181146
constant: true
value: 0.86
type: Parameter

180431
in compartment: 180039
type: Species
name: _Beta_-Catenin
boundary condition: false
constant: false
initial concentration: NaN
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
has only substance units: false
initial amount: 5.0
is version of: P35222

225762
stoichiometry: 1.0
species: 180451
type: SpeciesReference

181138
constant: true
value: 1.68
type: Parameter

181124
constant: true
value: 1.13
type: Parameter

226648
stoichiometry: 1.0
species: 180521
type: SpeciesReference

226893
stoichiometry: 1.0
species: 180674
type: SpeciesReference

181104
constant: true
value: 1.09
type: Parameter

226440
stoichiometry: 1.0
species: 180237
type: SpeciesReference

225609
stoichiometry: 1.0
species: 180104
type: SpeciesReference

180848
kinetic law: 226267
product: 226255
product: 226243
reactant: 226231
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true
type: Reaction

226770
stoichiometry: 1.0
species: 180491
type: SpeciesReference

181118
constant: true
value: 0.48
type: Parameter

180039
constant: true
size: 1.0
spatial dimensions: 3.0
name: Plasma Membrane
type: Compartment

180967
kinetic law: 226782
product: 226770
reactant: 226758
reactant: 226746
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

226869
stoichiometry: 1.0
species: 180511
type: SpeciesReference

180632
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05608 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)
type: Species

226131
stoichiometry: 1.0
species: 180653
type: SpeciesReference

180471
initial amount: 0.0
initial concentration: NaN
name: _Beta_-Catenin
is version of: P35222
type: Species
in compartment: 180055
constant: false
has only substance units: false
boundary condition: false
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432

226955
stoichiometry: 1.0
species: 180204
type: SpeciesReference

226092
stoichiometry: 1.0
species: 180341
type: SpeciesReference

180743
kinetic law: 225826
product: 225813
reactant: 225800
reactant: 225788
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180270
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05622 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 3.0
in compartment: 180039
name: Complex_br_(Ebi/Siah-1)
type: Species

226054
stoichiometry: 1.0
species: 180643
type: SpeciesReference

180643
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05607 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)
type: Species

181136
constant: true
value: 0.649
type: Parameter

226636
stoichiometry: 1.0
species: 180204
type: SpeciesReference

180137
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05626 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;LRP5/6#PROTEIN#Low density lipoprotein receptor related protein#P01431#Arrow#;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Frizzled/Wnt/_br_LRP5/6)
type: Species

181126
constant: true
value: 0.91
type: Parameter

180531
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05639 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 5.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1)
type: Species

180187
constant: false
has part: P67870
name: Casein Kinase 2
boundary condition: false
type: Species
has only substance units: false
notes: Long Name: Casein Kinase 2 Synonym: Casein Kinase II,Protein Kinase CK2 Accession: P01459
in compartment: 180039
initial amount: 3.0
initial concentration: NaN
has part: P68400

226079
stoichiometry: 1.0
species: 180643
type: SpeciesReference

225737
stoichiometry: 1.0
species: 180441
type: SpeciesReference

181106
constant: true
value: 0.51
type: Parameter

180684
kinetic law: 225571
product: 225558
reactant: 225545
fast: false
reversible: false
type: Reaction

226881
stoichiometry: 1.0
species: 180371
type: SpeciesReference

180730
kinetic law: 225775
product: 225762
reactant: 225749
reactant: 225737
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

181116
constant: true
value: 1.277
type: Parameter

181144
constant: true
value: 1.32
type: Parameter

180955
kinetic law: 226733
product: 226721
reactant: 226709
reactant: 226697
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180896
kinetic law: 226452
product: 226440
reactant: 226428
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true
type: Reaction

225878
stoichiometry: 1.0
species: 180411
type: SpeciesReference

180321
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05637 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 3.0
in compartment: 180039
name: Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)
type: Species

180371
boundary condition: false
name: CBP
has only substance units: false
initial amount: 2.0
initial concentration: NaN
notes: Long Name: CREB binding protein Synonym: CREB binding protein Accession: P01448
is version of: P45481
constant: false
in compartment: 180055
type: Species

181070
constant: true
value: 0.72
type: Parameter

180907
kinetic law: 226489
product: 226477
reactant: 226465
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true
type: Reaction

226943
stoichiometry: 1.0
species: 180204
type: SpeciesReference

180361
initial amount: 2.0
is version of: Q9V9W8
type: Species
notes: Long Name: Pygopus Synonym: Pygopus Accession: P01464
in compartment: 180055
name: Pygo
boundary condition: false
initial concentration: NaN
has only substance units: false
constant: false

226193
stoichiometry: 1.0
species: 180541
type: SpeciesReference

180220
constant: false
is version of: CHEBI:16761
initial concentration: NaN
boundary condition: false
notes: Long Name: ADP Synonym: Synonym not specified Accession: S01880
type: Species
in compartment: 180039
initial amount: 0.0
name: ADP
has only substance units: false

226004
stoichiometry: 1.0
species: 180632
type: SpeciesReference

180331
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05614 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 4.0
in compartment: 180039
name: Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli)
type: Species

226697
stoichiometry: 1.0
species: 180491
type: SpeciesReference

226304
stoichiometry: 1.0
species: 180562
type: SpeciesReference

181090
constant: true
value: 0.36
type: Parameter

225711
stoichiometry: 1.0
species: 180441
type: SpeciesReference

181068
constant: true
value: 1.29
type: Parameter

180884
kinetic law: 226415
product: 226403
reactant: 226390
reactant: 226378
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180824
kinetic law: 226168
product: 226156
product: 226144
reactant: 226131
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true
type: Reaction

181128
constant: true
value: 1.056
type: Parameter

180766
kinetic law: 225916
product: 225903
reactant: 225890
reactant: 225878
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

181100
constant: true
value: 0.183
type: Parameter

226280
stoichiometry: 1.0
species: 180582
type: SpeciesReference

226144
stoichiometry: 1.0
species: 180622
type: SpeciesReference

181058
constant: true
value: 1.7
type: Parameter

181142
constant: true
value: 0.87
type: Parameter

181114
constant: true
value: 0.45
type: Parameter

180501
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05619 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo)
type: Species

225647
stoichiometry: 1.0
species: 180104
type: SpeciesReference

180087
constant: false
is version of: P56704
name: Wnt
initial concentration: NaN
has only substance units: false
type: Species
notes: Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444
initial amount: 0.0
boundary condition: false
in compartment: 180038

226105
stoichiometry: 1.0
species: 180653
type: SpeciesReference

180287
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05612 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Siah-1/Ebi)
type: Species

226795
stoichiometry: 1.0
species: 180551
type: SpeciesReference

226206
stoichiometry: 1.0
species: 180572
type: SpeciesReference

180789
kinetic law: 226017
product: 226004
reactant: 225992
reactant: 225980
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

226721
stoichiometry: 1.0
species: 180501
type: SpeciesReference

226156
stoichiometry: 1.0
species: 180551
type: SpeciesReference

181040
constant: true
value: 0.784
type: Parameter

225890
stoichiometry: 1.0
species: 180471
type: SpeciesReference

180120
initial amount: 3.0
initial concentration: NaN
has only substance units: false
notes: Long Name: Frizzled Synonym: Synonym not specified Accession: P01428
boundary condition: false
type: Species
name: Frizzled
constant: false
in compartment: 180039
is version of: P18537

181092
constant: true
value: 1.16
type: Parameter

181082
constant: true
value: 0.2
type: Parameter

226979
stoichiometry: 1.0
species: 180220
type: SpeciesReference

181001
kinetic law: 226905
product: 226893
reactant: 226881
reactant: 226869
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

226292
stoichiometry: 1.0
species: 180351
type: SpeciesReference

180979
kinetic law: 226819
product: 226807
reactant: 226795
notes: mass action rate law for first order irreversible reactions, continuous scheme
fast: false
reversible: false
type: Reaction

180582
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05635 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A)
type: Species

181041
constant: true
value: 0.82
type: Parameter

181056
constant: true
value: 0.8
type: Parameter

180104
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05624 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Wnt/Frizzled)
type: Species

180204
in compartment: 180039
notes: Long Name: ATP Synonym: Synonym not specified Accession: S01878
name: ATP
boundary condition: false
type: Species
initial concentration: NaN
initial amount: 1.0
has only substance units: false
is version of: CHEBI:15422
constant: false

226918
stoichiometry: 1.0
species: 180521
type: SpeciesReference

180592
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05629 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)
type: Species

180836
kinetic law: 226218
product: 226206
reactant: 226193
reactant: 226181
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180541
notes: Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1.0
in compartment: 180039
name: Ubiquitin
type: Species

181112
constant: true
value: 1.65
type: Parameter

225686
stoichiometry: 1.0
species: 180331
type: SpeciesReference

180872
kinetic law: 226365
product: 226353
reactant: 226341
reactant: 226329
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180572
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05609 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)
type: Species

225903
stoichiometry: 1.0
species: 180481
type: SpeciesReference

181140
constant: true
value: 0.83
type: Parameter

180521
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05616 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1)
type: Species

181102
constant: true
value: 1.97
type: Parameter

180562
constant: false
name: _Beta_-Catenin
initial concentration: NaN
in compartment: 180039
has only substance units: false
boundary condition: false
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
type: Species
is version of: P35222
initial amount: 0.0

225635
stoichiometry: 1.0
species: 180154
type: SpeciesReference

226403
stoichiometry: 1.0
species: 180612
type: SpeciesReference

180755
kinetic law: 225865
product: 225852
reactant: 225839
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true
type: Reaction

226231
stoichiometry: 1.0
species: 180572
type: SpeciesReference

180038
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

226967
stoichiometry: 1.0
species: 180531
type: SpeciesReference

180860
kinetic law: 226316
product: 226304
product: 226292
reactant: 226280
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true
type: Reaction

225839
stoichiometry: 1.0
species: 180431
type: SpeciesReference

181080
constant: true
value: 2.0
type: Parameter

181094
constant: true
value: 0.58
type: Parameter

180990
kinetic law: 226856
product: 226844
reactant: 226832
notes: mass action rate law for first order irreversible reactions, continuous scheme
fast: false
reversible: false
type: Reaction

180491
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05636 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9)
type: Species

181084
constant: true
value: 1.09
type: Parameter

181013
modifier: 227014
reactant: 226943
reactant: 226918
modifier: 227026
reactant: 226931
product: 226990
reactant: 226955
fast: false
kinetic law: 227038
product: 227002
notes: reversible thermodynamically independent convenience kinetics
reversible: true
product: 226967
type: Reaction
product: 226979

181074
constant: true
value: 0.004
type: Parameter

226243
stoichiometry: 1.0
species: 180287
type: SpeciesReference

180451
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05625 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A)
type: Species

181054
constant: true
value: 1.36
type: Parameter

226807
stoichiometry: 1.0
species: 180471
type: SpeciesReference

225545
stoichiometry: 1.0
species: 180674
type: SpeciesReference

181064
constant: true
value: 1.77
type: Parameter

225992
stoichiometry: 1.0
species: 180622
type: SpeciesReference

181096
constant: true
value: 0.92
type: Parameter

225800
stoichiometry: 1.0
species: 180270
type: SpeciesReference

181130
constant: true
value: 0.39
type: Parameter

181044
constant: true
value: 1.15
type: Parameter

226514
stoichiometry: 1.0
species: 180087
type: SpeciesReference

225558
stoichiometry: 1.0
species: 180401
type: SpeciesReference

180170
in compartment: 180039
notes: Long Name: Casein Kinase 1 Synonym: CK1 Accession: P01460
has only substance units: false
boundary condition: false
name: Casein Kinase 1
initial concentration: NaN
constant: false
type: Species
is version of: P54367
initial amount: 1.0

181110
constant: true
value: 0.163
type: Parameter

225584
stoichiometry: 1.0
species: 180087
type: SpeciesReference

BIOMD0000000397
parameter: 181040
species: 180521
reaction: 180812
species: 180572
species: 180441
parameter: 181148
species: 180154
reaction: 180929
curated: true
parameter: 181098
species: 180104
species: 180632
reaction: 180755
species: 180137
species: 180270
parameter: 181144
species: 180511
parameter: 181046
compartment: 180039
species: 180351
parameter: 181140
species: 180087
species: 180381
species: 180411
reaction: 180967
parameter: 181092
species: 180653
species: 180602
species: 180371
parameter: 181146
species: 180321
species: 180187
reaction: 180943
species: 180170
species: 180401
species: 180254
reaction: 180907
parameter: 181142
parameter: 181076
reaction: 180990
name: Sivakumar2011_WntSignalingPathway
species: 180562
parameter: 181056
reaction: 180979
species: 180643
parameter: 181072
reaction: 180707
parameter: 181052
reaction: 180730
parameter: 181094
parameter: 181041
species: 180674
notes: This model is from the article: A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. OMICS 2011 Oct;15(10):729-37. 21978399 , Abstract: The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to in fluence cell fate specification in the developing nervous system. Here we attempt ed to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Ou r model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E (spl)] genes and enhancement of Shh target genes by a SAG agonist that were effec tively demonstrated computationally and were consistent with experimental studies . However, in the case of model simulation of Wnt and EGF pathways, the model net work did not supply any concurrent results with experimental data despite the fac t that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species conne cted by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted th e regulation of a single target gene, Hes-1, based on drug-induced simulations. T hese simulations provided results that matched with experimental studies. Therefo re, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferati on, and differentiation during mammalian central nervous system development. To o ur knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores t he flow of positive and negative regulatory signals modulated by drugs. Note: The secreted protein Wnt activate…
reaction: 180955
species: 180341
species: 180304
parameter: 181080
parameter: 181090
parameter: 181088
reaction: 180766
is version of: GO:0060070
occurs in: http://identifiers.org/taxonomy/40674
parameter: 181128
parameter: 181070
parameter: 181068
parameter: 181078
is: MODEL1101270002
species: 180220
parameter: 181150
parameter: 181084
parameter: 181108
volume units: 142784
species: 180471
parameter: 181058
parameter: 181124
reaction: 180719
parameter: 181064
parameter: 181074
reaction: 181001
reaction: 180684

180071
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell Membrane
type: Compartment

181150
constant: true
value: 1.43
type: Parameter

226255
stoichiometry: 1.0
species: 180582
type: SpeciesReference

181086
constant: true
value: 0.27
type: Parameter

180551
initial amount: 0.0
boundary condition: false
constant: false
in compartment: 180039
initial concentration: NaN
notes: Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
is version of: P35222
name: _Beta_-Catenin
has only substance units: false
type: Species

180341
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05615 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A)
type: Species

180351
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05611 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A)
type: Species

225941
stoichiometry: 1.0
species: 180381
type: SpeciesReference

180612
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05620 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;FRAT#PROTEIN#Frequently rearranged in advanced T-cell lymphomas#P01467#Frequently rearranged in advanced T-cell lymphomas#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT)
type: Species

226341
stoichiometry: 1.0
species: 180187
type: SpeciesReference

181072
constant: true
value: 1.8
type: Parameter

225980
stoichiometry: 1.0
species: 180531
type: SpeciesReference

181052
constant: true
value: 0.85
type: Parameter

181066
constant: true
value: 0.61
type: Parameter

180801
kinetic law: 226066
product: 226054
reactant: 226042
reactant: 226030
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

226575
stoichiometry: 1.0
species: 180220
type: SpeciesReference

180777
kinetic law: 225967
product: 225954
reactant: 225941
reactant: 225929
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

226660
stoichiometry: 1.0
species: 180220
type: SpeciesReference

181098
constant: true
value: 1.45
type: Parameter

225954
stoichiometry: 1.0
species: 180511
type: SpeciesReference

180511
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05623 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;SWI/SNF#PROTEIN#Switched/Sucrose Non Fermentation#P01435#Switched/Sucrose Non Fermentation#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF)
type: Species

225929
stoichiometry: 1.0
species: 180501
type: SpeciesReference

226030
stoichiometry: 1.0
species: 180632
type: SpeciesReference

180812
kinetic law: 226118
product: 226105
product: 226092
reactant: 226079
notes: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
fast: false
reversible: true
type: Reaction

181046
constant: true
value: 0.92
type: Parameter

226624
stoichiometry: 1.0
species: 180451
type: SpeciesReference

226428
stoichiometry: 1.0
species: 180612
type: SpeciesReference

180707
kinetic law: 225673
product: 225660
reactant: 225647
reactant: 225635
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180663
is version of: CHEBI:25750
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.5
in compartment: 180039
name: 6 bromoindirubin 3'oxime
type: Species

180411
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05613 Heterodimer Member Info: TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 4.0
in compartment: 180055
name: Complex_br_(TCF/Smad4)
type: Species

226502
stoichiometry: 1.0
species: 180421
type: SpeciesReference

226563
stoichiometry: 1.0
species: 180592
type: SpeciesReference

226539
stoichiometry: 1.0
species: 180321
type: SpeciesReference

226465
stoichiometry: 1.0
species: 180592
type: SpeciesReference

181078
constant: true
value: 0.036
type: Parameter

181088
constant: true
value: 1.028
type: Parameter

181108
constant: true
value: 0.854
type: Parameter

180441
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05633 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)
type: Species

226758
stoichiometry: 1.0
species: 180391
type: SpeciesReference

226353
stoichiometry: 1.0
species: 180602
type: SpeciesReference

180381
type: Species
name: SWI/SNF
initial concentration: NaN
initial amount: 2.0
is version of: O60264
notes: Long Name: Switched/Sucrose Non Fermentation Synonym: Switched/Sucrose Non Fermentation Accession: P01435
constant: false
has only substance units: false
in compartment: 180055
boundary condition: false

180154
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is version of: O75581
name: LRP5/6
in compartment: 180039
boundary condition: false
notes: Long Name: Low density lipoprotein receptor related protein Synonym: Arrow Accession: P01431
initial amount: 3.0
is version of: O75197

226181
stoichiometry: 1.0
species: 180461
type: SpeciesReference

180461
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05617 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)
type: Species

181050
constant: true
value: 0.81
type: Parameter

180254
in compartment: 180039
notes: Long Name: Diversin Synonym: Ankrd6 Accession: P01466
initial concentration: NaN
initial amount: 1.0
boundary condition: false
name: Diversin
is homolog to: Q8UVT6
type: Species
has only substance units: false
constant: false

181060
constant: true
value: 1.74
type: Parameter

180391
initial concentration: NaN
name: Bcl9
is version of: O00512
in compartment: 180055
initial amount: 2.0
has only substance units: false
notes: Long Name: B-cell lymphoma 9 Synonym: B-cell lymphoma 9,Legless,Lgs Accession: P01450
boundary condition: false
type: Species
constant: false

180481
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05606 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(TCF/Smad4/_br__Beta_-Catenin)
type: Species

225813
stoichiometry: 1.0
species: 180461
type: SpeciesReference

180719
kinetic law: 225724
product: 225711
reactant: 225698
reactant: 225686
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

226329
stoichiometry: 1.0
species: 180592
type: SpeciesReference

180943
reversible: true
product: 226660
fast: false
type: Reaction
reactant: 226624
reactant: 226636
modifier: 226672
notes: reversible rapid-equilibrium random order ternary-complex mechanism with two products
kinetic law: 226684
product: 226648

227002
stoichiometry: 1.0
species: 180220
type: SpeciesReference

181134
constant: true
value: 0.7
type: Parameter

181048
constant: true
value: 1.31
type: Parameter

180055
constant: true
size: 1.0
spatial dimensions: 3.0
name: Nucleus
type: Compartment

181120
constant: true
value: 1.62
type: Parameter

226709
stoichiometry: 1.0
species: 180361
type: SpeciesReference

226042
stoichiometry: 1.0
species: 180541
type: SpeciesReference

226832
stoichiometry: 1.0
species: 180562
type: SpeciesReference

181076
constant: true
value: 1.99
type: Parameter

226990
stoichiometry: 1.0
species: 180220
type: SpeciesReference

180674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Complex_br_(Bcl9/Pygo/../Smad4)
type: Species

180304
initial concentration: NaN
has only substance units: false
name: FRAT
notes: Long Name: Frequently rearranged in advanced T-cell lymphomas Synonym: Frequently rearranged in advanced T-cell lymphomas Accession: P01467
boundary condition: false
type: Species
in compartment: 180039
constant: false
is version of: Q92837
initial amount: 3.0

226746
stoichiometry: 1.0
species: 180481
type: SpeciesReference

180237
boundary condition: false
initial concentration: NaN
initial amount: 0.0
notes: Long Name: Glycogen Synthase Kinase-3Beta Synonym: GSK3B,GSK3Beta,Sgg,Shaggy,Zeste White 3,Zw3 Accession: P01441
in compartment: 180039
is version of: P49841
constant: false
has only substance units: false
type: Species
name: Glycogen Synthase Kinase-3_Beta_

226551
stoichiometry: 1.0
species: 180204
type: SpeciesReference

180695
kinetic law: 225622
product: 225609
reactant: 225596
reactant: 225584
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
fast: false
reversible: true
type: Reaction

180602
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05641 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;Frodo#PROTEIN#Frodo#P01470#frd#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)
type: Species

226477
stoichiometry: 1.0
species: 180170
type: SpeciesReference

181062
constant: true
value: 0.25
type: Parameter

180929
reactant: 226539
reversible: true
product: 226563
modifier: 226599
notes: reversible rapid-equilibrium random order ternary-complex mechanism with two products
fast: false
product: 226575
type: Reaction
kinetic law: 226611
modifier: 226587
reactant: 226551

180622
constant: false
boundary condition: false
is homolog to: Q91854
name: _beta_TrCP
in compartment: 180039
initial concentration: NaN
notes: Long Name: betaTransducin repeat-containing protein Synonym: BTrCP,Beta Transducin Repeat-Containing Protein,Slimb Accession: P01454
type: Species
initial amount: 2.0
has only substance units: false

226390
stoichiometry: 1.0
species: 180304
type: SpeciesReference

226378
stoichiometry: 1.0
species: 180602
type: SpeciesReference

226931
stoichiometry: 1.0
species: 180204
type: SpeciesReference

180401
notes: Long Name: Wnt Target Genes Synonym: Axin,Conductin,CyclinD1,En-2,ID2,MMP7,Myc,Naked,Nkd,PPAR Delta,Siamois,TCF-1,Twin,Ubx,Xbra,Xnr3 Accession: G01558
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180055
name: Wnt Target Genes
type: Species

181132
constant: true
value: 1.278
type: Parameter

225852
stoichiometry: 1.0
species: 180471
type: SpeciesReference

225596
stoichiometry: 1.0
species: 180120
type: SpeciesReference

225660
stoichiometry: 1.0
species: 180137
type: SpeciesReference

225749
stoichiometry: 1.0
species: 180254
type: SpeciesReference

181122
constant: true
value: 0.05
type: Parameter

225698
stoichiometry: 1.0
species: 180431
type: SpeciesReference

226844
stoichiometry: 1.0
species: 180471
type: SpeciesReference

181148
constant: true
value: 0.7
type: Parameter

180918
kinetic law: 226526
product: 226514
reactant: 226502
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true
type: Reaction

180421
has only substance units: false
boundary condition: false
type: Species
in compartment: 180071
is homolog to: A4F2Q1
notes: Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444
constant: false
initial concentration: NaN
name: Wnt
initial amount: 5.0

180653
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05627 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 180039
name: Complex_br_(_beta_TrCP/_Beta_-Catenin)
type: Species

225788
stoichiometry: 1.0
species: 180441
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

W3 CDTF: Fri Apr 20 20:39:01 BST 2012

W3 CDTF: Wed Nov 02 14:46:25 GMT 2011

orgname: Rajiv Gandhi Centre for Biotechnology

given: KC
family: Sivakumar