metaid_0000041
notes: Binary dissociation constant ATP
constant: true
units: metaid_0000004
value: 900.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_7a8602e1_d51e_40d4_a83f_362fb561f96d
persistant: true
initial value: true
type: Trigger

http://identifiers.org/biomodels.db/BIOMD0000000408#_50b96057_7d58_4ab0_bf52_adc112b684a4
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/BIOMD0000000408#_04d59d83_bac9_47ab_9bc9_bcaf0ccc9e48
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000059
boundary condition: false
is: http://identifiers.org/pubchem.substance/3594
initial amount: NaN
type: Species
name: Cri
in compartment: metaid_0000054
initial concentration: 9789.0
is: C00300
is: CHEBI:16919
constant: false
is: B00084
substance units: metaid_0000003
has only substance units: false

metaid_0000063
initial concentration: 5601.0
is: CHEBI:15422
substance units: metaid_0000003
initial amount: NaN
type: Species
is: B01125
name: ATP
constant: false
is: http://identifiers.org/pubchem.substance/3304
in compartment: metaid_0000055
has only substance units: false
is: C00002
boundary condition: false

metaid_0000078
notes: Diffusion of inorganic phosphate across the mitochondrial outer membrane
constant: false
units: metaid_0000005
value: 0.0
type: Parameter

metaid_0000031
notes: Maximum velocity Mi-CK (PCr production) without any inhibition by IAA of IA
constant: true
units: metaid_0000005
value: 882.0756
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_6524cd84_ee3a_43e7_9706_2d3284f6c6dc
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000408#_1d646160_d7c3_4ab5_95c5_e813386c7b90
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

metaid_0000011
notes: fraction of time in the cardiac cycle where diastole takes place
constant: false
value: 0.6666
type: Parameter

metaid_0000058
substance units: metaid_0000003
is: http://identifiers.org/pubchem.substance/3304
type: Species
is: CHEBI:15422
name: ATPi
has only substance units: false
is: B01125
is: C00002
in compartment: metaid_0000054
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 5626.0

metaid_0000021
notes: Factor of inhibition of creatine kinase reaction when the heart is exposed to iodoacetic acid (IAA)
constant: true
value: 1.0
name: ck_factor_iaa
type: Parameter

metaid_0000083
is: GO:0006817
fast: false
reversible: true
type: Reaction

metaid_0000090
use values from trigger time: true
name: nonpulsatile_step
type: Event

http://identifiers.org/biomodels.db/BIOMD0000000408#c151a466_8c90_40cb_8323_e65ff565fa7f
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000042
notes: Ternary dissociation constant Cr
constant: true
units: metaid_0000004
value: 15500.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_9b5a571d_fb2e_40f9_935a_0726aa340fb6
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000408#_0f9df7f1_bfd3_4f9f_9d79_4eec58b45c8d
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

http://identifiers.org/biomodels.db/BIOMD0000000408#bca11c3c_bffe_4d62_b4f6_e4040fee9191
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000064
initial concentration: 9789.0
is: CHEBI:16919
has only substance units: false
initial amount: NaN
type: Species
substance units: metaid_0000003
name: Cr
in compartment: metaid_0000055
is: C00300
is: B00084
boundary condition: false
is: http://identifiers.org/pubchem.substance/3594
constant: false

metaid_0000050
notes: Permeability surface product for the permeability of the outer mitochondrial membrane to inorganic phosphate
constant: true
units: metaid_0000092
value: 194.0
name: PSmomPi
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_1fd2395b_8975_4d08_9576_ee0b417f87d0
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

metaid_0000032
notes: Maximum velocity MM-CK (ATP production) without inhibition by IA or IAA
constant: true
units: metaid_0000005
value: 11441.78
type: Parameter

BIOMD0000000408
parameter: metaid_0000076
type: SBMLModel
reaction: metaid_0000081
parameter: metaid_0000015
species: metaid_0000057
reaction: metaid_0000082
parameter: metaid_0000052
units def: metaid_0000091
rule: metaid_0000093
rule: metaid_0000105
rule: metaid_0000109
rule: metaid_0000110
rule: metaid_0000100
rule: metaid_0000096
reaction: metaid_0000087
parameter: metaid_0000035
species: metaid_0000062
volume units: volume
parameter: metaid_0000043
parameter: metaid_0000072
event: metaid_0000090
event: metaid_0000089
notes: This model is from the article: Analyzing the functional properties of the creatine kinase system with multiscale 'sloppy' modeling. Hettling H, van Beek JH PLoS Comput Biol. 2011 Aug;7(8):e1002130. PMEDID , Abstract: In this study the function of the two isoforms of creatine kinase (CK; EC 2.7.3.2) in myocardium is investigated. The 'phosphocreatine shuttle' hypothesis states that mitochondrial and cytosolic CK plays a pivotal role in the transport of high-energy phosphate (HEP) groups from mitochondria to myofibrils in contracting muscle. Temporal buffering of changes in ATP and ADP is another potential role of CK. With a mathematical model, we analyzed energy transport and damping of high peaks of ATP hydrolysis during the cardiac cycle. The analysis was based on multiscale data measured at the level of isolated enzymes, isolated mitochondria and on dynamic response times of oxidative phosphorylation measured at the whole heart level. Using 'sloppy modeling' ensemble simulations, we derived confidence intervals for predictions of the contributions by phosphocreatine (PCr) and ATP to the transfer of HEP from mitochondria to sites of ATP hydrolysis. Our calculations indicate that only 15±8% (mean±SD) of transcytosolic energy transport is carried by PCr, contradicting the PCr shuttle hypothesis. We also predicted temporal buffering capabilities of the CK isoforms protecting against high peaks of ATP hydrolysis (3750 µM*s(-1)) in myofibrils. CK inhibition by 98% in silico leads to an increase in amplitude of mitochondrial ATP synthesis pulsation from 215±23 to 566±31 µM*s(-1), while amplitudes of oscillations in cytosolic ADP concentration double from 77±11 to 146±1 µM. Our findings indicate that CK acts as a large bandwidth high-capacity temporal energy buffer maintaining cellular ATP homeostasis and reducing oscillations in mitochondrial metabolism. However, the contribution of CK to the transport of high-energy phosphate groups appears limited. Mitochondrial CK ac…
parameter: metaid_0000034
parameter: metaid_0000044
parameter: metaid_0000040
parameter: metaid_0000006
parameter: metaid_0000011
parameter: metaid_0000037
parameter: metaid_0000014
rule: metaid_0000099
time units: time
parameter: metaid_0000016
parameter: metaid_0000026
parameter: metaid_0000010
parameter: metaid_0000020
reaction: metaid_0000083
parameter: metaid_0000067
parameter: metaid_0000077
parameter: metaid_0000017
species: metaid_0000066
compartment: metaid_0000055
parameter: metaid_0000073
parameter: metaid_0000068
rule: metaid_0000104
rule: metaid_0000108
units def: metaid_0000092
is: MODEL1201250000
parameter: metaid_0000053
is described by: http://identifiers.org/pubmed/21912519
species: metaid_0000064
species: metaid_0000061
parameter: metaid_0000045
units def: metaid_0000003
parameter: metaid_0000036
parameter: metaid_0000046
is derived from: BIOMD0000000041
rule: metaid_0000095
parameter: metaid_0000048
parameter: metaid_0000008
units def: metaid_0000004
parameter: metaid_0000025
rule: metaid_0000102
rule: metaid_0000098
rule: metaid_0000112
parameter: metaid_0000050
parameter: metaid_0000021
parameter: metaid_0000031
parameter: metaid_0000007
parameter: metaid_0000018
parameter: metaid_0000012
parameter: metaid_0000022
reaction: metaid_0000084
parameter: metaid_0000069
parameter: metaid_0000019
species: metaid_0000065
parameter: metaid_0000027
parameter: metaid_0000075
species: metaid_0000060
compartment: metaid_0000054

http://identifiers.org/biomodels.db/BIOMD0000000408#_8930cf1d_72bb_4e32_a7b8_68c7714562cf
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000077
notes: Diffusion of creatine across the mitochondrial outer membrane
constant: false
units: metaid_0000005
value: 0.0
type: Parameter

metaid_0000012
notes: fraction of time in the cardiac cycle where systole takes place and where the energy demand is still increasing (before the energy consumption peak)
constant: true
value: 0.1666666666
type: Parameter

metaid_0000070
notes: Time constant of ATP synthesis time course in response to a step in ATP demand
constant: false
units: second
value: 0.0
type: Parameter

metaid_0000084
is: GO:0015881
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000408#_031a2b0f_087e_4996_a3c8_dc47c1623175
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000057
name: ADPi
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.substance/3310
substance units: metaid_0000003
is: B01130
in compartment: metaid_0000054
boundary condition: false
initial concentration: 39.0
is: C00008
type: Species
is: CHEBI:16761
has only substance units: false

http://identifiers.org/biomodels.db/BIOMD0000000408#c3707642_d581_4c07_922b_5fb9134637ff
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000022
notes: Factor of inhibition of creatine kinase reaction when the heart is exposed to iodoacetamide (IA)
constant: true
value: 0.0286
name: ck_factor_ia
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#f84d5cdb_a52a_412a_ae06_1df948eb981f
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000051
notes: Permeability surface product for the permeability of the outer mitochondrial membrane to creatine
constant: true
units: metaid_0000092
value: 155.0
name: PSmomCr
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_3de747a4_0443_4e17_9b72_8e11ef7b93a0
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000038
notes: Ternary dissociation constant PCr
constant: true
units: metaid_0000004
value: 500.0
type: Parameter

metaid_0000061
is: CHEBI:17287
is: B00422
in compartment: metaid_0000055
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.substance/5359
substance units: metaid_0000003
initial amount: NaN
name: PCr
is: C02305
type: Species
initial concentration: 5710.0

metaid_0000043
notes: Binary dissociation constant ADP
constant: true
units: metaid_0000004
value: 222.4
type: Parameter

metaid_0000071
notes: Normalized ATP production time course
constant: false
value: 0.0
type: Parameter

metaid_0000081
reversible: true
type: Reaction
is: http://identifiers.org/ec-code/2.7.3.2
is: GO:0004111
fast: false

metaid_0000023
notes: Internal parameter for tmito calculation. Value is zero in base condition, otherwise one
constant: false
value: 0.0
name: tmito_factor
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_719a3711_3053_4050_9b9a_4d3006668b28
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000018
notes: Average ATP hydrolysis at base condition
constant: true
units: metaid_0000005
value: 486.5
name: Jhyd_basis
type: Parameter

metaid_0000092
name: per_second
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/BIOMD0000000408#_7dc8a498_341b_45b1_ab03_34693cc2ecf2
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000044
notes: Ternary dissociation constant PCr
constant: true
units: metaid_0000004
value: 1670.0
type: Parameter

metaid_0000039
notes: Binary dissociation constant Cr
constant: true
units: metaid_0000004
value: 28800.0
type: Parameter

metaid_0000052
notes: Permeability surface product for the permeability of the outer mitochondrial membrane to phosphocreatine
constant: true
units: metaid_0000092
value: 155.0
name: PSmomPCr
type: Parameter

metaid_0000089
use values from trigger time: true
name: pulsatile_basis
type: Event

metaid_0000079
is: GO:0006754
is: GO:0006757
reversible: true
fast: false
type: Reaction

metaid_0000062
has only substance units: false
constant: false
initial concentration: 64.0
is: B01130
is: C00008
substance units: metaid_0000003
type: Species
initial amount: NaN
in compartment: metaid_0000055
name: ADP
is: http://identifiers.org/pubchem.substance/3310
boundary condition: false
is: CHEBI:16761

metaid_0000010
notes: heart rate at test condition
constant: true
units: metaid_0000091
value: 220.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#fe08e1e5_f740_482b_9274_6e6498c30784
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000408#d2c7f5a8_f281_4570_81a2_e9d8b6e6e91e
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000072
notes: ATP synthesis time course
constant: false
units: metaid_0000005
value: 0.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_1581af73_c8fd_4389_af48_a0b67b824a55
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000024
notes: Permeability surface product for the permeability of the outer mitochondrial membrane to ATP and ADP
constant: true
units: metaid_0000092
value: 13.29477
name: PSmomATP
type: Parameter

metaid_0000082
is: http://identifiers.org/ec-code/3.6.4.1
fast: false
reversible: true
type: Reaction

metaid_0000019
notes: Last time in simulation where the 'pulsatile' event took place
constant: false
units: second
value: 0.0
type: Parameter

metaid_0000069
notes: Denominator for ATP synthsis rearction term, see eq. A25 in van Beek, Am J Physiol Cell Physiol. 2007 Sep;293(3):C815-29
constant: false
value: 0.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_77bce95f_7e64_4001_907a_00cbbfbfb125
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000091
name: per_minute
type: SBMLUnitsDef

metaid_0000007
notes: phase of pulsatile ATP hydrolysis
constant: false
value: 0.0
type: Parameter

metaid_0000035
notes: Binary dissociation constant ATP
constant: true
units: metaid_0000004
value: 750.0
type: Parameter

metaid_0000025
notes: Equilibrium constant for Mi-CK and MM-CK
constant: true
value: 152.0
name: K_CK_eq
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_8ecb7781_e26d_467c_a607_0a079f54816d
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000045
notes: Binary dissociation constant Cr
constant: true
units: metaid_0000004
value: 34900.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_7c03f587_189a_4737_b02c_3933654bc5ff
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000408#_279e9954_f739_458e_8f32_1ac4215ebf95
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000068
notes: Diffusion of ATP across the mitochondrial outer membrane
constant: false
units: metaid_0000005
value: 1.0
type: Parameter

metaid_0000073
notes: Fraction of high-energy phosphate transported across the mitochondrial outer membrane via phosphocreatine
constant: false
value: 1.0
type: Parameter

metaid_0000016
notes: Time point in simulation, where the heart rate is increased (base condition to test condition)
constant: true
units: second
value: 40.0
name: time_Jhyd_step
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#c79989e0_abd7_4c1a_9679_27ba6462a2d0
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000054
is: GO:0005758
constant: true
size: 0.0625
spatial dimensions: 3.0
name: IMS
type: Compartment

metaid_0000026
notes: Maximum velocity MM-CK (PCr production)
constant: false
units: metaid_0000005
value: 46303.5434543713
type: Parameter

metaid_0000087
is: GO:0051503
fast: false
is: GO:0006810
is: GO:0015867
reversible: true
type: Reaction

metaid_0000036
notes: Ternary dissociation constant Cr
constant: true
units: metaid_0000004
value: 5200.0
type: Parameter

metaid_0000006
notes: stepsize for integration
constant: true
units: second
value: 0.001
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_53fe1ffb_c5c5_439f_ac31_749ad3a73e65
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000080
is: http://identifiers.org/ec-code/2.7.3.2
type: Reaction
is: GO:0004111
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000408#dd34b090_dc16_45ae_ba68_ee3cac2cb6fc
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000046
notes: Binary dissociation constant PCr
constant: true
units: metaid_0000004
value: 4730.0
type: Parameter

metaid_0000060
is: B00422
is: http://identifiers.org/pubchem.substance/5359
is: C02305
type: Species
is: CHEBI:17287
in compartment: metaid_0000054
has only substance units: false
substance units: metaid_0000003
initial concentration: 5711.0
constant: false
name: PCri
initial amount: NaN
boundary condition: false

metaid_0000067
notes: Diffusion of phosphocreatine across the mitochondrial outer membrane
constant: false
units: metaid_0000005
value: 1.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_3f44f76e_d7e3_40f5_8134_7ef070092b31
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000017
notes: Average rate of ATP hydrolysis at test condition
constant: false
units: metaid_0000005
value: 627.6
name: Jhyd_test
type: Parameter

metaid_0000074
notes: Flux of mitochondrial creatine kinase reaction
constant: false
units: metaid_0000005
value: 0.0
name: j_ck_mi
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_8b171e3b_1fe1_4445_b182_debd542f4ef9
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000027
notes: Maximum velocity Mi-CK (ATP production)
constant: false
units: metaid_0000005
value: 3520.34110227692
type: Parameter

metaid_0000053
notes: 1 if simulation with pulsatile ATP hydrolysis function is desired, otherwise 0
constant: false
value: 1.0
name: pulsatility
type: Parameter

metaid_0000088
is: S000028563
use values from trigger time: true
name: pulsatile_test
type: Event

metaid_0000037
notes: Binary dissociation constant ADP
constant: true
units: metaid_0000004
value: 204.8
type: Parameter

metaid_0000009
notes: heart rate at base condition (before heart rate gets altered)
constant: true
units: metaid_0000091
value: 135.0
type: Parameter

metaid_0000033
notes: Maximum velocity Mi-CK (PCr production)
constant: false
units: metaid_0000005
value: 882.0756
type: Parameter

metaid_0000047
notes: Maximum ATP synthesis velocity
constant: true
units: metaid_0000005
value: 1503.74
name: Vmaxsyn
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_0960d228_a683_4920_bccc_18361cabb527
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000013
notes: fraction of time in the cardiac cycle where systole takes place and where the energy demand is decreasing (after the energy consumption peak)
constant: true
value: 0.1666666666
type: Parameter

metaid_0000075
notes: Flux of cytosolic creatine kinase reaction
constant: false
units: metaid_0000005
value: 0.0
name: j_ck_mm
type: Parameter

metaid_0000048
notes: Apparent Km mitochondria for ADP
constant: true
units: metaid_0000004
value: 25.0
name: Kadp
type: Parameter

metaid_0000066
has only substance units: false
type: Species
boundary condition: false
substance units: metaid_0000003
in compartment: metaid_0000055
initial concentration: 912.0
constant: false
initial amount: NaN
is: CHEBI:24838
name: P_i

metaid_0000056
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000040
notes: Binary dissociation constant PCr
constant: true
units: metaid_0000004
value: 1600.0
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#fe2a2b6a_8d59_4201_ac8a_8acd0c02ecc4
persistant: true
initial value: true
type: Trigger

metaid_0000085
is: GO:0015866
is: GO:0051503
fast: false
reversible: true
type: Reaction

metaid_0000008
notes: Current heart rate
constant: false
units: metaid_0000091
value: 135.0
type: Parameter

metaid_0000034
notes: Maximum velocity MM-CK (ATP production)
constant: false
units: metaid_0000005
value: 11441.78
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_753f24b7_d97c_4a4b_bbe1_c83bdc0f908e
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000408#_16cbcf78_3dba_48f4_82a8_5c7a48841819
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000014
notes: Amplitude of ATP hydrolysis time course at base condition (lower heart rate)
constant: false
units: metaid_0000005
value: 2918.41631673665
type: Parameter

metaid_0000065
has only substance units: false
constant: false
is: CHEBI:24838
initial concentration: 910.0
substance units: metaid_0000003
type: Species
in compartment: metaid_0000054
name: P_ii
initial amount: NaN
boundary condition: false

metaid_0000015
notes: Amplitude of ATP hydrolysis time course at test condition (elevated heart rate)
constant: false
units: metaid_0000005
value: 3764.84703059388
type: Parameter

metaid_0000076
notes: Diffusion of ADP across the mitochondrial outer membrane
constant: false
units: metaid_0000005
value: 0.0
type: Parameter

metaid_0000020
notes: Time course of ATP hydrolysis
constant: false
units: metaid_0000005
value: 486.5
name: Jhyd
type: Parameter

http://identifiers.org/biomodels.db/BIOMD0000000408#_8841bf41_e241_477a_859b_8ac304f42ef2
persistant: true
initial value: true
type: Trigger

metaid_0000049
notes: Apparent Km mitochondria for inorganic phosphate
constant: true
units: metaid_0000004
value: 800.0
name: Kpi
type: Parameter

metaid_0000055
is: GO:0005829
constant: true
size: 0.75
spatial dimensions: 3.0
name: CYT
type: Compartment

metaid_0000086
is: GO:0015881
is: GO:0006810
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000408#_36cdaed1_5eef_4f5c_8db6_2542a7a718c7
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

orgname: EMBL-EBI

given: Vijayalakshmi
family: Chelliah

W3 CDTF: Fri Jun 07 18:09:02 BST 2013

orgname: VU University Amsterdam

n:
  given: Hannes
  family: Hettling

W3 CDTF: Thu Jan 26 13:59:48 GMT 2012