re138
kinetic law: CDMT00311
product: CDMT00299
product: CDMT00298
reactant: CDMT00297
fast: false
reversible: false
type: Reaction

CDMT00238
stoichiometry: 1.0
species: s43
type: SpeciesReference

tf
units: substance
value: 15.0
type: LocalParameter

ktr1k2
units: nM inv s
value: 9.0E-6
type: LocalParameter

re50
fast: false
reactant: CDMT00040
type: Reaction
kinetic law: CDMT00042
reversible: true
product: CDMT00041
modifier: CDMT00043

CDMT00265
stoichiometry: 1.0
species: s116
type: SpeciesReference

delay
units: dimensionless
value: 5.0
type: LocalParameter

re128
kinetic law: CDMT00258
product: CDMT00257
reactant: CDMT00256
fast: false
reversible: false
type: Reaction

dot q instim
constant: true
units: sub sec
value: 2500.0
name: dot_q_instim
type: Parameter

s63
constant: false
type: Species
substance units: substance
in compartment: c1
has only substance units: true
initial amount: 500000.0
boundary condition: false
is: SBO:0000291
name: L-Arg
initial concentration: NaN

CDMT00210
stoichiometry: 1.0
species: s101
type: SpeciesReference

CDMT00224
stoichiometry: 1.0
species: s104
type: SpeciesReference

re108
kinetic law: CDMT00186
product: CDMT00185
reactant: CDMT00184
fast: false
reversible: false
type: Reaction

CDMT00279
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

s39
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: Time
type: Species

s12
initial concentration: NaN
substance units: substance
is: SBO:0000331
in compartment: c1
constant: false
name: TimeT
type: Species
boundary condition: false
initial amount: 0.0
has only substance units: true

re51
reversible: false
reactant: CDMT00027
reactant: CDMT00028
product: CDMT00029
fast: false
type: Reaction
kinetic law: CDMT00044

re118
product: CDMT00221
kinetic law: CDMT00223
reversible: false
reactant: CDMT00220
modifier: CDMT00222
type: Reaction
fast: false

re70
kinetic law: CDMT00137
product: CDMT00135
reactant: CDMT00134
fast: false
reversible: false
type: Reaction

s25
type: Species
has only substance units: true
constant: false
boundary condition: false
name: PDK1_cyto
substance units: substance
initial amount: 999.754
is version of: Q15119
in compartment: c1
occurs in: GO:0005622
initial concentration: NaN

CDMT00176
stoichiometry: 1.0
species: s112
type: SpeciesReference

CDMT00239
stoichiometry: 1.0
species: s100
type: SpeciesReference

CDMT00195
stoichiometry: 1.0
species: s115
type: SpeciesReference

re139
kinetic law: CDMT00312
product: CDMT00302
product: CDMT00301
reactant: CDMT00300
fast: false
reversible: false
type: Reaction

unimol
units: substance
value: 1.0
type: LocalParameter

gam
constant: true
units: time
value: 0.1
name: gam
type: Parameter

tr2
units: nM inv s
value: 3.0E-6
type: LocalParameter

k 6
units: inv sec
value: 5.0
type: LocalParameter

re129
kinetic law: CDMT00262
modifier: CDMT00261
product: CDMT00260
reactant: CDMT00259
fast: false
reversible: false
type: Reaction

CDMT00264
stoichiometry: 1.0
species: s51
type: SpeciesReference

s64
in compartment: c1
constant: false
type: Species
has only substance units: true
substance units: substance
boundary condition: false
initial amount: 0.0
initial concentration: NaN
name: NO
is version of: CHEBI:16480

CDMT00211
stoichiometry: 1.0
species: s97
type: SpeciesReference

CDMT00225
stoichiometry: 1.0
species: s99
type: SpeciesReference

re109
kinetic law: CDMT00190
product: CDMT00189
product: CDMT00188
reactant: CDMT00187
fast: false
reversible: false
type: Reaction

CDMT00278
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

s38
constant: false
name: pre_time
initial amount: 0.0
substance units: substance
initial concentration: NaN
in compartment: c1
has only substance units: true
boundary condition: false
is: SBO:0000347
type: Species

CDMT00185
stoichiometry: 1.0
species: s91
type: SpeciesReference

re119
kinetic law: CDMT00226
product: CDMT00225
reactant: CDMT00224
fast: false
reversible: false
type: Reaction

s13
in compartment: c1
boundary condition: false
is: SBO:0000291
substance units: substance
constant: false
name: s13
type: Species
has only substance units: true
initial amount: 0.0
initial concentration: NaN

re52
fast: false
product: CDMT00049
reactant: CDMT00045
reversible: true
type: Reaction
kinetic law: CDMT00062
modifier: CDMT00050

re71
kinetic law: CDMT00142
product: CDMT00140
product: CDMT00139
reactant: CDMT00138
fast: false
reversible: false
type: Reaction

CDMT00112
stoichiometry: 1.0
species: s27
type: SpeciesReference

s24
has only substance units: true
boundary condition: false
in compartment: c1
type: Species
initial concentration: NaN
constant: false
initial amount: 3.0
substance units: substance
name: PDK2
is version of: Q15119

CDMT00139
stoichiometry: 1.0
species: s51
type: SpeciesReference

CDMT00194
stoichiometry: 1.0
species: s108
type: SpeciesReference

CDMT00253
stoichiometry: 1.0
species: s107
type: SpeciesReference

s66
has part: P08238
type: Species
substance units: substance
name: Hsp90-eNOS
initial concentration: NaN
has only substance units: true
constant: false
in compartment: c1
boundary condition: false
initial amount: 0.083

CDMT00263
units: nM inv s
value: 20.0
type: LocalParameter

re106
fast: false
reversible: true
product: CDMT00178
reactant: CDMT00176
kinetic law: CDMT00179
type: Reaction
reactant: CDMT00177

CDMT00088
stoichiometry: 1.0
species: s51
type: SpeciesReference

s37
type: Species
constant: false
is: SBO:0000291
initial concentration: NaN
in compartment: c1
name: s37
initial amount: 10000.0
has only substance units: true
boundary condition: false
substance units: substance

CDMT00188
stoichiometry: 1.0
species: s98
type: SpeciesReference

s65
type: Species
substance units: substance
in compartment: c1
has only substance units: true
boundary condition: false
initial amount: 0.643
has part: P08238
constant: false
name: Hsp90-p-eNOS
has property: MOD:00696
initial concentration: NaN

V37
units: nM inv s
value: 0.375
type: LocalParameter

re72
product: CDMT00144
reactant: CDMT00143
product: CDMT00145
kinetic law: CDMT00147
fast: false
type: Reaction
reversible: true

re37
product: CDMT00026
fast: false
kinetic law: CDMT00086
type: Reaction
reactant: CDMT00025
reversible: false
reactant: CDMT00024

s27
boundary condition: false
name: pp-AKT:PI3P
has property: MOD:00696
substance units: substance
has part: http://identifiers.org/pubchem.compound/53480352
constant: false
type: Species
has part: P31749
initial amount: 1.723
in compartment: c1
has only substance units: true
initial concentration: NaN

s14
is version of: O15530
initial concentration: NaN
substance units: substance
constant: false
name: PDK1
type: Species
initial amount: 0.246
in compartment: c1
boundary condition: false
has only substance units: true

re53
kinetic law: CDMT00063
product: CDMT00053
product: CDMT00052
reactant: CDMT00051
fast: false
reversible: false
type: Reaction

CDMT00138
stoichiometry: 1.0
species: s66
type: SpeciesReference

CDMT00252
stoichiometry: 1.0
species: s42
type: SpeciesReference

re10
kinetic law: CDMT00048
product: CDMT00047
reactant: CDMT00046
fast: false
reversible: false
type: Reaction

CDMT00089
stoichiometry: 1.0
species: s50
type: SpeciesReference

re107
kinetic law: CDMT00183
type: Reaction
product: CDMT00181
reversible: true
product: CDMT00182
fast: false
reactant: CDMT00180

CDMT00100
stoichiometry: 1.0
species: s48
type: SpeciesReference

CDMT00187
stoichiometry: 1.0
species: s114
type: SpeciesReference

CDMT00213
stoichiometry: 1.0
species: s96
type: SpeciesReference

s15
initial concentration: NaN
type: Species
boundary condition: false
initial amount: 150.0
substance units: substance
name: PP2A
has only substance units: true
is version of: GO:0000159
in compartment: c1
constant: false

CDMT00110
stoichiometry: 1.0
species: s26
type: SpeciesReference

re54
type: Reaction
product: CDMT00055
modifier: CDMT00056
reversible: true
reactant: CDMT00054
kinetic law: CDMT00064
fast: false

V22
units: nM inv s
value: 0.05
type: LocalParameter

CDMT00173
stoichiometry: 1.0
species: s112
type: SpeciesReference

re38
reactant: CDMT00087
type: Reaction
reversible: true
kinetic law: CDMT00090
product: CDMT00089
reactant: CDMT00088
fast: false

s26
name: p-AKT:PI3P
initial amount: 1.457
substance units: substance
in compartment: c1
has only substance units: true
initial concentration: NaN
boundary condition: false
has part: http://identifiers.org/pubchem.compound/53480352
has property: MOD:00696
constant: false
type: Species
has part: P31749

CDMT00248
stoichiometry: 1.0
species: s104
type: SpeciesReference

tau
units: dimensionless
value: 0.55
type: LocalParameter

re104
kinetic law: CDMT00171
product: CDMT00170
type: Reaction
fast: false
reactant: CDMT00168
reversible: true
reactant: CDMT00169

re11
kinetic law: CDMT00020
product: CDMT00019
reactant: CDMT00018
fast: false
reversible: false
type: Reaction

CDMT00302
stoichiometry: 1.0
species: s47
type: SpeciesReference

s49
constant: false
initial amount: 10.0
type: Species
boundary condition: false
encodes: Q9Y5W3
in compartment: c1
substance units: substance
has only substance units: true
initial concentration: NaN
name: KLF2

CDMT00269
stoichiometry: 1.0
species: s50
type: SpeciesReference

re114
fast: false
modifier: CDMT00208
reversible: false
kinetic law: CDMT00209
type: Reaction
reactant: CDMT00206
product: CDMT00207

CDMT00234
stoichiometry: 1.0
species: s38
type: SpeciesReference

CDMT00172
stoichiometry: 1.0
species: s110
type: SpeciesReference

CDMT00289
stoichiometry: 1.0
species: s118
type: SpeciesReference

CDMT00275
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

V39
units: nM inv s
value: 0.05
type: LocalParameter

CDMT00214
stoichiometry: 1.0
species: s100
type: SpeciesReference

s16
name: AKT
substance units: substance
initial concentration: NaN
boundary condition: false
initial amount: 167.616
in compartment: c1
constant: false
is version of: P31749
type: Species
has only substance units: true

re21
kinetic law: CDMT00141
reversible: false
product: CDMT00113
reactant: CDMT00112
product: CDMT00114
type: Reaction
fast: false
modifier: CDMT00115

CDMT00206
stoichiometry: 1.0
species: s97
type: SpeciesReference

re31
kinetic law: CDMT00236
product: CDMT00235
reactant: CDMT00234
fast: false
reversible: false
type: Reaction

V18
units: nM inv s
value: 0.125
type: LocalParameter

CDMT00228
stoichiometry: 1.0
species: s35
type: SpeciesReference

CDMT00182
stoichiometry: 1.0
species: s93
type: SpeciesReference

CDMT00181
stoichiometry: 1.0
species: s114
type: SpeciesReference

CDMT00249
stoichiometry: 1.0
species: s44
type: SpeciesReference

fracK
constant: true
units: substance
value: 7071067.81
name: fracK
type: Parameter

re12
kinetic law: CDMT00023
product: CDMT00022
reactant: CDMT00021
fast: false
reversible: false
type: Reaction

CDMT00268
stoichiometry: 1.0
species: s47
type: SpeciesReference

CDMT00301
stoichiometry: 1.0
species: s57
type: SpeciesReference

s48
has part: CHEBI:29108
boundary condition: false
in compartment: c1
constant: false
initial amount: 347.52
name: CaM-Ca2
has only substance units: true
initial concentration: NaN
type: Species
substance units: substance
has part: P62158

CDMT00235
stoichiometry: 1.0
species: s39
type: SpeciesReference

re115
kinetic law: CDMT00212
product: CDMT00211
reactant: CDMT00210
fast: false
reversible: false
type: Reaction

CDMT00199
stoichiometry: 1.0
species: s103
type: SpeciesReference

s28
has part: http://identifiers.org/pubchem.compound/53480352
boundary condition: false
name: AKT:PI3P
has part: P31749
initial amount: 29.203
in compartment: c1
type: Species
substance units: substance
constant: false
has only substance units: true
initial concentration: NaN

CDMT00274
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

re22
reactant: CDMT00116
modifier: CDMT00118
kinetic law: CDMT00146
type: Reaction
product: CDMT00117
fast: false
reversible: false

s17
name: PI3P
initial concentration: NaN
boundary condition: false
in compartment: c1
substance units: substance
initial amount: 0.345
is version of: http://identifiers.org/pubchem.compound/53480352
has only substance units: true
constant: false
type: Species

CDMT00207
stoichiometry: 1.0
species: s101
type: SpeciesReference

CDMT00087
stoichiometry: 1.0
species: s48
type: SpeciesReference

re105
type: Reaction
product: CDMT00173
reactant: CDMT00172
kinetic law: CDMT00175
modifier: CDMT00174
reversible: true
fast: false

BIOMD0000000468
species: s18
reaction: re13
species: s65
reaction: re17
parameter: K5
reaction: re129
reaction: re116
reaction: re56
reaction: re30
parameter: gam
species: s104
species: s13
reaction: re45
species: s60
species: s25
species: s10
parameter: k11
parameter: k5
species: s94
reaction: re10
compartment: c3
species: s108
species: s17
species: s64
species: s1
reaction: re111
species: s12
parameter: kp
species: s47
parameter: K2
species: s98
units def: inv subsec
parameter: tau II
reaction: re71
parameter: kr90
parameter: k6
compartment: default
reaction: re4
substance units: substance
species: s35
species: s16
reaction: re11
species: s63
units def: inv sec
parameter: Vdp
reaction: re112
reaction: re28
reaction: re15
parameter: K3
reaction: re72
species: s51
species: s39
species: s111
parameter: Cao
units def: length
reaction: re137
species: s102
reaction: re5
reaction: re43
reaction: re8
reaction: re139
parameter: k3
reaction: re40
species: s92
compartment: c1
species: s22
reaction: re128
reaction: re55
species: s38
species: s106
parameter: k90
occurs in: http://identifiers.org/taxonomy/9606
parameter: dot Vhi
parameter: Kmp
parameter: Kmdp
species: s45
reaction: re9
species: s96
species: s26
parameter: k4

CDMT00288
stoichiometry: 1.0
species: s65
type: SpeciesReference

CDMT00257
stoichiometry: 1.0
species: s42
type: SpeciesReference

re13
kinetic law: CDMT00149
product: CDMT00120
reactant: CDMT00119
fast: false
reversible: false
type: Reaction

re102
product: CDMT00150
modifier: CDMT00153
type: Reaction
reactant: CDMT00148
fast: false
reversible: true
modifier: CDMT00151
kinetic law: CDMT00154

CDMT00246
stoichiometry: 1.0
species: s104
type: SpeciesReference

CDMT00170
stoichiometry: 1.0
species: s110
type: SpeciesReference

CDMT00300
stoichiometry: 1.0
species: s60
type: SpeciesReference

CDMT00267
stoichiometry: 1.0
species: s117
type: SpeciesReference

s18
initial amount: 0.1
name: PTEN
substance units: substance
constant: false
initial concentration: NaN
boundary condition: false
type: Species
in compartment: c1
has only substance units: true
is version of: P60484

re116
product: CDMT00214
reversible: false
type: Reaction
kinetic law: CDMT00216
fast: false
reactant: CDMT00213
modifier: CDMT00215

CDMT00098
stoichiometry: 1.0
species: s26
type: SpeciesReference

CDMT00277
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

ORG:
  orgname: Massachusetts Institute of Technology
n:
  given: Andrew
  family: Koo

CDMT00287
stoichiometry: 1.0
species: s118
type: SpeciesReference

CDMT00184
stoichiometry: 1.0
species: s98
type: SpeciesReference

CDMT00298
stoichiometry: 1.0
species: s57
type: SpeciesReference

re14
kinetic law: CDMT00076
reversible: false
modifier: CDMT00075
reactant: CDMT00073
fast: false
type: Reaction
product: CDMT00074

CDMT00256
stoichiometry: 1.0
species: s107
type: SpeciesReference

CDMT00313
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00266
stoichiometry: 1.0
species: s45
type: SpeciesReference

re103
modifier: CDMT00161
reversible: true
fast: false
type: Reaction
product: CDMT00160
kinetic law: CDMT00163
reactant: CDMT00159
modifier: CDMT00162

inv nM s
unit: CDMT00313
unit: CDMT00284
name: inv_nM_s
type: SBMLUnitsDef

CDMT00237
units: nM inv s
value: 1.0
type: LocalParameter

re20
fast: false
product: CDMT00110
type: Reaction
kinetic law: CDMT00136
reactant: CDMT00109
reversible: false
modifier: CDMT00111

CDMT00217
stoichiometry: 1.0
species: s100
type: SpeciesReference

CDMT00276
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

CDMT00099
stoichiometry: 1.0
species: s52
type: SpeciesReference

re117
kinetic law: CDMT00219
product: CDMT00218
reactant: CDMT00217
fast: false
reversible: false
type: Reaction

CDMT00227
stoichiometry: 1.0
species: s106
type: SpeciesReference

CDMT00286
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00085
stoichiometry: 1.0
species: s28
type: SpeciesReference

s19
boundary condition: false
name: PIP2
constant: false
type: Species
has only substance units: true
initial concentration: NaN
initial amount: 6967.271
in compartment: c1
is version of: CHEBI:18348
substance units: substance

CDMT00299
stoichiometry: 1.0
species: s47
type: SpeciesReference

k CCE
constant: true
units: inv subsec
value: 0.0
name: k_CCE
type: Parameter

CDMT00119
stoichiometry: 1.0
species: s14
type: SpeciesReference

re6
kinetic law: CDMT00017
product: CDMT00016
reactant: CDMT00015
fast: false
reversible: false
type: Reaction

k59
units: inv sec
value: 7.5
type: LocalParameter

CDMT00073
stoichiometry: 1.0
species: s19
type: SpeciesReference

length
unit: CDMT00275
name: length
type: SBMLUnitsDef

Km61
units: substance
value: 80000.0
type: LocalParameter

re110
kinetic law: CDMT00193
product: CDMT00192
reactant: CDMT00191
fast: false
reversible: false
type: Reaction

k90
constant: true
units: inv subsec
value: 0.002
name: k90
type: Parameter

k 107
units: inv sec
value: 546.0
type: LocalParameter

volume
unit: CDMT00276
name: volume
type: SBMLUnitsDef

re15
modifier: CDMT00079
fast: false
type: Reaction
kinetic law: CDMT00080
product: CDMT00078
reversible: false
reactant: CDMT00077

CDMT00031
stoichiometry: 1.0
species: s3
type: SpeciesReference

s45
substance units: substance
has part: P62158
name: eNOS-CaM-Ca4
has only substance units: true
initial concentration: NaN
initial amount: 0.0415
constant: false
type: Species
has part: CHEBI:29108
in compartment: c1
boundary condition: false

CDMT00230
stoichiometry: 1.0
species: s37
type: SpeciesReference

CDMT00082
stoichiometry: 1.0
species: s16
type: SpeciesReference

CDMT00053
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00259
stoichiometry: 1.0
species: s105
type: SpeciesReference

CDMT00083
stoichiometry: 1.0
species: s28
type: SpeciesReference

re131
kinetic law: CDMT00304
product: CDMT00265
reactant: CDMT00264
fast: false
reversible: false
type: Reaction

s43
in compartment: c1
substance units: substance
initial concentration: NaN
boundary condition: false
name: pp-JNKK
initial amount: 0.006
has only substance units: true
constant: false
has property: MOD:00696
is version of: O14733
type: Species

k 108
units: inv nM s
value: 15700.0
type: LocalParameter

re16
type: Reaction
reversible: true
fast: false
reactant: CDMT00081
kinetic law: CDMT00084
product: CDMT00083
reactant: CDMT00082

CDMT00145
stoichiometry: 1.0
species: s48
type: SpeciesReference

re111
modifier: CDMT00196
modifier: CDMT00197
product: CDMT00195
type: Reaction
reactant: CDMT00194
kinetic law: CDMT00198
reversible: false
fast: false

CDMT00159
stoichiometry: 1.0
species: s94
type: SpeciesReference

s44
type: Species
name: pp-JNK
initial concentration: NaN
is version of: P45983
substance units: substance
in compartment: c1
boundary condition: false
constant: false
initial amount: 0.0
has property: MOD:00696
has only substance units: true

CDMT00030
stoichiometry: 1.0
species: s2
type: SpeciesReference

CDMT00245
stoichiometry: 1.0
species: s44
type: SpeciesReference

re5
fast: false
type: Reaction
modifier: CDMT00013
modifier: CDMT00012
kinetic law: CDMT00014
reversible: false
reactant: CDMT00009
modifier: CDMT00011
product: CDMT00010

CDMT00231
stoichiometry: 1.0
species: s51
type: SpeciesReference

s58
has part: P62158
initial concentration: NaN
has only substance units: true
has part: CHEBI:29108
has part: P08238
substance units: substance
initial amount: 1.037
constant: false
name: Hsp90-eNOS-CaM-Ca4
boundary condition: false
type: Species
in compartment: c1

CDMT00052
stoichiometry: 1.0
species: s50
type: SpeciesReference

K30
units: substance
value: 16.0
type: LocalParameter

CDMT00117
stoichiometry: 1.0
species: s14
type: SpeciesReference

k 105
units: inv sec
value: 1.0
type: LocalParameter

CDMT00094
stoichiometry: 1.0
species: s26
type: SpeciesReference

re132
kinetic law: CDMT00305
product: CDMT00268
product: CDMT00267
reactant: CDMT00266
fast: false
reversible: false
type: Reaction

inv subsec
unit: CDMT00281
unit: CDMT00280
name: inv_sec_sub
type: SBMLUnitsDef

K20
units: substance
value: 15.0
type: LocalParameter

CDMT00120
stoichiometry: 1.0
species: s25
type: SpeciesReference

CDMT00107
stoichiometry: 1.0
species: s28
type: SpeciesReference

CDMT00061
stoichiometry: 1.0
species: s62
type: SpeciesReference

s47
boundary condition: false
in compartment: c1
substance units: substance
has part: P62158
has only substance units: true
constant: false
initial concentration: NaN
type: Species
name: CaM-Ca4
initial amount: 2.827
has part: CHEBI:29108

CDMT00242
stoichiometry: 1.0
species: s43
type: SpeciesReference

re112
reactant: CDMT00199
fast: false
reversible: false
kinetic law: CDMT00202
modifier: CDMT00201
type: Reaction
product: CDMT00200

normal
units: sub sec
value: 0.907
type: LocalParameter

CDMT00041
stoichiometry: 1.0
species: s50
type: SpeciesReference

re17
fast: false
type: Reaction
modifier: CDMT00092
product: CDMT00091
reactant: CDMT00085
kinetic law: CDMT00093
reversible: false

K40
units: substance
value: 30.0
type: LocalParameter

CDMT00158
units: substance
value: 1.0
type: LocalParameter

Km63
units: substance
value: 8800.0
type: LocalParameter

CDMT00148
stoichiometry: 1.0
species: s95
type: SpeciesReference

tau I
constant: true
units: substance
value: 33.0
name: tau_I
type: Parameter

s57
type: Species
name: Hsp90
is version of: P08238
in compartment: c1
boundary condition: false
initial amount: 199987.0
substance units: substance
initial concentration: NaN
has only substance units: true
constant: false

re4
reactant: CDMT00005
kinetic law: CDMT00008
type: Reaction
reversible: false
modifier: CDMT00007
fast: false
product: CDMT00006

CDMT00055
stoichiometry: 1.0
species: s62
type: SpeciesReference

K CICR
constant: true
units: substance
value: 0.0
name: K_CICR
type: Parameter

CDMT00180
stoichiometry: 1.0
species: s113
type: SpeciesReference

CDMT00074
stoichiometry: 1.0
species: s17
type: SpeciesReference

CDMT00095
stoichiometry: 1.0
species: s27
type: SpeciesReference

Km62
units: substance
value: 80000.0
type: LocalParameter

kr90
constant: true
units: inv sec
value: 1.5
name: kr90
type: Parameter

K21
units: substance
value: 30.0
type: LocalParameter

re133
kinetic law: CDMT00306
product: CDMT00271
product: CDMT00270
reactant: CDMT00269
fast: false
reversible: false
type: Reaction

re113
kinetic law: CDMT00205
product: CDMT00204
reactant: CDMT00203
fast: false
reversible: false
type: Reaction

CDMT00060
stoichiometry: 1.0
species: s61
type: SpeciesReference

CDMT00040
stoichiometry: 1.0
species: s45
type: SpeciesReference

CDMT00157
units: dimensionless
value: 1.0
type: LocalParameter

re18
modifier: CDMT00096
reversible: false
fast: false
product: CDMT00095
reactant: CDMT00094
type: Reaction
kinetic law: CDMT00097

CDMT00081
stoichiometry: 1.0
species: s17
type: SpeciesReference

re3
kinetic law: CDMT00004
product: CDMT00003
reactant: CDMT00002
fast: false
reversible: false
name: re1
type: Reaction

CDMT00054
stoichiometry: 1.0
species: s60
type: SpeciesReference

CDMT00122
stoichiometry: 1.0
species: s23
type: SpeciesReference

re39
kinetic law: CDMT00247
product: CDMT00246
reactant: CDMT00245
fast: false
reversible: false
type: Reaction

CDMT00220
stoichiometry: 1.0
species: s99
type: SpeciesReference

V10
units: nM inv s
value: 154.0
type: LocalParameter

re134
kinetic law: CDMT00307
product: CDMT00287
product: CDMT00286
reactant: CDMT00285
fast: false
reversible: false
type: Reaction

CDMT00192
stoichiometry: 1.0
species: s106
type: SpeciesReference

s35
in compartment: c1
initial concentration: NaN
has only substance units: true
initial amount: 0.0
boundary condition: false
type: Species
substance units: substance
constant: false
name: s35
is: SBO:0000291

dot Vhi
constant: true
units: sub sec
value: 4760.0
name: dot_Vhi
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Nick
  family: Juty

re124
modifier: CDMT00243
reversible: false
product: CDMT00242
kinetic law: CDMT00244
fast: false
type: Reaction
reactant: CDMT00241

CDMT00077
stoichiometry: 1.0
species: s17
type: SpeciesReference

CDMT00156
units: substance
value: 60.0
type: LocalParameter

s20
has property: MOD:00696
substance units: substance
has property: IPR000403
in compartment: c1
type: Species
initial concentration: NaN
constant: false
name: p-PI3K
has only substance units: true
initial amount: 0.03
boundary condition: false

re19
type: Reaction
kinetic law: CDMT00132
product: CDMT00107
fast: false
reversible: false
modifier: CDMT00108
reactant: CDMT00098

tiny num
units: substance
value: 1.0E-6
type: LocalParameter

CDMT00121
stoichiometry: 1.0
species: s21
type: SpeciesReference

CDMT00135
stoichiometry: 1.0
species: s66
type: SpeciesReference

CDMT00221
stoichiometry: 1.0
species: s104
type: SpeciesReference

CDMT00191
stoichiometry: 1.0
species: s115
type: SpeciesReference

re135
kinetic law: CDMT00308
product: CDMT00290
product: CDMT00289
reactant: CDMT00288
fast: false
reversible: false
type: Reaction

CDMT00116
stoichiometry: 1.0
species: s25
type: SpeciesReference

dot Vex
constant: true
units: sub sec
value: 18330.0
name: dot_Vex
type: Parameter

re9
kinetic law: CDMT00039
product: CDMT00038
reactant: CDMT00037
fast: false
reversible: false
type: Reaction

CDMT00155
units: nM inv s
value: 4.0
type: LocalParameter

K43
units: substance
value: 25.0
type: LocalParameter

tc
units: substance
value: 3600.0
type: LocalParameter

CDMT00241
stoichiometry: 1.0
species: s100
type: SpeciesReference

K111
units: substance
value: 0.181
type: LocalParameter

re136
kinetic law: CDMT00309
product: CDMT00293
product: CDMT00292
reactant: CDMT00291
fast: false
reversible: false
type: Reaction

CDMT00103
stoichiometry: 1.0
species: s48
type: SpeciesReference

s23
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: Time
type: Species

s42
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 50.0
in compartment: c3
name: AP-1
type: Species

V12
units: nM inv s
value: 0.289
type: LocalParameter

CDMT00134
stoichiometry: 1.0
species: s65
type: SpeciesReference

re8
kinetic law: CDMT00036
product: CDMT00035
reactant: CDMT00034
fast: false
reversible: false
type: Reaction

s52
name: Calmodulin
in compartment: c1
boundary condition: false
type: Species
constant: false
has only substance units: true
substance units: substance
is version of: P62158
initial amount: 7635.36
initial concentration: NaN

CDMT00124
stoichiometry: 1.0
species: s64
type: SpeciesReference

uc
units: dimensionless
value: 3600.0
type: LocalParameter

CDMT00113
stoichiometry: 1.0
species: s17
type: SpeciesReference

K44
units: substance
value: 5.0
type: LocalParameter

dot q inpass
constant: true
units: sub sec
value: 6000.0
name: dot_q_inpass
type: Parameter

CDMT00051
stoichiometry: 1.0
species: s61
type: SpeciesReference

CDMT00144
stoichiometry: 1.0
species: s65
type: SpeciesReference

k21
units: inv sec
value: 0.002
type: LocalParameter

kr60
units: inv sec
value: 0.089
type: LocalParameter

s22
substance units: substance
in compartment: c1
has only substance units: true
boundary condition: false
initial concentration: NaN
constant: false
type: Species
initial amount: 99.97
has property: IPR000403
name: PI3K

CDMT00104
stoichiometry: 1.0
species: s47
type: SpeciesReference

re137
kinetic law: CDMT00310
product: CDMT00296
product: CDMT00295
reactant: CDMT00294
fast: false
reversible: false
type: Reaction

s11
name: s11
constant: false
type: Species
initial amount: 0.0
boundary condition: false
initial concentration: NaN
substance units: substance
is: SBO:0000291
has only substance units: true
in compartment: c1

CDMT00123
stoichiometry: 1.0
species: s63
type: SpeciesReference

kcat src
units: inv nM s
value: 8.33
type: LocalParameter

re7
type: Reaction
reversible: false
modifier: CDMT00032
kinetic law: CDMT00033
fast: false
reactant: CDMT00030
product: CDMT00031

s51
has only substance units: true
initial amount: 34.98
name: eNOS-Cav-1
has part: Q03135
type: Species
constant: false
initial concentration: NaN
substance units: substance
in compartment: c1
boundary condition: false

re28
kinetic law: CDMT00229
product: CDMT00228
reactant: CDMT00227
fast: false
reversible: false
type: Reaction

Kmdp
constant: true
units: substance
value: 20.0
name: Kmdp
type: Parameter

re123
kinetic law: CDMT00240
product: CDMT00239
reactant: CDMT00238
fast: false
reversible: false
type: Reaction

CDMT00114
stoichiometry: 1.0
species: s16
type: SpeciesReference

CDMT00078
stoichiometry: 1.0
species: s19
type: SpeciesReference

k38
units: inv sec
value: 0.005
type: LocalParameter

K113
units: substance
value: 10.0
type: LocalParameter

s10
name: s10
initial concentration: NaN
constant: false
initial amount: 0.0
type: Species
in compartment: c1
boundary condition: false
is: SBO:0000291
substance units: substance
has only substance units: true

Vdp
constant: true
units: sub sec
value: 4.0
name: Vdp
type: Parameter

CDMT00091
stoichiometry: 1.0
species: s26
type: SpeciesReference

CDMT00143
stoichiometry: 1.0
species: s62
type: SpeciesReference

s21
has only substance units: true
name: s3
boundary condition: false
type: Species
constant: false
in compartment: c1
initial concentration: NaN
initial amount: 0.0
is: SBO:0000291
substance units: substance

kD
units: inv sec
value: 2.8E-5
type: LocalParameter

k14
constant: true
units: inv sec
value: 1152.0
name: k14
type: Parameter

s114
has part: P29353
name: p-Shc:Grb2:Sos
type: Species
initial amount: 1.193
initial concentration: NaN
has part: Q07889
has part: P62993
substance units: substance
boundary condition: false
constant: false
in compartment: c1
has only substance units: true
has property: MOD:00696

CDMT00026
stoichiometry: 1.0
species: s45
type: SpeciesReference

CDMT00038
stoichiometry: 1.0
species: s10
type: SpeciesReference

Km58
units: substance
value: 6170.0
type: LocalParameter

CDMT00068
stoichiometry: 1.0
species: s22
type: SpeciesReference

s61
has part: CHEBI:29108
initial concentration: NaN
substance units: substance
in compartment: c1
has part: P08238
name: Hsp90-eNOS-CaM-Ca2
boundary condition: false
has part: P62158
has only substance units: true
initial amount: 10.98
constant: false
type: Species

kP
units: nM inv s
value: 0.02824
type: LocalParameter

CDMT00058
stoichiometry: 1.0
species: s60
type: SpeciesReference

k1
constant: true
units: sub sec
value: 0.0012
name: k1
type: Parameter

s108
initial concentration: NaN
has only substance units: true
substance units: substance
boundary condition: false
in compartment: c3
constant: false
initial amount: 0.0
is version of: http://identifiers.org/ncbigene/4846
type: Species
is: SBO:0000243
name: eNOS

k66
units: inv subsec
value: 7.0E-4
type: LocalParameter

unitime
units: sub sec
value: 1.0
type: LocalParameter

K cam no
units: inv sec
value: 17.0
type: LocalParameter

CDMT00150
stoichiometry: 1.0
species: s93
type: SpeciesReference

CDMT00049
stoichiometry: 1.0
species: s61
type: SpeciesReference

k111
units: inv sec
value: 0.222
type: LocalParameter

k13
constant: true
units: inv subsec
value: 0.08
name: k13
type: Parameter

s113
in compartment: c1
has only substance units: true
has part: Q05397
has property: MOD:00696
has part: Q07889
type: Species
substance units: substance
initial amount: 5.577
constant: false
initial concentration: NaN
has part: P29353
has part: P62993
boundary condition: false
name: p-FAK:p-Shc:Grb2:Sos

CDMT00164
units: nM inv s
value: 0.026
type: LocalParameter

CDMT00027
stoichiometry: 1.0
species: s45
type: SpeciesReference

Km59
units: substance
value: 80.9
type: LocalParameter

s62
boundary condition: false
has property: MOD:00696
has part: CHEBI:29108
initial concentration: NaN
has only substance units: true
substance units: substance
in compartment: c1
has part: P08238
constant: false
type: Species
has part: P62158
initial amount: 0.106
name: Hsp90-p-eNOS-CaM-Ca2

k65
units: inv sec
value: 0.163
type: LocalParameter

CDMT00069
stoichiometry: 1.0
species: s20
type: SpeciesReference

s107
type: Species
boundary condition: false
name: aAP-1
substance units: substance
in compartment: c3
initial concentration: NaN
constant: false
has property: MOD:00000
initial amount: 0.0
has only substance units: true

CDMT00024
stoichiometry: 1.0
species: s51
type: SpeciesReference

k12
constant: true
units: inv sec
value: 10.3
name: k12
type: Parameter

K19
units: substance
value: 15.0
type: LocalParameter

s116
constant: false
in compartment: c1
substance units: substance
is: SBO:0000291
boundary condition: false
initial amount: 0.0
name: sa49_degraded
has only substance units: true
initial concentration: NaN
type: Species

half
constant: true
units: dimensionless
value: 0.5
name: half
type: Parameter

k64
units: inv sec
value: 0.04
type: LocalParameter

K18
units: substance
value: 8.0
type: LocalParameter

K39
units: substance
value: 15.0
type: LocalParameter

s106
is encoded by: http://identifiers.org/ncbigene/4846
has only substance units: true
substance units: substance
is: SBO:0000278
boundary condition: false
in compartment: c1
initial amount: 3.214
constant: false
name: eNOS
type: Species
initial concentration: NaN

k11
constant: true
units: inv subsec
value: 0.004
name: k11
type: Parameter

CDMT00015
stoichiometry: 1.0
species: s6
type: SpeciesReference

sub sec
unit: CDMT00278
unit: CDMT00277
name: sub_sec
type: SBMLUnitsDef

CDMT00037
stoichiometry: 1.0
species: s3
type: SpeciesReference

k43
units: inv sec
value: 4.0E-5
type: LocalParameter

CDMT00025
stoichiometry: 1.0
species: s47
type: SpeciesReference

s115
is encoded by: http://identifiers.org/ncbigene/4846
has only substance units: true
type: Species
name: eNOS
initial amount: 0.09
substance units: substance
constant: false
in compartment: c3
initial concentration: NaN
boundary condition: false
is: SBO:0000278

k63
units: inv sec
value: 0.037
type: LocalParameter

s60
type: Species
initial concentration: NaN
constant: false
in compartment: c1
boundary condition: false
has part: P62158
has property: MOD:00696
has part: CHEBI:29108
has only substance units: true
substance units: substance
initial amount: 0.0089
has part: P08238
name: Hsp90-p-eNOS-CaM-Ca4

time
unit: CDMT00272
name: time
type: SBMLUnitsDef

s105
boundary condition: false
constant: false
in compartment: c1
initial amount: 0.0
type: Species
substance units: substance
is: SBO:0000278
name: KLF2
initial concentration: NaN
encodes: Q9Y5W3
has only substance units: true

CDMT00057
stoichiometry: 1.0
species: s58
type: SpeciesReference

s50
initial amount: 2.12
has part: CHEBI:29108
constant: false
in compartment: c1
initial concentration: NaN
type: Species
boundary condition: false
name: eNOS-CaM-Ca2
has part: P62158
has only substance units: true
substance units: substance

K38
units: substance
value: 15.0
type: LocalParameter

K1
constant: true
units: substance
value: 0.0
name: K1
type: Parameter

s118
in compartment: c1
initial amount: 0.0
is: SBO:0000291
type: Species
substance units: substance
boundary condition: false
constant: false
has only substance units: true
initial concentration: NaN
name: s118

k18
constant: true
units: inv sec
value: 1.5
name: k18
type: Parameter

CDMT00034
stoichiometry: 1.0
species: s3
type: SpeciesReference

Km64
units: substance
value: 48000.0
type: LocalParameter

CDMT00022
stoichiometry: 1.0
species: s9
type: SpeciesReference

K37
units: substance
value: 15.0
type: LocalParameter

s104
has property: MOD:00696
initial amount: 0.003
has only substance units: true
substance units: substance
in compartment: c1
boundary condition: false
constant: false
name: p-JNK
is version of: P45983
type: Species
initial concentration: NaN

CDMT00002
stoichiometry: 1.0
species: s4
type: SpeciesReference

k19
units: inv sec
value: 0.005
type: LocalParameter

CDMT00160
stoichiometry: 1.0
species: s92
type: SpeciesReference

s117
in compartment: c1
initial amount: 0.0
substance units: substance
type: Species
is: SBO:0000291
name: s117
boundary condition: false
constant: false
initial concentration: NaN
has only substance units: true

K pcam no
units: inv sec
value: 17.0
type: LocalParameter

CDMT00045
stoichiometry: 1.0
species: s58
type: SpeciesReference

CDMT00035
stoichiometry: 1.0
species: s9
type: SpeciesReference

k17
constant: true
units: inv subsec
value: 1.5E-4
name: k17
type: Parameter

substance
unit: CDMT00273
name: substance
type: SBMLUnitsDef

K2
constant: true
units: substance
value: 200.0
name: K2
type: Parameter

Km65
units: substance
value: 48000.0
type: LocalParameter

CDMT00109
stoichiometry: 1.0
species: s27
type: SpeciesReference

s103
has only substance units: true
initial amount: 119.384
in compartment: c1
boundary condition: false
has part: P01112
has part: CHEBI:17552
initial concentration: NaN
name: Ras:GDP
substance units: substance
constant: false
type: Species

CDMT00003
stoichiometry: 1.0
species: s3
type: SpeciesReference

K22
units: substance
value: 15.0
type: LocalParameter

area
unit: CDMT00274
name: area
type: SBMLUnitsDef

CDMT00140
stoichiometry: 1.0
species: s57
type: SpeciesReference

s1
is version of: CHEBI:29108
initial concentration: NaN
has only substance units: true
boundary condition: false
in compartment: default
constant: false
substance units: substance
initial amount: 1500000.0
occurs in: GO:0005576
type: Species
name: Ca_ex

CDMT00046
stoichiometry: 1.0
species: s11
type: SpeciesReference

k40
units: inv sec
value: 0.002
type: LocalParameter

CDMT00010
stoichiometry: 1.0
species: s6
type: SpeciesReference

re1
reactant: CDMT00068
type: Reaction
modifier: CDMT00070
reversible: true
modifier: CDMT00071
kinetic law: CDMT00072
product: CDMT00069
fast: false

k16
constant: true
units: inv sec
value: 0.0
name: k16
type: Parameter

s102
name: Ras:GTP
in compartment: c1
has only substance units: true
substance units: substance
boundary condition: false
initial amount: 0.616
constant: false
initial concentration: NaN
type: Species
has part: P01112
has part: CHEBI:57600

k58
units: inv sec
value: 0.2
type: LocalParameter

R T
constant: true
units: dimensionless
value: 44000.0
name: R_T
type: Parameter

s119
has only substance units: true
initial concentration: NaN
substance units: substance
type: Species
in compartment: default
constant: false
name: Shear Stress
boundary condition: false
is version of: GO:0071498
initial amount: 0.0

unisec
units: sub sec
value: 1.0
type: LocalParameter

CDMT00021
stoichiometry: 1.0
species: s3
type: SpeciesReference

re2
kinetic law: CDMT00152
product: CDMT00122
reactant: CDMT00121
fast: false
reversible: false
type: Reaction

c2
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: ER
type: Compartment

k15
constant: true
units: inv subsec
value: 0.015
name: k15
type: Parameter

CDMT00047
stoichiometry: 1.0
species: s3
type: SpeciesReference

s101
type: Species
initial amount: 1.486
boundary condition: false
is version of: Q13233
initial concentration: NaN
substance units: substance
name: p-MEKK1
has property: MOD:00696
constant: false
in compartment: c1
has only substance units: true

c1
occurs in: GO:0005623
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

k67
units: inv sec
value: 0.98
type: LocalParameter

dot Vp
constant: true
units: sub sec
value: 1630.0
name: dot_Vp
type: Parameter

K hi
constant: true
units: substance
value: 380.0
name: K_hi
type: Parameter

CDMT00006
stoichiometry: 1.0
species: s2
type: SpeciesReference

k9
units: inv sec
value: 40.8
type: LocalParameter

CDMT00296
stoichiometry: 1.0
species: s48
type: SpeciesReference

re40
reactant: CDMT00248
product: CDMT00249
type: Reaction
kinetic law: CDMT00251
fast: false
reversible: false
modifier: CDMT00250

K12
units: substance
value: 0.0571
type: LocalParameter

Vc Vs
constant: true
units: dimensionless
value: 3.5
name: Vc_Vs
type: Parameter

re30
kinetic law: CDMT00233
modifier: CDMT00232
product: CDMT00231
reactant: CDMT00230
fast: false
reversible: false
type: Reaction

CDMT00282
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00203
stoichiometry: 1.0
species: s102
type: SpeciesReference

c3
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

s100
constant: false
initial concentration: NaN
type: Species
has only substance units: true
boundary condition: false
initial amount: 0.288
is version of: O14733
has property: MOD:00696
name: p-JNKK
in compartment: c1
substance units: substance

K5
constant: true
units: substance
value: 321.0
name: K5
type: Parameter

unity
units: dimensionless
value: 1.0
type: LocalParameter

V44
units: nM inv s
value: 0.002
type: LocalParameter

s4
has only substance units: true
boundary condition: false
has part: CHEBI:29108
constant: false
initial concentration: NaN
name: Ca_B
in compartment: c1
substance units: substance
type: Species
initial amount: 3870.0
is: SBO:0000297

inv sec
unit: CDMT00279
name: inv_sec
type: SBMLUnitsDef

s96
substance units: substance
initial amount: 299.706
boundary condition: false
initial concentration: NaN
constant: false
has only substance units: true
in compartment: c1
is version of: O14733
name: JNKK
type: Species

CDMT00297
stoichiometry: 1.0
species: s58
type: SpeciesReference

k8
constant: true
units: time
value: 7.5E-5
name: k8
type: Parameter

tau II
constant: true
units: substance
value: 0.005
name: tau_II
type: Parameter

CDMT00283
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

Cao
constant: true
units: substance
value: 100.0
name: Cao
type: Parameter

CDMT00218
stoichiometry: 1.0
species: s96
type: SpeciesReference

Kmp
constant: true
units: substance
value: 5.0
name: Kmp
type: Parameter

k105
units: inv nM s
value: 0.1
type: LocalParameter

s5
constant: false
initial amount: 0.0
substance units: substance
in compartment: default
type: Species
has only substance units: true
boundary condition: false
is: SBO:0000291
name: s5
initial concentration: NaN

s95
has only substance units: true
in compartment: c1
name: FAK
substance units: substance
constant: false
is version of: Q05397
initial amount: 57.0
boundary condition: false
initial concentration: NaN
type: Species

CDMT00294
stoichiometry: 1.0
species: s62
type: SpeciesReference

CDMT00169
stoichiometry: 1.0
species: s93
type: SpeciesReference

k7
constant: true
units: inv sec
value: 300.0
name: k7
type: Parameter

s99
constant: false
name: JNK
substance units: substance
is version of: P45983
boundary condition: false
has only substance units: true
type: Species
initial amount: 299.997
initial concentration: NaN
in compartment: c1

CDMT00284
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

K10
units: substance
value: 340.0
type: LocalParameter

CDMT00303
constant: true
units: inv sec
value: 9.45E-5
name: kDD
type: Parameter

K3
constant: true
units: substance
value: 150.0
name: K3
type: Parameter

k108
units: inv sec
value: 2040.0
type: LocalParameter

CDMT00189
stoichiometry: 1.0
species: s111
type: SpeciesReference

s98
is version of: P29353
constant: false
substance units: substance
boundary condition: false
initial concentration: NaN
has only substance units: true
in compartment: c1
has property: MOD:00696
type: Species
name: p-Shc
initial amount: 157.162

nM inv s
unit: CDMT00283
unit: CDMT00282
name: nM_inv_s
type: SBMLUnitsDef

s2
has only substance units: true
boundary condition: false
initial amount: 2830000.0
name: Ca_s
constant: false
initial concentration: NaN
substance units: substance
is version of: CHEBI:29108
type: Species
in compartment: c2

CDMT00295
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00005
stoichiometry: 1.0
species: s5
type: SpeciesReference

k6
constant: true
units: inv subsec
value: 0.1
name: k6
type: Parameter

K p no
units: inv sec
value: 5.0
type: LocalParameter

B T
constant: true
units: substance
value: 120000.0
name: B_T
type: Parameter

CDMT00285
stoichiometry: 1.0
species: s66
type: SpeciesReference

CDMT00204
stoichiometry: 1.0
species: s103
type: SpeciesReference

k107
units: inv nM s
value: 60.0
type: LocalParameter

K4
constant: true
units: substance
value: 80.0
name: K4
type: Parameter

re69
modifier: CDMT00129
modifier: CDMT00130
fast: false
modifier: CDMT00126
product: CDMT00124
reactant: CDMT00123
reversible: false
modifier: CDMT00125
modifier: CDMT00127
modifier: CDMT00128
type: Reaction
modifier: CDMT00131
kinetic law: CDMT00133

s97
name: MEKK1
has only substance units: true
in compartment: c1
is version of: Q13233
constant: false
substance units: substance
initial amount: 98.514
type: Species
boundary condition: false
initial concentration: NaN

s3
is version of: CHEBI:29108
initial amount: 117.2
constant: false
substance units: substance
has only substance units: true
boundary condition: false
type: Species
in compartment: c1
name: Ca_c
initial concentration: NaN

re44
modifier: CDMT00101
reversible: true
fast: false
type: Reaction
product: CDMT00100
kinetic law: CDMT00102
reactant: CDMT00099

CDMT00167
units: substance
value: 1.0
type: LocalParameter

kT
units: inv sec
value: 0.001
type: LocalParameter

V20
units: nM inv s
value: 0.375
type: LocalParameter

ktr1
units: nM inv s
value: 1.2E-4
type: LocalParameter

CDMT00177
stoichiometry: 1.0
species: s111
type: SpeciesReference

k62
units: inv sec
value: 20.0
type: LocalParameter

CDMT00292
stoichiometry: 1.0
species: s57
type: SpeciesReference

k5
constant: true
units: inv subsec
value: 1.0E-10
name: k5
type: Parameter

s110
substance units: substance
name: p-FAK:Shc
has property: MOD:00696
in compartment: c1
constant: false
has part: Q05397
boundary condition: false
has part: P29353
has only substance units: true
type: Species
initial concentration: NaN
initial amount: 0.857

s92
constant: false
substance units: substance
in compartment: c1
boundary condition: false
is version of: P12931
has only substance units: true
type: Species
initial amount: 18.0
has property: MOD:00696
initial concentration: NaN
name: p-Src

CDMT00272
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

s8
initial amount: 0.0
has only substance units: true
boundary condition: false
is: SBO:0000291
name: s8
constant: false
substance units: substance
in compartment: c1
type: Species
initial concentration: NaN

CDMT00016
stoichiometry: 1.0
species: s8
type: SpeciesReference

re43
reversible: false
fast: false
reactant: CDMT00252
type: Reaction
product: CDMT00253
modifier: CDMT00254
kinetic law: CDMT00255

k61
units: inv sec
value: 20.0
type: LocalParameter

k4
constant: true
units: sub sec
value: 5000.0
name: k4
type: Parameter

CDMT00293
stoichiometry: 1.0
species: s48
type: SpeciesReference

CDMT00168
stoichiometry: 1.0
species: s91
type: SpeciesReference

CDMT00178
stoichiometry: 1.0
species: s113
type: SpeciesReference

s91
has only substance units: true
is version of: P29353
constant: false
substance units: substance
initial amount: 819.25
initial concentration: NaN
type: Species
in compartment: c1
name: Shc
boundary condition: false

s9
in compartment: c1
name: s9
initial concentration: NaN
constant: false
substance units: substance
has only substance units: true
boundary condition: false
is: SBO:0000291
type: Species
initial amount: 0.0

CDMT00273
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

alp
constant: true
units: time
value: 10.0
name: alp
type: Parameter

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

CDMT00165
units: substance
value: 540.0
type: LocalParameter

re56
fast: false
reactant: CDMT00060
product: CDMT00061
type: Reaction
modifier: CDMT00066
kinetic law: CDMT00067
reversible: true

k3
constant: true
units: inv sec
value: 6.64
name: k3
type: Parameter

kp
constant: true
units: inv sec
value: 0.1
name: kp
type: Parameter

k60
units: inv subsec
value: 0.045
type: LocalParameter

s6
has only substance units: true
boundary condition: false
initial amount: 0.0
name: IP3
is version of: CHEBI:203600
substance units: substance
in compartment: c1
constant: false
initial concentration: NaN
type: Species

CDMT00270
stoichiometry: 1.0
species: s117
type: SpeciesReference

W3 CDTF: Mon Aug 19 14:38:04 BST 2013

s112
initial amount: 15.962
has only substance units: true
has part: Q05397
type: Species
initial concentration: NaN
constant: false
in compartment: c1
name: p-FAK:p-Shc
has part: P29353
substance units: substance
boundary condition: false
has property: MOD:00696

CDMT00290
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00028
stoichiometry: 1.0
species: s57
type: SpeciesReference

s94
substance units: substance
boundary condition: false
in compartment: c1
is version of: P12931
has only substance units: true
type: Species
name: Src
initial amount: 72.0
initial concentration: NaN
constant: false

CDMT00280
exponent: -1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

CDMT00018
stoichiometry: 1.0
species: s13
type: SpeciesReference

CDMT00260
stoichiometry: 1.0
species: s49
type: SpeciesReference

CDMT00281
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

re45
type: Reaction
kinetic law: CDMT00106
product: CDMT00104
reactant: CDMT00103
fast: false
modifier: CDMT00105
reversible: false

CDMT00166
units: dimensionless
value: 1.0
type: LocalParameter

s111
constant: false
initial concentration: NaN
in compartment: c1
has part: P62993
type: Species
boundary condition: false
has part: Q07889
substance units: substance
initial amount: 3.23
name: Grb2:Sos
has only substance units: true

CDMT00009
stoichiometry: 1.0
species: s7
type: SpeciesReference

k2
constant: true
units: inv sec
value: 2.0
name: k2
type: Parameter

re55
modifier: CDMT00059
reversible: true
reactant: CDMT00057
product: CDMT00058
kinetic law: CDMT00065
type: Reaction
fast: false

CDMT00200
stoichiometry: 1.0
species: s102
type: SpeciesReference

CDMT00271
stoichiometry: 1.0
species: s48
type: SpeciesReference

s7
name: s7
initial concentration: NaN
substance units: substance
constant: false
has only substance units: true
boundary condition: false
type: Species
is: SBO:0000291
in compartment: c1
initial amount: 0.0

k113
units: inv sec
value: 0.035
type: LocalParameter

CDMT00029
stoichiometry: 1.0
species: s58
type: SpeciesReference

s93
boundary condition: false
in compartment: c1
has only substance units: true
constant: false
initial amount: 0.605
substance units: substance
name: p-FAK
has property: MOD:00696
initial concentration: NaN
type: Species
is version of: Q05397

CDMT00291
stoichiometry: 1.0
species: s61
type: SpeciesReference

k CICR
constant: true
units: dimensionless
value: 1.0
name: k_CICR
type: Parameter

CDMT00019
stoichiometry: 1.0
species: s12
type: SpeciesReference

given: Vijayalakshmi
family: Chelliah

orgname: EMBL-EBI

W3 CDTF: Thu Oct 10 15:20:43 BST 2013