This is a model from the article: Compartmentalized regulation of the GTPase-cycle by RGS. Croft W, Hill C, McCann E, Bond M, Esparza-Franco M A, Bennett J, Rand D, Davey J, Ladds G. 2013,submitted. To reproduce dose-response plots in the publication, the model is simulated with 12 different ligand concentrations (see parameter Ligand_conc). For each ligand concentration, a single value corresponding to total amount of output must be obtained, by calculating the area under the curve of the trajectory of species z3, from time=0 to time=30. These total output values are then used to build a dose-response plot (authors used GraphPad Prism). Mutant strains are simulated with alternative parameter values or initial conditions specified in the Supplementary Material.
Croft2013 - GPCR-RGS interaction that compartmentalizes RGS activity
GaGTPEffectorOFF recruits RGS from cytosol