982270
constant: false
units: 690212
value: 11.3
name: V
type: Parameter

982264
constant: true
units: 690175
value: 3.0
name: Crpt
type: Parameter

982292
constant: false
units: 690175
value: 0.64
name: PRO
type: Parameter

982258
constant: true
units: 690175
value: 10.0
name: Kdsm
type: Parameter

690187
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

690261
unit: 690273
name: first_order_rate_constant
type: SBMLUnitsDef

982310
constant: true
units: 690175
value: 150.0
name: Kmptr
type: Parameter

982254
constant: true
units: dimensionless
value: 0.013
name: Ko
type: Parameter

982303
constant: true
units: 690261
value: 0.01
name: Kcb
type: Parameter

982274
constant: false
units: 690212
value: 10.0
name: W
type: Parameter

690334
exponent: -2.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

982260
constant: true
units: 690212
value: 10.0
name: Vdsm
type: Parameter

982308
constant: true
units: 690212
value: 500.0
name: Vmptr
type: Parameter

690285
unit: 690297
name: minute_2
type: SBMLUnitsDef

982299
constant: false
units: 690212
value: NaN
name: LH_CORT
type: Parameter

690249
exponent: -1.0
scale: 0
multipler: 1.0
kind: GRAM
type: SBMLUnit

982295
constant: false
units: 690175
value: 0.64
name: HYPR
type: Parameter

982268
constant: true
units: dimensionless
value: 4.0
name: n
type: Parameter

690395
exponent: -2.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

982278
constant: false
units: 690175
value: 532.0
name: CHOC
type: Parameter

690419
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

690018
unit: 690042
unit: 690030
name: nanomolar
type: SBMLUnitsDef

690054
unit: 690079
unit: 690066
name: per_nanomolar
type: SBMLUnitsDef

690383
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

690309
unit: 690346
unit: 690334
unit: 690322
name: nmol2_min2_g2
type: SBMLUnitsDef

982271
constant: true
units: 690285
value: 0.052
name: P
type: Parameter

690224
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

982259
constant: true
units: 690212
value: 6.0
name: Vmsm
type: Parameter

982300
constant: true
units: 690261
value: 1.65
name: Lmtr
type: Parameter

690030
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

690200
exponent: -1.0
scale: 0
multipler: 1.0
kind: GRAM
type: SBMLUnit

982304
constant: true
units: 690261
value: 3.3E-4
name: Kcf
type: Parameter

982255
constant: true
units: 690054
value: 0.01
name: Ka
type: Parameter

982275
constant: true
units: 690309
value: 8.0
name: T
type: Parameter

690163
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

982298
constant: true
units: 690261
value: 0.724
name: LH
type: Parameter

982294
constant: true
units: dimensionless
value: 0.5
name: HA
type: Parameter

982279
constant: false
units: 690175
value: 11.3
name: CHOM
type: Parameter

982284
constant: true
units: 690261
value: 125.0
name: D
type: Parameter

690115
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

982288
constant: true
units: 690261
value: 76.0
name: S
type: Parameter

982272
constant: true
units: 690261
value: 0.042
name: Q
type: Parameter

982228
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

982290
constant: false
units: 690175
value: 3.03
name: CHON
type: Parameter

690346
exponent: -2.0
scale: 0
multipler: 1.0
kind: GRAM
type: SBMLUnit

982262
constant: false
units: 690091
value: NaN
name: ACTH
type: Parameter

690066
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

982276
constant: true
units: 690261
value: 0.0015
name: U
type: Parameter

690175
unit: 690200
unit: 690187
name: nmol_g
type: SBMLUnitsDef

690273
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

982256
constant: true
units: 690054
value: 1000.0
name: Kb
type: Parameter

690139
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

690042
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

690006
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

982266
constant: true
units: dimensionless
value: 80.0
name: K
type: Parameter

690407
unit: 690419
name: time
type: SBMLUnitsDef

982306
constant: true
units: 690212
value: 1890.0
name: Vm
type: Parameter

MODEL0912835813
units def: 690018
parameter: 982303
parameter: 982295
rule: 982241
parameter: 982311
parameter: 982254
rule: 982250
parameter: 982252
parameter: 982262
parameter: 982272
rule: 982240
rule: 982233
parameter: 982260
parameter: 982270
type: SBMLModel
rule: 982234
length unit: 335510
units def: 690151
rule: 982236
parameter: 982268
parameter: 982278
parameter: 982288
parameter: 982298
parameter: 982286
parameter: 982296
parameter: 982280
parameter: 982290
parameter: 982306
units def: 690261
volume units: 970346
units def: 690212
parameter: 982304
units def: 690127
rule: 982242
parameter: 982312
parameter: 982255
rule: 982246
parameter: 982263
curated: false
parameter: 982283
rule: 982232
parameter: 982271
rule: 982249
rule: 982248
units def: 690309
rule: 982238
units def: 690407
units def: 690175
parameter: 982279
parameter: 982299
parameter: 982258
rule: 982245
parameter: 982291
parameter: 982256
parameter: 982266
parameter: 982276
compartment: 982228
parameter: 982307
parameter: 982264
parameter: 982274
parameter: 982284
parameter: 982294
parameter: 982282
rule: 982244
units def: 690285
rule: 982231
units def: 689994
parameter: 982302
substance units: 608838
parameter: 982300
time units: 690407
is described by: http://identifiers.org/pubmed/6326602
units def: 690054
rule: 982237
parameter: 982292
parameter: 982308
area units: area
notes: This a model from the article: A mechanistic model of ACTH-stimulated cortisol secretion. Dempsher DP, Gann DS, Phair RD. Am J Physiol 1984 Apr;246(4 Pt 2):R587-96 6326602 , Abstract: Adrenal secretory rates of cortisol and arterial concentrations of adrenocorticotropin (ACTH) were measured in conscious trained dogs subjected to intravenous infusion of ACTH. To investigate the causal relation of ACTH to the secretion of cortisol, a mechanistic mathematical model based on current hypotheses of adrenocortical function was constructed and tested. It is widely believed that ACTH stimulates cortisol secretion through adenosine 3',5'-cyclic monophosphate (cAMP), which provides substrate cholesterol by activating cholesterol ester hydrolase and facilitating transport of cholesterol to the side-chain cleavage enzyme. In addition, cholesterol modulates its own synthesis by inhibiting beta-hydroxy-beta-methylglutaryl (HMG)-CoA reductase in the adrenocortical cell. These and other steps in the biosynthetic reaction sequence were described using differential equations subject to the additional constraints imposed by available measurements of intracellular quantities. The resulting model is consistent with many of the known characteristics of the canine adrenal response to ACTH. In this model, steady-state nonlinearities arise from cooperative binding of cAMP to its receptor protein and saturation of mitochondrial pregnenolone transport. The transient response is dominated by a depletable pool of intracellular free cholesterol. Other inferences based on the model are presented, and a quantifiable cellular basis for increased adrenal sensitivity to ACTH is proposed. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Dempsher DP, Gann DS, Phair RD. (1984) - version03 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model origin…
name: Dempsher1984_ACTH_CortisolSecretion
parameter: 982259

690322
exponent: 2.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

982287
constant: true
units: 690359
value: 3.0
name: R
type: Parameter

690297
exponent: -2.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

689994
unit: 690006
name: nanomole
type: SBMLUnitsDef

982252
constant: false
units: 690175
value: 0.95
name: cAMP
type: Parameter

690212
unit: 690249
unit: 690236
unit: 690224
name: flux
type: SBMLUnitsDef

982283
constant: true
units: 690359
value: 6.25
name: C
type: Parameter

982311
constant: true
units: 690261
value: 16.4
name: AH
type: Parameter

690359
unit: 690395
unit: 690383
unit: 690371
name: g_nmol_min2
type: SBMLUnitsDef

690103
exponent: 1.0
scale: -12
multipler: 1.0
kind: MOLE
type: SBMLUnit

982302
constant: true
units: 690261
value: 10.0
name: Kbac
type: Parameter

982291
constant: false
units: 690175
value: 6.56
name: PREG
type: Parameter

982263
constant: false
units: 690175
value: NaN
name: IS
type: Parameter

690371
exponent: 1.0
scale: 0
multipler: 1.0
kind: GRAM
type: SBMLUnit

690079
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

690236
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

982267
constant: true
units: 690175
value: 2.11
name: Kd
type: Parameter

982307
constant: true
units: 690175
value: 270.0
name: Km
type: Parameter

982296
constant: false
units: 690175
value: 5.2
name: CORT
type: Parameter

982286
constant: false
units: 690261
value: 0.37
name: Kfor
type: Parameter

690091
unit: 690115
unit: 690103
name: picomolar
type: SBMLUnitsDef

690127
unit: 690139
name: minute
type: SBMLUnitsDef

982282
constant: false
units: 690261
value: 0.446
name: Kmtr
type: Parameter

982280
constant: false
units: 690175
value: 3000.0
name: CHOL
type: Parameter

690151
unit: 690163
name: hour
type: SBMLUnitsDef

982312
constant: true
units: 690261
value: 16.4
name: HY
type: Parameter