289522
is: SBO:0000363
units: 450004
value: 0.3
name: Caspase-8 activation by TNFR Complex2~FLIP~Procaspase-8 ka
type: LocalParameter

40
is version of: P55212
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: 0.064
boundary condition: false
has only substance units: true
name: pCasp6
constant: false
substance units: 449980
in compartment: 289177

3
is: SBO:0000297
in compartment: 289178
has only substance units: true
name: TNF:TNFR_E
substance units: 449980
boundary condition: false
type: Species
is version of: P01375
initial concentration: NaN
initial amount: 0.0
is version of: P19438
constant: false

450708
stoichiometry: 1.0
species: 9
type: SpeciesReference

289512
is: SBO:0000009
units: 450088
value: 0.3125
name: FLIP recruitment to TNFR Complex2 ka
type: LocalParameter

30
is: SBO:0000252
substance units: 449980
in compartment: 289179
initial concentration: NaN
type: Species
boundary condition: false
constant: false
has only substance units: true
is version of: P25963
name: IkBa_N
initial amount: 0.0013839

289474
is: SBO:0000009
units: 450052
value: 2.0256E-5
name: RIP turnover ka
type: LocalParameter

289360
kinetic law: 450403
reactant: 450391
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex1 degradation
type: Reaction

449992
exponent: 1.0
scale: -18
multipler: 1.0
kind: MOLE
type: SBMLUnit

289388
kinetic law: 451268
product: 451256
reactant: 451244
reactant: 451232
is: SBO:0000526
fast: false
reversible: false
name: Procaspase-8 recruitment to TNFR Complex2~FLIP
type: Reaction

21
substance units: 449980
type: Species
boundary condition: false
name: TNFRC2:FLIP:pCasp8:RIP:TRAF2
is version of: Q15628
is version of: Q13158
is version of: O15519
constant: false
is version of: Q12933
in compartment: 289177
is: SBO:0000297
has only substance units: true
is version of: P19438
initial amount: 0.0
is version of: P01375
is version of: Q13546
is version of: Q14790
initial concentration: NaN

450695
stoichiometry: 1.0
species: 7
type: SpeciesReference

11
is version of: P01375
is version of: Q13546
initial concentration: NaN
boundary condition: false
is version of: Q15628
name: TNFRCint1
substance units: 449980
constant: false
type: Species
is version of: Q12933
is: SBO:0000297
has only substance units: true
in compartment: 289177
is version of: P19438
initial amount: 0.0

289560
is: SBO:0000337
units: 450088
value: 1.25
name: IkappaBalpha NF-kappaB association ka
type: LocalParameter

289350
kinetic law: 450210
product: 450198
is: SBO:0000393
fast: false
reversible: false
name: TNFR production
type: Reaction

450271
stoichiometry: 1.0
species: 6
type: SpeciesReference

2
initial concentration: NaN
is: SBO:0000252
substance units: 449980
initial amount: 0.2688
has only substance units: true
boundary condition: false
type: Species
name: TNF_E
in compartment: 289178
constant: false
is version of: P01375

289179
is version of: GO:0005634
is: SBO:0000290
constant: true
units: 450028
size: 1.056
spatial dimensions: 3.0
type: Compartment

289378
kinetic law: 450892
product: 450879
reactant: 450866
reactant: 450853
is: SBO:0000395
fast: false
reversible: false
name: Receptor internalisation step3
type: Reaction

41
initial concentration: NaN
is version of: Q14790
substance units: 449980
is: SBO:0000252
type: Species
boundary condition: false
name: Casp8
has only substance units: true
in compartment: 289177
constant: false
initial amount: 0.0

289521
is: SBO:0000009
units: 450088
value: 0.3125
name: Procaspase-8 recruitment to TNFR Complex2~FLIP ka
type: LocalParameter

451001
stoichiometry: 1.0
species: 16
type: SpeciesReference

4
is version of: P19438
substance units: 449980
type: Species
initial amount: 2.8E-4
is: SBO:0000252
has only substance units: true
constant: false
boundary condition: false
in compartment: 289177
name: TNFR
initial concentration: NaN

450367
stoichiometry: 1.0
species: 9
type: SpeciesReference

20
is version of: Q14790
is version of: P19438
substance units: 449980
is: SBO:0000297
initial amount: 0.0
has only substance units: true
in compartment: 289177
is version of: Q15628
name: TNFRC2:FLIP:pCasp8
is version of: P01375
type: Species
is version of: O15519
initial concentration: NaN
is version of: Q13158
constant: false
boundary condition: false

289475
is: SBO:0000009
units: 450004
value: 1.0E-4
name: RIP turnover kd
type: LocalParameter

31
type: Species
is: SBO:0000297
constant: false
is version of: P19838
initial amount: 9.00189E-5
name: IkBa:NFkB_N
initial concentration: NaN
is version of: P25963
boundary condition: false
has only substance units: true
substance units: 449980
in compartment: 289179

289390
kinetic law: 451317
product: 451305
product: 451293
reactant: 451280
is: SBO:0000180
fast: false
reversible: false
name: Caspase-8 activation by TNFR Complex2~FLIP~Procaspase-8
type: Reaction

453049
stoichiometry: 1.0
species: 5
type: SpeciesReference

289387
kinetic law: 451220
product: 451208
reactant: 451195
reactant: 451183
is: SBO:0000526
fast: false
reversible: false
name: FLIP recruitment to TNFR Complex2~Procaspase-8
type: Reaction

451280
stoichiometry: 1.0
species: 20
type: SpeciesReference

452641
stoichiometry: 1.0
species: 43
type: SpeciesReference

451039
stoichiometry: 1.0
species: 14
type: SpeciesReference

451365
stoichiometry: 1.0
species: 21
type: SpeciesReference

453133
stoichiometry: 1.0
species: 47
type: SpeciesReference

10
type: Species
is version of: Q12933
is: SBO:0000297
initial concentration: NaN
boundary condition: false
initial amount: 0.0
is version of: Q13546
has only substance units: true
in compartment: 289177
is version of: P19438
is version of: P01375
is version of: Q15628
name: TNFRC1
substance units: 449980
constant: false

289501
is: SBO:0000337
units: 450004
value: 6.60377E-5
name: TNF~TNFR binding and release kd
type: LocalParameter

289461
kinetic law: 453001
modifier: 452989
reactant: 452977
is: SBO:0000179
fast: false
reversible: false
name: XIAP degradation due to Caspase-3
type: Reaction

451401
stoichiometry: 1.0
species: 23
type: SpeciesReference

450682
stoichiometry: 1.0
species: 5
type: SpeciesReference

289524
is: SBO:0000009
units: 450124
value: 0.00976562
name: RIP~TRAF2 recruitment at TNFR Complex2~FLIP~Procaspase-8 ka
type: LocalParameter

289348
kinetic law: 450185
product: 450173
reactant: 450161
is: SBO:0000185
fast: false
reversible: false
name: TNFR transport into membrane
type: Reaction

42
substance units: 449980
is: SBO:0000252
initial concentration: NaN
type: Species
is version of: P42574
name: Casp3
boundary condition: false
constant: false
has only substance units: true
initial amount: 0.0
in compartment: 289177

289177
is version of: GO:0005737
is: SBO:0000290
constant: true
units: 450028
size: 3.2
spatial dimensions: 3.0
type: Compartment

451014
stoichiometry: 1.0
species: 18
type: SpeciesReference

289409
kinetic law: 451713
reactant: 451701
is: SBO:0000179
fast: false
reversible: false
name: nuclear IkappaBalpha~NF-kappaB complex degradation
type: Reaction

289510
is: SBO:0000009
units: 450004
value: 0.1135
name: Receptor internalisation step4 ka
type: LocalParameter

289488
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex1 degradation ka
type: LocalParameter

451821
stoichiometry: 1.0
species: 22
type: SpeciesReference

452797
stoichiometry: 1.0
species: 42
type: SpeciesReference

289362
kinetic law: 450427
reactant: 450415
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2 degradation
type: Reaction

23
type: Species
constant: false
boundary condition: false
substance units: 449980
is: SBO:0000252
initial amount: 0.0
in compartment: 289177
is version of: O15111
name: IKKa
has only substance units: true
initial concentration: NaN

289472
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR degradation ka
type: LocalParameter

452305
stoichiometry: 1.0
species: 32
type: SpeciesReference

289504
is: SBO:0000337
units: 450124
value: 0.0976562
name: TNFR Complex1 building ka
type: LocalParameter

289462
kinetic law: 453037
product: 453025
reactant: 453013
is: SBO:0000180
fast: false
reversible: false
name: XIAP~Caspase-3 complex breakup
type: Reaction

289376
fast: false
kinetic law: 450840
product: 450801
product: 450827
type: Reaction
is: SBO:0000395
reversible: false
name: Receptor internalisation step2
product: 450814
reactant: 450788

450657
stoichiometry: 1.0
species: 9
type: SpeciesReference

289375
kinetic law: 450775
product: 450762
reactant: 450748
is: SBO:0000395
fast: false
reversible: false
name: Receptor internalisation step1
type: Reaction

289489
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2 degradation ka
type: LocalParameter

22
initial concentration: NaN
constant: false
is: SBO:0000252
name: IKK
boundary condition: false
in compartment: 289177
is version of: O15111
has only substance units: true
substance units: 449980
type: Species
initial amount: 0.64

289503
is: SBO:0000337
units: 450088
value: 0.00427827
name: TNF~TNFR~TRADD building ka
type: LocalParameter

43
in compartment: 289177
name: Casp6
initial concentration: NaN
boundary condition: false
is version of: P55212
type: Species
is: SBO:0000252
substance units: 449980
has only substance units: true
initial amount: 0.0
constant: false

289178
is version of: GO:0005576
is: SBO:0000290
constant: true
units: 450028
size: 1344.0
spatial dimensions: 3.0
type: Compartment

1
has only substance units: true
boundary condition: false
initial amount: 0.005
substance units: 449980
constant: false
is: SBO:0000252
type: Species
is version of: P19438
name: TNFR_E
initial concentration: NaN
in compartment: 289178

451353
stoichiometry: 1.0
species: 20
type: SpeciesReference

452713
stoichiometry: 1.0
species: 44
type: SpeciesReference

450645
stoichiometry: 1.0
species: 6
type: SpeciesReference

289610
is: SBO:0000337
units: 450004
value: 0.001
name: XIAP~Caspase-3 complex formation kd
type: LocalParameter

452929
stoichiometry: 1.0
species: 37
type: SpeciesReference

289450
kinetic law: 452725
reactant: 452713
is: SBO:0000179
fast: false
reversible: false
name: BAR~Caspase-8 complex degradation
type: Reaction

450721
stoichiometry: 1.0
species: 10
type: SpeciesReference

451329
stoichiometry: 1.0
species: 5
type: SpeciesReference

289384
kinetic law: 451123
product: 451111
reactant: 451099
reactant: 451087
is: SBO:0000526
fast: false
reversible: false
name: Procaspase-8 recruitment to TNFR Complex2~Procaspase-8
type: Reaction

289374
reactant: 450695
kinetic law: 450735
reactant: 450708
reversible: false
product: 450721
name: TNFR Complex1 building
fast: false
type: Reaction
reactant: 450682
is: SBO:0000526

452785
stoichiometry: 1.0
species: 39
type: SpeciesReference

289516
is: SBO:0000009
units: 450088
value: 0.03125
name: Procaspase-8 recruitment to TNFR Complex2~Procaspase-8 ka
type: LocalParameter

289354
kinetic law: 450283
product: 450271
is: SBO:0000357
fast: false
reversible: true
name: TRADD turnover
type: Reaction

15
is version of: O15519
in compartment: 289177
substance units: 449980
boundary condition: false
initial concentration: NaN
constant: false
has only substance units: true
type: Species
initial amount: 0.0320472
is: SBO:0000252
name: FLIP

25
boundary condition: false
type: Species
initial concentration: NaN
is version of: P19838
constant: false
has only substance units: true
is: SBO:0000252
name: NFkB
substance units: 449980
in compartment: 289177
initial amount: 1.15365E-4

451087
stoichiometry: 1.0
species: 17
type: SpeciesReference

289364
kinetic law: 450475
reactant: 450463
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP~FLIP degradation
type: Reaction

289394
kinetic law: 451449
product: 451437
is: SBO:0000357
fast: false
reversible: true
name: IKK turnover
type: Reaction

450076
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

451389
stoichiometry: 1.0
species: 22
type: SpeciesReference

451966
stoichiometry: 1.0
species: 25
type: SpeciesReference

289515
is: SBO:0000009
units: 450088
value: 0.03125
name: Procaspase-8 recruitment to TNFR Complex2 ka
type: LocalParameter

289383
kinetic law: 451075
product: 451063
reactant: 451051
reactant: 451039
is: SBO:0000526
fast: false
reversible: false
name: Procaspase-8 recruitment to TNFR Complex2
type: Reaction

452665
stoichiometry: 1.0
species: 45
type: SpeciesReference

452881
stoichiometry: 1.0
species: 38
type: SpeciesReference

289601
is: SBO:0000009
units: 450004
value: 5.78704E-6
name: PARP turnover ka
type: LocalParameter

289525
is: SBO:0000363
units: 450088
value: 0.03125
name: IKK activation by TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2 ka
type: LocalParameter

450343
stoichiometry: 1.0
species: 3
type: SpeciesReference

14
constant: false
is version of: P01375
boundary condition: false
type: Species
is version of: P19438
initial concentration: NaN
is version of: Q13158
has only substance units: true
is version of: Q15628
substance units: 449980
name: TNFRC2
initial amount: 0.0
is: SBO:0000297
in compartment: 289177

289471
is: SBO:0000009
units: 450052
value: 2.8E-7
name: TNFR production ka
type: LocalParameter

24
has only substance units: true
is version of: P21580
initial concentration: NaN
initial amount: 0.104434
boundary condition: false
name: A20
type: Species
substance units: 449980
in compartment: 289177
constant: false
is: SBO:0000252

289363
kinetic law: 450451
reactant: 450439
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP degradation
type: Reaction

289612
is: SBO:0000356
units: 450088
value: 1.875
name: XIAP degradation due to Caspase-3 ka
type: LocalParameter

289386
kinetic law: 451171
product: 451159
product: 451147
reactant: 451135
is: SBO:0000180
fast: false
reversible: false
name: Caspase-8 activation by TNFR Complex2
type: Reaction

289391
product: 451365
name: RIP~TRAF2 recruitment at TNFR Complex2~FLIP~Procaspase-8
reversible: false
reactant: 451329
type: Reaction
is: SBO:0000526
fast: false
kinetic law: 451377
reactant: 451353
reactant: 451341

289528
is: SBO:0000009
units: 450004
value: 1.0E-4
name: IKK turnover kd
type: LocalParameter

289366
kinetic law: 450499
reactant: 450487
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~Procaspase-8 degradation
type: Reaction

450633
stoichiometry: 1.0
species: 3
type: SpeciesReference

289372
kinetic law: 450669
product: 450657
reactant: 450645
reactant: 450633
is: SBO:0000526
fast: false
reversible: false
name: TNF~TNFR~TRADD building
type: Reaction

451099
stoichiometry: 1.0
species: 38
type: SpeciesReference

289500
is: SBO:0000337
units: 450088
value: 0.00953471
name: TNF~TNFR binding and release ka
type: LocalParameter

289352
kinetic law: 450259
product: 450246
is: SBO:0000357
fast: false
reversible: true
name: RIP turnover
type: Reaction

13
is version of: P19438
is version of: Q13158
has only substance units: true
in compartment: 289177
name: TNFRCint3
is version of: P01375
type: Species
constant: false
substance units: 449980
initial concentration: NaN
is version of: Q15628
boundary condition: false
initial amount: 0.0
is: SBO:0000297

450016
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

27
initial amount: 0.0151032
boundary condition: false
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false
name: IkBa:NFkB
is version of: P19838
has only substance units: true
in compartment: 289177
is version of: P25963
substance units: 449980

452893
stoichiometry: 1.0
species: 41
type: SpeciesReference

289613
is: SBO:0000282
units: 450004
value: 5.0E-5
name: XIAP~Caspase-3 complex breakup ka
type: LocalParameter

289392
kinetic law: 451425
modifier: 451413
product: 451401
reactant: 451389
is: SBO:0000170
fast: false
reversible: false
name: IKK activation by TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2
type: Reaction

289527
is: SBO:0000009
units: 450052
value: 6.4E-5
name: IKK turnover ka
type: LocalParameter

289513
is: SBO:0000009
units: 450088
value: 0.3125
name: FLIP recruitment to TNFR Complex2~FLIP ka
type: LocalParameter

450064
exponent: 1.0
scale: -18
multipler: 1.0
kind: MOLE
type: SBMLUnit

451978
stoichiometry: 1.0
species: 26
type: SpeciesReference

289371
kinetic law: 450620
product: 450608
reactant: 450596
reactant: 450584
is: SBO:0000526
fast: false
reversible: true
name: TNF~TNFR binding and release
type: Reaction

451437
stoichiometry: 1.0
species: 22
type: SpeciesReference

453169
stoichiometry: 1.0
species: 36
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

450608
stoichiometry: 1.0
species: 3
type: SpeciesReference

12
is version of: P01375
initial amount: 0.0
is: SBO:0000297
initial concentration: NaN
boundary condition: false
type: Species
is version of: P19438
name: TNFRCint2
constant: false
substance units: 449980
has only substance units: true
in compartment: 289177
is version of: Q15628

289351
kinetic law: 450234
reactant: 450222
is: SBO:0000179
fast: false
reversible: false
name: TNFR degradation
type: Reaction

452617
stoichiometry: 1.0
species: 42
type: SpeciesReference

452377
stoichiometry: 1.0
species: 34
type: SpeciesReference

26
type: Species
constant: false
name: IkBa
boundary condition: false
is: SBO:0000252
initial concentration: NaN
initial amount: 0.00101518
is version of: P25963
substance units: 449980
has only substance units: true
in compartment: 289177

452026
stoichiometry: 1.0
species: 25
type: SpeciesReference

38
constant: false
initial concentration: NaN
is: SBO:0000252
in compartment: 289177
is version of: Q14790
boundary condition: false
has only substance units: true
initial amount: 3.2
substance units: 449980
type: Species
name: pCasp8

451135
stoichiometry: 1.0
species: 19
type: SpeciesReference

452689
stoichiometry: 1.0
species: 36
type: SpeciesReference

450965
stoichiometry: 1.0
species: 16
type: SpeciesReference

289370
kinetic law: 450572
reactant: 450560
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2 degradation
type: Reaction

289380
kinetic law: 450977
product: 450965
reactant: 450953
reactant: 450941
is: SBO:0000526
fast: false
reversible: false
name: FLIP recruitment to TNFR Complex2
type: Reaction

451749
stoichiometry: 1.0
species: 32
type: SpeciesReference

289398
kinetic law: 451521
product: 451509
is: SBO:0000357
fast: false
reversible: true
name: XIAP turnover
type: Reaction

39
is: SBO:0000252
substance units: 449980
initial concentration: NaN
initial amount: 0.8
in compartment: 289177
type: Species
constant: false
is version of: P42574
name: pCasp3
boundary condition: false
has only substance units: true

450112
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

289529
is: SBO:0000009
units: 450052
value: 1.6E-6
name: NF-kappaB turnover ka
type: LocalParameter

450439
stoichiometry: 1.0
species: 16
type: SpeciesReference

451905
stoichiometry: 1.0
species: 10
type: SpeciesReference

452086
stoichiometry: 1.0
species: 29
type: SpeciesReference

289594
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: Caspase-6 degradation ka
type: LocalParameter

451232
stoichiometry: 1.0
species: 16
type: SpeciesReference

450391
stoichiometry: 1.0
species: 10
type: SpeciesReference

451147
stoichiometry: 1.0
species: 14
type: SpeciesReference

36
type: Species
initial amount: 0.28789
constant: false
initial concentration: NaN
in compartment: 289177
boundary condition: false
is: SBO:0000252
has only substance units: true
substance units: 449980
name: BAR
is version of: Q9NZS9

450762
stoichiometry: 1.0
species: 11
type: SpeciesReference

451917
stoichiometry: 1.0
species: 7
type: SpeciesReference

452038
stoichiometry: 1.0
species: 28
type: SpeciesReference

289595
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: XIAP~Caspase-3 complex degradation ka
type: LocalParameter

451533
stoichiometry: 1.0
species: 24
type: SpeciesReference

9
is: SBO:0000297
is version of: Q15628
has only substance units: true
boundary condition: false
is version of: P01375
initial concentration: NaN
constant: false
substance units: 449980
is version of: P19438
in compartment: 289177
name: TNF:TNFR:TRADD
type: Species
initial amount: 0.0

451208
stoichiometry: 1.0
species: 20
type: SpeciesReference

289395
kinetic law: 451473
product: 451461
is: SBO:0000357
fast: false
reversible: true
name: NF-kappaB turnover
type: Reaction

289382
kinetic law: 451027
product: 451014
reactant: 451001
reactant: 450989
is: SBO:0000526
fast: false
reversible: false
name: FLIP recruitment to TNFR Complex2~FLIP
type: Reaction

37
name: XIAP
initial amount: 7.83371
is: SBO:0000252
is version of: P98170
substance units: 449980
initial concentration: NaN
in compartment: 289177
type: Species
boundary condition: false
has only substance units: true
constant: false

450222
stoichiometry: 1.0
species: 1
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451869
stoichiometry: 1.0
species: 23
type: SpeciesReference

289396
kinetic law: 451497
product: 451485
is: SBO:0000357
fast: false
reversible: true
name: FLIP turnover
type: Reaction

451881
stoichiometry: 1.0
species: 22
type: SpeciesReference

451293
stoichiometry: 1.0
species: 14
type: SpeciesReference

450198
stoichiometry: 1.0
species: 4
type: SpeciesReference

450941
stoichiometry: 1.0
species: 14
type: SpeciesReference

451341
stoichiometry: 1.0
species: 7
type: SpeciesReference

44
is version of: Q14790
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constant: false
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boundary condition: false
is version of: Q9NZS9
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initial concentration: NaN
type: Species
substance units: 449980
name: BAR:Casp8
in compartment: 289177

34
substance units: 449980
is: SBO:0000278
initial amount: 2.19646E-4
name: XIAP_mRNA
in compartment: 289179
boundary condition: false
is version of: ENST00000371199
has only substance units: true
type: Species
initial concentration: NaN
constant: false

289583
is: SBO:0000009
units: 450004
value: 6.17284E-5
name: Procaspase-8 turnover kd
type: LocalParameter

7
name: TRAF2
in compartment: 289177
is version of: Q12933
constant: false
substance units: 449980
initial amount: 0.33056
has only substance units: true
boundary condition: false
is: SBO:0000252
type: Species
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451159
stoichiometry: 1.0
species: 41
type: SpeciesReference

450788
stoichiometry: 1.0
species: 11
type: SpeciesReference

452341
stoichiometry: 1.0
species: 24
type: SpeciesReference

289570
is: SBO:0000337
units: 450088
value: 1.4348
name: IkappaBalpha binding NF-kappaB in nucleus ka
type: LocalParameter

451629
stoichiometry: 1.0
species: 33
type: SpeciesReference

45
substance units: 449980
initial amount: 0.0
constant: false
is version of: P42574
boundary condition: false
initial concentration: NaN
has only substance units: true
is: SBO:0000297
name: XIAP:Casp3
in compartment: 289177
is version of: P98170
type: Species

451833
stoichiometry: 1.0
species: 23
type: SpeciesReference

450748
stoichiometry: 1.0
species: 10
type: SpeciesReference

451256
stoichiometry: 1.0
species: 20
type: SpeciesReference

453193
stoichiometry: 1.0
species: 44
type: SpeciesReference

35
is: SBO:0000278
name: FLIP_mRNA
initial concentration: NaN
initial amount: 1.39056E-4
in compartment: 289179
is version of: ENST00000309955
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constant: false
substance units: 449980
boundary condition: false
has only substance units: true

450295
stoichiometry: 1.0
species: 7
type: SpeciesReference

289620
is: SBO:0000337
units: 450004
value: 0.001
name: BAR~Caspase-8 complex formation kd
type: LocalParameter

8
has only substance units: true
boundary condition: false
constant: false
is version of: Q13158
substance units: 449980
initial concentration: NaN
initial amount: 0.30944
is: SBO:0000252
in compartment: 289177
type: Species
name: FADD

450415
stoichiometry: 1.0
species: 14
type: SpeciesReference

450136
exponent: -2.0
scale: -18
multipler: 1.0
kind: MOLE
type: SBMLUnit

46
in compartment: 289177
substance units: 449980
is: SBO:0000252
initial amount: 1.66667
name: PARP
is version of: P09874
boundary condition: false
type: Species
has only substance units: true
initial concentration: NaN
constant: false

289399
kinetic law: 451545
product: 451533
is: SBO:0000357
fast: false
reversible: true
name: A20 turnover
type: Reaction

450953
stoichiometry: 1.0
species: 15
type: SpeciesReference

452737
stoichiometry: 1.0
species: 46
type: SpeciesReference

451557
stoichiometry: 1.0
species: 23
type: SpeciesReference

32
constant: false
is version of: ENST00000237289
name: A20_mRNA
in compartment: 289179
is: SBO:0000278
boundary condition: false
has only substance units: true
initial concentration: NaN
type: Species
substance units: 449980
initial amount: 5.56657E-5

289581
is: SBO:0000009
units: 450004
value: 0.00687273
name: FLIP translation ka
type: LocalParameter

453121
stoichiometry: 1.0
species: 46
type: SpeciesReference

5
initial amount: 0.20256
has only substance units: true
constant: false
boundary condition: false
in compartment: 289177
is version of: Q13546
type: Species
is: SBO:0000252
name: RIP
substance units: 449980
initial concentration: NaN

289591
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: Caspase-8 degradation ka
type: LocalParameter

453181
stoichiometry: 1.0
species: 41
type: SpeciesReference

289572
is: SBO:0000009
units: 450004
value: 0.0151515
name: IkappaBalpha_NF-kappaB N-C export ka
type: LocalParameter

47
initial amount: 0.0
boundary condition: false
has only substance units: true
type: Species
constant: false
is version of: P09874
initial concentration: NaN
name: cPARP
is: SBO:0000252
in compartment: 289177
substance units: 449980

450827
stoichiometry: 1.0
species: 12
type: SpeciesReference

451244
stoichiometry: 1.0
species: 38
type: SpeciesReference

289582
is: SBO:0000009
units: 450052
value: 1.97531E-4
name: Procaspase-8 turnover ka
type: LocalParameter

33
initial concentration: NaN
in compartment: 289179
is: SBO:0000278
is version of: ENST00000216797
initial amount: 5.31517E-5
type: Species
substance units: 449980
constant: false
boundary condition: false
has only substance units: true
name: IkBa_mRNA

452074
stoichiometry: 1.0
species: 25
type: SpeciesReference

450148
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

289592
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: Caspase-3 degradation ka
type: LocalParameter

6
name: TRADD
is version of: Q15628
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: true
boundary condition: false
substance units: 449980
initial amount: 0.29344
in compartment: 289177
constant: false

452977
stoichiometry: 1.0
species: 37
type: SpeciesReference

289588
is: SBO:0000009
units: 450052
value: 3.95062E-6
name: Procaspase-6 turnover ka
type: LocalParameter

450173
stoichiometry: 1.0
species: 1
type: SpeciesReference

451195
stoichiometry: 1.0
species: 17
type: SpeciesReference

450246
stoichiometry: 1.0
species: 5
type: SpeciesReference

450100
exponent: -1.0
scale: -18
multipler: 1.0
kind: MOLE
type: SBMLUnit

289449
kinetic law: 452701
product: 452689
is: SBO:0000357
fast: false
reversible: true
name: BAR turnover
type: Reaction

452485
stoichiometry: 1.0
species: 15
type: SpeciesReference

452146
stoichiometry: 1.0
species: 26
type: SpeciesReference

451677
stoichiometry: 1.0
species: 30
type: SpeciesReference

450596
stoichiometry: 1.0
species: 2
type: SpeciesReference

451051
stoichiometry: 1.0
species: 38
type: SpeciesReference

452245
stoichiometry: 1.0
species: 31
type: SpeciesReference

289587
is: SBO:0000009
units: 450004
value: 6.17284E-5
name: Procaspase-3 turnover kd
type: LocalParameter

289534
is: SBO:0000009
units: 450052
value: 7.72256E-4
name: XIAP turnover ka
type: LocalParameter

289421
reactant: 452014
type: Reaction
name: release and degradation of bound IkappaBalpha
fast: false
reversible: false
kinetic law: 452062
modifier: 452050
product: 452038
is: SBO:0000179
product: 452026

289448
kinetic law: 452677
reactant: 452665
is: SBO:0000179
fast: false
reversible: false
name: XIAP~Caspase-3 complex degradation
type: Reaction

289573
is: SBO:0000009
units: 450004
value: 3.78788E-5
name: A20-mRNA transcription ka
type: LocalParameter

451773
stoichiometry: 1.0
species: 34
type: SpeciesReference

289548
is: SBO:0000356
units: 450004
value: 1.0E-4
name: nuclear IkappaBalpha~NF-kappaB complex degradation ka
type: LocalParameter

289435
kinetic law: 452437
modifier: 452425
product: 452413
is: SBO:0000184
fast: false
reversible: false
name: XIAP translation
type: Reaction

289576
is: SBO:0000009
units: 450004
value: 3.33333E-5
name: XIAP-mRNA transcription ka
type: LocalParameter

453085
stoichiometry: 1.0
species: 15
type: SpeciesReference

289618
is: SBO:0000356
units: 450088
value: 0.1875
name: PARP cleavage as Casp3 substrate ka
type: LocalParameter

451509
stoichiometry: 1.0
species: 37
type: SpeciesReference

BIOMD0000000407
species: 12
species: 2
species: 22
units def: 450088
reaction: 289392
units def: 450124
species: 39
species: 8
species: 28
reaction: 289355
species: 29
compartment: 289178
reaction: 289396
reaction: 289388
species: 43
species: 20
length unit: length
reaction: 289461
reaction: 289359
species: 27
species: 36
species: 46
species: 5
species: 30
is described by: http://identifiers.org/pubmed/22204418
reaction: 289379
reaction: 289452
species: 41
reaction: 289403
reaction: 289358
species: 24
reaction: 289450
reaction: 289409
type: SBMLModel
reaction: 289423
compartment: 289177
time units: time
reaction: 289407
species: 3
reaction: 289443
reaction: 289376
species: 42
reaction: 289367
units def: 450028
reaction: 289440
reaction: 289432
reaction: 289467
species: 11
reaction: 289362
compartment: 289179
reaction: 289411
species: 17
reaction: 289436
reaction: 289382
reaction: 289431
reaction: 289456
reaction: 289415
reaction: 289351
reaction: 289462
species: 35
reaction: 289386
reaction: 289400
reaction: 289435
occurs in: http://identifiers.org/taxonomy/9606
reaction: 289371
reaction: 289419
reaction: 289455
reaction: 289404
curated: true
species: 19
species: 32
species: 13
reaction: 289391
species: 23
reaction: 289439
reaction: 289350
reaction: 289375
reaction: 289459
reaction: 289370
reaction: 289395

289422
kinetic law: 452098
product: 452086
reactant: 452074
is: SBO:0000185
fast: false
reversible: false
name: NF-kappaB nuclear translocation
type: Reaction

452196
stoichiometry: 1.0
species: 30
type: SpeciesReference

451605
stoichiometry: 1.0
species: 29
type: SpeciesReference

289535
is: SBO:0000009
units: 450004
value: 1.0E-4
name: XIAP turnover kd
type: LocalParameter

289545
is: SBO:0000356
units: 450004
value: 0.00154022
name: IkappaBalpha degradation ka
type: LocalParameter

289432
kinetic law: 452365
modifier: 452353
product: 452341
is: SBO:0000184
fast: false
reversible: false
name: A20 translation
type: Reaction

289575
is: SBO:0000009
units: 450004
value: 0.0151515
name: A20 translation ka
type: LocalParameter

289619
is: SBO:0000337
units: 450088
value: 0.520833
name: BAR~Caspase-8 complex formation ka
type: LocalParameter

452569
stoichiometry: 1.0
species: 40
type: SpeciesReference

289585
is: SBO:0000009
units: 450052
value: 4.93827E-5
name: Procaspase-3 turnover ka
type: LocalParameter

289423
kinetic law: 452134
modifier: 452122
product: 452110
is: SBO:0000183
fast: false
reversible: false
name: IkappaBalpha-mRNA transcription
type: Reaction

289536
is: SBO:0000009
units: 450052
value: 9.6E-6
name: A20 turnover ka
type: LocalParameter

450814
stoichiometry: 1.0
species: 7
type: SpeciesReference

289546
is: SBO:0000356
units: 450004
value: 1.0E-4
name: free nuclear IkappaBalpha degradation ka
type: LocalParameter

451701
stoichiometry: 1.0
species: 31
type: SpeciesReference

289433
kinetic law: 452401
modifier: 452389
product: 452377
is: SBO:0000183
fast: false
reversible: false
name: XIAP-mRNA transcription
type: Reaction

452281
stoichiometry: 1.0
species: 27
type: SpeciesReference

289557
is: SBO:0000349
units: 450004
value: 0.1
name: IKK* inactivation ka
type: LocalParameter

W3 CDTF: Mon Jan 16 14:48:14 GMT 2012

289410
kinetic law: 451737
reactant: 451725
is: SBO:0000179
fast: false
reversible: false
name: P-IkappaBa degradation
type: Reaction

289578
is: SBO:0000009
units: 450004
value: 0.0506061
name: XIAP translation ka
type: LocalParameter

289616
is: SBO:0000356
units: 450088
value: 0.15625
name: FLIP degradation by Caspase-3 ka
type: LocalParameter

289598
is: SBO:0000009
units: 450004
value: 5.78704E-6
name: BAR turnover kd
type: LocalParameter

452953
stoichiometry: 1.0
species: 45
type: SpeciesReference

289537
is: SBO:0000009
units: 450004
value: 1.0E-4
name: A20 turnover kd
type: LocalParameter

289558
is: SBO:0000349
units: 450088
value: 0.00625
name: TNFR Complex1 inactivation by A20 ka
type: LocalParameter

289411
kinetic law: 451761
reactant: 451749
is: SBO:0000179
fast: false
reversible: false
name: A20-mRNA degradation
type: Reaction

452269
stoichiometry: 1.0
species: 31
type: SpeciesReference

450319
stoichiometry: 1.0
species: 8
type: SpeciesReference

289431
kinetic law: 452329
modifier: 452317
product: 452305
is: SBO:0000183
fast: false
reversible: false
name: A20-mRNA transcription
type: Reaction

289597
is: SBO:0000009
units: 450052
value: 1.66603E-6
name: BAR turnover ka
type: LocalParameter

289538
is: SBO:0000356
units: 450004
value: 1.0E-4
name: IKK* degradation ka
type: LocalParameter

452413
stoichiometry: 1.0
species: 37
type: SpeciesReference

452110
stoichiometry: 1.0
species: 33
type: SpeciesReference

289569
is: SBO:0000009
units: 450004
value: 0.00257576
name: IkappaBalpha nuclear translocation kd
type: LocalParameter

450161
stoichiometry: 1.0
species: 4
type: SpeciesReference

450879
stoichiometry: 1.0
species: 13
type: SpeciesReference

451183
stoichiometry: 1.0
species: 15
type: SpeciesReference

289491
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP degradation ka
type: LocalParameter

451461
stoichiometry: 1.0
species: 25
type: SpeciesReference

289549
is: SBO:0000356
units: 450004
value: 0.0115517
name: P-IkappaBa degradation ka
type: LocalParameter

452941
stoichiometry: 1.0
species: 42
type: SpeciesReference

289589
is: SBO:0000009
units: 450004
value: 6.17284E-5
name: Procaspase-6 turnover kd
type: LocalParameter

289579
is: SBO:0000009
units: 450004
value: 3.33333E-5
name: FLIP-mRNA transcription ka
type: LocalParameter

289615
is: SBO:0000261
units: 450088
value: 0.15625
name: negative feedback loop Caspase-3 on TNFR Complex1 ka
type: LocalParameter

451725
stoichiometry: 1.0
species: 28
type: SpeciesReference

289599
is: SBO:0000356
units: 450004
value: 5.78704E-5
name: BAR~Caspase-8 complex degradation ka
type: LocalParameter

451063
stoichiometry: 1.0
species: 17
type: SpeciesReference

451111
stoichiometry: 1.0
species: 19
type: SpeciesReference

453013
stoichiometry: 1.0
species: 45
type: SpeciesReference

289455
kinetic law: 452821
modifier: 452809
product: 452797
reactant: 452785
is: SBO:0000170
fast: false
reversible: false
name: Caspase-3 activation
type: Reaction

289483
is: SBO:0000009
units: 450004
value: 1.0E-4
name: FADD turnover kd
type: LocalParameter

450040
exponent: 1.0
scale: -12
multipler: 1.0
kind: LITRE
type: SBMLUnit

18
initial amount: 0.0
is version of: Q13158
is version of: O15519
is version of: P01375
boundary condition: false
substance units: 449980
is version of: Q15628
type: Species
initial concentration: NaN
is version of: P19438
constant: false
has only substance units: true
in compartment: 289177
name: TNFRC2:FLIP:FLIP
is: SBO:0000297

28
boundary condition: false
name: PIkBa
type: Species
has only substance units: true
initial amount: 0.0
constant: false
initial concentration: NaN
in compartment: 289177
is version of: P25963
substance units: 449980
is: SBO:0000252

289428
kinetic law: 452257
product: 452245
reactant: 452233
reactant: 452221
is: SBO:0000526
fast: false
reversible: false
name: IkappaBalpha binding NF-kappaB in nucleus
type: Reaction

289507
is: SBO:0000009
units: 450004
value: 0.001135
name: Receptor internalisation step2 ka
type: LocalParameter

289469
is: SBO:0000009
units: 450004
value: 0.001
name: TNFR transport into membrane ka
type: LocalParameter

289414
kinetic law: 451809
reactant: 451797
is: SBO:0000179
fast: false
reversible: false
name: FLIP-mRNA degradation
type: Reaction

289603
is: SBO:0000356
units: 450004
value: 5.78704E-6
name: CPARP degradation ka
type: LocalParameter

289400
kinetic law: 451569
reactant: 451557
is: SBO:0000179
fast: false
reversible: false
name: IKK* degradation
type: Reaction

289367
kinetic law: 450523
reactant: 450511
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~Procaspase-8~Procaspase-8 degradation
type: Reaction

450905
stoichiometry: 1.0
species: 13
type: SpeciesReference

289482
is: SBO:0000009
units: 450052
value: 3.0944E-5
name: FADD turnover ka
type: LocalParameter

19
initial concentration: NaN
is version of: P19438
has only substance units: true
in compartment: 289177
substance units: 449980
name: TNFRC2:pCasp8:pCasp8
is version of: Q15628
type: Species
constant: false
is version of: Q13158
is version of: Q14790
is: SBO:0000297
initial amount: 0.0
is version of: P01375
boundary condition: false

289492
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP~FLIP degradation ka
type: LocalParameter

29
constant: false
name: NFkB_N
boundary condition: false
initial concentration: NaN
is: SBO:0000252
substance units: 449980
initial amount: 6.91431E-4
has only substance units: true
type: Species
in compartment: 289179
is version of: P19838

289429
kinetic law: 452293
product: 452281
reactant: 452269
is: SBO:0000185
fast: false
reversible: false
name: IkappaBalpha_NF-kappaB N-C export
type: Reaction

450463
stoichiometry: 1.0
species: 18
type: SpeciesReference

452833
stoichiometry: 1.0
species: 40
type: SpeciesReference

289468
kinetic law: 453205
product: 453193
reactant: 453181
reactant: 453169
is: SBO:0000526
fast: false
reversible: true
name: BAR~Caspase-8 complex formation
type: Reaction

289440
kinetic law: 452557
product: 452545
is: SBO:0000357
fast: false
reversible: true
name: Procaspase-3 turnover
type: Reaction

289540
is: SBO:0000356
units: 450004
value: 1.0E-4
name: IkappaBalpha~NF-kappaB complex degradation ka
type: LocalParameter

452014
stoichiometry: 1.0
species: 27
type: SpeciesReference

289358
kinetic law: 450355
reactant: 450343
is: SBO:0000179
fast: false
reversible: false
name: TNF~TNFR degradation
type: Reaction

289415
kinetic law: 451857
modifier: 451845
product: 451833
reactant: 451821
is: SBO:0000170
fast: false
reversible: false
name: IKK activation by TNFR Complex1
type: Reaction

289568
is: SBO:0000009
units: 450004
value: 0.005
name: IkappaBalpha nuclear translocation ka
type: LocalParameter

289602
is: SBO:0000009
units: 450052
value: 9.64506E-6
name: PARP turnover kd
type: LocalParameter

289554
is: SBO:0000356
units: 450004
value: 1.65744E-4
name: FLIP-mRNA degradation ka
type: LocalParameter

289368
kinetic law: 450547
reactant: 450535
is: SBO:0000179
fast: false
reversible: false
name: TNFR Complex2~FLIP~Procaspase-8 degradation
type: Reaction

289518
is: SBO:0000363
units: 450004
value: 0.45
name: Caspase-8 activation by TNFR Complex2 ka
type: LocalParameter

289481
is: SBO:0000009
units: 450004
value: 1.0E-4
name: TRAF2 turnover kd
type: LocalParameter

289453
kinetic law: 452773
reactant: 452761
is: SBO:0000179
fast: false
reversible: false
name: CPARP degradation
type: Reaction

452521
stoichiometry: 1.0
species: 38
type: SpeciesReference

289443
kinetic law: 452605
reactant: 452593
is: SBO:0000179
fast: false
reversible: false
name: Caspase-8 degradation
type: Reaction

450560
stoichiometry: 1.0
species: 21
type: SpeciesReference

16
substance units: 449980
is version of: O15519
is version of: Q15628
is: SBO:0000297
has only substance units: true
initial amount: 0.0
is version of: P19438
type: Species
is version of: P01375
constant: false
initial concentration: NaN
in compartment: 289177
name: TNFRC2:FLIP
is version of: Q13158
boundary condition: false

289605
is: SBO:0000363
units: 450088
value: 0.015625
name: Caspase-3 activation ka
type: LocalParameter

289355
kinetic law: 450307
product: 450295
is: SBO:0000357
fast: false
reversible: true
name: TRAF2 turnover
type: Reaction

289565
is: SBO:0000009
units: 450004
value: 3.0303E-5
name: IkappaBalpha-mRNA transcription ka
type: LocalParameter

289519
is: SBO:0000009
units: 450088
value: 0.3125
name: FLIP recruitment to TNFR Complex2~Procaspase-8 ka
type: LocalParameter

289555
is: SBO:0000363
units: 450088
value: 93.75
name: IKK activation by TNFR Complex1 ka
type: LocalParameter

289402
kinetic law: 451593
reactant: 451581
is: SBO:0000179
fast: false
reversible: false
name: IkappaBalpha~NF-kappaB complex degradation
type: Reaction

451485
stoichiometry: 1.0
species: 15
type: SpeciesReference

452845
stoichiometry: 1.0
species: 43
type: SpeciesReference

289494
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~Procaspase-8 degradation ka
type: LocalParameter

289442
kinetic law: 452581
product: 452569
is: SBO:0000357
fast: false
reversible: true
name: Procaspase-6 turnover
type: Reaction

450917
stoichiometry: 1.0
species: 14
type: SpeciesReference

17
in compartment: 289177
initial amount: 0.0
type: Species
is version of: Q13158
constant: false
boundary condition: false
name: TNFRC2:pCasp8
is version of: Q14790
has only substance units: true
is version of: P19438
is version of: P01375
substance units: 449980
is version of: Q15628
is: SBO:0000297
initial concentration: NaN

450989
stoichiometry: 1.0
species: 15
type: SpeciesReference

289413
kinetic law: 451785
reactant: 451773
is: SBO:0000179
fast: false
reversible: false
name: XIAP-mRNA degradation
type: Reaction

451929
stoichiometry: 1.0
species: 9
type: SpeciesReference

289506
is: SBO:0000009
units: 450004
value: 0.001135
name: Receptor internalisation step1 ka
type: LocalParameter

289566
is: SBO:0000009
units: 450004
value: 0.0606061
name: IkappaBalpha translation ka
type: LocalParameter

289356
kinetic law: 450331
product: 450319
is: SBO:0000357
fast: false
reversible: true
name: FADD turnover
type: Reaction

450511
stoichiometry: 1.0
species: 19
type: SpeciesReference

289452
kinetic law: 452749
reactant: 452737
is: SBO:0000357
fast: false
reversible: true
name: PARP turnover
type: Reaction

289403
kinetic law: 451617
reactant: 451605
is: SBO:0000179
fast: false
reversible: false
name: nuclear NF-kappaB degradation
type: Reaction

451581
stoichiometry: 1.0
species: 27
type: SpeciesReference

289543
is: SBO:0000356
units: 450004
value: 3.94201E-4
name: IkappaBalpha-mRNA degradation ka
type: LocalParameter

289445
kinetic law: 452629
reactant: 452617
is: SBO:0000179
fast: false
reversible: false
name: Caspase-3 degradation
type: Reaction

451990
stoichiometry: 1.0
species: 27
type: SpeciesReference

289459
kinetic law: 452965
product: 452953
reactant: 452941
reactant: 452929
is: SBO:0000526
fast: false
reversible: true
name: XIAP~Caspase-3 complex formation
type: Reaction

451797
stoichiometry: 1.0
species: 35
type: SpeciesReference

289404
kinetic law: 451641
reactant: 451629
is: SBO:0000179
fast: false
reversible: false
name: IkappaBalpha-mRNA degradation
type: Reaction

289418
product: 451929
is: SBO:0000169
reactant: 451905
fast: false
reversible: false
product: 451917
kinetic law: 451953
name: TNFR Complex1 inactivation by A20
type: Reaction
modifier: 451941

451653
stoichiometry: 1.0
species: 26
type: SpeciesReference

452221
stoichiometry: 1.0
species: 29
type: SpeciesReference

289479
is: SBO:0000009
units: 450052
value: 3.3056E-5
name: TRAF2 turnover ka
type: LocalParameter

289563
is: SBO:0000009
units: 450004
value: 0.0125
name: NF-kappaB nuclear translocation ka
type: LocalParameter

289497
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP~Procaspase-8 degradation ka
type: LocalParameter

289465
kinetic law: 453109
modifier: 453097
reactant: 453085
is: SBO:0000179
fast: false
reversible: false
name: FLIP degradation by Caspase-3
type: Reaction

450853
stoichiometry: 2.0
species: 8
type: SpeciesReference

289496
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~Procaspase-8~Procaspase-8 degradation ka
type: LocalParameter

289439
kinetic law: 452533
product: 452521
is: SBO:0000357
fast: false
reversible: true
name: Procaspase-8 turnover
type: Reaction

452184
stoichiometry: 1.0
species: 26
type: SpeciesReference

289425
kinetic law: 452172
modifier: 452159
product: 452146
is: SBO:0000184
fast: false
reversible: false
name: IkappaBalpha translation
type: Reaction

450801
stoichiometry: 1.0
species: 5
type: SpeciesReference

289458
kinetic law: 452917
modifier: 452905
product: 452893
reactant: 452881
is: SBO:0000170
fast: false
reversible: false
name: Caspase-8 activation
type: Reaction

289530
is: SBO:0000009
units: 450004
value: 1.0E-4
name: NF-kappaB turnover kd
type: LocalParameter

289419
kinetic law: 452002
product: 451990
reactant: 451978
reactant: 451966
is: SBO:0000526
fast: false
reversible: false
name: IkappaBalpha NF-kappaB association
type: Reaction

289486
is: SBO:0000356
units: 450004
value: 0.02352
name: TNF:TNFR:TRADD degradation ka
type: LocalParameter

450487
stoichiometry: 1.0
species: 17
type: SpeciesReference

289464
kinetic law: 453073
modifier: 453061
reactant: 453049
is: SBO:0000169
fast: false
reversible: false
name: negative feedback loop Caspase-3 on TNFR Complex1
type: Reaction

289606
is: SBO:0000363
units: 450088
value: 0.009375
name: Caspase-6 activation ka
type: LocalParameter

289436
kinetic law: 452473
modifier: 452461
product: 452449
is: SBO:0000183
fast: false
reversible: false
name: FLIP-mRNA transcription
type: Reaction

289379
kinetic law: 450929
product: 450917
reactant: 450905
is: SBO:0000395
fast: false
reversible: false
name: Receptor internalisation step4
type: Reaction

289541
is: SBO:0000356
units: 450004
value: 1.0E-4
name: nuclear NF-kappaB degradation ka
type: LocalParameter

289531
is: SBO:0000009
units: 450052
value: 2.24902E-6
name: FLIP turnover ka
type: LocalParameter

289426
kinetic law: 452209
product: 452196
reactant: 452184
is: SBO:0000526
fast: false
reversible: true
name: IkappaBalpha nuclear translocation
type: Reaction

289485
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNF~TNFR degradation ka
type: LocalParameter

289551
is: SBO:0000356
units: 450004
value: 4.70498E-4
name: A20-mRNA degradation ka
type: LocalParameter

289477
is: SBO:0000009
units: 450004
value: 1.0E-4
name: TRADD turnover kd
type: LocalParameter

452545
stoichiometry: 1.0
species: 39
type: SpeciesReference

289467
kinetic law: 453157
modifier: 453145
product: 453133
reactant: 453121
is: SBO:0000178
fast: false
reversible: false
name: PARP cleavage as Casp3 substrate
type: Reaction

289509
is: SBO:0000009
units: 450124
value: 0.0118534
name: Receptor internalisation step3 ka
type: LocalParameter

289406
kinetic law: 451665
reactant: 451653
is: SBO:0000179
fast: false
reversible: false
name: IkappaBalpha degradation
type: Reaction

453025
stoichiometry: 1.0
species: 37
type: SpeciesReference

289359
kinetic law: 450379
reactant: 450367
is: SBO:0000179
fast: false
reversible: false
name: TNF:TNFR:TRADD degradation
type: Reaction

289609
is: SBO:0000337
units: 450088
value: 0.625
name: XIAP~Caspase-3 complex formation ka
type: LocalParameter

452233
stoichiometry: 1.0
species: 30
type: SpeciesReference

452449
stoichiometry: 1.0
species: 35
type: SpeciesReference

289499
is: SBO:0000356
units: 450004
value: 5.6E-5
name: TNFR Complex2~FLIP~Procaspase-8~RIP~TRAF2 degradation ka
type: LocalParameter

450584
stoichiometry: 1.0
species: 1
type: SpeciesReference

289562
is: SBO:0000356
units: 450088
value: 0.104167
name: release and degradation of bound IkappaBalpha ka
type: LocalParameter

289437
kinetic law: 452509
modifier: 452497
product: 452485
is: SBO:0000184
fast: false
reversible: false
name: FLIP translation
type: Reaction

289446
kinetic law: 452653
reactant: 452641
is: SBO:0000179
fast: false
reversible: false
name: Caspase-6 degradation
type: Reaction

450535
stoichiometry: 1.0
species: 20
type: SpeciesReference

289532
is: SBO:0000009
units: 450004
value: 1.0E-4
name: FLIP turnover kd
type: LocalParameter

289456
kinetic law: 452869
modifier: 452857
product: 452845
reactant: 452833
is: SBO:0000170
fast: false
reversible: false
name: Caspase-6 activation
type: Reaction

451305
stoichiometry: 1.0
species: 41
type: SpeciesReference

289552
is: SBO:0000356
units: 450004
value: 1.04931E-4
name: XIAP-mRNA degradation ka
type: LocalParameter

289476
is: SBO:0000009
units: 450052
value: 2.9344E-5
name: TRADD turnover ka
type: LocalParameter

289417
kinetic law: 451893
product: 451881
reactant: 451869
is: SBO:0000169
fast: false
reversible: false
name: IKK* inactivation
type: Reaction

450866
stoichiometry: 1.0
species: 12
type: SpeciesReference

452761
stoichiometry: 1.0
species: 47
type: SpeciesReference

289407
kinetic law: 451689
reactant: 451677
is: SBO:0000179
fast: false
reversible: false
name: free nuclear IkappaBalpha degradation
type: Reaction

452593
stoichiometry: 1.0
species: 41
type: SpeciesReference

289608
is: SBO:0000363
units: 450088
value: 0.0015625
name: Caspase-8 activation ka
type: LocalParameter

W3 CDTF: Thu Mar 08 11:11:11 GMT 2012

orgname: Otto-von-Guericke-Universität Magdeburg

given: Monica
family: Schliemann