815658
constant: true
value: 1.0
type: Parameter

815484
encodes: Q9FZ33
is: SBO:0000278
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815676
constant: true
value: 1.0
type: Parameter

691183
stoichiometry: 1.0
species: 815498
type: SpeciesReference

815668
constant: true
value: 100.0
type: Parameter

815648
constant: true
value: 0.1
type: Parameter

815550
kinetic law: 691063
modifier: 691051
modifier: 691039
product: 691027
is version of: GO:0016310
fast: false
reversible: false
type: Reaction

815638
constant: true
value: 1.0
type: Parameter

690557
stoichiometry: 1.0
species: 815461
type: SpeciesReference

815471
encodes: Q9SL42
is: SBO:0000278
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

690617
stoichiometry: 1.0
species: 815463
type: SpeciesReference

815618
constant: true
value: 1.0
type: Parameter

690955
stoichiometry: 1.0
species: 815490
type: SpeciesReference

815465
is version of: P49677
boundary condition: false
initial concentration: 0.0
type: Species
constant: false
in compartment: 815457
has only substance units: false
is version of: Q94JM3
initial amount: NaN
is: SBO:0000297

815496
has only substance units: false
type: Species
constant: false
in compartment: 815457
is version of: Q940D0
initial amount: NaN
is: SBO:0000252
boundary condition: false
is version of: C00562
initial concentration: 0.0

815628
constant: true
value: 0.5
type: Parameter

815608
constant: true
value: 100.0
type: Parameter

815688
constant: true
value: 1.0
type: Parameter

815656
constant: true
value: 0.1
type: Parameter

690702
stoichiometry: 1.0
species: 815467
type: SpeciesReference

815678
constant: true
value: 1.0
type: Parameter

690991
stoichiometry: 1.0
species: 815491
type: SpeciesReference

815636
constant: true
value: 100.0
type: Parameter

815483
is version of: Q9SL42
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815510
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815463
is version of: P49677
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815616
constant: true
value: 1.0
type: Parameter

815530
kinetic law: 690641
modifier: 690629
product: 690617
is version of: GO:0043241
fast: false
reversible: false
type: Reaction

815494
is version of: CHEBI:23530
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 815457
type: Species

690919
stoichiometry: 1.0
species: 815486
type: SpeciesReference

815686
constant: true
value: 1.0
type: Parameter

815488
is version of: Q570C0
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815560
product: 691291
kinetic law: 691351
modifier: 691315
reversible: false
fast: false
modifier: 691339
is version of: GO:0006412
modifier: 691303
type: Reaction
modifier: 691327

690787
stoichiometry: 1.0
species: 815471
type: SpeciesReference

815672
constant: true
value: 1.0
type: Parameter

815634
constant: true
value: 10.0
type: Parameter

815460
is: SBO:0000296
has part: CHEBI:22676
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
has part: Q570C0
in compartment: 815457
initial concentration: 0.0

815644
constant: true
value: 0.1
type: Parameter

815604
constant: true
value: 1.0
type: Parameter

815489
is version of: Q94JM3
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815548
kinetic law: 691015
modifier: 691003
product: 690991
is version of: GO:0006412
fast: false
reversible: false
type: Reaction

815522
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815532
kinetic law: 690690
modifier: 690677
modifier: 690665
product: 690653
is version of: GO:0006461
fast: false
reversible: false
type: Reaction

815461
has part: P49677
has part: Q570C0
boundary condition: false
is: SBO:0000296
initial amount: NaN
type: Species
has part: CHEBI:22676
constant: false
in compartment: 815457
initial concentration: 0.0
has only substance units: false

815486
is version of: Q9FZ33
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815684
constant: true
value: 1.0
type: Parameter

815674
constant: true
value: 0.1
type: Parameter

691027
stoichiometry: 1.0
species: 815492
type: SpeciesReference

815632
constant: true
value: 10.0
type: Parameter

815508
type: Species
boundary condition: false
initial concentration: 0.0
has only substance units: false
is: SBO:0000296
has part: Q9C5U0
in compartment: 815457
constant: false
initial amount: NaN
has part: CHEBI:23530

690871
stoichiometry: 1.0
species: 815484
type: SpeciesReference

815646
constant: true
value: 0.01
type: Parameter

BIOMD0000000416
species: 815502
parameter: 815620
reaction: 815546
reaction: 815532
area units: area
species: 815514
species: 815471
parameter: 815686
species: 815491
species: 815484
parameter: 815674
rule: 815590
rule: 815588
reaction: 815554
species: 815522
parameter: 815692
type: SBMLModel
parameter: 815626
name: Muraro2011_Cytokinin-Auxin_CrossRegulation
rule: 815586
reaction: 815550
parameter: 815598
parameter: 815658
parameter: 815680
reaction: 815542
parameter: 815614
species: 815461
species: 815494
species: 815460
parameter: 815664
parameter: 815646
species: 815458
time units: 678679
parameter: 815602
compartment: 815457
parameter: 815634
parameter: 815652
reaction: 815536
length unit: length
species: 815510
occurs in: http://identifiers.org/taxonomy/3702
rule: 815576
parameter: 815640
reaction: 815524
rule: 815577
rule: 815582
volume units: 678655
rule: 815594
parameter: 815694
parameter: 815628
species: 815467
notes: This model is from the article: The influence of cytokinin-auxin cross-regulation on cell-fate determination in Arabidopsis thaliana root development Muraro D, Byrne H, King J, Voss U, Kieber J, Bennett M. J Theor Biol. 2011 Aug 21;283(1):152-67. PMID: 21640126 , Abstract: Root growth and development in Arabidopsis thaliana are sustained by a specialised zone termed the meristem, which contains a population of dividing and differentiating cells that are functionally analogous to a stem cell niche in animals. The hormones auxin and cytokinin control meristem size antagonistically. Local accumulation of auxin promotes cell division and the initiation of a lateral root primordium. By contrast, high cytokinin concentrations disrupt the regular pattern of divisions that characterises lateral root development, and promote differentiation. The way in which the hormones interact is controlled by a genetic regulatory network. In this paper, we propose a deterministic mathematical model to describe this network and present model simulations that reproduce the experimentally observed effects of cytokinin on the expression of auxin regulated genes. We show how auxin response genes and auxin efflux transporters may be affected by the presence of cytokinin. We also analyse and compare the responses of the hormones auxin and cytokinin to changes in their supply with the responses obtained by genetic mutations of SHY2, which encodes a protein that plays a key role in balancing cytokinin and auxin regulation of meristem size. We show that although shy2 mutations can qualitatively reproduce the effect of varying auxin and cytokinin supply on their response genes, some elements of the network respond differently to changes in hormonal supply and to genetic mutations, implying a different, general response of the network. We conclude that an analysis based on the ratio between these two hormones may be misleading and that a mathematical model can serve as a useful tool for stimulate fu…
parameter: 815682
parameter: 815616
species: 815496
parameter: 815648
species: 815504
species: 815459
parameter: 815670
parameter: 815604
parameter: 815618
parameter: 815636
parameter: 815622
species: 815516
reaction: 815538
reaction: 815534
reaction: 815526
parameter: 815642
parameter: 815610
species: 815486
curated: true
parameter: 815688
parameter: 815660
species: 815492
parameter: 815630
substance units: 678703
parameter: 815676
is: MODEL1203080000
reaction: 815523
reaction: 815556

691255
stoichiometry: 1.0
species: 815500
type: SpeciesReference

690485
stoichiometry: 1.0
species: 815460
type: SpeciesReference

815606
constant: true
value: 1.0
type: Parameter

815534
kinetic law: 690727
modifier: 690715
product: 690702
is version of: GO:0006412
fast: false
reversible: false
type: Reaction

815520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815498
type: Species
boundary condition: false
constant: false
is version of: C00562
initial concentration: 0.0
is version of: Q9ZWJ9
has only substance units: false
initial amount: NaN
in compartment: 815457
is: SBO:0000252

690739
stoichiometry: 1.0
species: 815469
type: SpeciesReference

815558
kinetic law: 691279
modifier: 691267
product: 691255
is version of: GO:0009299
fast: false
reversible: false
type: Reaction

815526
fast: false
type: Reaction
product: 690485
kinetic law: 690545
modifier: 690521
modifier: 690509
is version of: GO:0006461
modifier: 690497
reversible: false
modifier: 690533

815458
encodes: P49677
constant: false
has only substance units: false
initial amount: NaN
is version of: CHEBI:33699
in compartment: 815457
is: SBO:0000278
type: Species
boundary condition: false
initial concentration: 0.0

815536
kinetic law: 690775
modifier: 690763
modifier: 690751
product: 690739
is version of: GO:0009851
fast: false
reversible: false
type: Reaction

815544
kinetic law: 690943
modifier: 690931
product: 690919
is version of: GO:0006412
fast: false
reversible: false
type: Reaction

815516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815506
boundary condition: false
constant: false
in compartment: 815457
initial amount: NaN
type: Species
initial concentration: 0.0
has only substance units: false
has part: Q9C5U0
has part: CHEBI:23530
is: SBO:0000296

815682
constant: true
value: 1.0
type: Parameter

815620
constant: true
value: 0.1
type: Parameter

815630
constant: true
value: 0.1
type: Parameter

815610
constant: true
value: 2.0
type: Parameter

815459
is version of: P49677
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815640
constant: true
value: 1.0
type: Parameter

815660
constant: true
value: 2.0
type: Parameter

815600
constant: true
value: 0.02
type: Parameter

815650
constant: true
value: 0.1
type: Parameter

815598
constant: true
value: 0.1
type: Parameter

815524
modifier: 690461
reversible: false
product: 690401
modifier: 690425
type: Reaction
modifier: 690413
is version of: GO:0006412
kinetic law: 690473
modifier: 690449
fast: false
modifier: 690437

815556
modifier: 691207
type: Reaction
modifier: 691195
modifier: 691219
reversible: false
fast: false
is version of: GO:0016310
modifier: 691231
product: 691183
kinetic law: 691243

815546
kinetic law: 690979
modifier: 690967
product: 690955
is version of: GO:0009299
fast: false
reversible: false
type: Reaction

815538
kinetic law: 690823
modifier: 690811
modifier: 690799
product: 690787
is version of: GO:0009299
fast: false
reversible: false
type: Reaction

815690
constant: true
value: 1.0
type: Parameter

815518
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

690341
stoichiometry: 1.0
species: 815458
type: SpeciesReference

W3 CDTF: Fri May 18 11:41:58 BST 2012

815670
constant: true
value: 1.0
type: Parameter

690835
stoichiometry: 1.0
species: 815483
type: SpeciesReference

691075
stoichiometry: 1.0
species: 815494
type: SpeciesReference

815680
constant: true
value: 1.0
type: Parameter

815504
is version of: Q940D0
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815523
product: 690341
is version of: GO:0009299
fast: false
reversible: false
kinetic law: 690388
type: Reaction
modifier: 690364
modifier: 690376
modifier: 690352

815622
constant: true
value: 1.0
type: Parameter

815642
constant: true
value: 1.0
type: Parameter

815662
constant: true
value: 1.0
type: Parameter

815602
constant: true
value: 1.0
type: Parameter

815596
constant: true
value: 0.01
type: Parameter

691291
stoichiometry: 1.0
species: 815502
type: SpeciesReference

815692
constant: true
value: 0.1
type: Parameter

815554
type: Reaction
modifier: 691135
fast: false
reversible: false
modifier: 691159
modifier: 691147
kinetic law: 691171
product: 691123
is version of: GO:0016310

815540
kinetic law: 690859
modifier: 690847
product: 690835
is version of: GO:0006412
fast: false
reversible: false
type: Reaction

690401
stoichiometry: 1.0
species: 815459
type: SpeciesReference

815502
is version of: Q940D0
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815512
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815469
is version of: CHEBI:22676
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 815457
type: Species

815624
constant: true
value: 10.0
type: Parameter

815491
is version of: O82503
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815614
constant: true
value: 1.0
type: Parameter

815492
initial concentration: 1.0
type: Species
is version of: C00562
in compartment: 815457
is version of: Q9C5U0
boundary condition: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

815654
constant: true
value: 0.1
type: Parameter

815664
constant: true
value: 1.0
type: Parameter

815694
constant: true
value: 0.1
type: Parameter

815552
kinetic law: 691111
modifier: 691099
modifier: 691087
product: 691075
is version of: GO:0009691
fast: false
reversible: false
type: Reaction

815490
encodes: O82503
is: SBO:0000278
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815528
product: 690557
fast: false
modifier: 690593
kinetic law: 690605
type: Reaction
modifier: 690569
modifier: 690581
reversible: false
is version of: GO:0006461

815542
kinetic law: 690907
modifier: 690895
modifier: 690883
product: 690871
is version of: GO:0009299
fast: false
reversible: false
type: Reaction

815500
encodes: Q940D0
is: SBO:0000278
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

691123
stoichiometry: 1.0
species: 815496
type: SpeciesReference

815514
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

W3 CDTF: Tue Apr 10 18:36:57 BST 2012

815467
is version of: Q94JM3
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 815457
type: Species

815626
constant: true
value: 1.0
type: Parameter

815457
is version of: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

690653
stoichiometry: 1.0
species: 815465
type: SpeciesReference

815612
constant: true
value: 100.0
type: Parameter

815666
constant: true
value: 2.0
type: Parameter

815652
constant: true
value: 0.1
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

ORG:
  orgname: University of Nottingham
n:
  given: Daniele
  family: Muraro