COPASI54
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TBK1/IKKe
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_7e7b85da_e4b1_4793_b02e_cae25f54b627
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5761a4e6_794d_4fb1_b5eb_6dd466b75c0f
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d4ab6670_4a31_4002_901e_81dc8fba51bf
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5bcaca5c_63b4_4fe8_bf84_56a67b69e498
value: 0.001
name: k1
type: LocalParameter

COPASI68
type: Reaction
fast: false
reversible: false
name: TRIF11) IKK Phosphorylation by RIP1

http://identifiers.org/biomodels.db/BIOMD0000000489#e5b7be1f_1bfd_4a50_b5b7_e7d3c1bde205
stoichiometry: 1.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_6a4768d5_2a78_43bb_a2f7_1aab902c1df9
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

COPASI114
fast: false
reversible: false
name: NFkB39) IkBb:NFkB Nuclear Export
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#d32e7359_b55a_4f0c_a9a1_a5540b071de9
value: 0.1
name: k
type: LocalParameter

COPASI53
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: LPS:LBP:CD14:TLR4:RIP1:TRAM:TRIF:TBK/IKKe
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_1d6bc423_5e78_4eb6_b51d_4b332290e3b8
value: 2.8E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_7c95545d_a995_4a18_b037_010953af532e
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_0cd87f18_8de7_4a8f_a5a1_c3746523b576
value: 1.27E-7
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_56871999_1d23_41a6_ac1b_e268929a9970
stoichiometry: 1.0
species: COPASI48
type: SpeciesReference

COPASI67
reversible: true
type: Reaction
name: TRIF10) TNFa Receptor Complex Formation
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000489#d2580fea_44cd_453c_8f05_d192f1b38bd1
stoichiometry: 1.0
species: COPASI38
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_090ef087_36bf_4527_a597_2f0202714b55
stoichiometry: 1.0
species: COPASI39
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_72066df4_7395_4eaf_953c_b633ef2df662
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI113
fast: false
reversible: true
name: NFkB35) IkBe Nuclear Import/Export
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_07046c02_d57a_4e04_9e0b_d818037b3923
value: 0.0075
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_302a39f9_2e3c_4704_b3ae_cf1e44653886
value: 0.1
name: k2
type: LocalParameter

COPASI56
type: Reaction
name: MYD882) IRAK1 and TRAF6 Phosphorylation
fast: false
reversible: true

COPASI66
fast: false
reversible: false
name: TRIF09) TNFa Degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#cd946fd0_5bd3_4264_a9a9_65fcd439d003
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/BIOMD0000000489#_320eb0fd_b270_4519_83f1_f36bbf09c478
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_05c31760_a324_4016_9a13_70976d1185ed
stoichiometry: 1.0
species: COPASI11
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#ef83428e_1764_4b98_9b51_657152f495d2
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#c50fab8a_0224_431a_8a30_a6585b067c67
stoichiometry: 1.0
species: COPASI41
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_20be09c4_cba5_444c_b178_0852dc5fe93e
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

COPASI116
fast: false
reversible: false
name: NFkB41) IkBe:NFkB Nuclear Export
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_5dee16b6_0c3b_4ded_b93b_f3e7f26a751f
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d4e5ef2e_303a_4edc_8ea6_bfa821277518
stoichiometry: 1.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_639f0f35_6147_4860_a97b_d1b3d7b95692
stoichiometry: 1.0
species: COPASI50
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#bebf1737_113d_4fce_8d48_61a01f3d58b8
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

COPASI55
reversible: true
fast: false
name: MYD881) Receptor Complex Formation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#f60aa772_a323_4429_9c13_597fc842a41b
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI65
fast: false
reversible: false
name: TRIF06) Constitutive TNFa Synthesis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#fff898aa_26ad_4629_9730_58c3526b9201
stoichiometry: 1.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_83559907_1bbb_4294_aa90_d888e6a9f305
value: 0.001
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_739894bc_c820_47fd_96e3_a00344577e74
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000489#b8d96e78_2cf5_4e92_b5e9_02fab2e159e0
value: 1.54E-6
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_8e3c37e7_6c15_4639_9787_edc96c717064
value: 0.00407
name: k1
type: LocalParameter

COPASI115
reversible: true
name: NFkB40) IKK:IkBe:NFkB Binding (2)
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_6e1a51d8_6fd2_49ed_a230_91e053530417
value: 0.00408
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_4eb9da27_8de1_42dc_b85c_96df878390e7
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

COPASI58
type: Reaction
fast: false
reversible: false
name: MYD884) IKK Phosphorylation by TAK1

http://identifiers.org/biomodels.db/BIOMD0000000489#f0080b03_3f0e_4414_bf38_6fb425eea25d
stoichiometry: 1.0
species: COPASI51
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_6223008a_983b_4ab3_bf69_162cddbc15fa
value: 0.1
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_479e110a_a31c_4b1e_afa2_10fb76eff143
stoichiometry: 1.0
species: COPASI35
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_523aaf38_1443_4633_9c07_b3a3ff5fb303
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_2929c688_7282_41f1_bf39_cdfa0260d6d6
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_95779c10_5f3a_4f0a_8962_45661fbc8dfd
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

COPASI110
fast: false
reversible: false
name: NFkB30) IkBb Degradation
type: Reaction

COPASI78
fast: false
reversible: false
name: NFkB10) IkBa:NFkB Constitutive Degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_41e4e387_2195_4ec7_871c_6d263536f966
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_01bd307f_5de2_4482_8da8_906ae9e4c18d
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_37c6be7e_58a8_48d7_8318_cc37bb66c6e8
value: 0.0022
name: k1
type: LocalParameter

COPASI100
fast: false
reversible: false
name: TRIF06a)Inducible TNFa Synthesis by NFkB
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_7cce1a98_f2b2_44c4_adc3_b531c23eb80c
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#f10201cb_58d8_4c28_982b_675b93406e1d
value: 1.0E-4
name: k2
type: LocalParameter

COPASI57
name: MYD883) TAK/TAB Binds to TRAF6
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_4005f47f_7913_4878_9275_cbc946d43475
stoichiometry: 1.0
species: COPASI20
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#cf0072c5_4e77_49e8_968e_1f7c908a00d0
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_6c13babc_12da_4c08_92fd_1bac986c16b8
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_9b761136_b124_4750_8837_80b291abffa4
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI77
fast: false
reversible: false
name: NFkB09) IKK:IkBe:NFkB Catalysis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_9fd276fa_508b_49af_8e0a_12662c4fbfbd
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_674385fc_b7c8_45b3_9ab6_9be47d4bd0b3
stoichiometry: 1.0
species: COPASI39
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_2c4d9364_2b98_479c_b944_ad0ae3cd1eb0
stoichiometry: 1.0
species: COPASI46
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_77090a89_cdc3_49bc_af79_09761763980c
stoichiometry: 1.0
species: COPASI53
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_3bdc196e_c02a_413a_8dfb_5b8a6355e2ee
stoichiometry: 1.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#db31a2c8_d305_476c_b9de_92251c0d5a07
value: 1.13E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#ba2b603e_6d70_427c_821d_4de87f68ea5d
value: 0.1
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#f4149da6_8256_4852_aed0_f694b8b3fde9
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#fc416f06_b89d_4d25_b1b3_8e6af1562302
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#cddd973e_28ba_4cef_b99e_9334cc5cc59b
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_24f1d68d_5395_4804_b660_127b8b096d22
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#a6aae0d9_7cab_455b_91cc_f1dc91d66489
stoichiometry: 1.0
species: COPASI49
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5c9bf8ea_ec9f_4b2d_a13d_f390c72d9ade
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

COPASI112
fast: false
reversible: false
name: NFkB34) IkBe Degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_6d4a4e86_49c1_4764_88dd_2d1f39a38674
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#cedbe103_cefc_4292_be80_1b241fb22bd2
value: 3.0E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#d40ba9a3_0df6_4515_ade5_8511a21d364e
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5213780e_2fe0_4b31_8a45_ebc3a9395ad9
value: 0.185
name: k1
type: LocalParameter

COPASI59
fast: false
reversible: false
name: MYD885) IKK[P] Dephosphorylation
type: Reaction

COPASI69
type: Reaction
fast: false
name: NFkB01) IkBa:NFkB Binding
reversible: true

COPASI79
fast: false
reversible: false
name: NFkB12) IkBe:NFkB Constitutive Degradation
type: Reaction

COPASI111
fast: false
name: NFkB32) IKK:IkBe Binding
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_5091e6f6_9119_49a8_b982_f013e2ec4c98
value: 2.0E-4
name: k2
type: LocalParameter

COPASI89
fast: false
reversible: false
name: NFkB26) IkBa Degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#f73becad_ff63_4b74_8e07_179f0b08f11a
value: 1.13E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_51c5dd2f_5ae1_41c6_a678_3eace1e2c2f0
value: 0.02
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_078909e9_f386_48ad_8b97_4ab5d8162a7a
value: 0.00125
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#cb7ea75c_7e31_49d8_9837_a3e22eaafb4d
stoichiometry: 1.0
species: COPASI51
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_646e3115_776a_45ed_bc3f_c7ed4d54aaaa
stoichiometry: 1.0
species: COPASI41
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#a3900432_dba0_48aa_9df6_dedfe11c7020
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d7bd6e34_93bb_44ce_9501_74aca618a183
value: 0.00175
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_1013dd8f_b5fc_4a93_8b0f_d26012318174
value: 2.8E-4
name: k1
type: LocalParameter

COPASI5
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: LPS
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_69cc03e9_056f_4aa0_b84f_b9182ed6a8ef
value: 1.0E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_13445c7e_47e1_4475_8621_c88a807109d3
value: 0.0125
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#e0de9b39_7484_4789_a6c8_f6ebbdf91e41
stoichiometry: 1.0
species: COPASI46
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_0a52fe21_5721_43a2_9970_4a5efd189da4
value: 1.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#e1a9f382_e019_4cfe_a0a6_710e7a2a5d9d
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#f46ef277_7269_4365_87cd_022809c5a320
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#c8d30337_16a5_4dfa_8492_a79417a34b0e
value: 1.5E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_308b4cf9_83fa_4c5c_8bf2_25c7fe60ce53
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_1d7a3a24_c8c7_4f4a_8dab_83c3ec4a4b7d
stoichiometry: 1.0
species: COPASI47
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#ab149162_5993_4f96_8030_19fc63eb9537
stoichiometry: 1.0
species: COPASI49
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_2eaf65c9_e632_433f_9b0b_8f03968aa731
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

COPASI4
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: LBP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_349637b0_f345_4ac3_ab0a_d5ad6542bf91
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_334f5d66_3f83_4052_b0e7_75ae6de2979d
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_0276e3dd_f2c2_47a5_b01e_de81b0929bc5
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#ca0628d5_eff7_4266_891d_49bbf1186811
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_18ee1b3e_cdba_4b24_875c_d3c5ba7b2b1f
value: 0.003
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_03791d8a_5b03_43e9_9983_cb6e2ac77110
stoichiometry: 2.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_7c513ea2_73b7_4b30_b026_979f6a19c6d1
value: 0.1
name: k1
type: LocalParameter

COPASI7
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: MyD88
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#e298e12e_9192_4e9f_b4c9_60b223a70444
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_50909666_63bf_445c_9d07_48293eb103cb
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_67f72ccc_a198_4e97_b17d_270404aa643b
stoichiometry: 1.0
species: COPASI45
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_59c147bf_1ebd_412d_96fa_6ba783ab5395
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_6bbd7201_cd49_4886_881f_e4eb8ff2fe57
stoichiometry: 2.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_9570d9af_a298_4e55_ac78_4dd738d311b6
value: 0.0052
name: k1
type: LocalParameter

COPASI6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: LPS:LBP:CD14:TLR4:TIRAP:MyD88:IRAK4
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#c0d2608f_028f_4b89_8a79_bbaecc839cc0
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_45abf932_7dab_4259_9a34_a71e7db9f828
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#e723e1e7_471b_45d6_ad56_bcf8c5547d74
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_8bd91999_aff7_43a4_874c_a8128fda4638
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#e1aa746e_79ee_40d4_8764_fcc51a4b7f02
value: 0.00408
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_3eed03f1_ca5d_4e59_8a85_785628b11b72
stoichiometry: 1.0
species: COPASI43
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#bfb0f194_6f26_490d_8c29_9fcf5c5325df
stoichiometry: 1.0
species: COPASI38
type: SpeciesReference

COPASI109
fast: false
reversible: false
name: NFkB23) IkBe mRNA degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_1c53a6b6_3d77_4aa1_8bf7_0a048f122eb6
value: 1.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#fb36c103_2bc5_462e_8ebf_963c776fcd82
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_096db5c9_6102_44c3_ae63_fa3b5819d2d2
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

BIOMD0000000489
reaction: COPASI66
is: MODEL1303230000
species: COPASI29
reaction: COPASI99
reaction: COPASI107
reaction: COPASI117
is described by: http://identifiers.org/pubmed/23936158
time units: time
reaction: COPASI82
species: COPASI43
species: COPASI13
species: COPASI28
species: COPASI14
reaction: COPASI77
reaction: COPASI83
species: COPASI8
name: Modified Mass Action
species: COPASI9
curated: true
area units: area
species: COPASI42
reaction: COPASI100
reaction: COPASI62
species: COPASI37
species: COPASI23
species: COPASI38
reaction: COPASI110
reaction: COPASI116
reaction: COPASI67
reaction: COPASI113
length unit: length
function def: COPASI119
occurs in: http://identifiers.org/taxonomy/10090
function def: COPASI118
reaction: COPASI86
reaction: COPASI76
species: COPASI47
species: COPASI22
reaction: COPASI93
species: COPASI17
species: COPASI18
reaction: COPASI73
species: COPASI53
species: COPASI54
species: COPASI50
reaction: COPASI94
species: COPASI31
species: COPASI46
species: COPASI32
reaction: COPASI108
species: COPASI27
reaction: COPASI97
reaction: COPASI57
type: SBMLModel
reaction: COPASI63
reaction: COPASI111
reaction: COPASI70
reaction: COPASI80
species: COPASI41
reaction: COPASI78
reaction: COPASI84
species: COPASI11
species: COPASI26
species: COPASI12
reaction: COPASI90
reaction: COPASI87
is version of: GO:0008588
species: COPASI6
species: COPASI2
species: COPASI7
species: COPASI3
reaction: COPASI58
species: COPASI35
is derived from: http://identifiers.org/pubmed/16166516
species: COPASI21
species: COPASI36
reaction: COPASI68
reaction: COPASI114
reaction: COPASI95
reaction: COPASI55

http://identifiers.org/biomodels.db/BIOMD0000000489#_8fab984a_2fba_461b_b30f_45e9cb4252f0
value: 0.0015
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#adadc692_1d25_4ed3_b4b9_177efed43eab
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_52706005_e657_43db_90f9_f839cb5387df
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

COPASI108
fast: false
reversible: false
name: NFkB22) Constitutive IkBe mRNA Synthesis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_5cbe925d_8d15_42ca_a843_e5bba3927ec0
value: 0.5
name: k1
type: LocalParameter

COPASI9
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TLR4
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_94f5399a_9d7c_457d_86e5_4b5deb2f02ba
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_6fda8cf9_f5b8_4295_8dee_6bf6ee43a132
stoichiometry: 1.0
species: COPASI26
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#b7f8c624_f8cf_4b89_b2d8_0c6bae7d35bd
stoichiometry: 1.0
species: COPASI43
type: SpeciesReference

COPASI107
fast: false
reversible: false
name: NFkB21) IkBb mRNA degradation
type: Reaction

COPASI8
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TIRAP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_077d56d0_9de2_4d81_a314_3088b105c61b
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

COPASI117
fast: false
reversible: false
name: NFkB43) IKK:IkBb Catalysis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_057ccc76_e75b_4545_9035_ee5fc0846e8a
stoichiometry: 1.0
species: COPASI49
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_480c7bec_6586_44c4_bf66_8d52db35d767
value: 1.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_3223d5e0_b9e9_4614_b12d_1ddc9228ab7b
value: 0.1
name: Km
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_456a96b7_f622_4b9b_9800_a33ec7af8a70
value: 0.1
name: Km
type: LocalParameter

COPASI40
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: NFkB(nuc)
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_5f803ea8_5da5_43e5_97a7_924ae2fddac8
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_4ce89227_14b1_4576_8c25_ac18b9707b51
stoichiometry: 1.0
species: COPASI19
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_019535ee_3f99_4fbc_a4fc_d012ab985d70
stoichiometry: 1.0
species: COPASI52
type: SpeciesReference

COPASI106
fast: false
reversible: true
name: NFkB16) Nuclear IkBe:NFkB Binding
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#a76fa617_f8b8_440f_9f23_303264fd1baa
stoichiometry: 2.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#aac367e9_5d57_437f_b29b_ae422eb1ec7b
value: 0.1
name: k
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_141e1437_120c_4825_a9db_cb6547b3e166
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_80ad0306_4663_4e02_a913_f13eeb337ed9
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_401a3171_8776_4215_8722_896b18b68617
value: 0.00175
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_8439f02b_143d_46d1_a060_918c94225a1c
value: 0.1
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_06769038_9274_48f2_9d6a_7ebd9dc2cd6e
value: 2.25E-5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_9fcf4810_1e6b_446a_af21_7270598bf25d
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

COPASI105
fast: false
reversible: false
name: NFkB11) IkBb:NFkB Constitutive Degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_892da930_43a7_4dcd_8d54_92fcb7a2db16
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_39e49641_a3a9_4012_a1b8_16d358608023
value: 0.048
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#f5b277bb_2e00_4217_92b6_bc08782a6565
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

COPASI11
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TRAF6
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#fddc7417_4bc2_4799_be99_bd8c95c4601a
value: 0.01
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_06b85a50_7a40_46c5_a109_d622d8ffb555
stoichiometry: 1.0
species: COPASI39
type: SpeciesReference

COPASI93
fast: false
reversible: true
name: NFkB31) IkBb Nuclear Import/Export
type: Reaction

COPASI21
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IRF3[P]
type: Species

COPASI41
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBa(nuc)
type: Species

COPASI94
fast: false
reversible: false
name: NFkB33) IkBe Translation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#e276b495_0cb6_4540_b550_1e25ef82d3b8
stoichiometry: 1.0
species: COPASI42
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#a972c1c1_6fca_43f9_8212_ba1ae0155534
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#bd99ef65_7b88_4b59_9560_3726e89032ba
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_51955d8a_4e1d_4d52_ab29_cfb89895934e
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

COPASI31
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBa:NFkB
type: Species

COPASI12
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: TRAF6:IRAK1[P]
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#c0c9c4cf_2ac8_4507_955c_30903481f65a
stoichiometry: 1.0
species: COPASI50
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#e77853b0_7e8a_4b4d_ae1c_5ae50834b3c3
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_63793601_a852_4427_abc2_1b08db1fd44d
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#aa27a486_7ff5_42fd_9189_d729bb3a4963
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#fdb28d7e_8488_4673_a03c_8b64205698b7
value: 0.0225
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#d8b19d3d_0281_42b3_aff5_2785e69ad8cf
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d162592a_9040_4011_91ff_a92b702477ea
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

COPASI22
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IRF3[P](nuc)
type: Species

COPASI92
fast: false
reversible: false
name: NFkB29) IkBb Translation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_6a1a2b7d_9ece_404d_b0ee_65f918284de3
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

COPASI42
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBa:NFkB(nuc)
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#f4243976_398d_474b_8df1_6135fc4f574d
stoichiometry: 1.0
species: COPASI44
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d663ce72_7b3a_46c1_a05c_76922fd52235
value: 0.0052
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_936f7b64_ad42_491c_8e72_ffc223f1099e
stoichiometry: 1.0
species: COPASI47
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#adf2622c_5490_4d73_852d_fe20c61fa4c2
value: 0.07
name: k1
type: LocalParameter

COPASI32
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
name: NFkB
type: Species

COPASI23
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: source
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_1cf09676_2f1b_4177_b129_26c1a19134d1
value: 1.13E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_0f0dc4e6_8074_4af5_98b1_e0312bff7502
stoichiometry: 1.0
species: COPASI28
type: SpeciesReference

COPASI43
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBb(nuc)
type: Species

COPASI96
fast: false
reversible: false
name: NFkB37) IkBa:NFkB Nuclear Export
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_2e93ebfd_3dae_4ead_af4e_634147a44f16
stoichiometry: 2.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_759db4ef_b115_4e83_814d_dda2c939be82
stoichiometry: 1.0
species: COPASI29
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#b7e889d9_e007_4769_8714_86c193c18fd8
value: 0.1
name: Km
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_8cfcf5ad_65bc_49b2_ac95_9ae892949cd1
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_2f3c89c5_7f32_4264_8267_76d5290c2294
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_709bc3af_900c_44a2_8a0a_88567300f32c
stoichiometry: 1.0
species: COPASI18
type: SpeciesReference

COPASI10
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: IRAK1
type: Species

COPASI24
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: sink
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_57395771_9a16_4d4f_8197_43cb2e7f14d3
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_9855d804_e2b9_4faf_8852_3dfa6632dd93
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#b926b923_d69e_4e46_9de6_0f2b4f89dc86
value: 0.1
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_0a0520c2_70fb_42df_b5d5_7da4df46ecb9
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

COPASI44
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBb:NFkB(nuc)
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_0ef7988d_93bd_4340_a57b_3d0fc0e3a56d
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

COPASI95
type: Reaction
reversible: true
name: NFkB36) IKK:IkBa:NFkB Binding (2)
fast: false

COPASI30
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBa
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_7b99b99b_d0f0_49ad_ae99_e7c704a2072c
value: 2.25E-5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_67325d97_a5e7_4b9d_b022_95385007ae3a
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_7809fc28_ba19_48ec_be96_eaaaea25b1d6
stoichiometry: 1.0
species: COPASI38
type: SpeciesReference

COPASI35
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBb:NFkB
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_41c5ec97_9c3f_4d53_9f68_f0049ed3044c
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

W3 CDTF: Wed Oct 09 17:40:12 BST 2013

COPASI45
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBe(nuc)
type: Species

COPASI98
fast: false
reversible: false
name: NFkB42) IKK:IkBa Catalysis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_9672d03d_fa67_4a26_9ee3_78be77d04354
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#f2341fce_f9e1_40d0_ba2d_ab1bb208c702
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_46745089_a74d_41d6_b4fe_3f203fdf3389
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_2531a8c0_b24f_4f39_8257_d68c86d4b90f
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_9a5ada10_ca02_43fb_b255_82b93cce252b
stoichiometry: 1.0
species: COPASI45
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5eb83ff6_419c_4d99_8de1_0b18e722e699
value: 0.00408
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_0a3042c2_fb88_4bf6_9600_a8593b155fbd
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_3d9fa861_fd7f_4ec5_bbd2_c260102120cd
stoichiometry: 1.0
species: COPASI48
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d7113381_3ab8_4961_8505_49fe31fd007f
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_6578df6d_a425_4428_9dc2_e40eb61d99cf
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

COPASI97
type: Reaction
reversible: true
fast: false
name: NFkB38) IKK:IkBb:NFkB Binding (2)

http://identifiers.org/biomodels.db/BIOMD0000000489#c45c3466_e1ee_4244_8ed2_799f0bbfd525
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI46
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBe:NFkB(nuc)
type: Species

COPASI36
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]:IkBb:NFkB
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_1f0581b0_c46a_4bb1_9ada_eb5922161b72
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_32d9f04f_e3c5_4e1f_9d11_1280b010e7e5
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#e28e90a4_16cb_4104_8794_ec86275feceb
stoichiometry: 1.0
species: COPASI14
type: SpeciesReference

COPASI2
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: CD14
type: Species

COPASI33
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]:IkBa:NFkB
type: Species

COPASI47
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBa_mRNA
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#d1ca9db6_8729_40aa_aa1f_24f53c57a56b
stoichiometry: 1.0
species: COPASI42
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5c7ce5f3_b037_4654_8fda_9584ecea7be5
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#ea581225_6a01_4fa6_8dbd_d2c9d96d3c1e
stoichiometry: 1.0
species: COPASI20
type: SpeciesReference

COPASI20
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: IRF3
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#b1beffa5_ae4a_4b66_a80c_89b2bb4664a1
value: 0.00175
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_4fc44303_07c7_49e5_afa7_c584a5b4ddd9
stoichiometry: 1.0
species: COPASI47
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_76a28600_ed89_4028_8d82_b87fd3e65c56
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_1b0f8c77_e96e_4941_ae71_f43f29246bc5
name: volume
type: SBMLUnitsDef

COPASI34
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBb
type: Species

COPASI3
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: IRAK4
type: Species

COPASI48
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBb_mRNA
type: Species

COPASI99
fast: false
reversible: false
name: NFkB44) IKK:IkBe Catalysis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_6bafed14_8801_4de1_a7ea_f231ca3dc908
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

COPASI87
name: NFkB24) IKK:IkBa Binding
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_0e726896_faf1_43c2_a9ec_87fbe320bc40
stoichiometry: 1.0
species: COPASI50
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_62874f16_c4fe_4530_a96c_74110dde83d5
value: 2.25E-5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_99d86608_8eba_469a_ad9b_41aa88ed66c7
stoichiometry: 1.0
species: COPASI35
type: SpeciesReference

COPASI39
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]:IkBe:NFkB
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#f10a442a_0a6c_4138_9ed3_7b5eae495506
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

COPASI49
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBe_mRNA
type: Species

COPASI73
reversible: true
type: Reaction
name: NFkB05) IkBe:NFkB Binding
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000489#_6fe53818_fd9d_4dd5_96bf_af9d5373cd0f
stoichiometry: 1.0
species: COPASI48
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5dbb764e_0e84_4c21_8189_a8bd21e64241
value: 0.1
name: k
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_72fc5549_becf_4150_ac87_bbb64240b16d
value: 0.00175
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_486f02e5_1db5_411e_b572_c0e9487cc41f
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_56c3d51e_126f_4562_b478_8cec4356d97b
stoichiometry: 1.0
species: COPASI38
type: SpeciesReference

COPASI29
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: TNFa:TNFR1:TRAF2:TRADD:RIP1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#cd83aeb2_4631_44e9_a797_4db9554fef66
value: 0.009
name: k1
type: LocalParameter

COPASI19
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TRIF
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_7fb1969f_de41_4b44_b464_d926d00c799c
value: 8.0E-5
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#d34de4fd_b6af_4917_a144_14d549bcccd0
value: 0.5
name: k1
type: LocalParameter

COPASI88
fast: false
reversible: false
name: NFkB25) IkBa Translation
type: Reaction

COPASI74
fast: false
reversible: true
type: Reaction
name: NFkB06) IKK:IkBe:NFkB Binding (1)

http://identifiers.org/biomodels.db/BIOMD0000000489#_8020155e_d782_4ec8_b7dd_22a606a991de
stoichiometry: 1.0
species: COPASI47
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_4dd1383f_bf52_45e8_833c_cad255ad1eaa
value: 2.8E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_664ad81a_443c_4641_a4af_f3ebe10157ed
stoichiometry: 1.0
species: COPASI49
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_46767c26_5e1a_4864_89fe_baf7fbf85596
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_2907d89d_d068_4695_9f06_30979e5d34f4
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#af05aae6_43c6_4bdd_844e_cadba6f5f346
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

COPASI85
fast: false
reversible: false
name: NFkB19) IkBa mRNA degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#b56cae2d_7b6a_47a4_af0b_11d290fa18d6
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

COPASI37
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBe
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_7a6ae11f_1258_40bb_a17e_e485d2ea849a
value: 1.5E-4
name: k1
type: LocalParameter

COPASI75
fast: false
reversible: false
name: NFkB07) IKK:IkBa:NFkB Catalysis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#b7cbb9cf_d336_4830_8073_16d3cdaff731
stoichiometry: 1.0
species: COPASI35
type: SpeciesReference

COPASI17
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: RIP1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_187b2fb2_bd9d_4b68_aa73_c7fb00bff6f4
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_3775cf7e_6f08_4306_93e4_4c0b71d6c5e1
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

COPASI86
fast: false
reversible: false
name: NFkB20) Constitutive IkBb mRNA Synthesis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_52e9a9bb_064f_4f5f_95fa_044fb4fd21f6
stoichiometry: 1.0
species: COPASI48
type: SpeciesReference

COPASI38
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IkBe:NFkB
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_2d654ddc_a640_49ed_9819_d177f7305041
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#a6c45582_1261_4abf_8b75_02fb251c66e2
value: 1.78E-7
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_10bb7dc6_b3f2_4716_b5b4_576bf2e94fe5
value: 0.001
name: k1
type: LocalParameter

COPASI76
fast: false
reversible: false
name: NFkB08) IKK:IkBb:NFkB Catalysis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#_6368a8bb_3684_4d6e_b7e6_91fdc6259d52
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_8e2a2b2b_381f_4131_b549_fa6ede8b393a
stoichiometry: 2.0
species: COPASI40
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#a52d7758_7497_47b2_b1a8_6a03df78601f
stoichiometry: 1.0
species: COPASI47
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_5541d10b_4183_4669_89dc_202a124f3a37
stoichiometry: 1.0
species: COPASI51
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_8cf80381_8db4_4d1f_8bcb_438a2486c81c
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_8057f3dd_f607_46b4_a305_09fc21c7cfe7
value: 0.0165
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#d02abaa9_f4c4_499f_94f4_5e084281b117
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

COPASI18
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TRAM
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#c444ab4b_8720_43a8_b739_03e6515ab7aa
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_91d1c606_c362_4938_9041_7b503230fefc
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#a93b4359_f298_4791_ab1c_f9512993e69b
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#d1041fcf_a168_406d_a721_10931a5221d4
stoichiometry: 1.0
species: COPASI35
type: SpeciesReference

COPASI83
fast: false
reversible: false
name: NFkB17) Constitutive IkBa mRNA Synthesis
type: Reaction

COPASI82
name: NFkB15) Nuclear IkBb:NFkB Binding
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#ace89d14_6548_4a80_91ae_2c691deb1c6e
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

COPASI63
fast: false
reversible: true
name: TRIF04) IRF3 Nuclear Import/Export
type: Reaction

COPASI15
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
name: IKK
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#eb908b20_01be_4354_a545_390844afc6b5
stoichiometry: 2.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_7d9f97ae_540c_4c2d_92f8_4e630af37c91
stoichiometry: 1.0
species: COPASI54
type: SpeciesReference

COPASI25
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: TNFa
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_36f9e91c_2167_4fe1_ac8d_d026cf10565c
value: 1.0E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#fe378d59_0865_412c_a627_8e65fd39941a
stoichiometry: 1.0
species: COPASI52
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_89db4e66_7db4_46ac_a2c4_5850f2818697
value: 0.5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_811a087b_86c5_45ff_b652_4be8b5972023
value: 0.0204
name: k1
type: LocalParameter

COPASI84
fast: false
reversible: false
name: NFkB18) Inducible IkBa mRNA Synthesis
type: Reaction

COPASI64
fast: false
reversible: false
name: TRIF05) Inducible TNFa Synthesis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#a1b549e4_1aa9_47e4_ad0d_b38a0433a441
stoichiometry: 1.0
species: COPASI44
type: SpeciesReference

COPASI16
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_97543c6b_bf7c_48a2_bcf1_625f44da55b7
value: 0.09
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_2bd296c4_7138_44dd_89e4_dec34df00c23
value: 0.011
name: k1
type: LocalParameter

COPASI26
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TNFR1
type: Species

COPASI50
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]:IkBa
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#dde65087_236a_4d2e_a685_32d05b3bb1c7
name: substance
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/BIOMD0000000489#_528352d7_62d9_4f47_bac5_e5c1bcfdc34a
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_3b5fbf83_570d_4b90_95dc_394f305b2079
value: 0.001
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#_03537c06_3c33_4575_98fb_ce8b7bf0a056
stoichiometry: 1.0
species: COPASI52
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#aaf6a3fe_8193_4793_b00a_f45bf94bea5b
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_0ab2b0d8_5068_4011_8818_33c7efecb7d7
value: 5.0E-4
name: k2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000489#a9eb9aa9_2721_4e3f_86b8_8e8c34d78a99
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

COPASI60
type: Reaction
name: TRIF01) Receptor Complex Formation
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000489#_104fd013_ec44_4895_87bb_dc023c262955
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

COPASI61
name: TRIF02) IRF3 Phosphorylation
type: Reaction
fast: false
reversible: false

COPASI91
name: NFkB28) IKK:IkBb Binding
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000489#e1155398_b044_4f4e_90dc_ae49b22d1b50
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI80
fast: false
reversible: true
name: NFkB13) NFkB Nuclear Import/Export
type: Reaction

COPASI70
type: Reaction
fast: false
name: NFkB02) IKK:IkBa:NFkB Binding (1)
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000489#aa1d1e04_d929_4ce1_a8f0_54e25179592f
value: 0.1
name: k1
type: LocalParameter

COPASI27
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TRADD
type: Species

COPASI51
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]:IkBb
type: Species

COPASI13
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TAK1:TAB1:TAB2
type: Species

COPASI72
name: NFkB04) IKK:IkBb:NFkB Binding (1)
fast: false
reversible: true
type: Reaction

COPASI14
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: TAK1:TAB1:TAB2:TRAF6
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000489#_7894b116_1d6d_46a5_b7a7_dddfd61bbda7
value: 0.006
name: k1
type: LocalParameter

COPASI90
fast: false
reversible: true
name: NFkB27) IkBa Nuclear Import/Export
type: Reaction

COPASI62
fast: false
reversible: false
name: TRIF03) IRF3 Dephosphorylation
type: Reaction

COPASI81
fast: false
name: NFkB14) Nuclear IkBa:NFkB Binding
reversible: true
type: Reaction

COPASI71
type: Reaction
reversible: true
name: NFkB03) IkBb:NFkB Binding
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000489#cc2b56fc_5357_4e0b_ab16_c6b4956ddd0b
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000489#_90b9d1f3_3ea7_43a7_8d7b_b002193f6431
value: 0.0138
name: k1
type: LocalParameter

COPASI52
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: IKK[P]:IkBe
type: Species

COPASI28
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: TRAF2
type: Species

orgname: EMBL-EBI

given: Vijayalakshmi
family: Chelliah

W3 CDTF: Tue Sep 24 16:42:05 BST 2013

given: Gemma
family: Sharp

ORG:
  orgname: University of Edinburgh