mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05229 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2#
This model is from the article: A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. OMICS 2011 Oct;15(10):729-37. 21978399 , Abstract: The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to in fluence cell fate specification in the developing nervous system. Here we attempt ed to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Ou r model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E (spl)] genes and enhancement of Shh target genes by a SAG agonist that were effec tively demonstrated computationally and were consistent with experimental studies . However, in the case of model simulation of Wnt and EGF pathways, the model net work did not supply any concurrent results with experimental data despite the fac t that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species conne cted by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted th e regulation of a single target gene, Hes-1, based on drug-induced simulations. T hese simulations provided results that matched with experimental studies. Therefo re, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferati on, and differentiation during mammalian central nervous system development. To o ur knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores t he flow of positive and negative regulatory signals modulated by drugs. Note: This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the identities of individual target genes have not been listed. The main difference between the Drosophila and mammalian Hedgehog signaling pathways is the fact that there are three mammalian homologs of Cubitus interruptus, Gli1 Gli2 and Gli3. Some or all of the mammalian homologs may be proteolytically processed, but the data are controversial. There are two mammalian Ptc genes and three mammalian Hedgehog genes as well. The pathway for Sonic Hedgehog appears to be most similar to the Drosophila hedgehog pathway. Eg: 11731473 , 11861165 , 12200154 & 14738752 .
Long Name: Long Name: Smoothened Synonym: Synonym not specified Accession: U05226 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05228 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2#
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05221 Heterodimer Member Info: Hedgehog#PROTEIN#Hedgehog#P00688#Hh|Shh|Sonic hedgehog#;Patched#PROTEIN#Patched#P00689#Ptc|Ptc1#
mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
Long Name: Hedgehog Synonym: Hh,Shh,Sonic hedgehog Accession: P00688
kinetics of non-modulated unireactant enzymes
reversible rapid-equilibrium random order ternary-complex mechanism with two products
mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
Long Name: Cubitus interruptus Synonym: Ci,CiFL,Gli1,Gli2,Gli3 Accession: P00690
Long Name: ADP Synonym: Synonym not specified Accession: S01693
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05220 Heterodimer Member Info: Cubitus interruptus repressor#PROTEIN#Cubitus interruptus repressor#P00687#CiR#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused#
Long Name: CBP Synonym: CREB binding protein,p300 Accession: P00691
Long Name: ATP Synonym: Synonym not specified Accession: S01691
Long Name: Microtubule Synonym: Synonym not specified Accession: P00696
Long Name: Patched Synonym: Ptc,Ptc1 Accession: P00689
Long Name: e.g., ptc Synonym: Synonym not specified Accession: G01526
mass action rate law for second order irreversible reactions, two reactants, continuous scheme
Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05217 Heterodimer Member Info: Cubitus interruptus repressor#PROTEIN#Cubitus interruptus repressor#P00687#CiR#;Sap18#PROTEIN#Sap18#P00697#Sin3-associated polypeptide 18#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused#
Long Name: Sap18 Synonym: Sin3-associated polypeptide 18 Accession: P00697