131581
is: SBO:0000010
stoichiometry: 1.0
species: 35
type: SpeciesReference

020388
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

128866
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

129154
is: SBO:0000010
stoichiometry: 1.0
species: 36
type: SpeciesReference

130520
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

129347
is: SBO:0000010
stoichiometry: 1.0
species: 29
type: SpeciesReference

020336
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

020440
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

129494
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stoichiometry: 1.0
species: 33
type: SpeciesReference

39
is version of: P03952
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: K
type: Species

130592
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

020276
is: SBO:0000371
value: 1.0E-6
name: k
type: LocalParameter

90
kinetic law: 129711
modifier: 129699
product: 129687
reactant: 129675
fast: false
reversible: false
name: r36
type: Reaction

020460
is: SBO:0000035
value: 0.1
name: k1
type: LocalParameter

129298
is: SBO:0000010
stoichiometry: 1.0
species: 28
type: SpeciesReference

128153
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

128926
is: SBO:0000011
stoichiometry: 1.0
species: 50
type: SpeciesReference

131437
is: SBO:0000010
stoichiometry: 1.0
species: 26
type: SpeciesReference

70
kinetic law: 128758
modifier: 128746
product: 128734
reactant: 128722
fast: false
reversible: false
name: r16
type: Reaction

19
type: Species
has part: P02671
has part: P02675
initial amount: NaN
constant: false
has part: P02679
in compartment: 226
has only substance units: false
initial concentration: 8945.5
boundary condition: false
name: Fg

130532
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stoichiometry: 1.0
species: 46
type: SpeciesReference

10
is: P08709
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 226
name: VII
type: Species

131245
is: SBO:0000010
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species: 47
type: SpeciesReference

129819
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

131593
is: SBO:0000011
stoichiometry: 1.0
species: 44
type: SpeciesReference

128878
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

020452
is: SBO:0000035
value: 0.2
name: k1
type: LocalParameter

020338
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

020348
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

128818
is: SBO:0000010
stoichiometry: 1.0
species: 22
type: SpeciesReference

130447
is: SBO:0000011
stoichiometry: 1.0
species: 27
type: SpeciesReference

128914
is: SBO:0000010
stoichiometry: 1.0
species: 23
type: SpeciesReference

020278
is: SBO:0000025
value: 50.0
name: v
type: LocalParameter

020377
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

020308
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

129432
is: SBO:0000010
stoichiometry: 1.0
species: 30
type: SpeciesReference

128069
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

020431
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

020451
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

131533
is: SBO:0000010
stoichiometry: 1.0
species: 37
type: SpeciesReference

129334
is: SBO:0000010
stoichiometry: 1.0
species: 11
type: SpeciesReference

93
kinetic law: 129855
modifier: 129843
product: 129831
reactant: 129819
fast: false
reversible: false
name: r39
type: Reaction

130338
is: SBO:0000011
stoichiometry: 1.0
species: 10
type: SpeciesReference

129543
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

130410
is: SBO:0000011
stoichiometry: 1.0
species: 12
type: SpeciesReference

020444
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

131389
is: SBO:0000010
stoichiometry: 1.0
species: 14
type: SpeciesReference

12
is: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 174.3
initial amount: NaN
in compartment: 226
name: X
type: Species

16
is version of: P12259
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: Va
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129457
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species: 49
type: SpeciesReference

130712
is: SBO:0000010
stoichiometry: 1.0
species: 15
type: SpeciesReference

11
is version of: P08709
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: VIIa
type: Species

128250
is: SBO:0000010
stoichiometry: 1.0
species: 10
type: SpeciesReference

94
kinetic law: 129903
modifier: 129891
product: 129879
reactant: 129867
fast: false
reversible: false
name: r40
type: Reaction

80
kinetic law: 129226
product: 129214
reactant: 129202
reactant: 129190
fast: false
reversible: false
name: r26
type: Reaction

020443
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

15
is: P12259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.7
initial amount: NaN
in compartment: 226
name: V
type: Species

131967
is: SBO:0000011
stoichiometry: 1.0
species: 33
type: SpeciesReference

W3 CDTF: Tue Jul 05 18:07:03 BST 2011

130858
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

020453
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

29
is: P13726
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: 226
name: TF
type: Species

131317
is: SBO:0000010
stoichiometry: 1.0
species: 31
type: SpeciesReference

128578
is: SBO:0000010
stoichiometry: 1.0
species: 17
type: SpeciesReference

91
kinetic law: 129759
product: 129747
reactant: 129735
reactant: 129723
fast: false
reversible: false
name: r37
type: Reaction

81
kinetic law: 129274
product: 129262
reactant: 129250
reactant: 129238
fast: false
reversible: false
name: r27
type: Reaction

129359
is: SBO:0000011
stoichiometry: 1.0
species: 30
type: SpeciesReference

020442
is: SBO:0000035
value: 0.7
name: k1
type: LocalParameter

14
initial amount: NaN
type: Species
boundary condition: false
name: IXa_VIIIa
initial concentration: 0.0
in compartment: 226
has only substance units: false
has part: P00451
constant: false
has part: P00740

18
has part: P02675
initial concentration: 0.0
has part: P02671
name: F
type: Species
boundary condition: false
has part: P02679
initial amount: NaN
in compartment: 226
constant: false
has only substance units: false

129445
is: SBO:0000010
stoichiometry: 1.0
species: 32
type: SpeciesReference

131221
is: SBO:0000010
stoichiometry: 1.0
species: 46
type: SpeciesReference

129531
is: SBO:0000010
stoichiometry: 1.0
species: 31
type: SpeciesReference

28
is: P07204
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: 226
name: Tmod
type: Species

82
kinetic law: 129322
product: 129310
reactant: 129298
reactant: 129286
fast: false
reversible: false
name: r28
type: Reaction

128262
is: SBO:0000011
stoichiometry: 1.0
species: 11
type: SpeciesReference

92
kinetic law: 129807
modifier: 129795
product: 129783
reactant: 129771
fast: false
reversible: false
name: r38
type: Reaction

131557
is: SBO:0000010
stoichiometry: 1.0
species: 7
type: SpeciesReference

129506
is: SBO:0000011
stoichiometry: 1.0
species: 32
type: SpeciesReference

020274
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value: 50000.0
name: v
type: LocalParameter

17
is: P00734
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1394.4
initial amount: NaN
in compartment: 226
name: II
type: Species

13
is version of: P00742
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: Xa
type: Species

128165
is: SBO:0000011
stoichiometry: 1.0
species: 7
type: SpeciesReference

020455
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

129482
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

27
is: P04070
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.0
initial amount: NaN
in compartment: 226
name: PC
type: Species

020398
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

020370
is: SBO:0000371
value: 200.0
name: k
type: LocalParameter

158
kinetic law: 131787
product: 131775
fast: false
reversible: false
name: pXII
type: Reaction

020380
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

130834
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

131919
is: SBO:0000011
stoichiometry: 1.0
species: 24
type: SpeciesReference

020286
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

129214
is: SBO:0000011
stoichiometry: 1.0
species: 14
type: SpeciesReference

138
kinetic law: 131281
reactant: 131269
fast: false
reversible: false
name: dTFPI
type: Reaction

130932
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

020296
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

130568
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

131365
is: SBO:0000010
stoichiometry: 1.0
species: 36
type: SpeciesReference

020371
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

128722
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

157
kinetic law: 131763
reactant: 131751
fast: false
reversible: false
name: dXI
type: Reaction

128770
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

020316
is: SBO:0000025
value: 20000.0
name: v
type: LocalParameter

131751
is: SBO:0000010
stoichiometry: 1.0
species: 8
type: SpeciesReference

129022
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

020302
is: SBO:0000025
value: 50000.0
name: v
type: LocalParameter

128117
is: SBO:0000011
stoichiometry: 1.0
species: 6
type: SpeciesReference

130072
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

137
kinetic law: 131257
reactant: 131245
fast: false
reversible: false
name: dD
type: Reaction

128021
is: SBO:0000010
stoichiometry: 1.0
species: 2
type: SpeciesReference

020396
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

020284
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

020382
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

129202
is: SBO:0000010
stoichiometry: 1.0
species: 3
type: SpeciesReference

020298
is: SBO:0000371
value: 0.1
name: k
type: LocalParameter

020328
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

131461
is: SBO:0000010
stoichiometry: 1.0
species: 32
type: SpeciesReference

159
kinetic law: 131811
product: 131799
fast: false
reversible: false
name: pVIII
type: Reaction

129010
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

131509
is: SBO:0000010
stoichiometry: 1.0
species: 48
type: SpeciesReference

020318
is: SBO:0000371
value: 0.5
name: k
type: LocalParameter

128782
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

169
kinetic law: 132051
reactant: 132039
fast: false
reversible: false
name: dVK
type: Reaction

149
kinetic law: 131545
reactant: 131533
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reversible: false
name: dCA
type: Reaction

128830
is: SBO:0000011
stoichiometry: 1.0
species: 47
type: SpeciesReference

129190
is: SBO:0000010
stoichiometry: 1.0
species: 6
type: SpeciesReference

020300
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

130216
is: SBO:0000011
stoichiometry: 1.0
species: 35
type: SpeciesReference

130060
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

139
kinetic law: 131305
reactant: 131293
fast: false
reversible: false
name: dVIIa_TF
type: Reaction

128396
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

129238
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

131413
is: SBO:0000010
stoichiometry: 1.0
species: 28
type: SpeciesReference

020313
is: SBO:0000025
value: 9.0
name: v
type: LocalParameter

128638
is: SBO:0000011
stoichiometry: 1.0
species: 18
type: SpeciesReference

020374
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

020394
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

128033
is: SBO:0000011
stoichiometry: 1.0
species: 3
type: SpeciesReference

134
kinetic law: 131185
reactant: 131173
fast: false
reversible: false
name: dAPC
type: Reaction

129070
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

020384
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

148
kinetic law: 131521
reactant: 131509
fast: false
reversible: false
name: dTAT
type: Reaction

127997
unit: 128009
name: substance
type: SBMLUnitsDef

128444
is: SBO:0000010
stoichiometry: 1.0
species: 15
type: SpeciesReference

130132
is: SBO:0000011
stoichiometry: 1.0
species: 41
type: SpeciesReference

129627
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

132
kinetic law: 131137
reactant: 131125
fast: false
reversible: false
name: dP
type: Reaction

130204
is: SBO:0000010
stoichiometry: 1.0
species: 42
type: SpeciesReference

020326
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

020312
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

020375
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

133
kinetic law: 131161
reactant: 131149
fast: false
reversible: false
name: dPC
type: Reaction

020306
is: SBO:0000025
value: 50.0
name: v
type: LocalParameter

131341
is: SBO:0000010
stoichiometry: 1.0
species: 4
type: SpeciesReference

020299
is: SBO:0000025
value: 1.0E-9
name: v
type: LocalParameter

131775
is: SBO:0000011
stoichiometry: 1.0
species: 38
type: SpeciesReference

131823
is: SBO:0000011
stoichiometry: 1.0
species: 8
type: SpeciesReference

147
kinetic law: 131497
reactant: 131485
fast: false
reversible: false
name: dVIIa_TF_Xa_TFPI
type: Reaction

130484
is: SBO:0000011
stoichiometry: 1.0
species: 34
type: SpeciesReference

128626
is: SBO:0000010
stoichiometry: 1.0
species: 19
type: SpeciesReference

131
kinetic law: 131113
reactant: 131101
fast: false
reversible: false
name: dPg
type: Reaction

020372
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

020392
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

136
kinetic law: 131233
reactant: 131221
fast: false
reversible: false
name: dFDP
type: Reaction

131847
is: SBO:0000011
stoichiometry: 1.0
species: 15
type: SpeciesReference

020386
is: SBO:0000025
value: 0.2
name: v
type: LocalParameter

146
kinetic law: 131473
reactant: 131461
fast: false
reversible: false
name: dXa_TFPI
type: Reaction

020288
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

129639
is: SBO:0000011
stoichiometry: 1.0
species: 6
type: SpeciesReference

130120
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

128456
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stoichiometry: 1.0
species: 16
type: SpeciesReference

128734
is: SBO:0000011
stoichiometry: 1.0
species: 22
type: SpeciesReference

020324
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

130
kinetic law: 131089
reactant: 131077
fast: false
reversible: false
name: dK
type: Reaction

128105
is: SBO:0000010
stoichiometry: 1.0
species: 5
type: SpeciesReference

020314
is: SBO:0000371
value: 500.0
name: k
type: LocalParameter

130180
is: SBO:0000011
stoichiometry: 1.0
species: 53
type: SpeciesReference

130084
is: SBO:0000011
stoichiometry: 1.0
species: 51
type: SpeciesReference

131269
is: SBO:0000010
stoichiometry: 1.0
species: 33
type: SpeciesReference

135
kinetic law: 131209
reactant: 131197
fast: false
reversible: false
name: dPS
type: Reaction

020304
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

130556
is: SBO:0000010
stoichiometry: 1.0
species: 18
type: SpeciesReference

130882
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

020373
is: SBO:0000025
value: 1000.0
name: v
type: LocalParameter

130737
is: SBO:0000010
stoichiometry: 1.0
species: 16
type: SpeciesReference

145
kinetic law: 131449
reactant: 131437
fast: false
reversible: false
name: dIIa_Tmod
type: Reaction

129579
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

020287
is: SBO:0000025
value: 10.0
name: v
type: LocalParameter

129591
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

181
is: SBO:0000035
constant: true
value: 0.029
name: d_IX
type: Parameter

130168
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

174
constant: true
value: 89.6
name: IX(0)
type: Parameter

111
kinetic law: 130616
product: 130604
reactant: 130592
fast: false
reversible: false
name: dXF
type: Reaction

155
kinetic law: 131714
reactant: 131702
fast: false
reversible: false
name: eHeparinIXa
type: Reaction

020363
is: SBO:0000036
value: 0.1
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type: LocalParameter

160
kinetic law: 131835
product: 131823
fast: false
reversible: false
name: pXI
type: Reaction

131485
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stoichiometry: 1.0
species: 49
type: SpeciesReference

132039
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stoichiometry: 1.0
species: 42
type: SpeciesReference

195
constant: true
value: 10.0
name: Warfarin_Vd
type: Parameter

120
kinetic law: 130846
reactant: 130834
fast: false
reversible: false
name: dVIIIa
type: Reaction

3
is version of: P00451
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: VIIIa
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131726
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stoichiometry: 1.0
species: 51
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140
kinetic law: 131329
reactant: 131317
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reversible: false
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130628
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stoichiometry: 1.0
species: 17
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101
kinetic law: 130240
modifier: 130228
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reactant: 130204
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reversible: false
name: r47
type: Reaction

154
kinetic law: 131690
reactant: 131678
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reversible: false
name: eHeparinXa
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131871
is: SBO:0000011
stoichiometry: 1.0
species: 19
type: SpeciesReference

020322
is: SBO:0000371
value: 500.0
name: k
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110
kinetic law: 130580
product: 130568
reactant: 130556
fast: false
reversible: false
name: dF
type: Reaction

112
kinetic law: 130640
reactant: 130628
fast: false
reversible: false
name: dII
type: Reaction

180
is: SBO:0000035
constant: true
value: 0.12
name: d_VII
type: Parameter

129975
is: SBO:0000011
stoichiometry: 1.0
species: 9
type: SpeciesReference

175
constant: true
value: 174.3
name: X(0)
type: Parameter

020410
is: SBO:0000035
value: 0.05
name: k1
type: LocalParameter

156
kinetic law: 131739
reactant: 131726
fast: false
reversible: false
name: eHeparinIIa
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131125
is: SBO:0000010
stoichiometry: 1.0
species: 21
type: SpeciesReference

020362
is: SBO:0000036
value: 0.5
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161
kinetic law: 131859
product: 131847
fast: false
reversible: false
name: pV
type: Reaction

128590
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stoichiometry: 1.0
species: 1
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122
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51
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notes: This model is from the article: A comprehensive model for the humoral coagulation network in humans. Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeutics Volume 86, Issue 3, 10 June 2009, EPub 19516255 , Abstract: Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.
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constant: false
boundary condition: false
has only substance units: false
initial concentration: 450.0
initial amount: NaN
in compartment: 226
name: Pk
type: Species

96
kinetic law: 130000
modifier: 129988
product: 129975
reactant: 129963
fast: false
reversible: false
name: r42
type: Reaction

117
kinetic law: 130773
reactant: 130761
fast: false
reversible: false
name: dVII
type: Reaction

130652
is: SBO:0000010
stoichiometry: 1.0
species: 1
type: SpeciesReference

217
constant: true
value: 2.5
name: TFPI(0)
type: Parameter

222
is: SBO:0000036
constant: true
value: 0.85
name: c45
type: Parameter

020369
is: SBO:0000025
value: 900.0
name: v
type: LocalParameter

020359
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

203
is: SBO:0000035
constant: true
value: 0.032
name: d_Fg
type: Parameter

86
kinetic law: 129518
product: 129506
reactant: 129494
reactant: 129482
fast: false
reversible: false
name: r32
type: Reaction

020425
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

020419
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

128214
is: SBO:0000011
stoichiometry: 1.0
species: 7
type: SpeciesReference

020340
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

8
is: P03951
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.6
initial amount: NaN
in compartment: 226
name: XI
type: Species

36
constant: false
name: Va_Xa
type: Species
initial amount: NaN
initial concentration: 0.0
has part: P12259
in compartment: 226
has part: P00742
has only substance units: false
boundary condition: false

65
kinetic law: 128518
modifier: 128505
reactant: 128493
fast: false
reversible: false
name: r11
type: Reaction

129915
is: SBO:0000010
stoichiometry: 1.0
species: 38
type: SpeciesReference

020330
is: SBO:0000371
value: 10.0
name: k
type: LocalParameter

75
kinetic law: 128998
modifier: 128986
product: 128974
reactant: 128962
fast: false
reversible: false
name: r21
type: Reaction

020281
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

129118
is: SBO:0000011
stoichiometry: 1.0
species: 25
type: SpeciesReference

020446
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

26
has only substance units: false
boundary condition: false
has part: P00734
constant: false
has part: P07204
initial amount: NaN
name: IIa_Tmod
type: Species
initial concentration: 0.0
in compartment: 226

131653
is: SBO:0000010
stoichiometry: 1.0
species: 40
type: SpeciesReference

46
has part: P02675
has part: P02671
in compartment: 226
has part: P02679
boundary condition: false
initial concentration: 0.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: FDP

118
kinetic law: 130797
reactant: 130785
fast: false
reversible: false
name: dVIIa
type: Reaction

95
kinetic law: 129951
modifier: 129939
product: 129927
reactant: 129915
fast: false
reversible: false
name: r41
type: Reaction

223
is: SBO:0000036
constant: true
value: 0.85
name: c46
type: Parameter

216
constant: true
value: 50.0
name: Tmod(0)
type: Parameter

020358
is: SBO:0000036
value: 0.01
name: c
type: LocalParameter

020368
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

85
kinetic law: 129470
product: 129457
reactant: 129445
reactant: 129432
fast: false
reversible: false
name: r31
type: Reaction

56
kinetic law: 128093
modifier: 128081
reactant: 128069
fast: false
reversible: false
name: r2
type: Reaction

202
is: SBO:0000035
constant: true
value: 0.043
name: d_V
type: Parameter

129723
is: SBO:0000010
stoichiometry: 1.0
species: 25
type: SpeciesReference

74
kinetic law: 128950
modifier: 128938
product: 128926
reactant: 128914
fast: false
reversible: false
name: r20
type: Reaction

105
kinetic law: 130398
modifier: 130386
product: 130374
fast: false
reversible: false
name: pIX_VKH2
type: Reaction

129675
is: SBO:0000010
stoichiometry: 1.0
species: 31
type: SpeciesReference

131053
is: SBO:0000010
stoichiometry: 1.0
species: 45
type: SpeciesReference

129310
is: SBO:0000011
stoichiometry: 1.0
species: 26
type: SpeciesReference

129262
is: SBO:0000011
stoichiometry: 1.0
species: 36
type: SpeciesReference

60
kinetic law: 128286
modifier: 128274
product: 128262
reactant: 128250
fast: false
reversible: false
name: r6
type: Reaction

88
kinetic law: 129615
modifier: 129603
product: 129591
reactant: 129579
fast: false
reversible: false
name: r34
type: Reaction

020433
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

128359
is: SBO:0000011
stoichiometry: 1.0
species: 13
type: SpeciesReference

33
is: P10646
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 226
name: TFPI
type: Species

020367
is: SBO:0000025
value: 70.0
name: v
type: LocalParameter

219
constant: true
value: 0.140845070422535
name: R1
type: Parameter

209
constant: true
value: 375.0
name: XII(0)
type: Parameter

131678
is: SBO:0000010
stoichiometry: 1.0
species: 41
type: SpeciesReference

47
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: D
type: Species

185
constant: true
value: 24.0
name: VitaminK_Vc
type: Parameter

020423
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

170
constant: true
value: 1.0
name: I_max
type: Parameter

131101
is: SBO:0000010
stoichiometry: 1.0
species: 24
type: SpeciesReference

73
kinetic law: 128902
modifier: 128890
product: 128878
reactant: 128866
fast: false
reversible: false
name: r19
type: Reaction

220
constant: true
value: 1.0
name: R2
type: Parameter

020332
is: SBO:0000371
value: 100.0
name: k
type: LocalParameter

34
is: P07225
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: 226
name: PS
type: Species

106
kinetic law: 130435
modifier: 130422
product: 130410
fast: false
reversible: false
name: pX_VKH2
type: Reaction

020346
is: SBO:0000371
value: 10000.0
name: k
type: LocalParameter

199
is: SBO:0000035
constant: true
value: 0.012
name: d_XII
type: Parameter

128974
is: SBO:0000011
stoichiometry: 1.0
species: 21
type: SpeciesReference

198
constant: false
value: 0.0
name: Integral_Fibrin
type: Parameter

128009
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

87
kinetic law: 129567
modifier: 129555
product: 129543
reactant: 129531
fast: false
reversible: false
name: r33
type: Reaction

130024
is: SBO:0000011
stoichiometry: 1.0
species: 39
type: SpeciesReference

020366
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

218
constant: true
value: 450.0
name: Pk(0)
type: Parameter

208
is: SBO:0000035
constant: true
value: 0.05
name: d_Pk
type: Parameter

221
is: SBO:0000036
constant: true
value: 0.119718309859155
name: c44
type: Parameter

20
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: DP
type: Species

171
constant: true
value: 0.34
name: IC50
type: Parameter

020352
is: SBO:0000025
value: 7.0
name: v
type: LocalParameter

184
is: SBO:0000035
constant: true
value: 0.0165
name: d_PS
type: Parameter

48
has part: P00734
in compartment: 226
initial amount: NaN
type: Species
boundary condition: false
name: TAT
initial concentration: 0.0
has only substance units: false
constant: false
has part: P01008

128298
is: SBO:0000010
stoichiometry: 1.0
species: 12
type: SpeciesReference

72
kinetic law: 128854
modifier: 128842
product: 128830
reactant: 128818
fast: false
reversible: false
name: r18
type: Reaction

188
constant: true
value: 0.228
name: d_VKO
type: Parameter

129250
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

62
kinetic law: 128384
modifier: 128372
product: 128359
reactant: 128347
fast: false
reversible: false
name: r8
type: Reaction

020345
is: SBO:0000025
value: 5.0
name: v
type: LocalParameter

020449
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

107
kinetic law: 130472
modifier: 130459
product: 130447
fast: false
reversible: false
name: pPC_VKH2
type: Reaction

31
has part: P13726
name: VII_TF
boundary condition: false
initial amount: NaN
has part: P08709
in compartment: 226
has only substance units: false
initial concentration: 0.0
constant: false
type: Species

232
event assignment: 132075
trigger: 132063
use values from trigger time: true
name: clottingTime event
type: Event

020435
is: SBO:0000035
value: 20.4
name: k1
type: LocalParameter

59
kinetic law: 128238
modifier: 128226
product: 128214
reactant: 128202
fast: false
reversible: false
name: r5
type: Reaction

197
constant: true
value: 0.02
name: Warfarin_ke
type: Parameter

130108
is: SBO:0000010
stoichiometry: 1.0
species: 13
type: SpeciesReference

128686
is: SBO:0000011
stoichiometry: 1.0
species: 46
type: SpeciesReference

131029
is: SBO:0000010
stoichiometry: 1.0
species: 50
type: SpeciesReference

020421
is: SBO:0000035
value: 20.0
name: k1
type: LocalParameter

187
is: SBO:0000035
constant: true
value: 0.228
name: d_VKH2
type: Parameter

21
is version of: P00747
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 226
name: P
type: Species

49
type: Species
has part: P00742
has part: P13726
constant: false
has part: P10646
has part: P08709
initial concentration: 0.0
name: VIIa_TF_Xa_TFPI
initial amount: NaN
in compartment: 226
has only substance units: false
boundary condition: false

020355
is: SBO:0000025
value: 2.0
name: v
type: LocalParameter

207
is: SBO:0000035
constant: true
value: 20.0
name: d_TFPI
type: Parameter

108
kinetic law: 130508
modifier: 130496
product: 130484
fast: false
reversible: false
name: pPS_VKH2
type: Reaction

71
kinetic law: 128806
modifier: 128794
product: 128782
reactant: 128770
fast: false
reversible: false
name: r17
type: Reaction

020334
is: SBO:0000025
value: 1.0
name: v
type: LocalParameter

020344
is: SBO:0000371
value: 5000.0
name: k
type: LocalParameter

89
kinetic law: 129663
modifier: 129651
product: 129639
reactant: 129627
fast: false
reversible: false
name: r35
type: Reaction

61
kinetic law: 128335
modifier: 128323
product: 128310
reactant: 128298
fast: false
reversible: false
name: r7
type: Reaction

233
event assignment: 132099
trigger: 132087
use values from trigger time: true
name: dilution event
type: Event

206
is: SBO:0000035
constant: true
value: 0.05
name: d_Tmod
type: Parameter

32
constant: false
type: Species
boundary condition: false
has part: P10646
name: Xa_TFPI
initial amount: NaN
initial concentration: 0.0
has part: P00742
in compartment: 226
has only substance units: false

196
constant: true
value: 0.2
name: Warfarin_CL
type: Parameter

020364
is: SBO:0000036
value: 0.5
name: c
type: LocalParameter

186
constant: true
value: 0.0228
name: d_VK2
type: Parameter

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

130012
is: SBO:0000010
stoichiometry: 1.0
species: 45
type: SpeciesReference

020354
is: SBO:0000371
value: 1.0
name: k
type: LocalParameter

99
kinetic law: 130144
product: 130132
reactant: 130120
reactant: 130108
fast: false
reversible: false
name: r45
type: Reaction

22
initial concentration: 0.0
has only substance units: false
in compartment: 226
constant: false
has part: P02675
name: XF
boundary condition: false
type: Species
has part: P02671
initial amount: NaN
has part: P02679

W3 CDTF: Fri Apr 20 22:45:59 BST 2012