736489
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

738615
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

733926
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

738530
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

metaid_0000188
kinetic law: 736779
product: 736767
reactant: 736755
notes: to regenerate the PIP2, DAG is phosphorylated by DAG kinase (dgk) to produce phosphatidic acid (PA). CDP-DAG synthase (CDS*) adds on CMP to phosphatidic acid.This product DGP-DAG, is the activator donor of the phosphatidyl group to inositol. The PI is phosphorylated by PI kinase and PIP kinase to yield PIP2.
fast: false
reversible: false
name: DAGdeg
type: Reaction

124210
units: metaid_0000003
value: 1.9161
name: k51
type: LocalParameter

739882
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

124251
units: metaid_0000003
value: 1.0
name: k1_2a
type: LocalParameter

124230
units: metaid_0000004
value: 0.105
name: k48
type: LocalParameter

736392
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

124183
units: metaid_0000004
value: 10.0
name: k72
type: LocalParameter

739737
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

736876
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

124211
units: metaid_0000004
value: 24.0
name: k51r
type: LocalParameter

metaid_0000189
kinetic law: 736815
product: 736803
reactant: 736791
fast: false
reversible: false
name: degRasGAPstar
type: Reaction

739158
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

735698
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

735890
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

737745
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

735758
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

124250
units: metaid_0000004
value: 1.67
name: k3r_2a
type: LocalParameter

739797
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

124231
units: metaid_0000003
value: 3.28
name: k47
type: LocalParameter

124184
units: metaid_0000003
value: 3.9
name: k71
type: LocalParameter

734166
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

739086
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000109
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.02
initial amount: NaN
in compartment: metaid_0000007
name: RGS4_1
type: Species

metaid_0000010
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.003791
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKP_MKP_PP
type: Species

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000030
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.027491
initial amount: NaN
in compartment: metaid_0000007
name: MKP_PP
type: Species

734239
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

metaid_0000129
kinetic law: 734058
product: 734046
product: 734034
reactant: 734022
notes: releasePLA2star_ERKPP
fast: false
reversible: false
name: releasePLA2star
type: Reaction

124185
units: metaid_0000004
value: 40.0
name: k71r
type: LocalParameter

734971
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

733792
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

737201
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

737117
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

735418
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

738156
stoichiometry: 1.0
species: metaid_0000090
type: SpeciesReference

738759
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

metaid_0000050
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.37759
initial amount: NaN
in compartment: metaid_0000007
name: cpx2AR_Gqtrimer
type: Species

metaid_0000108
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxRGS4_Gi_a_GTP_1
type: Species

738843
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

124389
units: metaid_0000004
value: 0.005
name: v6
type: LocalParameter

metaid_0000128
kinetic law: 734010
product: 733998
reactant: 733986
reactant: 733974
notes: Rafstarstar_bindsPP2A
fast: false
reversible: true
name: PP2Abinds_Rafstarstar
type: Reaction

124186
units: metaid_0000004
value: 0.01
name: k8_2a
type: LocalParameter

metaid_0000070
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 23.496
initial amount: NaN
in compartment: metaid_0000007
name: APC
type: Species

737831
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

124388
units: metaid_0000004
value: 6.67E-4
name: v62
type: LocalParameter

734543
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000107
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_a_GDP
type: Species

124275
units: metaid_0000003
value: 25.2
name: k13_2a
type: LocalParameter

734457
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

737165
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

738978
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000184
kinetic law: 736621
product: 736609
reactant: 736597
reactant: 736585
fast: false
reversible: true
name: PIP2_binds_PLA2_Ca
type: Reaction

734082
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

124234
units: metaid_0000005
value: 1.01
name: Km41
type: LocalParameter

733902
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

738554
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

738639
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

metaid_0000071
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.0539
initial amount: NaN
in compartment: metaid_0000007
name: AA
type: Species

124187
units: metaid_0000004
value: 0.105
name: k50
type: LocalParameter

metaid_0000032
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.15768
initial amount: NaN
in compartment: metaid_0000007
name: ERK
type: Species

124387
units: metaid_0000004
value: 0.00235
name: ke
type: LocalParameter

metaid_0000031
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.010356
initial amount: NaN
in compartment: metaid_0000007
name: ERK_P
type: Species

metaid_0000106
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_a_GTP
type: Species

124274
units: metaid_0000004
value: 1.0
name: k14r_2a
type: LocalParameter

738953
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

735674
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

124235
units: metaid_0000003
value: 24.0
name: k45
type: LocalParameter

739002
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

metaid_0000185
kinetic law: 736669
modifier: 736657
product: 736645
reactant: 736633
fast: false
reversible: false
name: AAfrom_PIP2_PLA2_Ca
type: Reaction

metaid_0000072
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.9064E-4
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca_AA
type: Species

737709
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

124273
units: metaid_0000003
value: 30.0
name: k14_2a
type: LocalParameter

734215
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

734995
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000186
kinetic law: 736718
modifier: 736706
product: 736694
reactant: 736682
fast: false
reversible: false
name: AAfrom_PLA2_Ca
type: Reaction

metaid_0000105
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_betagamma
type: Species

733684
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

739062
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

124232
units: metaid_0000004
value: 0.42
name: k47r
type: LocalParameter

metaid_0000073
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 4.5732E-4
initial amount: NaN
in compartment: metaid_0000007
name: PKC_AA
type: Species

737649
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

124189
units: metaid_0000003
value: 3.28
name: k49
type: LocalParameter

737310
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000034
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 4.9691E-4
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEKP_PP2A
type: Species

736912
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

735043
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

739351
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

ORG:
  orgname: Weill Medical College of Cornell University
n:
  given: Chiung-wen Violet
  family: Chang

124385
units: metaid_0000004
value: 0.1
name: k79
type: LocalParameter

738180
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

metaid_0000187
kinetic law: 736742
reactant: 736730
fast: false
reversible: false
name: IP3deg
type: Reaction

124272
units: metaid_0000004
value: 1.0
name: k12r_2a
type: LocalParameter

metaid_0000104
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_R1A_Gi
type: Species

738132
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000074
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0027563
initial amount: NaN
in compartment: metaid_0000007
name: PIP2_PLA2_Ca
type: Species

124233
units: metaid_0000004
value: 10.0
name: k41
type: LocalParameter

metaid_0000033
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.017627
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEKP_Rafstar
type: Species

734934
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

735188
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000161
kinetic law: 735590
product: 735578
reactant: 735565
reactant: 735553
notes: Gi_a_GTPbindsRGS
fast: false
reversible: true
name: RGSfor2A_binds_Gqa_GTP
type: Reaction

739026
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

736356
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

124343
units: metaid_0000004
value: 1.0
name: k24_2a
type: LocalParameter

metaid_0000075
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.072743
initial amount: NaN
in compartment: metaid_0000007
name: RasGEF
type: Species

739110
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

738663
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

737819
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000123
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: productX
type: Species

metaid_0000180
kinetic law: 736429
product: 736416
reactant: 736404
reactant: 736392
fast: false
reversible: true
name: DAGbindsPKC_Ca
type: Reaction

metaid_0000055
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_2AR
type: Species

736404
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

metaid_0000103
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxHT1AR_Gitrimer
type: Species

124363
units: metaid_0000005
value: 66.67
name: Km25_2a
type: LocalParameter

124279
units: metaid_0000003
value: 0.6
name: k21_2a
type: LocalParameter

metaid_0000141
kinetic law: 734617
product: 734605
reactant: 734593
reactant: 734581
notes: ERKP_bindsMKP_PP
fast: false
reversible: true
name: v58_w4
type: Reaction

124384
units: metaid_0000004
value: 12.8
name: k29
type: LocalParameter

735626
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

124316
units: metaid_0000005
value: 3.33
name: Km32_2a
type: LocalParameter

124258
units: metaid_0000004
value: 0.0
name: kt_2a
type: LocalParameter

metaid_0000160
notes: RGS4deact_GiaGTP
name: dissociation_RGS_Gqa_GTPcpx
kinetic law: 735541
product: 735529
reactant: 735493
product: 735505
type: Reaction
reversible: false
product: 735517
fast: false

734396
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

124344
units: metaid_0000004
value: 0.1
name: k24r_2a
type: LocalParameter

metaid_0000181
kinetic law: 736477
modifier: 736465
product: 736453
reactant: 736441
fast: false
reversible: false
name: AAfrom_PLA2star_Ca
type: Reaction

736441
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000122
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: cpxKetanserin_2ARGq
type: Species

metaid_0000056
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.61869
initial amount: NaN
in compartment: metaid_0000007
name: Gq_trimer
type: Species

metaid_0000102
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000007
name: Gitrimer
type: Species

124364
units: metaid_0000004
value: 4.0
name: k25_2a
type: LocalParameter

metaid_0000076
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.027257
initial amount: NaN
in compartment: metaid_0000007
name: RasGEF_star
type: Species

736682
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000140
kinetic law: 734569
product: 734556
reactant: 734543
notes: formERK_MKPPP
fast: false
reversible: false
name: w5
type: Reaction

735565
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

124278
units: metaid_0000004
value: 1.0
name: k13r_2a
type: LocalParameter

124259
units: metaid_0000006
value: 0.0
name: Vr_2a
type: LocalParameter

124317
units: metaid_0000004
value: 4.0
name: k41_2a
type: LocalParameter

124383
units: metaid_0000004
value: 51.2
name: k28r
type: LocalParameter

metaid_0000143
kinetic law: 734714
product: 734702
product: 734689
reactant: 734677
notes: releaseRaf_PP2A
fast: false
reversible: false
name: releaseRaf
type: Reaction

124450
units: metaid_0000004
value: 1.0E-4
name: k_ant_split
type: LocalParameter

124257
units: metaid_0000004
value: 0.17
name: k73
type: LocalParameter

738711
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

124313
units: metaid_0000005
value: 3.33
name: Km39_2a
type: LocalParameter

metaid_0000163
kinetic law: 735686
product: 735674
reactant: 735662
reactant: 735650
fast: false
reversible: false
name: Gqtrimerization
type: Reaction

metaid_0000121
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: cpxKetanserin_2AR
type: Species

metaid_0000057
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.4172E-4
initial amount: NaN
in compartment: metaid_0000007
name: Gq_a_GTP
type: Species

metaid_0000182
kinetic law: 736525
product: 736513
reactant: 736501
reactant: 736489
fast: false
reversible: true
name: AA_binds_PKC_Ca
type: Reaction

733732
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000077
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0015858
initial amount: NaN
in compartment: metaid_0000007
name: RasGAP_star
type: Species

metaid_0000101
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_HT1AR
type: Species

124314
units: metaid_0000004
value: 4.0
name: k39_2a
type: LocalParameter

738072
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

737370
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000142
kinetic law: 734665
product: 734653
product: 734641
reactant: 734629
notes: releaseERKPP_Rafstar
fast: false
reversible: false
name: releaseRafstarPP2A
type: Reaction

124256
units: metaid_0000004
value: 0.007
name: k2r_2a
type: LocalParameter

metaid_0000162
kinetic law: 735638
product: 735626
product: 735614
reactant: 735602
fast: false
reversible: false
name: Gqitrimer_GDP_to_Gbr_Gq_a_GTP
type: Reaction

124342
units: metaid_0000004
value: 5.99E-4
name: k22r_2a
type: LocalParameter

metaid_0000120
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: Ketanserin
type: Species

metaid_0000058
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0037173
initial amount: NaN
in compartment: metaid_0000007
name: Gq_betagamma
type: Species

734371
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000183
kinetic law: 736573
product: 736561
reactant: 736549
reactant: 736537
fast: false
reversible: true
name: AA_binds_PKC
type: Reaction

metaid_0000100
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.6929
initial amount: NaN
in compartment: metaid_0000007
name: HT1AR
type: Species

124362
units: metaid_0000004
value: 4.0
name: k31_2a
type: LocalParameter

metaid_0000078
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.39671
initial amount: NaN
in compartment: metaid_0000007
name: PIP2_PLA2
type: Species

737249
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

739460
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

124315
units: metaid_0000004
value: 4.0
name: k32_2a
type: LocalParameter

735224
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

737298
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000127
kinetic law: 733962
product: 733950
product: 733938
reactant: 733926
notes: releasePP2A_Rafstar
fast: false
reversible: false
name: releaseRafstarstar
type: Reaction

736767
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

124255
units: metaid_0000003
value: 1.0
name: k2_2a
type: LocalParameter

735493
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

739942
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

735602
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000165
kinetic law: 735782
product: 735770
reactant: 735758
reactant: 735746
notes: HT1ARbinds_Gitrimer
fast: false
reversible: true
name: Gqtrimer_GDP_with_5HT2AR
type: Reaction

739134
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

124380
units: metaid_0000003
value: 3.2
name: k28
type: LocalParameter

metaid_0000051
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.0192
initial amount: NaN
in compartment: metaid_0000007
name: ht2AR
type: Species

738264
stoichiometry: 1.0
species: metaid_0000093
type: SpeciesReference

metaid_0000079
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.3507E-7
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca_DAG
type: Species

738687
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

metaid_0000126
kinetic law: 733914
product: 733902
reactant: 733890
notes: releaseERKP_MKP_PP
fast: false
reversible: false
name: w2
type: Reaction

124369
units: metaid_0000004
value: 0.25
name: k23
type: LocalParameter

124312
units: metaid_0000004
value: 4.0
name: k40_2a
type: LocalParameter

734884
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

124254
units: metaid_0000004
value: 2.5
name: k1r_2a
type: LocalParameter

metaid_0000164
kinetic law: 735734
product: 735722
reactant: 735710
reactant: 735698
notes: cpxAR1Abinds_Gi
fast: false
reversible: true
name: HRbindsGqtrimer_GDP
type: Reaction

124368
units: metaid_0000004
value: 1.0
name: k22r
type: LocalParameter

metaid_0000052
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.010192
initial amount: NaN
in compartment: metaid_0000007
name: ht2AR_internal
type: Species

metaid_0000125
kinetic law: 733878
product: 733865
reactant: 733853
reactant: 733841
notes: v56_w1, h1, ERKPP_bindsMKPPP
fast: false
reversible: true
name: v56_w1
type: Reaction

metaid_0000167
kinetic law: 735878
product: 735866
reactant: 735854
reactant: 735842
notes: Abinds_RGi
fast: false
reversible: true
name: TCB_binds2ARGq
type: Reaction

739544
stoichiometry: 1.0
species: metaid_0000110
type: SpeciesReference

738735
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

124365
units: metaid_0000003
value: 35.0
name: k22
type: LocalParameter

metaid_0000053
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: A_2AR_i_deg
type: Species

738807
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

metaid_0000240
kinetic law: 739194
product: 739182
reactant: 739170
reactant: 739158
notes: Shcstarbinds_Grb2
fast: false
reversible: true
name: v38_Grb2_binds_Shcstar
type: Reaction

735080
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000054
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_2AR_internal
type: Species

metaid_0000124
kinetic law: 733829
product: 733817
product: 733805
reactant: 733792
notes: releaseERKP_MKPPP
fast: false
reversible: true
name: v57_w3
type: Reaction

737781
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000166
kinetic law: 735830
product: 735818
reactant: 735806
reactant: 735794
notes: HTbinds_HT1AR
fast: false
reversible: true
name: TCBbinds_2AR
type: Reaction

metaid_0000090
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.2
initial amount: NaN
in compartment: metaid_0000007
name: Src
type: Species

736159
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

739484
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

737480
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

735309
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

739206
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

737517
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000221
kinetic law: 738336
product: 738324
product: 738312
reactant: 738300
notes: deactSrc
fast: false
reversible: false
name: releaseSrc
type: Reaction

734835
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000080
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.3507E-6
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca_DAGactive
type: Species

739833
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

739906
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000202
kinetic law: 737455
modifier: 737443
product: 737431
product: 737419
reactant: 737407
fast: false
reversible: false
name: IP3DAG_byPIP2_PLCCaGq
type: Reaction

739170
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

metaid_0000168
kinetic law: 735914
product: 735902
reactant: 735890
notes: dep_PLA2star
fast: false
reversible: false
name: dep_PLA2_star
type: Reaction

736537
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

124433
units: metaid_0000005
value: 0.34
name: Km_33
type: LocalParameter

736023
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000148
kinetic law: 734959
product: 734947
product: 734934
reactant: 734922
notes: releaseERKP_MEKPP
fast: false
reversible: false
name: u2
type: Reaction

metaid_0000241
kinetic law: 739242
product: 739230
reactant: 739218
reactant: 739206
notes: Grb2binds_Sos
fast: false
reversible: true
name: v17_64_SosbindsGrb2
type: Reaction

metaid_0000222
kinetic law: 738384
product: 738372
reactant: 738360
reactant: 738348
notes: PTENbindsPIP3
fast: false
reversible: true
name: PIP3bindsPTEN
type: Reaction

736803
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

737009
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

124432
units: metaid_0000005
value: 8.0
name: km_bysrc
type: LocalParameter

metaid_0000169
kinetic law: 735938
product: 735926
fast: false
reversible: true
name: insertion
type: Reaction

metaid_0000201
kinetic law: 737395
modifier: 737382
product: 737370
product: 737358
reactant: 737346
fast: false
reversible: false
name: IP3DAG_byPIP2_PLCCa
type: Reaction

metaid_0000149
kinetic law: 735007
product: 734995
reactant: 734983
reactant: 734971
fast: false
reversible: true
name: PLA2starbinds_Ca
type: Reaction

734191
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000242
kinetic law: 739290
product: 739278
reactant: 739266
reactant: 739254
notes: Shcstarbinds_Grb2sos
fast: false
reversible: true
name: v41_83_Grb2_Sosbinds_Shc
type: Reaction

ORG:
  orgname: Weill Medical College of Cornell University
n:
  given: Chiung-wen Violet
  family: Chang

738445
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000223
kinetic law: 738433
product: 738420
product: 738408
reactant: 738396
notes: releasePIP2PTEN
fast: false
reversible: false
name: releasePTEN
type: Reaction

739592
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

734787
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

124431
units: metaid_0000004
value: 1.6
name: kcat_bysrc
type: LocalParameter

metaid_0000204
kinetic law: 737541
product: 737529
reactant: 737517
fast: false
reversible: true
name: releasePKc_Ca_DAGactive
type: Reaction

734629
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000082
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 83332.0
initial amount: NaN
in compartment: metaid_0000007
name: PA
type: Species

734581
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

736096
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

737407
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

124419
units: metaid_0000004
value: 0.0214
name: k35r
type: LocalParameter

738783
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000243
kinetic law: 739338
product: 739326
reactant: 739314
reactant: 739302
notes: ShcstarGrb2_binds_Sos
fast: false
reversible: true
name: v40_Sosbinds_ShcstarGrb2
type: Reaction

735285
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

738408
stoichiometry: 1.0
species: metaid_0000095
type: SpeciesReference

metaid_0000224
kinetic law: 738469
product: 738457
reactant: 738445
notes: degPI3Kstar
fast: false
reversible: false
name: deactPI3K_star
type: Reaction

735430
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000203
kinetic law: 737504
product: 737492
reactant: 737480
reactant: 737468
fast: false
reversible: true
name: DAGbindsPKC
type: Reaction

735406
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

124430
units: metaid_0000004
value: 1.0
name: kdd
type: LocalParameter

metaid_0000081
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.31811
initial amount: NaN
in compartment: metaid_0000007
name: PKC_DAG_AAactive
type: Species

733768
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

737274
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

736211
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

737553
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

739436
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000244
kinetic law: 739388
product: 739376
product: 739363
reactant: 739351
notes: releaseShcstar_Grb2sos
fast: false
reversible: true
name: v33_splitShc_star_Grb2_Sos
type: Reaction

metaid_0000084
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.8983
initial amount: NaN
in compartment: metaid_0000007
name: PIP
type: Species

metaid_0000206
kinetic law: 737625
product: 737613
reactant: 737601
fast: false
reversible: true
name: PKC_DAG_AAactive
type: Reaction

124349
units: metaid_0000004
value: 0.0133
name: k15_2a
type: LocalParameter

metaid_0000019
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.094895
initial amount: NaN
in compartment: metaid_0000007
name: cpxERK_MEK_PP
type: Species

736645
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

124417
units: metaid_0000004
value: 0.1
name: k36r
type: LocalParameter

metaid_0000245
kinetic law: 739424
product: 739412
reactant: 739400
notes: dep_Grb2SosP
fast: false
reversible: false
name: dep_Sos_P
type: Reaction

735662
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

124438
units: metaid_0000004
value: 0.08
name: k42r
type: LocalParameter

metaid_0000144
kinetic law: 734762
product: 734750
reactant: 734738
reactant: 734726
notes: PP2Abinds_Rafstar
fast: false
reversible: true
name: Rafstarbinds_PP2A
type: Reaction

735986
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

737916
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000083
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 94.922
initial amount: NaN
in compartment: metaid_0000007
name: PI
type: Species

metaid_0000205
kinetic law: 737589
product: 737577
reactant: 737565
reactant: 737553
fast: false
reversible: true
name: AAbinds_PKC_DAG
type: Reaction

124348
units: metaid_0000004
value: 0.2
name: k60r_2a
type: LocalParameter

734506
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

733853
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000059
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0027739
initial amount: NaN
in compartment: metaid_0000007
name: Gq_a_GDP
type: Species

124418
units: metaid_0000003
value: 10.0
name: k35
type: LocalParameter

metaid_0000246
kinetic law: 739472
product: 739460
product: 739448
reactant: 739436
notes: releaseGrb2_Sos
fast: false
reversible: true
name: v35_splitGrb2_Sos
type: Reaction

124437
units: metaid_0000003
value: 0.2
name: k42
type: LocalParameter

metaid_0000145
kinetic law: 734811
product: 734799
reactant: 734787
reactant: 734774
fast: false
reversible: true
name: Rafstar_bindsERKPP
type: Reaction

metaid_0000086
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_br_PI3K
type: Species

734275
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

124347
units: metaid_0000004
value: 2.0
name: k60_2a
type: LocalParameter

736827
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000208
kinetic law: 737721
product: 737709
reactant: 737697
fast: false
reversible: false
name: degradeAA
type: Reaction

737988
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

124346
units: metaid_0000004
value: 2.0
name: k59r_2a
type: LocalParameter

735321
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000247
name: Sos_PbyERK_PP
kinetic law: 739532
type: Reaction
notes: Grb2sosP_byERKPP
reactant: 739484
modifier: 739520
product: 739508
product: 739496
fast: false
reversible: false

124415
units: metaid_0000004
value: 0.0667
name: k8
type: LocalParameter

metaid_0000146
kinetic law: 734860
product: 734847
product: 734835
reactant: 734823
notes: releaseMEKPP_ERKPP
fast: false
reversible: false
name: v55_u4
type: Reaction

124436
units: metaid_0000006
value: 0.17
name: Vm_33
type: LocalParameter

734605
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000085
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.16
initial amount: NaN
in compartment: metaid_0000007
name: PI3K
type: Species

737661
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

739326
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

737577
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000207
kinetic law: 737685
product: 737673
product: 737661
product: 737649
reactant: 737637
fast: false
reversible: false
name: inact_PLCb_Ca_Gq_a_GTP
type: Reaction

739412
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000220
kinetic law: 738288
product: 738276
reactant: 738264
reactant: 738252
fast: false
reversible: true
name: Srcstar_bindsCsk
type: Reaction

metaid_0000248
kinetic law: 739580
modifier: 739568
product: 739556
reactant: 739544
fast: false
reversible: false
name: ShcactbySrcstar
type: Reaction

124345
units: metaid_0000003
value: 0.018
name: k59_2a
type: LocalParameter

124416
units: metaid_0000003
value: 3.0
name: k36
type: LocalParameter

738108
stoichiometry: 1.0
species: metaid_0000088
type: SpeciesReference

metaid_0000147
kinetic law: 734910
product: 734897
reactant: 734884
reactant: 734872
notes: u1
fast: false
reversible: true
name: u1
type: Reaction

738493
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

733817
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000249
kinetic law: 739628
product: 739616
product: 739604
reactant: 739592
notes: degShcstar
fast: false
reversible: false
name: v36_depShc_star
type: Reaction

metaid_0000035
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.15859
initial amount: NaN
in compartment: metaid_0000007
name: PP2A
type: Species

metaid_0000088
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: PIP2_PI3Kstar
type: Species

734034
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

124413
units: metaid_0000004
value: 33.32
name: k9r
type: LocalParameter

738216
stoichiometry: 1.0
species: metaid_0000092
type: SpeciesReference

124296
units: metaid_0000004
value: 36.0
name: k83_2a
type: LocalParameter

734335
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000229
kinetic law: 738627
product: 738615
fast: false
reversible: true
name: insertion_1a
type: Reaction

metaid_0000015
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 2.2131E-5
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKPP_Rafstar
type: Species

metaid_0000087
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: PI3Kstar
type: Species

735770
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

739701
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

739508
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000036
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.048958
initial amount: NaN
in compartment: metaid_0000007
name: MEK_P
type: Species

124414
units: metaid_0000004
value: 8.33
name: k10
type: LocalParameter

736108
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

739653
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

124219
units: metaid_0000003
value: 6.0
name: k83
type: LocalParameter

124297
units: metaid_0000004
value: 5.4
name: k64_2a
type: LocalParameter

124239
units: metaid_0000004
value: 8.33
name: k10_2a
type: LocalParameter

738312
stoichiometry: 1.0
species: metaid_0000090
type: SpeciesReference

metaid_0000016
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 5.8373E-4
initial amount: NaN
in compartment: metaid_0000007
name: cpxRafstar_PP2A
type: Species

metaid_0000037
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.028395
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEK_Rafstar
type: Species

735710
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

735806
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

739278
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

124410
units: metaid_0000003
value: 20.83
name: k9
type: LocalParameter

124238
units: metaid_0000004
value: 1.2E-4
name: k44r
type: LocalParameter

739302
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

124298
units: metaid_0000005
value: 20.0
name: Km64_2a
type: LocalParameter

metaid_0000017
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0090591
initial amount: NaN
in compartment: metaid_0000007
name: ERK_PP
type: Species

736597
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

738024
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

734359
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000038
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.078866
initial amount: NaN
in compartment: metaid_0000007
name: MEK
type: Species

124439
units: metaid_0000004
value: 0.02
name: k43
type: LocalParameter

737964
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

738420
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000089
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: PIP3
type: Species

124236
units: metaid_0000004
value: 0.5
name: k45r
type: LocalParameter

734653
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

124217
units: metaid_0000004
value: 0.01
name: k60
type: LocalParameter

736271
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

124299
units: metaid_0000004
value: 0.14
name: k19_2a
type: LocalParameter

124237
units: metaid_0000004
value: 1.6E-4
name: k44
type: LocalParameter

metaid_0000018
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.2945E-5
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKP_MEKPP
type: Species

737346
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

736319
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

124216
units: metaid_0000004
value: 1.0
name: k59r
type: LocalParameter

124192
units: metaid_0000004
value: 0.42
name: k49r
type: LocalParameter

734311
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000039
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.057628
initial amount: NaN
in compartment: metaid_0000007
name: Rafstar
type: Species

metaid_0000011
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0018979
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKP_MKP_PPstar
type: Species

733890
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000225
kinetic law: 738506
product: 738493
reactant: 738481
fast: false
reversible: false
name: LRinternal_1a
type: Reaction

124215
units: metaid_0000003
value: 20.0
name: k59
type: LocalParameter

737601
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000012
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0021849
initial amount: NaN
in compartment: metaid_0000007
name: Rafstarstar
type: Species

736973
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

735455
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

735794
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

735517
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

735854
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

733986
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

736513
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

736047
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

124214
units: metaid_0000004
value: 15.0
name: k62
type: LocalParameter

metaid_0000226
kinetic law: 738542
product: 738530
reactant: 738518
fast: false
reversible: false
name: LR_internal_deg
type: Reaction

739254
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

735176
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

737769
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

124194
units: metaid_0000003
value: 1.92
name: k57
type: LocalParameter

734142
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

124294
units: metaid_0000004
value: 0.012
name: k65r_2a
type: LocalParameter

metaid_0000200
kinetic law: 737334
modifier: 737322
product: 737310
reactant: 737298
fast: false
reversible: false
name: AAfrom_PIP2PLA2
type: Reaction

734738
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000227
kinetic law: 738579
product: 738566
reactant: 738554
fast: false
reversible: true
name: receptor_interl
type: Reaction

739230
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000013
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 3.0847E-4
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEKPP_PP2A
type: Species

124213
units: metaid_0000004
value: 40.0
name: k75r
type: LocalParameter

736295
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

735116
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

124193
units: metaid_0000004
value: 6.0
name: k58
type: LocalParameter

737057
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

735261
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000014
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 2.2131E-5
initial amount: NaN
in compartment: metaid_0000007
name: cpxRafstarstar_PP2A
type: Species

738360
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

metaid_0000228
kinetic law: 738603
reactant: 738591
fast: false
reversible: false
name: ligand1a_deg
type: Reaction

124212
units: metaid_0000003
value: 1.95
name: k75
type: LocalParameter

739616
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

734677
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

124295
units: metaid_0000005
value: 20.0
name: Km83_2a
type: LocalParameter

735370
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

738891
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

124291
units: metaid_0000003
value: 0.1
name: k65_2a
type: LocalParameter

W3 CDTF: Fri Nov 28 11:16:16 GMT 2008

124378
units: metaid_0000004
value: 14.0
name: k31
type: LocalParameter

metaid_0000178
kinetic law: 736331
product: 736319
reactant: 736307
reactant: 736295
fast: false
reversible: true
name: PLCb_Ca_binds_Gq_a_GTP
type: Reaction

735842
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

733780
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

738348
stoichiometry: 1.0
species: metaid_0000095
type: SpeciesReference

metaid_0000198
kinetic law: 737237
modifier: 737225
product: 737213
reactant: 737201
fast: false
reversible: false
name: PKC_DAG_AAregu_RasGEF
type: Reaction

737105
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

733696
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

124306
units: metaid_0000005
value: 3.33
name: Km38_2a
type: LocalParameter

metaid_0000117
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Shcstar_Grb2_Sos
type: Species

124398
units: metaid_0000003
value: 0.0599
name: k3
type: LocalParameter

124290
units: metaid_0000004
value: 0.1
name: k61r_2a
type: LocalParameter

124377
units: metaid_0000004
value: 56.0
name: k30r
type: LocalParameter

734922
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

738831
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

739809
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

metaid_0000179
kinetic law: 736380
product: 736368
reactant: 736356
reactant: 736344
fast: false
reversible: true
name: PKC_binds_Ca
type: Reaction

738747
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

738168
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

metaid_0000199
kinetic law: 737286
product: 737274
reactant: 737261
reactant: 737249
fast: false
reversible: true
name: PIP2_binds_PLA2
type: Reaction

metaid_0000116
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Grb2_sos
type: Species

124397
units: metaid_0000004
value: 0.1
name: k1r
type: LocalParameter

124307
units: metaid_0000004
value: 1.0
name: k36_2a
type: LocalParameter

734408
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

124174
units: metaid_0000003
value: 10.0
name: k67r
type: LocalParameter

W3 CDTF: Wed Oct 07 15:45:53 BST 2009

metaid_0000196
kinetic law: 737141
modifier: 737129
product: 737117
reactant: 737105
fast: false
reversible: false
name: PKC_AAactRasGEF
type: Reaction

metaid_0000176
kinetic law: 736235
product: 736223
reactant: 736211
reactant: 736199
fast: false
reversible: true
name: PLCb_binds_Ca
type: Reaction

734445
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

124171
units: metaid_0000004
value: 1.0
name: k67
type: LocalParameter

736888
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

metaid_0000119
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Grb2_sos_P
type: Species

738252
stoichiometry: 1.0
species: metaid_0000092
type: SpeciesReference

738699
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

metaid_0000177
kinetic law: 736283
product: 736271
reactant: 736259
reactant: 736247
fast: false
reversible: true
name: PLCb_Gq_a_GTPbinds_Ca
type: Reaction

739785
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000197
kinetic law: 737189
modifier: 737177
product: 737165
reactant: 737153
fast: false
reversible: false
name: PKC_Ca_AAactRasGEF
type: Reaction

739930
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

734178
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

124309
units: metaid_0000005
value: 3.33
name: Km40_2a
type: LocalParameter

735746
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

metaid_0000118
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxRasGDP_Shcstar_Grb2_Sos
type: Species

737213
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

734983
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

124261
units: metaid_0000004
value: 0.005
name: v6_2a
type: LocalParameter

124374
units: metaid_0000004
value: 4.52
name: k26r
type: LocalParameter

734897
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

734227
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000022
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.48458
initial amount: NaN
in compartment: metaid_0000007
name: MKP
type: Species

739689
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

124177
units: metaid_0000004
value: 0.092
name: k66
type: LocalParameter

735031
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

739074
stoichiometry: 1.0
species: metaid_0000109
type: SpeciesReference

metaid_0000174
kinetic law: 736133
product: 736120
product: 736108
product: 736096
reactant: 736084
fast: false
reversible: false
name: cpxARGq_split
type: Reaction

metaid_0000061
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.4492E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLCb_Gq_a_GTP
type: Species

737637
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000175
kinetic law: 736185
product: 736172
reactant: 736159
reactant: 736146
fast: false
reversible: true
name: PLCb_binds_Gq_a_GTP
type: Reaction

124260
units: metaid_0000004
value: 2.43E-5
name: kh_2a
type: LocalParameter

738084
stoichiometry: 1.0
species: metaid_0000088
type: SpeciesReference

124373
units: metaid_0000003
value: 1.6143
name: k26
type: LocalParameter

734947
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

734556
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000021
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.066479
initial amount: NaN
in compartment: metaid_0000007
name: cpxERK_MKP_PP
type: Species

124178
units: metaid_0000004
value: 6.0
name: k54
type: LocalParameter

739363
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

738855
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

124221
units: metaid_0000004
value: 0.1
name: k83r
type: LocalParameter

734022
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000062
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0093825
initial amount: NaN
in compartment: metaid_0000007
name: PLCb_Ca
type: Species

738204
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

737153
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

739749
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

738940
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

734469
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

738966
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

734094
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

124376
units: metaid_0000003
value: 2.33
name: k30
type: LocalParameter

metaid_0000020
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.030392
initial amount: NaN
in compartment: metaid_0000007
name: MEK_PP
type: Species

124263
units: metaid_0000004
value: 6.67E-4
name: v62_2a
type: LocalParameter

124175
units: metaid_0000003
value: 45.0
name: k65
type: LocalParameter

734641
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

124222
units: metaid_0000003
value: 3.2
name: k61
type: LocalParameter

metaid_0000172
kinetic law: 736035
product: 736023
reactant: 736010
fast: false
reversible: false
name: L2sR_internal_deg
type: Reaction

735722
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

737733
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

124375
units: metaid_0000004
value: 1.13
name: k27
type: LocalParameter

124262
units: metaid_0000004
value: 5.0E-5
name: v6r_2a
type: LocalParameter

124176
units: metaid_0000004
value: 1.0
name: k65r
type: LocalParameter

metaid_0000173
kinetic law: 736072
product: 736059
reactant: 736047
fast: false
reversible: false
name: L2aRinternal
type: Reaction

739014
stoichiometry: 1.0
species: metaid_0000109
type: SpeciesReference

124223
units: metaid_0000004
value: 1.0
name: k61r
type: LocalParameter

metaid_0000060
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.090022
initial amount: NaN
in compartment: metaid_0000007
name: PLCb
type: Species

metaid_0000045
constant: false
boundary condition: true
has only substance units: false
substance units: mole
initial concentration: 2.6578
initial amount: NaN
in compartment: metaid_0000007
name: PIP2
type: Species

734420
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000170
kinetic law: 735962
reactant: 735950
fast: false
reversible: false
name: ligand_deg
type: Reaction

124390
units: metaid_0000004
value: 5.0E-5
name: v6r
type: LocalParameter

738879
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

metaid_0000131
kinetic law: 734154
product: 734142
product: 734130
reactant: 734118
notes: basalGi_a_GTPsplit
fast: false
reversible: false
name: basal_Gq_a_GTP_split_rx
type: Reaction

738120
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

124245
units: metaid_0000003
value: 1.0
name: k4_2a
type: LocalParameter

metaid_0000151
kinetic law: 735104
product: 735092
reactant: 735080
reactant: 735068
notes: PLA2binds_Ca
fast: false
reversible: true
name: PLA2_binds_Ca
type: Reaction

734118
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

738060
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000190
kinetic law: 736863
modifier: 736851
product: 736839
reactant: 736827
fast: false
reversible: false
name: PKC_Ca_DAGactive_actRasGAP
type: Reaction

metaid_0000065
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.055555
initial amount: NaN
in compartment: metaid_0000007
name: DAG
type: Species

733744
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

124370
units: metaid_0000003
value: 0.7813
name: k24
type: LocalParameter

124330
units: metaid_0000004
value: 0.0012
name: k80r_2a
type: LocalParameter

metaid_0000046
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 618.69
initial amount: NaN
in compartment: metaid_0000007
name: Pi
type: Species

739218
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

737529
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000171
kinetic law: 735998
product: 735986
reactant: 735974
fast: false
reversible: true
name: receptor2a_inter
type: Reaction

735974
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000150
kinetic law: 735056
product: 735043
reactant: 735031
reactant: 735019
notes: ERKPbinds_MEKPP
fast: false
reversible: true
name: v54_u3
type: Reaction

747723
kinetic law: 739821
product: 739809
reactant: 739797
reactant: 739785
fast: false
reversible: true
name: Ketanserinbinds_2AR
type: Reaction

124264
units: metaid_0000004
value: 0.00235
name: ke_2a
type: LocalParameter

metaid_0000130
kinetic law: 734106
product: 734094
reactant: 734082
reactant: 734070
notes: PLA2binds_ERKPP
fast: false
reversible: true
name: ERKPPbinds_PLA2
type: Reaction

metaid_0000066
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.062951
initial amount: NaN
in compartment: metaid_0000007
name: PKC
type: Species

metaid_0000191
kinetic law: 736900
product: 736888
reactant: 736876
fast: false
reversible: false
name: GEF_deact
type: Reaction

124350
units: metaid_0000004
value: 0.4
name: k79_2a
type: LocalParameter

735212
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000063
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.5038E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLCb_Ca_Gq_a_GTP
type: Species

734750
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

739122
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

738651
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

124392
units: metaid_0000006
value: 0.0
name: Vr
type: LocalParameter

metaid_0000043
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 4.1421E-4
initial amount: NaN
in compartment: metaid_0000007
name: RasGAP
type: Species

124331
units: metaid_0000004
value: 11.04
name: k84_2a
type: LocalParameter

metaid_0000111
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: serotonin
type: Species

124440
units: metaid_0000004
value: 0.02
name: k37_2a
type: LocalParameter

736344
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

124267
units: metaid_0000003
value: 2.52
name: k11_2a
type: LocalParameter

124372
units: metaid_0000004
value: 0.625
name: k25
type: LocalParameter

739400
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

124248
units: metaid_0000004
value: 0.004667
name: k4r_2a
type: LocalParameter

735614
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

124328
units: metaid_0000005
value: 3.33
name: Km35_2a
type: LocalParameter

733708
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000209
kinetic law: 737757
product: 737745
reactant: 737733
fast: false
reversible: false
name: PIgene
type: Reaction

124351
units: metaid_0000004
value: 1.0
name: k_PA
type: LocalParameter

739858
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

736755
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

124199
units: metaid_0000003
value: 31.5625
name: k63
type: LocalParameter

metaid_0000064
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.21952
initial amount: NaN
in compartment: metaid_0000007
name: IP3
type: Species

124391
units: metaid_0000004
value: 2.43E-5
name: kh
type: LocalParameter

metaid_0000044
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.076348
initial amount: NaN
in compartment: metaid_0000007
name: RasGDP
type: Species

metaid_0000110
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.45
initial amount: NaN
in compartment: metaid_0000007
name: Shc
type: Species

734070
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

124441
units: metaid_0000005
value: 0.50505
name: km37_2a
type: LocalParameter

738566
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

124266
units: metaid_0000004
value: 0.04
name: k5_2a
type: LocalParameter

747725
kinetic law: 739870
product: 739858
reactant: 739845
reactant: 739833
fast: false
reversible: true
name: Ket_2ARGq_split
type: Reaction

124329
units: metaid_0000003
value: 0.5
name: k80_2a
type: LocalParameter

124371
units: metaid_0000004
value: 2.5
name: k24r
type: LocalParameter

736730
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

747729
kinetic law: 739966
product: 739954
product: 739942
reactant: 739930
fast: false
reversible: false
name: Ketanserin2ARGq_split
type: Reaction

124394
units: metaid_0000003
value: 100.0
name: k2
type: LocalParameter

124241
units: metaid_0000004
value: 33.32
name: k9r_2a
type: LocalParameter

124321
units: metaid_0000005
value: 3.33
name: Km43_2a
type: LocalParameter

metaid_0000252
kinetic law: 739773
modifier: 739761
product: 739749
reactant: 739737
fast: false
reversible: false
name: RasGDPbyRasGEFstar
type: Reaction

metaid_0000113
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.12
initial amount: NaN
in compartment: metaid_0000007
name: Sos
type: Species

733720
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

736146
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

735019
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

124353
units: metaid_0000004
value: 4.0
name: k29_2a
type: LocalParameter

metaid_0000041
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.030124
initial amount: NaN
in compartment: metaid_0000007
name: Raf
type: Species

metaid_0000194
kinetic law: 737045
modifier: 737033
product: 737021
reactant: 737009
fast: false
reversible: false
name: PKC_DAG_AAactive_actRasGAP
type: Reaction

metaid_0000069
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.031811
initial amount: NaN
in compartment: metaid_0000007
name: PKC_DAG_AA
type: Species

736609
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

metaid_0000155
kinetic law: 735297
product: 735285
product: 735273
reactant: 735261
notes: releaseMEKP_Rafstar
fast: false
reversible: false
name: v45_87
type: Reaction

737431
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

124269
units: metaid_0000003
value: 3.0
name: k12_2a
type: LocalParameter

736259
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

739556
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

124240
units: metaid_0000003
value: 20.83
name: k9_2a
type: LocalParameter

124303
units: metaid_0000004
value: 0.15
name: k20_2a
type: LocalParameter

737868
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

124322
units: metaid_0000004
value: 4.0
name: k43_2a
type: LocalParameter

735092
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000112
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.255
initial amount: NaN
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name: Grb2
type: Species

124393
units: metaid_0000004
value: 0.0
name: kt
type: LocalParameter

124197
units: metaid_0000004
value: 5.0
name: k64
type: LocalParameter

737492
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

metaid_0000195
kinetic law: 737093
modifier: 737081
product: 737069
reactant: 737057
fast: false
reversible: false
name: PKC_Ca_DAGactive_actRasGEF
type: Reaction

metaid_0000251
kinetic law: 739725
product: 739713
product: 739701
reactant: 739689
notes: RasGTP_byShcstarGrb2Sos
fast: false
reversible: false
name: releaseRasGTPfromShc
type: Reaction

735950
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000042
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.02024
initial amount: NaN
in compartment: metaid_0000007
name: RasGTP
type: Species

metaid_0000154
kinetic law: 735249
product: 735236
reactant: 735224
reactant: 735212
notes: PP2Abinds_MEKP
fast: false
reversible: true
name: v50_92
type: Reaction

124302
units: metaid_0000005
value: 0.16
name: IP3basal
type: LocalParameter

747727
kinetic law: 739918
product: 739906
reactant: 739894
reactant: 739882
fast: false
reversible: true
name: cpxKetR_bindsGq
type: Reaction

124268
units: metaid_0000004
value: 1.0
name: k11r_2a
type: LocalParameter

739496
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

124323
units: metaid_0000005
value: 3.33
name: Km42_2a
type: LocalParameter

124304
units: metaid_0000004
value: 0.1
name: k33_2a
type: LocalParameter

124243
units: metaid_0000003
value: 6.0
name: k6_2a
type: LocalParameter

124396
units: metaid_0000003
value: 0.45
name: k1
type: LocalParameter

736120
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

739954
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000115
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Shcstar_Grb2
type: Species

124196
units: metaid_0000004
value: 1.0
name: k82
type: LocalParameter

736416
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

736368
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

734493
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000250
kinetic law: 739677
product: 739665
reactant: 739653
reactant: 739640
notes: RasGDPbinds_Shrcstar_Grb2_Sos
fast: false
reversible: true
name: RasGDPbinds_ShcstarGrb2Sos
type: Reaction

metaid_0000067
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0026242
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca
type: Species

738518
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

metaid_0000192
kinetic law: 736948
modifier: 736936
product: 736924
reactant: 736912
fast: false
reversible: false
name: PKC_AA_actRasGAP
type: Reaction

738276
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

metaid_0000153
kinetic law: 735200
product: 735188
product: 735176
reactant: 735164
notes: releaseMEK_PP2A
fast: false
reversible: false
name: v51_93
type: Reaction

734774
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

124324
units: metaid_0000004
value: 4.0
name: k42_2a
type: LocalParameter

metaid_0000152
kinetic law: 735152
product: 735140
product: 735128
reactant: 735116
notes: releaseRafstar_RasGTP
fast: false
reversible: false
name: releaseRafstardRasGTP
type: Reaction

124305
units: metaid_0000004
value: 4.0
name: k38_2a
type: LocalParameter

124242
units: metaid_0000004
value: 1.0E-4
name: k7_2a
type: LocalParameter

124395
units: metaid_0000004
value: 0.1
name: k2r
type: LocalParameter

124195
units: metaid_0000004
value: 24.0
name: k57r
type: LocalParameter

734872
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000114
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Shc_star
type: Species

739894
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

735553
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

124356
units: metaid_0000005
value: 66.67
name: Km29_2a
type: LocalParameter

metaid_0000040
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.023412
initial amount: NaN
in compartment: metaid_0000007
name: cpxRasGTP_Raf
type: Species

metaid_0000193
kinetic law: 736997
modifier: 736985
product: 736973
reactant: 736960
fast: false
reversible: false
name: PKC_Ca_AAactRasGAP
type: Reaction

736453
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000068
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.58385
initial amount: NaN
in compartment: metaid_0000007
name: PKC_DAG
type: Species

124325
units: metaid_0000004
value: 4.0
name: k35_2a
type: LocalParameter

736084
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000158
kinetic law: 735442
product: 735430
reactant: 735418
reactant: 735406
notes: Rafbinds_RasGTP
fast: false
reversible: true
name: RasGTPbinds_Raf
type: Reaction

metaid_0000094
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxCsk_Srcstar
type: Species

737261
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000235
kinetic law: 738915
product: 738903
product: 738891
reactant: 738879
fast: false
reversible: false
name: Gitrimer_GDP_to_Gbr,Gi_a_GTP
type: Reaction

734799
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000216
kinetic law: 738096
product: 738084
reactant: 738072
reactant: 738060
notes: PIP2binds_PI3Kstar
fast: false
reversible: true
name: PIP2bindfsPI3Kstar
type: Reaction

124339
units: metaid_0000003
value: 0.1
name: k22_2a
type: LocalParameter

124407
units: metaid_0000004
value: 1.0E-4
name: k7
type: LocalParameter

737069
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

738795
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

124359
units: metaid_0000005
value: 66.67
name: Km31_2a
type: LocalParameter

735273
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000138
kinetic law: 734481
product: 734469
reactant: 734457
reactant: 734445
notes: MKPbinds_ERKPP
fast: false
reversible: true
name: ERK_PPbinds_MKP
type: Reaction

734593
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

734263
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000159
kinetic law: 735481
product: 735468
reactant: 735455
fast: false
reversible: true
name: intrinsicRas
type: Reaction

metaid_0000215
kinetic law: 738048
product: 738036
product: 738024
reactant: 738012
notes: releasePI3Kstar_betagamma
fast: false
reversible: false
name: release_activePI3K
type: Reaction

metaid_0000093
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.3
initial amount: NaN
in compartment: metaid_0000007
name: Csk
type: Species

733756
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

736010
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

124357
units: metaid_0000005
value: 66.67
name: Km30_2a
type: LocalParameter

metaid_0000236
reversible: false
reactant: 738927
kinetic law: 738990
product: 738940
fast: false
product: 738953
notes: cpxARGi_split
product: 738966
type: Reaction
product: 738978
name: H1ARGi_split

734726
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

124338
units: metaid_0000004
value: 48.0
name: k17_2a
type: LocalParameter

124358
units: metaid_0000004
value: 4.0
name: k30_2a
type: LocalParameter

metaid_0000139
kinetic law: 734530
product: 734518
product: 734506
reactant: 734493
notes: releaseERK_MKPPP
fast: false
reversible: true
name: v59_w6
type: Reaction

739448
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

736223
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

739845
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000092
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Src_star
type: Species

metaid_0000156
kinetic law: 735346
product: 735334
reactant: 735321
reactant: 735309
notes: MEKbinds_Rafstar
fast: false
reversible: true
name: v44_86
type: Reaction

124421
units: metaid_0000004
value: 0.0429
name: k34r
type: LocalParameter

739182
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

733950
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000214
kinetic law: 738000
product: 737988
reactant: 737976
reactant: 737964
notes: Gi_brbinds_PI3K
fast: false
reversible: true
name: bindingofPI3K_Gibr
type: Reaction

metaid_0000233
kinetic law: 738819
product: 738807
reactant: 738795
reactant: 738783
notes: cpxAR1Abinds_Gi
fast: false
reversible: true
name: HRbindsGitrimer_GDP
type: Reaction

734823
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

MODEL0975191032
is described by: http://identifiers.org/pubmed/18762202
species: metaid_0000025
species: metaid_0000061
reaction: metaid_0000148
reaction: metaid_0000171
reaction: metaid_0000246
reaction: metaid_0000203
units def: metaid_0000004
reaction: metaid_0000221
species: metaid_0000036
type: SBMLModel
species: metaid_0000072
reaction: metaid_0000198
reaction: metaid_0000133
area units: area
reaction: metaid_0000183
reaction: metaid_0000140
reaction: metaid_0000192
reaction: metaid_0000215
species: metaid_0000022
reaction: metaid_0000127
reaction: metaid_0000131
species: metaid_0000119
reaction: metaid_0000233
reaction: metaid_0000145
reaction: metaid_0000200
reaction: metaid_0000250
species: metaid_0000039
species: metaid_0000010
curated: false
reaction: metaid_0000143
reaction: metaid_0000172
reaction: metaid_0000247
reaction: metaid_0000238
species: metaid_0000086
species: metaid_0000053
reaction: metaid_0000124
reaction: metaid_0000159
species: metaid_0000027
species: metaid_0000055
species: metaid_0000035
species: metaid_0000071
reaction: metaid_0000134
species: metaid_0000064
reaction: metaid_0000184
species: metaid_0000041
species: metaid_0000082
species: metaid_0000120
reaction: metaid_0000175
reaction: metaid_0000151
species: metaid_0000043
species: metaid_0000023
reaction: metaid_0000227
species: metaid_0000052
reaction: 747727
reaction: metaid_0000139
species: metaid_0000089
reaction: metaid_0000244
reaction: metaid_0000251
reaction: metaid_0000187
reaction: metaid_0000163
reaction: metaid_0000239
reaction: metaid_0000181
reaction: metaid_0000168
species: metaid_0000026
species: metaid_0000008
species: metaid_0000062
species: metaid_0000116
reaction: metaid_0000206
units def: metaid_0000003
reaction: metaid_0000241
reaction: metaid_0000224
species: metaid_0000069
reaction: metaid_0000195
reaction: metaid_0000176
reaction: metaid_0000160
species: metaid_0000014
species: metaid_0000077
species: metaid_0000050
reaction: metaid_0000152

124409
units: metaid_0000004
value: 0.025
name: k5
type: LocalParameter

124320
units: metaid_0000005
value: 3.33
name: Km41_2a
type: LocalParameter

metaid_0000136
kinetic law: 734383
product: 734371
reactant: 734359
notes: degMKP_PP
fast: false
reversible: false
name: MKP_PPdegrade
type: Reaction

124449
units: metaid_0000004
value: 1.67
name: krant_KRbindsG
type: LocalParameter

735358
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000091
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxSrc_PIP3
type: Species

metaid_0000213
kinetic law: 737952
modifier: 737940
product: 737928
reactant: 737916
fast: false
reversible: false
name: RafactbyPKC_DAG_AAactive
type: Reaction

metaid_0000157
kinetic law: 735394
modifier: 735382
product: 735370
reactant: 735358
notes: releaseRasGDPRasGAP
fast: false
reversible: false
name: RasGTPactbyGAP
type: Reaction

124420
units: metaid_0000003
value: 9.0
name: k34
type: LocalParameter

733865
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000234
kinetic law: 738867
product: 738855
reactant: 738843
reactant: 738831
fast: false
reversible: false
name: Gitrimerization
type: Reaction

737928
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

738591
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

metaid_0000137
kinetic law: 734433
product: 734420
product: 734408
reactant: 734396
fast: false
reversible: false
name: releaseERKPP_MKPPP
type: Reaction

metaid_0000009
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.010263
initial amount: NaN
in compartment: metaid_0000007
name: cpxERK_PP_MKP_PP
type: Species

738396
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

metaid_0000231
kinetic law: 738723
product: 738711
reactant: 738699
reactant: 738687
notes: HTbinds_HT1AR
fast: false
reversible: true
name: HTbinds_1AR
type: Reaction

736694
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

737468
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

124423
units: metaid_0000004
value: 0.064
name: k37r
type: LocalParameter

734287
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

124249
units: metaid_0000003
value: 1.0
name: k3_2a
type: LocalParameter

124443
units: metaid_0000004
value: 2.5
name: k1r_ant
type: LocalParameter

738927
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

124424
units: metaid_0000004
value: 2.0
name: k39
type: LocalParameter

metaid_0000098
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: A_HT1R_i_deg
type: Species

metaid_0000134
kinetic law: 734299
product: 734287
product: 734275
reactant: 734263
notes: releasePP2A_MEKP
fast: false
reversible: false
name: v49_91
type: Reaction

124334
units: metaid_0000005
value: 20.0
name: Km84_2a
type: LocalParameter

124403
units: metaid_0000004
value: 0.1
name: k3r
type: LocalParameter

737565
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

736247
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000232
kinetic law: 738771
product: 738759
reactant: 738747
reactant: 738735
notes: HT1ARbinds_Gitrimer
fast: false
reversible: true
name: Gitrimer_GDP_with_5HT1AR
type: Reaction

metaid_0000219
kinetic law: 738240
product: 738228
product: 738216
reactant: 738204
notes: releaseSrcstar_PIP3
fast: false
reversible: false
name: releaseSrcstar
type: Reaction

734847
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

124422
units: metaid_0000003
value: 30.0
name: k37
type: LocalParameter

metaid_0000097
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_HT1AR_internal
type: Species

735578
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

738481
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000135
kinetic law: 734347
product: 734335
reactant: 734323
reactant: 734311
notes: MEKPPbinds_PP2A
fast: false
reversible: true
name: v48_90
type: Reaction

733805
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

124442
units: metaid_0000003
value: 1.0
name: k1_ant
type: LocalParameter

124209
units: metaid_0000004
value: 6.0
name: k52
type: LocalParameter

metaid_0000049
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_2AR_Gq
type: Species

124404
units: metaid_0000003
value: 13.33
name: k4
type: LocalParameter

124337
units: metaid_0000005
value: 5.0
name: Km17_2a
type: LocalParameter

735236
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000218
kinetic law: 738192
product: 738180
reactant: 738168
reactant: 738156
fast: false
reversible: true
name: Srcbinds_PIP3
type: Reaction

metaid_0000007
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

734702
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

124288
units: metaid_0000004
value: 0.1
name: k58r_2a
type: LocalParameter

124446
units: metaid_0000003
value: 1.0
name: kant_KRbindsG
type: LocalParameter

metaid_0000096
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boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxPTEN_PIP3
type: Species

metaid_0000132
kinetic law: 734203
product: 734191
product: 734178
reactant: 734166
notes: releaseRafstar_MEKPP
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reversible: false
name: v47_89
type: Reaction

735650
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

124426
units: metaid_0000004
value: 1.0
name: k78
type: LocalParameter

736549
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

124445
units: metaid_0000004
value: 2.5
name: k2r_ant
type: LocalParameter

736633
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

124405
units: metaid_0000004
value: 0.1
name: k4r
type: LocalParameter

736791
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

metaid_0000048
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.4168E-6
initial amount: NaN
in compartment: metaid_0000007
name: cpxRGS4_Gq_a_GTP
type: Species

metaid_0000008
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.01
initial amount: NaN
in compartment: metaid_0000007
name: TCB
type: Species

metaid_0000230
kinetic law: 738675
product: 738663
reactant: 738651
reactant: 738639
notes: Abinds_RGi
fast: false
reversible: true
name: HT_binds1ARGi
type: Reaction

124336
units: metaid_0000004
value: 10.0
name: k16_2a
type: LocalParameter

metaid_0000217
kinetic law: 738144
product: 738132
product: 738120
reactant: 738108
notes: releasePIP3
fast: false
reversible: false
name: releasePI3Kstar
type: Reaction

124289
units: metaid_0000003
value: 1.2E-4
name: k61_2a
type: LocalParameter

738457
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

734518
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000095
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.164
initial amount: NaN
in compartment: metaid_0000007
name: PTEN
type: Species

metaid_0000133
kinetic law: 734251
product: 734239
reactant: 734227
reactant: 734215
notes: Rafstarbinds_MEKP
fast: false
reversible: true
name: v46_88
type: Reaction

124425
units: metaid_0000003
value: 21.0
name: k39r
type: LocalParameter

735334
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

124444
units: metaid_0000003
value: 1.0
name: k2_ant
type: LocalParameter

124335
units: metaid_0000005
value: 40.13
name: Km16_2a
type: LocalParameter

metaid_0000047
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.019994
initial amount: NaN
in compartment: metaid_0000007
name: RGS4
type: Species

733841
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

124406
units: metaid_0000003
value: 6.0
name: k6
type: LocalParameter

124225
units: metaid_0000004
value: 0.1
name: k74r
type: LocalParameter

124206
units: metaid_0000003
value: 10.0
name: k68
type: LocalParameter

metaid_0000025
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0054982
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKPP_MKP
type: Species

124428
units: metaid_0000003
value: 0.1
name: k38r
type: LocalParameter

736585
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

734130
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000005
unit: 733744
unit: 733732
name: M
type: SBMLUnitsDef

738036
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

735818
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

737673
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

739266
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

124226
units: metaid_0000004
value: 0.125
name: k46
type: LocalParameter

735140
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

124286
units: metaid_0000005
value: 20.0
name: Km57_2a
type: LocalParameter

739314
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

124224
units: metaid_0000003
value: 1.0
name: k74
type: LocalParameter

738903
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

739604
stoichiometry: 1.0
species: metaid_0000110
type: SpeciesReference

124205
units: metaid_0000004
value: 0.5
name: k69
type: LocalParameter

737976
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

metaid_0000026
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.489E-5
initial amount: NaN
in compartment: metaid_0000007
name: PLA2star
type: Species

738372
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

735902
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

124427
units: metaid_0000004
value: 0.0015
name: k38
type: LocalParameter

metaid_0000006
unit: 733780
unit: 733768
unit: 733756
name: Mps
type: SBMLUnitsDef

737358
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

736307
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

736839
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

737021
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

735128
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

124287
units: metaid_0000003
value: 0.0012
name: k58_2a
type: LocalParameter

738228
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

124208
units: metaid_0000004
value: 6.0
name: k76
type: LocalParameter

metaid_0000023
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 3.1036E-5
initial amount: NaN
in compartment: metaid_0000007
name: PLA2star_Ca
type: Species

735926
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

734046
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

735529
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000003
unit: 733708
unit: 733696
unit: 733684
name: 1/(M*sec)
type: SBMLUnitsDef

124228
units: metaid_0000003
value: 1.92
name: k55
type: LocalParameter

734323
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

124207
units: metaid_0000004
value: 1.0
name: k68r
type: LocalParameter

733998
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

736924
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

736059
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

739665
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000099
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: HT1AR_internal
type: Species

metaid_0000024
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.2445E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLA2_Ca
type: Species

737613
stoichiometry: 1.0
species: metaid_0000081
type: SpeciesReference

739713
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

124429
units: metaid_0000005
value: 2.564
name: kmdd
type: LocalParameter

739050
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

metaid_0000004
unit: 733720
name: 1/sec
type: SBMLUnitsDef

124227
units: metaid_0000004
value: 6.0
name: k56
type: LocalParameter

738300
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

739376
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

738012
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

736561
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

737697
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

124182
units: metaid_0000004
value: 24.0
name: k53r
type: LocalParameter

metaid_0000029
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 3.5823E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLA2
type: Species

735068
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

735164
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

739640
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

737880
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000212
kinetic law: 737904
modifier: 737892
product: 737880
reactant: 737868
fast: false
reversible: false
name: PKC_AAact_Raf
type: Reaction

124282
units: metaid_0000004
value: 8.6348
name: k23r_2a
type: LocalParameter

metaid_0000239
kinetic law: 739146
product: 739134
product: 739122
reactant: 739110
notes: basalGi_a_GTPsplit
fast: false
reversible: false
name: basal_Gi_a_GTP_split_rx
type: Reaction

736199
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

737419
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

734689
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

124229
units: metaid_0000004
value: 24.0
name: k55r
type: LocalParameter

124283
units: metaid_0000004
value: 120.0
name: k57_2a
type: LocalParameter

733938
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000211
kinetic law: 737856
modifier: 737843
product: 737831
reactant: 737819
fast: false
reversible: false
name: PKC_Ca_AAactRaf
type: Reaction

736172
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000027
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 2.5313E-7
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKPP_PLA2star
type: Species

124204
units: metaid_0000003
value: 1.1
name: k70r
type: LocalParameter

124180
units: metaid_0000003
value: 1.9161
name: k53
type: LocalParameter

metaid_0000237
kinetic law: 739038
product: 739026
reactant: 739014
reactant: 739002
notes: Gi_a_GTPbindsRGS
fast: false
reversible: true
name: RGSfor1A_binds_Gia_GTP
type: Reaction

736960
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

124203
units: metaid_0000004
value: 0.086
name: k70
type: LocalParameter

metaid_0000210
kinetic law: 737807
modifier: 737794
product: 737781
reactant: 737769
fast: false
reversible: false
name: PKC_Ca_DAGactive_actRaf
type: Reaction

735468
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

124280
units: metaid_0000004
value: 0.5
name: k21r_2a
type: LocalParameter

metaid_0000028
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.034739
initial amount: NaN
in compartment: metaid_0000007
name: Ca
type: Species

738324
stoichiometry: 1.0
species: metaid_0000093
type: SpeciesReference

733974
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

736501
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

124202
units: metaid_0000004
value: 20.2
name: k63r
type: LocalParameter

735866
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000238
fast: false
reactant: 739050
product: 739074
notes: RGS4deact_GiaGTP
name: dissociation_RGS_Gia_GTPcpx
product: 739062
kinetic law: 739098
type: Reaction
product: 739086
reversible: false

735505
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

124281
units: metaid_0000003
value: 0.008
name: k23_2a
type: LocalParameter

W3 CDTF: Wed Oct 07 15:45:53 BST 2009

orgname: EMBL-EBI

n:
  given: Lukas
  family: Endler

orgname: Weill Medical College of Cornell University

W3 CDTF: Wed Oct 07 15:45:53 BST 2009

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

n:
  given: Chiung-wen Violet
  family: Chang