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value: 10.0
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876082
kinetic law: 982571
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876102
constant: true
value: 0.1
type: Parameter

876084
kinetic law: 982595
reactant: 982583
fast: false
reversible: false
type: Reaction

876100
constant: true
value: 2.0
type: Parameter

876094
constant: true
value: 40.0
type: Parameter

876078
kinetic law: 982523
product: 982511
fast: false
reversible: false
type: Reaction

876104
constant: true
value: 40.0
type: Parameter

876096
constant: false
value: NaN
type: Parameter

876076
is: SBO:0000011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
in compartment: 876072
type: Species

876110
constant: true
value: 1000.0
type: Parameter

876092
constant: true
value: 0.001
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876090
constant: true
value: 1.0E-5
type: Parameter

BIOMD0000000421
is described by: http://identifiers.org/pubmed/22531117
compartment: 876072
parameter: 876110
is version of: GO:0006355
species: 876074
parameter: 876100
reaction: 876080
rule: 876087
time units: 678679
parameter: 876096
parameter: 876090
modified:
  W3 CDTF: Wed Jul 11 19:16:35 BST 2012
curated: true
rule: 876089
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
notes: This model is from the article: Asymmetric positive feedback loops reliably control biological responses Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison Mol Syst Biol. 2012 Apr 24;8:577. 22531117 , Abstract: Positive feedback is a common mechanism enabling biological systems to respond to stimuli in a switch-like manner. Such systems are often characterized by the requisite formation of a heterodimer where only one of the pair is subject to feedback. This ASymmetric Self-UpREgulation (ASSURE) motif is central to many biological systems, including cholesterol homeostasis (LXRα/RXRα), adipocyte differentiation (PPARγ/RXRα), development and differentiation (RAR/RXR), myogenesis (MyoD/E12) and cellular antiviral defense (IRF3/IRF7). To understand why this motif is so prevalent, we examined its properties in an evolutionarily conserved transcriptional regulatory network in yeast (Oaf1p/Pip2p). We demonstrate that the asymmetry in positive feedback confers a competitive advantage and allows the system to robustly increase its responsiveness while precisely tuning the response to a consistent level in the presence of varying stimuli. This study reveals evolutionary advantages for the ASSURE motif, and mechanisms for control, that are relevant to pharmacologic intervention and synthetic biology applications. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, La…
parameter: 876104
substance units: 678703
reaction: 876078
species: 876076
type: SBMLModel
parameter: 876094
reaction: 876084
parameter: 876106
parameter: 876108
length unit: length
created:
  W3 CDTF: Thu May 10 18:54:38 BST 2012
area units: area
is: MODEL1203010002
parameter: 876102
occurs in: http://identifiers.org/taxonomy/4932
name: Ratushny2012_ASSURE_II
parameter: 876092
reaction: 876082
creator:
  ORG:
    orgname: Institute for Systems Biology (ISB) and Seattle BioMed
  n:
    given: Alexander
    family: Ratushny
volume units: 678655
parameter: 876098

876080
kinetic law: 982547
reactant: 982535
fast: false
reversible: false
type: Reaction

982559
stoichiometry: 1.0
species: 876076
type: SpeciesReference

876085
value: 0.1
type: LocalParameter

982535
stoichiometry: 1.0
species: 876074
type: SpeciesReference

982583
stoichiometry: 1.0
species: 876076
type: SpeciesReference

876074
is version of: GO:0003675
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
in compartment: 876072
type: Species

876098
constant: false
value: NaN
type: Parameter

876086
value: 0.1
type: LocalParameter

876108
constant: true
value: 0.1
type: Parameter

982511
stoichiometry: 1.0
species: 876074
type: SpeciesReference

876072
is version of: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment