dot Vp
constant: true
units: sub sec
value: 815.0
name: dot_Vp
type: Parameter

CDMT00009
stoichiometry: 1.0
species: s7
type: SpeciesReference

s119
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: Shear Stress
type: Species

dot q inpass
constant: true
units: sub sec
value: 3000.0
name: dot_q_inpass
type: Parameter

CDMT00005
stoichiometry: 1.0
species: s5
type: SpeciesReference

tau II
constant: true
units: substance
value: 0.01
name: tau_II
type: Parameter

re6
kinetic law: CDMT00017
product: CDMT00016
reactant: CDMT00015
fast: false
reversible: false
type: Reaction

c2
is: GO:0005783
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: ER
type: Compartment

CDMT00046
stoichiometry: 1.0
species: s11
type: SpeciesReference

CDMT00277
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

s3
initial amount: 117.2
has only substance units: true
constant: false
occurs in: GO:0005623
boundary condition: false
substance units: substance
type: Species
initial concentration: NaN
name: Ca_c
is: CHEBI:29108
in compartment: c1

k CICR
constant: true
units: dimensionless
value: 1.0
name: k_CICR
type: Parameter

k1
constant: true
units: sub sec
value: 6.0E-4
name: k1
type: Parameter

dot Vex
constant: true
units: sub sec
value: 9165.0
name: dot_Vex
type: Parameter

inv subsec
unit: CDMT00281
unit: CDMT00280
name: inv_sec_sub
type: SBMLUnitsDef

re5
modifier: CDMT00012
modifier: CDMT00013
fast: false
modifier: CDMT00011
type: Reaction
kinetic law: CDMT00014
reactant: CDMT00009
product: CDMT00010
reversible: false

K CICR
constant: true
units: substance
value: 0.0
name: K_CICR
type: Parameter

Cao
constant: true
units: substance
value: 100.0
name: Cao
type: Parameter

K5
constant: true
units: substance
value: 321.0
name: K5
type: Parameter

c1
is: GO:0005623
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

BIOMD0000000464
units def: length
parameter: k CICR
species: s1
parameter: dot Vex
created:
  W3 CDTF: Mon Aug 19 14:33:57 BST 2013
reaction: re12
units def: sub sec
parameter: Cao
parameter: K3
units def: time
species: s11
parameter: k1
parameter: dot Vhi
compartment: c2
parameter: k4
units def: nM inv s
reaction: re8
reaction: re4
parameter: tau I
species: s10
species: s9
species: s119
units def: inv sec
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
species: s5
reaction: re10
parameter: k CCE
parameter: K1
is version of: GO:0006809
parameter: B T
area units: area
curated: true
parameter: k6
parameter: tau II
has part: REACT 12443.3
compartment: c1
parameter: K hi
units def: substance
units def: inv nM s
parameter: K4
reaction: re5
parameter: K CICR
units def: inv subsec
reaction: re9
parameter: dot q inpass
has part: GO:0070509
species: s8
parameter: R T
parameter: k5
species: s4
substance units: substance
length unit: length
parameter: k2
parameter: half
species: s7
units def: area
species: s3
type: SBMLModel
parameter: K2
is: MODEL1302180003
parameter: K5
reaction: re11
species: s13
compartment: default
units def: volume
occurs in: http://identifiers.org/taxonomy/9606
time units: time
name: Koo2013 - Shear stress induced calcium influx and eNOS activation - Model 1
parameter: k7
parameter: fracK
reaction: re6
species: s12
parameter: dot Vp
reaction: re3
reaction: re7
species: s6
parameter: k3
species: s2
volume units: volume
is described by: http://identifiers.org/pubmed/23708369

CDMT00047
stoichiometry: 1.0
species: s3
type: SpeciesReference

s2
boundary condition: false
name: Ca_s
constant: false
initial concentration: NaN
is: CHEBI:29108
has only substance units: true
initial amount: 2830000.0
in compartment: c2
substance units: substance
type: Species

CDMT00276
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

inv sec
unit: CDMT00279
name: inv_sec
type: SBMLUnitsDef

k7
constant: true
units: inv sec
value: 150.0
name: k7
type: Parameter

re11
kinetic law: CDMT00020
product: CDMT00019
reactant: CDMT00018
fast: false
reversible: false
type: Reaction

CDMT00034
stoichiometry: 1.0
species: s3
type: SpeciesReference

half
constant: true
units: dimensionless
value: 0.5
name: half
type: Parameter

K4
constant: true
units: substance
value: 80.0
name: K4
type: Parameter

re4
modifier: CDMT00007
kinetic law: CDMT00008
fast: false
reactant: CDMT00005
reversible: false
product: CDMT00006
type: Reaction

CDMT00280
exponent: -1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

s5
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s5
type: Species

CDMT00275
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

nM inv s
unit: CDMT00283
unit: CDMT00282
name: nM_inv_s
type: SBMLUnitsDef

s10
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: s10
type: Species

dot Vhi
constant: true
units: sub sec
value: 2380.0
name: dot_Vhi
type: Parameter

re12
kinetic law: CDMT00023
product: CDMT00022
reactant: CDMT00021
fast: false
reversible: false
type: Reaction

CDMT00006
stoichiometry: 1.0
species: s2
type: SpeciesReference

time
unit: CDMT00272
name: time
type: SBMLUnitsDef

CDMT00035
stoichiometry: 1.0
species: s9
type: SpeciesReference

B T
constant: true
units: substance
value: 120000.0
name: B_T
type: Parameter

K3
constant: true
units: substance
value: 150.0
name: K3
type: Parameter

re3
reactant: CDMT00002
name: re1
product: CDMT00003
fast: false
kinetic law: CDMT00004
reversible: false
type: Reaction

s4
initial amount: 3870.0
boundary condition: false
name: Ca_B
constant: false
in compartment: c1
has part: CHEBI:29108
initial concentration: NaN
has only substance units: true
type: Species
occurs in: GO:0005623
substance units: substance

CDMT00274
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

area
unit: CDMT00274
name: area
type: SBMLUnitsDef

CDMT00281
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00015
stoichiometry: 1.0
species: s6
type: SpeciesReference

k CCE
constant: true
units: inv subsec
value: 0.0
name: k_CCE
type: Parameter

CDMT00283
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00273
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: MOLE
type: SBMLUnit

K2
constant: true
units: substance
value: 200.0
name: K2
type: Parameter

CDMT00022
stoichiometry: 1.0
species: s9
type: SpeciesReference

re9
kinetic law: CDMT00039
product: CDMT00038
reactant: CDMT00037
fast: false
reversible: false
type: Reaction

s12
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: TimeT
type: Species

tau I
constant: true
units: substance
value: 66.0
name: tau_I
type: Parameter

CDMT00016
stoichiometry: 1.0
species: s8
type: SpeciesReference

substance
unit: CDMT00273
name: substance
type: SBMLUnitsDef

K hi
constant: true
units: substance
value: 380.0
name: K_hi
type: Parameter

s7
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: s7
type: Species

k4
constant: true
units: sub sec
value: 2500.0
name: k4
type: Parameter

CDMT00282
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

k6
constant: true
units: inv subsec
value: 0.05
name: k6
type: Parameter

re10
kinetic law: CDMT00048
product: CDMT00047
reactant: CDMT00046
fast: false
reversible: false
type: Reaction

CDMT00037
stoichiometry: 1.0
species: s3
type: SpeciesReference

CDMT00272
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

K1
constant: true
units: substance
value: 0.0
name: K1
type: Parameter

s11
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: s11
type: Species

k5
constant: true
units: inv subsec
value: 5.0E-11
name: k5
type: Parameter

s6
name: IP3
initial amount: 0.0
constant: false
substance units: substance
in compartment: c1
has only substance units: true
initial concentration: NaN
is version of: CHEBI:203600
boundary condition: false
type: Species

CDMT00010
stoichiometry: 1.0
species: s6
type: SpeciesReference

inv nM s
unit: CDMT00313
unit: CDMT00284
name: inv_nM_s
type: SBMLUnitsDef

CDMT00279
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

CDMT00003
stoichiometry: 1.0
species: s3
type: SpeciesReference

CDMT00030
stoichiometry: 1.0
species: s2
type: SpeciesReference

s1
in compartment: default
initial amount: 1500000.0
substance units: substance
name: Ca_ex
constant: false
initial concentration: NaN
occurs in: GO:0005576
has only substance units: true
is: CHEBI:29108
boundary condition: false
type: Species

re7
product: CDMT00031
kinetic law: CDMT00033
reactant: CDMT00030
modifier: CDMT00032
type: Reaction
fast: false
reversible: false

CDMT00038
stoichiometry: 1.0
species: s10
type: SpeciesReference

volume
unit: CDMT00276
name: volume
type: SBMLUnitsDef

CDMT00018
stoichiometry: 1.0
species: s13
type: SpeciesReference

CDMT00313
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

sub sec
unit: CDMT00278
unit: CDMT00277
name: sub_sec
type: SBMLUnitsDef

k2
constant: true
units: inv sec
value: 1.0
name: k2
type: Parameter

R T
constant: true
units: dimensionless
value: 44000.0
name: R_T
type: Parameter

s9
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: s9
type: Species

CDMT00002
stoichiometry: 1.0
species: s4
type: SpeciesReference

CDMT00284
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

unisec
units: sub sec
value: 1.0
type: LocalParameter

CDMT00031
stoichiometry: 1.0
species: s3
type: SpeciesReference

CDMT00278
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

re8
kinetic law: CDMT00036
product: CDMT00035
reactant: CDMT00034
fast: false
reversible: false
type: Reaction

CDMT00021
stoichiometry: 1.0
species: s3
type: SpeciesReference

s13
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: default
name: s13
type: Species

default
is: GO:0005576
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
type: Compartment

length
unit: CDMT00275
name: length
type: SBMLUnitsDef

CDMT00019
stoichiometry: 1.0
species: s12
type: SpeciesReference

s8
constant: false
boundary condition: false
has only substance units: true
substance units: substance
initial concentration: NaN
initial amount: 0.0
in compartment: c1
name: s8
type: Species

k3
constant: true
units: inv sec
value: 3.32
name: k3
type: Parameter

fracK
constant: true
units: substance
value: 7071067.81
name: fracK
type: Parameter

W3 CDTF: Thu Oct 10 15:31:59 BST 2013

orgname: Massachusetts Institute of Technology

n:
  given: Andrew
  family: Koo

ORG:
  orgname: EMBL-EBI
n:
  given: Nick
  family: Juty