292904
stoichiometry: 1.0
species: 840073
type: SpeciesReference

293764
stoichiometry: 1.0
species: 840107
type: SpeciesReference

293691
stoichiometry: 1.0
species: 840119
type: SpeciesReference

294549
stoichiometry: 1.0
species: 840075
type: SpeciesReference

295406
stoichiometry: 1.0
species: 840125
type: SpeciesReference

840103
is: SBO:0000369
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 2.0
in compartment: 840071
type: Species

295129
stoichiometry: 1.0
species: 840130
type: SpeciesReference

296394
stoichiometry: 1.0
species: 840138
type: SpeciesReference

295077
stoichiometry: 1.0
species: 840127
type: SpeciesReference

293569
stoichiometry: 1.0
species: 840100
type: SpeciesReference

292663
stoichiometry: 1.0
species: 840074
type: SpeciesReference

840196
kinetic law: 294585
type: Reaction
reactant: 294561
is: SBO:0000526
product: 294573
reactant: 294549
reversible: false
fast: false
is version of: GO:0006461

840412
is: SBO:0000009
constant: true
value: 1.0E-8
type: Parameter

840175
product: 293776
fast: false
product: 293788
is: SBO:0000180
kinetic law: 293800
reactant: 293764
type: Reaction
reversible: false
is version of: GO:0032986

295611
stoichiometry: 1.0
species: 840115
type: SpeciesReference

292518
stoichiometry: 1.0
species: 840073
type: SpeciesReference

293060
stoichiometry: 1.0
species: 840086
type: SpeciesReference

840433
constant: false
value: 0.0
type: Parameter

295310
stoichiometry: 1.0
species: 840089
type: SpeciesReference

295923
stoichiometry: 1.0
species: 840131
type: SpeciesReference

294885
stoichiometry: 2.0
species: 840074
type: SpeciesReference

840189
product: 294258
reactant: 294246
reactant: 294234
is version of: GO:0009056
fast: false
kinetic law: 294282
is: SBO:0000179
type: Reaction
product: 294270
reversible: false

292783
stoichiometry: 1.0
species: 840075
type: SpeciesReference

840413
is: SBO:0000009
constant: true
value: 0.01
type: Parameter

840195
kinetic law: 294536
product: 294524
reactant: 294511
is version of: GO:0009056
is: SBO:0000179
fast: false
reversible: false
name: radicalScavenging
type: Reaction

292735
stoichiometry: 1.0
species: 840073
type: SpeciesReference

295418
stoichiometry: 1.0
species: 840093
type: SpeciesReference

295478
stoichiometry: 1.0
species: 840088
type: SpeciesReference

296502
stoichiometry: 1.0
species: 840130
type: SpeciesReference

840178
reactant: 293860
product: 293884
is version of: GO:0032986
reversible: false
type: Reaction
product: 293872
is: SBO:0000180
fast: false
kinetic law: 293896

840228
is: SBO:0000330
product: 295803
kinetic law: 295827
type: Reaction
reversible: false
fast: false
reactant: 295791
is version of: GO:0016311
product: 295815
reactant: 295779

294597
stoichiometry: 1.0
species: 840119
type: SpeciesReference

840105
is: SBO:0000369
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 2.0
in compartment: 840071
type: Species

840430
is: SBO:0000009
constant: false
value: 1.0
type: Parameter

296382
stoichiometry: 1.0
species: 840123
type: SpeciesReference

293000
stoichiometry: 1.0
species: 840075
type: SpeciesReference

840400
is: SBO:0000009
constant: true
value: 0.1
type: Parameter

292675
stoichiometry: 1.0
species: 840076
type: SpeciesReference

840410
is: SBO:0000009
constant: true
value: 6.0E-8
type: Parameter

840119
type: Species
initial concentration: NaN
constant: false
has part: IPR001023
has only substance units: true
initial amount: 100.0
is: SBO:0000297
boundary condition: false
in compartment: 840070
has part: GO:0008287

295370
stoichiometry: 1.0
species: 840089
type: SpeciesReference

840198
product: 294609
fast: false
is version of: GO:0043241
reversible: false
kinetic law: 294633
reactant: 294597
product: 294621
is: SBO:0000180
type: Reaction

294897
stoichiometry: 1.0
species: 840127
type: SpeciesReference

295911
stoichiometry: 1.0
species: 840077
type: SpeciesReference

292771
stoichiometry: 1.0
species: 840074
type: SpeciesReference

840177
is: SBO:0000526
kinetic law: 293848
fast: false
is version of: GO:0006461
reactant: 293812
reactant: 293824
type: Reaction
product: 293836
reversible: false

293654
stoichiometry: 1.0
species: 840101
type: SpeciesReference

840229
is: SBO:0000393
fast: false
reversible: false
is version of: GO:0052064
kinetic law: 295875
type: Reaction
product: 295863
reactant: 295839
product: 295851

840187
product: 294210
fast: false
is version of: GO:0006461
reactant: 294186
reactant: 294198
reversible: false
type: Reaction
kinetic law: 294222
is: SBO:0000526

294609
stoichiometry: 1.0
species: 840075
type: SpeciesReference

840431
is: SBO:0000009
constant: false
value: 1.0
type: Parameter

840421
is: SBO:0000009
constant: true
value: 0.02
type: Parameter

840106
is version of: GO:0043234
is: SBO:0000297
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840071
type: Species

840401
is: SBO:0000009
constant: true
value: 0.08
type: Parameter

293556
stoichiometry: 1.0
species: 840105
type: SpeciesReference

292747
stoichiometry: 1.0
species: 840134
type: SpeciesReference

292831
stoichiometry: 1.0
species: 840074
type: SpeciesReference

840107
constant: false
in compartment: 840071
is version of: GO:0043234
initial concentration: NaN
boundary condition: false
is: SBO:0000297
type: Species
is version of: C00562
has only substance units: true
initial amount: 0.0

840422
is: SBO:0000009
constant: true
value: 0.001
type: Parameter

840236
kinetic law: 296128
product: 296116
reactant: 296104
is version of: GO:0070841
is: SBO:0000177
fast: false
reversible: false
type: Reaction

293144
stoichiometry: 1.0
species: 840094
type: SpeciesReference

840186
fast: false
reactant: 294137
kinetic law: 294174
product: 294149
is version of: GO:0032092
is: SBO:0000177
reversible: false
type: Reaction
product: 294162

840086
constant: false
has part: IPR001404
initial amount: 10.0
boundary condition: false
type: Species
initial concentration: NaN
has part: CHEBI:36080
is: SBO:0000297
has only substance units: true
in compartment: 840070

295466
stoichiometry: 1.0
species: 840093
type: SpeciesReference

293445
stoichiometry: 1.0
species: 840106
type: SpeciesReference

296490
stoichiometry: 1.0
species: 840130
type: SpeciesReference

295719
stoichiometry: 1.0
species: 840115
type: SpeciesReference

294681
stoichiometry: 1.0
species: 840113
type: SpeciesReference

294511
stoichiometry: 1.0
species: 840131
type: SpeciesReference

294561
stoichiometry: 1.0
species: 840114
type: SpeciesReference

840117
is version of: P28562
is: SBO:0000252
boundary condition: false
type: Species
constant: false
is version of: C00562
initial amount: 100.0
initial concentration: NaN
in compartment: 840070
has only substance units: true

295791
stoichiometry: 1.0
species: 840131
type: SpeciesReference

293788
stoichiometry: 1.0
species: 840103
type: SpeciesReference

295514
stoichiometry: 1.0
species: 840093
type: SpeciesReference

294475
stoichiometry: 1.0
species: 840135
type: SpeciesReference

840127
is version of: CHEBI:36080
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

840185
kinetic law: 294125
product: 294113
reactant: 294101
is version of: GO:0006412
is: SBO:0000184
fast: false
reversible: false
type: Reaction

840423
is: SBO:0000009
constant: true
value: 1.0E-4
type: Parameter

840237
reactant: 296153
reactant: 296140
is version of: GO:0070841
product: 296165
reversible: false
is: SBO:0000177
type: Reaction
kinetic law: 296177
fast: false

294861
stoichiometry: 1.0
species: 840117
type: SpeciesReference

840211
kinetic law: 295153
reactant: 295114
fast: false
product: 295129
is version of: GO:0052064
reversible: false
is: SBO:0000393
product: 295141
type: Reaction

292843
stoichiometry: 1.0
species: 840075
type: SpeciesReference

840227
product: 295755
fast: false
is version of: GO:0016310
kinetic law: 295767
product: 295743
reversible: false
type: Reaction
reactant: 295731
reactant: 295719
is: SBO:0000216

296104
stoichiometry: 2.0
species: 840077
type: SpeciesReference

295114
stoichiometry: 1.0
species: 840130
type: SpeciesReference

293544
stoichiometry: 1.0
species: 840109
type: SpeciesReference

840171
fast: false
product: 293630
reversible: false
is: SBO:0000216
product: 293618
reactant: 293606
kinetic law: 293642
is version of: GO:0016310
type: Reaction
reactant: 293594

292940
stoichiometry: 1.0
species: 840075
type: SpeciesReference

840170
is: SBO:0000180
reactant: 293544
is version of: GO:0032986
fast: false
type: Reaction
product: 293556
product: 293569
kinetic law: 293582
reversible: false

840199
reactant: 294657
reversible: false
is version of: GO:0016310
kinetic law: 294693
product: 294669
type: Reaction
is: SBO:0000216
reactant: 294645
fast: false
product: 294681

840118
has part: GO:0000502
type: Species
constant: false
initial concentration: NaN
is: SBO:0000297
in compartment: 840070
has only substance units: true
has part: P28562
initial amount: 0.0
boundary condition: false

293084
stoichiometry: 1.0
species: 840086
type: SpeciesReference

294524
stoichiometry: 1.0
species: 840136
type: SpeciesReference

294801
stoichiometry: 1.0
species: 840123
type: SpeciesReference

295065
stoichiometry: 1.0
species: 840127
type: SpeciesReference

293457
stoichiometry: 1.0
species: 840103
type: SpeciesReference

295394
stoichiometry: 1.0
species: 840092
type: SpeciesReference

840088
is version of: P31749
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 340.0
in compartment: 840070
type: Species

840109
is version of: GO:0043234
is: SBO:0000297
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840071
type: Species

292651
stoichiometry: 1.0
species: 840097
type: SpeciesReference

293156
stoichiometry: 1.0
species: 840096
type: SpeciesReference

840224
reactant: 295623
reactant: 295611
fast: false
product: 295635
is: SBO:0000177
type: Reaction
reversible: false
kinetic law: 295647
is version of: GO:0006461

840174
reactant: 293716
fast: false
is version of: GO:0006461
type: Reaction
reversible: false
reactant: 293728
product: 293740
is: SBO:0000526
kinetic law: 293752

840434
constant: false
value: 0.0
type: Parameter

840098
has only substance units: true
initial amount: 410.0
in compartment: 840070
initial concentration: NaN
is: SBO:0000297
type: Species
boundary condition: false
has part: IPR001404
has part: CHEBI:36080
constant: false

294487
stoichiometry: 1.0
species: 840131
type: SpeciesReference

840115
is version of: P28562
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

295526
stoichiometry: 1.0
species: 840132
type: SpeciesReference

293776
stoichiometry: 1.0
species: 840101
type: SpeciesReference

294573
stoichiometry: 1.0
species: 840119
type: SpeciesReference

840129
is version of: CHEBI:36080
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

840239
kinetic law: 296214
product: 296202
reactant: 296189
is version of: GO:0070841
is: SBO:0000177
fast: false
reversible: false
type: Reaction

840425
is: SBO:0000009
constant: true
value: 1.0E-8
type: Parameter

840089
type: Species
has part: P31749
initial amount: 30.0
has only substance units: true
constant: false
has part: IPR001404
initial concentration: NaN
in compartment: 840070
is: SBO:0000297
boundary condition: false

840183
reversible: false
reactant: 294041
is version of: GO:0009056
is: SBO:0000179
product: 294077
kinetic law: 294089
reactant: 294053
product: 294065
type: Reaction
fast: false

840173
fast: false
reversible: false
product: 293679
kinetic law: 293703
type: Reaction
is version of: GO:0016311
reactant: 293654
is: SBO:0000330
product: 293691
reactant: 293667

840435
constant: false
value: 0.0
type: Parameter

296298
stoichiometry: 2.0
species: 840129
type: SpeciesReference

292795
stoichiometry: 1.0
species: 840098
type: SpeciesReference

840225
is version of: GO:0009056
kinetic law: 295707
reactant: 295671
product: 295695
type: Reaction
reactant: 295659
product: 295683
reversible: false
fast: false
is: SBO:0000179

293494
stoichiometry: 1.0
species: 840100
type: SpeciesReference

293630
stoichiometry: 1.0
species: 840121
type: SpeciesReference

296116
stoichiometry: 1.0
species: 840127
type: SpeciesReference

295539
stoichiometry: 1.0
species: 840125
type: SpeciesReference

840406
is: SBO:0000009
constant: true
value: 0.0015
type: Parameter

294077
stoichiometry: 1.0
species: 840134
type: SpeciesReference

293507
stoichiometry: 1.0
species: 840105
type: SpeciesReference

296442
stoichiometry: 1.0
species: 840113
type: SpeciesReference

293192
stoichiometry: 1.0
species: 840076
type: SpeciesReference

294113
stoichiometry: 1.0
species: 840075
type: SpeciesReference

293836
stoichiometry: 1.0
species: 840110
type: SpeciesReference

295695
stoichiometry: 1.0
species: 840134
type: SpeciesReference

292867
stoichiometry: 1.0
species: 840098
type: SpeciesReference

840077
is version of: IPR001023
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

840426
is: SBO:0000009
constant: true
value: 1.5E-7
type: Parameter

293036
stoichiometry: 1.0
species: 840076
type: SpeciesReference

294451
stoichiometry: 1.0
species: 840134
type: SpeciesReference

294306
stoichiometry: 1.0
species: 840125
type: SpeciesReference

294837
stoichiometry: 1.0
species: 840117
type: SpeciesReference

293421
stoichiometry: 1.0
species: 840106
type: SpeciesReference

840427
is: SBO:0000009
constant: true
value: 1.5E-7
type: Parameter

840076
is version of: IPR001404
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1850.0
in compartment: 840070
type: Species

293096
stoichiometry: 1.0
species: 840076
type: SpeciesReference

294414
stoichiometry: 1.0
species: 840126
type: SpeciesReference

294993
stoichiometry: 2.0
species: 840129
type: SpeciesReference

296430
stoichiometry: 1.0
species: 840113
type: SpeciesReference

296226
stoichiometry: 1.0
species: 840079
type: SpeciesReference

294101
stoichiometry: 1.0
species: 840135
type: SpeciesReference

293180
stoichiometry: 1.0
species: 840096
type: SpeciesReference

293824
stoichiometry: 1.0
species: 840105
type: SpeciesReference

292879
stoichiometry: 1.0
species: 840132
type: SpeciesReference

840418
is: SBO:0000009
constant: true
value: 9.6E-9
type: Parameter

840408
is: SBO:0000009
constant: true
value: 3.7E-4
type: Parameter

840075
is part of: IPR001023
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1400.0
in compartment: 840070
type: Species

840139
is: SBO:0000236
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

840429
is: SBO:0000009
constant: true
value: 2.0E-8
type: Parameter

293048
stoichiometry: 1.0
species: 840084
type: SpeciesReference

295041
stoichiometry: 1.0
species: 840130
type: SpeciesReference

840419
is: SBO:0000009
constant: true
value: 0.01
type: Parameter

294825
stoichiometry: 1.0
species: 840123
type: SpeciesReference

296189
stoichiometry: 2.0
species: 840079
type: SpeciesReference

293228
stoichiometry: 2.0
species: 840094
type: SpeciesReference

293132
stoichiometry: 1.0
species: 840076
type: SpeciesReference

840074
is version of: CHEBI:36080
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

840409
is: SBO:0000009
constant: false
value: 7.0
type: Parameter

296080
stoichiometry: 1.0
species: 840080
type: SpeciesReference

840416
is: SBO:0000009
constant: true
value: 1.0E-8
type: Parameter

840369
is: SBO:0000009
constant: true
value: 0.5
type: Parameter

840402
is: SBO:0000009
constant: true
value: 0.02
type: Parameter

W3 CDTF: Fri Apr 20 22:44:33 BST 2012

840343
event assignment: 296562
trigger: 296550
use values from trigger time: true
type: Event

292711
stoichiometry: 1.0
species: 840132
type: SpeciesReference

295731
stoichiometry: 1.0
species: 840075
type: SpeciesReference

296550
persistant: true
initial value: true
type: Trigger

293812
stoichiometry: 1.0
species: 840101
type: SpeciesReference

295671
stoichiometry: 1.0
species: 840132
type: SpeciesReference

296238
stoichiometry: 1.0
species: 840127
type: SpeciesReference

296466
stoichiometry: 1.0
species: 840142
type: SpeciesReference

295250
stoichiometry: 1.0
species: 840089
type: SpeciesReference

840417
is: SBO:0000009
constant: true
value: 1.0E-5
type: Parameter

295887
stoichiometry: 1.0
species: 840075
type: SpeciesReference

296370
stoichiometry: 1.0
species: 840123
type: SpeciesReference

W3 CDTF: Thu Jul 21 17:40:43 BST 2011

293012
stoichiometry: 1.0
species: 840082
type: SpeciesReference

293740
stoichiometry: 1.0
species: 840107
type: SpeciesReference

294258
stoichiometry: 1.0
species: 840125
type: SpeciesReference

840179
kinetic law: 293933
product: 293921
reactant: 293908
is version of: GO:0006412
is: SBO:0000184
fast: false
reversible: false
type: Reaction

840357
is: SBO:0000009
constant: true
value: 7.0E-7
type: Parameter

295743
stoichiometry: 1.0
species: 840117
type: SpeciesReference

295587
stoichiometry: 1.0
species: 840115
type: SpeciesReference

840414
is: SBO:0000009
constant: true
value: 2.0E-7
type: Parameter

292723
stoichiometry: 1.0
species: 840076
type: SpeciesReference

840404
is: SBO:0000009
constant: true
value: 0.05
type: Parameter

840079
is version of: IPR001404
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

296454
stoichiometry: 1.0
species: 840139
type: SpeciesReference

293519
stoichiometry: 1.0
species: 840109
type: SpeciesReference

295683
stoichiometry: 1.0
species: 840125
type: SpeciesReference

840358
is: SBO:0000009
constant: true
value: 1.0E-5
type: Parameter

292699
stoichiometry: 1.0
species: 840097
type: SpeciesReference

296165
stoichiometry: 1.0
species: 840129
type: SpeciesReference

295262
stoichiometry: 1.0
species: 840088
type: SpeciesReference

840405
is: SBO:0000009
constant: true
value: 1.0E-6
type: Parameter

295899
stoichiometry: 1.0
species: 840131
type: SpeciesReference

294849
stoichiometry: 1.0
species: 840122
type: SpeciesReference

294318
stoichiometry: 1.0
species: 840126
type: SpeciesReference

292916
stoichiometry: 1.0
species: 840134
type: SpeciesReference

292579
stoichiometry: 1.0
species: 840131
type: SpeciesReference

840386
is: SBO:0000009
constant: true
value: 2.0E-4
type: Parameter

293264
stoichiometry: 1.0
species: 840094
type: SpeciesReference

294246
stoichiometry: 1.0
species: 840132
type: SpeciesReference

295177
stoichiometry: 1.0
species: 840088
type: SpeciesReference

293204
stoichiometry: 1.0
species: 840094
type: SpeciesReference

840376
is: SBO:0000009
constant: true
value: 0.008
type: Parameter

296334
stoichiometry: 1.0
species: 840129
type: SpeciesReference

294933
stoichiometry: 1.0
species: 840127
type: SpeciesReference

840209
reversible: false
is: SBO:0000393
kinetic law: 295102
product: 295077
is version of: GO:0052064
type: Reaction
fast: false
product: 295090
reactant: 295065

840366
is: SBO:0000009
constant: true
value: 8.0E-5
type: Parameter

295851
stoichiometry: 1.0
species: 840123
type: SpeciesReference

292506
stoichiometry: 1.0
species: 840135
type: SpeciesReference

840356
is: SBO:0000009
constant: true
value: 1.0E-8
type: Parameter

292819
stoichiometry: 1.0
species: 840098
type: SpeciesReference

294330
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notes: This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE 2011; 6(7): e22038. doi:10.1371/journal.pone.0022038 , Abstract: Neurodegeneration is an age-related disorder which is characterised by the accumulation of aggregated protein and neuronal cell death. There are many different neurodegenerative diseases which are classified according to the specific proteins involved and the regions of the brain which are affected. Despite individual differences, there are common mechanisms at the sub-cellular level leading to loss of protein homeostasis. The two central systems in protein homeostasis are the chaperone system, which promotes correct protein folding, and the cellular proteolytic system, which degrades misfolded or damaged proteins. Since these systems and their interactions are very complex, we use mathematical modelling to aid understanding of the processes involved. The model developed in this study focuses on the role of Hsp70 (IPR00103) and Hsp90 (IPR001404) chaperones in preventing both protein aggregation and cell death. Simulations were performed under three different conditions: no stress; transient stress due to an increase in reactive oxygen species; and high stress due to sustained increases in reactive oxygen species. The model predicts that protein homeostasis can be maintained during short periods of stress. However, under long periods of stress, the chaperone system becomes overwhelmed and the probability of cell death pathways being activated increases. Simulations were also run in which cell death mediated by the JNK (P45983) and p38 (Q16539) pathways was inhibited. The model predicts that inhibiting either or both of these pathways may delay cell death but does not stop the aggregation process and that eventually cells die due to aggregated protein inhibiting proteasomal function. This problem can be overcome if the sequestration of aggregated protein …
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293945
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840182
is: SBO:0000526
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840166
type: Reaction
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292891
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295983
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294765
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294669
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species: 840131
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840220
is: SBO:0000180
kinetic law: 295502
product: 295478
type: Reaction
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reactant: 295466
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reversible: false
product: 295490

294053
stoichiometry: 1.0
species: 840132
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840096
has part: IPR001404
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840247
type: Reaction
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reactant: 296490
kinetic law: 296538
fast: false
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reversible: false
product: 296526

296250
stoichiometry: 1.0
species: 840129
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840110
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840090
is version of: Q9UNE7
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constant: false
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292615
stoichiometry: 1.0
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295322
stoichiometry: 1.0
species: 840092
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293313
stoichiometry: 1.0
species: 840100
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840372
is: SBO:0000009
constant: true
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type: Parameter

840205
reactant: 294933
reactant: 294921
reversible: false
fast: false
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kinetic law: 294957
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294270
stoichiometry: 1.0
species: 840134
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840219
is version of: GO:0070628
kinetic law: 295454
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fast: false
reversible: false
reactant: 295406
product: 295430
product: 295418
is: SBO:0000177
product: 295442
type: Reaction

293277
stoichiometry: 1.0
species: 840102
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293373
stoichiometry: 2.0
species: 840094
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840382
is: SBO:0000009
constant: true
value: 0.01
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840100
has part: Q00613
is: SBO:0000297
constant: false
boundary condition: false
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initial concentration: NaN
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type: Species

293470
stoichiometry: 1.0
species: 840100
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294657
stoichiometry: 1.0
species: 840111
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293957
stoichiometry: 1.0
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840130
initial amount: 0.0
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type: Species
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initial concentration: NaN

294041
stoichiometry: 1.0
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840140
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constant: false
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initial amount: 0.0
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293606
stoichiometry: 1.0
species: 840121
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294354
stoichiometry: 1.0
species: 840097
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840204
kinetic law: 294909
product: 294897
reactant: 294885
is version of: GO:0070841
is: SBO:0000177
fast: false
reversible: false
type: Reaction

840160
is: SBO:0000180
is version of: GO:0032986
kinetic law: 293216
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reactant: 293180
product: 293204
product: 293192
reversible: false
fast: false

296526
stoichiometry: 1.0
species: 840142
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840150
is: SBO:0000526
kinetic law: 292807
reactant: 292771
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product: 292795
reactant: 292783
reversible: false
fast: false
type: Reaction

840381
is: SBO:0000009
constant: true
value: 0.01
type: Parameter

295659
stoichiometry: 1.0
species: 840118
type: SpeciesReference

840122
is version of: Q16539
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100.0
in compartment: 840070
type: Species

840245
product: 296442
type: Reaction
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is version of: GO:0008219
kinetic law: 296478
reversible: false
is: SBO:0000179
reactant: 296430
product: 296454
product: 296466

840092
initial amount: 80.0
type: Species
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is: SBO:0000297
has part: IPR001404
has part: P31749
boundary condition: false
constant: false
in compartment: 840070
initial concentration: NaN
has only substance units: true

292603
stoichiometry: 1.0
species: 840074
type: SpeciesReference

293289
stoichiometry: 1.0
species: 840100
type: SpeciesReference

840207
fast: false
reactant: 294981
reversible: false
is: SBO:0000177
product: 294993
kinetic law: 295005
type: Reaction
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is version of: GO:0090261

293361
stoichiometry: 1.0
species: 840102
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840161
kinetic law: 293252
product: 293240
reactant: 293228
is version of: GO:0042803
is: SBO:0000526
fast: false
reversible: false
type: Reaction

840102
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is: SBO:0000297
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 840070
type: Species

840370
is: SBO:0000009
constant: true
value: 0.5
type: Parameter

292988
stoichiometry: 1.0
species: 840085
type: SpeciesReference

840397
is: SBO:0000009
constant: true
value: 0.03
type: Parameter

295947
stoichiometry: 1.0
species: 840076
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293325
stoichiometry: 1.0
species: 840094
type: SpeciesReference

840384
is: SBO:0000009
constant: false
value: 0.01
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295274
stoichiometry: 1.0
species: 840076
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840217
type: Reaction
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fast: false
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reactant: 295346
kinetic law: 295382
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is version of: GO:0043241

840231
is: SBO:0000177
product: 295923
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fast: false
reactant: 295887
type: Reaction
reversible: false
reactant: 295899
product: 295911
kinetic law: 295935

294017
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293618
stoichiometry: 1.0
species: 840101
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840121
is version of: IPR012233
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constant: false
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type: Species

293908
stoichiometry: 1.0
species: 840135
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294969
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species: 840129
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293993
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species: 840076
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840142
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constant: false
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initial concentration: NaN
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in compartment: 840070
type: Species

294741
stoichiometry: 1.0
species: 840117
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840244
reactant: 296370
product: 296382
type: Reaction
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reversible: false
product: 296394
kinetic law: 296418
product: 296406
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is: SBO:0000179

293969
stoichiometry: 1.0
species: 840076
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294645
stoichiometry: 1.0
species: 840131
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840101
constant: false
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has only substance units: true
in compartment: 840071
type: Species
initial concentration: NaN
boundary condition: false

840398
is: SBO:0000009
constant: true
value: 0.01
type: Parameter

296514
stoichiometry: 1.0
species: 840140
type: SpeciesReference

840216
is: SBO:0000526
is version of: GO:0006461
type: Reaction
product: 295322
reactant: 295310
kinetic law: 295334
reactant: 295298
reversible: false
fast: false

orgname: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, UK

given: Carole J
family: Proctor

orgname: EMBL-EBI

n:
  given: Vijayalakshmi
  family: Chelliah