sucrose hydrolyzing enxyme, extracellular
Nicotinamide adenine dinucleotide - reduced
SUBSYSTEM: Purine and Pyrimidine Biosynthesis
Nicotinamide adenine dinucleotide phosphate - reduced
Nicotinamide adenine dinucleotide phosphate
hydrogen peroxide reductase (thioredoxin)
Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
tetrahydrofolate aminomethyltransferase, mitochondrial
hydrogen peroxide reductase (thioredoxin), mitochondrial
hydrogen peroxide reductase (thioredoxin), peroxisomal
Dolichyl-phosphate-mannose--protein mannosyltransferase, endoplasmic reticular
thymidine transport in via proton symport
(R)-Lactate:ferricytochrome-c 2-oxidoreductase
Thiamine diphosphate transport, mitochondria
SUBSYSTEM: Threonine and Lysine Metabolism
Thiamine transport in via proton symport
3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
SUBSYSTEM: Tyrosine, Tryptophan, and Phenylalanine Metabolism
Ceramide-1 synthase (26C), endoplasmic reticular
Ceramide-1 synthase (24C), endoplasmic reticular
Ceramide-2 synthase (26C), endoplasmic reticular
Ceramide-2 synthase (24C), endoplasmic reticular
Glycolipid 1,3-alpha-D-mannosyltransferase, Golgi apparatus
xylitol dehydrogenase (D-xyulose-forming)
glycero-3-phosphocholine transport (extracellular to cytosol)
glycerol-3-phosphate dehydrogenase (NAD)
glycerol-3-phosphate dehydrogenase (NAD), mitochondrial
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
glycero-3-phospho-1-inositol transport (extracellular to cytosol)
xanthosine transport in via proton symport
succinate-fumarate transport, mitochondrial
succinate dehydrogenase (ubiquinone-6), mitochondrial
SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
cytosine transport in via proton symport
Valine mitochondrial transport via proton symport
formate-tetrahydrofolate ligase, mitochondrial
5-Formyltetrahydrofolate:10-Formyltetrahydrofolate isomerase
5-formethyltetrahydrofolate cyclo-ligase, mitochondrial
D-fructose transport in via proton symport
5-formethyltetrahydrofolate cyclo-ligase
SUBSYSTEM: Fructose and Mannose Metabolism
Reduced glutathione via ABC system (vacuolar)
SUBSYSTEM: Starch and Sucrose Metabolism
guanosine transport in via proton symport
guanosine mitochondrial transport via proton symport
farnesyl diphosphate transport (mitochondrial)
glycine mitochondrial transport via proton symport
N-acteylglutamate synthase, mitochondrial
SUBSYSTEM: Arginine and Proline Metabolism
4-aminobutyrate transport in via proton symport
Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
Aminobutyraldehyde dehydrogenase, mitochondrial
hydroxyacylglutathione hydrolase, mitochondrial
1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
Methionyl-tRNA formyltransferase, mitochondrial
1D-myo-Inositol 1,4,5,6-tetrakisphosphate
SUBSYSTEM: Porphyrin and Chlorophyll Metabolism
formate dehydrogenase, cytosolic/mitochondrial
phosphoribosylaminoimidazolecarboxamide formyltransferase
aldehyde dehydrogenase (2-methylbutanol, NAD)
acid phosphatase, extracellular (secreted)
Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase
fatty acid synthase (n-C8:0), lumped reaction
D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
fatty acid synthase (n-C24:0), lumped reaction
aldehyde dehydrogenase (2-methylbutanol, NADP)
fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fatty acyl-ACP synthase (n-C8:0ACP), mitochondrial, lumped reaction
aldehyde dehydrogenase (isobutyl alcohol, NAD)
aldehyde dehydrogenase (isobutyl alcohol, NADP)
aldehyde dehydrogenase (isoamyl alcohol, NAD)
fatty-acyl-ACP synthase (n-C16:1ACP), mitochondrial
fatty-acyl-ACP synthase (n-C18:0ACP), mitochondrial
fatty-acyl-ACP synthase (n-C18:1ACP), mitochondrial
fatty-acyl-ACP synthase (n-C18:2ACP), mitochondrial
dihydroxyacetone phosphate transport, mitochondrial
ribonucleoside-diphosphate reductase (CDP), nuclear
L-glutamine transport out via proton symport, vacuolar
ribonucleoside-diphosphate reductase (CDP)
fatty-acyl-ACP synthase (n-C14:0ACP), mitochondrial
L-glutamine transport in via proton antiport (vacuolar)
ribonucleoside-diphosphate reductase (UDP), nuclear
fatty-acyl-ACP synthase (n-C14:1ACP), mitochondrial
Dihydropteroate mitochondrial transport via diffusion
ribonucleoside-diphosphate reductase (UDP)
S-adenosyl-L-methionine transport in via proton symport
ribonucleoside-diphosphate reductase (GDP), nuclear
deoxyinosine transport in via proton symport
S-Adenosyl-L-methionine transport, mitochondrial
fatty-acyl-ACP synthase (n-C12:0ACP), mitochondrial
Glycogen vacuolar 'transport' via autophagy
2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
ribonucleoside-triphosphate reductase (UTP)
ribonucleoside-triphosphate reductase (ATP)
ribonucleoside-triphosphate reductase (CTP)
L-glutamine transport via proton symport
glutamine nuclear transport via proton symport
ribonucleoside-triphosphate reductase (GTP)
aldehyde dehydrogenase (tryptophol, NAD)
panthetheine-phosphate adenylyltransferase
SUBSYSTEM: Pantothenate and CoA Biosynthesis
pantetheine-phosphate adenylyltransferase
putrescine excretion (cytosol to extracellular)
putrescine transport in via proton antiport
aldehyde dehydrogenase (2-phenylethanol, NAD)
urea transport via proton symport (2 H+)
L-hydroxyproline dehydrogenase (NAD), mitochondrial
aldehyde dehydrogenase (2-phenylethanol, NADP)
glycylpeptide N-tetradecanoyltransferase
D-mannose transport in via proton symport
Hydroxymethylglutaryl CoA synthase, mitochondrial
Hydroxymethylglutaryl-CoA mitochondrial transport
fatty-acyl-ACP synthase (n-C16:0ACP), mitochondrial
aldehyde dehydrogenase (isoamyl alcohol, NADP)
methionyl-tRNA synthetase, mitochondrial
methionine mitochondrial transport via proton symport
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, mitochondrial
Dihydroneopterin monophosphate dephosphorylase
fatty acid oxidation (tetradecansoyl-CoA), peroxisomal
SUBSYSTEM: Transport, Endoplasmic Reticular
dolichol phosphate endoplasmic reticular transport via proton symport
sphingoid base-phosphate phosphatase (sphinganine 1-phosphatase), endoplasmic reticulum
Dolichyl-phosphate D-mannosyltransferase
S-adenosyl-methionine delta-24-sterol-c-methyltransferase
saccharopine dehydrogenase (NAD, L-lysine forming)
Dihydroneopterin triphosphate pyrophosphatase
saccharopine dehydrogenase (NADP, L-glutamate forming)
N-acetylputrescine: oxygen oxireductase (deaminating)
acyl-CoA oxidase (hexacanoyl-CoA), peroxisomal
acyl-CoA oxidase (octadecanoyl-CoA), peroxisomal
acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
acyl-CpA oxidase (tetradecanoyl-CoA), peroxisomal
SUBSYSTEM: Glycine and Serine Metabolism
glycine hydroxymethyltransferase,, mitochondrial
acyl-CoA oxidase (dodecanoyl-CoA), peroxisomal
cholestenol delta-isomerase, lumped reaction
L-sorbitol dehydrogenase (L-sorbose-producing)
fatty-acyl-ACP synthase (n-C10:0ACP), mitochondrial
D-sorbitol dehydrogenase (D-fructose producing)
glutamine-fructose-6-phosphate transaminase
sphingoid base-phosphate phosphatase (phytosphingosine 1-phosphate), endoplasmic reticulum
fatty acid oxidation (octanoyl-CoA), peroxisomal
L-histidine transport via proton symport
2-methylcitrate dehydratase, mitochondrial
L-histidine transport in via proton antiport (vacuolar)
aldehyde dehydrogenase (3-aminopropanal, NAD)
aldehyde dehydrogenase (acetylaldehyde, NADP), mitochondrial
histidine mitochondrial transport via proton symport
aldehyde dehydrogenase (phenylacetaldehyde, NAD)
AMP transport via diffusion (cytosol to nucleus)
aldehyde dehydrogenase (indole-3-acetaldehyde, NADP), mitochondrial
Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
L-lysine transport in via proton antiport (vacuolar)
alcohol dehydrogenase, reverse rxn (acetaldehyde -> ethanol)
Malonyl-CoA-ACP transacylase, mitochondrial
2-dehydropantoate 2-reductase, mitochondrial
cytochrome P450 lanosterol 14-alpha-demethylase (NAD)
L-2-amino-3-oxobutanoate decarboxylation (spontaneous)
L-leucine transport out via proton symport, vacuolar
5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
arginine mitochondrial transport via proton symport
L-sorbitol transport via passive diffusion
D-sorbitol transport via passive diffusion
L-arginine transport in via proton antiport (vacuolar)
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase
UDPglucose--hexose-1-phosphate uridylyltransferase
fatty-acid--CoA ligase (n-C24:0), peroxisomal
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (nadph)
UDPgalactose transport (Golgi apparatus)
fatty-acid--CoA ligase (octanoate), peroxisomal
serine mitochondrial transport via proton symport
fatty-acid--CoA ligase (n-C26:0), peroxisomal
L-tyrosine transport out via proton symport, vacuolar
methenyltetrahydrifikate cyclohydrolase, mitochondrial
L-tyrosine transport in via proton antiport (vacuolar)
methylenetetrahydrofolate dehydrogenase (NAD)
methylenetetrahydrofolate dehydrogenase (NADP)
L-glutamate transport into mitochondria via hydroxide ion antiport
tyrosine mitochondrial transport via proton symport
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
L-glutamate transport via proton symport
tyrosine peroxisomal transport via proton symport
Glutamate transport (uniporter), mitochondrial
L-glutamate transport out via proton symport, vacuolar
inositol hexakisphosphate nuclear transport (diffusion)
L-asparagine transport out via proton symport, vacuolar
3-methyl-2-oxobutanoate hydroxymethyltransferase
L-aspartate transport via proton symport
UTP-glucose-1-phosphate uridylyltransferase
inositol-1,4,5-trisphosphate 3-kinase, nucleus
1D-myo-Inositol 1,4,5-trisphosphate nuclear transport via diffusion
all-trans-hexaprenyl diphosphate transport, mitochondrial
deoxyhypusine synthase, cytosolic/mitochondrial
L-erythro-4-hydroxyglutamate mitochondrial transport via diffusion
L-erythro-4-hydroxyglutamate peroxisomal transport via diffusion
D-galactose transport in via proton symport
asparagine synthase (glutamine-hydrolysing)
SUBSYSTEM: Alanine and Aspartate Metabolism
L-asparagine transport via proton symport
Hexadecanoate (n-C16:0) transport in via uniport
hexadecenoate (n-C16:1) transport in via uniport
deoxyuridine transport in via proton symport
sphingolipid long chain base kinase (sphinganine)
O-succinylhomoserine lyase (elimination)
L-asparagine transport in via proton antiport (vacuolar)
asparagine mitochondrial transport via proton transport
fatty-acid--CoA ligase (tetradecanoate), peroxisomal
3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA), peroxisomal
asparaginyl-tRNA synthetase, miotchondrial
fatty-acid--CoA ligase (dodecanoate), peroxisomal
sulfite transport (efflux, cytosol to extracellular)
3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA), peroxisomal
3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA), peroxisomal
D-erythrose 4-phosphate mtiochondrial transport via diffusion
3-hydroxyacyl-CoA dehydratase (3-hydroxyhexacosyl-CoA), peroxisomal
sphingolipid long chain base kinase (phytosphingosine)
fatty-acid--CoA ligase (hexadecanoate), peroxisomal
inositol-1,4,5-triphosphate 6-kinase, nucleus
glutamine phosphoribosyldiphosphate amidotransferase
uroporphyrinogen decarboxylase (uroporphyrinogen III)
fatty-acid--CoA ligase (tetradecenoate), peroxisomal
Homocysteine peroxisomal transport via proton symport
2-keto-4-methylthiobutyrate transamination
fatty-acid--CoA ligase (hexadecenoate), peroxisomal
P1-(5'-adenosyl),P4-(5'-guanosyl) tetraphosphate
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
glutamate nuclear transport via proton symport
inositol-1,3,4,5,6-pentakisphosphate 2-kinase, nuclear
Hydroxybenzoate octaprenyltransferase, mitochondrial
bicarbonate nuclear transport via diffusion
L-methionine transport via proton symport
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, peroxisomal
alkaline ceramidase (ceramide-2), endoplasmic reticulum
3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA), peroxisomal
L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase
inositol-1,3,4,5-triphosphate 6-kinase, nucleus
carbamoyl-phosphate synthase (glutamine-hydrolysing)
inositol-1,4,5,6- tetrakisphosphate 3-kinase, nucleus
Ferrocytochrome-c:hydrogen-peroxide oxidoreductase
3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA), peroxisomal
purine-nucleoside phosphorylase (Adenosine), mitochondrial
purine-nucleoside phosphorylase (Deoxyadenosine)
purine-nucleoside phosphorylase (Guanosine)
phosphopantothenoylcysteine decarboxylase
purine-nucleoside phosphorylase (Guanosine), mitochondrial
alpha,alpha-trehalose-phosphate synthase (UDP-forming)
purine-nucleoside phosphorylase (Adenosine)
trehalose transport in via proton symporter
UDP-glucose:ergosterol glucosyltransferase
trehalose vacuolar transport via proton symport
L-glutamate 5-semialdehyde dehydratase,, mitochondrial
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
tryptophan synthase (indoleglycerol phosphate)
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
Ergosta-5,6,22,24,(28)-tetraen-3beta-ol endoplamic reticular transport
glucose 6-phosphate endoplasmic reticular transport via diffusion
ergosterol endoplasmic reticular transport
ethanolamine transport via diffusion (extracellular)
ethanol transport to mitochondria (diffusion)
Ubiquinol:ferricytochrome-c oxidoreductase
Pantothenate transport via proton symport
Tryptophanyl-tRNA synthetase, mitochondrial
ribonucleoside-diphosphate reductase, nuclear
tryptophan mitochondrial transport via proton symport
ribonucleoside-diphosphate reductase (ADP)
trans-pentaprenyltranstransferase, mitochondrial
E-3-carboxyl-2-pentenedioate 5-methyl ester
protoporphyrinogen oxidase, mitochondrial
protoporphyrinogen IX mitochondrial transport
L-tryptophan transport via proton symport
indole-3-acetate mitochondrial transport via diffusion
Isoleucine transport from mitochondria to cytosol
L-isoleucine transport in via proton antiport (vacuolar)
L-isoleucine transport out via proton symport, vacuolar
cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)
fatty acid peroxisomal transport via ABC system
L-isoleucine transport via proton symport
isoleucyl-tRNA synthetase, mitochondrial
N4-Acetylaminobutanal:NAD+ oxidoreductase
5-methylthioribose-1-phosphate isomerase
ribonucleoside-diphosphate reductase (GDP)
5,10-methylenetetrahydrofolatereductase (NADPH)
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
purine-nucleoside phosphorylase (Xanthosine)
cytidine transport in via proton symport
purine-nucleoside phosphorylase (Deoxyinosine)
NADH dehydrogenase, cytosolic/mitochondrial
purine-nucleoside phosphorylase (Inosine)
purine-nucleoside phosphorylase (Deoxyguanosine)
pyruvate transport in via proton symport
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
glycine-cleavage complex (lipoamide), mitochondrial
pyruvate mitochondrial transport via proton symport
glycine-cleavage system (lipoamide), mitochondrial
pyruvate peroxisomal transport via proton symport
citrate/isocitrate antiport into peroxisome
thiazole phosphate synthesis (ribose 5-phosphate), yeast-specifc
Indoleacetaldehyde transport (extracellular)
threonine mitochondrial transport via proton symport
indole-3-acetaldehyde mitochondrial transport via diffusion
L-threonine transport via proton symport
glycine-cleavage complex (lipoylprotein), mitochondrial
pyruvate decarboxylase (acetoin-forming)
thiazole phosphate synthesis (xylulose 5-phosphate), yeast-specific
isobutyl alcohol transport (extracellular)
Isobutyl acetate transport (extracellular)
cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)
inositol transport in via proton symport
isobutyl alcohol transport (mitochondrial)
(S)-Lactate:ferricytochrome-c 2-oxidoreductase
fatty acyl-CoA peroxisomal transport via ABC system
D1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
pyrimidine-nucleoside phosphorylase (uracil)
CO2 transport (diffusion), mitochondrial
phosphoribosylaminoimidazolesuccinocarboxamide synthase
phosphoribosylformylglycinamidine synthase
ribose transport in via proton symporter
1-alpha-D-Galactosyl-myo-inositol galactohydrolase
riboflavin transport in via proton symport
L-phenylalanine transport via proton symport
reduced thioredoxin peroxisomal transport via diffusion
phosphoribosylglycinamide formyltransferase
oxidized thioredoxin peroxisomal transport via diffusion
glyceraldehyde-3-phosphate dehydrogenase
isoamyl alcohol transport (extracellular)
isoamyl alcohol transport (mitochondrial)
galactose-1-phosphate uridylyltransferase
D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate
L-hydroxyproline dehydrogenase (NADP), mitochondrial
hypoxanthine phosphoribosyltransferase (Hypoxanthine)
fatty-acid--CoA ligase (decanoate), peroxisomal
hypoxanthine transport via proton symport
3-phosphoshikimate 1-carboxyvinyltransferase
carnitine-acetylcarnitine carrier, peroxisomal
carnithine-acetylcarnithine carrier, mitochondrial
coproporphyrinogen oxidase (O2 required)
Isoamyl acetate transport (extracellular)
carnitine O-aceyltransferase, mitochondrial
carnitine O-acetyltransferase, reverse direction, peroxisomal
L-carnitine transport out of mitochondria via diffusion
phytosphinganine 1-phosphate endoplasmic reticular transport
ceramide-1 (C24) endoplasmic reticular transport
ceramide-1 (C26) endoplasmic reticular transport
YGL205W, YIL160C, YKR009C, YNL202W, YOR180C
ceramide-2 (C24) endoplasmic reticular transport
aldehyde dehydrogenase (tryptophol, NAD), mitochondrial
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
alcohol dehydrogenase, reverse rxn (acetaldehyde -> ethanol), mitochondrial
aldehyde dehydrogenase (indole-3-acetaldehyde, NAD), mitochondrial
L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
aldehyde dehydrogenase (indole-3-acetaldehyde, NADP)
L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
Phenethyl acetate transport (extracellular)
alkaline ceramidase (ceramide-1), endoplasmic reticulum
ceramide-2 (C26) endoplasmic reticular transport
YBR127C, YDL185W, YEL027W, YEL051W, YGR020C, YHR026W, YHR039C-A, YKL080W, YLR447C, YOR270C, YOR332W, YPL234C, YPR036W
C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
C-4 sterol methyl oxidase (4-methylzymosterol)
Oleoyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
pyruvate dehydrogenase (dihydrolipoamide dehydrogenase)
3',5'-cyclic-nucleotide phosphodiesterase
aldehyde dehydrogenase (isobutyl alcohol, NAD), mitochondrial
dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate), mitochondrial
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
deoxyguanosine transport in via proton symport
dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate), mitochondrial
2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
all-trans-Pentaprenyl diphosphate transport, mitochondrial
aldehyde dehydrogenase (isoamyl alcohol, NAD), mitochondrial
This is a reconstruction of the biochemical network of the yeast Saccharomyces cerevisiae carried out at a jamboree organized in April 2007 in the Manchester Centre for Integrative Systems Biology. It is the result of a consensus merger of two previous reconstructions. Technical notes: The compartments included here have no volume defined; there are no reliable estimates available for those volumes yet. There are no kinetic functions defined for the reactions because this model only represents the chemical structure of the network (stoichiometry). All reactions are marked reversible because all chemical reactions are reversible. The model is described in the article and available as supplementary material: A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Herrgård MJ, Swainston N et al. , Nat Biotechnol. 2008 Oct;26(10):1155-60. PMID: 18846089 , doi: 10.1038/nbt1492 Abstract: Genomic data allow the large-scale manual or semi-automated assembly of metabolic network reconstructions, which provide highly curated organism-specific knowledge bases. Although several genome-scale network reconstructions describe Saccharomyces cerevisiae metabolism, they differ in scope and content, and use different terminologies to describe the same chemical entities. This makes comparisons between them difficult and underscores the desirability of a consolidated metabolic network that collects and formalizes the 'community knowledge' of yeast metabolism. We describe how we have produced a consensus metabolic network reconstruction for S. cerevisiae. In drafting it, we placed special emphasis on referencing molecules to persistent databases or using database-independent forms, such as SMILES or InChI strings, as this permits their chemical structure to be represented unambiguously and in a manner that permits automated reasoning. The reconstruction is readily available via a publicly accessible database and in the Systems Biology Markup Language (http://www.comp-sys-bio.org/yeastnet). It can be maintained as a resource that serves as a common denominator for studying the systems biology of yeast. Similar strategies should benefit communities studying genome-scale metabolic networks of other organisms. Up to date versions can be found under http://www.comp-sys-bio.org/yeastnet/ This SBML representation of the yeast metabolic network is made available under the Creative Commons Attribution-Share Alike 3.0 Unported Licence (see www.creativecommons.org ). To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
nicotinate-nucleotide adenylyltransferase
aldehyde dehydrogenase (2-phenylethanol, NAD), mitochondrial
carbamoyl phosphate nuclear transport via diffusion
Isopentenyl diphosphate transport, mitochondrial
N-carbomoyl-L-aspartate transport, diffusion
YBR026C, YER061C, YHR067W, YKL055C, YKL192C, YOR221C
Itaconate--CoA ligase (ADP-forming), mitochondrial
2-isopropylmalate synthase, mitochondrial
Alcohol Acetyltransferase (isoamyl alcohol)
2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, mitochondrial
Myristicoyl-CoA desaturase (n-C14:0CoA -> n-C14:1CoA)
guanine mitochondrial transport via diffusion
deoxycytidine transport in via proton symport
3,4-Dihydroxy-2-butanone-4-phosphate synthase
orntithine transport in via proton symport
Alanine transport from mitochondia to cytoplasm
Alcohol Acetyltransferase (Phenylethanol alcohol)
aldehyde dehydrogenase (2-methylbutanol, NAD), mitochondrial
nucleoside-diphosphate kinase (ATP:dGDP)
2-oxoadipate and 2-oxoglutarate transport
nucleoside-diphosphate kinase (ATP:dTDP)
nucleoside-diphosphate kinase (ATP:dCDP)
GTP/GDP translocase, mitochondrial (electroneutral)
nucleoside-diphosphate kinase (ATP:dUDP)
Alcohol Acetyltransferase (isobutyl alcohol)
nucleoside-diphosphate kinase (ATP:dADP)
Alcohol Acetyltransferase (2-methylbutanol)
5-diphosphoinositol-1,2,3,4,6-pentakisphosphate diphosphohydrolase
5-diphosphoinositol-1,2,3,4,6-pentakisphosphate synthase
diphosphoinositol-1,3,4,6-tetrakisphosphate diphosphohydrolase
diphosphoinositol-1,3,4,6-tetrakisphosphate synthase
phosphate transport via hydroxide ion symport, mitochondrial
phosphoadenylyl-sulfate reductase (thioredoxin)
7,8-Diaminononanoate transport via proton symport
deoxyadenosine transport in via proton symport
3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA), peroxisomal
3-Hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA), peroxisomal
3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA), peroxisomal
D-lactate/pyruvate antiport, mitochondrial
ammonia transport (efflux, cytosol to extracellular)
N,N-bisformyl-dityrosine transport (extracellular)
2-oxoglutarate nuclear transport via proton symport
nicotinamide-nucleotide adenylyltransferase
YBR127C, YDL185W, YEL027W, YEL051W, YGR020C, YHR026W, YHR039C-A, YKL080W, YLR447C, YMR054W, YOR332W, YPL234C, YPR036W
oxoglutarate dehydrogenase (dihydrolipoamide S-succinyltransferase)
phosphoribosylaminoimidazole carboxylase
3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA), peroxisomal
phosphate vacuolar transport via proton symport
3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosyl-CoA), peroxisomal
phosphate nuclear transport via proton symport
phosphate peroxisomal transport via proton symport
YDR204W, YGL119W, YGR255C, YLR201C, YML110C, YOL096C, YOR125C
phenylalanyl-tRNA synthetase, mitochondrial
Phenylalanine mitochondrial transport via proton symport
cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)
Squalene epoxidase, endoplasmic reticular (NADP)
nicotinate-nucleotide adenylyltransferase, mitochondrial
Squalene epoxidase, endoplasmic reticular (NAD)
ornithine mitochondrial transport via proton antiport
NMN peroxisomal transport via proton symport
NMN mitochondrial transport via proton symport
succinate-semialdehyde dehydrogenase (NADP)
cytochrome P450 lanosterol 14-alpha-demethylase (NADP)
O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase
2-oxo-4-methyl-3-carboxypentanoate decarboxylation
Lysine mitochondrial transport via proton symport
L-aspartate nuclear transport via diffusion
L-aspartate transport out via proton symport, vacuolar
S-adenosyl-L-homocysteine transport, mitochondrial
4-amino-5-hydroxymethyl-2-methylpyrimidine synthetase
nicotinate-nucleotide diphosphorylase (carboxylating)
nicotinate-nucleotide diphosphorylase (carboxylating), mitochondrial
N-acetyl-g-glutamyl-phosphate reductase, mitochondrial
spermidine transport in via proton antiport
sphinganine 1-phosphate endoplasmic reticular transport
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
mannan endoplasmic reticulum transport via diffusion
panthetheine 4'-phosphate mitochondrial transport
Phenylacetaldehyde transport (extracellular)
Phenylacetaldehyde transport (mitochondrial)
adenosine transport in via proton symport
spermidine excretion (cytosol to extracellular)
aspartate mitochondrial transport via proton symport
aspartate nuclear transport via proton symport
Squalene-2,3-epoxide endoplamic reticular transport
2-aceto-2-hydroxybutanoate synthase, mitochondrial
ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate), mitochondrial
acetohydroxy acid isomeroreductase, mitochondrial
acyl-CoA oxidase (decanoyl-CoA), peroxisomal
C-s24 sterol reductase, endoplamic reticular
C-3 sterol dehydrogenase (4-methylzymosterol)
C-3 sterol keto reductase (4-methylzymosterol)
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
Adenosine 3',5'-bisphosphate mitochondrial transport
Octadecynoate (n-C18:2) transport in via uniport
acetyl-CoA acyltransferase (tetracosanoyl-CoA), peroxisomal
Octadecanoate (n-C18:0) transport in via uniport
L-cystine transport via proton symport (vacuolar)
Octadecenoate (n-C18:1) transport in via uniport
N-acetylglucosamine-6-phosphate synthase
O-acetylcarnintine transport into mitochondria via diffusion
acetylcarnitine transport out of peroxisome
acyl carrier protein synthase, mitochondrial
L-leucine transport in via proton antiport (vacuolar)
acteylornithine transaminase, mitochondrial
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
acetyl-CoA C-acetyltransferase, mitochondrial
acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
acetyl-CoA acyltransferase (hexadecanoyl-CoA), peroxisomal
acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
L-arabinitol transport via passive diffusion
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
8-Amino-7-oxononanoate transport via proton symport
6-phospho-D-glucono-1,5-lactone endoplasmic reticular transport via diffusion
2-Dehydro-3-deoxy-D-arabino-heptonate7-phohsphate mitochondrial transport via diffusion
2-Dehydropantoate mitochondrial transport
L-aminoadipate-semialdehyde dehydrogenase (NADH)
L-aminoadipate-semialdehyde dehydrogenase (NADPH)
2-hydroxybutyrate cotransport with proton
5-Aminolevulinate mitochondrial transport
5-Aminolevulinate transport in via proton symport
3-Octaprenyl-4-hydroxybenzoate mitochondrial transport
4-aminobutanal mitochondrial transport via diffusion
4-aminobutanoate mitochondrial transport via diffusion
4-Aminobenzoate mitochondrial transport via diffusion
4-Hydroxybenzoate mitochondrial transport
trans-4-hydroxy-L-proline mitochondrial transport via diffusion
L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
4-hydroxy-2-oxoglutarate mitochondrial transport via diffusion
4-hydroxy-2-oxoglutarate peroxisomal transport via diffusion
3-methylbutanal transport (extracellular)
3-methylbutanal transport (mitochondrial)
3-Hexaprenyl-4-hydroxy-5-methoxybenzoate decarboxylase, mitochondrial
3-Hexaprenyl-4,5-dihydroxybenzoate hydroxylase, mitochondrial
3-Methyl-2-oxopentanoate transport, diffusion, mitochondrial
3-methyl-2-oxobutanoate transport, diffusion, mitochondrial
2-oxoadipate transport out of mitochondria via diffusion
YBR221C, YER178W, YFL018C, YGR193C, YNL071W
2-phenylethanol transport, mitochondrial
3-(4-hydroxyphenyl)pyruvate mitochondrial transport via proton symport
4-Hydroxyphenylpyruvate:oxygen oxidoreductase
3-(4-hydroxyphenyl)pyruvate peroxisomal transport via proton symport
2-Isopropylmalate transport, diffusion, mitochondrial
3-Carboxy-4-methyl-2-oxopentanoate transport, diffusion, mitochondrial
S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase, mitochondrial
3-Hexaprenyl-4,5-dihydroxybenzoate transport, mitochondrial
YAL044C, YBR221C, YDR019C, YER178W, YMR189W
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, mitochondrial
2-Hexaprenyl-6-methoxyphenol monooxygenase, mitochondrial
hexaprenyldihydroxybenzoate methyltransferase
2-methyl-1-butanol transport (extracellular)
2-Methylbutanal transport (mitochondrial)
2-Methylbutanal transport (extracellular)
2-methylpropanal transport (extracellular)
2-methyl-1-butanol transport (mitochondrial)
2-methylpropanal transport (mitochondrial)
adenosylmethionine-8-amino-7-oxononanoate transaminase
5-Methylthio-5-deoxy-D-ribulose 1-phosphate
5-Methylthio-5-deoxy-D-ribose 1-phosphate
aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
aldehyde dehydrogenase (acetaldehyde, NADP)
YGL205W, YIL160C, YKR009C, YLR284C, YNL202W, YOR180C
YGL205W, YIL160C, YKR009C, YLR284C, YNL202W