214960
constant: true
units: 725130
value: 0.023
name: kdact
type: Parameter

214959
constant: false
units: dimensionless
value: NaN
name: Heav
type: Parameter

725106
unit: 725118
name: minute
type: SBMLUnitsDef

214964
constant: false
units: dimensionless
value: 0.0
name: Xic_Cdk2_CycE
type: Parameter

214978
constant: true
units: 725130
value: 0.01
name: kxdeg
type: Parameter

214981
constant: true
value: 0.001
name: epsilon
type: Parameter

214974
constant: true
units: 725130
value: 1.0E-4
name: koff
type: Parameter

214984
constant: true
units: dimensionless
value: 0.4
name: L
type: Parameter

214971
constant: true
units: 725130
value: 1.5
name: kwee
type: Parameter

214968
constant: false
units: dimensionless
value: 0.0
name: Xicrem
type: Parameter

214955
constant: true
units: 725130
value: 0.6
name: kiinact
type: Parameter

214941
constant: true
units: dimensionless
value: 8.0
name: Wee1_total
type: Parameter

214951
constant: true
units: dimensionless
value: 0.01
name: Jiact
type: Parameter

214975
constant: true
units: 725130
value: 0.1
name: kassoc
type: Parameter

214939
constant: true
units: dimensionless
value: 0.01
name: Jwact
type: Parameter

214961
constant: true
units: dimensionless
value: 0.3
name: theta
type: Parameter

214965
constant: false
units: dimensionless
value: 0.0
name: Xic_PCdk2_CycE
type: Parameter

214958
constant: false
units: dimensionless
value: 0.0
name: Deg_a
type: Parameter

214980
constant: true
units: dimensionless
value: 0.0
name: Deg
type: Parameter

725154
unit: 725166
name: time
type: SBMLUnitsDef

214979
constant: false
units: dimensionless
value: NaN
name: phi
type: Parameter

214970
constant: false
units: dimensionless
value: NaN
name: Xic_total
type: Parameter

214940
constant: true
units: dimensionless
value: 0.01
name: Jwinact
type: Parameter

214954
constant: true
units: 725130
value: 0.15
name: kiact
type: Parameter

214969
constant: false
units: dimensionless
value: NaN
name: Cyc_total
type: Parameter

214950
constant: false
units: dimensionless
value: 0.6
name: Kin_a
type: Parameter

214938
constant: false
units: dimensionless
value: 1.02
name: Wee1_a
type: Parameter

214966
constant: false
units: dimensionless
value: 0.0
name: Xic_Cdk2_CycErem
type: Parameter

214957
constant: false
units: dimensionless
value: 0.0
name: PCdk2_CycErem
type: Parameter

214962
constant: false
units: dimensionless
value: NaN
name: x
type: Parameter

MODEL0913242281
parameter: 214983
rule: 214932
parameter: 214981
parameter: 214943
rule: 214923
parameter: 214941
parameter: 214975
parameter: 214973
parameter: 214971
parameter: 214972
rule: 214925
units def: 725154
rule: 214918
parameter: 214960
time units: 725154
parameter: 214939
rule: 214928
parameter: 214959
parameter: 214955
parameter: 214978
parameter: 214938
parameter: 214958
rule: 214921
notes: This a model from the article: A kinetic model of the cyclin E/Cdk2 developmental timer in Xenopus laevis embryos. Ciliberto A, Petrus MJ, Tyson JJ, Sible JC. Biophys Chem 2003 Jul 1;104(3):573-89 12914904 , Abstract: Early cell cycles of Xenopus laevis embryos are characterized by rapid oscillations in the activity of two cyclin-dependent kinases. Cdk1 activity peaks at mitosis, driven by periodic degradation of cyclins A and B. In contrast, Cdk2 activity oscillates twice per cell cycle, despite a constant level of its partner, cyclin E. Cyclin E degrades at a fixed time after fertilization, normally corresponding to the midblastula transition. Based on published data and new experiments, we constructed a mathematical model in which: (1) oscillations in Cdk2 activity depend upon changes in phosphorylation, (2) Cdk2 participates in a negative feedback loop with the inhibitory kinase Wee1; (3) cyclin E is cooperatively removed from the oscillatory system; and (4) removed cyclin E is degraded by a pathway activated by cyclin E/Cdk2 itself. The model's predictions about embryos injected with Xic1, a stoichiometric inhibitor of cyclin E/Cdk2, were experimentally validated. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Ciliberto A, Petrus MJ, Tyson JJ, Sible JC. (2003) - version03 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable…
area units: area
parameter: 214956
parameter: 214954
parameter: 214966
rule: 214933
parameter: 214984
parameter: 214982
parameter: 214969
volume units: 970346
parameter: 214980
parameter: 214942
parameter: 214965
parameter: 214940
parameter: 214963
compartment: 214915
rule: 214935
rule: 214926
units def: 725130
rule: 214919
type: SBMLModel
substance units: 608838
length unit: 335510
parameter: 214979
parameter: 214977
parameter: 214937
parameter: 214957
rule: 214931
rule: 214922
parameter: 214953
parameter: 214976
rule: 214930
parameter: 214951
parameter: 214936
parameter: 214974
parameter: 214968
parameter: 214970
rule: 214934
is described by: http://identifiers.org/pubmed/12914904
parameter: 214964
parameter: 214950
parameter: 214962
rule: 214924
rule: 214917
parameter: 214961
rule: 214927
name: Ciliberto2003_CyclinECdk2Timer
rule: 214929
curated: false
units def: 725106
rule: 214920
parameter: 214967

725118
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

214983
constant: true
units: dimensionless
value: 4.0
name: n
type: Parameter

214972
constant: true
units: 725130
value: 0.1
name: k25A
type: Parameter

214976
constant: true
units: 725130
value: 0.001
name: kdissoc
type: Parameter

214943
constant: true
units: 725130
value: 1.5
name: kwinact
type: Parameter

214937
constant: false
units: dimensionless
value: 0.94
name: PCdk2_CycE
type: Parameter

214953
constant: true
units: dimensionless
value: 0.01
name: Jiinact
type: Parameter

725130
unit: 725142
name: first_order_rate_constant
type: SBMLUnitsDef

214967
constant: false
units: dimensionless
value: 0.0
name: Xic_PCdk2_CycErem
type: Parameter

725142
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

214956
constant: false
units: dimensionless
value: 0.0
name: Cdk2_CycErem
type: Parameter

214963
constant: false
units: dimensionless
value: 3.0
name: Xic
type: Parameter

214982
constant: false
units: dimensionless
value: NaN
name: pool
type: Parameter

214973
constant: true
units: 725130
value: 0.02
name: kon
type: Parameter

214915
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

214977
constant: true
units: 725130
value: 0.017
name: kedeg
type: Parameter

214942
constant: true
units: 725130
value: 0.75
name: kwact
type: Parameter

725166
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

214936
constant: false
units: dimensionless
value: 0.06
name: Cdk2_CycE
type: Parameter