BIOMD0000000419
parameter: 665333
parameter: 665340
volume units: 678655
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
reaction: 665320
rule: 665327
name: Ratushny2012_SPF_I
creator:
  ORG:
    orgname: Institute for Systems Biology (ISB) and Seattle BioMed
  n:
    given: Alexander
    family: Ratushny
time units: 678679
modified:
  W3 CDTF: Wed Jul 11 19:14:11 BST 2012
reaction: 665317
reaction: 665313
parameter: 665331
occurs in: http://identifiers.org/taxonomy/4932
notes: This model is from the article: Asymmetric positive feedback loops reliably control biological responses Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison Mol Syst Biol. 2012 Apr 24;8:577. 22531117 , Abstract: Positive feedback is a common mechanism enabling biological systems to respond to stimuli in a switch-like manner. Such systems are often characterized by the requisite formation of a heterodimer where only one of the pair is subject to feedback. This ASymmetric Self-UpREgulation (ASSURE) motif is central to many biological systems, including cholesterol homeostasis (LXRα/RXRα), adipocyte differentiation (PPARγ/RXRα), development and differentiation (RAR/RXR), myogenesis (MyoD/E12) and cellular antiviral defense (IRF3/IRF7). To understand why this motif is so prevalent, we examined its properties in an evolutionarily conserved transcriptional regulatory network in yeast (Oaf1p/Pip2p). We demonstrate that the asymmetry in positive feedback confers a competitive advantage and allows the system to robustly increase its responsiveness while precisely tuning the response to a consistent level in the presence of varying stimuli. This study reveals evolutionary advantages for the ASSURE motif, and mechanisms for control, that are relevant to pharmacologic intervention and synthetic biology applications. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, La…
parameter: 665330
parameter: 665342
is described by: http://identifiers.org/pubmed/22531117
parameter: 665334
is: MODEL1203010004
compartment: 665308
substance units: 678703
area units: area
reaction: 665315
reaction: 665318
reaction: 665314
length unit: length
species: 665310
parameter: 665337
is version of: GO:0006355
species: 665312
parameter: 665336
type: SBMLModel
parameter: 665329
rule: 665328
curated: true
created:
  W3 CDTF: Thu May 10 18:51:08 BST 2012
species: 665309
parameter: 665339

665342
constant: true
value: 1000.0
type: Parameter

665315
kinetic law: 831382
product: 831370
fast: false
reversible: false
type: Reaction

831321
stoichiometry: 1.0
species: 665309
type: SpeciesReference

831370
stoichiometry: 1.0
species: 665310
type: SpeciesReference

665313
kinetic law: 831333
product: 831321
fast: false
reversible: false
type: Reaction

665340
constant: true
value: 0.1
type: Parameter

665337
constant: true
value: 40.0
type: Parameter

831418
stoichiometry: 1.0
species: 665312
type: SpeciesReference

831442
stoichiometry: 1.0
species: 665312
type: SpeciesReference

665339
constant: true
value: 10.0
type: Parameter

665308
is version of: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

665331
constant: false
value: NaN
type: Parameter

665333
constant: false
value: NaN
type: Parameter

665318
kinetic law: 831430
product: 831418
fast: false
reversible: false
type: Reaction

665325
value: 0.1
type: LocalParameter

665329
constant: true
value: 1.0E-5
type: Parameter

665314
kinetic law: 831358
reactant: 831346
fast: false
reversible: false
type: Reaction

665312
is: SBO:0000011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
in compartment: 665308
type: Species

831346
stoichiometry: 1.0
species: 665309
type: SpeciesReference

665310
is version of: GO:0003675
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
in compartment: 665308
type: Species

665324
value: 0.1
type: LocalParameter

665309
is version of: GO:0003675
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10.0
in compartment: 665308
type: Species

665322
value: 0.1
type: LocalParameter

665320
kinetic law: 831454
reactant: 831442
fast: false
reversible: false
type: Reaction

831394
stoichiometry: 1.0
species: 665310
type: SpeciesReference

665330
constant: true
value: 0.001
type: Parameter

665336
constant: true
value: 0.1
type: Parameter

665317
kinetic law: 831406
reactant: 831394
fast: false
reversible: false
type: Reaction

665334
constant: true
value: 2.0
type: Parameter