058961
stoichiometry: 1.0
species: 295159
type: SpeciesReference

058803
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scale: 0
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kind: DIMENSIONLESS
type: SBMLUnit

295167
kinetic law: 058974
reactant: 058961
is version of: GO:0008219
is: SBO:0000179
fast: false
reversible: true
name: cell death 2
type: Reaction

058986
persistant: true
initial value: true
type: Trigger

BIOMD0000000337
units def: 058790
time units: 058790
notes: This model is from the article: Cooperation and Competition in the Evolution of ATP-Producing Pathways Thomas Pfeiffer, Stefan Schuster, Sebastian Bonhoeffer Science 2001 Apr; Volume:292 (Issue:5516); Page info:504-7 11283355 , Abstract: Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production. This trade-off may result in an evolutionary dilemma, because cells with a higher rate but lower yield of ATP production may gain a selective advantage when competing for shared energy resources. Using an analysis of model simulations and biochemical observations, we show that ATP production with a low rate and high yield can be viewed as a form of cooperative resource use and may evolve in spatially structured environments. Furthermore, we argue that the high ATP yield of respiration may have facilitated the evolutionary transition from unicellular to undifferentiated multicellular organisms. Note: This model reproduces the competition and invasion described in Supplemental Figure 2.
species: 295159
reaction: 295164
units def: 058815
is: MODEL1105120000
curated: true
length unit: length
is version of: GO:0006754
reaction: 295167
species: 295157
reaction: 295162
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
is described by: http://identifiers.org/pubmed/11283355
reaction: 295161
area units: area
event: 295173
modified:
  W3 CDTF: Fri Apr 20 22:52:36 BST 2012
compartment: 295154
name: Pfeiffer2001_ATP-ProducingPathways_CooperationCompetition
units def: 058766
species: 295156
volume units: 058815
parameter: 295178
type: SBMLModel
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
created:
  W3 CDTF: Thu May 12 01:00:00 BST 2011
occurs in: http://identifiers.org/taxonomy/131567
substance units: 058766
is version of: GO:0071318
parameter: 295180
reaction: 295165

295157
is version of: GO:0005623
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: 295154
name: N1
type: Species

295159
is version of: GO:0005623
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 295154
name: N2
type: Species

295173
event assignment: 058998
trigger: 058986
use values from trigger time: true
type: Event

058912
stoichiometry: 1.0
species: 295159
type: SpeciesReference

295165
kinetic law: 058949
reactant: 058937
is version of: GO:0008219
is: SBO:0000179
fast: false
reversible: true
name: cell death 1
type: Reaction

058778
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

058900
stoichiometry: 1.0
species: 295156
type: SpeciesReference

295161
kinetic law: 058852
product: 058839
is version of: GO:0006754
is: SBO:0000393
fast: false
reversible: true
name: resource production
type: Reaction

058937
stoichiometry: 1.0
species: 295157
type: SpeciesReference

295178
constant: true
units: dimensionless
value: 10.0
type: Parameter

295154
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

058839
stoichiometry: 1.0
species: 295156
type: SpeciesReference

058864
stoichiometry: 1.0
species: 295156
type: SpeciesReference

295156
is version of: PATO:0001021
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 295154
name: S
type: Species

058876
stoichiometry: 10.0
species: 295157
type: SpeciesReference

295162
kinetic law: 058888
product: 058876
reactant: 058864
is version of: GO:0016049
is: SBO:0000394
fast: false
reversible: true
name: resource consumption and cell growth 1
type: Reaction

058827
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

295164
kinetic law: 058925
product: 058912
reactant: 058900
is version of: GO:0016049
is: SBO:0000394
fast: false
reversible: true
name: resource consumption and cell growth 2
type: Reaction

295180
constant: true
units: dimensionless
value: 1.0
type: Parameter