889822
constant: true
units: 634920
value: 357.0
name: t1
type: Parameter

889855
constant: true
units: dimensionless
value: 5.0
name: n4
type: Parameter

634968
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

889872
constant: false
units: 635004
value: NaN
name: inject
type: Parameter

635052
unit: 635064
name: hour
type: SBMLUnitsDef

635016
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

889851
constant: true
units: 635076
value: 40.0
name: k3
type: Parameter

889818
constant: true
units: dimensionless
value: 20.0
name: GHS
type: Parameter

889845
constant: true
units: 635004
value: 2200.0
name: kr2
type: Parameter

889837
constant: true
units: 634884
value: 10.0
name: t5
type: Parameter

634896
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

635112
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

635076
unit: 635088
name: first_order_rate_constant
type: SBMLUnitsDef

889861
constant: true
units: dimensionless
value: 100.0
name: g2
type: Parameter

634944
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

889827
constant: true
units: dimensionless
value: 2.0
name: g0
type: Parameter

889875
constant: true
units: 635004
value: 10000.0
name: C
type: Parameter

634932
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM
type: SBMLUnit

634992
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

889821
constant: true
units: 634956
value: 600.0
name: kr1
type: Parameter

889852
constant: true
units: 635004
value: 63000.0
name: kr3
type: Parameter

889816
constant: false
units: 634884
value: 0.0
name: GH
type: Parameter

889842
constant: false
units: 634920
value: 0.0
name: SRIF_ArC
type: Parameter

889819
constant: true
units: 635076
value: 3.0
name: k1
type: Parameter

889836
constant: true
units: 635004
value: 20400.0
name: kr4
type: Parameter

889831
constant: true
units: 634920
value: 10.0
name: t2
type: Parameter

889846
constant: true
units: 634920
value: 400.0
name: t3
type: Parameter

635040
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

MODEL0912096133
is described by: http://identifiers.org/pubmed/17185408
rule: 889803
parameter: 889863
parameter: 889855
parameter: 889830
parameter: 889822
parameter: 889836
volume units: volume
parameter: 889816
area units: area
parameter: 889873
parameter: 889845
parameter: 889869
parameter: 889849
parameter: 889878
units def: 635052
parameter: 889839
rule: 889814
type: SBMLModel
parameter: 889872
parameter: 889819
parameter: 889852
curated: false
parameter: 889824
parameter: 889821
substance units: 608838
parameter: 889825
compartment: 889801
rule: 889805
units def: 634956
parameter: 889875
parameter: 889867
parameter: 889842
parameter: 889854
parameter: 889834
rule: 889812
rule: 889811
parameter: 889848
parameter: 889828
parameter: 889857
length unit: 027038
parameter: 889860
notes: This a model from the article: Model-projected mechanistic bases for sex differences in growth hormone regulation in humans. Farhy LS, Bowers CY, Veldhuis JD. Am J Physiol Regul Integr Comp Physiol 2007 Apr;292(4):R1577-93 17185408 , Abstract: Models of physiological systems facilitate rational experimental design, inference, and prediction. A recent construct of regulated growth hormone (GH) secretion interlinks the actions of GH-releasing hormone (GHRH), somatostatin (SRIF), and GH secretagogues (GHS) with GH feedback in the rat (Farhy LS, Veldhuis JD. Am J Physiol Regul Integr Comp Physiol 288: R1649-R1663, 2005). In contrast, no comparable formalism exists to explicate GH dynamics in any other species. The present analyses explore whether a unifying model structure can represent species- and sex-defined distinctions in the human and rodent. The consensus principle that GHRH and GHS synergize in vivo but not in vitro was explicable by assuming that GHS 1) evokes GHRH release from the brain, 2) opposes inhibition by SRIF both in the hypothalamus and on the pituitary gland, and 3) stimulates pituitary GH release directly and additively with GHRH. The gender-selective principle that GH pulses are larger and more irregular in women than men was conferrable by way of 4) higher GHRH potency and 5) greater GHS efficacy. The overall construct predicts GHRH/GHS synergy in the human only in the presence of SRIF when the brain-pituitary nexus is intact, larger and more irregular GH pulses in women, and observed gender differences in feedback by GH and the single and paired actions of GHRH, GHS, and SRIF. The proposed model platform should enhance the framing and interpretation of novel clinical hypotheses and create a basis for interspecies generalization of GH-axis regulation. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Farhy LS, Bowers CY, Veldhuis JD. (2007) - version03 The original CellML model was created…
parameter: 889858
time units: 635100
units def: 635004
units def: 634920
rule: 889815
parameter: 889818
parameter: 889851
parameter: 889831
parameter: 889870
parameter: 889843
parameter: 889864
parameter: 889861
parameter: 889876
parameter: 889833
parameter: 889837
rule: 889806
rule: 889809
rule: 889808
parameter: 889866
parameter: 889846
units def: 635076
name: Farhy2007_hGHregulation
parameter: 889827
units def: 635100
units def: 634884
parameter: 889840

889801
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

889866
constant: true
units: dimensionless
value: 3.0
name: ng1
type: Parameter

889876
constant: true
units: 635052
value: 2.0
name: onset
type: Parameter

889860
constant: true
units: dimensionless
value: 90000.0
name: g1
type: Parameter

635100
unit: 635112
name: time
type: SBMLUnitsDef

889824
constant: true
units: dimensionless
value: 5.0
name: n1
type: Parameter

889858
constant: false
units: dimensionless
value: NaN
name: F2_GHS
type: Parameter

635064
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

889848
constant: true
units: dimensionless
value: 2.0
name: n3
type: Parameter

889834
constant: true
units: 635076
value: 25.0
name: k4
type: Parameter

889843
constant: true
units: 635076
value: 25.0
name: k2
type: Parameter

635004
unit: 635040
unit: 635028
unit: 635016
name: pg_ml_hr
type: SBMLUnitsDef

889870
constant: false
units: 635004
value: NaN
name: dghr_GHRH_dt
type: Parameter

889863
constant: true
units: dimensionless
value: 390.0
name: tg1
type: Parameter

889830
constant: true
units: dimensionless
value: 200.0
name: tg0
type: Parameter

634920
unit: 634944
unit: 634932
name: pg_ml
type: SBMLUnitsDef

635028
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

635088
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

889825
constant: true
units: dimensionless
value: 2.0
name: n2
type: Parameter

889857
constant: false
units: dimensionless
value: NaN
name: F1_GHS
type: Parameter

634980
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

634884
unit: 634908
unit: 634896
name: ng_ml
type: SBMLUnitsDef

889873
constant: true
units: 635076
value: 15.0
name: kghr
type: Parameter

889839
constant: true
units: dimensionless
value: 2.0
name: n5
type: Parameter

634956
unit: 634992
unit: 634980
unit: 634968
name: ng_ml_hr
type: SBMLUnitsDef

889867
constant: true
units: dimensionless
value: 2.0
name: ng2
type: Parameter

889869
constant: false
units: 634920
value: 0.0
name: ghr_GHRH
type: Parameter

889854
constant: true
units: 634920
value: 28.0
name: t4
type: Parameter

889840
constant: true
units: 635004
value: 900.0
name: S_basal
type: Parameter

889833
constant: false
units: 634920
value: 0.0
name: SRIF_PeV
type: Parameter

889849
constant: false
units: 634920
value: 0.0
name: GHRH
type: Parameter

634908
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

889828
constant: true
units: dimensionless
value: 2.9
name: ng0
type: Parameter

889864
constant: true
units: dimensionless
value: 10000.0
name: tg2
type: Parameter

889878
constant: true
units: 635052
value: 0.2
name: duration
type: Parameter