metaid_0000129
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIa_f
type: Species

metaid_0000159
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IXa_VIIIa_X_l
type: Species

978849
stoichiometry: 1.0
species: metaid_0000159
type: SpeciesReference

metaid_0000139
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_f
type: Species

metaid_0000052
constant: true
value: 15.2
type: Parameter

978897
stoichiometry: 1.0
species: metaid_0000157
type: SpeciesReference

metaid_0000119
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: metaid_0000114
name: V_f
type: Species

977915
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

metaid_0000198
kinetic law: 978001
product: 977989
reactant: 977977
reactant: 977965
fast: false
reversible: false
name: Factor X lipid binding
type: Reaction

metaid_0000032
constant: true
value: 0.2
type: Parameter

metaid_0000245
kinetic law: 980254
product: 980241
reactant: 980229
reactant: 980217
fast: false
reversible: false
type: Reaction

979838
stoichiometry: 1.0
species: metaid_0000146
type: SpeciesReference

metaid_0000109
constant: true
value: 0.1
type: Parameter

977867
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

978472
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000179
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_AT_f
type: Species

metaid_0000128
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIII_l
type: Species

metaid_0000158
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_Va_l
type: Species

978159
stoichiometry: 1.0
species: metaid_0000143
type: SpeciesReference

977965
stoichiometry: 1.0
species: metaid_0000135
type: SpeciesReference

978183
stoichiometry: 1.0
species: metaid_0000144
type: SpeciesReference

metaid_0000051
constant: true
value: 44.8
type: Parameter

977467
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000138
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_l
type: Species

metaid_0000118
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_l
type: Species

metaid_0000050
constant: true
value: 0.05
type: Parameter

metaid_0000246
kinetic law: 980302
product: 980290
product: 980278
reactant: 980266
fast: false
reversible: false
type: Reaction

metaid_0000031
constant: true
value: 0.05
type: Parameter

metaid_0000199
kinetic law: 978051
product: 978039
reactant: 978026
reactant: 978013
fast: false
reversible: false
name: Factor Xa lipid binding
type: Reaction

979934
stoichiometry: 1.0
species: metaid_0000175
type: SpeciesReference

metaid_0000108
constant: true
value: 6.83E-6
type: Parameter

metaid_0000178
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IXa_AT_f
type: Species

979778
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

977673
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000040
constant: true
value: 0.005
type: Parameter

metaid_0000127
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: metaid_0000114
name: VIII_f
type: Species

metaid_0000030
constant: true
value: 3.5
type: Parameter

979947
stoichiometry: 1.0
species: metaid_0000176
type: SpeciesReference

979115
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

977879
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

979826
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

metaid_0000107
constant: true
value: 3.6
type: Parameter

978885
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

977927
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

980278
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000243
kinetic law: 980156
product: 980144
reactant: 980132
reactant: 980120
fast: false
reversible: false
type: Reaction

metaid_0000020
constant: true
value: 0.335
type: Parameter

metaid_0000126
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIa_l
type: Species

977479
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

978995
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000106
constant: true
value: 6.4
type: Parameter

metaid_0000244
kinetic law: 980204
product: 980192
product: 980180
reactant: 980168
fast: false
reversible: false
type: Reaction

metaid_0000056
constant: true
value: 1.0
type: Parameter

metaid_0000193
kinetic law: 977758
product: 977746
reactant: 977734
reactant: 977721
fast: false
reversible: false
name: Factor VIIa lipid binding
type: Reaction

metaid_0000069
constant: true
value: 0.1
type: Parameter

978304
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000042
constant: true
value: 0.005
type: Parameter

979332
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

979091
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

metaid_0000169
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: XIa_l
type: Species

metaid_0000155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_Xa_l
type: Species

metaid_0000105
constant: true
value: 0.1
type: Parameter

metaid_0000241
kinetic law: 980059
product: 980047
reactant: 980035
reactant: 980020
fast: false
reversible: false
type: Reaction

980483
stoichiometry: 1.0
species: metaid_0000186
type: SpeciesReference

metaid_0000251
kinetic law: 980543
product: 980531
reactant: 980519
reactant: 980507
fast: false
reversible: false
type: Reaction

metaid_0000194
kinetic law: 977807
product: 977795
reactant: 977783
reactant: 977770
fast: false
reversible: false
name: Factor VIII lipid binding
type: Reaction

metaid_0000115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1400.0
initial amount: NaN
in compartment: metaid_0000114
name: II_f
type: Species

980132
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

980192
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000168
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: XI_IIa_l
type: Species

metaid_0000055
constant: true
value: 1.0
type: Parameter

980315
stoichiometry: 1.0
species: metaid_0000183
type: SpeciesReference

978983
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000041
constant: true
value: 0.005
type: Parameter

metaid_0000154
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_X_l
type: Species

metaid_0000242
kinetic law: 980108
product: 980095
reactant: 980083
reactant: 980071
fast: false
reversible: false
type: Reaction

metaid_0000104
constant: true
value: 0.5
type: Parameter

978207
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

metaid_0000195
kinetic law: 977855
product: 977843
reactant: 977831
reactant: 977819
fast: false
reversible: false
name: Factor VIIIa lipid binding
type: Reaction

978702
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

978364
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

metaid_0000252
kinetic law: 980591
product: 980579
reactant: 980567
reactant: 980555
fast: false
reversible: false
type: Reaction

metaid_0000114
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

977989
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000054
constant: true
value: 0.2
type: Parameter

978460
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

978970
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

metaid_0000167
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.0
initial amount: NaN
in compartment: metaid_0000114
name: XI_f
type: Species

979320
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000157
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IXa_VIIIa_l
type: Species

metaid_0000044
constant: true
value: 2.09
type: Parameter

980471
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

980120
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000103
constant: true
value: 1.0
type: Parameter

metaid_0000117
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_f
type: Species

978509
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000253
kinetic law: 980639
product: 980627
product: 980615
reactant: 980603
fast: false
reversible: false
type: Reaction

metaid_0000196
kinetic law: 977903
product: 977891
reactant: 977879
reactant: 977867
fast: false
reversible: false
name: Factor IX lipid binding
type: Reaction

979633
stoichiometry: 1.0
species: metaid_0000168
type: SpeciesReference

metaid_0000053
constant: true
value: 0.1
type: Parameter

979922
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000166
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_Va_mIIa_l
type: Species

metaid_0000156
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VII_Xa_l
type: Species

979984
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

metaid_0000043
constant: true
value: 0.01
type: Parameter

979693
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

978376
stoichiometry: 1.0
species: metaid_0000151
type: SpeciesReference

metaid_0000240
kinetic law: 980008
product: 979996
reactant: 979984
reactant: 979971
fast: false
reversible: false
type: Reaction

977977
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000254
unit: 977467
name: nano mole
type: SBMLUnitsDef

metaid_0000102
constant: true
value: 0.9
type: Parameter

metaid_0000116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: II_l
type: Species

978219
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000197
kinetic law: 977953
product: 977940
reactant: 977927
reactant: 977915
fast: false
reversible: false
name: Factor IXa lipid binding
type: Reaction

metaid_0000085
constant: true
value: 1.6
type: Parameter

metaid_0000026
constant: true
value: 1.9
type: Parameter

metaid_0000006
constant: true
value: 1.0
type: Parameter

metaid_0000185
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_TM_PC_l
type: Species

metaid_0000099
constant: true
value: 1.035
type: Parameter

980411
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

metaid_0000151
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VII_l
type: Species

metaid_0000079
constant: true
value: 44.8
type: Parameter

979996
stoichiometry: 1.0
species: metaid_0000178
type: SpeciesReference

metaid_0000046
constant: true
value: 0.1
type: Parameter

979441
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

979681
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

979705
stoichiometry: 1.0
species: metaid_0000171
type: SpeciesReference

977734
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000170
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_PS_l
type: Species

metaid_0000165
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_Va_II_l
type: Species

metaid_0000065
constant: true
value: 0.023
type: Parameter

978026
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

979597
stoichiometry: 1.0
species: metaid_0000167
type: SpeciesReference

metaid_0000086
constant: true
value: 0.4
type: Parameter

metaid_0000005
constant: true
value: 100.0
type: Parameter

metaid_0000184
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_TM_l
type: Species

978727
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

metaid_0000025
constant: true
value: 0.01
type: Parameter

metaid_0000039
constant: true
value: 0.5
type: Parameter

metaid_0000150
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_l
type: Species

metaid_0000059
constant: true
value: 8.3
type: Parameter

metaid_0000045
constant: true
value: 0.34
type: Parameter

metaid_0000066
constant: true
value: 0.1
type: Parameter

metaid_0000164
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIII_IIa_l
type: Species

980083
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

978400
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

metaid_0000183
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000114
name: TM_l
type: Species

978352
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000087
constant: true
value: 0.1
type: Parameter

980423
stoichiometry: 1.0
species: metaid_0000140
type: SpeciesReference

metaid_0000028
constant: true
value: 3.3
type: Parameter

metaid_0000008
constant: true
value: 0.475
type: Parameter

978800
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000097
constant: true
value: 0.1
type: Parameter

metaid_0000038
constant: true
value: 11.5
type: Parameter

977540
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

978063
stoichiometry: 1.0
species: metaid_0000139
type: SpeciesReference

metaid_0000173
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3400.0
initial amount: NaN
in compartment: metaid_0000114
name: AT_f
type: Species

metaid_0000230
kinetic law: 979525
product: 979513
reactant: 979501
reactant: 979489
fast: false
reversible: false
type: Reaction

978013
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000210
kinetic law: 978569
product: 978557
reactant: 978545
fast: false
reversible: false
name: Factor X activation
type: Reaction

978752
stoichiometry: 1.0
species: metaid_0000157
type: SpeciesReference

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

metaid_0000077
constant: true
value: 15.0
type: Parameter

metaid_0000153
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_IXa_l
type: Species

979971
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

980180
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000163
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_IIa_l
type: Species

metaid_0000067
constant: true
value: 6.94
type: Parameter

977746
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000058
constant: true
value: 10.7
type: Parameter

metaid_0000048
constant: true
value: 1.5
type: Parameter

metaid_0000182
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIII_mIIa_l
type: Species

metaid_0000088
constant: true
value: 1.6
type: Parameter

metaid_0000007
constant: true
value: 0.05
type: Parameter

metaid_0000027
constant: true
value: 0.029
type: Parameter

metaid_0000250
kinetic law: 980495
product: 980483
reactant: 980471
reactant: 980459
fast: false
reversible: false
type: Reaction

979585
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000037
constant: true
value: 0.05
type: Parameter

metaid_0000098
constant: true
value: 6.94
type: Parameter

metaid_0000172
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_f
type: Species

metaid_0000171
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_PS_VIIIa_l
type: Species

metaid_0000047
constant: true
value: 32.5
type: Parameter

980095
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

metaid_0000078
constant: true
value: 0.05
type: Parameter

metaid_0000152
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_IX_l
type: Species

978412
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000162
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_f
type: Species

metaid_0000068
constant: true
value: 0.23
type: Parameter

metaid_0000181
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_mIIa_l
type: Species

metaid_0000057
constant: true
value: 0.1
type: Parameter

979561
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

979729
stoichiometry: 1.0
species: metaid_0000171
type: SpeciesReference

metaid_0000175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_l
type: Species

980507
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

metaid_0000232
kinetic law: 979621
product: 979609
reactant: 979597
reactant: 979585
fast: false
reversible: false
type: Reaction

metaid_0000022
constant: true
value: 0.115
type: Parameter

979465
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000036
constant: true
value: 0.17
type: Parameter

978788
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_Xa_l
type: Species

metaid_0000222
kinetic law: 979152
product: 979139
reactant: 979127
reactant: 979115
fast: false
reversible: false
type: Reaction

metaid_0000189
kinetic law: 977564
product: 977552
reactant: 977540
reactant: 977528
fast: false
reversible: false
name: Factor mIIa lipid binding
type: Reaction

metaid_0000060
constant: true
value: 0.1
type: Parameter

metaid_0000089
constant: true
value: 0.4
type: Parameter

978836
stoichiometry: 1.0
species: metaid_0000157
type: SpeciesReference

metaid_0000161
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIII_Xa_l
type: Species

978075
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000075
constant: true
value: 66.0
type: Parameter

980435
stoichiometry: 1.0
species: metaid_0000184
type: SpeciesReference

metaid_0000174
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_AT_f
type: Species

metaid_0000021
constant: true
value: 0.05
type: Parameter

metaid_0000231
kinetic law: 979573
product: 979561
product: 979549
reactant: 979537
fast: false
reversible: false
type: Reaction

metaid_0000009
constant: true
value: 0.05
type: Parameter

metaid_0000035
constant: true
value: 0.057
type: Parameter

metaid_0000188
kinetic law: 977516
product: 977503
reactant: 977491
reactant: 977479
fast: false
reversible: false
name: Factor II lipid binding
type: Reaction

metaid_0000221
kinetic law: 979103
product: 979091
product: 979079
reactant: 979067
fast: false
reversible: false
name: Factor VIII activation
type: Reaction

978424
stoichiometry: 1.0
species: metaid_0000152
type: SpeciesReference

979127
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000061
constant: true
value: 1.0
type: Parameter

metaid_0000049
constant: true
value: 1.0
type: Parameter

977940
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000062
constant: true
value: 0.043
type: Parameter

978629
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000076
constant: true
value: 13.0
type: Parameter

metaid_0000177
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_PS_Va_l
type: Species

metaid_0000024
constant: true
value: 0.115
type: Parameter

978776
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000234
kinetic law: 979717
product: 979705
reactant: 979693
reactant: 979681
fast: false
reversible: false
type: Reaction

metaid_0000072
constant: true
value: 0.1
type: Parameter

980519
stoichiometry: 1.0
species: metaid_0000140
type: SpeciesReference

977819
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

979501
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000220
kinetic law: 979055
product: 979043
reactant: 979031
reactant: 979019
fast: false
reversible: false
name: Xa_VIII binding
type: Reaction

979453
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000187
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: XIa_IX_l
type: Species

980459
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

metaid_0000034
constant: true
value: 0.335
type: Parameter

978171
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

978496
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000063
constant: true
value: 0.1
type: Parameter

978824
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000073
constant: true
value: 100.0
type: Parameter

978087
stoichiometry: 1.0
species: metaid_0000140
type: SpeciesReference

metaid_0000233
kinetic law: 979669
product: 979657
product: 979645
reactant: 979633
fast: false
reversible: false
type: Reaction

metaid_0000023
constant: true
value: 0.05
type: Parameter

980071
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

metaid_0000176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_TF_VIIa_l
type: Species

979139
stoichiometry: 1.0
species: metaid_0000163
type: SpeciesReference

metaid_0000186
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_AT_l
type: Species

978922
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000033
constant: true
value: 0.05
type: Parameter

metaid_0000064
constant: true
value: 2.1
type: Parameter

metaid_0000074
constant: true
value: 0.1
type: Parameter

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

980020
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

979417
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

metaid_0000091
constant: true
value: 3.3E-4
type: Parameter

metaid_0000203
kinetic law: 978244
product: 978231
reactant: 978219
reactant: 978207
fast: false
reversible: false
name: Factor Vai lipid binding
type: Reaction

979369
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000213
kinetic law: 978714
product: 978702
product: 978689
reactant: 978677
fast: false
reversible: false
name: TF_VII activation
type: Reaction

metaid_0000223
kinetic law: 979200
product: 979188
product: 979176
reactant: 979164
fast: false
reversible: false
type: Reaction

978123
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

978946
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

metaid_0000071
constant: true
value: 0.9
type: Parameter

metaid_0000090
constant: true
value: 0.016
type: Parameter

979850
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

977491
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000204
kinetic law: 978292
product: 978280
reactant: 978268
reactant: 978256
fast: false
reversible: false
name: PC lipid binding
type: Reaction

980363
stoichiometry: 1.0
species: metaid_0000148
type: SpeciesReference

979489
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000224
kinetic law: 979248
product: 979236
reactant: 979224
reactant: 979212
fast: false
reversible: false
type: Reaction

metaid_0000010
constant: true
value: 0.145
type: Parameter

metaid_0000214
kinetic law: 978764
product: 978752
reactant: 978740
reactant: 978727
fast: false
reversible: false
name: VIIIa_IXa binding
type: Reaction

977636
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000070
constant: true
value: 13.8
type: Parameter

979405
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

metaid_0000205
kinetic law: 978340
product: 978328
reactant: 978316
reactant: 978304
fast: false
reversible: false
name: TF_VIIa binding
type: Reaction

977721
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

978545
stoichiometry: 1.0
species: metaid_0000154
type: SpeciesReference

978448
stoichiometry: 1.0
species: metaid_0000152
type: SpeciesReference

metaid_0000225
kinetic law: 979296
product: 979284
product: 979272
reactant: 979260
fast: false
reversible: false
type: Reaction

978135
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

978934
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000211
kinetic law: 978617
product: 978605
product: 978593
reactant: 978581
fast: false
reversible: false
name: Factor Xa release
type: Reaction

978280
stoichiometry: 1.0
species: metaid_0000148
type: SpeciesReference

980603
stoichiometry: 1.0
species: metaid_0000187
type: SpeciesReference

metaid_0000011
constant: true
value: 0.057
type: Parameter

980555
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

978039
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

977528
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

978740
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000206
kinetic law: 978388
product: 978376
reactant: 978364
reactant: 978352
fast: false
reversible: false
name: TF_VII binding
type: Reaction

979067
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000212
kinetic law: 978665
product: 978653
reactant: 978641
reactant: 978629
fast: false
reversible: false
name: Xa_TF_VII binding
type: Reaction

metaid_0000226
kinetic law: 979345
product: 979332
reactant: 979320
reactant: 979308
fast: false
reversible: false
type: Reaction

977624
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

979513
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

977552
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000012
constant: true
value: 0.17
type: Parameter

980375
stoichiometry: 1.0
species: metaid_0000184
type: SpeciesReference

metaid_0000081
constant: true
value: 0.1
type: Parameter

980615
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

980567
stoichiometry: 1.0
species: metaid_0000169
type: SpeciesReference

979031
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

980327
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000096
constant: true
value: 6.83E-5
type: Parameter

metaid_0000217
kinetic law: 978910
product: 978897
product: 978885
reactant: 978873
fast: false
reversible: false
name: Factor X activation
type: Reaction

metaid_0000013
constant: true
value: 0.05
type: Parameter

978557
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

978641
stoichiometry: 1.0
species: metaid_0000151
type: SpeciesReference

metaid_0000003
constant: true
value: 0.0043
type: Parameter

979790
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

metaid_0000017
constant: true
value: 0.05
type: Parameter

metaid_0000227
kinetic law: 979393
product: 979381
reactant: 979369
reactant: 979357
fast: false
reversible: false
type: Reaction

metaid_0000080
constant: true
value: 15.2
type: Parameter

980387
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

979549
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VII_Xa_l
type: Species

977588
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000200
kinetic law: 978099
product: 978087
reactant: 978075
reactant: 978063
fast: false
reversible: false
name: APC lipid binding
type: Reaction

metaid_0000094
constant: true
value: 4.9E-7
type: Parameter

metaid_0000095
constant: true
value: 2.3E-6
type: Parameter

metaid_0000004
constant: false
boundary condition: false
has only substance units: false
initial concentration: 849079.0
initial amount: NaN
in compartment: metaid_0000114
name: LIPID
type: Species

980290
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

metaid_0000218
kinetic law: 978958
product: 978946
reactant: 978934
reactant: 978922
fast: false
reversible: false
name: V_Xa binding
type: Reaction

metaid_0000014
constant: true
value: 0.66
type: Parameter

metaid_0000228
kinetic law: 979429
product: 979417
reactant: 979405
fast: false
reversible: false
type: Reaction

979308
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

980035
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000018
constant: true
value: 0.1
type: Parameter

978111
stoichiometry: 1.0
species: metaid_0000141
type: SpeciesReference

979043
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000083
constant: true
value: 1.43
type: Parameter

978605
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000093
constant: true
value: 0.0011
type: Parameter

980627
stoichiometry: 1.0
species: metaid_0000169
type: SpeciesReference

metaid_0000140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_l
type: Species

metaid_0000201
kinetic law: 978147
product: 978135
reactant: 978123
reactant: 978111
fast: false
reversible: false
name: PS lipid binding
type: Reaction

980579
stoichiometry: 1.0
species: metaid_0000187
type: SpeciesReference

979357
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000029
constant: true
value: 0.05
type: Parameter

metaid_0000215
kinetic law: 978812
product: 978800
reactant: 978788
reactant: 978776
fast: false
reversible: false
name: Va_Xa binding
type: Reaction

978653
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

979381
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

980339
stoichiometry: 1.0
species: metaid_0000184
type: SpeciesReference

metaid_0000084
constant: true
value: 0.1
type: Parameter

metaid_0000101
constant: true
value: 13.8
type: Parameter

metaid_0000229
kinetic law: 979477
product: 979465
product: 979453
reactant: 979441
fast: false
reversible: false
type: Reaction

metaid_0000015
constant: true
value: 0.05
type: Parameter

metaid_0000019
constant: true
value: 0.05
type: Parameter

metaid_0000202
kinetic law: 978195
product: 978183
reactant: 978171
reactant: 978159
fast: false
reversible: false
name: Factor VIIIai lipid binding
type: Reaction

977576
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

metaid_0000082
constant: true
value: 10.0
type: Parameter

metaid_0000092
constant: true
value: 0.01
type: Parameter

W3 CDTF: Fri Apr 20 22:54:24 BST 2012

979537
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

metaid_0000141
constant: false
boundary condition: false
has only substance units: false
initial concentration: 300.0
initial amount: NaN
in compartment: metaid_0000114
name: PS_f
type: Species

977600
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

980047
stoichiometry: 1.0
species: metaid_0000179
type: SpeciesReference

metaid_0000216
kinetic law: 978861
product: 978849
reactant: 978836
reactant: 978824
fast: false
reversible: false
name: X_IXa_VIIIa complex formation
type: Reaction

metaid_0000100
constant: true
value: 0.1
type: Parameter

metaid_0000016
constant: true
value: 0.227
type: Parameter

metaid_0000112
constant: true
value: 1.417
type: Parameter

979284
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

979236
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

979898
stoichiometry: 1.0
species: metaid_0000175
type: SpeciesReference

metaid_0000122
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Va_l
type: Species

metaid_0000142
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: PS_l
type: Species

979657
stoichiometry: 1.0
species: metaid_0000169
type: SpeciesReference

978256
stoichiometry: 1.0
species: metaid_0000147
type: SpeciesReference

980241
stoichiometry: 1.0
species: metaid_0000182
type: SpeciesReference

metaid_0000190
kinetic law: 977612
product: 977600
reactant: 977588
reactant: 977576
fast: false
reversible: false
name: Factor V lipid binding
type: Reaction

metaid_0000132
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IX_l
type: Species

979802
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

metaid_0000113
constant: true
value: 0.183
type: Parameter

980229
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

980144
stoichiometry: 1.0
species: metaid_0000181
type: SpeciesReference

metaid_0000123
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: metaid_0000114
name: VII_f
type: Species

979188
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

977503
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

977697
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000143
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIai_f
type: Species

977795
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

metaid_0000133
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IXa_f
type: Species

977831
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

978316
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

979886
stoichiometry: 1.0
species: metaid_0000172
type: SpeciesReference

metaid_0000110
constant: true
value: 0.5
type: Parameter

979272
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000124
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VII_l
type: Species

metaid_0000219
kinetic law: 979007
product: 978995
product: 978983
reactant: 978970
fast: false
reversible: false
name: Factor V activation
type: Reaction

metaid_0000144
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIai_l
type: Species

979645
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000130
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIIa_l
type: Species

978268
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000192
kinetic law: 977709
product: 977697
reactant: 977685
reactant: 977673
fast: false
reversible: false
name: Factor VII lipid binding
type: Reaction

metaid_0000239
kinetic law: 979959
product: 979947
reactant: 979934
reactant: 979922
fast: false
reversible: false
type: Reaction

978677
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

metaid_0000125
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000114
name: VIIa_f
type: Species

978873
stoichiometry: 1.0
species: metaid_0000159
type: SpeciesReference

metaid_0000111
constant: true
value: 0.01
type: Parameter

979742
stoichiometry: 1.0
species: metaid_0000144
type: SpeciesReference

980217
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

977891
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

metaid_0000145
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Vai_f
type: Species

978328
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

977685
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000131
constant: false
boundary condition: false
has only substance units: false
initial concentration: 90.0
initial amount: NaN
in compartment: metaid_0000114
name: IX_f
type: Species

metaid_0000191
kinetic law: 977660
product: 977648
reactant: 977636
reactant: 977624
fast: false
reversible: false
name: Factor Va lipid binding
type: Reaction

977770
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

979164
stoichiometry: 1.0
species: metaid_0000163
type: SpeciesReference

metaid_0000248
kinetic law: 980399
product: 980387
reactant: 980375
reactant: 980363
fast: false
reversible: false
type: Reaction

metaid_0000238
kinetic law: 979910
product: 979898
reactant: 979886
reactant: 979874
fast: false
reversible: false
type: Reaction

979609
stoichiometry: 1.0
species: metaid_0000168
type: SpeciesReference

979212
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000207
kinetic law: 978436
product: 978424
reactant: 978412
reactant: 978400
fast: false
reversible: false
name: IX_TF_VIIa binding
type: Reaction

979260
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

979079
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

979874
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000146
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Vai_l
type: Species

metaid_0000136
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: X_l
type: Species

978231
stoichiometry: 1.0
species: metaid_0000146
type: SpeciesReference

metaid_0000247
kinetic law: 980351
product: 980339
reactant: 980327
reactant: 980315
fast: false
reversible: false
type: Reaction

979019
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000237
kinetic law: 979862
product: 979850
product: 979838
reactant: 979826
fast: false
reversible: false
type: Reaction

metaid_0000147
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.0
initial amount: NaN
in compartment: metaid_0000114
name: PC_f
type: Species

979754
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

980168
stoichiometry: 1.0
species: metaid_0000181
type: SpeciesReference

metaid_0000208
kinetic law: 978484
product: 978472
product: 978460
reactant: 978448
fast: false
reversible: false
name: Factor IX activation
type: Reaction

978581
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

BIOMD0000000334
reaction: metaid_0000196
reaction: metaid_0000229
parameter: metaid_0000064
reaction: metaid_0000221
parameter: metaid_0000082
species: metaid_0000125
species: metaid_0000139
volume units: 858228
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notes: This model is from the article: A mathematical model of lipid-mediated thrombin generation Bungay Sharene D., Gentry Patricia A., Gentry Rodney D. Mathematical Medicine and Biology Volume 20, Issue 1, 1 March 2003, Pages 105-29 12974500 , Abstract: Thrombin is an enzyme that is generated in both vascular and non-vascular systems. In blood coagulation, a fundamental process in all species, thrombin induces the formation of a fibrin clot. A dynamical model of thrombin generation in the presence of lipid surfaces is presented. This model also includes the self-regulating thrombin feedback reactions, the thrombomodulin-protein C-protein S inhibitory system, tissue factor pathway inhibitor (TFPI), and the inhibitor, antithrombin (AT). The dynamics of this complex system were found to be highly lipid dependent, as would be expected from experimental studies. Simulations of this model indicate that a threshold lipid level is required to generate physiologically relevant amounts of thrombin. The dependence of the onset, the peak levels, and the duration of thrombin generation on lipid was saturable. The lipid concentration affects the way in which the inhibitors modulate thrombin production. A novel feature of this model is the inclusion of the dynamical protein C pathway, initiated by thrombin feedback. This inhibitory system exerts its effects on the lipid surface, where its substrates are formed. The maximum impact of TFPI occurs at intermediate vesicle concentrations. Inhibition by AT is only indirectly affected by the lipid since AT irreversibly binds only to solution phase proteins. In a system with normal plasma concentrations of the proteins involved in thrombin formation, the combination of these three inhibitors is sufficient both to effectively stop thrombin generation prior to the exhaustion of its precursor, prothrombin, and to inhibit all thrombin formed. This model can be used to predict thrombin generation under extreme lipid conditions that are difficult to…
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W3 CDTF: Tue Jan 08 18:06:42 GMT 2008