803882
stoichiometry: 1.0
species: 774457
type: SpeciesReference

metaid_0000031
constant: false
value: NaN
name: Epo_medium
type: Parameter

804041
stoichiometry: 1.0
species: 774458
type: SpeciesReference

803798
exponent: 1.0
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kind: LITRE
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species: 774454
type: SpeciesReference

774466
product: 803931
product: 803919
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is: SBO:0000180
is version of: GO:0043241
type: Reaction
reversible: false
reactant: 803907
fast: false

metaid_0000028
unit: 803738
name: picomole
type: SBMLUnitsDef

774460
is: SBO:0000291
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 794453
name: dEpoi
type: Species

774480
is: SBO:0000256
constant: true
units: metaid_0000027
value: 0.0329366
type: Parameter

774484
is: SBO:0000338
constant: true
units: metaid_0000027
value: 0.0172135
type: Parameter

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is: SBO:0000180
is version of: GO:0043241
kinetic law: 804029
reversible: false
type: Reaction
fast: false
product: 804004
product: 804017
reactant: 803992

774486
is: SBO:0000256
constant: true
units: metaid_0000027
value: 0.0748267
type: Parameter

774455
is version of: P07321
is encoded by: ENSMUSG00000029711
name: Epo
has only substance units: false
initial concentration: 2030.19
is version of: K05437
boundary condition: false
constant: false
in compartment: 774453
initial amount: NaN
is: SBO:0000280
type: Species

803714
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

774465
reactant: 803858
is version of: GO:0005102
fast: false
reactant: 803870
is version of: GO:0005128
type: Reaction
kinetic law: 803894
product: 803882
reversible: false
is: SBO:0000177

774461
is: SBO:0000291
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 774453
name: dEpoe
type: Species

774481
is: SBO:0000256
constant: true
units: metaid_0000029
value: 516.0
type: Parameter

804004
stoichiometry: 1.0
species: 774455
type: SpeciesReference

774490
is: SBO:0000356
constant: true
units: metaid_0000027
value: 0.0164042
type: Parameter

803762
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

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stoichiometry: 1.0
species: 774455
type: SpeciesReference

804017
stoichiometry: 1.0
species: 774454
type: SpeciesReference

774471
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product: 804054
reactant: 804041
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is: SBO:0000179
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reversible: false
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803738
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kind: MOLE
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is: SBO:0000356
constant: true
units: metaid_0000027
value: 0.00317871
type: Parameter

metaid_0000026
unit: 803714
name: minute
type: SBMLUnitsDef

metaid_0000033
constant: false
value: NaN
name: Epo_cells
type: Parameter

803907
stoichiometry: 1.0
species: 774457
type: SpeciesReference

774487
is: SBO:0000256
constant: true
units: metaid_0000027
value: 0.00993805
type: Parameter

774454
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is: SBO:0000244
initial concentration: 516.0
in compartment: 784453
constant: false
type: Species
initial amount: NaN
is encoded by: ENSMUSG00000006235
is version of: K05079
has only substance units: false
boundary condition: false
name: EpoR

803834
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species: 774454
type: SpeciesReference

774462
kinetic law: 803822
product: 803810
is version of: GO:0032800
is: SBO:0000176
fast: false
reversible: false
type: Reaction

803955
stoichiometry: 1.0
species: 774457
type: SpeciesReference

803870
stoichiometry: 1.0
species: 774454
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794453
is version of: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

774458
name: Epo_EpoRi
has part: P14753
has part: K05437
has part: P07321
initial amount: NaN
has part: K05079
in compartment: 794453
has only substance units: false
initial concentration: 0.0
boundary condition: false
constant: false
type: Species
is: SBO:0000297

803786
exponent: -1.0
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multipler: 1.0E-12
kind: MOLE
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774468
kinetic law: 803980
product: 803967
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is version of: GO:0015031
is: SBO:0000185
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reversible: false
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species: 774461
type: SpeciesReference

774472
kinetic law: 804104
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reactant: 804079
is version of: GO:0030163
is: SBO:0000179
fast: false
reversible: false
type: Reaction

803858
stoichiometry: 1.0
species: 774455
type: SpeciesReference

774453
is version of: BTO:0000316
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: medium
type: Compartment

803931
stoichiometry: 1.0
species: 774454
type: SpeciesReference

804054
stoichiometry: 1.0
species: 774460
type: SpeciesReference

BIOMD0000000271
occurs in: http://identifiers.org/taxonomy/39107
is part of: ko04630
modified:
  W3 CDTF: Tue Jan 31 13:10:43 GMT 2012
type: SBMLModel
length unit: length
species: 774458
name: Becker2010_EpoR_CoreModel
parameter: 774490
species: 774461
parameter: metaid_0000031
parameter: metaid_0000033
units def: metaid_0000027
reaction: 774463
units def: metaid_0000030
volume units: 773761
creator:
  ORG:
    orgname: German Cancer Research Center
  n:
    given: Marcel
    family: Schilling
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
rule: metaid_0000034
parameter: 774489
parameter: 774486
is: MODEL1005260000
reaction: 774471
substance units: metaid_0000028
parameter: 774480
species: 774455
species: 774457
species: 774460
rule: metaid_0000036
units def: metaid_0000028
reaction: 774472
reaction: 774466
notes: This is the core model described in the article: Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor Verena Becker, Marcel Schilling, Julie Bachmann, Ute Baumann, Andreas Raue, Thomas Maiwald, Jens Timmer and Ursula Klingmüller; Science Published Online May 20, 2010; DOI: 10.1126/science.1184913 PMID: 20488988 Abstract: Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input, covering a broad range of ligand concentrations. This relation solely depends on EpoR turnover independent of ligand binding, suggesting an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system. SBML model exported from PottersWheel. % PottersWheel model definition file function m = BeckerSchilling2010_EpoR_CoreModel() m = pwGetEmptyModel(); %% Meta information m.ID = 'BeckerSchilling2010_EpoR_CoreModel'; m.name = 'BeckerSchilling2010_EpoR_CoreModel'; m.description = 'BeckerSchilling2010_EpoR_CoreModel'; m.authors = {'Verena Becker',' Marcel Schilling'}; m.dates = {'2010'}; m.type = 'PW-2-0-42'; %% X: Dynamic variables % m = pwAddX(m, ID, startValue, type, minValue, maxValue, unit, compartment, name, description, typeOfStartValue) m = pwAddX(m, 'EpoR' , 516, 'fix' , 0, 10000, [], 'cell', [] , [] , [] , [] , 'protein.generic'); m = pwAddX(m, 'Epo' , 2030.19, 'global', 1890, 2310, [], …
reaction: 774465
reaction: 774468
compartment: 784453
is version of: GO:0004900
parameter: 774484
created:
  W3 CDTF: Wed May 26 17:12:55 BST 2010
species: 774454
parameter: 774487
area units: metaid_0000005
parameter: 774481
parameter: 774483
occurs in: BTO:0001035
compartment: 794453
units def: metaid_0000026
time units: metaid_0000026
creator:
  ORG:
    orgname: Department of Systems Biology, Harvard Medical School, Boston, USA
  n:
    given: Verena
    family: Becker
reaction: 774469
units def: metaid_0000029
curated: true
is described by: http://identifiers.org/pubmed/20488988
is part of: ko04640
compartment: 774453
reaction: 774462

774457
type: Species
constant: false
has part: K05437
is: SBO:0000297
initial concentration: 0.0
boundary condition: false
has part: P07321
initial amount: NaN
has part: K05079
name: Epo_EpoR
in compartment: 784453
has part: P14753
has only substance units: false

774463
kinetic law: 803846
reactant: 803834
is version of: GO:0032801
is: SBO:0000179
fast: false
reversible: false
type: Reaction

803992
stoichiometry: 1.0
species: 774458
type: SpeciesReference

803750
exponent: 1.0
scale: 0
multipler: 1.0E-12
kind: MOLE
type: SBMLUnit

774483
is: SBO:0000341
constant: true
units: metaid_0000030
value: 1.0496E-4
type: Parameter

804079
stoichiometry: 1.0
species: 774458
type: SpeciesReference

803726
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

803967
stoichiometry: 1.0
species: 774458
type: SpeciesReference

784453
is version of: GO:0009986
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cellsurface
type: Compartment

803774
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit