metaid_0000165
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_Va_II_l
type: Species

950313
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000231
kinetic law: 950325
product: 950313
product: 950301
reactant: 950289
fast: false
reversible: false
type: Reaction

949454
stoichiometry: 1.0
species: metaid_0000148
type: SpeciesReference

metaid_0000051
constant: true
value: 44.8
type: Parameter

metaid_0000107
constant: true
value: 3.6
type: Parameter

metaid_0000061
constant: true
value: 1.0
type: Parameter

metaid_0000175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_l
type: Species

metaid_0000211
kinetic law: 949697
product: 949685
product: 949673
reactant: 949661
fast: false
reversible: false
name: Factor Xa release
type: Reaction

949904
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

950181
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

metaid_0000205
kinetic law: 949515
product: 949503
reactant: 949491
reactant: 949479
fast: false
reversible: false
name: TF_VIIa binding
type: Reaction

metaid_0000012
constant: true
value: 0.17
type: Parameter

metaid_0000089
constant: true
value: 0.4
type: Parameter

949382
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

metaid_0000060
constant: true
value: 0.1
type: Parameter

metaid_0000079
constant: true
value: 44.8
type: Parameter

949298
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000251
kinetic law: 950955
product: 950943
reactant: 950931
reactant: 950919
fast: false
reversible: false
type: Reaction

950121
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

948926
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000212
kinetic law: 949745
product: 949733
reactant: 949721
reactant: 949709
fast: false
reversible: false
name: Xa_TF_VII binding
type: Reaction

metaid_0000106
constant: true
value: 6.4
type: Parameter

metaid_0000039
constant: true
value: 0.5
type: Parameter

949880
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

metaid_0000052
constant: true
value: 15.2
type: Parameter

metaid_0000062
constant: true
value: 0.043
type: Parameter

metaid_0000174
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_AT_f
type: Species

948950
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

metaid_0000049
constant: true
value: 1.0
type: Parameter

metaid_0000226
kinetic law: 950084
product: 950072
reactant: 950060
reactant: 950048
fast: false
reversible: false
type: Reaction

951016
stoichiometry: 1.0
species: metaid_0000255
type: SpeciesReference

metaid_0000011
constant: true
value: 0.057
type: Parameter

metaid_0000206
kinetic law: 949564
product: 949551
reactant: 949539
reactant: 949527
fast: false
reversible: false
name: TF_VII binding
type: Reaction

950301
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

950579
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

metaid_0000126
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: VIIa_l
type: Species

950024
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000038
constant: true
value: 11.5
type: Parameter

metaid_0000109
constant: true
value: 0.1
type: Parameter

metaid_0000163
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_IIa_l
type: Species

metaid_0000213
kinetic law: 949794
product: 949782
product: 949770
reactant: 949758
fast: false
reversible: false
name: TF_VII activation
type: Reaction

950289
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

metaid_0000223
kinetic law: 950036
product: 950024
product: 950012
reactant: 950000
fast: false
reversible: false
type: Reaction

metaid_0000243
kinetic law: 950663
product: 950651
reactant: 950639
reactant: 950627
fast: false
reversible: false
type: Reaction

metaid_0000177
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_PS_Va_l
type: Species

metaid_0000119
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.75
initial amount: NaN
in compartment: metaid_0000114
name: V_f
type: Species

950555
stoichiometry: 1.0
species: metaid_0000179
type: SpeciesReference

949214
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000203
kinetic law: 949418
product: 949406
reactant: 949394
reactant: 949382
fast: false
reversible: false
name: Factor Vai lipid binding
type: Reaction

metaid_0000263
kinetic law: 951052
product: 951040
reactant: 951028
reactant: 951016
fast: false
reversible: false
name: R34
type: Reaction

949286
stoichiometry: 1.0
species: metaid_0000139
type: SpeciesReference

950919
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

metaid_0000010
constant: true
value: 0.145
type: Parameter

948914
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000139
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_f
type: Species

949491
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

metaid_0000077
constant: true
value: 15.0
type: Parameter

metaid_0000162
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_f
type: Species

metaid_0000037
constant: true
value: 0.05
type: Parameter

metaid_0000050
constant: true
value: 0.05
type: Parameter

metaid_0000108
constant: true
value: 6.83E-6
type: Parameter

949782
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

950193
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

949637
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

metaid_0000244
kinetic law: 950711
product: 950699
product: 950687
reactant: 950675
fast: false
reversible: false
type: Reaction

950386
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

metaid_0000176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_Xa_TF_VIIa_l
type: Species

metaid_0000118
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_l
type: Species

metaid_0000204
kinetic law: 949466
product: 949454
reactant: 949442
reactant: 949430
fast: false
reversible: false
name: PC lipid binding
type: Reaction

949070
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000138
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Xa_l
type: Species

950603
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

950943
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

949806
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000078
constant: true
value: 0.05
type: Parameter

metaid_0000254
unit: 948890
name: nano mole
type: SBMLUnitsDef

949430
stoichiometry: 1.0
species: metaid_0000147
type: SpeciesReference

metaid_0000003
constant: true
value: 0.0043
type: Parameter

metaid_0000229
kinetic law: 950229
product: 950217
product: 950205
product: 950193
reactant: 950181
fast: false
reversible: false
type: Reaction

metaid_0000117
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: mIIa_f
type: Species

metaid_0000193
kinetic law: 949178
product: 949166
reactant: 949154
reactant: 949142
fast: false
reversible: false
name: Factor VIIa lipid binding
type: Reaction

949685
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000241
kinetic law: 950567
product: 950555
reactant: 950543
reactant: 950531
fast: false
reversible: false
type: Reaction

metaid_0000103
constant: true
value: 1.0
type: Parameter

metaid_0000215
kinetic law: 949843
product: 949831
reactant: 949819
reactant: 949806
fast: false
reversible: false
name: Va_Xa binding
type: Reaction

metaid_0000055
constant: true
value: 1.0
type: Parameter

metaid_0000046
constant: true
value: 0.1
type: Parameter

949479
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000036
constant: true
value: 0.17
type: Parameter

950895
stoichiometry: 1.0
species: metaid_0000186
type: SpeciesReference

metaid_0000255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 364.0
initial amount: NaN
in compartment: metaid_0000114
name: alpha2M_l
type: Species

metaid_0000075
constant: true
value: 66.0
type: Parameter

950543
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000016
constant: true
value: 0.227
type: Parameter

metaid_0000141
constant: false
boundary condition: false
has only substance units: false
initial concentration: 116.0
initial amount: NaN
in compartment: metaid_0000114
name: PS_f
type: Species

metaid_0000026
constant: true
value: 1.9
type: Parameter

metaid_0000151
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VII_l
type: Species

949106
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

949928
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000192
kinetic law: 949130
product: 949118
reactant: 949106
reactant: 949094
fast: false
reversible: false
name: Factor VII lipid binding
type: Reaction

949058
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000201
kinetic law: 949370
product: 949358
reactant: 949346
reactant: 949334
fast: false
reversible: false
name: PS lipid binding
type: Reaction

metaid_0000170
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_PS_l
type: Species

metaid_0000004
constant: false
boundary condition: false
has only substance units: false
initial concentration: 170000.0
initial amount: NaN
in compartment: metaid_0000114
name: LIPID
type: Species

949406
stoichiometry: 1.0
species: metaid_0000146
type: SpeciesReference

950931
stoichiometry: 1.0
species: metaid_0000140
type: SpeciesReference

metaid_0000035
constant: true
value: 0.057
type: Parameter

metaid_0000066
constant: true
value: 0.1
type: Parameter

metaid_0000242
kinetic law: 950615
product: 950603
reactant: 950591
reactant: 950579
fast: false
reversible: false
type: Reaction

metaid_0000116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: II_l
type: Species

metaid_0000056
constant: true
value: 1.0
type: Parameter

950000
stoichiometry: 1.0
species: metaid_0000163
type: SpeciesReference

metaid_0000160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_Xa_l
type: Species

949831
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000076
constant: true
value: 13.0
type: Parameter

949733
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

948890
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000015
constant: true
value: 0.05
type: Parameter

metaid_0000140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: APC_l
type: Species

950338
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

950350
stoichiometry: 1.0
species: metaid_0000170
type: SpeciesReference

metaid_0000025
constant: true
value: 0.01
type: Parameter

949770
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000150
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_l
type: Species

metaid_0000256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: alpha2M_IIa_l
type: Species

metaid_0000191
kinetic law: 949082
product: 949070
reactant: 949058
reactant: 949046
fast: false
reversible: false
name: Factor Va lipid binding
type: Reaction

metaid_0000067
constant: true
value: 6.94
type: Parameter

950096
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1174.5
initial amount: NaN
in compartment: metaid_0000114
name: II_f
type: Species

metaid_0000227
kinetic law: 950133
product: 950121
reactant: 950108
reactant: 950096
fast: false
reversible: false
type: Reaction

950883
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

metaid_0000173
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4721.0
initial amount: NaN
in compartment: metaid_0000114
name: AT_f
type: Species

metaid_0000048
constant: true
value: 1.5
type: Parameter

949442
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

949758
stoichiometry: 1.0
species: metaid_0000156
type: SpeciesReference

metaid_0000105
constant: true
value: 0.1
type: Parameter

949394
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

949673
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

950651
stoichiometry: 1.0
species: metaid_0000181
type: SpeciesReference

949819
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

949142
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

metaid_0000073
constant: true
value: 100.0
type: Parameter

metaid_0000014
constant: true
value: 0.66
type: Parameter

949118
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

950822
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

949916
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

950506
stoichiometry: 1.0
species: metaid_0000176
type: SpeciesReference

949709
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

950265
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

metaid_0000257
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: alpha2M_Xa_l
type: Species

metaid_0000087
constant: true
value: 0.1
type: Parameter

metaid_0000190
kinetic law: 949034
product: 949022
reactant: 949010
reactant: 948998
fast: false
reversible: false
name: Factor V lipid binding
type: Reaction

metaid_0000028
constant: true
value: 3.3
type: Parameter

950531
stoichiometry: 1.0
species: metaid_0000173
type: SpeciesReference

949094
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000114
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

metaid_0000068
constant: true
value: 0.23
type: Parameter

metaid_0000047
constant: true
value: 32.5
type: Parameter

metaid_0000172
constant: false
boundary condition: false
has only substance units: false
initial concentration: 12.3
initial amount: NaN
in compartment: metaid_0000114
name: TFPI_f
type: Species

950012
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000228
kinetic law: 950169
product: 950157
reactant: 950145
fast: false
reversible: false
type: Reaction

metaid_0000218
kinetic law: 949892
product: 949880
reactant: 949868
reactant: 949855
fast: false
reversible: false
name: V_Xa binding
type: Reaction

950798
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

metaid_0000230
kinetic law: 950277
product: 950265
reactant: 950253
reactant: 950241
fast: false
reversible: false
type: Reaction

metaid_0000104
constant: true
value: 0.5
type: Parameter

949202
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000074
constant: true
value: 0.1
type: Parameter

metaid_0000200
kinetic law: 949322
product: 949310
reactant: 949298
reactant: 949286
fast: false
reversible: false
name: APC lipid binding
type: Reaction

950362
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

metaid_0000088
constant: true
value: 1.6
type: Parameter

949721
stoichiometry: 1.0
species: metaid_0000151
type: SpeciesReference

metaid_0000013
constant: true
value: 0.05
type: Parameter

metaid_0000027
constant: true
value: 0.029
type: Parameter

metaid_0000029
constant: true
value: 0.05
type: Parameter

metaid_0000155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_Xa_l
type: Species

metaid_0000098
constant: true
value: 6.94
type: Parameter

950980
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000145
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: Vai_f
type: Species

W3 CDTF: Thu May 12 13:59:52 BST 2011

950835
stoichiometry: 1.0
species: metaid_0000140
type: SpeciesReference

948998
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

951028
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000042
constant: true
value: 0.005
type: Parameter

950786
stoichiometry: 1.0
species: metaid_0000184
type: SpeciesReference

949588
stoichiometry: 1.0
species: metaid_0000150
type: SpeciesReference

metaid_0000219
kinetic law: 949940
product: 949928
product: 949916
reactant: 949904
fast: false
reversible: false
name: Factor V activation
type: Reaction

950591
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000093
constant: true
value: 0.0011
type: Parameter

metaid_0000032
constant: true
value: 0.2
type: Parameter

metaid_0000008
constant: true
value: 0.475
type: Parameter

metaid_0000184
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_TM_l
type: Species

949855
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

949576
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

949527
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000259
constant: true
value: 2.5E-6
type: Parameter

metaid_0000097
constant: true
value: 0.1
type: Parameter

metaid_0000154
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: TF_VIIa_X_l
type: Species

949166
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

950241
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000041
constant: true
value: 0.005
type: Parameter

949358
stoichiometry: 1.0
species: metaid_0000142
type: SpeciesReference

949661
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

950157
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

950446
stoichiometry: 1.0
species: metaid_0000172
type: SpeciesReference

metaid_0000007
constant: true
value: 0.05
type: Parameter

950748
stoichiometry: 1.0
species: metaid_0000184
type: SpeciesReference

metaid_0000092
constant: true
value: 0.01
type: Parameter

metaid_0000239
kinetic law: 950519
product: 950506
reactant: 950494
reactant: 950482
fast: false
reversible: false
type: Reaction

metaid_0000031
constant: true
value: 0.05
type: Parameter

950434
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000185
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: IIa_TM_PC_l
type: Species

metaid_0000096
constant: true
value: 6.83E-6
type: Parameter

metaid_0000181
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_mIIa_l
type: Species

metaid_0000120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000114
name: V_l
type: Species

949952
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

950060
stoichiometry: 1.0
species: metaid_0000158
type: SpeciesReference

metaid_0000110
constant: true
value: 0.5
type: Parameter

949539
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

metaid_0000006
constant: true
value: 1.0
type: Parameter

950847
stoichiometry: 1.0
species: metaid_0000184
type: SpeciesReference

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950774
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metaid_0000099
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950253
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metaid_0000156
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metaid_0000121
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ORG:
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n:
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metaid_0000080
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950458
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metaid_0000183
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metaid_0000005
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950048
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metaid_0000122
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metaid_0000136
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metaid_0000149
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metaid_0000236
kinetic law: 950374
product: 950362
reactant: 950350
reactant: 950338
fast: false
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metaid_0000188
kinetic law: 948938
product: 948926
reactant: 948914
reactant: 948902
fast: false
reversible: false
name: Factor II lipid binding
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950723
stoichiometry: 1.0
species: metaid_0000183
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metaid_0000209
kinetic law: 949613
product: 949600
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reactant: 949576
fast: false
reversible: false
name: X_TF_VIIa complex formation
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949964
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950627
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species: metaid_0000118
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BIOMD0000000333
parameter: metaid_0000040
species: metaid_0000117
parameter: metaid_0000075
parameter: metaid_0000066
parameter: metaid_0000013
species: metaid_0000175
species: metaid_0000140
curated: true
species: metaid_0000154
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species: metaid_0000124
species: metaid_0000138
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species: metaid_0000121
reaction: metaid_0000249
parameter: metaid_0000062
parameter: metaid_0000097
reaction: metaid_0000189
parameter: metaid_0000078
parameter: metaid_0000016
type: SBMLModel
parameter: metaid_0000051
reaction: metaid_0000229
species: metaid_0000176
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reaction: metaid_0000230
species: metaid_0000151
reaction: metaid_0000192
species: metaid_0000135
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reaction: metaid_0000210
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species: metaid_0000148
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species: metaid_0000122
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species: metaid_0000173
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species: metaid_0000136
reaction: metaid_0000237
parameter: metaid_0000050
reaction: metaid_0000228
parameter: metaid_0000093
units def: metaid_0000254
reaction: metaid_0000201
parameter: metaid_0000060
species: metaid_0000181
species: metaid_0000163
is version of: GO:0007596
parameter: metaid_0000110
length unit: length
reaction: metaid_0000213
reaction: metaid_0000204
species: metaid_0000120
reaction: metaid_0000250
species: metaid_0000185
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species: metaid_0000256
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substance units: metaid_0000254
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notes: This model is from the article: Modelling thrombin generation in human ovarian follicular fluid Bungay Sharene D., Gentry Patricia A., Gentry Rodney D. Bulletin of Mathematical Biology Volume 68, Issue 8, 12 July 2006, Pages 2283-302 16838084 , Abstract: A mathematical model is constructed to study thrombin production in human ovarian follicular fluid. The model results show that the amount of thrombin that can be produced in ovarian follicular fluid is much lower than that in blood plasma, failing to reach the level required for fibrin formation, and thereby supporting the hypothesis that in follicular fluid thrombin functions to initiate cellular activities via intracellular signalling receptors. It is also concluded that the absence of the amplification pathway to thrombin production in follicular fluid is a major factor in restricting the amount of thrombin that can be produced. Titration of the initial concentrations of the various reactants in the model lead to predictions for the amount of tissue factor and phospholipid that is required to maintain thrombin production in the follicle, as well as to the conclusion that tissue factor pathway inhibitor has little effect on the time that thrombin generation is sustained. Numerical experiments to determine the effect of factor V, which is at a much reduced level in follicular fluid compared to plasma, and thrombomodulin, illustrate the importance for further experimental work to determine values for several parameters that have yet to be reported in the literature.
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metaid_0000179
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949334
stoichiometry: 1.0
species: metaid_0000141
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metaid_0000198
kinetic law: 949226
product: 949214
reactant: 949202
reactant: 949190
fast: false
reversible: false
name: Factor X lipid binding
type: Reaction

metaid_0000222
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product: 949976
reactant: 949964
reactant: 949952
fast: false
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type: Reaction

metaid_0000158
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initial concentration: 0.0
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name: Xa_Va_l
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949262
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949600
stoichiometry: 1.0
species: metaid_0000154
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metaid_0000262
kinetic law: 951004
product: 950992
reactant: 950980
reactant: 950967
fast: false
reversible: false
name: R33
type: Reaction

950687
stoichiometry: 1.0
species: metaid_0000118
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metaid_0000137
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metaid_0000123
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metaid_0000148
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949551
stoichiometry: 1.0
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950482
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metaid_0000189
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name: Factor mIIa lipid binding
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950072
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metaid_0000249
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950205
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metaid_0000199
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metaid_0000124
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950967
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metaid_0000147
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950398
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metaid_0000238
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type: Reaction

metaid_0000072
constant: true
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metaid_0000210
kinetic law: 949649
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fast: false
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name: Factor X activation
type: Reaction

metaid_0000186
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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name: mIIa_AT_l
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metaid_0000091
constant: true
value: 3.3E-4
type: Parameter

metaid_0000248
kinetic law: 950810
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fast: false
reversible: false
type: Reaction

949190
stoichiometry: 1.0
species: metaid_0000135
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metaid_0000040
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949976
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950992
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metaid_0000250
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metaid_0000125
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initial concentration: 0.1
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950494
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949238
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948902
stoichiometry: 1.0
species: metaid_0000115
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metaid_0000146
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initial concentration: 0.0
initial amount: NaN
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name: Vai_l
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metaid_0000135
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boundary condition: false
has only substance units: false
initial concentration: 142.85
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in compartment: metaid_0000114
name: X_f
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metaid_0000260
constant: true
value: 1.4E-6
type: Parameter

950145
stoichiometry: 1.0
species: metaid_0000165
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949022
stoichiometry: 1.0
species: metaid_0000120
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metaid_0000090
constant: true
value: 0.016
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metaid_0000009
constant: true
value: 0.05
type: Parameter

metaid_0000237
kinetic law: 950422
product: 950410
product: 950398
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fast: false
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type: Reaction

950217
stoichiometry: 100.0
species: metaid_0000004
type: SpeciesReference

metaid_0000247
kinetic law: 950761
product: 950748
reactant: 950736
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fast: false
reversible: false
type: Reaction

951040
stoichiometry: 1.0
species: metaid_0000257
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metaid_0000166
constant: false
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initial concentration: 0.0
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name: Xa_Va_mIIa_l
type: Species

W3 CDTF: Fri Mar 09 15:59:29 GMT 2012