameter: 685868
parameter: 685813

685858
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name: E_es_pa
type: Parameter

685817
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value: 94.6812
name: V_lv
type: Parameter

685871
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name: P_ao
type: Parameter

685879
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value: 329.7803
name: V_vc
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685850
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value: 2.0
name: V_d_spt
type: Parameter

685889
constant: false
value: 190.0661
name: Q_tc
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685830
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name: P_rvf
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685820
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value: 2.8798
name: E_es_lvf
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200235
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685849
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685802
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685840
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685806
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200115
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685872
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685776
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685833
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685853
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685786
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685866
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name: E_es_pu
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685846
constant: true
value: NaN
name: V_spt
type: Parameter

685790
constant: true
value: 5.5
name: V_tot
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685890
constant: false
value: 0.0
name: Q_pv
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685780
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value: 0.1552
name: R_pul
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685873
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name: V_ao
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685814
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value: NaN
name: P_lv
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685785
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name: L_pv
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200247
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unit: 200271
unit: 200259
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685828
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name: V_0_lvf
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685887
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value: 245.5813
name: Q_mt
type: Parameter

685867
constant: false
value: 808.4579
name: V_pu
type: Parameter

685852
constant: true
value: 0.435
name: lambda_spt
type: Parameter

orgname: Auckland Bioengineering Institute, The Auckland University

given: Geoffrey
family: Nunns

orgname: Auckland Bioengineering Institute, The Auckland University

W3 CDTF: Mon Sep 27 18:18:29 BST 2010

W3 CDTF: Mon Sep 27 18:18:29 BST 2010

W3 CDTF: Wed Jun 23 14:38:09 BST 2010

given: Geoffrey
family: Nunns