http://identifiers.org/biomodels.db/BIOMD0000000474#_990665ba_832b_40ad_ab95_1590ed2313dc
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: SGK
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_1414dec3_1c0c_4315_9307_2245a8caaea3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9c4ac1a9_0f6c_43d6_a6b8_89c45f1d2768
reversible: false
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#d006da84_5794_4b34_90cd_6e9c033f8342
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_61a22640_a066_4f99_9cc8_daa23bac2b12
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fa186eba_dcad_43a0_8c31_07535978910c
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_84c1042b_1ed8_4bb2_80f5_2530a3c2b5ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c2f5a688_693e_45e5_a769_fe2cc67f0b87
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#a6911cac_7cf2_4e07_ad3b_4aa621576337
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6d00e1be_eba7_4b7f_8843_25eb7bb71e07
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a938b5c1_6dbb_4cd0_b023_f76dbbb0ae1b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2df4e955_cda7_4893_abb3_e8d211013927
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 500000.0
name: PP2A
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_23cf8ad3_b2cc_40a7_8a70_34ecf9a98db5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a25f24e7_3734_4561_8552_3920d1dde7d5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Akt_P2
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_2b71cd75_8716_4363_860b_6b2d45441517
constant: true
value: 0.033333334
name: k4
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_996eed86_dd11_4796_af39_1ee9c87007f6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d4c384d4_f96e_42ef_94f9_14affc46770c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e50f7c64_998a_4448_97cb_9f165b5e3eec
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d4164e3d_2966_4e19_9d35_5813bbed641b
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_40d8d8d4_5dff_4c74_b053_dd5b0e3544e0
name: R17r
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_6698cd6f_a6df_436e_afa5_0382c473bb1e
reversible: false
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_7b050974_fadf_4b5c_8992_95e1e69423ff
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2848974f_efe7_4dee_bd47_a439fe538fee
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f228ddc3_5d99_4d51_a209_caaf24230eae
value: 3.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4e9a14c6_45fb_4bdf_bcfa_c01833691eed
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3fe4be63_5e2f_413d_bb08_bab8050e4baa
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_57c63f98_563b_4045_8ab0_311a434d90fc
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_168bcd39_3fb5_4c3a_b63a_f11d1f100840
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_01318aaa_8459_4303_b4b0_289238bcddcb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_42362081_083a_44ec_a2de_8737ca444fa2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#de10938d_a0ba_4738_9dab_bc6f0b55e9de
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_11b94c28_684a_4bb5_9208_b8fe1b186738
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d210278d_ee3f_4e28_978f_5b8236c516a1
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e793020e_a00c_4ddc_9e26_c81a83cd42ae
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_699ed566_85be_48d6_8395_cfa6bf4a875a
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2934c7bb_b98a_41f7_8152_539bed7f336b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_54028842_cf3f_4ef6_8a3b_f6a3e493c794
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3b00a3bb_628b_4c26_81dc_7bdbdfe6ae9d
constant: true
value: 2.0
name: by_jnk_phos_factor
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bd9731ee_3e74_4832_aee7_13e19453aa82
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_481cce1f_3f08_4830_bb07_f6c6bc45b3ac
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7d62867f_311c_4a70_8f45_4cfd1738e9f7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4d61a633_56f6_4572_a5a5_f18a44001a09
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3a75c758_4687_4a58_9d9e_1bf974036d92
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_25952d6f_7b92_42f3_9362_bb6f26c36de6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c45c6e4b_bc3c_4d98_857d_26088b0247f2
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_871df1b4_5de2_42f3_9ad6_282428a94839
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4bffe407_87f1_4f55_a33f_ef30a58d2b4a
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#ac67a630_3643_4e98_82d7_a6e23203dfb6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d96cc6b2_5ee7_4b38_a5d9_a2b8bdeff78c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9419ba0d_5116_4e38_af55_a0bc7d5a0869
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_641cc56e_c9c3_487d_b5ec_aa57e87048d2
constant: true
value: 110.88
name: k14
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c33a500_822e_4045_a48d_eb36f4e7b5ce
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#da77465e_d0ca_496c_935c_0b1c27a6fb13
value: 0.0055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9b2637f5_466e_4db5_a624_608526ac86c2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3ddbc9b4_524c_4bc6_9477_b75e0292a339
fast: false
reversible: false
name: degradation of SOD2 protein
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_26742681_8569_4242_9460_4d70fd57c515
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: InR_bound
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#edef26c9_d1d3_4c40_96f8_41409ad60d94
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4ebe9575_41f3_4e01_bf70_2002e4636b95
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_80c4a7fd_eb1a_4213_9f26_4f9cc0189cb3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_20af7b78_e33a_495e_a070_c96ae447da95
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_801f1209_1547_4483_b143_433e04e8d0dd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_59999b6b_13d1_4cc5_b289_28e3a58465f2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: GSSG
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_8b955db1_7e70_4923_89e8_d8dc59f96414
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c47c0127_b505_4c2f_a80b_d2d57ef4b5f3
fast: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#a7b3ff8c_6bb0_4cbd_8957_f71fc57ff07f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bac1b75f_231c_4cf9_b88d_bbec404308df
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f34a6015_66f2_4b47_8528_ae08fab33da0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b23d4230_b8b3_4cc7_8394_60db14b8fa81
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5e8ecf10_4d1c_4429_b703_955458ec331e
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_72e94d50_5b53_438c_82b0_6de29eef4a5d
value: 0.0909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_85c5973a_6a64_432c_a892_3b21fe10affa
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_79da5161_740a_48f9_acaf_7cb92ca29e0c
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0dde7bb3_8824_4710_b135_055f394752fa
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#fdbffbf0_e2a6_4a33_be83_13b4c31ea6f2
fast: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c276aa87_32ac_4d4a_9955_fd31f8abcea0
value: 1.81818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f90a87dc_aae4_4060_8061_4484b9711853
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0f46e415_abf3_409d_9cf2_4aa688f793c3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3436eab5_57a2_4e42_9d3b_10239253429b
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

http://identifiers.org/biomodels.db/BIOMD0000000474#_0766dd24_5a0a_41e1_b89e_5688cd717cc2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4f80b43c_7f18_4801_8523_d0a53a33b6e5
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b40c3d37_82ca_41c6_8078_fc62c40ddb37
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 16000.0
name: JNK
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_99f8224c_4562_40e1_bb30_ea604992f3be
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10000.0
name: PI3K
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_2d177d6e_7cd3_4811_a5d3_2bbd171f547d
fast: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#ec57b6ce_b640_47d6_a11f_cd0e6d260be0
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 100.0
name: NOX_total
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_4fb5c807_a4b7_4baa_8fcf_a3155a6983f1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b8e92f2e_6dec_4737_b201_2d55485d31f2
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ba2138a2_4aaa_40f5_87c2_bba49ab0ab89
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ba06e8e9_1c45_49d3_8947_5dca92a6f497
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#fac24774_45d6_43d2_941e_0619a809e3e9
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#a82db891_c4dc_4084_8d88_eafcbb67e292
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_70d3ac9d_2729_4a21_981e_29c91ea6c36c
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f4e76661_77d7_48d7_97fa_fee590698d84
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: NOX_deact
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#df137750_1ff8_4023_b99a_e8445c2b38b3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2af9f53f_a3b1_448f_8cde_f5bb9ed1fcfb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_566a7a1c_4e98_4474_b8e6_45153319f086
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5110c8b7_40d7_46d3_8178_e0fec626953f
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#dee6c8af_cacf_42f4_922a_732f63b9916c
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a9311458_66a0_4f18_8996_1bc6b0433e8b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dca71188_8c9a_4724_8f83_6caab3d05023
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_8bf35307_b9f1_44fa_84ce_83220d0f736e
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_6201a9a1_9445_4247_b0f8_df44a570c08c
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_7174f7f4_daca_4d99_9636_c0346e9a65d6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_00fdec7e_a4f8_43b5_a904_93fef372ee56
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_49209c18_ea0f_4e71_a41c_3f9b6f5ddf45
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a173c1b1_dd37_4a87_9a0d_f4b17c7b944f
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b38eda2d_cf9c_4265_835d_d522705dcde1
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_7cf9c1c9_2345_4b79_b533_62dbc68277c5
constant: true
value: 100.0
name: Km52
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7f177009_0dc9_49c4_8375_22969ee998f0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bdbd5cba_a99f_4c61_b0fe_2a25d18e14af
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_14ca86bf_7b5d_4884_97ff_3c42caba3d71
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_00b73d36_bc13_4776_a038_d40619970238
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_283ff08b_6fb7_4955_aa6a_c8fb3d2dcbbc
type: Reaction
reversible: false
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#e3a00408_d660_48ee_bf5b_1fe13a0e9233
constant: true
value: 180.0
name: k36f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0c184906_84c5_4a26_8023_f64bc599fa8e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3496a0c4_5d60_4d38_ba14_085cb2799dc4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#effcab8d_1a34_40e0_9734_abf9f18482b8
value: 3.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c7f704aa_7cb8_4c1d_874b_e7f6b550c871
constant: true
value: 5.0E-7
name: k43r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a69fcd54_80fb_4f0a_9f73_d30c9fa6771b
constant: true
value: 7.4E8
name: ros_perm
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d40a53a7_99e0_49e0_825a_2c609d5bc6bd
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4533b028_1c91_4112_93b4_999c2cd096b6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_18b18d67_04cd_427d_9695_bd5a74f4c81e
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_47a0f8a4_4ce1_470c_9e8f_b41058fe7635
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#aa169e01_a50e_481c_b740_f5d0abffe690
value: 0.0181818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f45c65e6_914c_4c9d_b496_a9cd21a6f550
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b5e7725a_b78e_45fe_84e5_ac8987a9b8a3
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_4954e345_17ca_45f1_95e0_c2c52f2baf5a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6ead2e22_8df8_4651_a4e9_8a851dc43acb
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: PTEN_plus_PTEN_ox
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#bda14b44_a63f_4df4_953a_288dd91227a4
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e6be0ceb_4672_42fb_9c27_6f00f7a3f9d3
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e7413d09_3bfd_43df_ae20_d3ffe8fa2de2
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2d702eef_3738_463e_a8e2_3d19ed6e466e
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#c3ccc956_70fa_4598_820e_e9a909e4d0f4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d9f35c26_41f5_42b1_9c2d_51952a67ffd3
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3cbf3113_da3e_44be_b122_d79fb1fa9314
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_7f81f4e0_e308_456e_b8a4_a08510d0d9ec
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3b49e0af_bbf3_40b0_a679_cccccf775bf8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a923ad56_01cd_42ff_a21f_0169428b08fc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e3a57191_9e69_43f6_bec5_bae179c22c93
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9f727037_9963_4606_90dc_4019f10d9f9b
value: 3.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_65f13815_a223_4105_86b5_c0f7beb0e262
reversible: false
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#f40ea9f3_4d1f_4485_9e21_365e4d8358d4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_312eb86a_88d8_4b40_b142_93f6ff3dbb62
fast: false
reversible: false
name: degradation of InR protein
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_7ff079e3_fd41_41b2_8d36_00517cf77100
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_319e54c5_9918_4b51_914b_8475ed29cfff
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#afa4a214_8236_4bec_b291_674c65f35c56
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e14dcbcd_a3b3_4ec2_a020_fee6e3395c15
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#e47ad615_1470_481b_9ebc_141b9a9f591b
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_5f1b8e6f_042d_477f_8b6e_549ce2c421c7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6c33e273_5257_4ac0_bdcd_c77a3164f4f4
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_949372cd_5f6f_45f5_b0bb_bc882ce3db49
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_27b54553_12fb_445c_ab21_a2ff7d9e202b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1fa71611_e14f_4292_8566_bd7126843b7c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e7b37c1b_6edc_4617_9843_98cd3f9c4d14
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1a1c3ba4_9c6f_43fb_b011_64174ea1e8b1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b17fb7c5_e84b_4871_a3d1_4d0aef185573
reversible: false
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3156b3f1_783a_4d2b_be6b_9fd7f32fe92b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7bbc4069_7f52_4bc5_871d_5cd6d04ca41c
fast: false
reversible: false
name: R7r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_362071c7_ae9f_44e2_89fc_802a1641d521
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_1ef413b4_9233_4c3c_ac4c_60eb928f70dc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_19229b57_7f02_4eb5_924a_71212a625312
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f6f13aff_6b62_45e0_95ca_ad09d03c62d3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: CDK2
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#a584c56a_ab2a_4bbb_8fe2_78cca25b3d71
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8d54b5ad_4510_4c65_ba0e_ae66bbdb871a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_62d13e61_2a7f_424a_b672_5ed05eaf267c
reversible: false
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_1d67112b_a11c_4e51_9126_7c9211821718
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aa63623c_c418_46ca_8752_e113ea865b15
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_80655017_5119_4f67_9fb6_eb5956cba06b
constant: true
value: 0.001
name: k_irs1_basal_degr
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5884736a_63d5_4529_9cad_ba1e23048566
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c8770e9c_338a_4c48_8e14_026522a1b7e7
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: InR_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#a5b52ef8_e8a2_40db_8d0c_5f626be74eef
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_71469691_a227_4ea4_a8a1_be9d3b1eadc6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2c567f31_418e_4965_b033_55b3fef0c1b7
fast: false
reversible: false
name: R5f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#aa0b1a44_e844_4312_8023_d04ed6daf32c
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b70aaefb_453e_4d8c_8bba_8f04d73cf5c4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a0cf80d_f640_4d46_90c7_a3fab9ecbeca
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6773779b_788e_43c7_973a_008e61a3096b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e35f4096_7e34_45e2_9e23_72d168f41ec4
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_54ba6f26_6980_4b6b_be4e_b4d08eb8379c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_018a9673_650c_4a3a_8f63_ebe2a06eac25
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8521c1fb_b9a1_4b6c_87ed_29dd68558277
fast: false
reversible: false
name: R2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_52a1305d_4834_48f1_b150_aa425c364cfe
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_75da58b3_0c29_42a4_9e4a_8a2dee121e7e
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 2000.0
name: IKK_plus_IKK_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_596790e3_8d21_4837_aaba_cc7161b4281f
fast: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#c90ccbbb_40be_4a94_8821_b2a77588147d
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#cb72d4e1_bfd5_4446_bd4b_3e699cbff20b
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_32dd5508_cc6c_45ee_ac3e_520d63194b60
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Ins_InR_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_15fadc57_fb3b_4e62_816f_664d8035968a
constant: true
value: 90000.0
name: IRp
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e7876e15_254b_4374_9f38_b559d2b696d7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d59cd6eb_ebd4_4827_9880_f0a6bf02a4e3
value: 0.055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c4db2cbc_45d1_425f_b90e_135734778350
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f1d474e5_efc1_4227_b871_2dfdf83be46e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_967ba165_724d_449b_9af2_2cc01107cc9f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0db26aea_bc92_4b07_a969_19d6a5d1d0c8
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8712699e_c56c_44fa_a995_07d011fbadbe
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7f1cffbf_31f1_49dd_82eb_cbc669601c21
value: 0.55
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_12a39a0a_7b48_4ef2_b83d_c42b52c8171b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4265dbcf_9a9e_4f25_a0cc_21fe830edbf3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_17639d6a_574a_4296_a145_96dced5cf3b0
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bae307d8_31ea_4cdc_8551_9383cc58a29c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d2da9934_bc62_46af_91f2_852af54d9505
fast: false
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#f6942c22_4f05_4b09_bb41_0b824ed89017
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_80bd4435_8abb_4017_8f5b_d3f326f5d3e4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0839c2eb_9d7c_4fb4_ad85_6924344ef8ba
constant: true
value: 3.5E-5
name: k12
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ac0468a8_0e72_4735_91df_49d085f5e995
value: 3.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a5f212c3_a780_4dc2_ab4b_b211cc152f21
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#acfb9f13_4498_4f8f_bbf7_7b772bb1774a
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#acf70f6f_327d_4fac_92af_55a52f0771d7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d5b7bc25_f8e4_4b20_89f3_a1db2ab8f65d
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_7072e73d_3f76_474c_8f35_7cd92b98297b
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_52de7c15_d54a_45f0_9acc_08e7176c7ef9
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f9704a69_16b4_4192_b754_fb483203d643
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_74b0fec7_66a6_4612_ae38_d43974cc729a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_987c752e_1c06_4728_932f_53246b88ec8d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_586cf02b_0825_435f_a421_636b93061b4d
constant: true
value: 90000.0
name: kminus2
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7c68250e_b13a_4bc4_98a7_4137371f53ea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f8cd27b3_6837_4b60_b99b_fc7027a4ff06
value: 2.2E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e485f7bf_74e5_470f_8b0a_20114b4e758f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bcc2e946_16e0_456e_9d5f_a1e4a03517ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c8aeed6f_47e3_4417_8f1a_46eec87da0af
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4c2645f8_81f9_4c48_bcff_b5b0baecd1ac
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_00772d53_7110_41f5_af50_16807ab479ab
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_363cfab6_2ecc_473b_9628_ff6569642add
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b7918e83_0abb_44d1_905f_3cca0df38eaa
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2b0e5076_2029_4fb1_995f_c891c66f820d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f44c4b8c_f85b_4922_94bd_64fe4ddf395f
value: 0.00909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f04cc99f_c147_4a22_82d4_214265850bf8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5e489470_5035_40bb_a7b2_3b6bdd9c70f8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1ff84519_ec9b_4b63_8408_d4c503ff1614
reversible: false
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK

http://identifiers.org/biomodels.db/BIOMD0000000474#ab37eb63_be3e_4963_b620_7d5333b7f26c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_05419987_9e49_421b_ba1c_f654ab19939d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_114c4a56_7dd3_4c72_a4f3_a50c6fa24941
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_52a42fb5_0b52_4aea_b875_4495ba7c7b94
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#d78ff30a_31c0_46af_881a_27edf7c8371a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5232a49a_89d6_48f7_b84e_de2f2fd6efb5
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bfbd99e3_d17f_48bf_a47f_7a57993f9236
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_766a3758_636c_4a54_8f3f_f305cb210278
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_9448fc39_897d_4c5d_8c32_57e8abd95fa2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a8b8da3d_64a2_47c2_9c94_9bed5853562e
fast: false
reversible: false
name: R7f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e652d4aa_66a6_4458_9d61_4df60cd14d5a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_101ed40a_6b70_4cd8_8a25_40895e923b4a
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_15e1f565_0283_4224_9987_75dd1fa7afc0
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b3d1bb3a_ef21_4b0d_a9d0_34038600d530
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e25a1f8b_e0cc_4b61_bebc_193b93737641
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2f6b426a_0c13_42aa_ad81_5505a24ccb08
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_639c1081_5375_482b_a54b_b72f0bdad801
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6a5cf3b7_dae6_4b7d_a96a_6cab3d8b4596
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_394e3f20_c413_46af_8ff2_9948ec732f49
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_7c81346f_5008_4ff6_b06b_f9c0f10d0f3c
fast: false
type: Reaction
name: degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#c61e471f_a0ad_47a0_b9c6_535188d2c5aa
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_87f11775_2b08_4920_82b0_138fe2f59445
reversible: false
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_66eb79fe_92a2_4f00_9c00_d04706b2676d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ea2cf27f_09d3_4568_afbd_07026129e1f8
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ac51af2b_3863_4965_a00d_f01328e39ca6
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_4fc2bfb8_fe74_4d92_b518_22e2c980b103
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: DUSP_plus_DUSP_ox
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_104f3064_3a84_4e61_8ca7_3196006c8ff2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_1f78d99d_dcbb_4fcf_92b9_6df7a71de810
constant: true
value: 2.2E-4
name: k2psp
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b65dc81c_cb8a_43a3_be41_c7a7328e0b92
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7cbcbf75_8900_486a_90db_0103747bd138
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_974fe3da_e382_4991_87f2_74225a461e93
fast: false
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#a5257d8a_31a1_43dc_9bc7_ea6df04b3bdf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c8e48fea_082f_4c68_a847_5d5fad9bdb46
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_02500797_3745_4f5b_8d75_429b532936ad
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b4b890a6_234b_4b47_97f7_091e7d47731a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dcf076c0_5d92_46b1_97e4_b8255e021d7f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b5ef99b6_5c26_4a93_94b2_7cc1b69f3f5d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4664afd0_39ad_44ee_ac95_b0c9f93205c9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3fb1d2f6_5884_47dc_8108_4d346ed1fa5e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_336d6127_0a1f_441a_bd45_9cd1d05f9950
fast: false
reversible: false
name: translation of SOD2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_24f42c2c_8a91_4d85_9758_008c2f2fd2a4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1af929f6_5f03_4882_bcca_0af64c1f4660
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aefa6619_2a4a_4a56_a2ae_ce8579ba92bd
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1fa835d2_de67_40ff_ba9e_eaf9acf430df
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#dbfaaecf_8af9_4de0_bd65_6c998b4d393c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_34212223_dd70_43c1_afb0_0ba89ad54386
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d6a5cd86_ca37_483c_ad49_98efba211b49
constant: true
value: 3.33E-4
name: kr16a
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b7bc1ca0_c4d9_4c90_85ae_ab1b52dbabde
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_33f9fc96_8fb6_4af2_a0bb_431b9da70b9d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_96d2b1a7_6adc_4124_9d71_c1517647e69a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fcdeb2ea_652f_4147_9c71_d5e8dedd6f0c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d3e5f560_7b3a_4f23_9ebe_c245deb47cf6
fast: false
reversible: false
name: export of InR RNA
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_1899097d_1bca_4a02_8d12_4d224039cbd2
constant: true
value: 0.12
name: k35r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f3ded55a_1c77_4dac_92ef_fa7d3c01cc3b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6dcc490c_00ea_4e3e_ae3c_b4103a5caf05
constant: true
value: 3.0
name: kcat82
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a63ecb51_fcac_4d7a_bd90_6ddcbc09e914
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_43bcea9f_e805_4ae0_876e_f2caf6456648
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_08453b11_3bc3_418e_b961_79d6b1de9e83
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0eefc13e_ed38_41ec_8921_f1066bcc0e09
constant: true
value: 7.5E-6
name: k13
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3fb01d1d_f174_41b7_be04_7eab103a334f
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8e35eef2_77ca_4302_bb72_5ec78922293b
fast: false
reversible: false
name: R6f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_58bf4eb6_e400_4a17_96b5_6a33631e9408
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 300.0
name: E2F1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_24e3bafb_0a06_4306_b5dd_c0c6c1b48140
constant: false
value: 0.0
name: ros_ext_conc
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7f998fb0_0f1d_457f_8161_d8169e17613a
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ca4fe026_bc2a_4589_bec2_1fd9c32224fe
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_597d61f0_c061_40e5_bef7_ecb44845bc43
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a864b6f4_21d1_4b4d_bc77_dc20635af1fd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2063d335_de7a_4c59_bb40_b3dd5b6b4ec3
value: 1.0E-6
name: kub
type: LocalParameter

BIOMD0000000474
name: Function for R30f_1
name: Function for R36f_1
name: Function for conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A_1
name: Function for transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0_1
name: Function for transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0_1
name: Function for transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1_1
name: Function for transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1_1
name: Function for transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P_1
name: Function for transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A_1
name: Function for conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P_1
name: Function for conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A_1
name: Function for transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0_1
name: Function for R50r1_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P_1
name: Function for transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0_1
name: Function for degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1_1
name: Function for conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P_1
name: Function for transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0_1
name: Function for conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P_1
name: Function for conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P_1
name: Function for transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK_1
name: Function for transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1_1
name: Function for degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P_1
name: Function for conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A_1
name: Function for conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A_1
name: Function for transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK_1
name: Function for transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0_1
name: Function for R50r3_1
name: Function for conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK_1
name: Function for R12_a_f_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2_1
name: Function for conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A_1
name: Function for transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1_1
name: Function for Synthesis_1
name: Function for conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P_1
name: Function for degradation of SOD2 protein_1
name: Function for transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A_1
name: Function for conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A_1
name: Function for transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2_1
name: Function for conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF_1
name: Function for transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1_1
name: Function for transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0_1
name: Function for conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P_1
name: Function for conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2_1
name: Function for cyto degr of SOD2 RNA_1
name: Function for R12f_1
name: Function for R34r1_1
name: Function for R6r_1
name: Function for transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0_1
name: Function for export of InR RNA_1
name: Function for conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF_1
name: Function for conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A_1
name: Function for R4_1
name: Function for conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P_1
name: Function for R31r_1
length unit: length
name: Function for R20r_1
name: Function for transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1_1
name: Function for conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A_1

http://identifiers.org/biomodels.db/BIOMD0000000474#a92a0061_cd55_4a1a_863f_6f6801605ee9
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_62a46bd9_561f_4b8d_bda6_a367bc080f2d
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_510f1156_3834_479d_ac02_4ae9fbb1d557
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b98a5374_a9e8_4764_b831_2272a7842b7a
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ede64527_117c_4155_94cb_6e6f2fd8d921
constant: true
value: 12072.0
name: kminus1
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f70b151f_0ff7_473d_a671_26fad4d72532
reversible: false
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF

http://identifiers.org/biomodels.db/BIOMD0000000474#_37aa7d6b_66f0_40de_b266_992d47cc0c89
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fd92bd9a_e8a0_4d6b_a4fd_e3d3b3342b7c
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_41a96032_8963_4f57_9277_89f05da9ff8b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_26205efa_a408_48a1_8186_e3f577ad8d98
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6d370fb6_67da_49e9_b1a6_1660a9d07ed9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_RNA_InR
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_8ec4538a_a775_4d28_ab12_936d44b06301
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ea03cc2d_6005_4b57_a33a_842a614eaec5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0aed0ffb_c7c2_411e_b725_9fed903813cd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f6b0a355_2d0c_412a_814c_340e4bc9bb7f
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_72bdabb1_9dbf_4d57_98c5_28b0d00afb59
value: 1.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#cad54753_6a34_471d_9f61_643ccbe53b36
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#f753d57e_c6c8_4d33_9be7_21b0d326cdac
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#c6fb8dc9_7cdb_400b_9b3a_60e93e0967a4
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#da3dd209_dc7b_4b9a_a10a_769f21bdc699
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_45577caa_4d20_45a7_a644_bee4aefaf691
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9c247133_02b8_4c51_8253_c1d82f864f0b
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_10647ab5_72ad_438a_ac95_e8144721488f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fe967656_4254_4a83_82bf_a9acf38d9e38
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_442bfe43_93de_4186_ae0e_edae1d04c0ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a7818de6_5471_4eb5_8491_7736cf54beae
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8c0bc2c1_6950_4990_80d2_59111f85716f
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_109552b8_eebd_47f0_b037_ae09d79559ce
constant: true
value: 5.0E-5
name: k43f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b2157d38_27eb_42f3_8c30_0dbbff2fb495
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_51cd5cbc_e3ee_49d1_9b84_676d638d183a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_14fa3264_237d_45ce_8eba_55a4f4b72b4a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_55e29352_193b_4f08_b171_4043621d7907
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d6d7bfd9_9a19_4599_90e9_47095afa48f6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1249f5dd_6bcb_4c72_b522_7b6596a34e2d
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_546b89ee_5e8b_4791_875c_73de58897f5e
constant: true
size: 1.65E-11
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000474#f403d221_cb60_46b4_8087_aa15234dd681
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#f4845f68_457d_4e95_9973_0a81d943e3e1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c22ea221_ea73_4bb9_8e76_35b93a001661
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_46d4870a_e566_43dc_b98d_1dcf32723322
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c5ec97dd_b849_4671_8965_f2838538ad43
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9277f603_f485_42d6_9a45_8ca50ed13b41
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0cce416a_5d19_4026_84e2_735147d3c667
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_45329dc2_7392_46c7_8652_6c52f4b9f784
type: Reaction
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#df3ca002_83b3_4190_9444_1eb54a1d2b60
fast: false
reversible: false
name: R50r4
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_5de842f9_13ef_4a8a_bf95_d31fb7617334
value: 6.6E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f3ae8c9d_d81d_4fb7_83f6_3a541c5f5e63
type: Reaction
name: R31r
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_7707b6ea_c1b3_4da7_bffc_cbfa17e35a05
fast: false
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#de4d3793_aa63_4167_8005_5bbb42d16a7d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_02e4d4d5_57b5_45fe_9deb_bc0dfbd243f6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a994ff33_916a_4148_a640_38cade125384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_215e6a08_2971_453e_b6bd_6c71e980b5df
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_76e66abd_6bf5_4b6e_939f_d61bb2e7b049
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_99b85eee_3973_46c0_997b_49e53f340975
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cbd64027_75db_40f1_b4fa_d837e6295444
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5fd72522_c0f4_4f28_a2aa_01814d0eab15
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ab1704b7_1129_4dfe_b072_bf6918ef58c4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_6ec79a9f_e302_44b6_aaa4_d6a985e6c66d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c8e1a3da_560a_47eb_b995_1436ed064084
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a1c53e38_66ce_4613_9c9b_979302092dbf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a98a0b9e_8f2f_4906_a613_bf9af0c99b4e
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_67db57d2_0787_4ef0_beb2_71fa69025cc5
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9d167ccf_ea34_4db9_97b8_f3cc16deca5c
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_37a3caab_c18a_47d2_861d_e4554cc9a84d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ea31fd3a_abaa_47c3_b33c_2da16d6b9a63
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_354a2e23_3b07_4ea7_8756_1990ba2297f4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f1463262_3ceb_481a_96eb_5171c00e3981
type: Reaction
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e4e55e1f_12c1_4930_bb79_e387562d023f
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_38a09f60_562b_4284_8d77_ed07e49d78fe
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_22ad17c4_15fb_45ea_a5fe_7fb9b351dda5
reversible: false
name: R12_b_r
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_5c810f63_771d_4727_825f_76bce8702a65
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a1e7bc9e_9ca1_42a9_9d32_06fc7d0f8ea6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_76def0bd_32f2_4dfa_8b58_8035a227eeba
constant: true
value: 4.0E-4
name: k32r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b9e639bf_fba7_4753_826e_8e2011d09f1c
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ce9bdde7_d835_4006_b7a7_90524b814c7d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fb4f30f4_faa0_4cd9_adc6_8cf6eaad761c
name: R11
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_282f3c73_a08e_4765_8969_1d4d5718ab83
constant: true
value: 2.6E-6
name: k8
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6a518b4e_3afc_40fd_8649_f5e543d86b28
constant: true
value: 8.75E-5
name: kminus7a
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#dc2a9fbb_aa33_4219_b086_520c70452911
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_0ee470bf_6b26_4568_9f45_b51b9755facf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_95697aeb_75f9_4556_81bf_bb9406defb2d
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_97e69bb0_07e4_4664_8bcb_477ba0ca0a48
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8645e06c_5a3c_4df9_a9c2_42754fe0dbca
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a0fa3727_30f7_43ee_8e16_ce866e38bc09
fast: false
reversible: false
name: R3r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_9903281a_009a_42ff_9f3a_8ec95f995ab1
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_86dc098f_712f_43ce_b7ae_141a357cce88
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_314d252c_6f0c_44f3_b033_3fe9040015a8
constant: true
value: 0.13145
name: k9_basal
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_01256aa0_9f78_4d62_bbc0_a32e70c8b50f
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b8cb12f1_1a43_4442_b475_c95cb19dd170
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_37e51cff_9e75_4f3f_b948_987a077bad3b
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_34769fa3_b61a_4c8e_b089_d200baeaed25
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c0e99556_6dd8_4d71_a096_cae06f23afb3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dbccd3e9_86a4_4729_99e9_97956df7199e
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_78589e2b_7e93_4428_928f_44cfc3e9fafb
type: Reaction
name: R42r
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3745f459_e25f_4b21_842c_6f1b6286c790
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_583ae3a8_28c1_4be1_9ba6_0106ce52369c
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_4629c8f6_fee2_4e05_a10a_833222f4402e
constant: true
value: 100.0
name: Km82
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2c1f8402_94c1_4fc3_aa43_25d89a0c84cd
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#eab0832a_231d_40aa_846a_d225429db177
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b071e7f5_41a5_4629_9aa6_cc8e8ecc9e54
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_25504b82_50d4_4710_9f22_cee8cbe17d37
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8d27c3e1_6703_4fbf_be4d_117e01120787
constant: true
value: 450.0
name: k35f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9b5911fb_4566_4c58_bd07_a2b473db3883
fast: false
reversible: false
name: R6r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2075f5cd_b153_4de3_9806_7b3aca72486c
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_39f5566a_eaf1_44d6_94ab_a62d1796ae4b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_92e9c67f_95bd_4535_bea1_1f4a4a59be7a
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_86a3048a_0589_487f_bc17_f2e77c89cc27
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#af6e5be2_45ea_4b00_962b_a29f254c950d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9e42d7cd_9b5b_4e63_adbd_f902bd376723
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8d6805d2_5d39_48d8_8152_e2271e96f083
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: SIRT1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#c18e583e_e1f7_4d4f_a7f2_79caf343e77c
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8260b527_f669_4b04_86ce_d4cdc96230d9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100.0
name: GSH
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#b831777e_4ab1_4292_b923_8eeab0b37d5b
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d38fd5e5_3841_48c5_9ae0_537f43e8f14d
reversible: false
fast: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#aa3fbe8d_1bc6_4a13_999b_0632f59e0587
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#de332333_24c4_400d_966d_eaea43d07993
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5ef021c8_6891_4229_9c0d_63f060eb15a9
fast: false
reversible: false
name: basal transcription of SOD2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_06b2a8b7_037e_4dec_8a80_e62d4f0998c1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d84ca06c_e197_483d_aff3_47695dd5349b
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_46d84af6_50b5_4b3e_bdf4_e587e3148666
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3134e8ff_c254_441c_b4f5_14ccb52f10d8
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_76862eb0_a115_4d8a_b898_657bd0df8cc7
value: 5.5
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_594cda85_36f9_4772_9105_1988426c6522
reversible: false
name: R16r
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_7651be05_501e_45ae_a1bd_1f1b7813a3e7
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c99d61e3_2287_4089_83b2_f95546c3b42d
value: 0.22
name: kexp
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7c7ab9e1_8842_4bef_a4b2_bc5eac864094
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3afa8934_6641_40f3_885c_09037775a3d9
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6643bc6e_4ff9_4617_84c3_36ac4f4fb51e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5bb7bb42_d4e9_4f55_8b05_f4eeac21e482
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7d4ffc35_ad82_490b_b54a_16d92ee48953
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_291404f9_a84b_43c1_8144_0bfcc224f925
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: Foxo1_Pd0_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_6338570e_601c_418f_a8de_a147332b93a5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: AS160_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#aa8c992e_f62d_489a_8a2a_7e0c4ec85821
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_52bb23e5_3bcd_46b9_a01a_b8e5134854c3
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_8f00325a_a4f1_48d0_a5e9_d0b0a8f8a8cd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8bdf2508_ba8c_41be_a1ca_446f3e1c0382
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#cef9605a_b1f5_47f4_a33b_319a4b55ee37
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_34111640_dff5_4fa2_9a74_a4e33fa7bac0
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

http://identifiers.org/biomodels.db/BIOMD0000000474#ac37982f_86c8_4689_8270_009abbb329c8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_333e0a32_108d_44f8_b716_103d1a1c1273
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bdd5c1f3_f947_4b05_bab8_86f0ee8cecb8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_33ea046e_51ca_4740_b2d5_f74118f768e7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_67ffe83b_5274_46f5_ad49_66bf43919fd4
value: 3.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4f3fd337_3126_4c66_a8c0_e7987741a06d
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3a42e051_d0f4_4f47_b99b_103e174d7302
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_06d5ea88_9839_4165_b224_a4d2b154eb84
constant: true
size: 5.0E-13
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000474#a8ef5078_5a82_4817_9ca0_d0fc46052f83
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7491c75e_e684_4c1b_9fb0_6f3e9afb22bf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c031b589_c006_4e18_93d0_bf822ad540a8
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_2dfb92e5_f5e8_4925_882c_5a77b18d68fa
reversible: false
type: Reaction
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_212aeccd_4eb0_4ba6_8cb8_21b6543a6c82
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7a357790_d69c_43be_b1c5_cdeeeb9fa604
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#cedc5de0_a2e0_4001_b39b_c9ec4015d7de
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_32bcfc79_530e_4801_ba50_662b5c1e51d9
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2bfae1dd_956b_4c2b_900a_3892f0d653a3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: IRS1_TyrP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d128d026_354e_45b7_ac60_765ee66d5576
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b97cc7b9_ff3a_4716_b8a8_033c726bc7f8
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_652747b2_354c_407c_9dee_9680991fa150
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7a890840_aaee_44b1_bdd1_0278f01c3a4d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ba127c1f_ae77_407b_b60b_301693ef9185
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#f2f4b3eb_f32b_47e6_9830_eb727ec92d4d
fast: false
reversible: false
name: Synthesis
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d30e8021_17ff_49cd_9367_de978c16e284
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dc72fe5d_74c2_4e79_b417_a84b282d52cf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7cebe784_245b_4dfc_b9a2_3deb5442f216
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4eac3aa5_0bf5_4d6e_8ca5_ac28939fb496
fast: false
reversible: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_7903e070_387e_4b8e_81a0_14c72beff502
type: Reaction
name: R35r
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_97a86966_fe92_4371_be08_d1762d1edd4c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0b7b1e45_9934_4a6c_9b8c_09fbdc0bd77f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bc19d622_9f0e_4bbf_935c_3afe4f2a7495
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_176f4999_85aa_44dd_8660_29ce15c58303
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e1b6c8b1_0da9_4c5c_b712_d2ad2a59c949
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#ef7c1289_16d7_40be_ac30_7f720ef8dcdf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fa0cdde9_43f2_4e78_83c7_5d8d43f179ba
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_64cd9f8d_d316_4de9_a58b_0ed9d191d117
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9ea221f0_d2a7_4176_bbb1_05a996240ea8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#df79f405_2d00_4d8b_9112_550de0ac1556
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_80dc1c19_a963_4ab4_84c2_a83d22e0ba2d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a152ba75_1cce_4c1d_bb4d_96144ae54bdd
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_811eabf7_6da4_4ece_9f05_74ee022e130d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_79c9b9cf_5710_4f41_bf49_c3a8f537ceb7
fast: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_1fa89bd9_ffc9_4418_9446_697c6e1857fa
constant: true
value: 0.0014
name: kminus9
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_151f8c59_4231_4f4e_bc00_939ddcb814d7
type: Reaction
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF

http://identifiers.org/biomodels.db/BIOMD0000000474#e02fcf0e_68cb_4679_b7af_79c03e09e1ea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3998f93a_7adc_4437_90cb_86503740c79e
constant: true
size: 6.4E-14
spatial dimensions: 3.0
name: cellsurface
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000474#_77af368d_1d1e_4b89_9d4f_9266ab30536f
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6f2bf5b4_f263_4a45_843c_b5712c89d036
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_32bab348_90f3_4f27_a923_e000afe9b884
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7a007c5f_4540_41e1_9e96_5f88f44c3a1c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2c50ccfc_7d7d_4028_aaac_57b9e9372628
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_318d1a66_7e4f_4cad_af60_824d52afed50
type: Reaction
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_47a05cb2_de58_4e8e_9806_c7f2ca9db711
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_95934815_92d1_48f8_b58c_fb5c80002dd3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_50cbfd84_227e_4058_ae04_6c6cb79dfa89
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#b60b3be5_25aa_41f0_b120_4a367d8939af
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b2188daf_2136_4b64_814a_eb4a87ce924c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bba25b95_b652_4014_a7e3_13cee2304e24
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c105d429_4c8b_49b4_b373_1b0c0ba9685d
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: InR_active
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_04f62566_8ffa_45ce_8bdc_b60f2458a7f9
value: 0.0909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d017c8d6_f6ff_4149_be7e_30d3e09bddf5
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_42885815_d1c2_4bee_8fb2_3b269c1abfa6
value: 15.0
name: v
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5bf72c7e_f017_49fe_b27a_ada235f0560c
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_0f3b84e2_7af7_4cf3_8b3c_9766fa869d00
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e44fa838_214b_485a_8492_f55b0bcc4b43
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_91aa4ae2_77a7_4e77_99c5_038e80063574
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_252bc779_d699_417d_80eb_68a3d4f3c204
value: 0.909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e902d954_30b4_4d98_8fbd_59ba1afab04e
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f102eca3_f067_42d3_8f9f_04b8c9250716
type: Reaction
name: R20f
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3d3be43d_5649_42c9_99cf_a36bcfbbb039
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_525adf52_4eb4_44f1_94fa_1b1e6b4949dd
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: IKK_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_1db72522_41c7_4fd8_b4f7_1c51a47be66e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_50d17c6e_438d_48a9_a07d_fa0cd65de583
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f94a5f3_b80a_470e_85ac_07474015fedb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4eab3cbf_3ec6_4a89_9b02_3088326ab768
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5c704d56_4f1b_4e28_b47f_68263fd32d3d
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: PTP1B
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_84f56da1_f905_4f0f_b213_84496ed0db07
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4de4c57e_78e1_4be2_ae5d_e8b676583551
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c00bedd3_aafb_46d1_8e39_6bc216a46445
reversible: false
type: Reaction
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK

http://identifiers.org/biomodels.db/BIOMD0000000474#f7bfee60_d78d_4b64_b156_57d705243491
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e85f966f_f1a9_4936_a6ce_2a59e6fc65d2
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_62202c93_e6b4_4127_9933_9037bdb396e1
reversible: false
fast: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e96c9959_c135_4773_8781_e6d70c143a3a
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_75b55a0b_a4b9_49c7_91a6_a6bc9b33a2e2
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5be58ff8_d3ee_4916_9ed2_da5a02eb9a77
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_81753648_7374_452f_8c0c_cfce17e8bbb4
value: 2.2E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c865bf86_908a_4e2f_be52_42073b9ccbce
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_47e399ff_7b9d_4799_877e_7dc19802929f
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#aab84523_017d_4481_bc79_682820ae3439
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c9646d92_d10e_4656_b6b7_830903273180
fast: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_82d6a5c4_9305_4779_a7ee_7838e76bf9f5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_48b6d738_8ce3_4a14_aa7a_657ac21324b6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b6e97172_5fb6_4dd4_8767_07f2d07ecded
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fc4a63a1_530d_4174_8fe7_8079697b53cb
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_RNA_SOD2
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_89079e5f_235e_45ab_833b_39af0da296c5
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b256085d_661b_4445_b36a_de72b133c0e5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_406a0377_fdcc_4bb7_a168_b8d6946ce36f
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: NULL
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_178fa2ad_e957_46ac_9600_43964d5b4abb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#af9e6d39_468f_4e92_8646_fc5d0ed22cbd
value: 0.0055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b7534b3e_79bb_43f2_b218_7328ab613588
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d5359263_5b13_4596_a1de_a15667cf000d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3a312449_25d4_4e49_a99e_dafe2dfc88b2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0c17e8f6_5a9b_4744_a9b6_cf573134d9d5
value: 0.055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b939b5f2_5ce6_4adc_a892_7233b24dcd07
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1ffd47a0_9438_4f82_9907_16fba46c3dd6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bd55e103_1933_4521_8c8e_4c59fc1ae87f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_022f3684_fd9a_416a_907c_c71dc39949b7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_252a33f4_4a77_4ee3_b351_17b58d10c16e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2b9c0828_9c10_4fac_a140_24e760c5c3f2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0e51fd9d_f599_4143_8355_9602cbcc7b4b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f9069d4c_abdd_4fe8_80d3_f222f8096d42
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: cytoplasm_Foxo1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_61a20368_c415_4d7d_a659_efcc238d5dc7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_822ea0c7_c374_401c_8515_3552b59018eb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6abc0b96_5082_4e97_8a6f_7480355f4924
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c7762684_a079_4069_ba05_7cfdf6f72b08
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3cb34981_b060_4ab3_9951_fd8d7e313368
constant: true
value: 6.4E-14
name: vcellsurface
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_24cad105_d507_46d6_bff1_3375757230a0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a7aac9c2_f1e4_44c9_b6f7_b130ccd7983b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fec5e2e7_7a6e_458e_859f_726447393b9d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_176a9f05_a380_43a6_a72c_ca0c510d83b6
constant: true
value: 0.0021
name: k4prime
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1f7d8b66_586c_484b_bede_d2c45eeefa56
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_00bafb79_6c1f_48ff_a5ee_0b4fa496ec5a
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_53ca2b64_050a_4091_a0f2_c56ec454f637
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_15ed7a90_1733_4d88_9995_c55c77cfc43b
reversible: false
fast: false
name: R16f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_1c36043d_2f15_43d9_94d5_e37f76899577
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_751eff15_a886_4d93_bfd3_366dfa729824
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ad95a87f_72ab_49e3_97cc_aff9d8f23f34
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_11358670_1283_47ad_9661_3c05757b7e15
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: null
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_90a030c4_acef_4654_9fd7_ad7813780959
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c5c18727_380c_46fd_b7d9_ffafd66dab33
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_5f42f1ad_e5cb_45c6_93cc_769753bb8c21
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_45f46339_b286_4942_b39b_8081eb99c3dc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_239d2d83_8217_4e5f_8e1e_6bf7f8665faa
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4062e0a4_99c2_4581_afca_6eba1a8afe8e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_820723ff_e05b_49d4_b9bd_b025befd02dc
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Ins
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_425d05cf_9a4d_4304_85cf_70a5c26b4a56
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0b820638_7152_46b8_8430_e6db3f19e022
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#eaf7e5a9_ffc5_401c_9006_34746de93eae
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_136cf164_3ffa_4b5b_9ac5_d4e5f40118c4
constant: true
value: 1000.0
name: sc_ros
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1146431a_cfba_4d75_94b5_63ffb4c6b355
value: 2.2E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8a067e43_2dcb_4f2d_b2b0_6799601555d4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_517b9eb1_5496_4932_b031_bd8cd0a62c7d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0d2e68f0_8634_4b6f_a30a_2e3634f4c761
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_04b1eab4_0d54_4110_9cc0_75c03a6e7a56
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3e5ea443_a57a_4c69_bb84_e0c67dafae69
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4ad5fc4e_fa39_467e_b00a_6d7fb63396aa
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_526c5e08_a185_4fc9_a311_2a4d604258e0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_36fee1a4_c18d_4bfa_abcf_3a89851c5ca8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_382c2d64_0a33_4275_8249_3a6c6bf90192
type: Reaction
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_3607bd06_1e80_4187_8a06_829979fca4b4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_25b91433_369b_4d0f_a85d_8fa5ca021159
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: Foxo1_all
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#a9e10611_947c_49b4_b539_366c49a1d405
fast: false
reversible: false
name: R35f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#db82ed22_7f50_49e7_a3ec_3513265c48c9
value: 1.81818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9e672443_2dbf_4ad9_9645_a59bc02f5f7f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e4afc1f8_1a35_4c0a_84ec_e07d61f0ad62
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_293d0b60_b85d_4d08_84c1_592206b0cc92
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a134def2_55da_43b4_97e9_fe221eabfe46
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_280a732b_a2ae_459a_8af9_e645091bca01
type: Reaction
reversible: false
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#beb8a2a2_4391_427c_aca8_32bb1c52ac76
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_09cc5272_8b22_48c9_83d6_4afdda0bd084
constant: true
value: 2.0E-5
name: k34f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4ba89093_f978_473c_8d9b_0d5dfd0db6d6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f070396_a1b8_44c7_a04c_6d0e20664931
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e343001a_7c3a_48de_8a0f_6a34b9cbc35e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bc477134_46c0_4cb9_90a2_def5b3047c15
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7191db24_9a6d_4fb7_a3fa_40e2392125d5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5263adc2_7f5f_4cbf_8f21_ecbbf53fadd9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2dcd0117_e7eb_4c0b_aeaa_2250106eab62
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: IRS1_TyrP_PolySerP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#ceda0d24_fb73_444a_97fe_923fb3dc3396
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5f212be4_acf2_4774_8507_4323fc97de6f
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f8b960d5_127a_4861_b645_9519d5919c0a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b5dbf877_cd04_4004_b74f_183f47112d1f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c3c3934e_3b0b_41b1_8ceb_8c7884bb068e
name: degradation of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_1c1cbf7d_a820_4720_a98b_3790b8692f33
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c4276a2_445e_4e02_a1aa_f84abb000a49
constant: true
value: 2.8E-6
name: kminus7b
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9503f054_e48d_410a_b4f3_baa3cb3afaf5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6af9b99e_1152_4d89_8dd7_fc5f6e851faa
constant: true
value: 0.002
name: k31r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6226ea26_77c4_4a97_a841_3000017fb3b5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_184a6e11_84e7_4541_bdc0_6757e56ce831
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4af0c2db_c77d_4bc9_8988_a5e8944c2319
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dafa1a33_58cf_4fb8_8233_cd01ced5b539
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3478f4e2_5aed_4272_acd0_b995d09604e2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e4302200_f78a_429a_a7ad_bba43f63caa7
value: 5.622
name: kmdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0b5495a9_bdd2_45e0_81db_eb1767a331d5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f360aed5_3976_4a2f_a15d_c6229fe74dc4
fast: false
reversible: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#ab9902b1_8b23_42c6_8c26_6a0756344399
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_97fe7ddb_50ec_47e3_a85d_f78ed0a4e862
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_81f3c389_2263_4665_b6b7_9d7a3dd8c314
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1d70f6f3_4665_44ca_b131_57b717f2ae55
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e2c8ed0d_8098_42ee_bb11_0ab807228d26
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aa0ce821_fca2_4edd_8766_e2a973fa8cc5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ec548be6_bb25_49f0_9fd1_e17ae14da7b7
constant: true
value: 0.87
name: kcat51
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f9cb2336_2703_47e7_bb3b_5e060b7b5ddb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ffef6b2c_f69c_454f_9267_e271906474f8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_89de2abd_e2ba_43ec_b86a_5bc2943fea34
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ffa513a9_b11d_468a_a0c8_b26d13636065
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b574290_93ff_403b_ba54_79a000bde1ff
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b04e0ac_fafd_48d9_bbe6_be50986a23f3
name: R16a_f
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_532feeab_d3e7_475f_bb4e_0ec3f419d282
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8486a115_7d35_4b0b_a43d_0fe4b15b12ce
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_1dc17c0b_57be_457c_a7a1_9b419d27c1f3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_876785f0_f772_4973_9168_dcc4bec079ce
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_96de779b_3845_4331_9900_40552035a4e3
type: Reaction
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#ce3044ff_041f_489e_8f0d_eb54bea22b02
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_34d47f19_b409_419e_81e1_99d6ab931f34
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_5e240c80_55c3_4a0b_a870_9d5c1a030c37
constant: true
value: 0.001
name: k34r3
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c7ecf96d_a455_4101_86cc_da8571f13ffd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8343d8a9_58a1_423a_80d2_04edfd5f450e
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_68b6bf95_1c81_430c_b5e7_8002eb2e4786
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_30975ac7_fec9_4a6a_a103_f38d08b1781e
constant: true
value: 5.0E-7
name: k42r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2c1bd84c_e9fe_4dac_9c85_e463ac188ebe
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_986bc745_738b_4fa6_b13a_d706a4966d64
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1a5e1faf_cd1e_42a4_b958_0e4ba0e3efa4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cd636102_b54a_4b96_b8ce_c78e5947efc1
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_90ef2ce9_2375_4253_8a12_08c9fc79fb6a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_09de9898_f394_4999_a801_cd9e37cb9dce
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2cfa08ca_f034_4ada_acde_f7d69bb4bd9a
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ff2687e7_3b84_4fa8_a67a_8d21ecd63602
type: Reaction
reversible: false
name: R32f
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_1d40b741_7b61_47a5_bd59_acc072a36b8d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_551e17e3_4e81_45ef_9fa8_5d38264677fa
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 41700.0
name: cytoplasm_SOD2
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#bf67eeff_8fdd_405f_8803_f00c643fc7c8
type: Reaction
fast: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#ccf91612_06ca_4532_9cef_61f30dd2d3bc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1152b192_92ea_4246_89f6_ed22707ab112
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0824575d_8837_4362_8af4_cf843f60be0e
value: 2.2E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b0c38fbc_f65c_4898_bd79_dd8e8d54813e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f83afb6f_616c_497a_af3e_91aebcefdc88
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_70e3a3a7_ac03_40f5_bd6c_c64b2a343ecb
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_428d7fd1_6269_4e6e_9592_7444f98ea68c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2030b1a4_fc4c_4bea_bf93_6d91c1c2d11f
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3a22465d_693f_42a3_b897_4110766b284e
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: IRS1_PolySerP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#e9caf93f_92ba_474e_83bd_5ebda7ee8012
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_265ed746_64ad_46a1_a1dd_70b6a75b34d9
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_77712d90_c949_4670_a650_4f04230eef4e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_56e5797b_7527_4369_8c0e_cdfe9c88993e
value: 0.55
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a6e1a147_0eb2_431b_8623_e86daeb70d02
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ef613765_d5b9_416b_b33f_ce72624af021
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 2.0E8
name: PIP2_mol
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#fe0dc565_4c7e_49b3_a339_0b32d36327a7
value: 0.55
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1ce4533c_c953_45b7_9d31_78880ed3d7ca
reversible: false
fast: false
type: Reaction
name: R31f

http://identifiers.org/biomodels.db/BIOMD0000000474#_66e272f8_7d42_48f9_a01c_a373f787591f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_294c9b5f_e80b_4d6e_a874_70147679eb09
fast: false
reversible: false
name: R37f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2bb25bd1_973d_4ed7_a3fb_ed8b3173fd79
fast: false
type: Reaction
reversible: false
name: R51f

http://identifiers.org/biomodels.db/BIOMD0000000474#_06704924_c3d8_41b2_8557_5c585a3e62a0
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3754f6fa_a119_4db7_ba78_6215818d28b6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9140409c_f7fa_4b58_87c6_eb4d2b8e60d3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6382ea3f_4ae3_4037_a8bc_c80e5498c7f1
fast: false
reversible: false
name: R50f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#f4ed8ca9_ff41_4bf5_b687_fa5065f116a6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aeba5f97_de41_46ce_869f_ed76164e2eba
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3ede3c26_a08e_4407_832b_3e59bdb7ad99
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9f4bee58_8957_48d2_85c6_db4449eb9174
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_416bb85a_0fb6_4e6a_961f_7cb44b245ea0
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2cb5658a_94a5_4ab8_8597_18912c70cb64
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b41bd39b_3d72_4a54_8c0e_58b45f0f5e1c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#adb9f83f_5e1f_45ce_9739_ac933a6fd7da
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_75ae5d48_3f70_4d92_bf60_490dd93f92ea
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#df96ce67_c509_4239_96f2_fda4c677da22
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_25719b6a_9142_4a16_943b_613817a82827
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f7417921_a0c2_4328_a31f_012f03a58adb
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ef52351d_ead8_42ba_9740_9ff0f2c633b1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_984b9c2d_d259_4a43_8666_834b733a9c85
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_033f13e0_865e_4d38_ac0f_2d0d28ca9889
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: DUSP_ox
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_3a24128c_7274_4699_a065_f068d729324a
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#a046a84c_7d0e_4232_a7ae_8dca12b5c817
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fe8dd318_dcfe_4251_a1f6_c6e9784658a8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_86ddab44_4713_4e6e_9ad5_1bb5075e059b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bfe22902_de17_45d7_9338_0266a487e7fd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3cdad9fc_e993_4b3d_a7f5_97ba22d1a0a9
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_01085d69_c02d_40df_a98a_858b6ac6a9d6
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6e93504d_5b80_46c1_8743_4b59e6c36757
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4e6cfcd2_ae1b_4683_9d0a_37e9c602f10b
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#abee53a7_a0e7_4dd7_99b9_11bc83c2ce22
fast: false
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK

http://identifiers.org/biomodels.db/BIOMD0000000474#_196186d6_fa5a_4849_95d0_72cfec349f78
name: R43f
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d6a58c78_638b_40d0_9bb3_c2b66794e8a1
fast: false
reversible: false
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_056ed76a_8b0a_4e05_838b_d4267eb1e5e9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_066ee1d5_dcdc_486f_ab60_9e7e9f5eef13
constant: true
value: 0.001155
name: kminus14
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c1a582b9_8225_4bb4_a1d3_a956da8791b7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a2b170d8_132b_451b_910c_e0b2b7d9f554
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_64051a5d_1be7_499b_89fd_6bd3e0b6a037
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f01fcb8_aab0_4681_9989_349e0a4160bd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6ea8a8fb_78fa_41ac_adbc_3d60a5d573c4
constant: true
value: 5.0
name: alpha_ox
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_968a35fb_6e8b_4eec_9f55_693ed14cd4af
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_230c86a6_36e1_4f5d_bc6b_2be8d97242e1
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6bcba9dd_30bc_4414_be66_19a2e47985bf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7d752c93_2e34_447e_8046_8e596e7ac8f2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8da5fc71_a257_47ee_8a18_bd29b7744b3c
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_824b709e_5cb4_47af_8d3b_85e85c386e3c
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_40dbc851_0cb0_454e_b55d_664b1cbd045e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_08d57921_f592_407b_9c41_9514f61f3bc3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_56719f3d_5319_4c25_96d3_4479d9fae07b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7eb5cc47_fa34_494f_8861_bdc2d1625ace
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_425fdd46_02a7_4ee2_8ace_de1f51834223
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8ddd23f0_4765_4efd_b447_005e33653e7c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d136eefe_113c_4679_adf5_9724b5a66b51
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_111ac243_b96d_440b_ba0d_60bb73e1a893
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_48ef31ce_6a30_4740_9e75_4ffdd2db48d6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_66e51378_0898_47c3_bdce_03b5116720b5
reversible: false
type: Reaction
fast: false
name: R12r

http://identifiers.org/biomodels.db/BIOMD0000000474#_7516a036_522c_49ce_b0c2_8006ed2b0539
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cc00b232_4f84_4951_8662_30e5a1a0322d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_587b85dc_8a99_4654_a0c5_a9436a06aded
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a4680e74_f233_476d_8a2a_1b6375c6c900
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0348340e_6baa_4199_a8f6_8f738cab42cf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3cef6207_2148_42f7_919f_4e9a7728fbc9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7aad49a3_6ee8_41ab_a812_2d7c973197f7
type: Reaction
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_1779d4e6_330a_43a9_9f8b_e080c8855e77
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b9f1287_cf18_4677_8226_4365097e6ba3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ad523996_147b_4220_b552_1f662c9a1526
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b169411d_2447_4996_98ec_bf51c443a8ea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2004baa0_2f99_4302_8d6e_f40c493e38d4
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: PTP1B_plus_PTP1B_ox
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_90b79a39_811e_4356_87d1_dd50c69344fc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0b989058_f52c_406a_8dc3_57759a9e7ae1
fast: false
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_4de5417f_bac7_4b75_920d_965b98c89f4f
constant: true
value: 0.3
name: kminus4
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_654b4c06_cb71_407b_9a60_5857bc68a0e8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2a4a85c8_1b3f_4145_9779_1b9fd27d5abb
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0d4c5d79_a979_48d6_8541_d95aa9177916
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_13abf711_a27c_43b3_8c22_1686b40a563b
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8442b78e_b0b1_47de_b54b_bcefefd666ea
type: Reaction
reversible: false
name: R10
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_2f2da6fc_81fc_4058_b5ea_6082cef28f3d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2435faa6_1dbc_43e1_875d_ecc144866608
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e483ab33_196b_4f36_8e2c_9aef12dc08b5
fast: false
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#e23e9fb6_45fb_4ece_8f89_47301c6ce968
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_736174ab_3b8b_4365_a0c5_77e238d6f4c1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b8fd210d_3690_4783_8a12_609e8b516c79
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c12827eb_370a_461c_8089_3cab2f51ecca
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#da7a43a3_b737_4ea8_929f_18587019d328
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0a9d0886_c7f5_4f2d_9c2c_a3bb7f8e327e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_01dd3bdf_f204_4624_b2bc_908ada59635a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ba4c4036_c836_4fb2_804c_2a84b07e2728
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9b4df7ea_ae9c_423d_bf87_bcbf3be8b198
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_87825a0a_98e9_4f92_935f_1963b62186d5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_743cc0a3_9c57_42a6_947a_43e0b2eada52
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_69707116_c8c1_438d_93aa_8e28387c46eb
constant: true
value: 200.0
name: pip3_basal
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9f814d87_9e6a_4fbe_ba3f_41a3640234fb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aa478092_d2b9_42d6_ab1d_8cbdf59ff209
name: R14f
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#cc7929e8_16b4_4773_90a1_a1f21e3107f0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b5729640_d8de_4490_a10e_536891f3efed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a5f87f65_f66e_4978_81df_af37632439d4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: E3
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#c021ab4e_b441_491d_847c_71085f51f950
fast: false
reversible: false
name: R38r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#aef9ac19_4634_4518_9499_8e00037984ec
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9a98ffe7_8926_4960_8951_ce327b2cde00
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#adbad9c4_cf94_4e8d_8977_d512a8ba7d36
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2e507210_6f9c_4b4b_ad0b_8b2c33ec61e9
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_70a2decb_6dac_4004_b497_aa4db755df1c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_78038800_2e64_41c1_a8c5_1098c9e3aff6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c56cd775_4e52_4b4e_a3e0_425118d5b0df
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8de3afa2_0252_473e_abb6_691fc59cdc81
value: 6.6E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a9df211_ac64_42eb_998f_8aeb7fd25da1
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f3896e8e_20f4_4084_b778_72686a0e5f9c
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_7258c8cf_da7d_4741_94ab_fe516e1f0bbb
reversible: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e657c6b5_9f88_4738_88ff_043aed63ceb2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2a0e533b_6067_4ff2_9656_16708a95677a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_16fcb67a_53f1_4f38_81ce_177268f18f98
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#da8944db_1e5f_4639_aff2_45f2bb66d3f3
constant: true
value: 4.61E-6
name: k6
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_021a47ec_966f_4205_8db4_26cdeea1b778
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_910e6dbd_ba9a_4999_8d9b_cefad22d7922
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cf9331d3_9ef1_4fbe_bd4f_f4c1902fd734
type: Reaction
name: R4
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e755c5c8_4374_4fcf_ac1f_24ffcb03fcc4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_08335fdb_4e90_472c_8011_acba6ae6afba
fast: false
reversible: false
name: R34r2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c02b7a6b_c0f3_4edf_9cf9_27bba50311a6
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5c1326bc_03c3_4be7_b95a_c660ddb617cd
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c26de4c2_0323_41aa_8944_431a3dd31c45
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5ac10270_658e_4dbf_8239_a1ea89b34621
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3320679d_ea8f_4e06_bc16_7ba92bb9add6
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b1b5850d_6457_40c7_b2cb_36b2fdaa71bd
type: Reaction
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e8ef2e6f_21b3_4418_bd75_bce0a29fedb6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_358f59df_a9d6_480f_8187_96f7f54dee0b
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_536370f5_18be_42e6_aaec_6777959c0abd
fast: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_6c0819b6_31e5_4046_82df_58eae40bcc3e
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#d6d115f7_8c8f_4e32_b8eb_423897c3198d
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f83059cf_8077_4de3_89e5_dc596ee1db87
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#db104cd8_5f0f_4726_a277_0364b7f7e652
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f119e160_73df_4b87_8beb_307189e40d4b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ecf7165f_f7f2_4a1b_8f4f_971e0877b727
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_11342705_575c_49f6_add3_c0f33ae1ce03
reversible: false
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c9c9345_d783_4d5f_9fbb_3ee6f7ba87dc
constant: true
value: 2.0E-6
name: kminus3
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_45dae5e2_484a_4b84_9c11_f6b3642711e9
constant: true
value: 2500.0
name: k3
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9bef4620_595b_492c_b74e_3461949d3217
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#ece97232_47c5_41d0_af64_14513021dda4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cd383519_3fb6_4189_b882_d1e7196d96dd
value: 6.6E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a43ee61_8e4a_4705_ad0d_b2729fac553e
value: 2.46
name: ktransl
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ee9794c5_8866_43bf_ba72_40ac51bbbb96
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4df0114b_aac9_47bc_9717_ba6d32e0f63b
name: R12_a_r
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#bc9ae8f5_5dd3_4f0a_b429_26470de3140f
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_4f20c93a_77ab_4b3c_aef9_d43b348ee3ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3e2736a6_edb9_4ed0_b93b_286c1bcd8340
value: 0.055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_147879bf_5e66_4c54_81df_6baf90614d92
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3775762e_d1fa_4eb8_b786_09b894ecd49d
fast: false
reversible: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_86774300_d2e1_4b53_bf5d_efe37e88fee9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_9468bc4b_89a4_4bdc_a2fc_d18376f2961f
fast: false
reversible: false
name: R5r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_649d5c29_ab4c_423b_81c5_6ae69a4814ca
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9817a272_2669_4139_b0af_119c87fc8744
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_33078060_bee2_4354_a5d5_4fe2de0d5d4b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_69459d0b_0795_467a_a5ea_143a695274d2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 20000.0
name: AS160
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#cc47c837_bd99_4cfb_b8be_51075d3a7f53
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#b13fc457_6598_42cb_908f_45f2ca6279a5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ea8c267a_48eb_40aa_aae2_e900d088de38
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b1543620_8a4d_4d6c_80d6_cf0392ac7fa5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0743a56f_b735_4e0a_b112_7607a8fa3055
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_851033f8_8466_414d_87ce_f319e1a3d27f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cc534b62_a12a_471a_84ac_f4d0726866c2
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_92ece6a7_d3ac_4cc4_8e2b_669ebc61e6f7
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Foxo1_Pe1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_91e034b5_fe9f_435d_8bed_0e92634ce156
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_69c553a4_e835_4f35_b345_fcd34f50690a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1ba56c88_cf36_49b1_87f5_f3a808200bf8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b3b31d15_7c0b_4c67_b46c_9266fe73d4bb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6d861a50_5412_4e34_9d8d_e5d82e5990b7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_29b59ce8_8274_4e5a_a8ae_31130be88b19
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#a23b4cc9_883e_4a5b_83b4_945a9a47b262
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_468fd397_4334_4ce6_88a4_82ce5e9b89e1
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: Foxo1_Pe0_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_08f04554_1d4d_4e3e_85ff_62e38a227654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#c3ab6f81_e002_41d7_9330_1f1371b1932b
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e13f9e73_db3f_45ed_87f1_a2cf1ce3c7c0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#ed910ba9_fcbd_4fe7_8792_ff866e2f6434
fast: false
reversible: false
name: R37r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6e2c70d0_bf8d_4d7e_9d81_340240e458a5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e9715b12_dbda_4dc8_b17a_9e56c589fad0
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_9c684a9f_3daa_4ebc_bee7_e7d0400760dd
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9aeb81bb_3401_4f79_95d2_a55c32424d0d
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#f515d314_290f_46ad_95d3_d76c77889f60
constant: true
value: 1.25E-6
name: kminus12
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_37960d47_e066_4ab9_94a3_2f72dadc788c
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_90b67553_1214_4627_a54f_6f15bcf636e3
constant: true
value: 0.0055
name: k9
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2d7d1b9d_eb95_422d_9949_573c6348cf8a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4f67ebf6_e655_4bef_9765_a1805809158b
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#cca89a64_5853_4a38_85db_cba9c2c00311
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_41fdb469_a930_412e_aace_29b48bea858f
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: PTP1B_ox
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_7c5b53c3_89d8_40a4_9b7b_29573debf056
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1381fa19_8833_42e3_9e21_2767b02eacb7
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#bacf651c_1da3_44fa_8dac_a77a977bc35c
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0d72bf3c_9d5c_4084_94ac_7ff192a28d6f
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#faba9a13_fe31_446c_8117_75068e934f5d
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_204163f2_fd4e_4ac9_bd4f_3aee1884b94a
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_32c60a00_528f_4318_be07_1b772ecbfce3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_32848528_9b14_4121_a37c_cc300044f02f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ca327365_0857_4287_9a38_2f7a19d7231c
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_5d0306e3_a7de_4b86_a276_9ae7bad998ff
constant: true
value: 6.02E23
name: navo
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#fafc3bdd_680c_4e73_8144_df875dc66afa
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1b5d1456_8b79_4cd4_a03c_0a29ad480284
value: 2.2E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_16faf939_de56_4bd2_9997_7bf2a19ec9b3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_35329691_3134_4c44_a35a_d39cc86a1718
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d89d86ab_6e30_4410_84c3_cb4fb6356bfe
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f6a43f5e_3631_4a00_83bb_f3b091e9041e
fast: false
reversible: false
name: R13r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_9169822f_9857_473e_a1cb_d7cd5040fa10
value: 0.909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9ab6dc31_04e5_42e0_8204_87a5f48cd72c
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5ffa5d47_25f6_4698_8f6e_e0d18192315b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3e0a2b96_89d3_461c_b98f_a9de1291ebaa
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_056ad395_418d_4988_a0d2_dc34672b6793
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_579e2c23_5a33_433b_9ed9_8c3db2bc6ded
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d8081ba5_7162_477a_8e6a_add01bf7cce6
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a83992e_dcd3_49bd_b67f_26020d0d50ea
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_399fc3bc_541f_4688_8da5_b8b9941a258e
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_77350e14_3714_4c46_841c_b9bbdbe33d7d
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4136a820_bd7a_452b_b99f_76fe76a1ffc9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d03a35c8_d47c_4a11_aab0_9416f5a3eec0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: PI345P3
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d9751435_48ea_4577_aca9_55bd3643c351
constant: true
value: 2.7
name: kminus9_basal
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d391e8d0_a0f2_4626_9c70_e89ffc332c23
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_04f43d0d_d7df_43a0_b9d5_8bbf6ec9a197
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3e63d53f_9910_4b23_90da_5a970a6b3245
name: R17f
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#b84e20dd_a0d8_4b3f_96b4_bcb372828201
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e167cdd0_4119_4830_935e_0fc557484cbb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#afcd64e8_ef53_414a_9b06_165bdce21cf9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4f3df3e0_ebd4_4e73_beb2_e65f805f1b29
value: 5.0
name: v
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#aba13f9c_10a9_4eff_bdce_e0f439720766
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_609fded7_4689_4439_89c9_f711d5ccc725
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#dfa4b082_6709_4d11_98e6_8da0d09bfe06
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e59b6ef2_5e64_482c_980f_d72cb9849ab6
reversible: false
fast: false
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_0c280d40_96ad_471c_b137_5706dd0d69b7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a60ed2a8_0601_48fe_b1c2_439792961b08
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d49c05b6_40e6_4b84_9f34_49a08c97bd80
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_750e559e_df54_4d41_bc5c_42decec2f5df
type: Reaction
reversible: false
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_2c084f36_1170_460f_ad41_97e85dc9337f
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#cee4085e_b110_429b_a013_c9ff07383ad2
value: 0.055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_02a575db_9e24_4e9e_af01_645b9067c0ec
fast: false
reversible: false
name: R50r3
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_99af45de_d68e_4a66_8cdd_2ef72a2a7284
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aabe8564_0c48_4978_a5e7_af67fea66fa5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1abcd60c_d206_487b_841f_daeb0207b3f9
constant: true
value: 1.1878E-6
name: kminus11
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_56680bb3_5e3e_4afc_9de1_d3ae06c02abb
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_05058355_02a9_41e9_865a_e03288c88863
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2f8fb59d_f300_4c1f_aea8_0ef9f05a196f
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8d4f264b_0b04_44c0_86b7_c11485ce404e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_09744811_99f6_4d17_a2fa_da92581f0a2c
constant: true
value: 0.167
name: kminus13
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7e6389c7_8a72_482e_987a_5776385592f7
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_370652cb_49e1_4385_ad57_252d0d363565
constant: true
value: 1.55
name: kminus8
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3221d09e_bbb4_4612_b91e_ef1934884b23
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_21882f1c_712b_4cf5_bee5_16df06fd4410
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3d2ca13d_688a_4944_8b5f_e0213245ee91
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5486af58_e586_41fb_8ff8_38f0d11ba009
value: 5.622
name: kmdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1f1ae4d4_a0f8_447c_8d29_2e873361b75b
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_04570f8c_fc30_4b69_be9a_42287bcfd788
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9cd74853_f58a_497e_ab5c_44ce4f624ac8
value: 0.0019
name: kpdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c11fece9_7505_4477_a5b5_c636610572dc
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#a2aa9a5a_88d7_435a_918e_c1d536b6dbf2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_452324e0_b75a_4f8e_b2f2_7079a7d00944
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_29d363d7_b0f9_4403_a214_b7661e325efc
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#db6a09a9_c34c_4435_af0d_f495cdc18ff1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9c5d8e4b_c181_4000_a963_8ba0d23e10e7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_RNA_InR
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_2684dfa6_ccf5_4e0a_88ba_891e6777fdd2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_810aceda_e3c7_4321_87a4_2361e3d3218a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0bc0e48b_1c3f_4c54_bd93_c3d1fa53d33d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6a512688_b906_4eec_b845_c1af599de0c2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f3b3cfd6_ad4a_421b_9d87_150fa52a979e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_559ed1c5_7d17_44f3_a04c_f0b6d3297ded
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Ins_InR_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#c1bed0f3_57a4_44c8_9f12_eb562259fc7d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3d53ca87_d4cf_4d68_a5e4_0256fc23f928
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#edfdf4f6_23f0_4a18_a6ef_056f85cff03e
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 50.0
name: Mt
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_61534039_9979_4aa7_937c_6198754f212a
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: AMPK
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_70cfa8e5_8e06_442a_b39a_6b19f8356df6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cdbe0f51_702c_4734_a629_be65caacbcbe
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#fa883064_3500_4f64_a6b4_4cf24130b1fe
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e0d89cd1_c859_4782_8485_a55fa4899736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10000.0
name: cytoplasm_InR
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_89780a67_840e_4996_855f_ddff2423e056
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ce7d7938_23a1_4bed_b55d_b39767aedbcd
fast: false
reversible: false
type: Reaction
name: R12_b_f

http://identifiers.org/biomodels.db/BIOMD0000000474#d28bc5d7_73a0_4962_a29b_b5b4370b1349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_96a536c3_5820_49bd_a7f6_c832a4dfb8b0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_82e7c619_1118_4955_8046_086e774379ad
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ed119519_64d5_468f_abaf_0224ef7bd095
value: 0.0055
name: ksynth
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d8b2c954_9a49_4634_9220_15ac4892748d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#de8e1d33_b262_4976_b9ce_735ed8aedc1e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c8f31301_ce5e_41a8_95b4_ed061c884b41
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fae4d42f_17f2_4e38_9070_a871a8708b9b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_18d02d40_7e73_46a3_9b2f_f64cb1c2afb8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fa3a91b0_1a2a_45f8_9157_ad7e3759b8bf
fast: false
reversible: false
name: R1r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_1aea1a77_b658_477a_a2d4_c1a0327d7d2e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f57643e5_a962_4467_8f59_b5e076e410bf
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f1cac390_0a8d_4f4c_b173_250a7aa9ed82
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#c28f1a2e_c275_424b_a559_d517df4ca742
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b49efadb_2703_422a_beb8_f54e50ea5b4a
value: 0.00909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e4e87630_a033_46e5_b115_90e5476f7694
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_97e33073_18b5_4ef5_9623_0828cb9bac3e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aa035d10_8bb7_435b_a98a_121000f866fc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b0124673_369d_40a1_bde8_d1aaa1da5469
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5044a5c2_fd95_41a3_af2b_cfaa080aed07
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3152c749_bd1b_435c_bb69_ddd028c43d41
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#eda56e43_ac17_42d3_8c82_6c0724b89c70
reversible: false
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#_44136373_2bc1_47d3_a5d9_26f7d5f64080
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9f358dfc_ba73_49e0_a882_046dc63f5427
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fb465193_9242_47a7_8393_d061cbd8f20a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_85b71e8a_b6f9_4182_84d1_e2f609fef204
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dcd7dfd1_0fd6_4f09_b67e_0c18fc3b54e8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_75741ff0_8980_43c7_bbb5_5e1e1920d96a
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

http://identifiers.org/biomodels.db/BIOMD0000000474#_736ecd1e_e0d8_4e53_b0bd_4123ad235915
constant: true
value: 2.0
name: k38r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0e32336c_3fdb_4207_a1b0_4b79dc2dc4c7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8fa5b1ec_52a0_4624_a47b_4b29b507e2a5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1d4df99f_469c_4106_b142_abd4b700159a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fb6ef74b_c4bf_4320_abaa_9f98964c9f3b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_371c32ac_4a69_4f9f_9ce1_a619aa47b508
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Foxo1_Pd1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_8fbfdcba_0529_4ba5_98e1_084e89a759ef
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8d4f3475_5944_46e1_b469_5390fd26d18f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b5bee475_f44b_4aa4_b2ca_c52769042271
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8269f313_67b1_4215_8352_07617ffac6be
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_00e4bf33_c409_4ec1_afe3_e6a081c5613e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f0da7331_a0e9_4765_aba2_ca83a9fa8fe6
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_38d1bf73_f912_4b21_be83_d07cd681d550
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_34ef7d13_4956_4a05_a6e6_bbdc1760b0dc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8ee27abd_bbc3_4bbc_ab7f_4b5a5aa97ed1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a86be315_2425_4f82_a220_44cd6f1d168c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_00ac4a9b_76fc_490c_9877_7c1579157a41
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b211b072_23b4_4629_a1c5_f1653e31634b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#db6459f7_2227_4b14_8bf1_3807c78c06a0
constant: true
value: 0.05
name: k38f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a48e402b_6fe6_42df_b929_a3adeed255f7
reversible: false
name: R38f
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#a52b541f_1947_4e15_8105_49e738880515
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7f1b3694_81db_499b_a2fa_9ed5b5b83bff
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_5853b023_1747_4ba2_8d5d_7dfcb3682643
value: 0.181818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_460707e6_478e_4f77_a555_7917508b87c9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bac45ce4_9ad7_4257_b7d4_3982dbeb1151
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f39ee76_62b5_4a78_85b2_a590cd7a4e7f
fast: false
reversible: false
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_88ffa7a5_2c3d_4593_983e_b4f4b9f435a2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#fc957752_e503_4fa9_95a3_cbc1163c77da
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#f76e5f34_ab72_4949_b05a_0e66d2cb6428
type: Reaction
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1

http://identifiers.org/biomodels.db/BIOMD0000000474#d775feeb_caf7_4ec4_a5d8_74f47feddb9d
constant: false
value: 0.0
name: rosconc
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2e6f346c_522d_4e87_8379_22446a6b0bbf
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1b8725b3_e702_4ab8_906b_ede3111ea5e2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_886f7e48_09a4_4f41_a5d3_58a1e34c1324
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_046b72a4_93ec_464f_8830_b42794bf695b
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_99901a4e_6e0e_4c84_aa5b_b6acfdfc50f8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_36466f77_5da9_494d_a5b6_665fbee10ff2
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_85662424_1e10_4213_9225_02cae22d90e5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_505cb89b_dd72_4048_a3cd_0f4f03e5dcea
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e3ecb207_45a1_4018_bb47_887262857113
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b09f9b0_1205_46c1_8346_773435c57925
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b98b06d_6fc9_4d5e_b553_2bf7447bf6a2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_452155dd_1689_4077_b859_b4791b21f9d3
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#cd4eb43b_a140_4608_ab69_1671cb37cd48
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#de17acff_923e_42b7_a56a_55dcbf952789
fast: false
type: Reaction
reversible: false
name: R12f

http://identifiers.org/biomodels.db/BIOMD0000000474#cfa0c72f_eaa9_45fb_9a37_8f748c2cdb64
constant: true
value: 1.2E-5
name: k2
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c5ee02a9_fd94_4ef8_aa55_8e5e14a4f2d6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_95e73c76_22b0_497b_807f_8846b7c6784e
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Foxo1_pUb1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_27ef62f2_f1a5_4941_b04b_1d05f6e153dd
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7ffabcdd_e2dd_4653_8836_a2decac8b0f9
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bee7c47b_591e_4fbe_91d2_e170f464989c
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e7fbb761_b0ff_4210_93e2_260748d9fb7b
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_48a163ab_9cb9_43dc_ae4f_807235dc7fe1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bd4c7f54_3f4f_4f46_a208_b97a1693372f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_83f4a14e_84eb_44ad_8e82_c4baedde19f7
value: 2.2E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#feb107f7_b600_4591_b36b_4415077f7972
fast: false
reversible: false
name: basal transcription of InR
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0beab129_1b8a_441d_b74d_555ccdd94ce9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#edc27564_dd01_4ad0_97d1_59b0589b1c57
value: 0.22
name: kexp
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_78d6905a_5ad3_444b_8bad_9d445333668c
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f1c4774f_f541_4cce_a71c_86f9856e15ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_194f6996_3787_4fc7_bf1f_dcaf26c592aa
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_10f0620b_193a_43de_b804_fe83206c7d8a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8c6592a7_1e2a_493a_ae86_d82e292d75ff
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_340d4d47_e940_405f_8860_bdc829bc4125
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_20e0b499_f8f3_4a10_8890_227b2292774c
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_98d536b9_014c_4573_89ac_ef12f53f1262
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_39a5387c_7cc1_43c1_9346_14b0190ee1c0
constant: true
value: 6.02E8
name: molec_per_fm
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3a75c8fb_6ad3_4f7d_9cf2_0c3da0e6a11f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fcbc10b7_199b_442a_9818_ea7474c01f4c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_99194165_6fa5_468e_9fc6_a4e0927a35dc
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_5380d7fb_c06c_4564_a509_2df34bcd4b3b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f65ce1be_c472_413b_8fb0_e333825a91f3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_171507d2_05cd_434c_ba4b_462597d59de9
value: 0.0909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d8e0099d_b0d6_42f7_b889_55f95b610ec6
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4235f806_ba0e_4cbc_9c9d_2f89c47a176f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4b43d092_2315_40ae_ab1e_b95eb57d5924
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_64bd0669_7dde_4b45_9914_885d1413479e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6f1c952a_b17e_498e_b797_7e247bf9ee54
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_33c764a6_3a3f_4ef0_8617_010e61aaadc6
constant: true
size: 8.3E-12
spatial dimensions: 3.0
name: extracellular
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000474#db894323_a162_4bc8_b141_23a3b074944c
value: 0.0044
name: kpdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1f354c35_6247_428d_998f_293fb9463527
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_951c0fdc_413b_439e_b2ad_af0146f396bb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_08f29678_3f15_4f08_9134_0acdf0ba4da0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f66fb933_1e84_45c0_bbe2_39fdaad73470
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_550f7c7d_0edc_46d8_a367_1bd06cbe2d84
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6d3c6e2d_b72c_471c_a4bd_cde895c7dd0a
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_35bf8941_caa7_4182_a499_37f83440bda0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#eeed3a54_9d62_4218_9eac_05fd5b67cb36
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ffb7d53d_ef00_4d1f_93af_2fd95bfdfbbb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_60580aae_8fd8_419c_9f84_1b37f313df6e
fast: false
name: degradation of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c3d9b2e_a1de_4f6b_8478_11c2b08d0950
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9d486720_bf2a_4e82_8fb9_e4c1e3249397
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bf65098d_e085_4f94_8d97_2944747b86f1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a93e423d_d629_4b43_a4e7_78c4b692ed7e
constant: true
value: 2.1E-4
name: kminus4prime
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9a962738_72bf_4261_9773_1cd5c80aa390
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 200000.0
name: PIP2
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#ee58c595_a866_4eb3_a881_40e486ef5f62
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_48ddbb43_6794_4ef1_b270_2f4bf51081d6
fast: false
reversible: false
name: cyto degr of SOD2 RNA
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#fa83560e_e8d2_43b2_85ba_515319cec6d2
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_818a2d9a_f4a7_48ad_be5e_0a8ae29da104
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#be7e31eb_fedc_4be8_9707_f188a1bd1206
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_142194c1_cf55_48f2_8204_c3b1c9efa5ca
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f992e83c_72ac_4f1d_aa98_739d2d5796a3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#af7a9010_416c_4670_8d06_6388945e8123
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c45f8fe9_2ed7_49e6_8581_6107e56eebf5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_146f21ca_c025_4e4b_a9b5_d0035f6fff9a
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_613497f5_af8f_464d_abdd_8b07093428fb
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_873dadf0_4891_4bfc_9ada_32ba9eec28a5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_32dae372_8347_427f_880a_c76d79f9b8ed
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8da034c5_cdbc_4628_bd21_20c96de924b5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6da4713a_d6a4_4523_9724_8a6a8f93e278
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_24d730e6_cc22_4d34_a6a1_7b4cce4a49de
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6016fdcf_f47c_4eec_904d_de2e35753ed5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: Akt
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_59bbeae5_69d1_4d2f_8d69_3398cbdc7686
type: Reaction
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_688f1824_4621_40f5_b23d_ec141c6af47e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_725a5142_9442_4c37_908f_aeea73cdae7d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ae9cdbca_abcb_4eb8_bf66_5173112dce7d
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a22cc851_3ab8_40de_8879_7005e0580e65
reversible: false
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#e4a3c8c7_133f_422d_b2cf_b7f62de322d9
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: PKC
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_2064c010_bd38_4a68_8521_c2743ad09380
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_60ab621b_e82b_425f_a002_7d04bc54a4cb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d97240a8_3044_4976_845f_7a0e86f71f3f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1650ee9c_048f_4d5d_9475_aa293c6b8d82
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d5f4948b_ec97_451a_a786_6e2b068568d6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c33f229e_8358_48c4_8718_a74dedd46fc5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e1bff2fd_967d_44d5_a41b_03143106ac83
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#fc394105_7841_49fb_ac11_703c1166a9ae
constant: true
size: 1.0E-13
spatial dimensions: 3.0
name: dnabound
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000474#a674b6e0_363c_42b5_a43e_be2e248a7fb1
value: 0.55
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_59dd9848_3fba_4f9c_8fd3_44d6f60374da
constant: true
value: 1000.0
name: sc_pip
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2a38416d_2e63_4f4f_8638_8644318594fd
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c5a39371_7340_4250_87ba_6bce2d3ce472
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a6c6ad7_2df3_48f8_b6fc_8b4cc4396747
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_499b4a85_a309_4298_a146_b983be8fd6ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_40098f1d_8bd0_4a35_aa54_f1657a7fbd5a
value: 0.181818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6e65ed5d_5aae_4324_b32a_8d9de564b28a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6fb289da_e326_4c60_b3d1_0ba6574bf46b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_407d533a_42ba_4570_942b_335b4f6c5838
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_93862840_4ea9_4494_9d1d_86955991cfa1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a101b86e_f393_4a2f_a1b4_539e5caab8ff
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_06d833cb_bcd8_4807_8d1d_d66ba6b1f556
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9672349d_f3af_4c17_8def_526d82171d04
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Ins_InR
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#c12aa074_73d7_4a15_bd8f_4f92b30c264a
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: IRS1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_6fbbfb40_e64e_4e00_b9bc_c11d914987a3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#de5b1071_5b6e_438a_932a_48e6b2662ea7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b0836a24_8c4d_4dc5_83cb_9ccb088674e6
fast: false
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_26b70908_bb5f_47f7_bc08_f1974070b5cf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e8a9d13b_8a01_42eb_b486_7b5b0dca5e09
value: 6.6E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8cc20445_adfb_466c_895e_f8c5dc45a5b7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8ccc4ac1_c46e_4110_848c_116e0f6f8531
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_886c3632_6e7a_4f0a_8fa3_8c08aae22436
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c1e1cb9_3ab1_4083_bac3_65a8403f47d2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d014034c_acb3_43a8_812c_d6d8b0186d06
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0fc923f4_461f_4fff_a31e_926045169df3
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_7bf9b792_c977_4b2c_a2e7_b86b54ae49b4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ccd0443a_4ee3_465b_a459_525ee8efe680
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: Foxo1_pUb0_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_2af92735_4174_4ff3_bec0_023b421b8851
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_02d21dbf_1abf_4a36_8aaf_932929728919
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7b0b709e_7ef1_4d75_b1d1_5c6fcbf05d11
constant: true
value: 2.5E-5
name: k11
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_15de6f51_fb5b_4d70_b374_90e3c4f86f80
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d2bf6714_75cb_4df8_af34_8c64ec25d655
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_61a0cd0a_296d_441d_8ae0_522e8b3303c8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d8602ba9_77a8_4307_ab2d_280bbcc14b67
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 90000.0
name: InR
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_8c9fec66_d5d8_4343_84b7_2f9dd0b995e2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c8272e9_4b96_4e42_a95e_bd19f42492ca
constant: true
value: 1.0
name: cyto_vol
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1e784140_febe_4634_bd43_6e01e3edc98e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6a0cea92_141e_43b9_85d0_0a12a22837b0
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#efd192a3_0eb5_4caa_9eb1_41f53ecd29a4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e43ffc86_169f_4282_a997_16fccb9ecab6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_849c97fb_3af6_4783_8672_2424d34733b1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_84ef82eb_6370_4875_b0eb_0f0baff34bc1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_41f9722c_7771_44d7_99e3_b9ae33485446
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f5b6404b_2c2a_4d2c_8635_516112ff0cba
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_93c8973b_3cf6_4087_9e30_d91a9c9de2f2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_44c5a181_dd45_49c0_91b3_0a657efb98eb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_57fcfac1_8eb2_4de2_9baf_6e4c7ecc0110
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000000.0
name: PI345P3_mol
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_2e87ce81_795c_4e26_8c3b_e0502bf30306
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6afbdf89_f0ea_4cf6_884d_b2c0b93851c8
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_23830899_bb4a_4ef9_ba9d_3d66d79176ac
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d1b73f22_c07a_42b8_8277_5b30536ddc0a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_67705212_6766_4908_8bed_92de90d81851
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c8e5df67_a7b5_422b_b7e6_0515652a017a
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c4656a31_2277_41a1_a737_f40616dd5e3f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_60892d8a_3956_426e_b470_0dcb5e40ff62
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_59b3976f_708e_438d_80ce_0fa078015bef
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: PKC_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#a876b261_e61a_4212_9d2e_4b5de245044c
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e4646d74_904e_4038_aafd_0bff82ffa753
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c47f1a6d_86e3_4e64_9520_a6bd6921f0dc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_90feba42_ca0e_44fb_8b4c_6d9ff8e0f9dc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f880d33_6ad2_404f_85c3_b227c97d7b6e
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8568a819_7f0f_41e1_8da9_d05463260ba3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7aa705bf_77cb_464c_9451_4084072efc23
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: JNK_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#beaf3aa0_0ad9_4c99_82ab_2db82f918fa4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3ba8e64e_0a50_4118_a475_24e1bd955daa
reversible: false
type: Reaction
fast: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#a38f3ae9_b885_4758_8091_b8a18a855052
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_68551366_4931_4749_a047_88fe8ed05ba2
constant: true
value: 1.65E-11
name: vcytoplasm
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1c8169bd_9366_4358_b445_35ba099abfff
constant: true
value: 6.0E-4
name: k32f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a4986347_f949_45d1_841b_c4a33962a3ac
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#f235e5e3_2a70_4a5a_9ca4_c252704e155f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_16e03a77_685b_4943_b679_4fb04b5a6bdd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f83e33b_0eb5_4654_ac7e_578e476e4b57
fast: false
type: Reaction
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_9b829302_013d_4369_a38b_cc8d7e5b0eb9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_06eb2508_b3c4_4230_a86e_42af47b83317
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e0262293_e3c5_4687_8c2e_faa3c673a307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d30f0729_b3a6_4511_b692_b8046925750e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3cddb86a_c5f2_490f_b44f_0c56a45c6890
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9b67223b_01e4_41fc_b5a4_6ecd5c102ba5
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_57840bba_d3d5_4608_b016_5b508a118e83
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d946d748_d434_4faa_a7ac_3ce1cc364c5e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_474a5de3_6589_45ad_9616_5065b01f198d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a7fec2f7_f739_475c_bf8a_0715c0409760
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9bfd1bde_714a_4423_88bf_6b30333a71f5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_36dad78f_ef22_4298_9aca_5d00c779ae48
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#feca77df_b477_4fef_8e29_a1f48e5cc17f
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#dd45d537_b135_4a82_aaf1_b329cdccec8a
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100.0
name: NOX_inact
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_4fd9c475_fc0b_44c5_9e3f_ca031e3b8ce3
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e121eeac_10b4_4fe0_a612_46e8d0791d54
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d8af9598_8e06_4baf_8177_81973c753712
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_15ca9153_24e6_4e36_bd93_e1ce945ba05b
value: 3.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f12827e4_79c8_485c_ae8b_3665450bebf4
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f3a2bd4b_3815_4849_9bbd_cb56cf81a9a0
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6e858a93_5720_4889_b668_4046b6a2244b
fast: false
reversible: false
name: R50r2
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e671db44_e422_443c_bba5_0e7b6de89321
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_465565a0_7f41_4c5b_9e84_c12e6981aecd
fast: false
reversible: false
name: R20r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_277b5d28_a7a7_41e0_9f3e_55f1ef73e783
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7a8075fb_22e1_4c3e_9778_87f1872639b5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: SCF
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_54b84f6f_5c37_4637_9121_8fc644313178
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ffcb2c42_2858_4db6_bd2d_db247733131b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7f1fd42e_2ce6_474a_a1f8_cb6daa8afc99
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Ins_2_InR_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_8791daa1_005d_4714_bdc6_423e5b7b3efd
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#b9636ae7_2fde_47be_9229_32b5f2828688
type: Reaction
reversible: false
fast: false
name: R43r

http://identifiers.org/biomodels.db/BIOMD0000000474#_5892196a_3460_4879_ad2a_d3c52ed67457
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9e42bf60_42ca_47c9_af4f_98dd319d522e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_98e26ccd_90da_4583_89e5_a88d1d675be4
constant: true
value: 0.25
name: k34r2
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_28428318_faba_4e1f_8ec9_7cd74bf614c3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: IRS1_TyrP_PI3K
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_48197003_6c56_4e51_b846_ff3b3b2a267a
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1a648421_de26_4fec_ae5a_b4914167aa10
value: 0.0909090909091
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ca68f3ad_f920_408f_ba16_8360af7c237c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e4474c4c_b609_4fc0_b8e5_8ed34bb7982f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c47f0c80_ab8f_408e_bba3_0d72e6a84f7a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c5ee989a_4354_4eb3_8d9a_1ed09571637d
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d670ff07_8779_48ef_82b5_002850156824
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1d59541c_e3e1_4cf5_8eae_826848a7fa45
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5a78c887_ca90_43cd_8537_d6c97b9fa83e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0c453367_312b_4920_82ce_1b4f645deac4
type: Reaction
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#a7ea9498_b371_4d30_85ef_9228862adc0c
value: 0.55
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d7bdc76a_6912_4453_b9f4_d3dff0ef7463
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: IRS_total
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_81a3e421_e063_47cc_a5c3_00de27d86215
value: 0.181818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#fb293167_c6dc_4bc0_94c2_38b7410d7489
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_38d05ab6_b3b0_45e7_8af2_aca8b5239443
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#aaf7713d_2e4f_4188_aa11_4de16f632f4b
fast: false
reversible: false
type: Reaction
name: degradation of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1

http://identifiers.org/biomodels.db/BIOMD0000000474#ecb238f3_bc0f_48f9_9005_73aaf2eab02a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e8e4bfcd_9247_471d_ab6b_19d9a2c7d649
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f29d19e5_2ffd_45eb_b751_f59f2d83926d
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b49e74c1_b2c2_4d2a_b17d_c3c65688154b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c12dea03_402b_4172_b60d_52db49d4b0b5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5df54f7f_9bd9_41b5_9629_68574621f51f
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: Foxo1_Pa0_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_149baf6b_7ead_4166_89c8_7dd2ab8f2860
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9e8d0980_0151_4994_9608_0743c98f91d6
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#cc3e3626_6431_4b97_a476_bbdfcfe407f8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d34de774_6a71_402d_b349_e70522749b5b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6610e3be_cce8_4237_b53b_70aa88a12571
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0376e9a5_3837_43d2_8a0c_8fd26638ebb5
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Foxo1_Pa1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_4f314300_3751_47fb_87fc_0b325c25b515
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2f16f743_a7ea_4fa8_ac76_d92a46915935
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_54c993c3_f328_4b1d_a2f1_a9fa5af85d06
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4e939731_89e6_402c_b22e_073d7ee47354
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_0dc1dadd_bb46_4f6a_b3b6_1dd0e06d56f7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_013897e1_977f_4641_9cf0_ba111acacfc6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2a489ba0_3fda_4cd4_91ec_ee8c88ded0c4
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#dd2d8a5d_94b0_40e8_a31b_0c4c45e6aa49
constant: true
value: 1.0
name: cellsurf_vol
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d08c7628_d05b_4d23_862c_76d22a7d8e4d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_295b389e_1a54_4cbe_a9dc_9f3f7294c864
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e104821b_a1db_43df_a140_8d229184af4d
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6060931d_f895_4521_a194_af7fb331e623
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_78c184a0_029d_4d9c_bede_ee178349f303
value: 6.6E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8c741145_f998_4691_ac70_03d95c16ab91
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_61f3bf88_a551_428d_a446_117c3bfe3441
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3f5d5772_3789_41d8_90f1_421c7cbcba34
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_89788877_8d50_487a_aba6_0e15627877bb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_51d37414_e1de_4d4c_897c_4d1f731eabd3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e21c25b1_81fe_480d_b70d_15a3187c0fbf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f0326d4d_7209_420f_b48e_149c4ae0bd11
fast: false
reversible: false
name: translation of InR
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#e96d18b2_fd29_4581_9d06_039ba6d8c21b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ad0d8aa5_28a7_401a_b425_2b0581cdb135
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fe5eaa25_e704_423c_b682_2d01c6b95fa1
fast: false
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK

http://identifiers.org/biomodels.db/BIOMD0000000474#_8621cfc3_0690_4f44_aca1_b02dcb64ea24
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_24e64b17_74c2_41dd_a46d_8c1d366d2d4a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7ffc2855_4a6c_4649_9124_4b756ac4fc97
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b83a41d_bb20_47a4_9f9e_a0d66ec1fc84
constant: false
value: 0.0
name: insconc
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f5186a36_73d7_4037_8525_f58c6df00d23
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_874ac013_e7ef_49b2_a1bf_36e2bc94f765
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_060e82a1_38dd_4e9d_9ab7_cf917f932b34
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_51cb6ad6_a89e_4d6e_b32d_047e00542ca2
type: Reaction
reversible: false
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_5f822787_c04e_48ca_bd1e_6bb04539b373
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d7bb2056_c03d_4740_becd_faaf8d0c2484
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7829d2d1_66f4_4db6_8f41_2108ef271176
fast: false
reversible: false
name: R34r3
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#daf918da_e79f_498f_bb09_ee6d365ca92e
name: R42f
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_38456cc1_e5f3_441d_b44b_d673b35a42e7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5da7f90f_20bf_4e71_a283_b59389413ef6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_379d524b_c1ef_498c_b323_249eab7dbae5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8fd5db4d_0f17_4fe6_a62c_926c51f7d7f3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_32b9262a_5217_4786_afbe_5daa38937368
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_94a0f771_df11_4def_a07d_5207d7f48f5d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2a403713_1701_4799_8b6e_e5cd062247a4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: Proteasome
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#dfd0b649_d4c7_4d1a_9e86_0a1ecfd50823
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_441f6dc7_0efa_43df_ba36_031bd2ad361e
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_353cfd4d_917a_48f5_b80f_7add547b0521
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 96000.0
name: cytoplasm_GLUT4
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#cbee1058_69d4_4aa5_9c83_d51fd7efa024
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f58435b1_655a_4281_9171_f5220008d358
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_631328c7_1995_4235_b091_5e1f70cede85
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_84f45372_6392_451f_a256_565b7a81dfc3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ee732cb1_bf59_4d47_8178_f715e4987ec7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5b6214e0_13ae_4f06_a413_74f7a3c434fd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7a341d5e_6437_44e7_ad87_aede0ec3516b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0a949881_202b_4bcf_a4df_143b5f1f796b
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#f871d627_fcf5_49bd_9bd1_90de4b5984bb
reversible: false
type: Reaction
fast: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#eb56f882_33fe_4bd0_a6d3_785521105b7c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dcfcc398_9110_41fe_baf1_d5e5e2c257da
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f175929c_f5be_4a0c_a6f3_19175863bd11
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9c619f54_2d35_4907_a348_e5c58ebcfcc3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#dccdb64a_14ea_4d82_a69a_48c4dbe0c6b0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ed3173c4_6025_4779_ba85_983a4188ede9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_85e9b7ef_877e_4ddb_a3f5_5e3eba407f8a
fast: false
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#ffc49efd_005f_497e_afd6_687cd95d69df
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a6a96af_84d7_446c_82c9_fa04a08aba02
value: 1.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8b7219cb_116f_4ec3_9c4e_9a6d4f8877bd
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a2d42909_a3d7_4665_9737_f598bdf7c8de
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_14dd61d8_69ab_4ea1_85c2_66a84ec2e170
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2e3fee5b_e7bb_4959_840a_032ff7784a0b
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ae37e7ea_c12d_4d6c_b61a_ff8616ac3045
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a3534f84_4717_4918_a403_71b2eca55021
value: 0.55
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3bdf2890_575a_47bf_84f5_e05dbcb15e8d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_60a99111_df9d_4075_917d_bedd2447c1bb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b86d62d5_2025_438c_aca0_e24938a184ad
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_73184639_a645_47be_80cf_936113c8cb63
fast: false
reversible: false
name: R30r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#f7962b34_ba7a_4995_9ca2_ee4214469371
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_75ff6bef_1981_417a_b848_f4c1925cc228
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2edf18cc_c60a_4c3f_8a3f_40a9f67c2d55
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_626d43fb_8f3b_4335_992d_614c76179c07
value: 1.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#db4a1923_6e1d_47cf_97f7_b5698350641a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_39fa605d_ac5a_4cb5_acbe_c4cf5e4ad1bd
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8f3a5f74_9d5b_4f9c_81e5_468bc3500b29
type: Reaction
fast: false
name: R34f
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_736799b1_c27a_4358_89b9_b5e31515fff3
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d9b6994b_8f25_4d8d_ac8e_5a61d15df220
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_472cb627_01ee_40be_bded_93d9051ffc5c
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_736f72bc_5092_435f_9623_03e3fcee6895
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8db67ad5_199a_49ec_8a65_e81c123587c1
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c13e6c3b_ca3b_4995_a7da_9f6904822a6c
stoichiometry: 1.0
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

http://identifiers.org/biomodels.db/BIOMD0000000474#e2b3def9_ec6e_42a4_8f0c_82bb0d012cc0
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c50fe618_32e0_417c_91b5_54008ed2e38d
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f47df251_45ce_49da_9e36_468db414c87c
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9ff722c0_e56c_4cd1_8032_95ac99063123
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e4a21997_781c_4643_a6f2_aea24707540c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e221a5b2_4ba7_4cb7_8153_346b9e074495
name: R52f
fast: false
reversible: false
type: Reaction

ORG:
  orgname: EMBL-EBI
n:
  given: Nick
  family: Juty

http://identifiers.org/biomodels.db/BIOMD0000000474#_1316b314_b2c1_4a5a_84d1_c1c5aa8793be
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ec86d671_b243_46dd_86b2_4079a3014f51
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_89aeb930_5406_453b_a3a7_2acb902d6a99
constant: true
value: 8.3E-12
name: vextracellular
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bdc9e5b5_d8c8_42b2_a26a_0c7005d5942b
constant: false
value: 0.0
name: ros_cyto_conc
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d6453fab_b9d7_4dc4_b030_f0610dbb92eb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_11351124_2a6f_44d8_bbb4_e65d3eea07eb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8547eebb_c9b1_42ba_a7c9_7082ca90c7fd
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7793940d_1f0c_4e7b_9bad_3da7a6f6a379
fast: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_95395161_8266_4afa_86de_42c0181ef18b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_36d82554_ddac_4070_82a8_c6d1aa1c11ed
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b8754825_a926_4ed6_9109_eab1f0f31681
value: 0.181818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9eb3493b_fb3c_415c_ba02_51eb3fc87b46
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_825dbaea_dede_4e18_b2f5_c8b4afbb2b5a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8c3e66e2_5f07_4e35_a0a4_46c97ee0badc
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1c92a196_0da8_45b2_ab5a_c12b34f73396
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 2000.0
name: IKK
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d9f90d44_f59e_497f_a917_35522ef9e5a2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_84321de4_98ae_4e12_9436_5ca67bec16ef
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e82727a5_a223_40f3_b977_58d59ee422c0
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#de19e88f_1ba9_4701_88ed_d437626acbb9
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4c8840c3_f4e6_424f_ab22_ec72cdb0f6b1
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_223b37bf_3686_433a_9a35_f53019d30cf4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_04578aa6_ee19_4013_b90b_fb8df992be3a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_275c306b_07e6_4fca_987a_d04592b5584b
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: Ins_2_InR_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#e80945e3_2a1e_475c_b054_80acdfcf4402
fast: false
reversible: false
name: R16a_r
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_00f50887_26bc_457a_a034_a65eb570b681
fast: false
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#_70bd9cff_79b9_4b2c_b56c_4c5675bbfe9c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b7614a7b_37a4_4e5e_bbfa_bd755a59373a
constant: true
value: 260.0
name: k_irs1_basal_syn
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1d05ae46_4a3d_4b26_b04f_34524d4fd697
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_5b43b7b9_b953_48b2_9fc4_ca3fbf667b50
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#cef3d42e_281f_4aa8_86da_c3aef0081559
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_87c8ca85_c945_4b47_9b83_e856b6cc41c6
reversible: false
fast: false
name: R30f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_104b4dbd_d1bb_4329_9c24_4ea7e0f0da9c
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_06be2765_326e_4664_bbbc_fda1df14c95e
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b37b55b7_dea2_44b7_b4d7_a2893e03b2c9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4229f618_869d_477e_b05a_10012f77d113
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c90058a_ed23_42d3_8f1a_12a28409bf9a
constant: true
value: 0.005
name: k30r
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_81ac7c22_b85d_4973_8902_331e3327e172
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4e7d2715_7e00_467d_99b5_96e98ecf9084
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9be31bff_570e_4aba_8547_b27fd7921389
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_76eaf2bd_e4a0_4e4c_8c2f_970e6ca0c2da
value: 1.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_36604f15_8426_4efe_aacb_be43a63524be
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: DUSP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_27053501_b88e_4110_8d7e_fca1122b61ea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f13fbc0d_62ef_475b_8488_1d807c41ab8c
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_8b48d4ec_72b0_48d9_add6_621cca978ff8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: ROS
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_807fe904_c654_4960_b6b1_82fa1494536d
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d9766d36_0312_4ca3_a583_b24da95bea22
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_35ad8da4_8fe6_4994_ba3e_a21456e0a974
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2b86faef_5814_4757_9ebb_c5aba481c11b
constant: false
value: 4.81
name: k_ros_perm
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d5a5b9d8_de6b_4c4f_8a44_ff366823a7aa
constant: true
value: 0.015
name: k13_basal
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2367eefc_dc67_4213_b2be_1e3f216ce579
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4a35103f_d73f_475b_ac68_16075dd04019
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_66fde86f_4783_4ad5_973e_69e456ff3108
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fc4b7c8b_71f9_46f5_968f_2ce641ed4c9c
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_1779df39_95e2_479c_824d_48c604494339
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_tot
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#ba34c1ef_b77a_4375_b3e3_668c226dca4d
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_006fbfa4_e142_476d_95af_702d6475250c
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#af789f03_fbca_4247_8dfb_7a7c8b56a312
value: 0.055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0aed9008_060a_4791_a685_a7d87399ecc9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9663da03_6a83_4ed1_ac5f_c88339a78db2
fast: false
reversible: false
name: transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c4b670b4_232c_4181_b395_e0dbb60ac622
reversible: false
fast: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#ec588395_2877_4ebb_ac57_bddbdc941999
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_789cd023_b81b_4afb_88cd_0dd683d5767f
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_658d98fc_38ed_40f6_bd51_5487a6282576
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#fd1bf4e0_b516_48c0_af59_b5c27dc1e122
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_65b18cc5_4867_4575_b52b_216e702a7ded
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_05fa1202_23b4_4323_88aa_3ce9bfc8ffc8
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_28a45abb_5118_49a1_99a3_a68f83db314f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#af97bb8d_b551_40b7_8347_ed94ef07f17d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9dba18f9_b726_47b0_b7ff_3699efdedbc8
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f033e744_8ab3_490e_8eb2_6adb4e6452ac
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e788eea2_df6d_4bf1_91f8_69fe16f82ed1
constant: true
value: 6.95
name: kcat52
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ae83508d_9134_40e1_b10c_9247fd68b082
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0b8274e4_fcc4_429b_9cec_e2b83cc84afc
fast: false
reversible: false
name: export of SOD2 RNA
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d8465c89_d97e_4f2c_8041_80ed116550df
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a3c5d57e_b33c_4bdb_af2d_217fb2a6f455
fast: false
reversible: false
name: R50r1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d7872e64_ac43_403f_a2c3_82fad1a23a99
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_45fa3ade_a218_460a_83e2_59e6605c6dba
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#a07f9e24_cf83_4ab5_860e_e4a6b23261d2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e4fe4550_9716_4d5d_9147_2eba31739f5e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#edebeb31_be8d_4907_ab16_359cc8528ba7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1bb805fb_2f07_4ac4_b3ca_ba06b2481cd8
value: 6.6E-5
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#fb4d661d_7ba9_4bd4_bada_a37d25af374a
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e1d7b66e_234b_4d86_b47a_73ef28c83355
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_99325d25_4729_468c_8ac1_3f4eceab6475
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2a0f278a_6d8c_4e6e_9ce4_be909efc810f
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: degr_Foxo1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_3de9e4b5_5f15_484b_ae1b_7ca390ba106e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_91b313ea_459c_45e9_b19f_31e7f082d3ce
stoichiometry: 1.0
type: SpeciesReference

W3 CDTF: Mon Oct 07 22:23:38 BST 2013

http://identifiers.org/biomodels.db/BIOMD0000000474#_79507bcb_6244_432d_bfce_5789fad7b8fb
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_59682f56_78d9_4835_90e1_9605422ea353
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_15eb62e9_d594_4bd0_982e_d5b578169e1d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3aaf57fd_b952_49fc_8ba5_137c77708e1b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e0c49e43_6ee4_4795_8447_bcd3ab99ee31
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e90c44bd_4710_4ae8_8400_ee1ae735d125
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_123e189d_5bea_4b17_8fc2_a3c850adcbb4
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_13def12b_efcf_459d_9293_e495be066c88
stoichiometry: 1.0
type: SpeciesReference

W3 CDTF: Fri Sep 06 17:13:42 BST 2013

http://identifiers.org/biomodels.db/BIOMD0000000474#eb67f951_27b3_4ea8_b062_709e19ffb860
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d510eb19_fe10_4c9a_8877_f9377e1aa04c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b3bce308_39c2_45eb_bd85_b032f26c66b6
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2d3bc3ef_9b26_465e_9239_c9222f19ee6e
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#ebd139c4_3208_4bd9_b1a6_c4d4674b92f6
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_7dbad0d9_e328_44ef_b8df_2c3929d4a86b
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_4b7151fc_c33a_4619_beae_0245acaeb7de
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#e60a6aa4_02dd_4733_bc4a_aaece61c7380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: NOX
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#b080496f_5c9c_44b2_8f22_a6bc8d9cf7cc
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_07f42085_466d_42df_bbc7_63cd22362294
fast: false
type: Reaction
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2

http://identifiers.org/biomodels.db/BIOMD0000000474#_77fad166_7cd8_4b72_9a61_b80a02fd03e4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b23cfd45_41be_4d87_98b0_d9151dbdcb46
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_65a0c6b0_65ba_46a6_8802_5b33b7c30c9d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8a1bb627_70f9_4dd8_bc26_0e383df6defd
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_68894713_53dc_4a84_b05e_23aad8df87b1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f3fca5fa_ce29_4d2d_a2b5_fdaf899b9214
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_045ad39b_8631_4c85_a40e_0f702b590039
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_865fdb45_ad9b_484f_8b0b_fc638e2454b3
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_06fbd913_c643_43ed_ae0b_75ee884c9e23
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#cc1e777f_9835_493e_bfcb_d266466dd765
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1c5f4264_72b4_421e_8133_6ac53713e71f
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_191a4bb4_efa9_46f4_a11e_63dec5c9e624
value: 1.23
name: ktransl
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_02ebf47f_039e_467c_aa95_1fe81a936310
value: 0.055
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_41f59372_0e3c_49cd_9b2b_4a32d3b4a9cf
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_1b60cb40_c9df_4531_b10f_6fdd0c7e9d4a
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_70212ec5_19d0_4553_84d9_27bbb2232d21
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: extracellular_ROS
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_123f98b1_de39_4274_acb6_92262eff5119
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0e1bb031_c847_4695_8c22_8527152a8df9
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#a6a8456a_c26e_4ce3_8a8a_2e6b9ed2c74b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_3c0884d8_ed5c_44e8_ada2_8dab46f40bf1
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8538c557_f30b_40b0_94b8_97d4034c49fe
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_9bae7337_3e7d_49dd_926e_70687ee4f8e1
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5ad5b1e8_d5c2_43cb_8d2a_c90707aeaf47
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2103b2ce_d766_4d77_bfa0_639a394bc9c9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0c58ca22_713b_42ec_8ded_fe65e619ee61
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_18a98c1e_7f25_44f3_b8db_e6bf9af8fa18
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#baf8d5d4_ef03_4dc4_a892_e4c6a4d71b47
value: 0.95
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_0e33845b_cd85_4f15_b263_15ade1a58885
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1af17321_1b64_4c30_9e4b_31cdc439780e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_943a0c43_f81e_4927_a009_a9a63e692ca5
value: 5.5
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_85aedbab_7f6d_4b72_bca6_014c733e86d3
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#f78c087f_169e_41a2_bdf9_98ff6145dc81
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#fafa040c_466b_4a1c_a7fc_e24035a74fa0
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3265196a_6323_4213_ab52_c68329432de6
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_01092596_066c_4277_a3fd_c43bd34757dd
value: 0.25
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ad0873e8_9548_4830_bd9c_0e923c176517
type: Reaction
name: R3f
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_6adff5fd_7075_4359_95ca_2f9b57b65673
fast: false
reversible: false
name: cyto degr of InR RNA
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#d7b6f051_eecf_4310_945c_5643d4ba0531
value: 0.125
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bdbaf7b0_0fba_4dc1_8556_91a8eef6a90a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_84d83bd9_98d6_4ca4_a9aa_ab9df4d24a00
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_925d360a_872b_4d3b_91ac_9a5157fcedb4
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_281743fd_9f2d_48c7_9e72_cc31cc00c334
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9eeaab1f_ba48_48e8_a53b_c4fdc1600432
fast: false
reversible: false
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#e5d66177_8c5f_4026_a1f0_28def1531958
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a4b45156_c353_4251_9a5d_9dcfc8163f71
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1cb8dcee_bf0b_4bae_8c16_2105fa16cef0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_725bc1d7_e1de_4976_bac6_83750a8b3e5c
fast: false
type: Reaction
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF

http://identifiers.org/biomodels.db/BIOMD0000000474#cbaa83d7_b36e_473f_a34c_4fa6e17c215b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0274d379_3349_4ad9_8672_2f95544b8fb7
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9aad7c60_e8dd_474b_95f4_491cbeb39f5d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a25275bc_a361_493e_90d7_636273e832ed
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d537ccd1_e7b4_47ec_8d8b_1684dfed70f4
value: 1.0E-4
name: kdeg
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d369885c_bb0c_4655_9462_82f89f776a66
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#eb73b45a_c47e_4716_aea1_0e4c3360e72c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5f3a00f0_e8e4_4a20_8ba7_4fda6c869b64
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4c4afb4e_07ee_47cc_b334_0d3f35dc626f
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
name: PTEN
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#ec8e02c4_b3a1_4dc2_90ca_b7c94432f804
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_55bcfb0d_dafb_41f0_88eb_4a7a7a88f912
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#b7127040_ab2f_426b_99ff_d94db865f36b
fast: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_904f6d65_412d_466d_9b7c_3ab688d20286
constant: true
value: 1.0E-6
name: kminusr16a
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_96cbaa1c_2bb3_48fc_9bf3_ea8ca4921fda
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ce7ab48d_83ca_4e21_91a3_091be8e42263
constant: true
value: 0.001
name: k34r1
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_756f8393_f6a0_4126_aa62_b2ea4ece0f65
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e999da8c_e930_4994_a496_b228e11ca547
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_733134df_7474_40be_8d52_4d0c6303b95d
type: Reaction
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P

http://identifiers.org/biomodels.db/BIOMD0000000474#_3ee60c07_3ac8_49b4_84c3_5dfb79eb9103
reversible: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_1dd98fda_5c8c_4d4b_82b1_30956e10467a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b730565c_27b0_4fa2_b2bd_5e1ea3b6e7c7
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6c6d159e_f6ac_480e_8219_4f6d2427582c
fast: false
type: Reaction
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#d36988e6_52a4_4b04_bbcb_820c91141d4e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_30c29e61_3451_4a81_8261_f54ac27ad642
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5e8bc3a0_41cc_4b14_96ec_c4513ec6e9d2
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_28422e6b_4e2d_4c13_9a1d_6d54a0dc30c4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#daabcae4_056b_475c_8b26_3be4a6a8fbcc
fast: false
name: degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_5399ae04_6167_4e6f_86e5_f647e150d4ec
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_0691d505_892a_4177_b15d_0de36dedefc3
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b92f79ef_f5ca_4405_bfc8_7879ef9d2ac5
fast: false
type: Reaction
reversible: false
name: degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1

http://identifiers.org/biomodels.db/BIOMD0000000474#_008c5036_0b39_49eb_a262_69de93d22398
fast: false
reversible: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#a015d9bd_0ce8_49b1_9ba2_cea7038234ad
fast: false
reversible: false
type: Reaction
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF

http://identifiers.org/biomodels.db/BIOMD0000000474#_24e4067f_535b_4859_9b7b_382a13ab7899
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#db941780_4007_44de_8967_760c2367de2d
fast: false
reversible: false
name: R36f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3532c9a0_f4f9_41ef_a64b_48a05c74773f
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#cb7d1ec0_6f5e_4b37_9096_62c466628b71
value: 0.0181818181818
name: ktr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b644817b_aa91_4732_9b17_f83803035b63
name: R1f
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_3109d611_603d_4516_b793_046d7d7a9ded
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_491d5155_00c0_4a62_80b5_e9f663e91188
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b15a3e7d_e2fc_46ac_8690_b1c4a001afb4
name: conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_8c0e49d4_4971_43d7_9e59_6cb685e46154
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a3e64a6b_dcef_45e1_ab3e_2a2e0bb89c00
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_48c15ab7_c445_4001_8156_a81d55e3131a
reversible: false
name: R13f
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_863b2e88_788f_4669_8793_6e8a21c42096
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_288b4c69_d859_4456_b106_c7777e7ac590
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_089eba4d_f118_4989_bfb1_7fb3fbc74d72
fast: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_11ffeab7_96db_42ac_acda_2f4de328a97c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a213da4c_2dae_4404_b24e_6d98eebf810f
constant: true
value: 5.8
name: k7
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_32fd70b0_3a42_4a3f_b18a_10d23c431e05
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cb43d975_a0e7_4fb9_a7b2_176f6473a080
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#fdba103b_9490_4571_8458_aaea8c84ce2b
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_9b471d78_952e_4c9b_bb71_91284e4a24c9
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4eb5a5fc_9469_4210_ab72_42d07d6f6565
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a2f36593_367b_4a79_b46b_9d2a43e86b97
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#efa2b521_6726_4b40_acbc_cae9ead4a4a0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b8f1ce03_7804_49c9_8125_43cca09497c3
fast: false
type: Reaction
reversible: false
name: R32r

http://identifiers.org/biomodels.db/BIOMD0000000474#_5594add8_27db_4802_af2c_5efdf6bbcfd3
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_8cb281d1_9263_49e0_ba2f_0486b72f4978
fast: false
reversible: false
name: transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_4ec0eea1_fe40_4728_a68f_54f9ac92469d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0501a755_4105_4c96_af32_027a41ac2925
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b9582bff_7fe8_4c29_a0ef_a4666c10f1c8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e3bea1f0_b3c3_4e84_8f0b_6383cae8bfa0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7009c355_b5dc_4477_a21e_4e251e99203f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2659d2c9_eb59_4f93_b6c6_0e097822891b
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#ef63c640_0e3e_4d7d_a7da_d2b32a625bac
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#dd3f6ff7_d4e7_4ebd_b31f_287bc65beab4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_877911d5_aa80_4b38_92ae_ed9c12b904fb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_284b56d1_e1fe_4a3b_93f0_3952d30e6c32
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_379141b8_e5d9_4d51_b971_65e0183ecfe4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aefa4e12_30a8_46a8_b3d4_ea94ef5b402d
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#b6feb1cf_181c_44ee_8715_20f2bc176199
constant: true
value: 100.0
name: Km51
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d78e0db1_db76_4b56_a579_0c806e6c4b7f
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#b4b5b727_541a_4d3f_ab7a_c95a09806bf8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7c2743b7_c3a5_4b32_893c_3902645c860f
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6be87c67_b332_448b_8329_93f1fc2e708f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cc7fe296_cb4a_401f_ac8c_64cedf7f36d2
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a5cf2d1a_f5d3_4024_936b_b2e12a1031ac
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_14448c48_3e9b_433b_9b43_f027f93d9ea2
constant: true
value: 3.0
name: by_ikk_phos_factor
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_2421c09e_a5e3_4d92_b1bf_b303745f80d2
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6d851a93_d5c7_4be3_a212_6a86fe1a489b
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_02789319_626a_49a6_b189_faf45d38823d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_59f0e399_5ed7_4416_adf5_65bcd57671c9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1994267b_b246_4003_9437_ece883063147
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c9a39b8b_9d72_42c5_9295_a8d30e1c9253
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_35d5e7fe_8575_4341_9de9_c9ed6af866ea
reversible: false
type: Reaction
fast: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A

http://identifiers.org/biomodels.db/BIOMD0000000474#db79d1d3_c3ad_49e9_b108_ce8b6326d054
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ef96cbdb_570e_4595_b7da_ec2730351949
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e8bfe084_7ec2_41cb_9279_f3cbabadfb39
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_7e945052_bec2_44e4_893b_c01cc4903d13
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a8a81e40_ff3c_46a7_a055_fd3e6d705445
value: 1.0E-6
name: kdephos
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#d6d928ee_7266_49bf_9139_d5c03358fca0
fast: false
reversible: false
name: R12_a_f
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#c1efbab3_f138_4068_90a3_0c5f3b2f3e81
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_8e6c2dbe_31cd_4720_965b_0a032c0f72bc
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_1f95bcf5_c5cc_4b7e_b909_5089f4e77a6e
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#ca5c858c_36fa_47d2_a0e5_5ee6453b828a
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4ecc95e5_ecd4_4ebc_aaad_cebfdbd623af
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_5f268b37_9988_4b8f_9d14_d83722b22195
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_10522afa_e4c8_4a85_9c0e_55b9f254cbea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bafcd083_12be_4db6_bb5d_7c1db36a14bd
value: 1.0E-6
name: kub
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e1490571_7b08_4449_841a_3ee5c834f1f5
type: Reaction
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1

http://identifiers.org/biomodels.db/BIOMD0000000474#e1b6e835_ea1d_408c_8a54_2f0ef71308a5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b95fbddd_c430_4ecb_b7de_0b00aa877a6b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_635785bf_4b01_42de_9faa_761039712b6b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#e3d91e51_43a0_4c95_8b85_1e3fe3591a5e
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
name: CBPP300
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#e6ad4864_0716_49d8_af9f_4d91722a7fb1
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_6c7171f8_2452_4ebf_b0d6_b8b402ea6552
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
type: Reaction
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_58c0e413_3002_4a45_a4dd_6d1f36385101
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_48fae61f_4817_4afd_9e31_e1f67ed5f311
fast: false
name: R14r
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_50abe5e7_95eb_452a_b2bb_0d0437a53a49
constant: true
value: 2.7E-4
name: k31f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e4a0b6d6_bcb8_465b_8380_a8221242241d
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_639278eb_71b1_42ce_a83b_ab0c7c480b0f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_91771859_1fd2_44fc_9dcf_94602ee0f9e0
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_5938ff97_135f_48f2_a30a_65c6bba28109
value: 3.0E-4
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bf367dcc_70b7_41c3_b867_681d4ff97e6b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_33ed40c3_0a6d_47ec_8d38_50e7b9b10aeb
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_1a68e6d8_815f_4579_9425_9acdf5e18be7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 4000.0
name: cellsurface_GLUT4
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_00b10672_4a6e_42fe_88d9_6242ad4947ae
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_90f2a55a_b436_4c83_968c_c1104129d4c5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#b2b7ac52_230b_4a91_ba71_c7e2657360b5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a6af398a_418c_4498_805b_6d36808a7c98
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_0cec2ba7_8e6a_4716_aa20_59e73c0f58df
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9371158e_2bcd_43cf_9521_a48d085c458f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c0c9edec_ae3c_4b28_b3d7_54dbe1d7f00d
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ee39ac28_5e6b_4a2b_9765_aebbcdc5a140
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#aa743450_2608_4744_b532_cea6664e5a05
fast: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_2e4dad4c_1a7a_4a48_91e4_a4ff3bb39cea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2ef674aa_3239_452b_bda7_45940a616bdd
stoichiometry: 1.0
type: SpeciesReference

ORG:
  orgname: Newcastle University
n:
  given: Graham
  family: Smith

http://identifiers.org/biomodels.db/BIOMD0000000474#_2d2d2510_527c_46b9_b48f_43eeaaa2cbef
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_9617af22_485c_43f0_ace7_e7c902a95be6
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#dd36c02e_34bb_4755_aeef_1c84ab427c2a
constant: true
value: 0.08
name: k30f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e1e202d5_511c_4544_982f_70a62cab9a97
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4942606b_66c1_44d8_956a_af6742554488
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#bc72cb99_b11b_45aa_9996_ff95ce5bae7e
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#bbbad9b8_626b_450c_abb0_b3def25506ea
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#c6456792_2b71_455d_a450_f5e69bb678fe
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4e0a94fd_1652_4f44_84ff_f4de9de957d1
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_1fce30c0_3408_4f06_b1d1_a6486897474a
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_RNA_SOD2
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_42dfe6a8_e54d_4ee5_b9bd_51da42aaccc9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_2ad1244a_ce86_42ed_9222_df283a1c56a5
constant: true
value: 2.0E-5
name: k1
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_3272a515_8a59_41f5_a1b4_6f09de8e0896
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_52561c88_8d58_4135_a5bf_521ab6ca6599
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#cf7376bd_ca89_4ec2_a061_8af590440dd5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_80589f87_ff1e_4ee3_a65b_4b95bdf22a46
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
name: USP7
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#b56c1ffc_d869_478f_bb17_f36b48bacc26
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7478b3f5_7375_4a83_bf08_f6fedd6697a9
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_4005afa4_b7e1_4814_ac05_6009767176e4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_6c757d40_43c6_45ae_9ea8_5331348aebde
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_49ed15c5_2d17_4c41_b182_b3c8fe77e906
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_59117295_c9ca_4412_9afe_8b8741b2f31b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_777c8bc9_f580_4b00_ad6d_6d477c09791a
constant: true
value: 6.5E-9
name: membrane_area
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c9ecef2e_0108_4863_980f_83123d3e5c9f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#f0e94fd1_b770_4b96_b99f_f08838ffa34e
fast: false
reversible: false
name: R34r1
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_3493d3b5_db10_4b87_9fdc_b9b324363382
name: conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000474#_015112ce_7228_4c75_b413_9da8353ced10
fast: false
type: Reaction
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#d21ef238_31c6_4a92_ba9d_39ce58eaf3f3
constant: true
value: 5.0E-5
name: k42f
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_979909f2_d3ea_4f6e_a2c2_2b8152fce56e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_22de301f_549f_4c04_bb88_7a6fe34869d3
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#c6197580_1751_4d51_a860_8b29b90905fd
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: PTEN_ox
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#d01e41a8_ec8f_44f7_8456_b271a88a16d8
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_52e73583_323f_4c34_aa7b_b84865666de5
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#ea6d7e6e_d9a7_46ae_8766_4f7b8d99ec88
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
name: nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_410116fb_2da7_42cc_a82d_950f7bd4a26d
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000474#_5ad06430_fc6b_4a6f_91e6_683452a9f345
constant: true
value: 0.01
name: k_irs1_polyserp_degr
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000474#fb140fa6_57f3_4b07_86e5_081c5b0e19f0
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a4d061f6_7f61_4bd8_97ce_2753076cf6d4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bbfd7663_0f87_485f_bec9_b5cc9450ce4e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#bddbcad3_56ea_49e0_affe_351f4471790c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_7229518f_7463_471b_b398_52516e35c5e2
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_16462cd1_36aa_4c73_bc2d_6364f499c050
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#afcbfffc_6b22_4fab_b4e6_789ee5e536cf
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#a7141a96_e1a4_4e9a_b643_9f57d88c0f9c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_19e3440e_3e63_4ed3_9f23_566c81b77d2b
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_35b7c2d8_56f2_4146_b310_b18fec71179a
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 16000.0
name: JNK_plus_JNK_P
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000474#_1a12a4c9_d9e4_4ef8_92c0_7e444414ccf0
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#bf1b47bb_d285_409e_9c4f_ff16035338f0
value: 5.0E-5
name: kkin
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#_6b30fc5a_593d_435e_8606_5e5aaff962c4
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#d0b6204f_7203_4027_9161_cd09fe55687c
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_52365e65_65d5_45a6_a06d_24ca6f80837e
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_707074f1_5204_4087_97ae_df6adde8bb8d
value: 0.24
name: ktranscr
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000474#e1f48162_4ad8_4525_8c45_78462389e71f
stoichiometry: 1.0
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000474#_172c2b7d_38c8_4e4b_9b00_0eeddd9519a8
value: 1.0E-6
name: kdephos
type: LocalParameter