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creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
is described by: http://identifiers.org/pubmed/19025648
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name: Kervizic2008_Cholesterol_SREBP
notes: Model of cholesterol regulation (with Boolean Formulae) (2008) This model is described in Dynamical modeling of the cholesterol regulatory pathway with Boolean networks ; Gwenael Kervizic and Laurent Corcos, BMC Systems Biology 2008, 2:99 doi: 10.1186/1752-0509-2-99 Abstract: Background: Qualitative dynamics of small gene regulatory networks have been studied in quite some details both with synchronous and asynchronous analysis. However, both methods have their drawbacks: synchronous analysis leads to spurious attractors and asynchronous analysis lacks computational efficiency, which is a problem to simulate large networks. We addressed this question through the analysis of a major biosynthesis pathway. Indeed the cholesterol synthesis pathway plays a pivotal role in dislypidemia and, ultimately, in cancer through intermediates such as mevalonate, farnesyl pyrophosphate and geranyl geranyl pyrophosphate, but no dynamic model of this pathway has been proposed until now. Results: We set up a computational framework to dynamically analyze large biological networks. This framework associates a classical and computationally efficient synchronous Boolean analysis with a newly introduced method based on Markov chains, which identifies spurious cycles among the results of the synchronous simulation. Based on this method, we present here the results of the analysis of the cholesterol biosynthesis pathway and its physiological regulation by the Sterol Response Element Binding Proteins (SREBPs), as well as the modeling of the action of statins, inhibitor drugs, on this pathway. The in silico experiments show the blockade of the cholesterol endogenous synthesis by statins and its regulation by SREPBs, in full agreement with the known biochemical features of the pathway. Conclusion: We believe that the method described here to identify spurious cycles opens new routes to compute large and biologically relevant models, thanks to the computational efficiency of synchronous simulat…
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orgname: EMBL-EBI

ORG:
  orgname: University of Brest
n:
  given: Gwenael
  family: Kervizic

W3 CDTF: Thu Feb 26 18:06:25 GMT 2009

ORG:
  orgname: University of Brest
n:
  given: Gwenael
  family: Kervizic

given: Gwenael
family: Kervizic

W3 CDTF: Thu Feb 26 18:06:25 GMT 2009

n:
  given: Lukas
  family: Endler

ORG:
  orgname: University of Brest

orgname: EMBL-EBI

given: Lukas
family: Endler

W3 CDTF: Thu Feb 26 18:06:25 GMT 2009

W3 CDTF: Tue Dec 02 10:58:47 GMT 2008