703754
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

280645
constant: true
units: 703585
value: 594000.0
type: Parameter

280399
initial concentration: 185.50378543937
has only substance units: false
name: b_Cysteine
type: Species
is version of: CHEBI:15356
constant: false
in compartment: 280366
boundary condition: false
initial amount: NaN
is version of: C00736

703862
stoichiometry: 2.0
species: 280399
type: SpeciesReference

706316
stoichiometry: 1.0
species: 280409
type: SpeciesReference

704673
stoichiometry: 1.0
species: 280392
type: SpeciesReference

280385
name: c_5-methyl-THF
in compartment: 280367
type: Species
boundary condition: false
is version of: CHEBI:15641
constant: false
is version of: C00440
has only substance units: false
initial concentration: 4.4965335653401
initial amount: NaN

280731
constant: true
units: 703549
value: 1.4
type: Parameter

705833
stoichiometry: 1.0
species: 280417
type: SpeciesReference

280744
constant: true
units: 703549
value: 500.0
type: Parameter

280631
constant: true
units: 703585
value: 15000.0
type: Parameter

705677
stoichiometry: 1.0
species: 280427
type: SpeciesReference

705278
stoichiometry: 1.0
species: 280415
type: SpeciesReference

280483
is version of: R01220
reactant: 705435
reactant: 705447
modifier: 705471
reversible: true
type: Reaction
modifier: 705483
product: 705459
fast: false
kinetic law: 705495

704516
stoichiometry: 1.0
species: 280423
type: SpeciesReference

280412
is version of: http://identifiers.org/pubchem.compound/834
constant: false
boundary condition: false
has only substance units: false
initial concentration: 36.8825861752429
initial amount: NaN
in compartment: 280367
name: Cystathione
type: Species

280745
constant: true
units: 703585
value: 3600.0
type: Parameter

280697
constant: true
units: 703549
value: 50.0
type: Parameter

704323
stoichiometry: 1.0
species: 280404
type: SpeciesReference

703802
stoichiometry: 1.0
species: 280399
type: SpeciesReference

704383
stoichiometry: 1.0
species: 280371
type: SpeciesReference

280379
is version of: C00027
is version of: CHEBI:16240
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.01
initial amount: NaN
in compartment: 280367
type: Species

280401
initial concentration: 12.6996048211362
is version of: C00051
type: Species
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in compartment: 280366
is version of: CHEBI:16856
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

280632
constant: true
units: 703549
value: 50.0
type: Parameter

280759
constant: true
units: 703549
value: 22.0
type: Parameter

280484
kinetic law: 705543
product: 705531
product: 705519
reactant: 705507
is version of: R01220
fast: false
reversible: true
type: Reaction

280421
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name: m_Serine
is version of: C00716
initial concentration: 2114.87119909779
boundary condition: false
is version of: CHEBI:17822
has only substance units: false
initial amount: NaN
constant: false
type: Species

280384
has only substance units: false
initial concentration: NaN
constant: false
is version of: C00101
in compartment: 280368
boundary condition: false
name: m_THF
is version of: CHEBI:15635
initial amount: NaN
type: Species

705339
stoichiometry: 1.0
species: 280383
type: SpeciesReference

704722
stoichiometry: 1.0
species: 280425
type: SpeciesReference

703706
unit: 703730
unit: 703718
name: 1/uM
type: SBMLUnitsDef

280605
constant: true
units: 703633
value: 1.0
type: Parameter

280411
constant: false
has only substance units: false
is version of: CHEBI:16856
type: Species
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initial amount: NaN
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is version of: C00051
initial concentration: 6590.56824161192
boundary condition: false

280696
constant: true
units: 703585
value: 5300.0
type: Parameter

280404
constant: false
boundary condition: false
name: c_Glutamate
is version of: C00302
initial amount: NaN
has only substance units: false
initial concentration: 3219.39793573653
in compartment: 280367
type: Species
is version of: CHEBI:18237

280491
kinetic law: 705821
modifier: 705809
product: 705797
reactant: 705785
is version of: R00650
fast: false
reversible: true
type: Reaction

704685
stoichiometry: 1.0
species: 280380
type: SpeciesReference

280397
initial amount: NaN
type: Species
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name: b_Glutamate
initial concentration: 60.4330872702655
boundary condition: false
constant: false
is version of: C00302
is version of: CHEBI:18237
has only substance units: false

280643
constant: true
units: 703585
value: 180000.0
type: Parameter

280366
is version of: BTO:0000089
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

280376
constant: false
is version of: C00365
has only substance units: false
is version of: CHEBI:17622
in compartment: 280367
initial concentration: 20.0
type: Species
boundary condition: true
initial amount: NaN
name: dUMP

280756
constant: true
units: 703706
value: 5600.0
type: Parameter

280633
constant: true
units: 703549
value: 3400.0
type: Parameter

280387
is version of: CHEBI:1989
type: Species
initial concentration: 0.506278119133034
constant: false
in compartment: 280367
boundary condition: false
name: c_5-10-methylene-THF
initial amount: NaN
has only substance units: false
is version of: C00143

706304
stoichiometry: 1.0
species: 280379
type: SpeciesReference

703874
stoichiometry: 2.0
species: 280396
type: SpeciesReference

280481
kinetic law: 705423
product: 705411
reactant: 705399
reactant: 705387
is version of: R02101
fast: false
reversible: true
type: Reaction

280424
is version of: CHEBI:15740
constant: false
type: Species
is version of: C00058
initial concentration: 55.820116666595
name: m_Formate
in compartment: 280368
has only substance units: false
initial amount: NaN
boundary condition: false

704625
stoichiometry: 1.0
species: 280392
type: SpeciesReference

280471
kinetic law: 705000
product: 704988
reactant: 704976
fast: false
reversible: true
type: Reaction

280604
constant: true
units: 703549
value: 150.0
type: Parameter

704528
stoichiometry: 1.0
species: 280392
type: SpeciesReference

703609
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

280367
is version of: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

280396
initial concentration: 221.101111778807
has only substance units: false
boundary condition: false
initial amount: NaN
is version of: CHEBI:15428
type: Species
in compartment: 280366
name: b_Glycine
constant: false
is version of: C00037

280492
reactant: 705833
reactant: 705845
kinetic law: 705894
is version of: R00367
product: 705870
product: 705857
reversible: true
modifier: 705882
fast: false
type: Reaction

280695
constant: true
units: 703549
value: 14.0
type: Parameter

280644
constant: true
units: 703549
value: 2.0
type: Parameter

280747
constant: true
units: 703706
value: 5597.0
type: Parameter

280757
constant: true
units: 703549
value: 300.0
type: Parameter

703814
stoichiometry: 1.0
species: 280396
type: SpeciesReference

280377
has only substance units: false
is version of: CHEBI:27470
name: Folate
is version of: C00504
type: Species
boundary condition: true
initial concentration: 20.1
initial amount: NaN
constant: false
in compartment: 280369

280403
initial concentration: 0.942750394171554
in compartment: 280367
type: Species
is version of: C04677
constant: false
name: AICAR
initial amount: NaN
is version of: CHEBI:18406
boundary condition: false
has only substance units: false

704395
stoichiometry: 1.0
species: 280415
type: SpeciesReference

280423
constant: false
initial concentration: 2040.43402532595
name: m_Glycine
type: Species
in compartment: 280368
has only substance units: false
initial amount: NaN
is version of: C00037
is version of: CHEBI:15428
boundary condition: false

280472
fast: false
type: Reaction
reactant: 705012
reversible: true
kinetic law: 705072
product: 705048
modifier: 705060
reactant: 705024
product: 705036

280603
constant: true
units: 703585
value: 2700.0
type: Parameter

704710
stoichiometry: 1.0
species: 280384
type: SpeciesReference

705084
stoichiometry: 1.0
species: 280391
type: SpeciesReference

704129
stoichiometry: 1.0
species: 280411
type: SpeciesReference

280748
constant: true
units: 703549
value: 100.0
type: Parameter

280368
is version of: GO:0005739
constant: true
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

280493
kinetic law: 705930
product: 705918
reactant: 705906
is version of: R00649
fast: false
reversible: true
type: Reaction

280641
constant: true
units: 703549
value: 50.0
type: Parameter

704613
stoichiometry: 1.0
species: 280381
type: SpeciesReference

280621
constant: true
units: 703585
value: 2000.0
type: Parameter

280395
type: Species
initial amount: NaN
has only substance units: false
in compartment: 280368
is version of: CHEBI:15637
initial concentration: 15.9087989350187
constant: false
is version of: C00234
name: m_10-formyl-THF
boundary condition: false

280581
constant: true
units: 703549
value: 150.0
type: Parameter

280768
constant: true
units: 703549
value: 10.4
type: Parameter

705737
stoichiometry: 1.0
species: 280419
type: SpeciesReference

280416
constant: false
boundary condition: false
initial concentration: 19.1432773636787
type: Species
name: S-adenosylhomocysteine
is version of: CHEBI:16680
has only substance units: false
initial amount: NaN
is version of: C00021
in compartment: 280367

705133
stoichiometry: 1.0
species: 280389
type: SpeciesReference

280591
constant: true
units: 703549
value: 7100.0
type: Parameter

280381
has only substance units: false
initial amount: NaN
type: Species
name: Formaldehyde
constant: false
is version of: CHEBI:16842
in compartment: 280369
boundary condition: true
initial concentration: 500.0
is version of: C00067

706026
stoichiometry: 1.0
species: 280412
type: SpeciesReference

280693
constant: true
units: 703549
value: 6.3
type: Parameter

280749
constant: true
units: 703549
value: 1900.0
type: Parameter

280369
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

280769
constant: true
units: dimensionless
value: 3.25
type: Parameter

280580
constant: true
units: 703585
value: 150.0
type: Parameter

705591
stoichiometry: 1.0
species: 280389
type: SpeciesReference

703826
stoichiometry: 1.0
species: 280397
type: SpeciesReference

280425
type: Species
is version of: CHEBI:15611
boundary condition: false
initial amount: NaN
initial concentration: 9.16245914628594
name: Sarcosine
has only substance units: false
in compartment: 280369
is version of: C00213
constant: false

280601
constant: true
units: 703633
value: 1.0
type: Parameter

280380
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 0.0
name: CO2
is version of: C00011
is version of: CHEBI:16526
type: Species
boundary condition: true
in compartment: 280368

280415
initial amount: NaN
in compartment: 280367
constant: false
type: Species
name: c_Serine
is version of: CHEBI:17822
is version of: C00716
boundary condition: false
initial concentration: 562.834377270222
has only substance units: false

280480
kinetic law: 705375
product: 705363
reactant: 705351
reactant: 705339
fast: false
reversible: true
type: Reaction

280400
constant: false
initial amount: NaN
boundary condition: false
is version of: C00127
in compartment: 280366
name: b_GSSG
type: Species
has only substance units: false
is version of: CHEBI:17858
initial concentration: 0.484328542816829

704601
stoichiometry: 1.0
species: 280384
type: SpeciesReference

705870
stoichiometry: 1.0
species: 280425
type: SpeciesReference

706002
stoichiometry: 1.0
species: 280413
type: SpeciesReference

704661
stoichiometry: 1.0
species: 280423
type: SpeciesReference

280692
constant: true
units: 703585
value: 5000.0
type: Parameter

280495
kinetic law: 705966
product: 705954
reactant: 705942
is version of: R00192
fast: false
reversible: true
type: Reaction

280393
is version of: http://identifiers.org/pubchem.compound/644350
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.54929073348709
initial amount: NaN
in compartment: 280368
name: m_5-10-methenyl-THF
type: Species

703850
stoichiometry: 1.0
species: 280400
type: SpeciesReference

280383
is version of: CHEBI:15635
type: Species
has only substance units: false
constant: false
is version of: C00101
name: c_THF
in compartment: 280367
initial concentration: NaN
boundary condition: false
initial amount: NaN

704310
stoichiometry: 1.0
species: 280397
type: SpeciesReference

280593
constant: true
units: 703549
value: 2100.0
type: Parameter

705749
stoichiometry: 1.0
species: 280417
type: SpeciesReference

280600
constant: true
units: 703549
value: 150.0
type: Parameter

706014
stoichiometry: 1.0
species: 280415
type: SpeciesReference

280640
constant: true
units: 703549
value: 50.0
type: Parameter

280413
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.12248362561721
has only substance units: false
in compartment: 280367
name: Homocysteine
is version of: CHEBI:17230
is version of: C05330
constant: false

280427
has only substance units: false
initial amount: NaN
in compartment: 280369
is version of: CHEBI:17724
type: Species
constant: false
is version of: C01026
name: Dimethylglycine
boundary condition: false
initial concentration: 0.707382712261505

280392
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type: Species
has only substance units: false
is version of: CHEBI:1989
in compartment: 280368
is version of: C00143
initial amount: NaN
boundary condition: false
name: m_5-10-methylene-THF
constant: false

280496
kinetic law: 705990
reactant: 705978
is version of: R0006565
fast: false
reversible: true
type: Reaction

280691
constant: true
units: 703633
value: 22.0
type: Parameter

280620
constant: true
units: 703549
value: 3200.0
type: Parameter

280592
constant: true
units: 703585
value: 14950.0
type: Parameter

280575
constant: false
units: 703549
value: NaN
type: Parameter

280370
is version of: C01733
in compartment: 280366
name: b_Met
type: Species
has only substance units: false
initial concentration: NaN
is version of: CHEBI:16811
initial amount: NaN
boundary condition: true
constant: false

280711
constant: true
units: 703549
value: 100.0
type: Parameter

705242
stoichiometry: 1.0
species: 280420
type: SpeciesReference

280611
constant: true
units: 703585
value: 1050.0
type: Parameter

280764
constant: true
units: 703549
value: 0.09
type: Parameter

280449
kinetic law: 704298
product: 704286
reactant: 704274
is version of: GO:0042883
fast: false
reversible: true
type: Reaction

280625
constant: true
units: 703585
value: 6300.0
type: Parameter

280439
kinetic law: 704043
reactant: 704031
is version of: GO:0006751
fast: false
reversible: true
type: Reaction

280497
kinetic law: 706075
modifier: 706039
reversible: true
reactant: 706014
modifier: 706063
reactant: 706002
is version of: R01289
fast: false
modifier: 706051
type: Reaction
product: 706026

703621
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

280469
kinetic law: 704964
product: 704952
reactant: 704940
fast: false
reversible: true
type: Reaction

280739
constant: true
units: 703549
value: 1000.0
type: Parameter

704104
stoichiometry: 1.0
species: 280397
type: SpeciesReference

280459
kinetic law: 704589
product: 704577
reactant: 704565
reactant: 704552
is version of: R00944
fast: false
reversible: true
type: Reaction

280585
constant: true
units: 703549
value: 3000.0
type: Parameter

280639
constant: true
units: 703585
value: 15000.0
type: Parameter

280477
kinetic law: 705266
product: 705254
reactant: 705242
reactant: 705230
fast: false
reversible: true
type: Reaction

280725
constant: true
units: 703549
value: 130.0
type: Parameter

705145
stoichiometry: 1.0
species: 280383
type: SpeciesReference

280595
constant: true
units: 703585
value: 28000.0
type: Parameter

705205
stoichiometry: 1.0
species: 280383
type: SpeciesReference

280371
type: Species
has only substance units: false
is version of: C00716
initial amount: NaN
boundary condition: true
constant: false
is version of: CHEBI:17822
name: b_Ser
initial concentration: NaN
in compartment: 280366

705906
stoichiometry: 1.0
species: 280417
type: SpeciesReference

280419
type: Species
initial amount: NaN
in compartment: 280367
boundary condition: false
name: c_Methionine
is: C01733
constant: false
has only substance units: false
initial concentration: 49.18682158
is: CHEBI:16811

280765
constant: true
units: 703585
value: 892.5
type: Parameter

280779
constant: true
units: 703549
value: 150.0
type: Parameter

280612
constant: true
units: 703549
value: 20.0
type: Parameter

280660
constant: true
units: 703633
value: 100.0
type: Parameter

703935
stoichiometry: 1.0
species: 280399
type: SpeciesReference

280680
constant: true
units: 703549
value: 4.9
type: Parameter

705531
stoichiometry: 1.0
species: 280373
type: SpeciesReference

704250
stoichiometry: 1.0
species: 280400
type: SpeciesReference

280429
reactant: 703790
product: 703814
type: Reaction
product: 703802
kinetic law: 703838
fast: false
is version of: GO:0006751
reversible: true
product: 703826

280409
type: Species
name: c_GSSG
boundary condition: false
is version of: C00127
has only substance units: false
initial concentration: 61.3019611792609
is version of: CHEBI:17858
initial amount: NaN
constant: false
in compartment: 280367

280584
constant: true
units: dimensionless
value: 3.0
type: Parameter

280751
constant: true
units: 703549
value: 8200.0
type: Parameter

280724
constant: true
units: 703549
value: 63.0
type: Parameter

703633
unit: 703645
name: 1/h
type: SBMLUnitsDef

704055
stoichiometry: 1.0
species: 280399
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704201
stoichiometry: 1.0
species: 280409
type: SpeciesReference

280577
constant: false
units: 703585
value: NaN
type: Parameter

704940
stoichiometry: 3.0
species: 280424
type: SpeciesReference

705230
stoichiometry: 1.0
species: 280383
type: SpeciesReference

280499
kinetic law: 706111
product: 706099
reactant: 706087
is version of: R00894
fast: false
reversible: true
type: Reaction

280681
constant: true
units: 703549
value: 520.0
type: Parameter

704080
stoichiometry: 1.0
species: 280396
type: SpeciesReference

705954
stoichiometry: 1.0
species: 280413
type: SpeciesReference

280623
constant: true
units: 703549
value: 3.0
type: Parameter

280661
constant: true
units: 703585
value: 10000.0
type: Parameter

280437
kinetic law: 704019
reactant: 704007
is version of: GO:0006751
fast: false
reversible: true
type: Reaction

280613
constant: true
units: 703585
value: 11440.0
type: Parameter

280776
constant: false
value: NaN
name: Aminoacid_input
type: Parameter

280479
kinetic law: 705327
product: 705314
product: 705302
reactant: 705290
reactant: 705278
fast: false
reversible: true
type: Reaction

280583
constant: true
units: 703585
value: 1100.0
type: Parameter

280737
constant: true
units: 703585
value: 420000.0
type: Parameter

706220
stoichiometry: 1.0
species: 280404
type: SpeciesReference

280727
constant: true
units: 703549
value: 18.0
type: Parameter

280457
product: 704528
product: 704516
kinetic law: 704540
is version of: R00945
reversible: true
type: Reaction
fast: false
reactant: 704504
reactant: 704492

280597
constant: true
units: 703633
value: 1.0
type: Parameter

280489
kinetic law: 705773
modifier: 705761
product: 705749
reactant: 705737
is version of: R00650
fast: false
reversible: true
type: Reaction

280624
constant: true
units: 703549
value: 43.0
type: Parameter

280576
constant: false
units: 703585
value: NaN
type: Parameter

280417
is version of: C00019
has only substance units: false
name: S-adenosylmethionine
initial amount: NaN
in compartment: 280367
initial concentration: 81.1684566962769
constant: false
boundary condition: false
is version of: CHEBI:15414
type: Species

705290
stoichiometry: 1.0
species: 280383
type: SpeciesReference

280777
constant: true
units: 703549
value: 30.0
type: Parameter

280767
constant: true
units: 703549
value: 107.0
type: Parameter

280736
constant: true
units: 703549
value: 150.0
type: Parameter

704806
stoichiometry: 1.0
species: 280425
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704880
stoichiometry: 1.0
species: 280395
type: SpeciesReference

280596
constant: true
units: 703549
value: 300.0
type: Parameter

280615
constant: true
units: 703549
value: 50.0
type: Parameter

280445
kinetic law: 704189
product: 704177
reactant: 704165
is version of: GO:0034635
fast: false
reversible: true
type: Reaction

705096
stoichiometry: 1.0
species: 280373
type: SpeciesReference

280715
constant: true
units: 703549
value: 41.0
type: Parameter

280701
constant: true
units: 703585
value: 600000.0
type: Parameter

704746
stoichiometry: 1.0
species: 280423
type: SpeciesReference

705169
stoichiometry: 1.0
species: 280389
type: SpeciesReference

280760
constant: true
units: 703706
value: 30.0
type: Parameter

280629
constant: true
units: 703633
value: 20.0
type: Parameter

W3 CDTF: Tue Sep 07 17:28:04 BST 2010

280435
kinetic law: 703971
reactant: 703959
is version of: GO:0006538
fast: false
reversible: true
type: Reaction

703573
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704782
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280740
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706389
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280487
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280389
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280649
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705942
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280599
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280635
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280473
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280735
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280721
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280616
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280775
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705314
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280761
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280436
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280488
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280388
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705603
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280741
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280755
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280684
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280588
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280636
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703959
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280720
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704274
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280713
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280772
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280617
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280447
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703718
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706244
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280784
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703561
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280627
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280433
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280703
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280372
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280573
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704734
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280671
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704031
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280647
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280485
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280723
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280733
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703983
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704794
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705254
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280475
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280637
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280752
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280408
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280587
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280685
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704007
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280773
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280712
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705302
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280448
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280763
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280373
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280628
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280743
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280648
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280672
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705615
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280732
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704286
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703658
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280753
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280476
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705918
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705567
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280688
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706341
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280452
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280668
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280432
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280608
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280771
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705652
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280783
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280687
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704988
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280507
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280677
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280451
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705978
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280431
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280441
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280667
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280607
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280657
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280707
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280461
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280464
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280676
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280508
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704238
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706353
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704420
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705664
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705363
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280656
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705012
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280781
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280444
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280704
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705411
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280463
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280689
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280780
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705024
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280509
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280675
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704976
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280655
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280619
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280669
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705351
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280705
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280609
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280443
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280716
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280456
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706256
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704492
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280664
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704770
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706365
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280455
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280503
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280717
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704565
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703549
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280465
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705108
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703585
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280663
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BIOMD0000000268
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280579
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705387
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705447
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280653
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706292
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280468
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280728
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704165
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280709
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280708
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280440
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705555
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280652
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280453
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280719
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280505
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280729
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704577
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280679
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705399
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705435
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280665
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704177
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704868
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705048
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280651
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704952
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705785
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705507
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705459
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280500
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704830
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703790
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706124
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280501
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705519
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280460
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703670
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705193
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704347
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280699
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280659
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type: Parameter

280420
boundary condition: false
initial amount: NaN
is version of: C00058
in compartment: 280367
constant: false
is version of: CHEBI:15740
has only substance units: false
type: Species
name: c_formate
initial concentration: 13.0888186429922

703730
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

703886
stoichiometry: 2.0
species: 280397
type: SpeciesReference

706148
stoichiometry: 1.0
species: 280407
type: SpeciesReference

703682
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

W3 CDTF: Fri Sep 24 16:00:03 BST 2010