209492
stoichiometry: 1.0
species: 142705
type: SpeciesReference

142616
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol
type: Compartment

143731
constant: true
value: 1.0
type: Parameter

143193
type: Species
notes: Long Name: Long Name: Delta and Notch (fucosylated) Synonym: Synonym not specified Accession: U05411 Heterodimer Member Info: Notch#PROTEIN#Notch#P01099#GLP-1|LIN-12|Notch1|Notch2|Notch3|Notch4#;Delta#PROTEIN#Delta#P01116#Delta-like1|Delta-like3|Delta-like4|DeltaC|LAG-2#
constant: false
initial concentration: NaN
name: Complex_br_(Notch/Delta)
is version of: GO:0043234
has only substance units: false
in compartment: 142616
initial amount: 0.0
boundary condition: false

143695
constant: true
value: 0.04
type: Parameter

142651
is version of: Q8NES3
constant: false
notes: Long Name: Fringe Synonym: Lunatic Fringe,Manic Fringe,Radical Fringe Accession: P01107
in compartment: 142613
initial concentration: NaN
initial amount: 5.0
name: Fringe
type: Species
boundary condition: false
has only substance units: false

210236
stoichiometry: 1.0
species: 143245
type: SpeciesReference

143707
constant: true
value: 1.0
type: Parameter

209516
stoichiometry: 1.0
species: 143138
type: SpeciesReference

209420
stoichiometry: 1.0
species: 142866
type: SpeciesReference

210176
stoichiometry: 1.0
species: 143030
type: SpeciesReference

143830
constant: true
value: 2.0
type: Parameter

143227
is version of: CCO:U0000005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 5.0
in compartment: 142613
name: s76
type: Species

209672
stoichiometry: 1.0
species: 142849
type: SpeciesReference

143120
in compartment: 142613
initial amount: 0.0
initial concentration: NaN
has only substance units: false
name: Complex_br_(Serrate/N_sub_ext)
boundary condition: false
constant: false
is version of: GO:0043234
type: Species
notes: Long Name: Long Name: Serrate and Notch extracellular fragment Synonym: Synonym not specified Accession: U05414 Heterodimer Member Info: Next#PROTEIN#Serrate and Notch extracellular fragment#P01103##;Serrate#PROTEIN#Serrate#P01104#APX-1|F16B12.2|Jagged1|Jagged2#

143674
constant: true
value: 0.5
type: Parameter

143770
constant: true
value: 1.0
type: Parameter

209612
stoichiometry: 1.0
species: 142902
type: SpeciesReference

143746
constant: true
value: 1.5
type: Parameter

BIOMD0000000396
parameter: 143692
parameter: 143701
species: 142992
parameter: 143740
curated: true
parameter: 143776
parameter: 143824
parameter: 143815
parameter: 143686
reaction: 143406
reaction: 143340
parameter: 143764
species: 143227
occurs in: CL:0000047
species: 143085
species: 143209
parameter: 143803
parameter: 143674
species: 142687
species: 142902
reaction: 143561
reaction: 143492
parameter: 143839
species: 143282
species: 142957
substance units: 142808
reaction: 143429
parameter: 143710
compartment: 142616
parameter: 143749
reaction: 143320
parameter: 143785
species: 142760
length unit: length
parameter: 143779
parameter: 143695
occurs in: http://identifiers.org/taxonomy/40674
parameter: 143818
species: 143120
species: 143102
reaction: 143451
parameter: 143728
species: 142831
species: 142814
species: 142975
parameter: 143758
parameter: 143713
reaction: 143515
compartment: 142633
parameter: 143794
parameter: 143788
reaction: 143629
volume units: 142784
species: 143048
parameter: 143836
parameter: 143827
parameter: 143698
species: 142921
parameter: 143707
parameter: 143689
species: 142777
parameter: 143833
reaction: 143363
parameter: 143737
species: 143193
parameter: 143743
compartment: 142613
parameter: 143734
species: 142884
parameter: 143773
reaction: 143538
name: Sivakumar2011_NotchSignalingPathway
time units: 949038
species: 142866
species: 142651
species: 142740
type: SBMLModel
parameter: 143770
parameter: 143722
area units: 498119

142613
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

143683
constant: true
value: 2.0
type: Parameter

143012
constant: false
in compartment: 142616
notes: Long Name: Notch Synonym: GLP-1,LIN-12,Notch1,Notch2,Notch3,Notch4 Accession: P01099
initial concentration: NaN
type: Species
is version of: Q6IAD4
initial amount: 5.0
has only substance units: false
boundary condition: false
name: Notch

143451
notes: reversible rapid-equilibrium random order ternary-complex mechanism with one product
type: Reaction
modifier: 209816
fast: false
product: 209804
reactant: 209780
reversible: true
kinetic law: 209828
reactant: 209792

142866
type: Species
in compartment: 142633
name: Complex_br_(Su(H)/CoR)
notes: Long Name: Long Name: Suppressor of Hairless and Co-repressors Synonym: Synonym not specified Accession: U05412 Heterodimer Member Info: Su(H)#PROTEIN#Suppressor of Hairless [Su(H)]#P01101#C-promoter binding factor 1|CBF1|IKJRB1|Immunoglobulin Kappa J region recombination signal-binding protein 1|LAG-1#;CoR#PROTEIN#Co-repressors#P01112##
constant: false
initial amount: 0.0
boundary condition: false
is version of: GO:0043234
has only substance units: false
initial concentration: NaN

142992
initial concentration: NaN
in compartment: 142633
initial amount: 0.0
has only substance units: false
type: Species
constant: false
notes: Long Name: a46_degraded Synonym: Synonym not specified Accession: U02510
name: a46_degraded
is: CHEBI:36080
boundary condition: false

209720
stoichiometry: 1.0
species: 142831
type: SpeciesReference

143677
constant: true
value: 1.0
type: Parameter

143743
constant: true
value: 1.5
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

142814
has only substance units: false
boundary condition: false
name: Mastermind
initial concentration: NaN
constant: false
is version of: Q92585
notes: Long Name: Mastermind Synonym: MECT-1,Mastermind-like 1 (MAML1),Mastermind-like2 (MAML2),Mastermind-like3(MAML3),mucoepidermoid carcinoma-translocated 1 Accession: P01106
in compartment: 142633
type: Species
initial amount: 0.5

143538
notes: reversible simple convenience kinetics
reversible: true
fast: false
product: 210008
kinetic law: 210044
modifier: 210032
reactant: 209996
type: Reaction
product: 210020

210188
stoichiometry: 1.0
species: 142705
type: SpeciesReference

142938
is version of: GO:0043234
notes: Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120
constant: false
type: Species
boundary condition: false
initial amount: 0.0
initial concentration: NaN
has only substance units: false
in compartment: 142633
name: NI_sub_c_sub_s

209888
stoichiometry: 1.0
species: 142670
type: SpeciesReference

210248
stoichiometry: 1.0
species: 143282
type: SpeciesReference

143719
constant: true
value: 1.5
type: Parameter

143209
initial amount: 0.0
in compartment: 142633
name: E(spl)-C genes
has only substance units: false
notes: Long Name: Enhancer of Split complex genes Synonym: Synonym not specified Accession: G01541
is homolog to: Q5S414
type: Species
constant: false
boundary condition: false
initial concentration: NaN

209600
stoichiometry: 1.0
species: 143138
type: SpeciesReference

143782
constant: true
value: 1.5
type: Parameter

143734
constant: true
value: 1.0
type: Parameter

143030
type: Species
initial amount: 0.0
is version of: GO:0043234
in compartment: 142613
notes: Long Name: Long Name: Delta and Notch extracellular fragment Synonym: Synonym not specified Accession: U05409 Heterodimer Member Info: Next#PROTEIN#Serrate and Notch extracellular fragment#P01103##;Delta#PROTEIN#Delta#P01116#Delta-like1|Delta-like3|Delta-like4|DeltaC|LAG-2#
initial concentration: NaN
boundary condition: false
constant: false
has only substance units: false
name: Complex_br_(Delta/N_sub_ext)

143384
kinetic law: 209636
modifier: 209624
product: 209612
reactant: 209600
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true
type: Reaction

209900
stoichiometry: 1.0
species: 143048
type: SpeciesReference

143806
constant: true
value: 1.28
type: Parameter

143606
modifier: 210200
type: Reaction
notes: reversible simple convenience kinetics
product: 210188
reversible: true
fast: false
reactant: 210164
product: 210176
kinetic law: 210212

143363
kinetic law: 209588
modifier: 209576
product: 209564
reactant: 209552
notes: kinetics of non-modulated unireactant enzymes
fast: false
reversible: true
type: Reaction

143282
name: gama secretase
has part: Q9NZ42
has part: Q96BI3
boundary condition: false
has only substance units: false
constant: false
in compartment: 142613
initial concentration: NaN
initial amount: 0.0
type: Species

143821
constant: true
value: 1.87
type: Parameter

209456
stoichiometry: 1.0
species: 142921
type: SpeciesReference

210128
stoichiometry: 1.0
species: 143193
type: SpeciesReference

209732
stoichiometry: 1.0
species: 142814
type: SpeciesReference

143755
constant: true
value: 1.0
type: Parameter

143749
constant: true
value: 1.0
type: Parameter

143085
in compartment: 142613
initial amount: 5.0
name: Serrate
has only substance units: false
boundary condition: false
initial concentration: NaN
type: Species
notes: Long Name: Serrate Synonym: APX-1,F16B12.2,Jagged1,Jagged2 Accession: P01104
is homolog to: Q6SPF9
constant: false

ORG:
  orgname: Rajiv Gandhi Centre for Biotechnology
n:
  given: KC
  family: Sivakumar

143800
constant: true
value: 1.48
type: Parameter

142777
boundary condition: false
initial concentration: NaN
notes: Long Name: Neuralized Synonym: Neu Accession: P01117
has only substance units: false
name: Neuralized
initial amount: 0.5
in compartment: 142613
type: Species
is version of: Q9BR09
constant: false

143680
constant: true
value: 1.5
type: Parameter

209804
stoichiometry: 1.0
species: 142938
type: SpeciesReference

210020
stoichiometry: 1.0
species: 142705
type: SpeciesReference

143794
constant: true
value: 1.61
type: Parameter

142723
name: N_sub_tm
constant: false
has only substance units: false
initial concentration: NaN
in compartment: 142616
boundary condition: false
initial amount: 0.0
type: Species
notes: Long Name: Notch transmembrane domain fragment Synonym: Synonym not specified Accession: P01114
is version of: GO:0043234

209780
stoichiometry: 1.0
species: 142902
type: SpeciesReference

143515
reversible: true
type: Reaction
kinetic law: 209984
fast: false
reactant: 209948
reactant: 209936
product: 209960
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
modifier: 209972

143704
constant: true
value: 0.01
type: Parameter

209432
stoichiometry: 1.0
species: 143209
type: SpeciesReference

209504
stoichiometry: 1.0
species: 142723
type: SpeciesReference

209996
stoichiometry: 1.0
species: 143102
type: SpeciesReference

210224
stoichiometry: 1.0
species: 143227
type: SpeciesReference

143833
constant: true
value: 0.004
type: Parameter

143340
type: Reaction
reactant: 209492
product: 209504
kinetic law: 209540
notes: reversible simple convenience kinetics
product: 209516
reversible: true
modifier: 209528
fast: false

209468
stoichiometry: 1.0
species: 143209
type: SpeciesReference

143102
notes: Long Name: Long Name: Serrate and Notch (fucosylated) Synonym: Synonym not specified Accession: U05410 Heterodimer Member Info: Notch#PROTEIN#Notch#P01099#GLP-1|LIN-12|Notch1|Notch2|Notch3|Notch4#;Serrate#PROTEIN#Serrate#P01104#APX-1|F16B12.2|Jagged1|Jagged2#
boundary condition: false
initial concentration: NaN
has only substance units: false
name: Complex_br_(Serrate/Notch)
initial amount: 0.0
type: Species
constant: false
in compartment: 142616
is version of: GO:0043234

143737
constant: true
value: 1.0
type: Parameter

143767
constant: true
value: 1.5
type: Parameter

143791
constant: true
value: 1.0
type: Parameter

209744
stoichiometry: 1.0
species: 142884
type: SpeciesReference

143803
constant: true
value: 1.64
type: Parameter

143492
reversible: true
kinetic law: 209924
modifier: 209912
type: Reaction
notes: reversible rapid-equilibrium random order ternary-complex mechanism with one product
reactant: 209888
fast: false
reactant: 209876
product: 209900

143245
is version of: CCO:U0000005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 5.0
in compartment: 142613
name: s77
type: Species

143692
constant: true
value: 1.0
type: Parameter

143758
constant: true
value: 1.5
type: Parameter

143429
product: 209756
reactant: 209708
kinetic law: 209768
reversible: true
reactant: 209720
type: Reaction
reactant: 209744
fast: false
reactant: 209732
notes: mass action rate law for , reversible reactions, continuous scheme

143779
constant: true
value: 1.25
type: Parameter

142796
has only substance units: false
constant: false
is homolog to: P49757
boundary condition: false
name: Numb
initial concentration: NaN
notes: Long Name: Numb Synonym: Synonym not specified Accession: P01118
type: Species
initial amount: 0.64
in compartment: 142616

143716
constant: true
value: 0.5
type: Parameter

209792
stoichiometry: 1.0
species: 142975
type: SpeciesReference

143301
kinetic law: 209444
product: 209432
reactant: 209420
fast: false
reversible: false
type: Reaction

142705
type: Species
initial concentration: NaN
has only substance units: false
is version of: GO:0043234
boundary condition: false
constant: false
name: NI_sub_c_sub_t
in compartment: 142616
notes: Long Name: Notch intracellular tethered fragment Synonym: Synonym not specified Accession: P01119
initial amount: 5.0

209648
stoichiometry: 1.0
species: 142866
type: SpeciesReference

209840
stoichiometry: 1.0
species: 142938
type: SpeciesReference

143728
constant: true
value: 2.0
type: Parameter

143582
notes: reversible rapid-equilibrium random order ternary-complex mechanism with one product
fast: false
reactant: 210104
modifier: 210140
product: 210128
type: Reaction
kinetic law: 210152
reversible: true
reactant: 210116

142831
initial concentration: NaN
name: Su(H)
has only substance units: false
in compartment: 142633
constant: false
type: Species
boundary condition: false
notes: Long Name: Suppressor of Hairless [Su(H)] Synonym: C-promoter binding factor 1,CBF1,IKJRB1,Immunoglobulin Kappa J region recombination signal-binding protein 1,LAG-1 Accession: P01101
initial amount: 5.0
is version of: P28159

142670
constant: false
notes: Long Name: Fucose Synonym: Synonym not specified Accession: S01795
has only substance units: false
initial concentration: NaN
name: fucose
is version of: CHEBI:18287
in compartment: 142613
initial amount: 5.0
type: Species
boundary condition: false

143788
constant: true
value: 1.7
type: Parameter

143812
constant: true
value: 1.61
type: Parameter

143067
boundary condition: false
in compartment: 142613
initial concentration: NaN
is homolog to: Q9V6X7
initial amount: 5.0
has only substance units: false
type: Species
notes: Long Name: Neurotic Synonym: O-fucosyltransferase 1,O-fut1,OFUT1,Ofut1 Accession: P01115
constant: false
name: Neurotic

143725
constant: true
value: 0.5
type: Parameter

143797
constant: true
value: 1.71
type: Parameter

143827
constant: true
value: 0.055
type: Parameter

143752
constant: true
value: 1.5
type: Parameter

209552
stoichiometry: 1.0
species: 142687
type: SpeciesReference

143561
kinetic law: 210092
modifier: 210080
product: 210068
reactant: 210056
notes: kinetics of non-modulated unireactant enzymes
fast: false
reversible: true
type: Reaction

210116
stoichiometry: 1.0
species: 143048
type: SpeciesReference

143406
notes: reversible simple convenience kinetics
reactant: 209648
type: Reaction
product: 209672
modifier: 209684
kinetic law: 209696
fast: false
product: 209660
reversible: true

142633
constant: true
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

143824
constant: true
value: 1.95
type: Parameter

210056
stoichiometry: 1.0
species: 142796
type: SpeciesReference

143776
constant: true
value: 1.5
type: Parameter

209708
stoichiometry: 1.0
species: 142902
type: SpeciesReference

209756
stoichiometry: 1.0
species: 142921
type: SpeciesReference

142687
name: Delta
boundary condition: false
has only substance units: false
is version of: O00548
initial amount: 5.0
constant: false
type: Species
notes: Long Name: Delta Synonym: Delta-like1,Delta-like3,Delta-like4,DeltaC,LAG-2 Accession: P01116
initial concentration: NaN
in compartment: 142613

143764
constant: true
value: 1.5
type: Parameter

143815
constant: true
value: 1.78
type: Parameter

142902
has only substance units: false
notes: Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120
is version of: GO:0043234
boundary condition: false
initial amount: 0.0
constant: false
initial concentration: NaN
in compartment: 142633
name: NI_sub_c_sub_s
type: Species

209852
stoichiometry: 1.0
species: 142992
type: SpeciesReference

142957
boundary condition: false
is homolog to: Q9UBV2
notes: Long Name: Sel 10 Synonym: Synonym not specified Accession: P01102
type: Species
name: Sel 10
initial concentration: NaN
in compartment: 142633
initial amount: 0.6
has only substance units: false
constant: false

143629
reactant: 210224
modifier: 210260
product: 210248
type: Reaction
notes: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
reversible: true
fast: false
reactant: 210236
kinetic law: 210272

210104
stoichiometry: 1.0
species: 142687
type: SpeciesReference

143713
constant: true
value: 1.0
type: Parameter

142884
boundary condition: false
is version of: CHEBI:36080
name: CoA
initial concentration: NaN
notes: Long Name: Co-Activators Synonym: Synonym not specified Accession: P01100
constant: false
initial amount: 0.5
in compartment: 142633
has only substance units: false
type: Species

142760
boundary condition: false
name: a7_degraded
constant: false
initial amount: 0.0
notes: Long Name: a7_degraded Synonym: Synonym not specified Accession: U02511
initial concentration: NaN
type: Species
is: CHEBI:36080
has only substance units: false
in compartment: 142613

143156
notes: Long Name: a25_degraded Synonym: Synonym not specified Accession: U02509
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 142616
name: a25_degraded
type: Species

143761
constant: true
value: 1.5
type: Parameter

143809
constant: true
value: 1.86
type: Parameter

143836
constant: true
value: 2.0
type: Parameter

210068
stoichiometry: 1.0
species: 143156
type: SpeciesReference

209948
stoichiometry: 1.0
species: 143085
type: SpeciesReference

143698
constant: true
value: 0.05
type: Parameter

143722
constant: true
value: 1.0
type: Parameter

143263
is version of: CCO:U0000005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 142613
name: dapt
type: Species

143138
in compartment: 142616
is version of: GO:0043234
name: NI_sub_c_sub_s
type: Species
initial amount: 0.0
boundary condition: false
has only substance units: false
notes: Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120
initial concentration: NaN
constant: false

143701
constant: true
value: 2.0
type: Parameter

143689
constant: true
value: 1.5
type: Parameter

143320
kinetic law: 209480
product: 209468
reactant: 209456
fast: false
reversible: false
type: Reaction

142921
initial amount: 0.0
initial concentration: NaN
in compartment: 142633
type: Species
name: Complex_br_(Mastermind/Su(H)/_br_CoA/NI_sub_c_sub_s)
is version of: GO:0043234
boundary condition: false
notes: Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05413 Heterodimer Member Info: CoA#PROTEIN#Co-Activators#P01100##;Su(H)#PROTEIN#Suppressor of Hairless [Su(H)]#P01101#C-promoter binding factor 1|CBF1|IKJRB1|Immunoglobulin Kappa J region recombination signal-binding protein 1|LAG-1#;Mastermind#PROTEIN#Mastermind#P01106#MECT-1|Mastermind-like 1 (MAML1)|Mastermind-like2 (MAML2)|Mastermind-like3(MAML3)|mucoepidermoid carcinoma-translocated 1#;NIcs#PROTEIN#Notch intracellular soluble fragment#P01120##
has only substance units: false
constant: false

143773
constant: true
value: 1.5
type: Parameter

143818
constant: true
value: 0.15
type: Parameter

143686
constant: true
value: 1.5
type: Parameter

143710
constant: true
value: 0.5
type: Parameter

209960
stoichiometry: 1.0
species: 143102
type: SpeciesReference

143174
notes: Long Name: LNXp80 Synonym: Ligand of Numb-protein X 80 kDa Accession: P01111
has only substance units: false
initial amount: 0.33
initial concentration: NaN
in compartment: 142616
boundary condition: false
type: Species
constant: false
name: LNXp80
is homolog to: O70263

142849
notes: Long Name: Co-repressors Synonym: Synonym not specified Accession: P01112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 5.0
in compartment: 142633
name: CoR
type: Species

210008
stoichiometry: 1.0
species: 143120
type: SpeciesReference

209660
stoichiometry: 1.0
species: 142831
type: SpeciesReference

209936
stoichiometry: 1.0
species: 143048
type: SpeciesReference

143048
in compartment: 142616
boundary condition: false
initial amount: 0.0
type: Species
name: Notch
notes: Long Name: Notch Synonym: GLP-1,LIN-12,Notch1,Notch2,Notch3,Notch4 Accession: P01099
constant: false
has only substance units: false
initial concentration: NaN
is version of: Q6IAD4

209876
stoichiometry: 1.0
species: 143012
type: SpeciesReference

210164
stoichiometry: 1.0
species: 143193
type: SpeciesReference

209564
stoichiometry: 1.0
species: 142760
type: SpeciesReference

142740
is version of: Q8TE56
initial amount: 0.5
has only substance units: false
initial concentration: NaN
in compartment: 142616
name: TACE
notes: Long Name: TACE Synonym: A disintegrin and metalloproteinase domain 17,ADAM17,Tumor necrosis factor alpha converting enzyme Accession: P01105
boundary condition: false
constant: false
type: Species

142975
boundary condition: false
type: Species
initial amount: 0.5
notes: Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01796
constant: false
initial concentration: NaN
name: Ub
in compartment: 142633
is: CCO:F0004655
has only substance units: false

143839
constant: true
value: 0.00594
type: Parameter

143473
kinetic law: 209864
product: 209852
reactant: 209840
notes: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
fast: false
reversible: true
type: Reaction

143785
constant: true
value: 0.5
type: Parameter

143740
constant: true
value: 1.0
type: Parameter

W3 CDTF: Fri Apr 20 20:39:34 BST 2012

W3 CDTF: Wed Nov 02 14:45:45 GMT 2011