s64
type: Species
boundary condition: false
is version of: CHEBI:16480
initial amount: 0.0
in compartment: c1
initial concentration: NaN
name: NO
constant: false
has only substance units: true
substance units: substance

CDMT00284
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

CDMT00145
stoichiometry: 1.0
species: s48
type: SpeciesReference

kCaM
units: inv sec
value: 17.0
type: LocalParameter

re55
reversible: true
fast: false
modifier: CDMT00059
kinetic law: CDMT00065
type: Reaction
product: CDMT00058
reactant: CDMT00057

s3
type: Species
name: Ca_c
initial amount: 117.2
in compartment: c1
occurs in: GO:0005623
boundary condition: true
substance units: substance
is: CHEBI:29108
constant: true
initial concentration: NaN
has only substance units: true

inv nM s
unit: CDMT00313
unit: CDMT00284
name: inv_nM_s
type: SBMLUnitsDef

CDMT00270
stoichiometry: 1.0
species: s117
type: SpeciesReference

CDMT00298
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00045
stoichiometry: 1.0
species: s58
type: SpeciesReference

CDMT00283
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

k18
constant: true
units: inv sec
value: 1.5
name: k3r
type: Parameter

s65
initial amount: 0.643
boundary condition: false
name: Hsp90-p-eNOS
has part: P08238
type: Species
initial concentration: NaN
substance units: substance
has only substance units: true
is: SBO:0000297
constant: false
in compartment: c1
has property: MOD:00696

CDMT00144
stoichiometry: 1.0
species: s65
type: SpeciesReference

re56
modifier: CDMT00066
reversible: true
reactant: CDMT00060
product: CDMT00061
fast: false
type: Reaction
kinetic law: CDMT00067

CDMT00297
stoichiometry: 1.0
species: s58
type: SpeciesReference

inv subsec
unit: CDMT00281
unit: CDMT00280
name: inv_sec_sub
type: SBMLUnitsDef

s52
substance units: substance
boundary condition: false
type: Species
initial amount: 7635.36
in compartment: c1
constant: false
initial concentration: NaN
has only substance units: true
is version of: P62158
name: Calmodulin

CDMT00272
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

k17
constant: true
units: inv subsec
value: 1.5E-4
name: k3
type: Parameter

CDMT00269
stoichiometry: 1.0
species: s50
type: SpeciesReference

s66
substance units: substance
type: Species
initial amount: 0.083
is: SBO:0000297
boundary condition: false
constant: false
in compartment: c1
initial concentration: NaN
name: Hsp90-eNOS
has only substance units: true
has part: P08238

CDMT00282
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

substance
unit: CDMT00273
name: substance
type: SBMLUnitsDef

re53
kinetic law: CDMT00063
product: CDMT00053
product: CDMT00052
reactant: CDMT00051
fast: false
reversible: false
type: Reaction

CDMT00301
stoichiometry: 1.0
species: s57
type: SpeciesReference

kr90
constant: true
units: inv sec
value: 1.5
name: k7
type: Parameter

CDMT00271
stoichiometry: 1.0
species: s48
type: SpeciesReference

CDMT00099
stoichiometry: 1.0
species: s52
type: SpeciesReference

re54
modifier: CDMT00056
reversible: true
reactant: CDMT00054
product: CDMT00055
fast: false
kinetic law: CDMT00064
type: Reaction

CDMT00281
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00300
stoichiometry: 1.0
species: s60
type: SpeciesReference

CDMT00104
stoichiometry: 1.0
species: s47
type: SpeciesReference

CDMT00299
stoichiometry: 1.0
species: s47
type: SpeciesReference

s60
type: Species
initial concentration: NaN
has property: MOD:00696
has property: CHEBI:29108
initial amount: 0.0089
name: Hsp90-p-eNOS-CaM-Ca4
boundary condition: false
constant: false
in compartment: c1
has property: P08238
is: SBO:0000297
has only substance units: true
substance units: substance
has property: P62158

CDMT00288
stoichiometry: 1.0
species: s65
type: SpeciesReference

s50
type: Species
constant: false
has part: P62158
initial concentration: NaN
is: SBO:0000297
boundary condition: false
name: eNOS-CaM-Ca2
in compartment: c1
has only substance units: true
initial amount: 2.12
has part: CHEBI:29108
substance units: substance

CDMT00267
stoichiometry: 1.0
species: s117
type: SpeciesReference

CDMT00274
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

CDMT00294
stoichiometry: 1.0
species: s62
type: SpeciesReference

CDMT00303
constant: true
units: inv sec
value: 9.45E-5
name: kD
type: Parameter

default
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

re51
kinetic law: CDMT00044
product: CDMT00029
reactant: CDMT00027
reactant: CDMT00028
reversible: false
fast: false
type: Reaction

s27
boundary condition: false
has part: P31749
constant: false
initial amount: 1.723
type: Species
name: pp-AKT:PI3P
in compartment: c1
initial concentration: NaN
substance units: substance
has only substance units: true
has part: http://identifiers.org/pubchem.compound/53480352
has property: MOD:00696

CDMT00060
stoichiometry: 1.0
species: s61
type: SpeciesReference

CDMT00268
stoichiometry: 1.0
species: s47
type: SpeciesReference

s61
has part: P62158
type: Species
substance units: substance
boundary condition: false
has part: P08238
initial amount: 10.98
constant: false
has only substance units: true
name: Hsp90-eNOS-CaM-Ca2
is: SBO:0000297
in compartment: c1
initial concentration: NaN
has part: CHEBI:29108

CDMT00287
stoichiometry: 1.0
species: s118
type: SpeciesReference

time
unit: CDMT00272
name: time
type: SBMLUnitsDef

s51
is: SBO:0000297
in compartment: c1
initial concentration: NaN
has part: Q03135
boundary condition: false
is version of: GO:0051001
initial amount: 34.98
substance units: substance
type: Species
constant: false
name: eNOS-Cav-1
has only substance units: true

CDMT00041
stoichiometry: 1.0
species: s50
type: SpeciesReference

CDMT00273
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

s116
initial amount: 0.0
type: Species
name: sa49_degraded
boundary condition: false
in compartment: c1
substance units: substance
constant: false
has only substance units: true
initial concentration: NaN
is: SBO:0000291

CDMT00293
stoichiometry: 1.0
species: s48
type: SpeciesReference

CDMT00302
stoichiometry: 1.0
species: s47
type: SpeciesReference

re52
kinetic law: CDMT00062
fast: false
reactant: CDMT00045
reversible: true
product: CDMT00049
modifier: CDMT00050
type: Reaction

inv sec
unit: CDMT00279
name: inv_sec
type: SBMLUnitsDef

CDMT00286
stoichiometry: 1.0
species: s57
type: SpeciesReference

s62
has part: P08238
initial concentration: NaN
has property: MOD:00696
initial amount: 0.106
constant: false
has part: P62158
is: SBO:0000297
boundary condition: false
in compartment: c1
name: Hsp90-p-eNOS-CaM-Ca2
has part: CHEBI:29108
has only substance units: true
substance units: substance
type: Species

BIOMD0000000467
units def: inv nM s
reaction: re131
reaction: re134
reaction: re50
parameter: Kmdp
is version of: GO:0006809
parameter: k90
parameter: k5
substance units: substance
reaction: re53
reaction: re56
species: s47
parameter: k14
compartment: default
occurs in: http://identifiers.org/taxonomy/9606
is version of: REACT 12443.3
reaction: re37
volume units: volume
area units: area
species: s118
time units: time
species: s27
species: s63
parameter: k11
curated: true
reaction: re132
species: s62
reaction: re72
length unit: length
parameter: k17
units def: sub sec
reaction: re135
reaction: re51
reaction: re54
species: s45
species: s52
parameter: CDMT00303
parameter: k12
units def: substance
parameter: k15
units def: volume
reaction: re70
species: s3
reaction: re69
species: s116
reaction: re38
species: s66
compartment: c1
species: s117
species: s61
species: s51
units def: area
type: SBMLModel
species: s60
reaction: re139
reaction: re44
reaction: re45
name: Koo2013 - Shear stress induced NO production - Model 4
reaction: re137
parameter: Vdp
units def: length
reaction: re133
reaction: re136
reaction: re52
parameter: k13
units def: time
parameter: k18
reaction: re71
species: s58
species: s48
species: s65
units def: inv sec
species: s57
reaction: re55
species: s64
parameter: kr90
parameter: Kmp
units def: inv subsec
units def: nM inv s
is: MODEL1302180006

s117
boundary condition: false
initial amount: 0.0
is: SBO:0000291
name: s117
has only substance units: true
type: Species
initial concentration: NaN
constant: false
substance units: substance
in compartment: c1

CDMT00265
stoichiometry: 1.0
species: s116
type: SpeciesReference

CDMT00040
stoichiometry: 1.0
species: s45
type: SpeciesReference

CDMT00276
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

CDMT00296
stoichiometry: 1.0
species: s48
type: SpeciesReference

nM inv s
unit: CDMT00283
unit: CDMT00282
name: nM_inv_s
type: SBMLUnitsDef

k90
constant: true
units: inv subsec
value: 0.002
name: k6
type: Parameter

s63
has only substance units: true
substance units: substance
is version of: CHEBI:16467
initial amount: 500000.0
in compartment: c1
is: SBO:0000291
name: L-Arg
type: Species
constant: false
boundary condition: false
initial concentration: NaN

CDMT00285
stoichiometry: 1.0
species: s66
type: SpeciesReference

s118
type: Species
constant: false
boundary condition: false
substance units: substance
in compartment: c1
is: SBO:0000291
has only substance units: true
name: s118
initial concentration: NaN
initial amount: 0.0

CDMT00266
stoichiometry: 1.0
species: s45
type: SpeciesReference

CDMT00275
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

re44
kinetic law: CDMT00102
modifier: CDMT00101
fast: false
type: Reaction
reactant: CDMT00099
product: CDMT00100
reversible: true

CDMT00295
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00061
stoichiometry: 1.0
species: s62
type: SpeciesReference

re50
type: Reaction
modifier: CDMT00043
kinetic law: CDMT00042
fast: false
product: CDMT00041
reversible: true
reactant: CDMT00040

CDMT00026
stoichiometry: 1.0
species: s45
type: SpeciesReference

re135
kinetic law: CDMT00308
product: CDMT00290
product: CDMT00289
reactant: CDMT00288
fast: false
reversible: false
type: Reaction

CDMT00138
stoichiometry: 1.0
species: s66
type: SpeciesReference

re45
product: CDMT00104
kinetic law: CDMT00106
type: Reaction
reversible: false
fast: false
reactant: CDMT00103
modifier: CDMT00105

CDMT00124
stoichiometry: 1.0
species: s64
type: SpeciesReference

CDMT00053
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00278
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

k10
constant: true
units: inv sec
value: 0.1
name: k10
type: Parameter

sub sec
unit: CDMT00278
unit: CDMT00277
name: sub_sec
type: SBMLUnitsDef

re136
kinetic law: CDMT00309
product: CDMT00293
product: CDMT00292
reactant: CDMT00291
fast: false
reversible: false
type: Reaction

CDMT00025
stoichiometry: 1.0
species: s47
type: SpeciesReference

CDMT00277
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

length
unit: CDMT00275
name: length
type: SBMLUnitsDef

CDMT00054
stoichiometry: 1.0
species: s60
type: SpeciesReference

CDMT00139
stoichiometry: 1.0
species: s51
type: SpeciesReference

kp
units: inv sec
value: 5.0
type: LocalParameter

CDMT00290
stoichiometry: 1.0
species: s57
type: SpeciesReference

k11
constant: true
units: inv subsec
value: 0.004
name: k1
type: Parameter

CDMT00264
stoichiometry: 1.0
species: s51
type: SpeciesReference

k5
constant: true
units: inv sec
value: 115.2
name: k5
type: Parameter

re133
kinetic law: CDMT00306
product: CDMT00271
product: CDMT00270
reactant: CDMT00269
fast: false
reversible: false
type: Reaction

CDMT00024
stoichiometry: 1.0
species: s51
type: SpeciesReference

re72
product: CDMT00145
reversible: true
kinetic law: CDMT00147
type: Reaction
product: CDMT00144
fast: false
reactant: CDMT00143

CDMT00291
stoichiometry: 1.0
species: s61
type: SpeciesReference

re71
kinetic law: CDMT00142
product: CDMT00140
product: CDMT00139
reactant: CDMT00138
fast: false
reversible: false
type: Reaction

CDMT00051
stoichiometry: 1.0
species: s61
type: SpeciesReference

kpCaM
units: inv sec
value: 17.0
type: LocalParameter

re134
kinetic law: CDMT00307
product: CDMT00287
product: CDMT00286
reactant: CDMT00285
fast: false
reversible: false
type: Reaction

re70
kinetic law: CDMT00137
product: CDMT00135
reactant: CDMT00134
fast: false
reversible: false
type: Reaction

CDMT00292
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00052
stoichiometry: 1.0
species: s50
type: SpeciesReference

volume
unit: CDMT00276
name: volume
type: SBMLUnitsDef

CDMT00289
stoichiometry: 1.0
species: s118
type: SpeciesReference

CDMT00279
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00100
stoichiometry: 1.0
species: s48
type: SpeciesReference

re131
kinetic law: CDMT00304
product: CDMT00265
reactant: CDMT00264
fast: false
reversible: false
type: Reaction

s48
initial concentration: NaN
has only substance units: true
in compartment: c1
has part: CHEBI:29108
is: SBO:0000297
name: CaM-Ca2
constant: false
type: Species
has part: P62158
boundary condition: false
substance units: substance
initial amount: 347.52

s58
type: Species
has part: P08238
is: SBO:0000297
constant: false
initial amount: 1.037
substance units: substance
name: Hsp90-eNOS-CaM-Ca4
has part: P62158
boundary condition: false
initial concentration: NaN
in compartment: c1
has part: CHEBI:29108
has only substance units: true

CDMT00087
stoichiometry: 1.0
species: s48
type: SpeciesReference

re69
kinetic law: CDMT00133
type: Reaction
modifier: CDMT00130
modifier: CDMT00129
modifier: CDMT00127
reversible: false
modifier: CDMT00131
modifier: CDMT00125
product: CDMT00124
reactant: CDMT00123
modifier: CDMT00128
fast: false
modifier: CDMT00126

k14
constant: true
units: inv sec
value: 1152.0
name: k2r
type: Parameter

CDMT00134
stoichiometry: 1.0
species: s65
type: SpeciesReference

re139
kinetic law: CDMT00312
product: CDMT00302
product: CDMT00301
reactant: CDMT00300
fast: false
reversible: false
type: Reaction

c1
is: GO:0005623
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

area
unit: CDMT00274
name: area
type: SBMLUnitsDef

Kmp
constant: true
units: substance
value: 5.0
name: Km10
type: Parameter

CDMT00057
stoichiometry: 1.0
species: s58
type: SpeciesReference

CDMT00313
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

s47
substance units: substance
name: CaM-Ca4
has part: P62158
boundary condition: false
in compartment: c1
has part: CHEBI:29108
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: 2.827
has only substance units: true
type: Species

re132
kinetic law: CDMT00305
product: CDMT00268
product: CDMT00267
reactant: CDMT00266
fast: false
reversible: false
type: Reaction

CDMT00029
stoichiometry: 1.0
species: s58
type: SpeciesReference

CDMT00088
stoichiometry: 1.0
species: s51
type: SpeciesReference

CDMT00280
exponent: -1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

s57
has only substance units: true
is version of: P08238
constant: false
in compartment: c1
boundary condition: false
initial amount: 199987.0
initial concentration: NaN
name: Hsp90
type: Species
substance units: substance

k15
constant: true
units: inv subsec
value: 0.015
name: k4
type: Parameter

CDMT00049
stoichiometry: 1.0
species: s61
type: SpeciesReference

CDMT00140
stoichiometry: 1.0
species: s57
type: SpeciesReference

CDMT00135
stoichiometry: 1.0
species: s66
type: SpeciesReference

CDMT00058
stoichiometry: 1.0
species: s60
type: SpeciesReference

re137
kinetic law: CDMT00310
product: CDMT00296
product: CDMT00295
reactant: CDMT00294
fast: false
reversible: false
type: Reaction

CDMT00089
stoichiometry: 1.0
species: s50
type: SpeciesReference

CDMT00028
stoichiometry: 1.0
species: s57
type: SpeciesReference

k12
constant: true
units: inv sec
value: 10.3
name: k1r
type: Parameter

CDMT00143
stoichiometry: 1.0
species: s62
type: SpeciesReference

CDMT00055
stoichiometry: 1.0
species: s62
type: SpeciesReference

re37
kinetic law: CDMT00086
type: Reaction
reactant: CDMT00024
reversible: false
reactant: CDMT00025
product: CDMT00026
fast: false

s45
type: Species
substance units: substance
constant: false
has part: P62158
boundary condition: false
in compartment: c1
has part: CHEBI:29108
initial amount: 0.0415
name: eNOS-CaM-Ca4
initial concentration: NaN
has only substance units: true
is: SBO:0000297

CDMT00103
stoichiometry: 1.0
species: s48
type: SpeciesReference

re138
kinetic law: CDMT00311
product: CDMT00299
product: CDMT00298
reactant: CDMT00297
fast: false
reversible: false
type: Reaction

CDMT00027
stoichiometry: 1.0
species: s45
type: SpeciesReference

Vdp
constant: true
units: sub sec
value: 4.0
name: V10r
type: Parameter

k13
constant: true
units: inv subsec
value: 0.08
name: k2
type: Parameter

Kmdp
constant: true
units: substance
value: 20.0
name: Km10r
type: Parameter

re38
reactant: CDMT00088
type: Reaction
kinetic law: CDMT00090
product: CDMT00089
fast: false
reversible: true
reactant: CDMT00087

CDMT00123
stoichiometry: 1.0
species: s63
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Mon Aug 19 14:37:06 BST 2013

orgname: Massachusetts Institute of Technology

given: Andrew
family: Koo

ORG:
  orgname: EMBL-EBI
n:
  given: Nick
  family: Juty

W3 CDTF: Thu Oct 10 15:22:04 BST 2013