451683
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

775612
stoichiometry: 1.0
species: 451665
type: SpeciesReference

773761
unit: 773774
name: ml
type: SBMLUnitsDef

775576
stoichiometry: 1.0
species: 451657
type: SpeciesReference

451693
kinetic law: 774208
product: 774196
reactant: 774184
is: SBO:0000397
fast: false
reversible: false
type: Reaction

775215
stoichiometry: 1.0
species: 451667
type: SpeciesReference

451673
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

774452
stoichiometry: 1.0
species: 451683
type: SpeciesReference

291545
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_pSOS
type: Parameter

774040
stoichiometry: 1.0
species: 451620
type: SpeciesReference

451663
initial amount: NaN
is version of: C00562
type: Species
boundary condition: false
is: SBO:0000252
has only substance units: false
is version of: P31938
in compartment: 451619
constant: false
initial concentration: 0.0

774404
stoichiometry: 1.0
species: 451679
type: SpeciesReference

773736
unit: 773748
name: minutes
type: SBMLUnitsDef

775552
stoichiometry: 1.0
species: 451665
type: SpeciesReference

774707
stoichiometry: 1.0
species: 451626
type: SpeciesReference

774233
stoichiometry: 1.0
species: 451671
type: SpeciesReference

451620
is version of: Q62120
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 451619
type: Species

775263
stoichiometry: 1.0
species: 451665
type: SpeciesReference

451809
is: SBO:0000036
constant: true
units: 773992
value: 0.368384
type: Parameter

775119
stoichiometry: 1.0
species: 451663
type: SpeciesReference

451835
is: SBO:0000036
constant: true
units: 773992
value: 2.44361
type: Parameter

774780
stoichiometry: 1.0
species: 451649
type: SpeciesReference

451815
is: SBO:0000036
constant: true
units: 773992
value: 0.144515
type: Parameter

451691
reversible: false
is version of: GO:0006461
reactant: 774136
fast: false
type: Reaction
modifier: 774160
product: 774148
is: SBO:0000177
is version of: GO:0051668
kinetic law: 774172

451630
is version of: Q63932
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 11.0
initial amount: NaN
in compartment: 451619
type: Species

451640
is version of: C00562
boundary condition: false
initial concentration: 0.0
is: SBO:0000252
constant: false
has version: MOD:00048
in compartment: 451619
initial amount: NaN
is version of: P14753
type: Species
has only substance units: false

774295
stoichiometry: 1.0
species: 451673
type: SpeciesReference

451829
is: SBO:0000035
constant: true
units: 773968
value: 0.0732724
type: Parameter

775311
stoichiometry: 1.0
species: 451667
type: SpeciesReference

451681
has version: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

774658
stoichiometry: 1.0
species: 451647
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

775624
stoichiometry: 1.0
species: 451634
type: SpeciesReference

451695
kinetic law: 774245
product: 774233
reactant: 774220
is: SBO:0000397
fast: false
reversible: false
type: Reaction

774744
stoichiometry: 1.0
species: 451649
type: SpeciesReference

774695
stoichiometry: 1.0
species: 451647
type: SpeciesReference

774052
stoichiometry: 1.0
species: 451638
type: SpeciesReference

451675
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

775540
stoichiometry: 1.0
species: 451655
type: SpeciesReference

451661
is version of: C00562
is: SBO:0000252
is version of: Q63932
initial amount: NaN
constant: false
in compartment: 451619
initial concentration: 0.0
type: Species
boundary condition: false
has only substance units: false

773724
exponent: 1.0
scale: 4
multipler: 1.0
kind: ITEM
type: SBMLUnit

291533
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppMEK2
type: Parameter

775010
stoichiometry: 1.0
species: 451651
type: SpeciesReference

773774
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

451807
is: SBO:0000036
constant: true
units: 773992
value: 1.19995
type: Parameter

451827
is: SBO:0000035
constant: true
units: 773968
value: 0.130937
type: Parameter

451837
is: SBO:0000036
constant: true
units: 773992
value: 53.0816
type: Parameter

451622
is version of: P14753
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 451619
type: Species

451817
is: SBO:0000035
constant: true
units: 773968
value: 0.374228
type: Parameter

451760
reversible: false
is part of: REACT 12439.1
is: SBO:0000216
product: 775552
is version of: GO:0000188
type: Reaction
kinetic law: 775564
is version of: GO:0017017
is version of: GO:0006470
reactant: 775540
fast: false

773907
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

774792
stoichiometry: 1.0
species: 451628
type: SpeciesReference

774220
stoichiometry: 1.0
species: 451669
type: SpeciesReference

774148
stoichiometry: 1.0
species: 451642
type: SpeciesReference

451642
boundary condition: false
type: Species
has property: GO:0019897
initial concentration: 0.0
initial amount: NaN
has only substance units: false
is version of: P29351
in compartment: 451619
is: SBO:0000252
constant: false

291530
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppMEK1
type: Parameter

773968
unit: 773980
name: per minute
type: SBMLUnitsDef

775022
stoichiometry: 1.0
species: 451661
type: SpeciesReference

291518
is: SBO:0000381
constant: true
units: 773919
value: 13.5981
name: scale_ppERK
type: Parameter

773712
unit: 773724
name: 10E4 molecules
type: SBMLUnitsDef

774269
stoichiometry: 1.0
species: 451673
type: SpeciesReference

451697
kinetic law: 774282
product: 774269
reactant: 774257
is: SBO:0000397
fast: false
reversible: false
type: Reaction

451748
is: SBO:0000216
modifier: 775275
reversible: false
is part of: REACT 136.4
product: 775263
is version of: GO:0004708
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2
kinetic law: 775287
reactant: 775251

773811
unit: 773834
unit: 773822
name: U_per_ml
type: SBMLUnitsDef

451758
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0000187
fast: false
product: 775504
is version of: GO:0004708
modifier: 775516
reversible: false
reactant: 775492
is: SBO:0000216
kinetic law: 775528
type: Reaction

774732
stoichiometry: 1.0
species: 451628
type: SpeciesReference

451797
is: SBO:0000036
constant: true
units: 773846
value: 0.0122149
type: Parameter

775780
stoichiometry: 1.0
species: 451659
type: SpeciesReference

451706
kinetic law: 774428
product: 774416
reactant: 774404
is: SBO:0000397
fast: false
reversible: false
type: Reaction

451645
has property: GO:0004725
is version of: P29351
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 0.0
boundary condition: false
in compartment: 451619

774477
stoichiometry: 1.0
species: 451683
type: SpeciesReference

774646
stoichiometry: 1.0
species: 451626
type: SpeciesReference

451831
is: SBO:0000036
constant: true
units: 773992
value: 2.4927
type: Parameter

451845
is: SBO:0000035
constant: true
units: 773968
value: 0.124944
type: Parameter

451686
is version of: GO:0010535
kinetic law: 774076
is homolog to: REACT 23935.1
is version of: http://identifiers.org/ec-code/2.7.10.2
modifier: 774064
is: SBO:0000216
product: 774052
reversible: false
reactant: 774040
fast: false
is version of: GO:0004715
type: Reaction

774561
stoichiometry: 1.0
species: 451622
type: SpeciesReference

774549
stoichiometry: 1.0
species: 451640
type: SpeciesReference

291527
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_pEpoR
type: Parameter

291536
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppERK1
type: Parameter

451805
is: SBO:0000035
constant: true
units: 773968
value: 0.0248773
type: Parameter

451634
is version of: Q63844
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.0
initial amount: NaN
in compartment: 451619
type: Species

451772
kinetic law: 775804
product: 775792
reactant: 775780
is version of: GO:0006470
is: SBO:0000330
fast: false
reversible: false
type: Reaction

451819
is: SBO:0000036
constant: true
units: 773992
value: 3.11919
type: Parameter

774307
stoichiometry: 1.0
species: 451675
type: SpeciesReference

451746
modifier: 775227
kinetic law: 775239
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 775215
fast: false
is version of: GO:0004708
is: SBO:0000216
reversible: false
type: Reaction
reactant: 775203

774257
stoichiometry: 1.0
species: 451671
type: SpeciesReference

451708
kinetic law: 774464
product: 774452
reactant: 774440
is: SBO:0000397
fast: false
reversible: false
type: Reaction

451685
in compartment: 451619
constant: false
is version of: P07321
has only substance units: false
initial concentration: 50.0
substance units: 773786
is: SBO:0000252
type: Species
boundary condition: false
initial amount: NaN
has property: GO:0005128

774196
stoichiometry: 1.0
species: 451669
type: SpeciesReference

775588
stoichiometry: 1.0
species: 451667
type: SpeciesReference

775648
stoichiometry: 1.0
species: 451667
type: SpeciesReference

774489
stoichiometry: 1.0
species: 451645
type: SpeciesReference

775744
stoichiometry: 1.0
species: 451659
type: SpeciesReference

775792
stoichiometry: 1.0
species: 451626
type: SpeciesReference

451647
in compartment: 451619
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has property: GO:0005085
initial concentration: 0.0
has property: GO:0019897
has only substance units: false
is version of: Q62245
boundary condition: false

451799
is: SBO:0000036
constant: true
units: 773992
value: 3.15714
type: Parameter

451718
is version of: GO:0006461
reactant: 774646
kinetic law: 774683
fast: false
is: SBO:0000177
reversible: false
modifier: 774670
type: Reaction
product: 774658

451671
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

773822
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

291515
is: SBO:0000381
constant: true
units: 773919
value: 0.21008
name: scale_pJAK2
type: Parameter

451720
kinetic law: 774720
product: 774707
reactant: 774695
is: SBO:0000180
fast: false
reversible: false
type: Reaction

451843
is: SBO:0000036
constant: true
units: 773992
value: 5122.68
type: Parameter

291548
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_SOS
type: Parameter

451833
is: SBO:0000036
constant: true
units: 773992
value: 59.5251
type: Parameter

774380
stoichiometry: 1.0
species: 451679
type: SpeciesReference

451730
reactant: 774913
kinetic law: 774949
is part of: REACT 1727.5
modifier: 774937
is version of: GO:0000186
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.25
product: 774925
is: SBO:0000216
fast: false

451770
product: 775744
is: GO:0004707
is version of: http://identifiers.org/ec-code/2.7.11.24
fast: false
is: SBO:0000216
kinetic law: 775768
reactant: 775732
is homolog to: REACT 1420.5
type: Reaction
is version of: GO:0006468
reversible: false
modifier: 775756

451803
is: SBO:0000035
constant: true
units: 773968
value: 0.408408
type: Parameter

774004
exponent: -1.0
scale: 4
multipler: 1.0
kind: ITEM
type: SBMLUnit

451632
is version of: P31938
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 24.0
initial amount: NaN
in compartment: 451619
type: Species

775299
stoichiometry: 1.0
species: 451636
type: SpeciesReference

451649
initial concentration: 0.0
constant: false
type: Species
is version of: Q99N57
has version: MOD:00046
boundary condition: false
is homolog to: REACT 3158
has property: GO:0004709
in compartment: 451619
has only substance units: false
is: SBO:0000252
initial amount: NaN
is version of: C00562

773980
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

291524
is: SBO:0000381
constant: true
units: 773919
value: 40.5364
name: scale_ppMEK
type: Parameter

451801
is: SBO:0000036
constant: true
units: 773992
value: 0.408408
type: Parameter

774016
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

451764
is version of: GO:0017017
reactant: 775612
is part of: REACT 12439.1
reversible: false
is: SBO:0000216
type: Reaction
is version of: GO:0006470
fast: false
kinetic law: 775636
product: 775624

774925
stoichiometry: 1.0
species: 451651
type: SpeciesReference

775094
stoichiometry: 1.0
species: 451630
type: SpeciesReference

775131
stoichiometry: 1.0
species: 451632
type: SpeciesReference

451821
is: SBO:0000036
constant: true
units: 773992
value: 215.158
type: Parameter

773798
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

451619
is version of: GO:0005623
is version of: FMA:83517
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

291539
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_ppERK2
type: Parameter

775347
stoichiometry: 1.0
species: 451665
type: SpeciesReference

775396
stoichiometry: 1.0
species: 451667
type: SpeciesReference

451744
modifier: 775179
reactant: 775155
kinetic law: 775191
is version of: GO:0004708
reversible: false
fast: false
is part of: REACT 136.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 775167
is: SBO:0000216

451754
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0000187
reactant: 775396
modifier: 775420
is: SBO:0000216
reversible: false
kinetic law: 775432
fast: false
type: Reaction
product: 775408
is version of: GO:0004708

773846
unit: 773882
unit: 773870
unit: 773858
name: per min per (Uml)
type: SBMLUnitsDef

451659
initial concentration: 0.0
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is version of: C00562
is version of: Q62245
constant: false
in compartment: 451619

451716
is: SBO:0000330
fast: false
reactant: 774597
product: 774610
is version of: GO:0004725
type: Reaction
modifier: 774622
is version of: http://identifiers.org/ec-code/3.1.3.48
kinetic law: 774634
reversible: false

774100
stoichiometry: 1.0
species: 451640
type: SpeciesReference

451638
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: 0.0
is homolog to: REACT_24029
boundary condition: false
is version of: C00562
is version of: Q62120
constant: false
in compartment: 451619
has version: MOD:00048
has property: GO:0004713

451702
kinetic law: 774355
product: 774343
reactant: 774331
is: SBO:0000397
fast: false
reversible: false
type: Reaction

451669
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

ORG:
  orgname: German Cancer Research Center
n:
  given: Marcel
  family: Schilling

775046
stoichiometry: 1.0
species: 451653
type: SpeciesReference

451841
is: SBO:0000035
constant: true
units: 773968
value: 3.00453
type: Parameter

451689
modifier: 774112
fast: false
is version of: GO:0004715
product: 774100
reactant: 774088
type: Reaction
reversible: false
kinetic law: 774124
is: SBO:0000216
is version of: http://identifiers.org/ec-code/2.7.10.2

451722
is: SBO:0000216
type: Reaction
product: 774744
kinetic law: 774768
modifier: 774756
is version of: GO:0000185
is version of: GO:0006468
fast: false
reversible: false
reactant: 774732

773992
unit: 774028
unit: 774016
unit: 774004
name: second order rate constant
type: SBMLUnitsDef

451679
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

451628
is version of: Q99N57
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.7719
initial amount: NaN
in compartment: 451619
type: Species

451736
type: Reaction
product: 775022
is version of: GO:0051389
is version of: GO:0006470
fast: false
kinetic law: 775034
reversible: false
is: SBO:0000330
reactant: 775010

775408
stoichiometry: 1.0
species: 451657
type: SpeciesReference

291512
is: SBO:0000381
constant: true
units: 773919
value: 0.493312
name: scale_pEpoR
type: Parameter

774028
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

775082
stoichiometry: 1.0
species: 451661
type: SpeciesReference

451762
reversible: false
is part of: REACT 12439.1
is version of: GO:0006470
kinetic law: 775600
is: SBO:0000216
product: 775588
type: Reaction
fast: false
reactant: 775576
is version of: GO:0000188
is version of: GO:0017017

BIOMD0000000270
reaction: 451766
parameter: 451813
parameter: 451829
reaction: 451714
reaction: 451695
parameter: 291542
parameter: 291548
parameter: 451801
parameter: 451797
parameter: 451827
reaction: 451750
parameter: 451835
species: 451645
reaction: 451702
reaction: 451736
time units: 773736
species: 451634
volume units: 773761
notes: This is the distributive model described the article: Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J and Klingmueller U; Mol Syst Biol. 2009;5:334. PubmedID: 20029368 ; DOI: 10.1038/msb.2009.91 Abstract: Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. By combining quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, we predicted and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. Model analysis showed bow-tie-shaped signal processing and inherently transient signalling for cytokine-induced ERK signalling. Sensitivity analysis predicted that, through a feedback-mediated process, increasing one ERK isoform reduces activation of the other isoform, which was verified by protein over-expression. We calculated ERK activation for biochemically not addressable but physiologically relevant ligand concentrations showing that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. Thus, we provide a quantitative link between earlier unobservable signalling dynamics and cell fate decisions. SBML model exported from PottersWheel on 2009-04-20 18:57:44. Below follows the source code for the model definition file in PottersWheel/Matlab: % PottersWheel model definition file function m = getModel() m = pwGetEmptyModel(); %% Meta information m.ID = 'ERK_distributive_model'; m.name = 'ERK_distributive_model'; m.description = 'ERK model calibrated to CFU-E as described in Schilling et al.'; m.authors = {'Marcel Schilling','…
reaction: 451724
species: 451659
has version: mmu04630
species: 451622
reaction: 451716
units def: 773992
parameter: 451845
parameter: 291518
parameter: 451799
parameter: 451811
reaction: 451752
compartment: 451619
parameter: 451837
reaction: 451704
species: 451677
reaction: 451693
reaction: 451740
rule: 291481
rule: 291478
species: 451683
name: Schilling2009_ERK_distributive
parameter: 291524
parameter: 451821
species: 451626
reaction: 451722
species: 451657
units def: 773895
species: 451620
parameter: 451843
units def: 773736
parameter: 291530
species: 451669
species: 451685
species: 451651
occurs in: http://identifiers.org/taxonomy/10090
reaction: 451754
species: 451681
species: 451628
parameter: 291539
reaction: 451742
length unit: length
species: 451624
reaction: 451728
rule: 291484
reaction: 451689
reaction: 451686
parameter: 451823
reaction: 451764
species: 451667
substance units: 773712
has version: GO:0000165
reaction: 451756
rule: 291480
is: MODEL1001120000
has version: GO:0004900
reaction: 451697
rule: 291489
species: 451632
reaction: 451744
reaction: 451691
reaction: 451772

451756
kinetic law: 775480
is: SBO:0000216
is version of: GO:0004708
product: 775456
reversible: false
reactant: 775444
fast: false
modifier: 775468
is part of: REACT 136.4
is version of: http://identifiers.org/ec-code/2.7.12.2
type: Reaction
is version of: GO:0000187

451742
kinetic law: 775143
product: 775131
reactant: 775119
is version of: GO:0006470
is: SBO:0000330
fast: false
reversible: false
type: Reaction

775696
stoichiometry: 1.0
species: 451659
type: SpeciesReference

773895
unit: 773907
name: arb. units
type: SBMLUnitsDef

773834
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

774525
stoichiometry: 1.0
species: 451624
type: SpeciesReference

451733
is version of: http://identifiers.org/ec-code/2.7.11.25
is version of: GO:0000186
product: 774974
reactant: 774962
kinetic law: 774998
fast: false
reversible: false
is part of: REACT 545.5
type: Reaction
modifier: 774986
is: SBO:0000216

775359
stoichiometry: 1.0
species: 451655
type: SpeciesReference

773786
unit: 773798
name: U
type: SBMLUnitsDef

775684
stoichiometry: 1.0
species: 451647
type: SpeciesReference

775732
stoichiometry: 1.0
species: 451647
type: SpeciesReference

774610
stoichiometry: 1.0
species: 451620
type: SpeciesReference

451657
has only substance units: false
has property: GO:0004707
type: Species
is: SBO:0000252
is version of: P63085
has part: MOD:00047
boundary condition: false
initial amount: NaN
is version of: C00562
has part: MOD:00048
in compartment: 451619
constant: false
initial concentration: 0.0

451714
modifier: 774573
reversible: false
is: SBO:0000330
is version of: http://identifiers.org/ec-code/3.1.3.48
reactant: 774549
kinetic law: 774585
product: 774561
type: Reaction
fast: false
is version of: GO:0004725

774184
stoichiometry: 1.0
species: 451642
type: SpeciesReference

451704
kinetic law: 774392
product: 774380
reactant: 774367
is: SBO:0000397
fast: false
reversible: false
type: Reaction

774597
stoichiometry: 1.0
species: 451638
type: SpeciesReference

451636
is version of: P63085
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 21.0
initial amount: NaN
in compartment: 451619
type: Species

451677
is version of: P29351
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
type: Species

451724
type: Reaction
is version of: GO:0006470
kinetic law: 774804
fast: false
reactant: 774780
product: 774792
reversible: false
is: SBO:0000330
is version of: GO:0051390

774343
stoichiometry: 1.0
species: 451677
type: SpeciesReference

775444
stoichiometry: 1.0
species: 451665
type: SpeciesReference

774877
stoichiometry: 1.0
species: 451663
type: SpeciesReference

773931
exponent: -1.0
scale: 4
multipler: 1.0
kind: ITEM
type: SBMLUnit

775058
stoichiometry: 1.0
species: 451663
type: SpeciesReference

774088
stoichiometry: 1.0
species: 451622
type: SpeciesReference

773944
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

774513
stoichiometry: 1.0
species: 451645
type: SpeciesReference

774136
stoichiometry: 1.0
species: 451624
type: SpeciesReference

451768
fast: false
is version of: GO:0006468
kinetic law: 775720
is version of: http://identifiers.org/ec-code/2.7.11.24
modifier: 775708
type: Reaction
is: GO:0004707
reactant: 775684
is: SBO:0000216
product: 775696
reversible: false
is homolog to: REACT 1420.5

451811
is: SBO:0000036
constant: true
units: 773992
value: 0.10271
type: Parameter

773919
unit: 773956
unit: 773944
unit: 773931
name: arb. unit. per 10000 molecules
type: SBMLUnitsDef

451750
type: Reaction
kinetic law: 775335
is version of: http://identifiers.org/ec-code/2.7.12.2
is: SBO:0000216
fast: false
is version of: GO:0004708
reactant: 775299
modifier: 775323
reversible: false
product: 775311

775155
stoichiometry: 1.0
species: 451634
type: SpeciesReference

451740
kinetic law: 775106
product: 775094
reactant: 775082
is version of: GO:0006470
is: SBO:0000330
fast: false
reversible: false
type: Reaction

451839
is: SBO:0000035
constant: true
units: 773968
value: 39.0886
type: Parameter

451825
is: SBO:0000036
constant: true
units: 773992
value: 667.957
type: Parameter

774962
stoichiometry: 1.0
species: 451663
type: SpeciesReference

775251
stoichiometry: 1.0
species: 451634
type: SpeciesReference

774416
stoichiometry: 1.0
species: 451681
type: SpeciesReference

775504
stoichiometry: 1.0
species: 451657
type: SpeciesReference

W3 CDTF: Fri Oct 29 12:55:02 BST 2010

451655
type: Species
is version of: Q63844
has part: MOD:00048
is version of: C00562
has only substance units: false
constant: false
initial concentration: 0.0
in compartment: 451619
boundary condition: false
has property: GO:0004707
is: SBO:0000252
initial amount: NaN
has part: MOD:00047

451712
kinetic law: 774537
product: 774525
reactant: 774513
is: SBO:0000396
fast: false
reversible: false
type: Reaction

451665
is version of: C00562
in compartment: 451619
initial concentration: 0.0
constant: false
boundary condition: false
type: Species
is: SBO:0000252
initial amount: NaN
is version of: Q63844
has part: MOD:00048
has only substance units: false

774865
stoichiometry: 1.0
species: 451632
type: SpeciesReference

775456
stoichiometry: 1.0
species: 451655
type: SpeciesReference

774331
stoichiometry: 1.0
species: 451675
type: SpeciesReference

773882
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

451624
type: Species
is version of: P29351
in compartment: 451619
is version of: IPR000387
constant: false
boundary condition: false
initial concentration: 10.7991
is: SBO:0000252
has only substance units: false
initial amount: NaN

774816
stoichiometry: 1.0
species: 451630
type: SpeciesReference

451726
kinetic law: 774852
type: Reaction
is version of: GO:0004709
is: SBO:0000216
reversible: false
modifier: 774840
product: 774828
reactant: 774816
is version of: http://identifiers.org/ec-code/2.7.11.25
is part of: REACT 1727.5
fast: false

773956
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

773858
exponent: -1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

291542
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_pJAK2
type: Parameter

774367
stoichiometry: 1.0
species: 451677
type: SpeciesReference

451766
kinetic law: 775672
product: 775660
fast: false
type: Reaction
is version of: GO:0006470
reactant: 775648
is part of: REACT 12439.1
is version of: GO:0017017
is: SBO:0000216
reversible: false

775492
stoichiometry: 1.0
species: 451667
type: SpeciesReference

451813
is: SBO:0000035
constant: true
units: 773968
value: 15.5956
type: Parameter

775167
stoichiometry: 1.0
species: 451665
type: SpeciesReference

774974
stoichiometry: 1.0
species: 451653
type: SpeciesReference

451752
is part of: REACT 136.4
is version of: http://identifiers.org/ec-code/2.7.12.2
reactant: 775347
is version of: GO:0000187
product: 775359
is version of: GO:0004708
reversible: false
kinetic law: 775384
is: SBO:0000216
type: Reaction
fast: false
modifier: 775371

774913
stoichiometry: 1.0
species: 451661
type: SpeciesReference

773870
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

451823
is: SBO:0000036
constant: true
units: 773992
value: 0.687193
type: Parameter

451667
has part: MOD:00048
is version of: C00562
initial concentration: 0.0
initial amount: NaN
in compartment: 451619
has only substance units: false
constant: false
is version of: P63085
type: Species
is: SBO:0000252
boundary condition: false

291521
is: SBO:0000381
constant: true
units: 773919
value: 1.10228
name: scale_SOS
type: Parameter

451700
kinetic law: 774319
product: 774307
reactant: 774295
is: SBO:0000397
fast: false
reversible: false
type: Reaction

451653
is version of: P31938
type: Species
initial amount: NaN
has only substance units: false
has part: MOD:00048
is version of: C00562
has property: GO:0004709
initial concentration: 0.0
in compartment: 451619
boundary condition: false
constant: false
has part: MOD:00047
is: SBO:0000252

451710
kinetic law: 774501
product: 774489
reactant: 774477
is: SBO:0000396
fast: false
reversible: false
type: Reaction

773748
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

451651
has version: MOD:00047
has only substance units: false
in compartment: 451619
is version of: Q63932
has property: GO:0004709
constant: false
boundary condition: false
has version: MOD:00048
initial amount: NaN
is version of: C00562
type: Species
is: SBO:0000252
initial concentration: 0.0

774440
stoichiometry: 1.0
species: 451681
type: SpeciesReference

291551
is: SBO:0000196
constant: false
units: 773895
value: NaN
name: rescaled_mSOS
type: Parameter

775660
stoichiometry: 1.0
species: 451636
type: SpeciesReference

451738
reactant: 775046
is version of: GO:0051389
reversible: false
type: Reaction
is version of: GO:0006470
kinetic law: 775070
is: SBO:0000330
fast: false
product: 775058

451626
has version: Q62245
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5101
initial amount: NaN
in compartment: 451619
type: Species

775203
stoichiometry: 1.0
species: 451636
type: SpeciesReference

774828
stoichiometry: 1.0
species: 451661
type: SpeciesReference

451728
is: SBO:0000216
is version of: GO:0004709
reversible: false
modifier: 774889
is part of: REACT 545.5
is version of: http://identifiers.org/ec-code/2.7.11.25
product: 774877
fast: false
reactant: 774865
type: Reaction
kinetic law: 774901

W3 CDTF: Wed Oct 27 17:50:24 BST 2010