Università degli Studi di Milano, Dipartimento di Informatica, Via Comelico 39, 20135 Milano, Italy
Mechanistic model of the Ras/cAMP/PKA in yeast S. cerevisiae.The Ras/cAMP/PKA pathway plays a major role in the regulation of metabolism, stress resistance and cell cycle progression. This model has been defined according to the stochastic formulation of chemical kinetics [Gillespie DT, J Phys Chem 1977, 81(25):2340-2361], which requires to specify the set of molecular species occurring in the pathway and their respective interactions, formally described as a set of biochemical reactions. The volume considered for this system is 30fL; this value can be used to convert the model into the deterministic formulation.
Besozzi2012 - Oscillatory regimes in the Ras/cAMP/PKA pathway in S.cerevisiae