Smallbone2013 - Metabolic Control Analysis - Example 3
Smallbone2013 - Metabolic Control Analysis - Example 3 Metabolic control analysis (MCA) is a biochemical formalism, defining how variables, such as fluxes and concentrations, depend on network parameters. In this paper, owing to its limitations, it is shown with three example models (MODEL1305030000-2) that the algorithm with slight modification can be applied to all models. This model is described in the article: Metabolic Control Analysis: Rereading Reder Kieran Smallbone Quantitative Methods; Tue, 28 May 2013. Abstract: Metabolic control analysis is a biochemical formalism defined by Kacser and Burns in 1973, and given firm mathematical basis by Reder in 1988. The algorithm defined by Reder for calculating the control matrices is still used by software programs today, but is only valid for some biochemical models. We show that, with slight modification, the algorithm may be applied to all models. This model is hosted on BioModels Database and identified by: MODEL1305030000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.