512134
stoichiometry: 1.0
species: 982779
type: SpeciesReference

982778
is version of: GO:0005739
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: mito
type: Compartment

982856
constant: true
value: 0.03
name: UniPort
type: Parameter

982796
kinetic law: 512122
modifier: 512110
product: 512098
is version of: GO:0032959
fast: false
reversible: false
name: PLC: Receptor and Ca2+ regulated IP3 production
type: Reaction

982842
constant: true
value: 0.175
name: kIP3R
type: Parameter

982783
initial concentration: NaN
constant: false
in compartment: 982767
has only substance units: false
name: IP3
is version of: C01255
is version of: CHEBI:16595
is: SBO:0000247
boundary condition: false
initial amount: 0.0
type: Species

982857
constant: true
value: 0.6
name: kUniP
type: Parameter

982795
in compartment: 982778
is version of: C00076
type: Species
initial amount: 0.0
is version of: CHEBI:29108
is: SBO:0000247
initial concentration: NaN
has only substance units: false
name: CaM
constant: false
boundary condition: false

512098
stoichiometry: 1.0
species: 982783
type: SpeciesReference

982838
constant: true
value: 0.175
name: kSERCA
type: Parameter

512413
stoichiometry: 1.0
species: 982795
type: SpeciesReference

512255
stoichiometry: 1.0
species: 982787
type: SpeciesReference

512449
stoichiometry: 1.0
species: 982791
type: SpeciesReference

982837
constant: true
value: 0.018
name: IP3Rrecovery
type: Parameter

982854
constant: true
value: 0.005
name: MitNaCaEx
type: Parameter

982844
constant: true
value: 0.0346
name: PMleak
type: Parameter

982804
is version of: GO:0051209
reversible: false
product: 512183
fast: false
modifier: 512195
modifier: 512207
reactant: 512170
name: IP3R: IP3 and Ca2+ regulated Ca2+ channel, plus leak
type: Reaction
kinetic law: 512219

982819
kinetic law: 512437
product: 512425
reactant: 512413
is version of: GO:0006851
fast: false
reversible: false
name: MitoToCytosol
type: Reaction

982779
boundary condition: false
is version of: CHEBI:29108
is version of: C00076
name: CaI
is: SBO:0000247
initial amount: 0.05
initial concentration: NaN
type: Species
in compartment: 982767
has only substance units: false
constant: false

982836
constant: true
value: 5.0
name: IP3Rinhibition
type: Parameter

512377
stoichiometry: 1.0
species: 982779
type: SpeciesReference

512183
stoichiometry: 1.0
species: 982779
type: SpeciesReference

982845
constant: true
value: 1.0
name: kSTIM
type: Parameter

512317
stoichiometry: 1.0
species: 982779
type: SpeciesReference

982831
constant: true
value: 3.0
name: IP3R
type: Parameter

982816
kinetic law: 512365
reactant: 512353
is version of: GO:0006816
fast: false
reversible: false
name: PMCA: Pumps Ca2+ across PM out of cell
type: Reaction

982774
is version of: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: ER_store
type: Compartment

512389
stoichiometry: 1.0
species: 982795
type: SpeciesReference

982852
constant: true
value: 1.0
name: kG
type: Parameter

982846
constant: true
value: 0.02
name: STIM
type: Parameter

982811
kinetic law: 512280
modifier: 512267
product: 512255
is version of: GO:0031586
fast: false
reversible: false
name: Inhibition of IP3R (mechanism not well understood)
type: Reaction

512462
stoichiometry: 1.0
species: 982795
type: SpeciesReference

982773
is version of: GO:0005576
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: Outside
type: Compartment

982817
kinetic law: 512401
product: 512389
reactant: 512377
is version of: GO:0006851
fast: false
reversible: false
name: UniporterFromCytosol
type: Reaction

982853
constant: true
value: 0.03
name: DirTransf
type: Parameter

982820
fast: false
modifier: 512498
name: ERtoMito
modifier: 512474
modifier: 512486
product: 512462
is version of: GO:0006889
is version of: GO:0006851
type: Reaction
reactant: 512449
reversible: false
kinetic law: 512510

982787
is version of: GO:0019855
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.002
in compartment: 982767
name: g
type: Species

982767
is version of: GO:0005829
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytosol
type: Compartment

982791
is version of: C00076
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: NaN
is version of: CHEBI:29108
constant: false
name: CaS
initial amount: 2.0
in compartment: 982774
boundary condition: false

982800
kinetic law: 512158
product: 512146
reactant: 512134
is version of: GO:0060401
fast: false
reversible: false
name: SERCA: Pumps Ca2+ into ER Ca2+ stores
type: Reaction

BIOMD0000000354
reaction: 982820
notes: This model is from the article: Parallel adaptive feedback enhances reliability of the Ca2+ signaling system. Abell E, Ahrends R, Bandara S, Park BO, Teruel MN. Proc Natl Acad Sci U S A. 2011 Aug 15. 21844332 , Abstract: Despite large cell-to-cell variations in the concentrations of individual signaling proteins, cells transmit signals correctly. This phenomenon raises the question of what signaling systems do to prevent a predicted high failure rate. Here we combine quantitative modeling, RNA interference, and targeted selective reaction monitoring (SRM) mass spectrometry, and we show for the ubiquitous and fundamental calcium signaling system that cells monitor cytosolic and endoplasmic reticulum (ER) Ca(2+) levels and adjust in parallel the concentrations of the store-operated Ca(2+) influx mediator stromal interaction molecule (STIM), the plasma membrane Ca(2+) pump plasma membrane Ca-ATPase (PMCA), and the ER Ca(2+) pump sarco/ER Ca(2+)-ATPase (SERCA). Model calculations show that this combined parallel regulation in protein expression levels effectively stabilizes basal cytosolic and ER Ca(2+) levels and preserves receptor signaling. Our results demonstrate that, rather than directly controlling the relative level of signaling proteins in a forward regulation strategy, cells prevent transmission failure by sensing the state of the signaling pathway and using multiple parallel adaptive feedbacks. Note: There are two models described in the paper to simulate basal and receptor stimulated Ca 2+ signaling. 1) No adaptive feedback (this model: MODEL1108050000) and 2) with three slow adaptive feedback loops (MODEL1108050001).
occurs in: http://identifiers.org/taxonomy/7215
parameter: 982837
parameter: 982832
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
created:
  W3 CDTF: Wed Aug 17 16:56:29 BST 2011
area units: 498119
length unit: length
time units: metaid_0000075
parameter: 982845
compartment: 982773
compartment: 982767
reaction: 982817
parameter: 982842
is described by: http://identifiers.org/pubmed/21844332
species: 982791
substance units: metaid_0000076
compartment: 982778
reaction: 982800
species: 982790
parameter: 982853
reaction: 982804
parameter: 982840
parameter: 982850
parameter: 982856
parameter: 982833
creator:
  ORG:
    orgname: Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305
  n:
    given: Mary N
    family: Teruel
parameter: 982848
species: 982795
is: MODEL1108050000
modified:
  W3 CDTF: Thu Sep 08 13:16:51 BST 2011
reaction: 982807
compartment: 982774
curated: true
reaction: 982815
parameter: 982846
species: 982779
parameter: 982838
reaction: 982811
parameter: 982836
parameter: 982841
parameter: 982857
reaction: 982796
species: 982787
species: 982783
parameter: 982849
parameter: 982844
parameter: 982854
parameter: 982831
reaction: 982816
type: SBMLModel
volume units: 498095
name: Abell2011_CalciumSignaling_WithoutAdaptation
reaction: 982812
is version of: GO:0019722
reaction: 982819
parameter: 982852

982807
kinetic law: 512243
reactant: 512231
is version of: GO:0032961
fast: false
reversible: false
name: IP3 phosphatase: Degradation of IP3
type: Reaction

982833
constant: true
value: 2.0
name: IP3degradation
type: Parameter

512425
stoichiometry: 1.0
species: 982779
type: SpeciesReference

982840
constant: true
value: 0.01
name: ERleak
type: Parameter

982850
constant: true
value: 0.013
name: PMCA
type: Parameter

512170
stoichiometry: 1.0
species: 982791
type: SpeciesReference

982848
constant: true
value: 0.13
name: kIP3Rca
type: Parameter

512146
stoichiometry: 1.0
species: 982791
type: SpeciesReference

982790
has only substance units: false
constant: false
in compartment: 982773
initial concentration: NaN
is: SBO:0000247
type: Species
boundary condition: false
is version of: C00076
initial amount: 1000.0
is version of: CHEBI:29108
name: CaO

512353
stoichiometry: 1.0
species: 982779
type: SpeciesReference

982832
constant: true
value: 0.266
name: SERCA
type: Parameter

982841
constant: true
value: 1.0
name: R
type: Parameter

982815
kinetic law: 512341
modifier: 512329
product: 512317
is version of: GO:0032234
fast: false
reversible: false
name: Regulation of Orai by STIM, plus leak
type: Reaction

512292
stoichiometry: 1.0
species: 982787
type: SpeciesReference

982849
constant: true
value: 0.2
name: kPMCA
type: Parameter

982812
kinetic law: 512305
reactant: 512292
is version of: GO:0031587
fast: false
reversible: false
name: Recovery of IP3R from Ca2+ iinhibition when Ca2+ drops
type: Reaction

512231
stoichiometry: 1.0
species: 982783
type: SpeciesReference