045121
constant: true
value: 0.01
name: Ca2_0
type: Parameter

783880
stoichiometry: 1.0
species: 044760
type: SpeciesReference

782650
stoichiometry: 1.0
species: 044782
type: SpeciesReference

783349
stoichiometry: 1.0
species: 044731
type: SpeciesReference

044726
name: Ga_GTP_a_PDE_a_Ga_GTP
type: Species
is: SBO:0000296
has part: P27600
has only substance units: false
has part: CHEBI:15996
initial concentration: 0.0
in compartment: 044715
boundary condition: false
initial amount: NaN
constant: false
has part: P09174

782963
stoichiometry: 1.0
species: 044791
type: SpeciesReference

044736
has only substance units: false
initial amount: NaN
boundary condition: false
has part: CHEBI:15996
has part: P09174
initial concentration: 0.0
name: PDE_Ga_GTP
constant: false
type: Species
has part: P27600
is: SBO:0000296
in compartment: 044715

045057
constant: true
value: 0.0076429599557114
name: kRK1_0
type: Parameter

044878
kinetic law: 784048
product: 784036
reactant: 784024
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_6
type: Reaction

045131
constant: false
value: 0.0
name: mag
type: Parameter

045162
constant: false
value: 0.0
name: kG1_2
type: Parameter

781632
stoichiometry: 1.0
species: 044746
type: SpeciesReference

784847
stoichiometry: 1.0
species: 044726
type: SpeciesReference

045152
constant: false
value: 0.0
name: kA1_1
type: Parameter

045107
constant: true
value: 1.2
name: betadark
type: Parameter

045047
constant: true
value: 3.13E7
name: ArrTot
type: Parameter

044888
is version of: GO:0043241
kinetic law: 784350
reversible: false
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP
name: v_r16_0
reactant: 784314
fast: false
product: 784338
product: 784326
type: Reaction

783952
stoichiometry: 1.0
species: 044777
type: SpeciesReference

784799
stoichiometry: 1.0
species: 044737
type: SpeciesReference

045141
constant: false
value: 0.0
name: numConcFactor
type: Parameter

044725
constant: false
in compartment: 044715
boundary condition: false
is: SBO:0000296
has part: P27600
type: Species
name: Ga_GTP_PDE_a_Ga_GTP
has part: P09174
has part: CHEBI:15996
initial concentration: 0.0
has only substance units: false
initial amount: NaN

044848
kinetic law: 783072
product: 783060
reactant: 783048
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_1
type: Reaction

045122
constant: true
value: 0.381529
name: k1
type: Parameter

785063
stoichiometry: 1.0
species: 044798
type: SpeciesReference

045112
constant: true
value: 29.7778
name: Jdark
type: Parameter

045171
constant: false
value: 0.0
name: Rec_wCa2
type: Parameter

044735
boundary condition: false
has only substance units: false
initial amount: NaN
name: PDE
in compartment: 044715
constant: false
is: SBO:0000252
is version of: P09174
type: Species
initial concentration: 1.335E7

044838
reactant: 782674
type: Reaction
kinetic law: 782710
reversible: true
reactant: 782686
name: v_r5_6
is version of: GO:0006461
notes: Binding of activated R to Arrestin
fast: false
product: 782698

784786
stoichiometry: 1.0
species: 044723
type: SpeciesReference

781791
stoichiometry: 1.0
species: 044802
type: SpeciesReference

781595
stoichiometry: 1.0
species: 044802
type: SpeciesReference

045056
constant: true
value: 0.0
name: otherstimulus
type: Parameter

781901
stoichiometry: 1.0
species: 044797
type: SpeciesReference

045161
constant: false
value: 0.0
name: kG1_1
type: Parameter

784338
stoichiometry: 1.0
species: 044740
type: SpeciesReference

782300
stoichiometry: 1.0
species: 044772
type: SpeciesReference

045046
constant: true
value: 3000000.0
name: RGStot
type: Parameter

044738
name: R
in compartment: 044715
has only substance units: false
is version of: P15409
initial concentration: 3.6E9
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

782975
stoichiometry: 1.0
species: 044717
type: SpeciesReference

784919
stoichiometry: 1.0
species: 044800
type: SpeciesReference

782155
stoichiometry: 1.0
species: 044746
type: SpeciesReference

045170
constant: false
value: 0.0
name: E
type: Parameter

045059
constant: true
value: 0.6
name: omega
type: Parameter

044837
name: v_r5_5
reversible: true
fast: false
type: Reaction
notes: Binding of activated R to Arrestin
kinetic law: 782662
is version of: GO:0006461
product: 782650
reactant: 782626
reactant: 782638

784277
stoichiometry: 1.0
species: 044792
type: SpeciesReference

782819
stoichiometry: 1.0
species: 044765
type: SpeciesReference

785003
stoichiometry: 1.0
species: 044801
type: SpeciesReference

045164
constant: false
value: 0.0
name: kG1_3
type: Parameter

044876
kinetic law: 783976
product: 783964
reactant: 783952
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_4
type: Reaction

045045
constant: true
value: 35.0
name: Rectot
type: Parameter

781644
stoichiometry: 1.0
species: 044802
type: SpeciesReference

045150
constant: false
value: 0.0
name: kRK1_6
type: Parameter

045143
constant: false
value: 0.0
name: kRK1_1
type: Parameter

784835
stoichiometry: 1.0
species: 044725
type: SpeciesReference

781682
stoichiometry: 1.0
species: 044755
type: SpeciesReference

784362
stoichiometry: 1.0
species: 044750
type: SpeciesReference

045124
constant: true
value: 1.9094
name: k2
type: Parameter

044723
initial amount: NaN
in compartment: 044715
boundary condition: false
constant: false
has part: P27600
name: Ga_GTP
has part: CHEBI:15996
is: SBO:0000296
type: Species
has only substance units: false
initial concentration: 0.0

044737
initial amount: NaN
constant: false
has part: CHEBI:15996
type: Species
initial concentration: 0.0
in compartment: 044715
name: PDE_a_Ga_GTP
has part: P27600
is: SBO:0000296
boundary condition: false
has part: P09174
has only substance units: false

784931
stoichiometry: 1.0
species: 044722
type: SpeciesReference

044836
kinetic law: 782614
product: 782601
reversible: true
is version of: GO:0006461
type: Reaction
notes: Binding of activated R to Arrestin
name: v_r5_4
reactant: 782577
fast: false
reactant: 782589

045110
constant: true
value: 0.2
name: fCa
type: Parameter

782312
stoichiometry: 1.0
species: 044802
type: SpeciesReference

044808
name: v_r2_0
notes: Rn and RK binding before phospohorylation occurs
type: Reaction
reactant: 781595
reversible: true
product: 781608
fast: false
is version of: GO:0006461
kinetic law: 781620
reactant: 781583

044877
kinetic law: 784012
product: 784000
reactant: 783988
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_5
type: Reaction

045130
constant: false
value: 0.0
name: premag
type: Parameter

781583
stoichiometry: 1.0
species: 044740
type: SpeciesReference

784326
stoichiometry: 1.0
species: 044721
type: SpeciesReference

045106
constant: true
value: 2.5
name: m
type: Parameter

045144
constant: false
value: 0.0
name: kRK1_2
type: Parameter

044795
initial amount: NaN
constant: false
is: SBO:0000297
name: R6_Gt
boundary condition: false
type: Species
has part: C02456
in compartment: 044715
has part: Q8CFY0
has only substance units: false
initial concentration: 0.0

044732
has part: CHEBI:15996
in compartment: 044715
has only substance units: false
initial concentration: 0.0
has part: O35599
boundary condition: false
constant: false
has part: Q3U6B2
type: Species
initial amount: NaN
name: Ops_G_GTP
is: SBO:0000296

781694
stoichiometry: 1.0
species: 044802
type: SpeciesReference

784581
stoichiometry: 1.0
species: 044781
type: SpeciesReference

044722
initial concentration: 0.0
initial amount: NaN
has part: P27600
constant: false
has part: CHEBI:17552
has only substance units: false
name: Ga_GDP
is: SBO:0000296
in compartment: 044715
boundary condition: false
type: Species

045176
constant: false
value: 0.0
name: deltaJ
type: Parameter

783012
stoichiometry: 1.0
species: 044740
type: SpeciesReference

045103
constant: true
value: 1.0
name: Vcyto
type: Parameter

782674
stoichiometry: 1.0
species: 044717
type: SpeciesReference

782987
stoichiometry: 1.0
species: 044730
type: SpeciesReference

783325
stoichiometry: 1.0
species: 044731
type: SpeciesReference

045135
constant: false
value: 0.0
name: del
type: Parameter

781657
stoichiometry: 1.0
species: 044753
type: SpeciesReference

044731
has part: O35599
boundary condition: false
has part: Q3U6B2
name: Ops_G
has only substance units: false
constant: false
in compartment: 044715
type: Species
is: SBO:0000297
initial amount: NaN
initial concentration: 0.0

044796
has part: Q9WVL4
type: Species
initial concentration: 0.0
has part: C02456
has only substance units: false
boundary condition: false
name: R6_RKpost
initial amount: NaN
in compartment: 044715
constant: false
is: SBO:0000297

783626
stoichiometry: 1.0
species: 044763
type: SpeciesReference

784314
stoichiometry: 1.0
species: 044742
type: SpeciesReference

781925
stoichiometry: 1.0
species: 044745
type: SpeciesReference

044721
constant: false
initial amount: NaN
is: SBO:0000296
in compartment: 044715
has part: CHEBI:15996
initial concentration: 0.0
type: Species
boundary condition: false
name: G_GTP
has part: Q3U6B2
has only substance units: false

783675
stoichiometry: 1.0
species: 044772
type: SpeciesReference

045146
constant: false
value: 0.0
name: kRK1_3
type: Parameter

045104
constant: true
value: 0.17
name: Kc
type: Parameter

784943
stoichiometry: 1.0
species: 044737
type: SpeciesReference

785087
stoichiometry: 1.0
species: 044737
type: SpeciesReference

784374
stoichiometry: 1.0
species: 044721
type: SpeciesReference

782009
stoichiometry: 1.0
species: 044770
type: SpeciesReference

782686
stoichiometry: 1.0
species: 044790
type: SpeciesReference

044797
constant: false
is: SBO:0000297
type: Species
boundary condition: false
has part: Q9WVL4
has part: C02456
in compartment: 044715
name: R6_RKpre
has only substance units: false
initial amount: NaN
initial concentration: 0.0

783964
stoichiometry: 1.0
species: 044775
type: SpeciesReference

045147
constant: false
value: 0.0
name: kRK1_4
type: Parameter

045101
constant: true
value: 2.0
name: w
type: Parameter

044720
has only substance units: false
in compartment: 044715
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 0.6
type: Species
name: Ca2_free
is: SBO:0000247
is version of: CHEBI:29108
is version of: C00076

785159
stoichiometry: 1.0
species: 044737
type: SpeciesReference

045174
constant: false
value: 0.0
name: J
type: Parameter

045133
constant: false
value: 0.0
name: predur
type: Parameter

781997
stoichiometry: 1.0
species: 044762
type: SpeciesReference

044733
has part: Q8CFY0
has part: O35599
has only substance units: false
type: Species
in compartment: 044715
name: Ops_Gt
is: SBO:0000297
initial amount: NaN
boundary condition: false
initial concentration: 0.0
constant: false

044798
type: Species
name: RGS
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: false
initial concentration: 3000000.0
constant: false
is version of: O54828
in compartment: 044715

783614
stoichiometry: 1.0
species: 044728
type: SpeciesReference

045048
constant: true
value: 0.0
name: flashBG
type: Parameter

045173
constant: false
value: 0.0
name: alfamax
type: Parameter

785099
stoichiometry: 1.0
species: 044722
type: SpeciesReference

784386
stoichiometry: 1.0
species: 044746
type: SpeciesReference

782879
stoichiometry: 1.0
species: 044717
type: SpeciesReference

045134
constant: false
value: 0.0
name: dur
type: Parameter

781841
stoichiometry: 1.0
species: 044802
type: SpeciesReference

784955
stoichiometry: 1.0
species: 044798
type: SpeciesReference

782361
stoichiometry: 1.0
species: 044802
type: SpeciesReference

W3 CDTF: Tue Apr 19 15:28:57 BST 2011

783590
stoichiometry: 1.0
species: 044760
type: SpeciesReference

782336
stoichiometry: 1.0
species: 044787
type: SpeciesReference

045083
constant: true
value: 2.0
name: kGrecyc
type: Parameter

044791
has part: C02456
has part: P20443
boundary condition: false
in compartment: 044715
initial concentration: 0.0
is: SBO:0000297
initial amount: NaN
constant: false
type: Species
name: R6_Arr
has only substance units: false

782348
stoichiometry: 1.0
species: 044781
type: SpeciesReference

044916
kinetic law: 785364
reactant: 785352
notes: Efflux of Ca2+ via the Na+/Ca2+ - K+ exchanger. Note that intracellular Ca2 cannot be lower than Ca2_0
fast: false
reversible: false
name: v_r32
type: Reaction

783688
stoichiometry: 1.0
species: 044777
type: SpeciesReference

044902
kinetic law: 784859
product: 784847
reactant: 784835
notes: Here PDE has two Ga bound and both its subunits are active
is version of: GO:0031334
fast: false
reversible: false
name: v_r21
type: Reaction

044755
has only substance units: false
constant: false
type: Species
boundary condition: false
is version of: C02456
name: R2
is: SBO:0000252
initial amount: NaN
in compartment: 044715
initial concentration: 0.0

044831
kinetic law: 782421
fast: false
type: Reaction
is version of: GO:0043241
reversible: false
name: v_r4_6
product: 782397
product: 782409
reactant: 782385
notes: Dissociation of Rn and RK

BIOMD0000000326
reaction: 044905
parameter: 045059
species: 044723
reaction: 044816
reaction: 044847
parameter: 045072
parameter: 045146
parameter: 045084
species: 044793
species: 044752
parameter: 045161
species: 044770
parameter: 045173
species: 044800
area units: area
reaction: 044920
reaction: 044831
species: 044745
parameter: 045130
parameter: 045125
parameter: 045165
parameter: 045137
reaction: 044917
rule: 045020
reaction: 044828
species: 044747
species: 044797
species: 044740
species: 044776
rule: 045008
reaction: 044901
reaction: 044812
reaction: 044843
species: 044733
reaction: 044855
reaction: 044870
parameter: 045118
parameter: 045149
reaction: 044882
name: DellOrco2009_phototransduction
parameter: 045042
species: 044735
species: 044717
reaction: 044872
species: 044762
rule: 044988
parameter: 045046
rule: 044996
species: 044782
parameter: 045070
reaction: 044913
species: 044748
parameter: 045048
occurs in: http://identifiers.org/taxonomy/10090
reaction: 044836
reaction: 044867
parameter: 045061
species: 044757
parameter: 045135
parameter: 045054
parameter: 045150
reaction: 044896
rule: 044991
species: 044786
species: 044790
species: 044788
species: 044792
parameter: 045082
species: 044783
parameter: 045094
reaction: 044906
rule: 045031
reaction: 044817
reaction: 044848
rule: 045001
parameter: 045109
rule: 044990
parameter: 045162
parameter: 045174
species: 044796

044841
kinetic law: 782807
is version of: GO:0046155
reactant: 782771
notes: Arrestin mediated R -> ops
name: v_r6_2
fast: false
product: 782795
product: 782783
reversible: false
type: Reaction

044745
in compartment: 044715
initial concentration: 0.0
is version of: Q9WVL4
is: SBO:0000297
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is version of: P15409
name: R0_RKpre

784714
stoichiometry: 1.0
species: 044735
type: SpeciesReference

045082
constant: true
value: 200.0
name: kG7
type: Parameter

783493
stoichiometry: 1.0
species: 044743
type: SpeciesReference

044915
kinetic law: 785340
product: 785328
reactant: 785316
notes: Ca2+ association and dissociation from intracellular buffers, with total concentration eT
is version of: GO:0006816
fast: false
reversible: true
name: v_r31
type: Reaction

044868
is version of: GO:0006461
reversible: true
reactant: 783724
name: v_r13_5
type: Reaction
reactant: 783712
kinetic law: 783748
notes: Rhodopsin and transducin binding
fast: false
product: 783736

044901
reactant: 784786
reversible: false
type: Reaction
is version of: GO:0006461
fast: false
kinetic law: 784823
product: 784811
notes: Here PDE has two Ga bound but only one active subunit
reactant: 784799
name: v_r20

044858
kinetic law: 783373
product: 783361
reactant: 783349
notes: GTP binding to Ops_G, GDP is taken into account in the rate constant. We assume the same kinetics as in reactions v_r15_*
is version of: GO:0005525
fast: false
reversible: false
name: v_r10
type: Reaction

784653
stoichiometry: 1.0
species: 044721
type: SpeciesReference

044792
is: SBO:0000297
boundary condition: false
initial amount: NaN
type: Species
in compartment: 044715
constant: false
name: R6_G
initial concentration: 0.0
has only substance units: false
has part: C02456
has part: Q3U6B2

044715
is version of: GO:0005829
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol
type: Compartment

783566
stoichiometry: 1.0
species: 044728
type: SpeciesReference

782433
stoichiometry: 1.0
species: 044717
type: SpeciesReference

784991
stoichiometry: 1.0
species: 044798
type: SpeciesReference

785196
stoichiometry: 1.0
species: 044722
type: SpeciesReference

785147
stoichiometry: 1.0
species: 044722
type: SpeciesReference

045159
constant: false
value: 0.0
name: kA1_6
type: Parameter

044756
initial amount: NaN
has part: P20443
name: R2_Arr
boundary condition: false
is: SBO:0000297
has only substance units: false
in compartment: 044715
constant: false
type: Species
has part: C02456
initial concentration: 0.0

044830
kinetic law: 782373
notes: Dissociation of Rn and RK
reversible: false
reactant: 782336
product: 782348
type: Reaction
product: 782361
is version of: GO:0043241
name: v_r4_5
fast: false

044840
reversible: false
reactant: 782722
product: 782734
name: v_r6_1
notes: Arrestin mediated R -> ops
type: Reaction
product: 782747
kinetic law: 782759
fast: false
is version of: GO:0046155

044746
in compartment: 044715
initial concentration: 0.0
name: R1
boundary condition: false
constant: false
is version of: C02456
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

784205
stoichiometry: 1.0
species: 044775
type: SpeciesReference

045051
constant: true
value: 0.0
name: flash0Mag
type: Parameter

783289
stoichiometry: 1.0
species: 044733
type: SpeciesReference

044793
has only substance units: false
has part: C02456
has part: CHEBI:15996
name: R6_G_GTP
boundary condition: false
initial concentration: 0.0
in compartment: 044715
is: SBO:0000296
constant: false
initial amount: NaN
has part: Q3U6B2
type: Species

783228
stoichiometry: 1.0
species: 044790
type: SpeciesReference

045071
constant: true
value: 6.1172E-13
name: kOps
type: Parameter

044718
in compartment: 044715
is version of: C00076
name: Ca2_buff
has only substance units: false
is: SBO:0000247
boundary condition: false
is version of: CHEBI:29108
initial amount: NaN
type: Species
initial concentration: 42.857
constant: false

044857
kinetic law: 783337
product: 783325
reactant: 783313
notes: GDP dissociation from Ops_Gt, GDP is taken into account in the rate constant. Here we assume the same kinetics as in reactions v_r14_*
fast: false
reversible: true
name: v_r9
type: Reaction

784702
stoichiometry: 1.0
species: 044723
type: SpeciesReference

W3 CDTF: Fri Apr 01 13:40:49 BST 2011

044757
type: Species
has part: Q3U6B2
boundary condition: false
has only substance units: false
initial amount: NaN
has part: C02456
in compartment: 044715
name: R2_G
initial concentration: 0.0
is: SBO:0000297
constant: false

045091
constant: true
value: 21.0881
name: kP4
type: Parameter

781937
stoichiometry: 1.0
species: 044752
type: SpeciesReference

783663
stoichiometry: 1.0
species: 044728
type: SpeciesReference

045158
constant: false
value: 0.0
name: kA1_5
type: Parameter

044843
fast: false
product: 782891
kinetic law: 782903
product: 782879
is version of: GO:0046155
name: v_r6_4
notes: Arrestin mediated R -> ops
reversible: false
reactant: 782867
type: Reaction

044743
initial concentration: 0.0
constant: false
type: Species
in compartment: 044715
is: SBO:0000297
name: R0_Gt
has only substance units: false
boundary condition: false
has part: P15409
has part: Q8CFY0
initial amount: NaN

784470
stoichiometry: 1.0
species: 044721
type: SpeciesReference

783578
stoichiometry: 1.0
species: 044755
type: SpeciesReference

044913
is version of: GO:0050254
kinetic law: 785304
fast: false
notes: RK inhibition by Rec_2Ca (Rec_wCa2 is determined using QSSA and not directly)
reactant: 785268
type: Reaction
reversible: true
product: 785280
modifier: 785292
name: v_r30

782445
stoichiometry: 1.0
species: 044746
type: SpeciesReference

045080
constant: true
value: 2000.0
name: kG6
type: Parameter

783481
stoichiometry: 1.0
species: 044740
type: SpeciesReference

045070
constant: true
value: 0.0445091
name: kA3
type: Parameter

784109
stoichiometry: 1.0
species: 044750
type: SpeciesReference

044856
reversible: true
type: Reaction
reactant: 783265
reactant: 783277
kinetic law: 783301
product: 783289
notes: We assume the reverse reaction to occur with the same rate as v_r13_*
name: v_r8
is version of: GO:0006461
fast: false

045050
constant: true
value: 0.001
name: flash0Dur
type: Parameter

784665
stoichiometry: 1.0
species: 044723
type: SpeciesReference

044717
boundary condition: false
constant: false
is version of: P20443
has only substance units: false
is: SBO:0000252
in compartment: 044715
name: Arr
initial amount: NaN
type: Species
initial concentration: 3.13E7

044903
type: Reaction
reactant: 784883
is version of: GO:0006461
name: v_r22
reactant: 784871
product: 784895
reversible: false
kinetic law: 784907
fast: false
notes: RGS binds to a PDE-Ga complex with both active subunits to form a complex

044758
initial concentration: 0.0
has part: C02456
is: SBO:0000296
has part: Q3U6B2
boundary condition: false
constant: false
has part: CHEBI:15996
type: Species
name: R2_G_GTP
has only substance units: false
in compartment: 044715
initial amount: NaN

783988
stoichiometry: 1.0
species: 044786
type: SpeciesReference

785280
stoichiometry: 1.0
species: 044803
type: SpeciesReference

045090
constant: true
value: 1.49834E-9
name: kP3
type: Parameter

783120
stoichiometry: 1.0
species: 044763
type: SpeciesReference

785352
stoichiometry: 1.0
species: 044720
type: SpeciesReference

785135
stoichiometry: 1.0
species: 044726
type: SpeciesReference

044842
product: 782843
reactant: 782819
is version of: GO:0046155
product: 782831
reversible: false
kinetic law: 782855
name: v_r6_3
type: Reaction
notes: Arrestin mediated R -> ops
fast: false

044855
kinetic law: 783253
product: 783241
reactant: 783228
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_6
type: Reaction

044912
fast: false
reactant: 785220
kinetic law: 785256
reactant: 785232
reversible: false
product: 785244
type: Reaction
notes: Gt recycling... heterotrimer reconstitution
name: v_r29
is version of: GO:0032795

045043
constant: true
value: 3.6E8
name: Gtot
type: Parameter

785220
stoichiometry: 1.0
species: 044722
type: SpeciesReference

045156
constant: false
value: 0.0
name: kA1_4
type: Parameter

044865
notes: Rhodopsin and transducin binding
reactant: 783566
reversible: true
product: 783590
reactant: 783578
kinetic law: 783602
name: v_r13_2
type: Reaction
is version of: GO:0006461
fast: false

782081
stoichiometry: 1.0
species: 044787
type: SpeciesReference

782168
stoichiometry: 1.0
species: 044802
type: SpeciesReference

044845
product: 782939
is version of: GO:0046155
name: v_r6_5
reversible: false
reactant: 782915
product: 782927
notes: Arrestin mediated R -> ops
type: Reaction
kinetic law: 782951
fast: false

044835
notes: Binding of activated R to Arrestin
type: Reaction
name: v_r5_3
product: 782553
reactant: 782529
reversible: true
is version of: GO:0006461
fast: false
reactant: 782541
kinetic law: 782565

782747
stoichiometry: 1.0
species: 044730
type: SpeciesReference

782541
stoichiometry: 1.0
species: 044763
type: SpeciesReference

045042
constant: true
value: 1.335E7
name: PDEtot
type: Parameter

044911
kinetic law: 785208
product: 785196
reactant: 785184
notes: Here we assume, according to Felber et al. (1996) that Gt may hydrolize GTP to GDP, and hence inactivate
is version of: GO:0006184
fast: false
reversible: false
name: v_r28
type: Reaction

783542
stoichiometry: 1.0
species: 044751
type: SpeciesReference

045155
constant: false
value: 0.0
name: kA1_3
type: Parameter

785414
stoichiometry: 1.0
species: 044805
type: SpeciesReference

045165
constant: false
value: 0.0
name: kG1_4
type: Parameter

785039
stoichiometry: 1.0
species: 044722
type: SpeciesReference

784677
stoichiometry: 1.0
species: 044727
type: SpeciesReference

045052
constant: true
value: 0.0
name: flashDel
type: Parameter

783132
stoichiometry: 1.0
species: 044730
type: SpeciesReference

782409
stoichiometry: 1.0
species: 044802
type: SpeciesReference

784241
stoichiometry: 1.0
species: 044783
type: SpeciesReference

045092
constant: true
value: 0.033
name: kPDEshutoff
type: Parameter

782457
stoichiometry: 1.0
species: 044747
type: SpeciesReference

045109
constant: true
value: 4.3E-4
name: betasub
type: Parameter

044853
kinetic law: 783216
product: 783204
reactant: 783192
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_5
type: Reaction

044910
fast: false
kinetic law: 785171
product: 785159
type: Reaction
reactant: 785135
name: v_r27
product: 785147
notes: Inactivation of the aPDEa complex by Ga's GTPase capability; here we assume that the same rate constant as above applies
is version of: GO:0043241
reversible: false

045041
constant: true
value: 3.6E9
name: Rtot
type: Parameter

784726
stoichiometry: 1.0
species: 044736
type: SpeciesReference

785232
stoichiometry: 1.0
species: 044727
type: SpeciesReference

044867
notes: Rhodopsin and transducin binding
reversible: true
type: Reaction
reactant: 783675
kinetic law: 783700
fast: false
is version of: GO:0006461
reactant: 783663
name: v_r13_4
product: 783688

044900
kinetic law: 784774
product: 784762
reactant: 784750
is version of: GO:0031334
fast: false
reversible: false
name: v_r19
type: Reaction

045168
constant: false
value: 0.0
name: kG1_6
type: Parameter

045055
constant: true
value: 0.0
name: flashMag
type: Parameter

044767
has part: CHEBI:15996
has only substance units: false
is: SBO:0000296
type: Species
in compartment: 044715
initial amount: NaN
name: R3_G_GTP
has part: Q3U6B2
constant: false
boundary condition: false
initial concentration: 0.0
has part: C02456

044728
initial amount: NaN
name: Gt
constant: false
type: Species
in compartment: 044715
boundary condition: false
has only substance units: false
is: SBO:0000252
is version of: Q8CFY0
initial concentration: 3.6E8

045095
constant: true
value: 256.07
name: kRGS2
type: Parameter

044747
constant: false
in compartment: 044715
type: Species
has part: P20443
is: SBO:0000297
initial concentration: 0.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: R1_Arr
has part: C02456

782553
stoichiometry: 1.0
species: 044765
type: SpeciesReference

783204
stoichiometry: 1.0
species: 044730
type: SpeciesReference

044833
name: v_r5_2
type: Reaction
product: 782505
is version of: GO:0006461
reversible: true
reactant: 782493
reactant: 782481
fast: false
kinetic law: 782517
notes: Binding of activated R to Arrestin

783409
stoichiometry: 1.0
species: 044730
type: SpeciesReference

044847
kinetic law: 783036
product: 783024
reactant: 783012
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_0
type: Reaction

782601
stoichiometry: 1.0
species: 044773
type: SpeciesReference

044852
kinetic law: 783180
product: 783168
reactant: 783156
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_4
type: Reaction

045140
constant: false
value: 0.0
name: stimulus
type: Parameter

785027
stoichiometry: 1.0
species: 044801
type: SpeciesReference

783808
stoichiometry: 1.0
species: 044743
type: SpeciesReference

044920
kinetic law: 785486
modifier: 785474
modifier: 785462
reactant: 785450
notes: Hydrolysis by means of PDE
fast: false
reversible: false
name: v_r35
type: Reaction

045153
constant: false
value: 0.0
name: kA1_2
type: Parameter

045054
constant: true
value: 0.001
name: flashDur
type: Parameter

044866
reversible: true
reactant: 783626
type: Reaction
name: v_r13_3
kinetic law: 783651
notes: Rhodopsin and transducin binding
is version of: GO:0006461
fast: false
reactant: 783614
product: 783639

044790
constant: false
initial concentration: 0.0
is: SBO:0000252
type: Species
boundary condition: false
initial amount: NaN
is version of: C02456
name: R6
in compartment: 044715
has only substance units: false

785111
stoichiometry: 1.0
species: 044735
type: SpeciesReference

045167
constant: false
value: 0.0
name: kG1_5
type: Parameter

044768
has part: Q8CFY0
has part: C02456
in compartment: 044715
has only substance units: false
type: Species
initial amount: NaN
name: R3_Gt
boundary condition: false
initial concentration: 0.0
is: SBO:0000297
constant: false

044846
notes: Arrestin mediated R -> ops
product: 782975
kinetic law: 782999
fast: false
is version of: GO:0046155
type: Reaction
name: v_r6_6
product: 782987
reversible: false
reactant: 782963

044727
constant: false
initial amount: NaN
initial concentration: 0.0
is: SBO:0000297
type: Species
has only substance units: false
in compartment: 044715
name: Gbg
boundary condition: false
is version of: GO:0031680

044748
has part: Q3U6B2
boundary condition: false
has part: C02456
initial concentration: 0.0
has only substance units: false
name: R1_G
is: SBO:0000297
initial amount: NaN
in compartment: 044715
constant: false
type: Species

045094
constant: true
value: 1.57E-7
name: kRGS1
type: Parameter

784253
stoichiometry: 1.0
species: 044785
type: SpeciesReference

ORG:
  orgname: University of Oldenburg, Institute of Biology and Environmental Sciences
n:
  given: Daniele
  family: Dell'Orco

044832
kinetic law: 782469
is version of: GO:0006461
notes: Binding of activated R to Arrestin
reactant: 782433
fast: false
reactant: 782445
name: v_r5_1
product: 782457
type: Reaction
reversible: true

044822
kinetic law: 782093
product: 782081
reactant: 782069
notes: Phosphorylation of Rn to Rn+1. In these reactions ATP (left) and ADP (right) are included in the rate constants
is version of: GO:0016310
fast: false
reversible: false
name: v_r3_4
type: Reaction

045098
constant: true
value: 0.610084
name: kRec4
type: Parameter

783784
stoichiometry: 1.0
species: 044795
type: SpeciesReference

045084
constant: true
value: 0.05
name: kGshutoff
type: Parameter

783433
stoichiometry: 1.0
species: 044730
type: SpeciesReference

783168
stoichiometry: 1.0
species: 044730
type: SpeciesReference

784533
stoichiometry: 1.0
species: 044772
type: SpeciesReference

782638
stoichiometry: 1.0
species: 044781
type: SpeciesReference

781829
stoichiometry: 1.0
species: 044781
type: SpeciesReference

044872
kinetic law: 783868
product: 783856
reactant: 783844
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_1
type: Reaction

044750
constant: false
has part: Q3U6B2
initial concentration: 0.0
name: R1_G_GTP
has part: C02456
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000296
in compartment: 044715
initial amount: NaN
has part: CHEBI:15996

783469
stoichiometry: 1.0
species: 044728
type: SpeciesReference

045064
constant: true
value: 20.0
name: kRK4
type: Parameter

044778
boundary condition: false
has part: C02456
name: R4_RKpost
type: Species
has part: Q9WVL4
has only substance units: false
initial amount: NaN
initial concentration: 0.0
in compartment: 044715
constant: false
is: SBO:0000297

044862
name: v_r13_0
reactant: 783469
type: Reaction
product: 783493
is version of: GO:0006461
reversible: true
notes: Rhodopsin and transducin binding
fast: false
kinetic law: 783505
reactant: 783481

044760
boundary condition: false
in compartment: 044715
is: SBO:0000297
has part: Q8CFY0
name: R2_Gt
initial concentration: 0.0
type: Species
initial amount: NaN
constant: false
has part: C02456
has only substance units: false

784290
stoichiometry: 1.0
species: 044793
type: SpeciesReference

044788
name: R5_RKpre
constant: false
is: SBO:0000297
has part: C02456
type: Species
boundary condition: false
has only substance units: false
has part: Q9WVL4
initial concentration: 0.0
in compartment: 044715
initial amount: NaN

045078
constant: true
value: 600.0
name: kG4_GDP
type: Parameter

044823
kinetic law: 782130
product: 782118
reactant: 782106
notes: Phosphorylation of Rn to Rn+1. In these reactions ATP (left) and ADP (right) are included in the rate constants
is version of: GO:0016310
fast: false
reversible: false
name: v_r3_5
type: Reaction

783241
stoichiometry: 1.0
species: 044730
type: SpeciesReference

044777
name: R4_Gt
is: SBO:0000297
initial concentration: 0.0
in compartment: 044715
has part: C02456
has part: Q8CFY0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

784434
stoichiometry: 1.0
species: 044755
type: SpeciesReference

044873
kinetic law: 783904
product: 783892
reactant: 783880
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_2
type: Reaction

782577
stoichiometry: 1.0
species: 044717
type: SpeciesReference

044863
kinetic law: 783554
reactant: 783517
is version of: GO:0006461
reactant: 783529
product: 783542
fast: false
type: Reaction
name: v_r13_1
reversible: true
notes: Rhodopsin and transducin binding

045079
constant: true
value: 750.0
name: kG5_GTP
type: Parameter

784520
stoichiometry: 1.0
species: 044721
type: SpeciesReference

044787
initial concentration: 0.0
type: Species
boundary condition: false
has part: C02456
is: SBO:0000297
in compartment: 044715
constant: false
initial amount: NaN
has part: Q9WVL4
has only substance units: false
name: R5_RKpost

044860
reactant: 783385
kinetic law: 783421
fast: false
notes: Ops_G_GTP dissociation to Ops and G_GTP, here G_GTP is the Gt heterotrimer with bound GTP. We assume the same kinetics as in reactions v_r16_*
reversible: false
type: Reaction
product: 783409
name: v_r11
is version of: GO:0043241
product: 783397

044820
kinetic law: 782021
product: 782009
reactant: 781997
notes: Phosphorylation of Rn to Rn+1. In these reactions ATP (left) and ADP (right) are included in the rate constants
is version of: GO:0016310
fast: false
reversible: false
name: v_r3_2
type: Reaction

044762
is: SBO:0000297
has only substance units: false
name: R2_RKpre
boundary condition: false
initial amount: NaN
in compartment: 044715
constant: false
initial concentration: 0.0
has part: Q9WVL4
type: Species
has part: C02456

781730
stoichiometry: 1.0
species: 044763
type: SpeciesReference

044810
reactant: 781644
name: v_r2_1
fast: false
is version of: GO:0006461
reversible: true
reactant: 781632
kinetic law: 781669
notes: Rn and RK binding before phospohorylation occurs
type: Reaction
product: 781657

045086
constant: true
value: 0.0549715
name: kP1
type: Parameter

784762
stoichiometry: 1.0
species: 044737
type: SpeciesReference

045066
constant: true
value: 0.81323
name: omega_arr
type: Parameter

044776
name: R4_G_GTP
has part: Q3U6B2
constant: false
boundary condition: false
initial concentration: 0.0
is: SBO:0000296
initial amount: NaN
has only substance units: false
has part: CHEBI:15996
in compartment: 044715
has part: C02456
type: Species

783445
stoichiometry: 1.0
species: 044738
type: SpeciesReference

783156
stoichiometry: 1.0
species: 044772
type: SpeciesReference

783517
stoichiometry: 1.0
species: 044728
type: SpeciesReference

045076
constant: true
value: 2000.0
name: kG3
type: Parameter

785268
stoichiometry: 1.0
species: 044802
type: SpeciesReference

045097
constant: true
value: 9.68777
name: kRec3
type: Parameter

044821
kinetic law: 782057
product: 782045
reactant: 782033
notes: Phosphorylation of Rn to Rn+1. In these reactions ATP (left) and ADP (right) are included in the rate constants
is version of: GO:0016310
fast: false
reversible: false
name: v_r3_3
type: Reaction

045087
constant: true
value: 0.0
name: kP1_rev
type: Parameter

783916
stoichiometry: 1.0
species: 044768
type: SpeciesReference

044811
notes: Rn and RK binding before phospohorylation occurs
reactant: 781694
reversible: true
kinetic law: 781718
reactant: 781682
name: v_r2_2
type: Reaction
product: 781706
fast: false
is version of: GO:0006461

783856
stoichiometry: 1.0
species: 044748
type: SpeciesReference

784181
stoichiometry: 1.0
species: 044767
type: SpeciesReference

044875
kinetic law: 783940
product: 783928
reactant: 783916
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_3
type: Reaction

784000
stoichiometry: 1.0
species: 044783
type: SpeciesReference

044775
boundary condition: false
initial concentration: 0.0
has part: C02456
type: Species
is: SBO:0000297
in compartment: 044715
constant: false
initial amount: NaN
has only substance units: false
name: R4_G
has part: Q3U6B2

045067
constant: true
value: 6.0918E-10
name: kArr
type: Parameter

784097
stoichiometry: 1.0
species: 044748
type: SpeciesReference

044761
is: SBO:0000297
boundary condition: false
has part: Q9WVL4
initial amount: NaN
type: Species
constant: false
in compartment: 044715
has part: C02456
has only substance units: false
name: R2_RKpost
initial concentration: 0.0

044861
kinetic law: 783457
product: 783445
reactant: 783433
notes: Similarly to Firsov et al. (2006) we consider the rate of Rho regeneration from Ops + 11cis_ret combination as a first order kinetics with the rate constant kRecyc implicitely including 11cis_ret concentration. See paper for details.
is version of: GO:0016063
fast: false
reversible: false
name: v_r12
type: Reaction

045088
constant: true
value: 940.706
name: kP2
type: Parameter

782385
stoichiometry: 1.0
species: 044796
type: SpeciesReference

783529
stoichiometry: 1.0
species: 044746
type: SpeciesReference

784217
stoichiometry: 1.0
species: 044776
type: SpeciesReference

784750
stoichiometry: 1.0
species: 044736
type: SpeciesReference

782722
stoichiometry: 1.0
species: 044747
type: SpeciesReference

045074
constant: true
value: 3.0586111111E-5
name: kG1_0
type: Parameter

045060
constant: true
value: 250.0
name: kRK2
type: Parameter

785184
stoichiometry: 1.0
species: 044723
type: SpeciesReference

783760
stoichiometry: 1.0
species: 044728
type: SpeciesReference

044905
is version of: GO:0043241
kinetic law: 784967
reversible: false
type: Reaction
product: 784931
notes: One out of two PDE subunits is deactivated and one GTP is hydrolyzed
name: v_r23
product: 784955
product: 784943
reactant: 784919
fast: false

784605
stoichiometry: 1.0
species: 044793
type: SpeciesReference

782033
stoichiometry: 1.0
species: 044771
type: SpeciesReference

784557
stoichiometry: 1.0
species: 044785
type: SpeciesReference

781742
stoichiometry: 1.0
species: 044802
type: SpeciesReference

044753
initial amount: NaN
name: R1_RKpre
has only substance units: false
constant: false
in compartment: 044715
initial concentration: 0.0
type: Species
has part: Q9WVL4
boundary condition: false
has part: C02456
is: SBO:0000297

781804
stoichiometry: 1.0
species: 044780
type: SpeciesReference

782529
stoichiometry: 1.0
species: 044717
type: SpeciesReference

784036
stoichiometry: 1.0
species: 044792
type: SpeciesReference

044783
initial amount: NaN
has part: Q3U6B2
has only substance units: false
initial concentration: 0.0
is: SBO:0000297
boundary condition: false
in compartment: 044715
constant: false
has part: C02456
name: R5_G
type: Species

785316
stoichiometry: 1.0
species: 044720
type: SpeciesReference

044763
in compartment: 044715
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: R3
is: SBO:0000252
constant: false
type: Species
boundary condition: false
is version of: C02456

783313
stoichiometry: 1.0
species: 044733
type: SpeciesReference

045061
constant: true
value: 10838.0
name: RKdark
type: Parameter

783928
stoichiometry: 1.0
species: 044766
type: SpeciesReference

045075
constant: true
value: 2250.34
name: kG2
type: Parameter

783265
stoichiometry: 1.0
species: 044728
type: SpeciesReference

044906
fast: false
reactant: 784991
reactant: 784979
type: Reaction
notes: RGS binds to a PDE-Ga complex with one active subunit to form a complex. Here we assume that the association rate constant is the same as in v_r22
name: v_r24
is version of: GO:0006461
product: 785003
reversible: false
kinetic law: 785015

781559
stoichiometry: 1.0
species: 044740
type: SpeciesReference

782481
stoichiometry: 1.0
species: 044717
type: SpeciesReference

044773
is: SBO:0000297
name: R4_Arr
in compartment: 044715
type: Species
has part: P20443
has only substance units: false
constant: false
boundary condition: false
initial concentration: 0.0
initial amount: NaN
has part: C02456

784458
stoichiometry: 1.0
species: 044767
type: SpeciesReference

783712
stoichiometry: 1.0
species: 044728
type: SpeciesReference

044772
in compartment: 044715
constant: false
name: R4
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 0.0
type: Species
is version of: C02456
is: SBO:0000252

782734
stoichiometry: 1.0
species: 044717
type: SpeciesReference

044850
kinetic law: 783108
product: 783096
reactant: 783084
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_2
type: Reaction

044752
has part: Q9WVL4
constant: false
type: Species
in compartment: 044715
has part: C02456
initial concentration: 0.0
name: R1_RKpost
is: SBO:0000297
has only substance units: false
initial amount: NaN
boundary condition: false

044870
name: v_r13_6
type: Reaction
is version of: GO:0006461
reactant: 783760
fast: false
notes: Rhodopsin and transducin binding
reactant: 783772
reversible: true
kinetic law: 783796
product: 783784

782626
stoichiometry: 1.0
species: 044717
type: SpeciesReference

782397
stoichiometry: 1.0
species: 044790
type: SpeciesReference

044891
kinetic law: 784446
is version of: GO:0043241
product: 784434
reactant: 784410
type: Reaction
name: v_r16_2
fast: false
product: 784422
reversible: false
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP

784483
stoichiometry: 1.0
species: 044763
type: SpeciesReference

044766
type: Species
is: SBO:0000297
initial concentration: 0.0
has part: Q3U6B2
has only substance units: false
initial amount: NaN
boundary condition: false
has part: C02456
name: R3_G
in compartment: 044715
constant: false

044786
constant: false
has only substance units: false
initial amount: NaN
in compartment: 044715
has part: Q8CFY0
has part: C02456
is: SBO:0000297
type: Species
name: R5_Gt
initial concentration: 0.0
boundary condition: false

044907
type: Reaction
fast: false
name: v_r25
product: 785063
reactant: 785027
product: 785039
notes: The PDE subunit is deactivated and GTP is hydrolyzed. Here we assume that the deactivation/dissociation rate constant is the same as in v_r23
product: 785051
kinetic law: 785075
is version of: GO:0043241
reversible: false

781754
stoichiometry: 1.0
species: 044771
type: SpeciesReference

785450
stoichiometry: 1.0
species: 044805
type: SpeciesReference

044917
kinetic law: 785402
modifier: 785390
product: 785377
notes: Influx of extracellular Ca2+ through cGMP-gated cation channels
fast: false
reversible: false
name: v_r33
type: Reaction

045072
constant: true
value: 7.0E-4
name: kRrecyc
type: Parameter

783772
stoichiometry: 1.0
species: 044790
type: SpeciesReference

044771
has only substance units: false
type: Species
is: SBO:0000297
has part: Q9WVL4
boundary condition: false
initial concentration: 0.0
constant: false
has part: C02456
name: R3_RKpre
in compartment: 044715
initial amount: NaN

782589
stoichiometry: 1.0
species: 044772
type: SpeciesReference

044851
kinetic law: 783144
product: 783132
reactant: 783120
notes: Thermal decay of R's catalytic active form MetaII. Rate constant from Xu et al. We assume that the rate constant is independent of the phosphorylation state. See Mitchell DC, Kibelbek J, Litman BJ. (Biochemistry, 1992) for further detail
is version of: GO:0046155
fast: false
reversible: false
name: v_r7_3
type: Reaction

784024
stoichiometry: 1.0
species: 044795
type: SpeciesReference

044751
is: SBO:0000297
has only substance units: false
name: R1_Gt
in compartment: 044715
initial amount: NaN
initial concentration: 0.0
constant: false
has part: Q8CFY0
type: Species
boundary condition: false
has part: C02456

044871
kinetic law: 783832
product: 783820
reactant: 783808
notes: GDP dissociation from Rn_Gt. GDP is taken into account in the rate constant
is version of: GO:0046154
fast: false
reversible: true
name: v_r14_0
type: Reaction

782771
stoichiometry: 1.0
species: 044756
type: SpeciesReference

783192
stoichiometry: 1.0
species: 044781
type: SpeciesReference

044765
initial amount: NaN
in compartment: 044715
initial concentration: 0.0
has only substance units: false
constant: false
type: Species
has part: P20443
name: R3_Arr
boundary condition: false
has part: C02456
is: SBO:0000297

044890
name: v_r16_1
product: 784374
product: 784386
fast: false
reactant: 784362
reversible: false
is version of: GO:0043241
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP
type: Reaction
kinetic law: 784398

044785
initial amount: NaN
has part: CHEBI:15996
has part: C02456
in compartment: 044715
name: R5_G_GTP
type: Species
initial concentration: 0.0
has only substance units: false
has part: Q3U6B2
constant: false
boundary condition: false
is: SBO:0000296

782216
stoichiometry: 1.0
species: 044802
type: SpeciesReference

782493
stoichiometry: 1.0
species: 044755
type: SpeciesReference

784508
stoichiometry: 1.0
species: 044776
type: SpeciesReference

044908
name: v_r26
type: Reaction
kinetic law: 785123
product: 785099
reactant: 785087
notes: Inactivation of the PDEa complex by Ga's GTPase capability
is version of: GO:0006461
reversible: false
product: 785111
fast: false

785244
stoichiometry: 1.0
species: 044728
type: SpeciesReference

783361
stoichiometry: 1.0
species: 044732
type: SpeciesReference

783277
stoichiometry: 1.0
species: 044730
type: SpeciesReference

045063
constant: true
value: 400.0
name: kRK3_ATP
type: Parameter

044918
kinetic law: 785438
modifier: 785426
product: 785414
notes: Synthesis by means of Guanylyl cyclase
fast: false
reversible: false
name: v_r34
type: Reaction

781547
stoichiometry: 1.0
species: 044738
type: SpeciesReference

781608
stoichiometry: 1.0
species: 044745
type: SpeciesReference

044883
kinetic law: 784193
product: 784181
reactant: 784169
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_3
type: Reaction

781779
stoichiometry: 1.0
species: 044772
type: SpeciesReference

782142
stoichiometry: 1.0
species: 044752
type: SpeciesReference

783820
stoichiometry: 1.0
species: 044741
type: SpeciesReference

044802
initial amount: NaN
name: RK
is version of: Q9WVL4
type: Species
has only substance units: false
initial concentration: 10838.0
constant: false
boundary condition: false
is: SBO:0000252
in compartment: 044715

783736
stoichiometry: 1.0
species: 044786
type: SpeciesReference

782204
stoichiometry: 1.0
species: 044755
type: SpeciesReference

784979
stoichiometry: 1.0
species: 044737
type: SpeciesReference

045100
constant: true
value: 0.425272
name: Kp
type: Parameter

044816
is version of: GO:0006461
reactant: 781889
reactant: 781877
notes: Rn and RK binding before phospohorylation occurs
reversible: true
product: 781901
type: Reaction
fast: false
kinetic law: 781913
name: v_r2_6

044780
initial amount: NaN
has only substance units: false
has part: Q9WVL4
name: R4_RKpre
boundary condition: false
is: SBO:0000297
in compartment: 044715
constant: false
has part: C02456
type: Species
initial concentration: 0.0

781706
stoichiometry: 1.0
species: 044762
type: SpeciesReference

044893
is version of: GO:0043241
product: 784520
name: v_r16_4
reversible: false
type: Reaction
fast: false
reactant: 784508
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP
kinetic law: 784545
product: 784533

783084
stoichiometry: 1.0
species: 044755
type: SpeciesReference

782831
stoichiometry: 1.0
species: 044717
type: SpeciesReference

782505
stoichiometry: 1.0
species: 044756
type: SpeciesReference

782939
stoichiometry: 1.0
species: 044730
type: SpeciesReference

044770
is: SBO:0000297
constant: false
has part: C02456
initial amount: NaN
in compartment: 044715
initial concentration: 0.0
type: Species
has only substance units: false
has part: Q9WVL4
name: R3_RKpost
boundary condition: false

782783
stoichiometry: 1.0
species: 044717
type: SpeciesReference

045119
constant: true
value: 0.6
name: Ca2dark
type: Parameter

784629
stoichiometry: 1.0
species: 044790
type: SpeciesReference

044803
has only substance units: false
in compartment: 044715
boundary condition: false
constant: false
name: Rec_wCa2_RK
is: SBO:0000296
type: Species
initial concentration: 4204560.0
has part: Q9WVL4
has part: CHEBI:29108
has part: P34057
initial amount: NaN

781973
stoichiometry: 1.0
species: 044761
type: SpeciesReference

045149
constant: false
value: 0.0
name: kRK1_5
type: Parameter

784145
stoichiometry: 1.0
species: 044758
type: SpeciesReference

044892
reversible: false
reactant: 784458
is version of: GO:0043241
product: 784470
fast: false
kinetic law: 784496
name: v_r16_3
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP
product: 784483
type: Reaction

044730
constant: false
initial amount: NaN
is version of: O35599
name: Ops
type: Species
in compartment: 044715
is: SBO:0000252
boundary condition: false
has only substance units: false
initial concentration: 0.0

044817
kinetic law: 781949
product: 781937
reactant: 781925
notes: Phosphorylation of Rn to Rn+1. In these reactions ATP (left) and ADP (right) are included in the rate constants
is version of: GO:0016310
fast: false
reversible: false
name: v_r3_0
type: Reaction

783024
stoichiometry: 1.0
species: 044730
type: SpeciesReference

783639
stoichiometry: 1.0
species: 044768
type: SpeciesReference

044740
is: SBO:0000252
boundary condition: false
initial concentration: 0.0
has only substance units: false
name: R0
has part: P15409
constant: false
type: Species
in compartment: 044715
initial amount: NaN

044882
kinetic law: 784157
product: 784145
reactant: 784133
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_2
type: Reaction

783724
stoichiometry: 1.0
species: 044781
type: SpeciesReference

781853
stoichiometry: 1.0
species: 044788
type: SpeciesReference

783385
stoichiometry: 1.0
species: 044732
type: SpeciesReference

045118
constant: true
value: 47.554
name: gammaCa
type: Parameter

044895
product: 784581
type: Reaction
fast: false
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP
name: v_r16_5
product: 784569
is version of: GO:0043241
kinetic law: 784593
reversible: false
reactant: 784557

044800
has only substance units: false
type: Species
initial amount: NaN
has part: CHEBI:15996
initial concentration: 0.0
has part: P27600
has part: P09174
has part: O54828
name: RGS_Ga_GTP_a_PDE_a_Ga_GTP
in compartment: 044715
constant: false
boundary condition: false
is: SBO:0000296

782288
stoichiometry: 1.0
species: 044778
type: SpeciesReference

785328
stoichiometry: 1.0
species: 044718
type: SpeciesReference

044818
kinetic law: 781985
product: 781973
reactant: 781961
notes: Phosphorylation of Rn to Rn+1. In these reactions ATP (left) and ADP (right) are included in the rate constants
is version of: GO:0016310
fast: false
reversible: false
name: v_r3_1
type: Reaction

783096
stoichiometry: 1.0
species: 044730
type: SpeciesReference

782795
stoichiometry: 1.0
species: 044730
type: SpeciesReference

044782
name: R5_Arr
initial concentration: 0.0
has part: P20443
has only substance units: false
is: SBO:0000297
constant: false
boundary condition: false
initial amount: NaN
in compartment: 044715
type: Species
has part: C02456

044881
kinetic law: 784121
product: 784109
reactant: 784097
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_1
type: Reaction

784895
stoichiometry: 1.0
species: 044800
type: SpeciesReference

044741
in compartment: 044715
name: R0_G
has only substance units: false
boundary condition: false
constant: false
initial concentration: 0.0
initial amount: NaN
has part: Q3U6B2
type: Species
has part: P15409
is: SBO:0000297

044828
reactant: 782288
name: v_r4_4
product: 782300
reversible: false
product: 782312
notes: Dissociation of Rn and RK
fast: false
is version of: GO:0043241
kinetic law: 782324
type: Reaction

045138
constant: false
value: 0.0
name: testflash
type: Parameter

782843
stoichiometry: 1.0
species: 044730
type: SpeciesReference

782045
stoichiometry: 1.0
species: 044778
type: SpeciesReference

784569
stoichiometry: 1.0
species: 044721
type: SpeciesReference

781961
stoichiometry: 1.0
species: 044753
type: SpeciesReference

784617
stoichiometry: 1.0
species: 044721
type: SpeciesReference

044801
is: SBO:0000296
has part: CHEBI:15996
initial concentration: 0.0
initial amount: NaN
type: Species
has part: P09174
has only substance units: false
in compartment: 044715
boundary condition: false
has part: P27600
constant: false
has part: O54828
name: RGS_PDE_a_Ga_GTP

044781
has only substance units: false
in compartment: 044715
initial concentration: 0.0
is version of: C02456
is: SBO:0000252
constant: false
boundary condition: false
name: R5
initial amount: NaN
type: Species

782698
stoichiometry: 1.0
species: 044791
type: SpeciesReference

044742
boundary condition: false
is: SBO:0000296
has part: CHEBI:15996
initial concentration: 0.0
has part: Q3U6B2
constant: false
has only substance units: false
has part: P15409
initial amount: NaN
name: R0_G_GTP
type: Species
in compartment: 044715

044880
kinetic law: 784084
product: 784072
reactant: 784060
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_0
type: Reaction

045137
constant: false
value: 0.0
name: preflash
type: Parameter

784133
stoichiometry: 1.0
species: 044757
type: SpeciesReference

784883
stoichiometry: 1.0
species: 044798
type: SpeciesReference

044897
fast: false
type: Reaction
reactant: 784653
kinetic law: 784689
product: 784665
is version of: GO:0007201
product: 784677
name: v_r17
reversible: false
notes: Dissociation of trimeric Gt into alpha and beta-gamma subunits

783060
stoichiometry: 1.0
species: 044730
type: SpeciesReference

782106
stoichiometry: 1.0
species: 044788
type: SpeciesReference

784410
stoichiometry: 1.0
species: 044758
type: SpeciesReference

782915
stoichiometry: 1.0
species: 044782
type: SpeciesReference

045068
constant: true
value: 0.00323198
name: kA2
type: Parameter

782252
stoichiometry: 1.0
species: 044763
type: SpeciesReference

045116
constant: true
value: 3.0
name: ncg
type: Parameter

044887
kinetic law: 784302
product: 784290
reactant: 784277
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_6
type: Reaction

783844
stoichiometry: 1.0
species: 044751
type: SpeciesReference

044812
reactant: 781742
name: v_r2_3
fast: false
kinetic law: 781766
reactant: 781730
is version of: GO:0006461
notes: Rn and RK binding before phospohorylation occurs
reversible: true
product: 781754
type: Reaction

044826
name: v_r4_2
product: 782204
notes: Dissociation of Rn and RK
is version of: GO:0043241
reversible: false
fast: false
reactant: 782192
type: Reaction
product: 782216
kinetic law: 782228

783397
stoichiometry: 1.0
species: 044721
type: SpeciesReference

785051
stoichiometry: 1.0
species: 044735
type: SpeciesReference

781889
stoichiometry: 1.0
species: 044802
type: SpeciesReference

784169
stoichiometry: 1.0
species: 044766
type: SpeciesReference

784060
stoichiometry: 1.0
species: 044741
type: SpeciesReference

045125
constant: true
value: 400.0
name: eT
type: Parameter

783048
stoichiometry: 1.0
species: 044746
type: SpeciesReference

044896
product: 784629
reactant: 784605
is version of: GO:0043241
name: v_r16_6
type: Reaction
kinetic law: 784641
product: 784617
reversible: false
fast: false
notes: Rn_G_GTP dissociation to Rn and G_GTP. Here G_GTP is the Gt heterotrimer with bound GTP

782192
stoichiometry: 1.0
species: 044761
type: SpeciesReference

044807
kinetic law: 781571
product: 781559
reactant: 781547
is version of: GO:0070141
fast: false
reversible: false
name: v_r1
type: Reaction

784811
stoichiometry: 1.0
species: 044725
type: SpeciesReference

782240
stoichiometry: 1.0
species: 044770
type: SpeciesReference

044886
kinetic law: 784265
product: 784253
reactant: 784241
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_5
type: Reaction

ORG:
  orgname: EMBL-EBI
n:
  given: Vijayalakshmi
  family: Chelliah

045115
constant: true
value: 4.0
name: cGMPdark
type: Parameter

044813
kinetic law: 781817
name: v_r2_4
reactant: 781791
product: 781804
reversible: true
reactant: 781779
fast: false
type: Reaction
notes: Rn and RK binding before phospohorylation occurs
is version of: GO:0006461

044827
type: Reaction
kinetic law: 782276
fast: false
product: 782264
reversible: false
reactant: 782240
name: v_r4_3
notes: Dissociation of Rn and RK
product: 782252
is version of: GO:0043241

783892
stoichiometry: 1.0
species: 044757
type: SpeciesReference

782891
stoichiometry: 1.0
species: 044730
type: SpeciesReference

782927
stoichiometry: 1.0
species: 044717
type: SpeciesReference

782264
stoichiometry: 1.0
species: 044802
type: SpeciesReference

045128
constant: false
value: 0.0
name: background
type: Parameter

782867
stoichiometry: 1.0
species: 044773
type: SpeciesReference

782118
stoichiometry: 1.0
species: 044796
type: SpeciesReference

784871
stoichiometry: 1.0
species: 044726
type: SpeciesReference

784422
stoichiometry: 1.0
species: 044721
type: SpeciesReference

044885
kinetic law: 784229
product: 784217
reactant: 784205
notes: GTP binding to Rn_G. GTP is taken into account in the rate constant. Here G is still a heterotrimer and GTP binds to such heterotrimer_R complex
is version of: GO:0005525
fast: false
reversible: false
name: v_r15_4
type: Reaction

781877
stoichiometry: 1.0
species: 044790
type: SpeciesReference

045127
constant: true
value: 0.0238
name: ktherm
type: Parameter

044898
product: 784726
fast: false
type: Reaction
reactant: 784702
notes: PDE activation. Here we have the following assumptions on the effector 1) Each PDE subunit may bind Ga_Gtp and become active independently from the other one and with no cooperativity, 2) A PDE hetero-tetramer can hence bind up to 2 different Ga_GTP and thus it works with its in vivo kcat (the reversible reaction is assumed to be possibly present but in this model its rate is set to zero)
name: v_r18
kinetic law: 784738
reactant: 784714
reversible: true
is version of: GO:0006461

784072
stoichiometry: 1.0
species: 044742
type: SpeciesReference

044805
constant: false
has only substance units: false
in compartment: 044715
type: Species
initial concentration: 4.0
is: SBO:0000247
name: cGMP
boundary condition: false
initial amount: NaN
is version of: CHEBI:16356

782069
stoichiometry: 1.0
species: 044780
type: SpeciesReference

044825
product: 782155
name: v_r4_1
type: Reaction
reversible: false
fast: false
reactant: 782142
kinetic law: 782180
notes: Dissociation of Rn and RK
is version of: GO:0043241
product: 782168

045113
constant: true
value: 96485.3415
name: F
type: Parameter

785377
stoichiometry: 1.0
species: 044720
type: SpeciesReference

044815
reversible: true
is version of: GO:0006461
fast: false
reactant: 781841
product: 781853
type: Reaction
notes: Rn and RK binding before phospohorylation occurs
name: v_r2_5
reactant: 781829
kinetic law: 781865