661392
constant: true
units: 500451
value: -578.317
name: delta_S_gamma_gamma
type: Parameter

661272
constant: true
units: dimensionless
value: 2.5218
name: a
type: Parameter

661362
constant: true
units: 500415
value: 121900.0
name: delta_H_v
type: Parameter

661238
constant: false
units: dimensionless
value: NaN
name: i_Na
type: Parameter

500608
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scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

661248
constant: false
units: dimensionless
value: 0.0
name: O2
type: Parameter

661382
constant: true
units: 500451
value: 529.952
name: delta_S_gamma
type: Parameter

661372
constant: true
units: 500451
value: 0.00711
name: delta_S_cf
type: Parameter

661286
constant: false
units: 500499
value: NaN
name: eta
type: Parameter

661332
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value: 1.5717
name: z_eta
type: Parameter

661322
constant: true
value: 0.0
name: z_of
type: Parameter

661292
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units: 500499
value: NaN
name: epsilon
type: Parameter

500379
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661268
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units: dimensionless
value: 0.0
name: C4I
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661300
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units: 500499
value: NaN
name: delta_delta
type: Parameter

661258
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units: dimensionless
value: 0.0
name: C4
type: Parameter

661308
constant: true
units: 500523
value: 1.3806504E-23
name: k
type: Parameter

661314
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value: -0.9701
name: z_beta
type: Parameter

500620
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unit: 500632
name: C_mol
type: SBMLUnitsDef

661250
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units: dimensionless
value: 1.0
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kind: VOLT
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661342
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units: 500415
value: 263870.0
name: delta_H_beta
type: Parameter

661352
constant: true
units: 500415
value: 150333.0
name: delta_H_eta
type: Parameter

661240
constant: true
units: 661236
value: 0.044675
name: E_Na
type: Parameter

500560
unit: 500572
name: K
type: SBMLUnitsDef

661260
constant: false
units: dimensionless
value: 0.0
name: C0I
type: Parameter

661290
constant: false
units: 500499
value: NaN
name: delta
type: Parameter

500499
unit: 500511
name: first_order_rate_constant
type: SBMLUnitsDef

661236
constant: true
units: 500367
value: -0.12
name: V
type: Parameter

661348
constant: true
units: 500415
value: 79035.0
name: delta_H_of
type: Parameter

500668
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scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

661394
constant: true
units: 500451
value: -130.639
name: delta_S_delta_delta
type: Parameter

661274
constant: false
units: 500499
value: NaN
name: alpha
type: Parameter

661360
constant: true
units: 500415
value: 123020.0
name: delta_H_omega
type: Parameter

661380
constant: true
units: 500451
value: 338.915
name: delta_S_eta
type: Parameter

661374
constant: true
units: 500451
value: 786.217
name: delta_S_cn
type: Parameter

661284
constant: false
units: 500499
value: NaN
name: on
type: Parameter

661334
constant: true
value: -1.3281
name: z_v
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661388
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units: 500451
value: 225.175
name: delta_S_omega
type: Parameter

MODEL0848062679
substance units: 469466
compartment: 661177
units def: 500560
parameter: 661276
parameter: 661296
rule: 661223
rule: 661183
parameter: 661322
parameter: 661304
rule: 661209
parameter: 661378
parameter: 661268
notes: This a model from the article: Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation. Irvine LA, Jafri MS, Winslow RL. Biophys J 1999 Apr;76(4):1868-85 10096885 , Abstract: A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Irvine LA, Jafri MS, Winslow RL. (1999) - version02 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you de…
parameter: 661286
parameter: 661314
time units: 500656
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length unit: 222721
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units def: 500451
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parameter: 661382
parameter: 661306
parameter: 661236
parameter: 661328
rule: 661229
parameter: 661252
rule: 661235
parameter: 661270
is described by: http://identifiers.org/pubmed/10096885
units def: 500499
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area units: area
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units def: 500523
name: Irvine1999_CardiacSodiumChannel
rule: 661227
rule: 661187
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parameter: 661386
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units def: 500391
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volume units: volume
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curated: false
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661320
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661294
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661302
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units: 500451
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name: R
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661256
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661242
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661354
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unit: 500439
unit: 500427
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661340
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name: delta_H_alpha
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500355
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500427
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kind: JOULE
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units: 500415
value: 127970.0
name: delta_H_delta
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661366
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661376
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661346
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units: 500415
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name: delta_H_cn
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661296
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661276
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units: 500499
value: NaN
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661326
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500487
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661336
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name: z_cn
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661177
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units: litre
size: 1.0
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type: Compartment

500656
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name: time
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661386
constant: true
units: 500451
value: 70.078
name: delta_S_epsilon
type: Parameter

661310
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units: 500584
value: 6.62607095E-31
name: h
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500451
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unit: 500463
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661264
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units: dimensionless
value: 0.0
name: C2I
type: Parameter

661254
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units: dimensionless
value: 0.0
name: C2
type: Parameter

661318
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value: -1.3266
name: z_delta
type: Parameter

500584
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unit: 500596
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type: SBMLUnitsDef

661244
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units: dimensionless
value: NaN
name: P_open
type: Parameter

661304
constant: true
units: 500560
value: 286.0
name: T
type: Parameter

661364
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units: 500415
value: -99967.0
name: delta_H_gamma_gamma
type: Parameter

661280
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units: 500499
value: NaN
name: cn
type: Parameter

661358
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value: 79183.0
name: delta_H_epsilon
type: Parameter

500511
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661270
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661344
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value: 193.265
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661378
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value: 39.295
name: delta_S_on
type: Parameter

500644
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500475
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661278
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661324
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661370
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name: delta_S_beta
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661384
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units: 500451
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661298
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661338
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661288
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661330
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661306
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value: 96500.0
name: F
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500596
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661252
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value: 0.0
name: C1
type: Parameter

500463
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661266
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units: dimensionless
value: 0.0
name: C3I
type: Parameter

661316
constant: true
value: 1.5703
name: z_gamma
type: Parameter

661246
constant: false
units: dimensionless
value: 0.0
name: O1
type: Parameter

661350
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name: delta_H_on
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