014651
constant: false
units: 630581
value: NaN
name: I_PM
type: Parameter

014627
constant: false
units: 630581
value: NaN
name: I_iCa
type: Parameter

630412
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scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

630449
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

014657
constant: false
units: 630581
value: NaN
name: I_Na
type: Parameter

630461
unit: 630485
unit: 630473
name: per_micromolar
type: SBMLUnitsDef

630811
unit: 630847
unit: 630835
unit: 630823
name: flux
type: SBMLUnitsDef

014637
constant: false
units: 630400
value: NaN
name: ECa
type: Parameter

014647
constant: true
units: 630557
value: 220.0
name: gNSCC_Na_
type: Parameter

014661
constant: true
units: 630424
value: 10000.0
name: KNa
type: Parameter

014739
constant: false
units: 630787
value: NaN
name: alpha_phi3
type: Parameter

014731
constant: true
units: 630763
value: 300.0
name: g_beta
type: Parameter

014794
constant: true
units: dimensionless
value: 1.0
name: gamma_S2
type: Parameter

014761
constant: false
units: 630424
value: 0.22
name: CMT
type: Parameter

630701
exponent: -1.0
scale: -21
multipler: 1.0
kind: MOLE
type: SBMLUnit

014745
constant: false
units: dimensionless
value: NaN
name: lambda_MT_S1
type: Parameter

014711
constant: true
units: 630811
value: 0.0
name: r_2
type: Parameter

014699
constant: false
units: 630811
value: NaN
name: JIPR
type: Parameter

630545
exponent: 1.0
scale: -12
multipler: 1.0
kind: FARAD
type: SBMLUnit

630641
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

014719
constant: false
units: 630763
value: NaN
name: phi1
type: Parameter

014803
constant: true
units: 630424
value: 0.12
name: KNSCC
type: Parameter

630617
exponent: 1.0
scale: -15
multipler: 1.0
kind: AMPERE
type: SBMLUnit

014705
constant: true
units: 630763
value: 0.0
name: k1
type: Parameter

630751
exponent: -1.0
scale: 0
multipler: 1.0
kind: KELVIN
type: SBMLUnit

014667
constant: true
units: 630763
value: 100000.0
name: VSERCA
type: Parameter

014681
constant: true
units: 630424
value: 10.0
name: KMCU
type: Parameter

014752
constant: false
units: dimensionless
value: NaN
name: lambda_MT_S2
type: Parameter

630677
unit: 630701
unit: 630689
name: femtocoulomb_per_zeptomole
type: SBMLUnitsDef

014724
constant: false
units: 630763
value: NaN
name: phi2
type: Parameter

014691
constant: true
units: 630811
value: 0.5
name: VNCX
type: Parameter

630823
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

630473
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

630593
exponent: 1.0
scale: -12
multipler: 1.0
kind: AMPERE
type: SBMLUnit

630400
unit: 630412
name: millivolt
type: SBMLUnitsDef

014677
constant: false
units: 630811
value: NaN
name: JMCU
type: Parameter

014671
constant: true
units: 630461
value: 3.57
name: A4
type: Parameter

630739
exponent: -1.0
scale: -21
multipler: 1.0
kind: MOLE
type: SBMLUnit

014764
constant: false
units: dimensionless
value: NaN
name: fm
type: Parameter

630775
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

014659
constant: true
units: 630605
value: 15000.0
name: gNa
type: Parameter

014663
constant: true
units: dimensionless
value: 4.0
name: hNa
type: Parameter

014639
constant: false
units: 630581
value: NaN
name: I_NSCC_Ca
type: Parameter

014797
constant: true
units: dimensionless
value: 200.0
name: gamma_MT
type: Parameter

014806
constant: true
units: 630400
value: 0.0
name: ENSCC
type: Parameter

014645
constant: false
units: 630581
value: NaN
name: I_NSCC_Na
type: Parameter

630424
unit: 630449
unit: 630436
name: micromolar
type: SBMLUnitsDef

014733
constant: true
units: dimensionless
value: 2.0
name: h_beta
type: Parameter

630557
unit: 630569
name: picosiemens
type: SBMLUnitsDef

014782
constant: true
units: 630424
value: 1800.0
name: CO
type: Parameter

014743
constant: false
units: 630424
value: 0.12
name: CS1
type: Parameter

014713
constant: true
units: 630763
value: 750.0
name: r4
type: Parameter

014741
constant: false
units: 630763
value: NaN
name: beta_phi3
type: Parameter

014631
constant: true
units: 630533
value: 20.0
name: Cm
type: Parameter

014697
constant: true
units: 630763
value: 0.04
name: mu_S1S2
type: Parameter

014703
constant: true
units: 630811
value: 6.4
name: k_1
type: Parameter

630605
unit: 630617
name: femtoampere
type: SBMLUnitsDef

630521
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scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

630835
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scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

014683
constant: false
units: dimensionless
value: NaN
name: epsilon_INH
type: Parameter

014750
constant: false
units: 630424
value: 0.023
name: CS2
type: Parameter

014779
constant: true
units: kelvin
value: 310.16
name: T
type: Parameter

014665
constant: false
units: 630811
value: NaN
name: JSERCA
type: Parameter

630485
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

630581
unit: 630593
name: picoampere
type: SBMLUnitsDef

014722
constant: false
units: 630811
value: NaN
name: phi_1
type: Parameter

014759
constant: false
units: 630424
value: 203.0
name: CER
type: Parameter

014679
constant: true
units: 630811
value: 800.0
name: VMCU
type: Parameter

630689
exponent: 1.0
scale: -15
multipler: 1.0
kind: COULOMB
type: SBMLUnit

014643
constant: false
units: 630557
value: NaN
name: gNSCC_Ca
type: Parameter

014756
constant: false
units: dimensionless
value: NaN
name: lambda_S1_S2
type: Parameter

014785
constant: true
units: 630424
value: 1.0
name: P
type: Parameter

014735
constant: true
units: 630787
value: 0.02
name: g_alpha
type: Parameter

014766
constant: true
units: 630424
value: 0.01
name: Km
type: Parameter

014715
constant: true
units: 630424
value: 36.0
name: R1
type: Parameter

630509
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

014729
constant: false
units: dimensionless
value: 0.787
name: H
type: Parameter

014633
constant: false
units: 630581
value: NaN
name: I_Ca
type: Parameter

630653
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

014776
constant: true
units: 630677
value: 0.09649
name: F
type: Parameter

014709
constant: true
units: 630763
value: 200.0
name: r2
type: Parameter

MODEL0912044015
parameter: 014641
rule: 014607
rule: 014589
rule: 014571
parameter: 014722
rule: 014561
parameter: 014681
parameter: 014671
parameter: 014724
parameter: 014683
rule: 014585
rule: 014595
parameter: 014699
parameter: 014719
parameter: 014806
compartment: 014554
parameter: 014649
parameter: 014766
parameter: 014756
rule: 014605
rule: 014583
parameter: 014774
rule: 014563
curated: false
notes: This a model from the article: A biophysically based mathematical model of unitary potential activity in interstitial cells of Cajal. Faville RA, Pullan AJ, Sanders KM, Smith NP. Biophys J 2008 Jul;95(1):88-104 18339738 , Abstract: Unitary potential (UP) depolarizations are the basic intracellular events responsible for pacemaker activity in interstitial cells of Cajal (ICCs), and are generated at intracellular sites termed "pacemaker units". In this study, we present a mathematical model of the transmembrane ion flows and intracellular Ca(2+) dynamics from a single ICC pacemaker unit acting at near-resting membrane potential. This model quantitatively formalizes the framework of a novel ICC pacemaking mechanism that has recently been proposed. Model simulations produce spontaneously rhythmic UP depolarizations with an amplitude of approximately 3 mV at a frequency of 0.05 Hz. The model predicts that the main inward currents, carried by a Ca(2+)-inhibited nonselective cation conductance, are activated by depletion of sub-plasma-membrane [Ca(2+)] caused by sarcoendoplasmic reticulum calcium ATPase Ca(2+) sequestration. Furthermore, pacemaker activity predicted by our model persists under simulated voltage clamp and is independent of [IP(3)] oscillations. The model presented here provides a basis to quantitatively analyze UP depolarizations and the biophysical mechanisms underlying their production. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Faville RA, Pullan AJ, Sanders KM, Smith NP. (2008) - version02 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to t…
is described by: http://identifiers.org/pubmed/18339738
parameter: 014629
parameter: 014737
parameter: 014731
parameter: 014709
rule: 014579
parameter: 014750
parameter: 014703
units def: 630605
rule: 014615
parameter: 014726
parameter: 014791
parameter: 014685
parameter: 014675
units def: 630811
units def: 630461
parameter: 014717
parameter: 014711
units def: 630533
parameter: 014713
units def: 630497
parameter: 014643
rule: 014621
rule: 014555
rule: 014613
parameter: 014782
volume units: volume
units def: 630400
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parameter: 014653
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units def: 630763
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length unit: 027038
units def: 630581
parameter: 014776
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area units: area
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parameter: 014715
parameter: 014800
parameter: 014645
parameter: 014647
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units def: 630713
parameter: 014687
parameter: 014771
parameter: 014693
parameter: 014695

014701
constant: true
units: 630763
value: 2000.0
name: kIPR
type: Parameter

014748
constant: false
units: dimensionless
value: NaN
name: lambda_ER_S1
type: Parameter

014695
constant: false
units: 630811
value: NaN
name: JS1S2
type: Parameter

630847
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

630569
exponent: 1.0
scale: -12
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

630497
unit: 630521
unit: 630509
name: per_micromolar2
type: SBMLUnitsDef

014653
constant: true
units: 630605
value: 420.0
name: gPM
type: Parameter

630799
exponent: -2.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

014675
constant: true
units: 630497
value: 2.31E-5
name: A6
type: Parameter

630436
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

014624
constant: false
units: 630400
value: -70.1
name: Vm
type: Parameter

014800
constant: true
units: dimensionless
value: 20.0
name: gamma_ER
type: Parameter

014685
constant: true
units: 630424
value: 10.0
name: KINH
type: Parameter

014754
constant: false
units: dimensionless
value: NaN
name: lambda_ER_S2
type: Parameter

014629
constant: false
units: 630581
value: NaN
name: I_iNa
type: Parameter

630713
unit: 630751
unit: 630739
unit: 630726
name: attojoule_per_zeptomole_kelvin
type: SBMLUnitsDef

630533
unit: 630545
name: picofarad
type: SBMLUnitsDef

014687
constant: true
units: dimensionless
value: 4.0
name: hINH
type: Parameter

014655
constant: true
units: 630424
value: 1.0
name: KPM
type: Parameter

014737
constant: true
units: 630424
value: 2.0
name: K_beta
type: Parameter

014649
constant: false
units: 630557
value: NaN
name: gNSCC_Na
type: Parameter

014788
constant: true
units: 630629
value: 26.0
name: delta_s
type: Parameter

014635
constant: true
units: 630557
value: 0.01
name: gCa
type: Parameter

014707
constant: true
units: 630763
value: 4.0
name: k2
type: Parameter

014717
constant: true
units: 630424
value: 300.0
name: R3
type: Parameter

014774
constant: true
units: 630713
value: 0.008314
name: R
type: Parameter

014771
constant: false
units: 630424
value: 10100.0
name: NS1
type: Parameter

014809
constant: true
units: dimensionless
value: 3.0
name: hNSCC
type: Parameter

014689
constant: false
units: 630811
value: NaN
name: JNCX
type: Parameter

630763
unit: 630775
name: first_order_rate_constant
type: SBMLUnitsDef

014693
constant: true
units: 630424
value: 0.3
name: KNCX
type: Parameter

630726
exponent: 1.0
scale: -18
multipler: 1.0
kind: JOULE
type: SBMLUnit

630665
exponent: -1.0
scale: 0
multipler: 1.0
kind: COULOMB
type: SBMLUnit

014769
constant: true
units: 630424
value: 100.0
name: Bm
type: Parameter

630629
unit: 630665
unit: 630653
unit: 630641
name: micromolar_coulomb
type: SBMLUnitsDef

014554
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

014673
constant: true
units: 630461
value: 2.7E-5
name: A5
type: Parameter

630787
unit: 630799
name: per_second_squared
type: SBMLUnitsDef

014641
constant: true
units: 630557
value: 0.12
name: gNSCC_Ca_
type: Parameter

014669
constant: true
units: dimensionless
value: 6.0E-4
name: A2
type: Parameter

014726
constant: false
units: 630763
value: 0.306
name: phi3
type: Parameter

014791
constant: true
units: dimensionless
value: 100.0
name: gamma_S1
type: Parameter