088094
stoichiometry: 1.0
species: 326545
type: SpeciesReference

327893
kinetic law: 097235
product: 097223
reactant: 097211
reactant: 097199
fast: false
reversible: true
name: v483 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

327771
kinetic law: 094309
product: 094297
reactant: 094285
reactant: 094273
fast: false
reversible: true
name: v422 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

087289
stoichiometry: 1.0
species: 326345
type: SpeciesReference

107690
stoichiometry: 1.0
species: 326629
type: SpeciesReference

074794
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

326637
notes: ERK#P:Pase3 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_P:Pase3
type: Species

082503
stoichiometry: 1.0
species: 326435
type: SpeciesReference

078706
stoichiometry: 1.0
species: 326231
type: SpeciesReference

326010
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1
type: Species

082358
stoichiometry: 1.0
species: 326417
type: SpeciesReference

092082
stoichiometry: 1.0
species: 326551
type: SpeciesReference

095537
stoichiometry: 1.0
species: 326527
type: SpeciesReference

089024
stoichiometry: 1.0
species: 326333
type: SpeciesReference

112951
stoichiometry: 1.0
species: 326931
type: SpeciesReference

326961
kinetic law: 075265
product: 075253
reactant: 075241
reactant: 075229
fast: false
reversible: true
name: v8 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP) k2 kd2
type: Reaction

328281
kinetic law: 105605
product: 105593
reactant: 105581
reactant: 105569
fast: false
reversible: true
name: v682 ErbB2#P + ErbB2:Inh -> ErbB2:ErbB2:Inh k103 kd103
type: Reaction

107459
stoichiometry: 1.0
species: 326797
type: SpeciesReference

090808
stoichiometry: 1.0
species: 326068
type: SpeciesReference

081427
stoichiometry: 1.0
species: 326309
type: SpeciesReference

327891
kinetic law: 097187
product: 097175
reactant: 097162
reactant: 097150
fast: false
reversible: true
name: v482 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

111468
stoichiometry: 1.0
species: 326425
type: SpeciesReference

328349
kinetic law: 107243
product: 107231
reactant: 107219
reactant: 107207
fast: false
reversible: true
name: v716 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
type: Reaction

102555
stoichiometry: 1.0
species: 326661
type: SpeciesReference

082997
stoichiometry: 1.0
species: 326449
type: SpeciesReference

102266
stoichiometry: 1.0
species: 326663
type: SpeciesReference

080704
stoichiometry: 1.0
species: 326309
type: SpeciesReference

093224
stoichiometry: 1.0
species: 326405
type: SpeciesReference

098368
stoichiometry: 1.0
species: 326599
type: SpeciesReference

109399
stoichiometry: 1.0
species: 326869
type: SpeciesReference

078935
stoichiometry: 1.0
species: 326056
type: SpeciesReference

326639
notes: (ERK#P:Pase3)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_P:Pase3)_i
type: Species

326012
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1:ATP
type: Species

093092
stoichiometry: 1.0
species: 326100
type: SpeciesReference

087530
stoichiometry: 1.0
species: 326297
type: SpeciesReference

112170
stoichiometry: 1.0
species: 325980
type: SpeciesReference

097405
stoichiometry: 1.0
species: 326571
type: SpeciesReference

082671
stoichiometry: 1.0
species: 326076
type: SpeciesReference

327801
kinetic law: 095033
product: 095021
reactant: 095009
reactant: 094997
fast: false
reversible: true
name: v437 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

096644
stoichiometry: 1.0
species: 326339
type: SpeciesReference

109387
stoichiometry: 1.0
species: 326685
type: SpeciesReference

099752
stoichiometry: 1.0
species: 326641
type: SpeciesReference

091144
stoichiometry: 1.0
species: 326189
type: SpeciesReference

111720
stoichiometry: 1.0
species: 325980
type: SpeciesReference

328287
kinetic law: 105750
product: 105738
reactant: 105726
reactant: 105714
fast: false
reversible: true
name: v685 ErbB2 + ErbB4:Inh -> ErbB4:Inh:ErbB2 k103 kd103
type: Reaction

106461
stoichiometry: 1.0
species: 326709
type: SpeciesReference

097633
stoichiometry: 1.0
species: 326589
type: SpeciesReference

328347
kinetic law: 107195
product: 107183
reactant: 107171
reactant: 107159
fast: false
reversible: true
name: v715 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
type: Reaction

326913
notes: EGF:ErbB1_h:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: EGF:ErbB1_h:Inh
type: Species

110724
stoichiometry: 1.0
species: 325912
type: SpeciesReference

085010
stoichiometry: 1.0
species: 326535
type: SpeciesReference

101881
stoichiometry: 1.0
species: 326641
type: SpeciesReference

329323
constant: true
value: 5.0
name: kd108
type: Parameter

103856
stoichiometry: 1.0
species: 326753
type: SpeciesReference

097597
stoichiometry: 1.0
species: 326585
type: SpeciesReference

076995
stoichiometry: 1.0
species: 326060
type: SpeciesReference

328359
kinetic law: 107484
product: 107472
reactant: 107459
reactant: 107447
fast: false
reversible: true
name: v721 PIP3 + PTEN -> PIP3:PTEN k109 kd109
type: Reaction

326633
notes: ERK#P#P:Pase3 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_PP:Pase3
type: Species

089873
stoichiometry: 1.0
species: 326108
type: SpeciesReference

326014
notes: 2(ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1
type: Species

095477
stoichiometry: 1.0
species: 326525
type: SpeciesReference

326965
kinetic law: 075362
product: 075350
reactant: 075337
reactant: 075325
fast: false
reversible: true
name: v10 EGF:ErbB1:ATP + ErbB3 -> EGF:ErbB1:ErbB3 k2b kd2b
type: Reaction

090554
stoichiometry: 1.0
species: 326541
type: SpeciesReference

107605
stoichiometry: 1.0
species: 326679
type: SpeciesReference

089808
stoichiometry: 1.0
species: 326547
type: SpeciesReference

328285
kinetic law: 105701
product: 105689
reactant: 105677
reactant: 105665
fast: false
reversible: true
name: v684 ErbB2:Inh + ErbB4 -> ErbB4:ErbB2:Inh k103 kd103
type: Reaction

089925
stoichiometry: 1.0
species: 326399
type: SpeciesReference

327051
kinetic law: 077466
product: 077453
reactant: 077441
reactant: 077429
fast: false
reversible: true
name: v54 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
type: Reaction

103170
stoichiometry: 1.0
species: 326693
type: SpeciesReference

327539
kinetic law: 088844
product: 088832
reactant: 088820
reactant: 088808
fast: false
reversible: true
name: v306 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

074939
stoichiometry: 1.0
species: 325916
type: SpeciesReference

328345
kinetic law: 107147
product: 107135
reactant: 107123
reactant: 107111
fast: false
reversible: true
name: v714 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
type: Reaction

110868
stoichiometry: 1.0
species: 326519
type: SpeciesReference

326911
notes: ErbB1_h:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1_h:Inh
type: Species

327473
kinetic law: 087253
product: 087241
reactant: 087229
reactant: 087217
fast: false
reversible: true
name: v273 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

328559
kinetic law: 112301
product: 112288
reactant: 112275
reactant: 112262
fast: false
reversible: true
name: v822 (ErbB1:ErbB3)#P + ATP -> (HRG:ErbB3:ErbB1):ATP k123 kd123
type: Reaction

086363
stoichiometry: 1.0
species: 326060
type: SpeciesReference

086267
stoichiometry: 1.0
species: 326379
type: SpeciesReference

329321
constant: true
value: 0.0
name: k108
type: Parameter

075701
stoichiometry: 1.0
species: 325966
type: SpeciesReference

098513
stoichiometry: 1.0
species: 326623
type: SpeciesReference

326963
kinetic law: 075313
product: 075301
reactant: 075289
reactant: 075277
fast: false
reversible: true
name: v9 EGF:ErbB1:ATP + ErbB2 -> EGF:ErbB1:ErbB2 k2b kd2b
type: Reaction

328357
kinetic law: 107435
product: 107423
reactant: 107411
reactant: 107399
fast: false
reversible: true
name: v720 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k108 kd108
type: Reaction

097259
stoichiometry: 1.0
species: 326451
type: SpeciesReference

084445
stoichiometry: 1.0
species: 326419
type: SpeciesReference

326635
notes: (ERK#P#P:Pase3)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_PP:Pase3)_i
type: Species

326016
notes: 2(ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: 2(ErbB2)_P:GAP:Grb2:Gab1:ATP
type: Species

092865
stoichiometry: 1.0
species: 326559
type: SpeciesReference

327471
kinetic law: 087205
product: 087193
reactant: 087181
reactant: 087169
fast: false
reversible: true
name: v272 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

328283
kinetic law: 105653
product: 105641
reactant: 105629
reactant: 105617
fast: false
reversible: true
name: v683 ErbB2:Inh + ErbB3 -> ErbB3:ErbB2:Inh k103 kd103
type: Reaction

091408
stoichiometry: 1.0
species: 326277
type: SpeciesReference

098597
stoichiometry: 1.0
species: 326599
type: SpeciesReference

080921
stoichiometry: 1.0
species: 326203
type: SpeciesReference

079936
stoichiometry: 1.0
species: 326309
type: SpeciesReference

103110
stoichiometry: 1.0
species: 326707
type: SpeciesReference

329327
constant: true
value: 0.1
name: kd109
type: Parameter

326917
notes: 2(EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1_h:Inh)
type: Species

113251
stoichiometry: 1.0
species: 325980
type: SpeciesReference

076681
stoichiometry: 1.0
species: 326032
type: SpeciesReference

328993
constant: true
value: 5.91474E-7
name: k8
type: Parameter

327323
kinetic law: 083648
product: 083636
reactant: 083624
reactant: 083612
fast: false
reversible: true
name: v197 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8
type: Reaction

084950
stoichiometry: 1.0
species: 326521
type: SpeciesReference

090664
stoichiometry: 1.0
species: 326407
type: SpeciesReference

326857
notes: ErbB1:ErbB:Gab1#P## , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ErbB1:ErbB:Gab1_P#
type: Species

327475
kinetic law: 087301
product: 087289
reactant: 087277
reactant: 087265
fast: false
reversible: true
name: v274 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

328343
kinetic law: 107099
product: 107087
reactant: 107074
reactant: 107062
fast: false
reversible: true
name: v713 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k107 kd107
type: Reaction

101772
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326741
notes: PIP3:AKT#P:PDK1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT_P:PDK1
type: Species

327537
kinetic law: 088796
product: 088784
reactant: 088771
reactant: 088759
fast: false
reversible: true
name: v305 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

086796
stoichiometry: 1.0
species: 326395
type: SpeciesReference

105617
stoichiometry: 1.0
species: 325968
type: SpeciesReference

103700
stoichiometry: 1.0
species: 326735
type: SpeciesReference

107714
stoichiometry: 1.0
species: 326827
type: SpeciesReference

103568
stoichiometry: 1.0
species: 326737
type: SpeciesReference

082298
stoichiometry: 1.0
species: 326309
type: SpeciesReference

096920
stoichiometry: 1.0
species: 326531
type: SpeciesReference

328405
kinetic law: 108592
product: 108580
reactant: 108568
reactant: 108556
fast: false
reversible: true
name: v744 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
type: Reaction

328053
kinetic law: 100593
product: 100581
reactant: 100569
fast: false
reversible: true
name: v566 2(ErbB2) -> R_degraded k60b kd60
type: Reaction

109014
stoichiometry: 1.0
species: 326867
type: SpeciesReference

111612
stoichiometry: 1.0
species: 326467
type: SpeciesReference

095117
stoichiometry: 1.0
species: 326321
type: SpeciesReference

328355
kinetic law: 107387
product: 107375
reactant: 107363
reactant: 107351
fast: false
reversible: true
name: v719 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
type: Reaction

111948
stoichiometry: 1.0
species: 326691
type: SpeciesReference

107942
stoichiometry: 1.0
species: 326695
type: SpeciesReference

103062
stoichiometry: 1.0
species: 326681
type: SpeciesReference

078899
stoichiometry: 1.0
species: 326247
type: SpeciesReference

329325
constant: true
value: 5.0E-6
name: k109
type: Parameter

328057
kinetic law: 100665
product: 100653
reactant: 100641
fast: false
reversible: true
name: v568 2(ErbB2)#P:GAP:Shc -> R_degraded k60b kd60
type: Reaction

326855
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P
type: Species

083829
stoichiometry: 1.0
species: 326505
type: SpeciesReference

328991
constant: false
value: 5.0E-5
name: kd6
type: Parameter

327535
kinetic law: 088747
product: 088735
reactant: 088723
reactant: 088711
fast: false
reversible: true
name: v304 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

091360
stoichiometry: 1.0
species: 326359
type: SpeciesReference

327477
kinetic law: 087349
product: 087337
reactant: 087325
reactant: 087313
fast: false
reversible: true
name: v275 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

098717
stoichiometry: 1.0
species: 326625
type: SpeciesReference

327321
kinetic law: 083600
product: 083588
reactant: 083576
reactant: 083564
fast: false
reversible: true
name: v196 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
type: Reaction

086472
stoichiometry: 1.0
species: 326417
type: SpeciesReference

326915
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)
type: Species

098669
stoichiometry: 1.0
species: 326619
type: SpeciesReference

326743
notes: PIP3:AKT:PDK1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT:PDK1
type: Species

079382
stoichiometry: 1.0
species: 326287
type: SpeciesReference

106966
stoichiometry: 1.0
species: 326805
type: SpeciesReference

328341
kinetic law: 107050
product: 107039
reactant: 107027
reactant: 107015
fast: false
reversible: true
name: v712 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
type: Reaction

097741
stoichiometry: 1.0
species: 326573
type: SpeciesReference

077297
stoichiometry: 1.0
species: 326056
type: SpeciesReference

091216
stoichiometry: 1.0
species: 326209
type: SpeciesReference

328055
kinetic law: 100629
product: 100617
reactant: 100605
fast: false
reversible: true
name: v567 2(ErbB2)#P:GAP -> R_degraded k60b kd60
type: Reaction

112236
stoichiometry: 1.0
species: 326028
type: SpeciesReference

076571
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326631
constant: false
is version of: Q16828
type: Species
has only substance units: true
in compartment: 325908
boundary condition: false
initial amount: 16870.2
notes: Pase3 , cytoplasm
name: Pase3
initial concentration: NaN

085338
stoichiometry: 1.0
species: 326521
type: SpeciesReference

328353
kinetic law: 107339
product: 107327
reactant: 107315
reactant: 107303
fast: false
reversible: true
name: v718 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
type: Reaction

087048
stoichiometry: 1.0
species: 326373
type: SpeciesReference

087410
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328403
kinetic law: 108544
product: 108532
reactant: 108520
reactant: 108508
fast: false
reversible: true
name: v743 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
type: Reaction

104604
stoichiometry: 1.0
species: 326755
type: SpeciesReference

328351
kinetic law: 107291
product: 107279
reactant: 107267
reactant: 107255
fast: false
reversible: true
name: v717 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
type: Reaction

101013
stoichiometry: 1.0
species: 326641
type: SpeciesReference

078406
stoichiometry: 1.0
species: 326056
type: SpeciesReference

092190
stoichiometry: 1.0
species: 326481
type: SpeciesReference

100064
stoichiometry: 1.0
species: 326385
type: SpeciesReference

326853
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P
type: Species

077889
stoichiometry: 1.0
species: 326134
type: SpeciesReference

326745
notes: PIP3:PDK1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:PDK1
type: Species

327533
kinetic law: 088698
product: 088686
reactant: 088674
reactant: 088662
fast: false
reversible: true
name: v303 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

327479
kinetic law: 087398
product: 087385
reactant: 087373
reactant: 087361
fast: false
reversible: true
name: v276 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

327199
kinetic law: 081029
product: 081017
reactant: 081005
reactant: 080993
fast: false
reversible: true
name: v134 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

105738
stoichiometry: 1.0
species: 326789
type: SpeciesReference

109952
stoichiometry: 1.0
species: 326853
type: SpeciesReference

107568
stoichiometry: 1.0
species: 326821
type: SpeciesReference

109807
stoichiometry: 1.0
species: 326859
type: SpeciesReference

088276
stoichiometry: 1.0
species: 326100
type: SpeciesReference

109231
stoichiometry: 1.0
species: 326543
type: SpeciesReference

082201
stoichiometry: 1.0
species: 326309
type: SpeciesReference

328409
kinetic law: 108688
product: 108676
reactant: 108664
reactant: 108652
fast: false
reversible: true
name: v746 (ERK#P#P)_i + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
type: Reaction

086159
stoichiometry: 1.0
species: 326539
type: SpeciesReference

083588
stoichiometry: 1.0
species: 326499
type: SpeciesReference

327663
kinetic law: 091878
product: 091866
reactant: 091854
reactant: 091842
fast: false
reversible: true
name: v368 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22
type: Reaction

326919
notes: ErbB1_h:ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1_h:ATP
type: Species

081537
stoichiometry: 1.0
species: 326389
type: SpeciesReference

077985
stoichiometry: 1.0
species: 326142
type: SpeciesReference

082888
stoichiometry: 1.0
species: 325946
type: SpeciesReference

329329
notes: %ERK inhibiert AKT
constant: true
value: 3.33E-4
name: k110
type: Parameter

326851
notes: 2(ErbB2)2:Gab1#P## , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)2:Gab1_P#
type: Species

327531
kinetic law: 088650
product: 088638
reactant: 088626
reactant: 088614
fast: false
reversible: true
name: v302 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326747
notes: AKT:P:P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P
type: Species

079189
stoichiometry: 1.0
species: 326271
type: SpeciesReference

109098
stoichiometry: 1.0
species: 326697
type: SpeciesReference

093332
stoichiometry: 1.0
species: 326395
type: SpeciesReference

102110
stoichiometry: 1.0
species: 326421
type: SpeciesReference

089508
stoichiometry: 1.0
species: 326359
type: SpeciesReference

082780
stoichiometry: 1.0
species: 326054
type: SpeciesReference

327661
kinetic law: 091830
product: 091818
reactant: 091806
reactant: 091794
fast: false
reversible: true
name: v367 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22
type: Reaction

328407
kinetic law: 108640
product: 108628
reactant: 108616
reactant: 108604
fast: false
reversible: true
name: v745 ERK#P#P + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
type: Reaction

091072
stoichiometry: 1.0
species: 326395
type: SpeciesReference

328051
kinetic law: 100557
product: 100545
reactant: 100533
fast: false
reversible: true
name: v565 (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
type: Reaction

075423
stoichiometry: 1.0
species: 325934
type: SpeciesReference

329291
constant: true
value: 0.03
name: kd101
type: Parameter

327993
kinetic law: 099512
product: 099500
reactant: 099488
fast: false
reversible: true
name: v533 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60 kd60
type: Reaction

327655
kinetic law: 091686
product: 091674
reactant: 091662
reactant: 091650
fast: false
reversible: true
name: v364 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

086832
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328137
kinetic law: 102134
product: 102122
reactant: 102110
reactant: 102098
fast: false
reversible: true
name: v610 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
type: Reaction

326537
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P)
type: Species

105097
stoichiometry: 1.0
species: 326413
type: SpeciesReference

099103
stoichiometry: 1.0
species: 326639
type: SpeciesReference

328561
kinetic law: 112353
product: 112340
reactant: 112327
reactant: 112314
fast: false
reversible: true
name: v823 (ErbB1:ErbB4)#P + ATP -> (HRG:ErbB4:ErbB1):ATP k123 kd123
type: Reaction

103640
stoichiometry: 1.0
species: 326739
type: SpeciesReference

327195
kinetic law: 080933
product: 080921
reactant: 080909
reactant: 080896
fast: false
reversible: true
name: v130 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b
type: Reaction

094719
stoichiometry: 1.0
species: 326577
type: SpeciesReference

085543
stoichiometry: 1.0
species: 326521
type: SpeciesReference

329215
constant: true
value: 0.0
name: k75
type: Parameter

076463
stoichiometry: 1.0
species: 326014
type: SpeciesReference

327257
kinetic law: 082406
product: 082394
reactant: 082382
fast: false
reversible: true
name: v164 ErbB1:ATP -> ErbB1:ATP k6 kd6
type: Reaction

327541
kinetic law: 088892
product: 088880
reactant: 088868
reactant: 088856
fast: false
reversible: true
name: v307 Ras:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326749
initial concentration: NaN
type: Species
initial amount: 450000.0
boundary condition: false
is version of: Q13115
has only substance units: true
constant: false
notes: Pase4 , cytoplasm
name: Pase4
in compartment: 325908

326303
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

326289
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos
type: Species

329187
notes: %PIP3 dissociates from PI3K
constant: true
value: 20.5
name: kd68b
type: Parameter

110351
stoichiometry: 1.0
species: 326895
type: SpeciesReference

106027
stoichiometry: 1.0
species: 326010
type: SpeciesReference

101543
stoichiometry: 1.0
species: 326317
type: SpeciesReference

327911
kinetic law: 097669
product: 097657
reactant: 097645
reactant: 097633
fast: false
reversible: true
name: v492 MEK + (Raf#P)_i -> (MEK:Raf#P)_i k44 kd52
type: Reaction

327319
kinetic law: 083552
product: 083540
reactant: 083528
reactant: 083516
fast: false
reversible: true
name: v195 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
type: Reaction

328989
notes: %Bart2003
constant: false
value: 0.013
name: k6
type: Parameter

326425
notes: 2(EGF:ErbB1)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P
type: Species

329109
constant: true
value: 0.01833
name: kd44
type: Parameter

103796
stoichiometry: 1.0
species: 326749
type: SpeciesReference

080176
stoichiometry: 1.0
species: 326309
type: SpeciesReference

102194
stoichiometry: 1.0
species: 326629
type: SpeciesReference

094381
stoichiometry: 1.0
species: 326575
type: SpeciesReference

104725
stoichiometry: 1.0
species: 326473
type: SpeciesReference

326393
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

110640
stoichiometry: 1.0
species: 326046
type: SpeciesReference

327991
kinetic law: 099476
product: 099464
reactant: 099452
fast: false
reversible: true
name: v532 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> R_degraded k60 kd60
type: Reaction

327653
kinetic law: 091638
product: 091626
reactant: 091613
reactant: 091601
fast: false
reversible: true
name: v363 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

085748
stoichiometry: 1.0
species: 326321
type: SpeciesReference

326395
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos
type: Species

329293
constant: true
value: 5.0E-7
name: k102
type: Parameter

102894
stoichiometry: 1.0
species: 326701
type: SpeciesReference

080284
stoichiometry: 1.0
species: 326337
type: SpeciesReference

087181
stoichiometry: 1.0
species: 326355
type: SpeciesReference

094237
stoichiometry: 1.0
species: 326575
type: SpeciesReference

329077
constant: true
value: 0.03
name: kd34
type: Parameter

326535
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P)
type: Species

328135
kinetic law: 102086
product: 102074
reactant: 102062
reactant: 102050
fast: false
reversible: true
name: v609 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
type: Reaction

112027
stoichiometry: 1.0
species: 326012
type: SpeciesReference

095333
stoichiometry: 1.0
species: 326523
type: SpeciesReference

081913
stoichiometry: 1.0
species: 326309
type: SpeciesReference

113023
stoichiometry: 1.0
species: 326943
type: SpeciesReference

112626
stoichiometry: 1.0
species: 325980
type: SpeciesReference

084168
stoichiometry: 1.0
species: 325934
type: SpeciesReference

081877
stoichiometry: 1.0
species: 326403
type: SpeciesReference

329213
notes: % determines sharpness of AKT peak
constant: false
value: 0.00633957
name: kd75
type: Parameter

327197
kinetic law: 080981
product: 080969
reactant: 080957
reactant: 080945
fast: false
reversible: true
name: v133 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

087866
stoichiometry: 1.0
species: 326315
type: SpeciesReference

329189
constant: true
value: 3.33E-5
name: k69
type: Parameter

093452
stoichiometry: 1.0
species: 326539
type: SpeciesReference

326301
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

098175
stoichiometry: 1.0
species: 326603
type: SpeciesReference

079225
stoichiometry: 1.0
species: 326056
type: SpeciesReference

328987
constant: true
value: 0.162
name: kd5c
type: Parameter

326423
notes: ErbB1:ATP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB1:ATP
type: Species

110291
stoichiometry: 1.0
species: 326683
type: SpeciesReference

085699
stoichiometry: 1.0
species: 326285
type: SpeciesReference

081113
stoichiometry: 1.0
species: 326158
type: SpeciesReference

327259
kinetic law: 082443
product: 082431
reactant: 082419
fast: false
reversible: true
name: v165 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P k6 kd6
type: Reaction

078346
stoichiometry: 1.0
species: 326201
type: SpeciesReference

079864
stoichiometry: 1.0
species: 326291
type: SpeciesReference

327913
kinetic law: 097717
product: 097705
reactant: 097693
reactant: 097681
fast: false
reversible: true
name: v493 MEK + Raf#P -> MEK:Raf#P k44 kd52
type: Reaction

088348
stoichiometry: 1.0
species: 326116
type: SpeciesReference

327317
kinetic law: 083504
product: 083492
reactant: 083480
reactant: 083468
fast: false
reversible: true
name: v194 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8b kd8b
type: Reaction

085482
stoichiometry: 1.0
species: 326507
type: SpeciesReference

329079
constant: true
value: 7.5E-6
name: k34
type: Parameter

075649
stoichiometry: 1.0
species: 325964
type: SpeciesReference

105352
stoichiometry: 1.0
species: 325998
type: SpeciesReference

329107
constant: true
value: 0.0
name: k43
type: Parameter

109735
stoichiometry: 1.0
species: 326879
type: SpeciesReference

110568
stoichiometry: 1.0
species: 326903
type: SpeciesReference

327659
kinetic law: 091782
product: 091770
reactant: 091758
reactant: 091746
fast: false
reversible: true
name: v366 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

100760
stoichiometry: 1.0
species: 326641
type: SpeciesReference

111072
stoichiometry: 1.0
species: 326915
type: SpeciesReference

328133
kinetic law: 102037
product: 102025
reactant: 102013
fast: false
reversible: true
name: v608 (ErbB4:ErbB2) -> R_degraded k62b kd60b
type: Reaction

097946
stoichiometry: 1.0
species: 326587
type: SpeciesReference

328413
kinetic law: 108784
product: 108772
reactant: 108760
reactant: 108748
fast: false
reversible: true
name: v748 (ERK#P#P)_i + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k111 kd111
type: Reaction

078550
stoichiometry: 1.0
species: 326056
type: SpeciesReference

094009
stoichiometry: 1.0
species: 326104
type: SpeciesReference

327997
kinetic law: 099584
product: 099572
reactant: 099560
fast: false
reversible: true
name: v535 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + -> R_degraded k60 kd60
type: Reaction

329211
constant: false
value: 0.355656
name: kd74
type: Parameter

327191
kinetic law: 080836
product: 080824
reactant: 080812
reactant: 080800
fast: false
reversible: true
name: v128 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k5 kd5b
type: Reaction

101809
stoichiometry: 1.0
species: 326641
type: SpeciesReference

093116
stoichiometry: 1.0
species: 326539
type: SpeciesReference

111240
stoichiometry: 1.0
species: 326515
type: SpeciesReference

327915
kinetic law: 097766
product: 097753
reactant: 097741
reactant: 097729
fast: false
reversible: true
name: v494 MEK#P + Raf#P -> MEK#P:Raf#P k44 kd52
type: Reaction

088662
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327315
kinetic law: 083455
product: 083443
reactant: 083431
fast: false
reversible: true
name: v193 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k7 kd7
type: Reaction

326421
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos
type: Species

328985
constant: true
value: 0.0080833
name: kd5b
type: Parameter

104096
stoichiometry: 1.0
species: 326759
type: SpeciesReference

328059
kinetic law: 100701
product: 100689
reactant: 100677
fast: false
reversible: true
name: v569 2(ErbB2)#P:GAP:(Shc#P) -> R_degraded k60b kd60
type: Reaction

105955
stoichiometry: 1.0
species: 326140
type: SpeciesReference

099824
stoichiometry: 1.0
species: 326641
type: SpeciesReference

076127
stoichiometry: 1.0
species: 325940
type: SpeciesReference

097886
stoichiometry: 1.0
species: 326573
type: SpeciesReference

328411
kinetic law: 108736
product: 108724
reactant: 108712
reactant: 108700
fast: false
reversible: true
name: v747 ERK#P#P + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k111 kd111
type: Reaction

090700
stoichiometry: 1.0
species: 326541
type: SpeciesReference

327657
kinetic law: 091734
product: 091722
reactant: 091710
reactant: 091698
fast: false
reversible: true
name: v365 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

096138
stoichiometry: 1.0
species: 326483
type: SpeciesReference

326539
initial concentration: NaN
is version of: Q07889
notes: Sos , cytoplasm
has only substance units: true
is described by: http://identifiers.org/omim/182530
in compartment: 325908
constant: false
initial amount: 0.0
type: Species
boundary condition: false
name: Sos

075494
stoichiometry: 1.0
species: 325956
type: SpeciesReference

106304
stoichiometry: 1.0
species: 326693
type: SpeciesReference

101434
stoichiometry: 1.0
species: 326319
type: SpeciesReference

327995
kinetic law: 099548
product: 099536
reactant: 099524
fast: false
reversible: true
name: v534 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60
type: Reaction

327193
kinetic law: 080884
product: 080872
reactant: 080860
reactant: 080848
fast: false
reversible: true
name: v129 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k5 kd5b
type: Reaction

083251
stoichiometry: 1.0
species: 326473
type: SpeciesReference

106172
stoichiometry: 1.0
species: 326022
type: SpeciesReference

084023
stoichiometry: 1.0
species: 326513
type: SpeciesReference

095057
stoichiometry: 1.0
species: 326577
type: SpeciesReference

108724
stoichiometry: 1.0
species: 326821
type: SpeciesReference

113108
stoichiometry: 1.0
species: 325980
type: SpeciesReference

327769
kinetic law: 094261
product: 094249
reactant: 094237
reactant: 094225
fast: false
reversible: true
name: v421 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

327917
kinetic law: 097814
product: 097802
reactant: 097790
reactant: 097778
fast: false
reversible: true
name: v495 MEK#P + Raf#P -> MEK:Raf#P k45 kd45
type: Reaction

328983
constant: true
value: 0.0
name: k5b
type: Parameter

090904
stoichiometry: 1.0
species: 326128
type: SpeciesReference

326859
notes: 2(EGF:ErbB1):Gab1#P## , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1):Gab1_P#
type: Species

098067
stoichiometry: 1.0
species: 326595
type: SpeciesReference

084734
stoichiometry: 1.0
species: 326379
type: SpeciesReference

101700
stoichiometry: 1.0
species: 326645
type: SpeciesReference

327313
kinetic law: 083419
product: 083407
reactant: 083395
fast: false
reversible: true
name: v192 2(ErbB2)#P:GAP:Shc -> 2(ErbB2)#P:GAP:Shc k7 kd7
type: Reaction

077043
stoichiometry: 1.0
species: 326064
type: SpeciesReference

109663
stoichiometry: 1.0
species: 326881
type: SpeciesReference

326391
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

107255
stoichiometry: 1.0
species: 326805
type: SpeciesReference

088904
stoichiometry: 1.0
species: 326545
type: SpeciesReference

108146
stoichiometry: 1.0
species: 326845
type: SpeciesReference

328131
kinetic law: 102001
product: 101989
reactant: 101977
fast: false
reversible: true
name: v607 (ErbB3:ErbB2) -> R_degraded k62b kd60b
type: Reaction

091420
stoichiometry: 1.0
species: 326541
type: SpeciesReference

080416
stoichiometry: 1.0
species: 326309
type: SpeciesReference

325948
has part: P00533
initial amount: 0.0
type: Species
initial concentration: NaN
constant: false
notes: EGF:ErbB1:ErbB4 , plasma membrane
name: EGF:ErbB1:ErbB4
has only substance units: true
has version: P01133
boundary condition: false
in compartment: 325898

107798
stoichiometry: 1.0
species: 326691
type: SpeciesReference

104460
stoichiometry: 1.0
species: 326755
type: SpeciesReference

096584
stoichiometry: 1.0
species: 326525
type: SpeciesReference

084385
stoichiometry: 1.0
species: 326437
type: SpeciesReference

081209
stoichiometry: 1.0
species: 326150
type: SpeciesReference

080524
stoichiometry: 1.0
species: 326347
type: SpeciesReference

084626
stoichiometry: 1.0
species: 326505
type: SpeciesReference

075000
stoichiometry: 1.0
species: 325910
type: SpeciesReference

326969
kinetic law: 075458
product: 075446
reactant: 075435
reactant: 075423
fast: false
reversible: true
name: v12 EGF:ErbB1:ATP + ErbB2 -> (EGF:ErbB1:ErbB2) k2b kd2b
type: Reaction

326006
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1
type: Species

327807
kinetic law: 095177
product: 095165
reactant: 095153
reactant: 095141
fast: false
reversible: true
name: v440 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

329071
constant: true
value: 4.0E-7
name: k32
type: Parameter

087938
stoichiometry: 1.0
species: 326545
type: SpeciesReference

096428
stoichiometry: 1.0
species: 326513
type: SpeciesReference

101917
stoichiometry: 1.0
species: 326641
type: SpeciesReference

096572
stoichiometry: 1.0
species: 326509
type: SpeciesReference

108616
stoichiometry: 1.0
species: 326857
type: SpeciesReference

090324
stoichiometry: 1.0
species: 326311
type: SpeciesReference

325946
notes: ErbB4 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 794.0
in compartment: 325898
name: ErbB4
type: Species

081769
stoichiometry: 1.0
species: 326309
type: SpeciesReference

090264
stoichiometry: 1.0
species: 326547
type: SpeciesReference

327919
kinetic law: 097862
product: 097850
reactant: 097838
reactant: 097826
fast: false
reversible: true
name: v496 (MEK#P)_i + (Raf#P)_i -> (MEK:Raf#P)_i k45 kd45
type: Reaction

094948
stoichiometry: 1.0
species: 326481
type: SpeciesReference

329101
constant: true
value: 6.0E-5
name: k42
type: Parameter

090119
stoichiometry: 1.0
species: 326355
type: SpeciesReference

081053
stoichiometry: 1.0
species: 326369
type: SpeciesReference

085966
stoichiometry: 1.0
species: 326539
type: SpeciesReference

080392
stoichiometry: 1.0
species: 326247
type: SpeciesReference

082575
stoichiometry: 1.0
species: 326421
type: SpeciesReference

327767
kinetic law: 094213
product: 094201
reactant: 094189
reactant: 094177
fast: false
reversible: true
name: v420 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

095609
stoichiometry: 1.0
species: 326505
type: SpeciesReference

327057
kinetic law: 077611
product: 077599
reactant: 077587
reactant: 077574
fast: false
reversible: true
name: v57 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
type: Reaction

327889
kinetic law: 097138
product: 097126
reactant: 097113
reactant: 097101
fast: false
reversible: true
name: v481 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

328569
kinetic law: 112552
product: 112540
reactant: 112528
reactant: 112516
fast: false
reversible: true
name: v827 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2):ATP k123 kd123
type: Reaction

327809
kinetic law: 095225
product: 095213
reactant: 095201
reactant: 095189
fast: false
reversible: true
name: v441 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

086039
stoichiometry: 1.0
species: 326060
type: SpeciesReference

085266
stoichiometry: 1.0
species: 326349
type: SpeciesReference

327053
kinetic law: 077514
product: 077502
reactant: 077490
reactant: 077478
fast: false
reversible: true
name: v55 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
type: Reaction

326281
notes: (ErbB4:ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2
type: Species

092949
stoichiometry: 1.0
species: 326537
type: SpeciesReference

107363
stoichiometry: 1.0
species: 326022
type: SpeciesReference

104000
stoichiometry: 1.0
species: 326745
type: SpeciesReference

089443
stoichiometry: 1.0
species: 326549
type: SpeciesReference

095753
stoichiometry: 1.0
species: 326499
type: SpeciesReference

326967
kinetic law: 075411
product: 075399
reactant: 075386
reactant: 075374
fast: false
reversible: true
name: v11 ErbB4 + EGF:ErbB1:ATP -> EGF:ErbB1:ErbB4 k2b kd2b
type: Reaction

100965
stoichiometry: 1.0
species: 326443
type: SpeciesReference

327999
kinetic law: 099620
product: 099608
reactant: 099596
fast: false
reversible: true
name: v537 ErbB3 -> R_degraded k60b kd60b
type: Reaction

110086
stoichiometry: 1.0
species: 326885
type: SpeciesReference

077249
stoichiometry: 1.0
species: 326056
type: SpeciesReference

100653
stoichiometry: 1.0
species: 326641
type: SpeciesReference

076911
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326008
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1:ATP
type: Species

325944
initial concentration: NaN
in compartment: 325898
has part: P00533
has version: P01133
has only substance units: true
notes: EGF:ErbB1:ErbB3 , plasma membrane
name: EGF:ErbB1:ErbB3
boundary condition: false
type: Species
constant: false
initial amount: 0.0

091577
stoichiometry: 1.0
species: 326329
type: SpeciesReference

086640
stoichiometry: 1.0
species: 326541
type: SpeciesReference

103495
stoichiometry: 1.0
species: 326707
type: SpeciesReference

091854
stoichiometry: 1.0
species: 326431
type: SpeciesReference

092202
stoichiometry: 1.0
species: 326485
type: SpeciesReference

327765
kinetic law: 094165
product: 094153
reactant: 094141
reactant: 094129
fast: false
reversible: true
name: v419 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

101326
stoichiometry: 1.0
species: 326323
type: SpeciesReference

329181
constant: true
value: 0.02
name: kd67
type: Parameter

075571
stoichiometry: 1.0
species: 325926
type: SpeciesReference

327887
kinetic law: 097089
product: 097077
reactant: 097065
reactant: 097053
fast: false
reversible: true
name: v480 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

328289
kinetic law: 105798
product: 105786
reactant: 105774
reactant: 105762
fast: false
reversible: true
name: v686 Shp + PIP2 -> PIP3:Shp k104 kd104
type: Reaction

328567
kinetic law: 112504
product: 112492
reactant: 112479
reactant: 112466
fast: false
reversible: true
name: v826 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2):ATP k123 kd123
type: Reaction

326309
notes: cPP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: cPP
type: Species

327055
kinetic law: 077562
product: 077550
reactant: 077538
reactant: 077526
fast: false
reversible: true
name: v56 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
type: Reaction

076235
stoichiometry: 1.0
species: 325980
type: SpeciesReference

089241
stoichiometry: 1.0
species: 326201
type: SpeciesReference

327251
kinetic law: 082286
product: 082274
reactant: 082262
reactant: 082250
fast: false
reversible: true
name: v161 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k5 kd5
type: Reaction

103411
stoichiometry: 1.0
species: 326725
type: SpeciesReference

326283
notes: (ErbB4:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:cPP
type: Species

329219
constant: true
value: 142.262
name: kd76
type: Parameter

099212
stoichiometry: 1.0
species: 326641
type: SpeciesReference

108086
stoichiometry: 1.0
species: 326699
type: SpeciesReference

327803
kinetic law: 095081
product: 095069
reactant: 095057
reactant: 095045
fast: false
reversible: true
name: v438 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

089391
stoichiometry: 1.0
species: 326549
type: SpeciesReference

329075
constant: true
value: 3.5E-5
name: k33
type: Parameter

090880
stoichiometry: 1.0
species: 326104
type: SpeciesReference

326397
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos
type: Species

075097
stoichiometry: 1.0
species: 325926
type: SpeciesReference

076091
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326533
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P)
type: Species

329295
constant: true
value: 5.61009
name: kd102
type: Parameter

079660
stoichiometry: 1.0
species: 326311
type: SpeciesReference

108942
stoichiometry: 1.0
species: 326541
type: SpeciesReference

329105
constant: true
value: 31.6228
name: kd43
type: Parameter

075229
stoichiometry: 1.0
species: 325934
type: SpeciesReference

097489
stoichiometry: 1.0
species: 326565
type: SpeciesReference

325942
notes: ErbB3 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 6230.0
in compartment: 325898
name: ErbB3
type: Species

109303
stoichiometry: 1.0
species: 326865
type: SpeciesReference

096246
stoichiometry: 1.0
species: 326525
type: SpeciesReference

326429
notes: 2(EGF:ErbB1)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP
type: Species

105146
stoichiometry: 1.0
species: 326777
type: SpeciesReference

326307
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

328565
kinetic law: 112454
product: 112442
reactant: 112429
reactant: 112416
fast: false
reversible: true
name: v825 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2:ATP k123 kd123
type: Reaction

076777
stoichiometry: 1.0
species: 326040
type: SpeciesReference

327885
kinetic law: 097041
product: 097029
reactant: 097017
reactant: 097005
fast: false
reversible: true
name: v479 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

107039
stoichiometry: 1.0
species: 326817
type: SpeciesReference

329183
notes: %PIP3 dissociates from PI3K
constant: true
value: 0.2
name: kd68
type: Parameter

326285
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos
type: Species

327763
kinetic law: 094117
product: 094105
reactant: 094093
reactant: 094081
fast: false
reversible: true
name: v418 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

327253
kinetic law: 082334
product: 082322
reactant: 082310
reactant: 082298
fast: false
reversible: true
name: v162 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k5 kd5
type: Reaction

108412
stoichiometry: 1.0
species: 326627
type: SpeciesReference

329217
constant: true
value: 0.0
name: k76
type: Parameter

104953
stoichiometry: 1.0
species: 326054
type: SpeciesReference

093669
stoichiometry: 1.0
species: 326567
type: SpeciesReference

094489
stoichiometry: 1.0
species: 326337
type: SpeciesReference

328139
kinetic law: 102182
product: 102170
reactant: 102158
reactant: 102146
fast: false
reversible: true
name: v611 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k64 kd64
type: Reaction

329073
constant: true
value: 0.2
name: kd33
type: Parameter

110243
stoichiometry: 1.0
species: 326691
type: SpeciesReference

327805
kinetic law: 095129
product: 095117
reactant: 095105
reactant: 095093
fast: false
reversible: true
name: v439 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

106244
stoichiometry: 1.0
species: 326793
type: SpeciesReference

101651
stoichiometry: 1.0
species: 326311
type: SpeciesReference

093560
stoichiometry: 1.0
species: 326245
type: SpeciesReference

110183
stoichiometry: 1.0
species: 326885
type: SpeciesReference

329297
notes: %receptor dimerization ErbB2/3
constant: false
value: 8.36983E-9
name: k103
type: Parameter

326399
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

102785
stoichiometry: 1.0
species: 326691
type: SpeciesReference

326531
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P)
type: Species

112735
stoichiometry: 1.0
species: 326931
type: SpeciesReference

105243
stoichiometry: 1.0
species: 326779
type: SpeciesReference

109519
stoichiometry: 1.0
species: 326543
type: SpeciesReference

081985
stoichiometry: 1.0
species: 326086
type: SpeciesReference

325940
name: EGF:ErbB1:ErbB2
is version of: P04626
has only substance units: true
has part: P00533
initial amount: 0.0
boundary condition: false
constant: false
type: Species
initial concentration: NaN
in compartment: 325898
notes: EGF:ErbB1:ErbB2 , plasma membrane
has version: P01133

087758
stoichiometry: 1.0
species: 326321
type: SpeciesReference

095958
stoichiometry: 1.0
species: 326525
type: SpeciesReference

329103
constant: true
value: 0.0141589
name: kd42
type: Parameter

329299
constant: false
value: 0.016
name: kd103
type: Parameter

082153
stoichiometry: 1.0
species: 326309
type: SpeciesReference

089652
stoichiometry: 1.0
species: 326549
type: SpeciesReference

326427
notes: 2(EGF:ErbB1)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P
type: Species

086988
stoichiometry: 1.0
species: 326363
type: SpeciesReference

098284
stoichiometry: 1.0
species: 326611
type: SpeciesReference

326305
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

328563
kinetic law: 112403
product: 112391
reactant: 112379
reactant: 112366
fast: false
reversible: true
name: v824 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2:ATP k123 kd123
type: Reaction

327059
kinetic law: 077659
product: 077647
reactant: 077635
reactant: 077623
fast: false
reversible: true
name: v58 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

327255
kinetic law: 082370
product: 082358
reactant: 082346
fast: false
reversible: true
name: v163 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k6 kd6
type: Reaction

329185
constant: true
value: 0.0
name: k68
type: Parameter

327883
kinetic law: 096993
product: 096981
reactant: 096969
reactant: 096957
fast: false
reversible: true
name: v478 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

326287
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:cPP
type: Species

110000
stoichiometry: 1.0
species: 326849
type: SpeciesReference

088130
stoichiometry: 1.0
species: 326545
type: SpeciesReference

327761
kinetic law: 094069
product: 094057
reactant: 094045
reactant: 094033
fast: false
reversible: true
name: v417 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

327103
kinetic law: 078718
product: 078706
reactant: 078694
reactant: 078682
fast: false
reversible: true
name: v82 2(ErbB2)#P:GAP:Grb2 + cPP -> 2(ErbB2)#P:GAP:Grb2:cPP k4b kd4
type: Reaction

099968
stoichiometry: 1.0
species: 326641
type: SpeciesReference

328337
kinetic law: 106954
product: 106942
reactant: 106930
reactant: 106918
fast: false
reversible: true
name: v710 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
type: Reaction

109375
stoichiometry: 1.0
species: 326543
type: SpeciesReference

089886
stoichiometry: 1.0
species: 326132
type: SpeciesReference

326154
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

327781
kinetic law: 094549
product: 094537
reactant: 094525
reactant: 094513
fast: false
reversible: true
name: v427 (Shc#P) + Grb2:Sos -> (Shc#P):Grb2:Sos k33 kd33
type: Reaction

079068
stoichiometry: 1.0
species: 326261
type: SpeciesReference

102543
stoichiometry: 1.0
species: 326675
type: SpeciesReference

093236
stoichiometry: 1.0
species: 326399
type: SpeciesReference

102254
stoichiometry: 1.0
species: 326539
type: SpeciesReference

085109
stoichiometry: 1.0
species: 326489
type: SpeciesReference

082683
stoichiometry: 1.0
species: 326411
type: SpeciesReference

326971
kinetic law: 075506
product: 075494
reactant: 075482
reactant: 075470
fast: false
reversible: true
name: v13 EGF:ErbB1:ATP + ErbB3 -> (EGF:ErbB1:ErbB3) k2b kd2b
type: Reaction

100497
stoichiometry: 1.0
species: 326361
type: SpeciesReference

096632
stoichiometry: 1.0
species: 326525
type: SpeciesReference

084854
stoichiometry: 1.0
species: 326521
type: SpeciesReference

326000
notes: ErbB2:ErbB2#P:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ErbB2:ErbB2_P:ATP
type: Species

078923
stoichiometry: 1.0
species: 326249
type: SpeciesReference

326152
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

091132
stoichiometry: 1.0
species: 326541
type: SpeciesReference

092443
stoichiometry: 1.0
species: 326447
type: SpeciesReference

099740
stoichiometry: 1.0
species: 326403
type: SpeciesReference

328291
kinetic law: 105847
product: 105835
reactant: 105822
reactant: 105810
fast: false
reversible: true
name: v687 PTEN + PIP2 -> PIP3:PTEN k104 kd104
type: Reaction

326861
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:_PP
type: Species

077768
stoichiometry: 1.0
species: 326124
type: SpeciesReference

327105
kinetic law: 078767
product: 078755
reactant: 078743
reactant: 078730
fast: false
reversible: true
name: v83 2(ErbB2)#P:GAP:Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
type: Reaction

087277
stoichiometry: 1.0
species: 326347
type: SpeciesReference

112466
stoichiometry: 1.0
species: 326477
type: SpeciesReference

088082
stoichiometry: 1.0
species: 326411
type: SpeciesReference

328339
kinetic law: 107003
product: 106991
reactant: 106979
reactant: 106966
fast: false
reversible: true
name: v711 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
type: Reaction

327881
kinetic law: 096944
product: 096932
reactant: 096920
reactant: 096908
fast: false
reversible: true
name: v477 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

327783
kinetic law: 094598
product: 094585
reactant: 094573
reactant: 094561
fast: false
reversible: true
name: v428 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

325950
notes: ErbB2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB2
type: Species

077393
stoichiometry: 1.0
species: 326056
type: SpeciesReference

326973
kinetic law: 075558
product: 075545
reactant: 075532
reactant: 075519
fast: false
reversible: true
name: v14 EGF:ErbB1:ATP + ErbB4 -> (EGF:ErbB1:ErbB4) k2b kd2b
type: Reaction

112391
stoichiometry: 1.0
species: 326040
type: SpeciesReference

112963
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326649
notes: (HRG:ErbB4:ErbB1) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB4:ErbB1)
type: Species

105835
stoichiometry: 1.0
species: 326799
type: SpeciesReference

081439
stoichiometry: 1.0
species: 326385
type: SpeciesReference

092106
stoichiometry: 1.0
species: 326561
type: SpeciesReference

082816
stoichiometry: 1.0
species: 325942
type: SpeciesReference

326150
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

328293
kinetic law: 105895
product: 105883
reactant: 105871
reactant: 105859
fast: false
reversible: true
name: v688 2(EGF:ErbB1)#P:GAP:Grb2 + Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

079708
stoichiometry: 1.0
species: 326313
type: SpeciesReference

093791
stoichiometry: 1.0
species: 326547
type: SpeciesReference

329391
constant: false
value: 0.0
name: k1
type: Parameter

086375
stoichiometry: 1.0
species: 326064
type: SpeciesReference

086255
stoichiometry: 1.0
species: 326539
type: SpeciesReference

103182
stoichiometry: 1.0
species: 326717
type: SpeciesReference

327527
kinetic law: 088553
product: 088541
reactant: 088529
reactant: 088517
fast: false
reversible: true
name: v300 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326751
notes: AKT:P:P:Pase4 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P:Pase4
type: Species

087385
stoichiometry: 1.0
species: 326333
type: SpeciesReference

328547
kinetic law: 111988
product: 111975
reactant: 111961
reactant: 111948
fast: false
reversible: true
name: v816 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

328333
kinetic law: 106858
product: 106846
reactant: 106834
reactant: 106822
fast: false
reversible: true
name: v708 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
type: Reaction

081817
stoichiometry: 1.0
species: 326309
type: SpeciesReference

104568
stoichiometry: 1.0
species: 326643
type: SpeciesReference

112314
stoichiometry: 1.0
species: 326469
type: SpeciesReference

326975
kinetic law: 075610
product: 075597
reactant: 075584
reactant: 075571
fast: false
reversible: true
name: v15 EGF:ErbB1:Inh + ErbB2 -> EGF:ErbB1:Inh:ErB2 k2b kd2b
type: Reaction

326004
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1:ATP
type: Species

326647
notes: (HRG:ErbB3:ErbB1) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB3:ErbB1)
type: Species

108580
stoichiometry: 1.0
species: 326831
type: SpeciesReference

084433
stoichiometry: 1.0
species: 326521
type: SpeciesReference

083949
stoichiometry: 1.0
species: 326493
type: SpeciesReference

087313
stoichiometry: 1.0
species: 326541
type: SpeciesReference

086569
stoichiometry: 1.0
species: 326112
type: SpeciesReference

100280
stoichiometry: 1.0
species: 326373
type: SpeciesReference

328369
kinetic law: 107726
product: 107714
reactant: 107702
reactant: 107690
fast: false
reversible: true
name: v726 (ERK#P#P)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
type: Reaction

105569
stoichiometry: 1.0
species: 326771
type: SpeciesReference

111828
stoichiometry: 1.0
species: 325996
type: SpeciesReference

328295
kinetic law: 105943
product: 105931
reactant: 105919
reactant: 105907
fast: false
reversible: true
name: v689 (ErbB1:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

098501
stoichiometry: 1.0
species: 326601
type: SpeciesReference

092877
stoichiometry: 1.0
species: 326533
type: SpeciesReference

110712
stoichiometry: 1.0
species: 326903
type: SpeciesReference

326901
boundary condition: true
type: Species
substance units: mole
notes: HRG , medium
in compartment: 325904
name: HRG
initial concentration: 0.0
constant: false
has only substance units: false
initial amount: NaN

328549
kinetic law: 112040
product: 112027
reactant: 112014
reactant: 112001
fast: false
reversible: true
name: v817 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

328299
kinetic law: 106039
product: 106027
reactant: 106015
reactant: 106003
fast: false
reversible: true
name: v691 (ErbB1:ErbB4)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

109591
stoichiometry: 1.0
species: 326877
type: SpeciesReference

327529
kinetic law: 088602
product: 088590
reactant: 088578
reactant: 088566
fast: false
reversible: true
name: v301 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

327101
kinetic law: 078670
product: 078658
reactant: 078646
reactant: 078634
fast: false
reversible: true
name: v81 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

328335
kinetic law: 106906
product: 106894
reactant: 106882
reactant: 106870
fast: false
reversible: true
name: v709 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
type: Reaction

097645
stoichiometry: 1.0
species: 326571
type: SpeciesReference

089938
stoichiometry: 1.0
species: 326387
type: SpeciesReference

097585
stoichiometry: 1.0
species: 326571
type: SpeciesReference

329311
constant: true
value: 0.1
name: kd106
type: Parameter

326645
notes: EGF_degraded , lysosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325902
name: EGF_degraded
type: Species

095489
stoichiometry: 1.0
species: 326413
type: SpeciesReference

090566
stoichiometry: 1.0
species: 326225
type: SpeciesReference

326211
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:cPP
type: Species

326977
kinetic law: 075662
product: 075649
reactant: 075636
reactant: 075623
fast: false
reversible: true
name: v16 ErbB3 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB3 k2b kd2b
type: Reaction

326002
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1
type: Species

085023
stoichiometry: 1.0
species: 326403
type: SpeciesReference

100400
stoichiometry: 1.0
species: 326641
type: SpeciesReference

083721
stoichiometry: 1.0
species: 326493
type: SpeciesReference

075793
stoichiometry: 1.0
species: 325972
type: SpeciesReference

078610
stoichiometry: 1.0
species: 326223
type: SpeciesReference

328297
kinetic law: 105991
product: 105979
reactant: 105967
reactant: 105955
fast: false
reversible: true
name: v690 (ErbB1:ErbB3)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

083082
stoichiometry: 1.0
species: 326455
type: SpeciesReference

106750
stoichiometry: 1.0
species: 326729
type: SpeciesReference

077333
stoichiometry: 1.0
species: 326088
type: SpeciesReference

094177
stoichiometry: 1.0
species: 326499
type: SpeciesReference

105400
stoichiometry: 1.0
species: 325916
type: SpeciesReference

107954
stoichiometry: 1.0
species: 326837
type: SpeciesReference

329313
constant: true
value: 2.63418E-8
name: k106b
type: Parameter

328045
kinetic law: 100449
product: 100437
reactant: 100424
fast: false
reversible: true
name: v560 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

327391
kinetic law: 085278
product: 085266
reactant: 085254
reactant: 085242
fast: false
reversible: true
name: v232 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63
type: Reaction

092721
stoichiometry: 1.0
species: 326433
type: SpeciesReference

102603
stoichiometry: 1.0
species: 326665
type: SpeciesReference

103074
stoichiometry: 1.0
species: 326707
type: SpeciesReference

075193
stoichiometry: 1.0
species: 325914
type: SpeciesReference

098657
stoichiometry: 1.0
species: 326599
type: SpeciesReference

100172
stoichiometry: 1.0
species: 326379
type: SpeciesReference

079370
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327465
kinetic law: 087060
product: 087048
reactant: 087036
reactant: 087024
fast: false
reversible: true
name: v269 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

329395
constant: true
value: 1.0E-4
name: KD_ATP
type: Parameter

326867
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
type: Species

327523
kinetic law: 088456
product: 088444
reactant: 088432
reactant: 088420
fast: false
reversible: true
name: v298 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326755
notes: RTK_Pase , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 70000.0
in compartment: 325908
name: RTK_Pase
type: Species

112855
stoichiometry: 1.0
species: 326913
type: SpeciesReference

326903
notes: HRG:ErbB3 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: HRG:ErbB3
type: Species

084589
stoichiometry: 1.0
species: 326140
type: SpeciesReference

079648
stoichiometry: 1.0
species: 326309
type: SpeciesReference

076607
stoichiometry: 1.0
species: 326026
type: SpeciesReference

094189
stoichiometry: 1.0
species: 326575
type: SpeciesReference

074890
stoichiometry: 1.0
species: 325910
type: SpeciesReference

104676
stoichiometry: 1.0
species: 326767
type: SpeciesReference

077285
stoichiometry: 1.0
species: 326084
type: SpeciesReference

078791
stoichiometry: 1.0
species: 326056
type: SpeciesReference

090468
stoichiometry: 1.0
species: 326241
type: SpeciesReference

081647
stoichiometry: 1.0
species: 326114
type: SpeciesReference

092515
stoichiometry: 1.0
species: 326451
type: SpeciesReference

097753
stoichiometry: 1.0
species: 326597
type: SpeciesReference

328365
kinetic law: 107630
product: 107618
reactant: 107605
reactant: 107593
fast: false
reversible: true
name: v724 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k110 kd110
type: Reaction

087036
stoichiometry: 1.0
species: 326361
type: SpeciesReference

326643
notes: 2(ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)
type: Species

087422
stoichiometry: 1.0
species: 326277
type: SpeciesReference

099320
stoichiometry: 1.0
species: 326641
type: SpeciesReference

328043
kinetic law: 100412
product: 100400
reactant: 100388
fast: false
reversible: true
name: v559 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

077441
stoichiometry: 1.0
species: 326056
type: SpeciesReference

329315
constant: true
value: 0.1
name: kd106b
type: Parameter

092661
stoichiometry: 1.0
species: 326491
type: SpeciesReference

106979
stoichiometry: 1.0
species: 326699
type: SpeciesReference

328141
kinetic law: 102230
product: 102218
reactant: 102206
reactant: 102194
fast: false
reversible: true
name: v612 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k64 kd64
type: Reaction

098705
stoichiometry: 1.0
species: 326601
type: SpeciesReference

328331
kinetic law: 106810
product: 106798
reactant: 106786
reactant: 106774
fast: false
reversible: true
name: v707 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
type: Reaction

326753
notes: AKT#P:Pase4 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT_P:Pase4
type: Species

327525
kinetic law: 088504
product: 088492
reactant: 088480
reactant: 088468
fast: false
reversible: true
name: v299 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

329393
notes: KDATP=1e-4
constant: false
value: 1.8704E-8
name: k122
type: Parameter

326869
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
type: Species

326905
notes: HRG:ErbB4 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: HRG:ErbB4
type: Species

327311
kinetic law: 083383
product: 083371
reactant: 083359
fast: false
reversible: true
name: v191 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP k7 kd7
type: Reaction

101760
stoichiometry: 1.0
species: 325956
type: SpeciesReference

327463
kinetic law: 087012
product: 087000
reactant: 086988
reactant: 086976
fast: false
reversible: true
name: v268 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

078069
stoichiometry: 1.0
species: 326056
type: SpeciesReference

084962
stoichiometry: 1.0
species: 326533
type: SpeciesReference

113263
stoichiometry: 1.0
species: 326945
type: SpeciesReference

327461
kinetic law: 086964
product: 086952
reactant: 086940
reactant: 086928
fast: false
reversible: true
name: v267 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

107702
stoichiometry: 1.0
species: 326687
type: SpeciesReference

093985
stoichiometry: 1.0
species: 326503
type: SpeciesReference

094610
stoichiometry: 1.0
species: 326431
type: SpeciesReference

103712
stoichiometry: 1.0
species: 326743
type: SpeciesReference

086784
stoichiometry: 1.0
species: 326541
type: SpeciesReference

105629
stoichiometry: 1.0
species: 325942
type: SpeciesReference

097693
stoichiometry: 1.0
species: 326573
type: SpeciesReference

083612
stoichiometry: 1.0
species: 326427
type: SpeciesReference

095105
stoichiometry: 1.0
species: 326577
type: SpeciesReference

076079
stoichiometry: 1.0
species: 325932
type: SpeciesReference

326641
notes: R_degraded , lysosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325902
name: R_degraded
type: Species

328367
kinetic law: 107678
product: 107666
reactant: 107654
reactant: 107642
fast: false
reversible: true
name: v725 ERK#P#P + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
type: Reaction

327671
kinetic law: 092070
product: 092058
reactant: 092046
reactant: 092034
fast: false
reversible: true
name: v372 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
type: Reaction

328041
kinetic law: 100376
product: 100364
reactant: 100352
fast: false
reversible: true
name: v558 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

109002
stoichiometry: 1.0
species: 326693
type: SpeciesReference

102338
stoichiometry: 1.0
species: 326627
type: SpeciesReference

328361
kinetic law: 107532
product: 107520
reactant: 107508
reactant: 107496
fast: false
reversible: true
name: v722 PIP3 + Shp -> PIP3:Shp k109 kd109
type: Reaction

085193
stoichiometry: 1.0
species: 326481
type: SpeciesReference

329317
constant: true
value: 3.33E-5
name: k107
type: Parameter

326907
notes: (HRG:ErbB4) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB4)
type: Species

083480
stoichiometry: 1.0
species: 326493
type: SpeciesReference

082924
stoichiometry: 1.0
species: 326441
type: SpeciesReference

326759
notes: (ErbB1:ErbB4)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:RTK_Pase
type: Species

090784
stoichiometry: 1.0
species: 326060
type: SpeciesReference

327469
kinetic law: 087157
product: 087145
reactant: 087133
reactant: 087121
fast: false
reversible: true
name: v271 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

326158
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

326863
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):PI3K:Ras:GDP
type: Species

096788
stoichiometry: 1.0
species: 326411
type: SpeciesReference

080848
stoichiometry: 1.0
species: 326309
type: SpeciesReference

077550
stoichiometry: 1.0
species: 326106
type: SpeciesReference

080993
stoichiometry: 1.0
species: 326309
type: SpeciesReference

329399
constant: true
value: 0.1
name: kd123h
type: Parameter

109086
stoichiometry: 1.0
species: 326541
type: SpeciesReference

327673
kinetic law: 092118
product: 092106
reactant: 092094
reactant: 092082
fast: false
reversible: true
name: v373 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
type: Reaction

091084
stoichiometry: 1.0
species: 326541
type: SpeciesReference

089217
stoichiometry: 1.0
species: 326331
type: SpeciesReference

109891
stoichiometry: 1.0
species: 326885
type: SpeciesReference

106534
stoichiometry: 1.0
species: 326793
type: SpeciesReference

089730
stoichiometry: 1.0
species: 326407
type: SpeciesReference

079176
stoichiometry: 1.0
species: 326056
type: SpeciesReference

082792
stoichiometry: 1.0
species: 326419
type: SpeciesReference

100388
stoichiometry: 1.0
species: 326367
type: SpeciesReference

087169
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328363
kinetic law: 107581
product: 107568
reactant: 107556
reactant: 107544
fast: false
reversible: true
name: v723 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k110 kd110
type: Reaction

329319
constant: true
value: 0.1
name: kd107
type: Parameter

110339
stoichiometry: 1.0
species: 326699
type: SpeciesReference

326909
notes: ErbB1_h , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1_h
type: Species

327467
kinetic law: 087109
product: 087097
reactant: 087085
reactant: 087073
fast: false
reversible: true
name: v270 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

327521
kinetic law: 088408
product: 088396
reactant: 088384
reactant: 088372
fast: false
reversible: true
name: v297 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326757
notes: (ErbB1:ErbB3)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:RTK_Pase
type: Species

326865
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
type: Species

329397
constant: true
value: 0.0
name: k123h
type: Parameter

326156
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

093020
stoichiometry: 1.0
species: 326539
type: SpeciesReference

109182
stoichiometry: 1.0
species: 326541
type: SpeciesReference

088420
stoichiometry: 1.0
species: 326399
type: SpeciesReference

077877
stoichiometry: 1.0
species: 326056
type: SpeciesReference

113096
stoichiometry: 1.0
species: 326425
type: SpeciesReference

087950
stoichiometry: 1.0
species: 326347
type: SpeciesReference

105726
stoichiometry: 1.0
species: 325972
type: SpeciesReference

109940
stoichiometry: 1.0
species: 326885
type: SpeciesReference

084240
stoichiometry: 1.0
species: 326309
type: SpeciesReference

096860
stoichiometry: 1.0
species: 326577
type: SpeciesReference

327675
kinetic law: 092166
product: 092154
reactant: 092142
reactant: 092130
fast: false
reversible: true
name: v374 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b
type: Reaction

082213
stoichiometry: 1.0
species: 326417
type: SpeciesReference

111348
stoichiometry: 1.0
species: 326925
type: SpeciesReference

078827
stoichiometry: 1.0
species: 326241
type: SpeciesReference

088288
stoichiometry: 1.0
species: 326543
type: SpeciesReference

329065
constant: true
value: 1.17E-6
name: k29
type: Parameter

326209
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos
type: Species

328147
kinetic law: 102374
product: 102362
reactant: 102350
reactant: 102338
fast: false
reversible: true
name: v615 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
type: Reaction

094249
stoichiometry: 1.0
species: 326217
type: SpeciesReference

085736
stoichiometry: 1.0
species: 326327
type: SpeciesReference

327665
kinetic law: 091926
product: 091914
reactant: 091902
reactant: 091890
fast: false
reversible: true
name: v369 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
type: Reaction

327399
kinetic law: 085470
product: 085458
reactant: 085446
reactant: 085434
fast: false
reversible: true
name: v236 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

326523
notes: (Shc#P) , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Shc_P)
type: Species

080272
stoichiometry: 1.0
species: 326309
type: SpeciesReference

329281
constant: false
value: 4.42
name: k99
type: Parameter

112638
stoichiometry: 1.0
species: 326919
type: SpeciesReference

099668
stoichiometry: 1.0
species: 325958
type: SpeciesReference

081865
stoichiometry: 1.0
species: 326309
type: SpeciesReference

098885
stoichiometry: 1.0
species: 326617
type: SpeciesReference

092298
stoichiometry: 1.0
species: 326441
type: SpeciesReference

091626
stoichiometry: 1.0
species: 326301
type: SpeciesReference

085893
stoichiometry: 1.0
species: 326233
type: SpeciesReference

087854
stoichiometry: 1.0
species: 326319
type: SpeciesReference

329201
constant: true
value: 0.0
name: k72
type: Parameter

113011
stoichiometry: 1.0
species: 325980
type: SpeciesReference

095321
stoichiometry: 1.0
species: 326429
type: SpeciesReference

081925
stoichiometry: 1.0
species: 326405
type: SpeciesReference

078358
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327305
kinetic law: 083275
product: 083263
reactant: 083251
fast: false
reversible: true
name: v188 2(ErbB2)#P -> 2(ErbB2)#P k7 kd7
type: Reaction

328999
constant: true
value: 9.34641E-6
name: k8b
type: Parameter

327901
kinetic law: 097429
product: 097417
reactant: 097405
reactant: 097393
fast: false
reversible: true
name: v487 Pase1 + (Raf#P)_i -> (Raf#P:Pase1)_i k42 kd42
type: Reaction

079852
stoichiometry: 1.0
species: 326319
type: SpeciesReference

098163
stoichiometry: 1.0
species: 326589
type: SpeciesReference

326313
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

329177
constant: true
value: 0.2
name: kd66
type: Parameter

079213
stoichiometry: 1.0
species: 326273
type: SpeciesReference

074951
stoichiometry: 1.0
species: 325910
type: SpeciesReference

327247
kinetic law: 082189
product: 082177
reactant: 082165
reactant: 082153
fast: false
reversible: true
name: v159 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5
type: Reaction

326411
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos
type: Species

105340
stoichiometry: 1.0
species: 325938
type: SpeciesReference

109723
stoichiometry: 1.0
species: 326747
type: SpeciesReference

093464
stoichiometry: 1.0
species: 326249
type: SpeciesReference

329309
constant: true
value: 1.33E-5
name: k106
type: Parameter

105085
stoichiometry: 1.0
species: 326671
type: SpeciesReference

328149
kinetic law: 102422
product: 102410
reactant: 102398
reactant: 102386
fast: false
reversible: true
name: v616 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k65 kd65
type: Reaction

086844
stoichiometry: 1.0
species: 326201
type: SpeciesReference

097369
stoichiometry: 1.0
species: 326337
type: SpeciesReference

096018
stoichiometry: 1.0
species: 326403
type: SpeciesReference

077913
stoichiometry: 1.0
species: 326136
type: SpeciesReference

326525
notes: (Shc#P):Grb2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Shc_P):Grb2
type: Species

329067
constant: true
value: 3.1
name: kd29
type: Parameter

085555
stoichiometry: 1.0
species: 326327
type: SpeciesReference

327667
kinetic law: 091974
product: 091962
reactant: 091950
reactant: 091938
fast: false
reversible: true
name: v370 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
type: Reaction

327981
kinetic law: 099296
product: 099284
reactant: 099272
fast: false
reversible: true
name: v527 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> R_degraded k60 kd60
type: Reaction

327397
kinetic law: 085422
product: 085410
reactant: 085398
reactant: 085386
fast: false
reversible: true
name: v235 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

107135
stoichiometry: 1.0
species: 326807
type: SpeciesReference

329203
notes: %10.5
constant: true
value: 5.01187
name: kd72
type: Parameter

075109
stoichiometry: 1.0
species: 325928
type: SpeciesReference

108844
stoichiometry: 1.0
species: 326629
type: SpeciesReference

080488
stoichiometry: 1.0
species: 326239
type: SpeciesReference

095285
stoichiometry: 1.0
species: 326523
type: SpeciesReference

100892
stoichiometry: 1.0
species: 326345
type: SpeciesReference

326315
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

327459
kinetic law: 086916
product: 086904
reactant: 086892
reactant: 086880
fast: false
reversible: true
name: v266 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

078298
stoichiometry: 1.0
species: 326197
type: SpeciesReference

327307
kinetic law: 083311
product: 083299
reactant: 083287
fast: false
reversible: true
name: v189 (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P k7 kd7
type: Reaction

105001
stoichiometry: 1.0
species: 326419
type: SpeciesReference

326413
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2
type: Species

101555
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327245
kinetic law: 082141
product: 082129
reactant: 082117
reactant: 082105
fast: false
reversible: true
name: v158 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k5 kd5
type: Reaction

329175
notes: %
constant: true
value: 1.5E-5
name: k66
type: Parameter

094393
stoichiometry: 1.0
species: 326325
type: SpeciesReference

103784
stoichiometry: 1.0
species: 326747
type: SpeciesReference

329069
constant: true
value: 0.1
name: kd32
type: Parameter

084095
stoichiometry: 1.0
species: 326473
type: SpeciesReference

107894
stoichiometry: 1.0
species: 326683
type: SpeciesReference

099896
stoichiometry: 1.0
species: 326641
type: SpeciesReference

090059
stoichiometry: 1.0
species: 326547
type: SpeciesReference

101446
stoichiometry: 1.0
species: 326641
type: SpeciesReference

106316
stoichiometry: 1.0
species: 326717
type: SpeciesReference

327983
kinetic law: 099332
product: 099320
reactant: 099308
fast: false
reversible: true
name: v528 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60
type: Reaction

078130
stoichiometry: 1.0
species: 326154
type: SpeciesReference

326527
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P)
type: Species

099812
stoichiometry: 1.0
species: 326399
type: SpeciesReference

080909
stoichiometry: 1.0
species: 326363
type: SpeciesReference

327669
kinetic law: 092022
product: 092010
reactant: 091998
reactant: 091986
fast: false
reversible: true
name: v371 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b
type: Reaction

084011
stoichiometry: 1.0
species: 326479
type: SpeciesReference

097874
stoichiometry: 1.0
species: 326599
type: SpeciesReference

095069
stoichiometry: 1.0
species: 326285
type: SpeciesReference

076139
stoichiometry: 1.0
species: 325980
type: SpeciesReference

092322
stoichiometry: 1.0
species: 326551
type: SpeciesReference

083263
stoichiometry: 1.0
species: 326475
type: SpeciesReference

328995
constant: true
value: 0.2
name: kd8
type: Parameter

327301
kinetic law: 083203
product: 083191
reactant: 083179
fast: false
reversible: true
name: v186 (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P k7 kd7
type: Reaction

077055
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327879
kinetic law: 096896
product: 096884
reactant: 096872
reactant: 096860
fast: false
reversible: true
name: v476 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

099006
stoichiometry: 1.0
species: 326639
type: SpeciesReference

327905
kinetic law: 097525
product: 097513
reactant: 097501
reactant: 097489
fast: false
reversible: true
name: v489 Raf + Pase1 -> Raf#P:Pase1 k43 kd43
type: Reaction

325898
is: GO:0005886
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 2.0
name: plasma membrane
type: Compartment

108134
stoichiometry: 1.0
species: 326703
type: SpeciesReference

328143
kinetic law: 102278
product: 102266
reactant: 102254
reactant: 102242
fast: false
reversible: true
name: v613 ERK#P#P + Sos -> (ERK#P#P):Sos k64 kd64
type: Reaction

091432
stoichiometry: 1.0
species: 326265
type: SpeciesReference

107786
stoichiometry: 1.0
species: 326629
type: SpeciesReference

109675
stoichiometry: 1.0
species: 326747
type: SpeciesReference

327395
kinetic law: 085374
product: 085362
reactant: 085350
reactant: 085338
fast: false
reversible: true
name: v234 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

328049
kinetic law: 100521
product: 100509
reactant: 100497
fast: false
reversible: true
name: v564 (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
type: Reaction

327985
kinetic law: 099368
product: 099356
reactant: 099344
fast: false
reversible: true
name: v529 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60 kd60
type: Reaction

082431
stoichiometry: 1.0
species: 326427
type: SpeciesReference

104084
stoichiometry: 1.0
species: 326471
type: SpeciesReference

326529
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P)
type: Species

088203
stoichiometry: 1.0
species: 326080
type: SpeciesReference

328145
kinetic law: 102326
product: 102314
reactant: 102302
reactant: 102290
fast: false
reversible: true
name: v614 (ERK#P#P)_i + Sos -> ((ERK#P#P):Sos)_i k64 kd64
type: Reaction

088771
stoichiometry: 1.0
species: 326545
type: SpeciesReference

097934
stoichiometry: 1.0
species: 326601
type: SpeciesReference

328401
kinetic law: 108496
product: 108484
reactant: 108472
reactant: 108460
fast: false
reversible: true
name: v742 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
type: Reaction

093128
stoichiometry: 1.0
species: 326092
type: SpeciesReference

075859
stoichiometry: 1.0
species: 325978
type: SpeciesReference

075636
stoichiometry: 1.0
species: 325926
type: SpeciesReference

329179
notes: %PIP2 binds to PI3K
constant: true
value: 5.0E-5
name: k67
type: Parameter

082707
stoichiometry: 1.0
species: 326080
type: SpeciesReference

328997
constant: true
value: 0.02
name: kd8b
type: Parameter

327303
kinetic law: 083239
product: 083227
reactant: 083215
fast: false
reversible: true
name: v187 (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P k7 kd7
type: Reaction

327249
kinetic law: 082237
product: 082225
reactant: 082213
reactant: 082201
fast: false
reversible: true
name: v160 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5
type: Reaction

075350
stoichiometry: 1.0
species: 325944
type: SpeciesReference

326311
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

327903
kinetic law: 097477
product: 097465
reactant: 097453
reactant: 097441
fast: false
reversible: true
name: v488 Pase1 + Raf#P -> Raf#P:Pase1 k42 kd42
type: Reaction

112014
stoichiometry: 1.0
species: 325980
type: SpeciesReference

081293
stoichiometry: 1.0
species: 326379
type: SpeciesReference

094585
stoichiometry: 1.0
species: 326060
type: SpeciesReference

094827
stoichiometry: 1.0
species: 326363
type: SpeciesReference

327393
kinetic law: 085326
product: 085314
reactant: 085302
reactant: 085290
fast: false
reversible: true
name: v233 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

091288
stoichiometry: 1.0
species: 326369
type: SpeciesReference

328047
kinetic law: 100485
product: 100473
reactant: 100461
fast: false
reversible: true
name: v563 (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
type: Reaction

326293
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

092937
stoichiometry: 1.0
species: 326563
type: SpeciesReference

327041
kinetic law: 077225
product: 077213
reactant: 077201
reactant: 077189
fast: false
reversible: true
name: v48 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k4 kd4
type: Reaction

329209
constant: false
value: 6.36184E-7
name: k74
type: Parameter

085254
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327987
kinetic law: 099404
product: 099392
reactant: 099380
fast: false
reversible: true
name: v530 2(EGF:ErbB1)#P:GAP:Shc -> R_degraded k60 kd60
type: Reaction

077237
stoichiometry: 1.0
species: 326080
type: SpeciesReference

326979
kinetic law: 075714
product: 075701
reactant: 075688
reactant: 075675
fast: false
reversible: true
name: v17 ErbB4 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB4 k2b kd2b
type: Reaction

102700
stoichiometry: 1.0
species: 326685
type: SpeciesReference

326201
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos
type: Species

095765
stoichiometry: 1.0
species: 326523
type: SpeciesReference

107472
stoichiometry: 1.0
species: 326799
type: SpeciesReference

083371
stoichiometry: 1.0
species: 326483
type: SpeciesReference

327909
kinetic law: 097621
product: 097609
reactant: 097597
reactant: 097585
fast: false
reversible: true
name: v491 (Raf#P)_i + (MEK#P)_i -> (MEK#P:Raf#P)_i k44 kd52
type: Reaction

091770
stoichiometry: 1.0
species: 326311
type: SpeciesReference

325956
has part: P00533
in compartment: 325906
type: Species
initial amount: 0.0
has only substance units: true
initial concentration: NaN
boundary condition: false
constant: false
name: (EGF:ErbB1:ErbB3)
has version: P01133
notes: (EGF:ErbB1:ErbB3) , endosomal membrane

091842
stoichiometry: 1.0
species: 326551
type: SpeciesReference

076247
stoichiometry: 1.0
species: 325996
type: SpeciesReference

328555
kinetic law: 112197
product: 112184
reactant: 112170
reactant: 112157
fast: false
reversible: true
name: v820 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

078694
stoichiometry: 1.0
species: 326056
type: SpeciesReference

326419
notes: 2(EGF:ErbB1)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2
type: Species

111000
stoichiometry: 1.0
species: 325910
type: SpeciesReference

076199
stoichiometry: 1.0
species: 325994
type: SpeciesReference

089253
stoichiometry: 1.0
species: 326547
type: SpeciesReference

101338
stoichiometry: 1.0
species: 326641
type: SpeciesReference

107351
stoichiometry: 1.0
species: 326805
type: SpeciesReference

327777
kinetic law: 094453
product: 094441
reactant: 094429
reactant: 094417
fast: false
reversible: true
name: v425 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

112589
stoichiometry: 1.0
species: 325912
type: SpeciesReference

327875
kinetic law: 096800
product: 096788
reactant: 096776
reactant: 096764
fast: false
reversible: true
name: v474 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

084397
stoichiometry: 1.0
species: 326072
type: SpeciesReference

326291
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:cPP
type: Species

103218
stoichiometry: 1.0
species: 326685
type: SpeciesReference

080512
stoichiometry: 1.0
species: 326309
type: SpeciesReference

096596
stoichiometry: 1.0
species: 326249
type: SpeciesReference

327043
kinetic law: 077273
product: 077261
reactant: 077249
reactant: 077237
fast: false
reversible: true
name: v49 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4 kd4
type: Reaction

103351
stoichiometry: 1.0
species: 326707
type: SpeciesReference

327989
kinetic law: 099440
product: 099428
reactant: 099416
fast: false
reversible: true
name: v531 2(EGF:ErbB1)#P:GAP:(Shc#P) -> R_degraded k60 kd60
type: Reaction

086904
stoichiometry: 1.0
species: 326152
type: SpeciesReference

088880
stoichiometry: 1.0
species: 326257
type: SpeciesReference

084638
stoichiometry: 1.0
species: 326144
type: SpeciesReference

329287
constant: true
value: 1.0
name: k100
type: Parameter

326203
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:cPP
type: Species

329289
constant: true
value: 8.33E-7
name: k101
type: Parameter

081065
stoichiometry: 1.0
species: 326191
type: SpeciesReference

325958
notes: ErbB4 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB4
type: Species

090312
stoichiometry: 1.0
species: 326549
type: SpeciesReference

108628
stoichiometry: 1.0
species: 326825
type: SpeciesReference

101869
stoichiometry: 1.0
species: 326649
type: SpeciesReference

110448
stoichiometry: 1.0
species: 326899
type: SpeciesReference

327907
kinetic law: 097573
product: 097561
reactant: 097549
reactant: 097537
fast: false
reversible: true
name: v490 Raf + Pase1 -> (Raf#P:Pase1)_i k43 kd43
type: Reaction

093839
stoichiometry: 1.0
species: 326429
type: SpeciesReference

090276
stoichiometry: 1.0
species: 326305
type: SpeciesReference

327779
kinetic law: 094501
product: 094489
reactant: 094477
reactant: 094465
fast: false
reversible: true
name: v426 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

088541
stoichiometry: 1.0
species: 326389
type: SpeciesReference

103928
stoichiometry: 1.0
species: 326735
type: SpeciesReference

327877
kinetic law: 096848
product: 096836
reactant: 096824
reactant: 096812
fast: false
reversible: true
name: v475 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

327045
kinetic law: 077321
product: 077309
reactant: 077297
reactant: 077285
fast: false
reversible: true
name: v50 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4 kd4
type: Reaction

328557
kinetic law: 112249
product: 112236
reactant: 112223
reactant: 112210
fast: false
reversible: true
name: v821 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

080380
stoichiometry: 1.0
species: 326341
type: SpeciesReference

104192
stoichiometry: 1.0
species: 326763
type: SpeciesReference

080056
stoichiometry: 1.0
species: 326275
type: SpeciesReference

093705
stoichiometry: 1.0
species: 326565
type: SpeciesReference

094477
stoichiometry: 1.0
species: 326575
type: SpeciesReference

097150
stoichiometry: 1.0
species: 326577
type: SpeciesReference

108424
stoichiometry: 1.0
species: 326853
type: SpeciesReference

329205
notes: %Pase4 binds AKT:P:P
constant: false
value: 0.00374845
name: k73
type: Parameter

102482
stoichiometry: 1.0
species: 326629
type: SpeciesReference

104941
stoichiometry: 1.0
species: 326671
type: SpeciesReference

327241
kinetic law: 082045
product: 082033
reactant: 082021
reactant: 082009
fast: false
reversible: true
name: v156 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5
type: Reaction

101663
stoichiometry: 1.0
species: 326641
type: SpeciesReference

110195
stoichiometry: 1.0
species: 326695
type: SpeciesReference

329285
constant: true
value: 0.001
name: kd100
type: Parameter

093572
stoichiometry: 1.0
species: 326277
type: SpeciesReference

102797
stoichiometry: 1.0
species: 326693
type: SpeciesReference

106256
stoichiometry: 1.0
species: 326689
type: SpeciesReference

095850
stoichiometry: 1.0
species: 326503
type: SpeciesReference

111120
stoichiometry: 1.0
species: 326917
type: SpeciesReference

110231
stoichiometry: 1.0
species: 326885
type: SpeciesReference

078202
stoichiometry: 1.0
species: 326189
type: SpeciesReference

089665
stoichiometry: 1.0
species: 326421
type: SpeciesReference

326205
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos
type: Species

329061
constant: true
value: 5.0E-6
name: k28b
type: Parameter

105159
stoichiometry: 1.0
species: 326425
type: SpeciesReference

325952
notes: (EGF:ErbB1:ErbB2) , endosomal membrane
initial concentration: NaN
in compartment: 325906
has part: P00533
type: Species
has only substance units: true
constant: false
name: (EGF:ErbB1:ErbB2)
initial amount: 0.0
boundary condition: false
has version: P01133

105231
stoichiometry: 1.0
species: 326777
type: SpeciesReference

108364
stoichiometry: 1.0
species: 326629
type: SpeciesReference

081973
stoichiometry: 1.0
species: 326309
type: SpeciesReference

087746
stoichiometry: 1.0
species: 326545
type: SpeciesReference

074842
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

085097
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327871
kinetic law: 096704
product: 096692
reactant: 096680
reactant: 096668
fast: false
reversible: true
name: v472 Sos + (Shc#P):Grb2 -> (Shc#P):Grb2:Sos k40 kd40
type: Reaction

328329
kinetic law: 106762
product: 106750
reactant: 106738
reactant: 106726
fast: false
reversible: true
name: v706 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k106 kd106
type: Reaction

327243
kinetic law: 082093
product: 082081
reactant: 082069
reactant: 082057
fast: false
reversible: true
name: v157 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5
type: Reaction

326299
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

088142
stoichiometry: 1.0
species: 326421
type: SpeciesReference

327773
kinetic law: 094357
product: 094345
reactant: 094333
reactant: 094321
fast: false
reversible: true
name: v423 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

329173
constant: true
value: 0.0
name: k65
type: Parameter

326415
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

327047
kinetic law: 077369
product: 077357
reactant: 077345
reactant: 077333
fast: false
reversible: true
name: v52 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
type: Reaction

098272
stoichiometry: 1.0
species: 326585
type: SpeciesReference

328551
kinetic law: 112092
product: 112079
reactant: 112066
reactant: 112053
fast: false
reversible: true
name: v818 2(ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

327309
kinetic law: 083347
product: 083335
reactant: 083323
fast: false
reversible: true
name: v190 (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P k7 kd7
type: Reaction

326317
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

091938
stoichiometry: 1.0
species: 326551
type: SpeciesReference

113191
stoichiometry: 1.0
species: 326425
type: SpeciesReference

103423
stoichiometry: 1.0
species: 326727
type: SpeciesReference

329207
constant: false
value: 0.5
name: kd73
type: Parameter

326295
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

087902
stoichiometry: 1.0
species: 326233
type: SpeciesReference

326521
initial concentration: NaN
is described by: http://identifiers.org/omim/108355
constant: false
has only substance units: true
name: Grb2
in compartment: 325908
initial amount: 1264.91
notes: Grb2 , cytoplasm
is version of: P62993
type: Species
boundary condition: false

329283
constant: true
value: 0.001
name: Kinh3
type: Parameter

076343
stoichiometry: 1.0
species: 326004
type: SpeciesReference

090892
stoichiometry: 1.0
species: 326541
type: SpeciesReference

079672
stoichiometry: 1.0
species: 326307
type: SpeciesReference

108290
stoichiometry: 1.0
species: 326843
type: SpeciesReference

329063
constant: true
value: 0.0053
name: kd28b
type: Parameter

108098
stoichiometry: 1.0
species: 326843
type: SpeciesReference

326207
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:cPP
type: Species

075085
stoichiometry: 1.0
species: 325914
type: SpeciesReference

076765
stoichiometry: 1.0
species: 325980
type: SpeciesReference

109447
stoichiometry: 1.0
species: 326871
type: SpeciesReference

325954
notes: ErbB3 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB3
type: Species

096234
stoichiometry: 1.0
species: 326483
type: SpeciesReference

085530
stoichiometry: 1.0
species: 326511
type: SpeciesReference

108954
stoichiometry: 1.0
species: 326689
type: SpeciesReference

080656
stoichiometry: 1.0
species: 326309
type: SpeciesReference

329171
constant: true
value: 0.2
name: kd65
type: Parameter

107027
stoichiometry: 1.0
species: 326703
type: SpeciesReference

327873
kinetic law: 096752
product: 096740
reactant: 096728
reactant: 096716
fast: false
reversible: true
name: v473 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

326297
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

327775
kinetic law: 094405
product: 094393
reactant: 094381
reactant: 094369
fast: false
reversible: true
name: v424 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

328553
kinetic law: 112144
product: 112131
reactant: 112118
reactant: 112105
fast: false
reversible: true
name: v819 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

327049
kinetic law: 077417
product: 077405
reactant: 077393
reactant: 077381
fast: false
reversible: true
name: v53 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
type: Reaction

326319
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2:Sos
type: Species

326417
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

103940
stoichiometry: 1.0
species: 326749
type: SpeciesReference

103832
stoichiometry: 1.0
species: 326735
type: SpeciesReference

326761
notes: 2(EGF:ErbB1)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:RTK_Pase
type: Species

096306
stoichiometry: 1.0
species: 326449
type: SpeciesReference

328323
kinetic law: 106618
product: 106606
reactant: 106594
reactant: 106582
fast: false
reversible: true
name: v703 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k106 kd106
type: Reaction

328489
kinetic law: 110604
product: 110592
reactant: 110580
reactant: 110568
fast: false
reversible: true
name: v786 HRG:ErbB3 + ErbB2 -> (HRG:ErbB3):ErbB2 k120 kd120
type: Reaction

327517
kinetic law: 088312
product: 088300
reactant: 088288
reactant: 088276
fast: false
reversible: true
name: v295 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

100437
stoichiometry: 1.0
species: 326641
type: SpeciesReference

328537
kinetic law: 111744
product: 111732
reactant: 111720
reactant: 111708
fast: false
reversible: true
name: v811 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1):ATP k123 kd123
type: Reaction

327495
kinetic law: 087782
product: 087770
reactant: 087758
reactant: 087746
fast: false
reversible: true
name: v284 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

327493
kinetic law: 087734
product: 087722
reactant: 087710
reactant: 087698
fast: false
reversible: true
name: v283 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

327791
kinetic law: 094791
product: 094779
reactant: 094767
reactant: 094755
fast: false
reversible: true
name: v432 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

094731
stoichiometry: 1.0
species: 326205
type: SpeciesReference

328261
kinetic law: 105122
product: 105109
reactant: 105097
reactant: 105085
fast: false
reversible: true
name: v672 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101
type: Reaction

328211
kinetic law: 103916
product: 103904
reactant: 103892
reactant: 103880
fast: false
reversible: true
name: v647 AKT + Pase4 -> AKT#P:Pase4 k75 kd75
type: Reaction

083733
stoichiometry: 1.0
species: 326501
type: SpeciesReference

327405
kinetic law: 085615
product: 085603
reactant: 085591
reactant: 085579
fast: false
reversible: true
name: v239 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd24
type: Reaction

327715
kinetic law: 092961
product: 092949
reactant: 092937
fast: false
reversible: true
name: v394 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23
type: Reaction

326561
notes: (ErbB1:ErbB3)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Shc
type: Species

326038
notes: (HRG:ErbB4):ErbB2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB4):ErbB2
type: Species

326989
kinetic law: 075970
product: 075958
reactant: 075946
reactant: 075934
fast: false
reversible: true
name: v22 (EGF:ErbB1:ErbB3) + ATP -> (EGF:ErbB1:ErbB3):ATP k122 kd122
type: Reaction

104556
stoichiometry: 1.0
species: 326755
type: SpeciesReference

081829
stoichiometry: 1.0
species: 326401
type: SpeciesReference

093428
stoichiometry: 1.0
species: 326355
type: SpeciesReference

327515
kinetic law: 088263
product: 088251
reactant: 088239
reactant: 088227
fast: false
reversible: true
name: v294 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

328487
kinetic law: 110556
product: 110544
reactant: 110532
reactant: 110520
fast: false
reversible: true
name: v785 ErbB4 + HRG -> HRG:ErbB4 k119 kd119
type: Reaction

111684
stoichiometry: 1.0
species: 325986
type: SpeciesReference

326763
notes: 2(ErbB2)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:RTK_Pase
type: Species

328535
kinetic law: 111696
product: 111684
reactant: 111672
reactant: 111660
fast: false
reversible: true
name: v810 (ErbB1:ErbB4)#P + ATP -> (EGF:ErbB1:ErbB4):ATP k123 kd123
type: Reaction

328321
kinetic law: 106570
product: 106558
reactant: 106546
reactant: 106534
fast: false
reversible: true
name: v702 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k106 kd106
type: Reaction

087373
stoichiometry: 1.0
species: 326337
type: SpeciesReference

327497
kinetic law: 087830
product: 087818
reactant: 087806
reactant: 087794
fast: false
reversible: true
name: v285 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

112327
stoichiometry: 1.0
species: 325980
type: SpeciesReference

086411
stoichiometry: 1.0
species: 326076
type: SpeciesReference

098211
stoichiometry: 1.0
species: 326585
type: SpeciesReference

088372
stoichiometry: 1.0
species: 326108
type: SpeciesReference

078009
stoichiometry: 1.0
species: 326144
type: SpeciesReference

092841
stoichiometry: 1.0
species: 326531
type: SpeciesReference

087229
stoichiometry: 1.0
species: 326233
type: SpeciesReference

111816
stoichiometry: 1.0
species: 325980
type: SpeciesReference

104277
stoichiometry: 1.0
species: 326479
type: SpeciesReference

108218
stoichiometry: 1.0
species: 326627
type: SpeciesReference

327713
kinetic law: 092925
product: 092913
reactant: 092901
fast: false
reversible: true
name: v393 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
type: Reaction

326611
notes: (MEK#P:Pase2)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_P:Pase2)_i
type: Species

094683
stoichiometry: 1.0
species: 326201
type: SpeciesReference

106486
stoichiometry: 1.0
species: 326793
type: SpeciesReference

100292
stoichiometry: 1.0
species: 326641
type: SpeciesReference

083118
stoichiometry: 1.0
species: 326459
type: SpeciesReference

326987
kinetic law: 075922
product: 075910
reactant: 075897
reactant: 075885
fast: false
reversible: true
name: v21 (EGF:ErbB1:ErbB2) + ATP -> (EGF:ErbB1:ErbB2):ATP k122 kd122
type: Reaction

084469
stoichiometry: 1.0
species: 326521
type: SpeciesReference

079503
stoichiometry: 1.0
species: 326297
type: SpeciesReference

327403
kinetic law: 085567
product: 085555
reactant: 085543
reactant: 085530
fast: false
reversible: true
name: v238 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd24
type: Reaction

098849
stoichiometry: 1.0
species: 326631
type: SpeciesReference

325962
boundary condition: false
initial concentration: NaN
in compartment: 325898
has version: P01133
has only substance units: true
constant: false
notes: EGF:ErbB1:Inh:ErB2 , plasma membrane
name: EGF:ErbB1:Inh:ErB2
initial amount: 0.0
has part: P00533
type: Species

075241
stoichiometry: 1.0
species: 325934
type: SpeciesReference

101290
stoichiometry: 1.0
species: 326329
type: SpeciesReference

327795
kinetic law: 094887
product: 094875
reactant: 094863
reactant: 094851
fast: false
reversible: true
name: v434 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

090180
stoichiometry: 1.0
species: 326241
type: SpeciesReference

328485
kinetic law: 110508
product: 110496
reactant: 110484
reactant: 110472
fast: false
reversible: true
name: v784 HRG + ErbB3 -> HRG:ErbB3 k119 kd119
type: Reaction

328327
kinetic law: 106714
product: 106702
reactant: 106690
reactant: 106678
fast: false
reversible: true
name: v705 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k106 kd106
type: Reaction

328483
kinetic law: 110460
product: 110448
reactant: 110436
reactant: 110423
fast: false
reversible: true
name: v783 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k118 kd118
type: Reaction

081403
stoichiometry: 1.0
species: 326134
type: SpeciesReference

104339
stoichiometry: 1.0
species: 326769
type: SpeciesReference

094033
stoichiometry: 1.0
species: 326505
type: SpeciesReference

096981
stoichiometry: 1.0
species: 326399
type: SpeciesReference

327401
kinetic law: 085518
product: 085506
reactant: 085494
reactant: 085482
fast: false
reversible: true
name: v237 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd63
type: Reaction

112975
stoichiometry: 1.0
species: 326941
type: SpeciesReference

326613
type: Species
has only substance units: true
in compartment: 325908
constant: false
is described by: http://identifiers.org/omim/176948
initial concentration: NaN
initial amount: 695000.0
notes: ERK , cytoplasm
boundary condition: false
name: ERK
is version of: P28482

327711
kinetic law: 092889
product: 092877
reactant: 092865
fast: false
reversible: true
name: v392 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

095513
stoichiometry: 1.0
species: 326501
type: SpeciesReference

084216
stoichiometry: 1.0
species: 326519
type: SpeciesReference

326034
notes: (HRG:ErbB4:ErbB1) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB4:ErbB1)
type: Species

089048
stoichiometry: 1.0
species: 326547
type: SpeciesReference

326985
kinetic law: 075872
product: 075859
reactant: 075846
reactant: 075833
fast: false
reversible: true
name: v20 EGF:ErbB1:ATP + ErbB3:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
type: Reaction

093140
stoichiometry: 1.0
species: 326104
type: SpeciesReference

102242
stoichiometry: 1.0
species: 326627
type: SpeciesReference

080728
stoichiometry: 1.0
species: 326219
type: SpeciesReference

102579
stoichiometry: 1.0
species: 326629
type: SpeciesReference

325960
boundary condition: false
initial concentration: NaN
name: (EGF:ErbB1:ErbB4)
has only substance units: true
has version: P01133
notes: (EGF:ErbB1:ErbB4) , endosomal membrane
constant: false
initial amount: 0.0
in compartment: 325906
has part: P00533
type: Species

111516
stoichiometry: 1.0
species: 326461
type: SpeciesReference

088808
stoichiometry: 1.0
species: 326359
type: SpeciesReference

326142
notes: (ErbB1:ErbB3)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:cPP
type: Species

328539
kinetic law: 111792
product: 111780
reactant: 111768
reactant: 111756
fast: false
reversible: true
name: v812 (ErbB1:ErbB3)#P + ATP -> EGF:ErbB1:ErbB3:ATP k123 kd123
type: Reaction

327793
kinetic law: 094839
product: 094827
reactant: 094815
reactant: 094803
fast: false
reversible: true
name: v433 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

113120
stoichiometry: 1.0
species: 326939
type: SpeciesReference

328325
kinetic law: 106666
product: 106654
reactant: 106642
reactant: 106630
fast: false
reversible: true
name: v704 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k106 kd106
type: Reaction

098091
stoichiometry: 1.0
species: 326607
type: SpeciesReference

327519
kinetic law: 088360
product: 088348
reactant: 088336
reactant: 088324
fast: false
reversible: true
name: v296 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

102458
stoichiometry: 1.0
species: 326663
type: SpeciesReference

099776
stoichiometry: 1.0
species: 326401
type: SpeciesReference

328481
kinetic law: 110411
product: 110399
reactant: 110387
reactant: 110375
fast: false
reversible: true
name: v782 Pase9t + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB1:ErbB:Gab1#P##:Pase9t k118 kd118
type: Reaction

092479
stoichiometry: 1.0
species: 326449
type: SpeciesReference

090492
stoichiometry: 1.0
species: 326347
type: SpeciesReference

077671
stoichiometry: 1.0
species: 326116
type: SpeciesReference

327491
kinetic law: 087686
product: 087674
reactant: 087662
reactant: 087650
fast: false
reversible: true
name: v282 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

326140
notes: (ErbB1:ErbB3)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2
type: Species

091120
stoichiometry: 1.0
species: 326201
type: SpeciesReference

102978
stoichiometry: 1.0
species: 326701
type: SpeciesReference

326479
notes: (ErbB4:ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P
type: Species

326615
notes: ERK:MEK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK:MEK_PP
type: Species

326036
notes: (HRG:ErbB4:ErbB1):ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (HRG:ErbB4:ErbB1):ATP
type: Species

328071
kinetic law: 100917
product: 100905
reactant: 100892
fast: false
reversible: true
name: v576 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

086508
stoichiometry: 1.0
species: 326411
type: SpeciesReference

081550
stoichiometry: 1.0
species: 326122
type: SpeciesReference

076717
stoichiometry: 1.0
species: 325980
type: SpeciesReference

096668
stoichiometry: 1.0
species: 326539
type: SpeciesReference

326983
kinetic law: 075819
product: 075806
reactant: 075793
reactant: 075779
fast: false
reversible: true
name: v19 EGF:ErbB1:ATP + ErbB4:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
type: Reaction

090071
stoichiometry: 1.0
species: 326217
type: SpeciesReference

109194
stoichiometry: 1.0
species: 326705
type: SpeciesReference

111300
stoichiometry: 1.0
species: 326925
type: SpeciesReference

326769
notes: (ErbB1:ErbB2)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:RTK_Pase
type: Species

326144
notes: (ErbB1:ErbB4)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2
type: Species

327931
kinetic law: 098151
product: 098139
reactant: 098127
reactant: 098115
fast: false
reversible: true
name: v502 MEK + Pase2 -> MEK#P:Pase2 k49 kd49
type: Reaction

329385
constant: true
value: 0.0
name: k123
type: Parameter

081781
stoichiometry: 1.0
species: 326399
type: SpeciesReference

094960
stoichiometry: 1.0
species: 326577
type: SpeciesReference

108556
stoichiometry: 1.0
species: 326629
type: SpeciesReference

W3 CDTF: Thu Sep 08 12:47:19 BST 2011

326030
notes: (HRG:ErbB3:ErbB1) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB3:ErbB1)
type: Species

104628
stoichiometry: 1.0
species: 326765
type: SpeciesReference

329307
constant: true
value: 0.1
name: kd105
type: Parameter

328375
kinetic law: 107870
product: 107858
reactant: 107846
reactant: 107834
fast: false
reversible: true
name: v729 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k110 kd110
type: Reaction

326981
kinetic law: 075766
product: 075753
reactant: 075740
reactant: 075727
fast: false
reversible: true
name: v18 EGF:ErbB1:ATP + ErbB2:Inh -> (EGF:ErbB1:ErbB2):Inh k2b kd2b
type: Reaction

328073
kinetic law: 100953
product: 100941
reactant: 100929
fast: false
reversible: true
name: v577 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

086135
stoichiometry: 1.0
species: 326205
type: SpeciesReference

111336
stoichiometry: 1.0
species: 325980
type: SpeciesReference

328219
kinetic law: 104108
product: 104096
reactant: 104084
reactant: 104072
fast: false
reversible: true
name: v651 RTK_Pase + (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P:RTK_Pase k94b kd94
type: Reaction

082225
stoichiometry: 1.0
species: 326066
type: SpeciesReference

084107
stoichiometry: 1.0
species: 326493
type: SpeciesReference

078839
stoichiometry: 1.0
species: 326056
type: SpeciesReference

105714
stoichiometry: 1.0
species: 325938
type: SpeciesReference

W3 CDTF: Mon Jul 26 18:39:07 BST 2010

096872
stoichiometry: 1.0
species: 326529
type: SpeciesReference

101181
stoichiometry: 1.0
species: 326339
type: SpeciesReference

326082
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

096042
stoichiometry: 1.0
species: 326499
type: SpeciesReference

087962
stoichiometry: 1.0
species: 326345
type: SpeciesReference

086616
stoichiometry: 1.0
species: 326116
type: SpeciesReference

111480
stoichiometry: 1.0
species: 325980
type: SpeciesReference

096776
stoichiometry: 1.0
species: 326439
type: SpeciesReference

327933
kinetic law: 098199
product: 098187
reactant: 098175
reactant: 098163
fast: false
reversible: true
name: v503 MEK + Pase2 -> (MEK#P:Pase2)_i k49 kd49
type: Reaction

089156
stoichiometry: 1.0
species: 326277
type: SpeciesReference

087662
stoichiometry: 1.0
species: 326321
type: SpeciesReference

089204
stoichiometry: 1.0
species: 326325
type: SpeciesReference

326146
notes: (ErbB1:ErbB4)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:cPP
type: Species

329305
notes: %Gab1 association
constant: true
value: 6.67E-5
name: k105
type: Parameter

098380
stoichiometry: 1.0
species: 326615
type: SpeciesReference

092589
stoichiometry: 1.0
species: 326459
type: SpeciesReference

082936
stoichiometry: 1.0
species: 326443
type: SpeciesReference

082864
stoichiometry: 1.0
species: 325950
type: SpeciesReference

102688
stoichiometry: 1.0
species: 326683
type: SpeciesReference

109255
stoichiometry: 1.0
species: 326863
type: SpeciesReference

077961
stoichiometry: 1.0
species: 326140
type: SpeciesReference

328373
kinetic law: 107822
product: 107810
reactant: 107798
reactant: 107786
fast: false
reversible: true
name: v728 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
type: Reaction

328217
kinetic law: 104060
product: 104048
reactant: 104036
reactant: 104024
fast: false
reversible: true
name: v650 RTK_Pase + (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P:RTK_Pase k94b kd94
type: Reaction

076826
stoichiometry: 1.0
species: 326044
type: SpeciesReference

098429
stoichiometry: 1.0
species: 326619
type: SpeciesReference

328075
kinetic law: 100989
product: 100977
reactant: 100965
fast: false
reversible: true
name: v579 (ErbB3:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60
type: Reaction

091096
stoichiometry: 1.0
species: 326383
type: SpeciesReference

326032
notes: (HRG:ErbB3:ErbB1):ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (HRG:ErbB3:ErbB1):ATP
type: Species

329387
constant: true
value: 0.177828
name: kd123
type: Parameter

080776
stoichiometry: 1.0
species: 326215
type: SpeciesReference

326084
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

101518
stoichiometry: 1.0
species: 326641
type: SpeciesReference

093356
stoichiometry: 1.0
species: 326539
type: SpeciesReference

329381
constant: true
value: 1.0
name: kd121
type: Parameter

327499
kinetic law: 087878
product: 087866
reactant: 087854
reactant: 087842
fast: false
reversible: true
name: v286 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

327513
kinetic law: 088215
product: 088203
reactant: 088191
reactant: 088179
fast: false
reversible: true
name: v293 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326148
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

326833
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P_ERK_PP
type: Species

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

099464
stoichiometry: 1.0
species: 326641
type: SpeciesReference

084974
stoichiometry: 1.0
species: 326405
type: SpeciesReference

090688
stoichiometry: 1.0
species: 326421
type: SpeciesReference

326331
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

076031
stoichiometry: 1.0
species: 325936
type: SpeciesReference

106594
stoichiometry: 1.0
species: 326721
type: SpeciesReference

326765
notes: (ErbB2:ErbB3)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB2:ErbB3)_P:RTK_Pase
type: Species

080945
stoichiometry: 1.0
species: 326309
type: SpeciesReference

328153
kinetic law: 102518
product: 102506
reactant: 102494
reactant: 102482
fast: false
reversible: true
name: v618 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
type: Reaction

328079
kinetic law: 101061
product: 101049
reactant: 101037
fast: false
reversible: true
name: v581 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
type: Reaction

077453
stoichiometry: 1.0
species: 326098
type: SpeciesReference

106870
stoichiometry: 1.0
species: 326805
type: SpeciesReference

092697
stoichiometry: 1.0
species: 326439
type: SpeciesReference

102025
stoichiometry: 1.0
species: 326641
type: SpeciesReference

329303
notes: %PIP2 dissociates from PTEN
constant: true
value: 0.2
name: kd104
type: Parameter

112105
stoichiometry: 1.0
species: 326699
type: SpeciesReference

328077
kinetic law: 101025
product: 101013
reactant: 101001
fast: false
reversible: true
name: v580 (ErbB4:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60
type: Reaction

109038
stoichiometry: 1.0
species: 326541
type: SpeciesReference

110592
stoichiometry: 1.0
species: 326042
type: SpeciesReference

328429
kinetic law: 109170
product: 109158
reactant: 109146
reactant: 109134
fast: false
reversible: true
name: v756 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
type: Reaction

328379
kinetic law: 107966
product: 107954
reactant: 107942
reactant: 107930
fast: false
reversible: true
name: v731 ERK#P#P + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
type: Reaction

327409
kinetic law: 085711
product: 085699
reactant: 085687
reactant: 085675
fast: false
reversible: true
name: v241 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

112210
stoichiometry: 1.0
species: 326679
type: SpeciesReference

083685
stoichiometry: 1.0
species: 326429
type: SpeciesReference

328215
kinetic law: 104012
product: 104000
reactant: 103988
reactant: 103976
fast: false
reversible: true
name: v649 PDK1 + PIP3 -> PIP3:PDK1 k76 kd76
type: Reaction

107738
stoichiometry: 1.0
species: 326627
type: SpeciesReference

106690
stoichiometry: 1.0
species: 326725
type: SpeciesReference

329383
constant: false
value: 1.0
name: kd122
type: Parameter

110928
stoichiometry: 1.0
species: 326649
type: SpeciesReference

086496
stoichiometry: 1.0
species: 326541
type: SpeciesReference

083805
stoichiometry: 1.0
species: 326469
type: SpeciesReference

084577
stoichiometry: 1.0
species: 326503
type: SpeciesReference

326767
notes: (ErbB2:ErbB4)#P:RTK_Pase , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB2:ErbB4)_P:RTK_Pase
type: Species

083516
stoichiometry: 1.0
species: 326467
type: SpeciesReference

327511
kinetic law: 088166
product: 088154
reactant: 088142
reactant: 088130
fast: false
reversible: true
name: v292 (Ras:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

075181
stoichiometry: 1.0
species: 325914
type: SpeciesReference

082129
stoichiometry: 1.0
species: 326074
type: SpeciesReference

098645
stoichiometry: 1.0
species: 326627
type: SpeciesReference

326831
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:ERK_PP_i
type: Species

328151
kinetic law: 102470
product: 102458
reactant: 102446
reactant: 102434
fast: false
reversible: true
name: v617 ERK#P#P + Sos#P -> (ERK#P#P):Sos k65 kd65
type: Reaction

105449
stoichiometry: 1.0
species: 325920
type: SpeciesReference

078983
stoichiometry: 1.0
species: 326056
type: SpeciesReference

110880
stoichiometry: 1.0
species: 326647
type: SpeciesReference

092733
stoichiometry: 1.0
species: 326437
type: SpeciesReference

329301
constant: true
value: 0.0
name: k104
type: Parameter

094141
stoichiometry: 1.0
species: 326575
type: SpeciesReference

328427
kinetic law: 109122
product: 109110
reactant: 109098
reactant: 109086
fast: false
reversible: true
name: v755 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
type: Reaction

083009
stoichiometry: 1.0
species: 326451
type: SpeciesReference

078118
stoichiometry: 1.0
species: 326056
type: SpeciesReference

079612
stoichiometry: 1.0
species: 326056
type: SpeciesReference

089365
stoichiometry: 1.0
species: 326197
type: SpeciesReference

088480
stoichiometry: 1.0
species: 326545
type: SpeciesReference

327407
kinetic law: 085663
product: 085651
reactant: 085639
reactant: 085627
fast: false
reversible: true
name: v240 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd63
type: Reaction

087434
stoichiometry: 1.0
species: 326257
type: SpeciesReference

328377
kinetic law: 107918
product: 107906
reactant: 107894
reactant: 107882
fast: false
reversible: true
name: v730 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
type: Reaction

328213
kinetic law: 103964
product: 103952
reactant: 103940
reactant: 103928
fast: false
reversible: true
name: v648 AKT#P + Pase4 -> AKT#P#P:Pase4 k75 kd75
type: Reaction

087024
stoichiometry: 1.0
species: 326541
type: SpeciesReference

075833
stoichiometry: 1.0
species: 325914
type: SpeciesReference

106942
stoichiometry: 1.0
species: 326813
type: SpeciesReference

090456
stoichiometry: 1.0
species: 326541
type: SpeciesReference

101229
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326080
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

105593
stoichiometry: 1.0
species: 326783
type: SpeciesReference

108327
stoichiometry: 1.0
species: 326851
type: SpeciesReference

097126
stoichiometry: 1.0
species: 326217
type: SpeciesReference

081635
stoichiometry: 1.0
species: 326393
type: SpeciesReference

092503
stoichiometry: 1.0
species: 326443
type: SpeciesReference

076619
stoichiometry: 1.0
species: 325980
type: SpeciesReference

101073
stoichiometry: 1.0
species: 326459
type: SpeciesReference

111108
stoichiometry: 1.0
species: 326913
type: SpeciesReference

329167
constant: true
value: 1.67E-5
name: k64
type: Parameter

329235
constant: true
value: 0.01
name: kd94
type: Parameter

082719
stoichiometry: 1.0
species: 326409
type: SpeciesReference

112429
stoichiometry: 1.0
species: 325980
type: SpeciesReference

081185
stoichiometry: 1.0
species: 326309
type: SpeciesReference

091722
stoichiometry: 1.0
species: 326305
type: SpeciesReference

096440
stoichiometry: 1.0
species: 326523
type: SpeciesReference

090396
stoichiometry: 1.0
species: 326321
type: SpeciesReference

099176
stoichiometry: 1.0
species: 326641
type: SpeciesReference

097922
stoichiometry: 1.0
species: 326571
type: SpeciesReference

327635
kinetic law: 091204
product: 091192
reactant: 091180
reactant: 091168
fast: false
reversible: true
name: v354 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

100784
stoichiometry: 1.0
species: 326351
type: SpeciesReference

328437
kinetic law: 109363
product: 109351
reactant: 109339
reactant: 109327
fast: false
reversible: true
name: v760 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
type: Reaction

328157
kinetic law: 102615
product: 102603
reactant: 102591
reactant: 102579
fast: false
reversible: true
name: v620 (ERK#P#P)_i + Sos#P -> ((ERK#P#P):Sos)_i k65 kd65
type: Reaction

079576
stoichiometry: 1.0
species: 326303
type: SpeciesReference

104072
stoichiometry: 1.0
species: 326755
type: SpeciesReference

112001
stoichiometry: 1.0
species: 326683
type: SpeciesReference

085832
stoichiometry: 1.0
species: 326323
type: SpeciesReference

075623
stoichiometry: 1.0
species: 325942
type: SpeciesReference

327381
kinetic law: 085035
product: 085023
reactant: 085010
reactant: 084998
fast: false
reversible: true
name: v227 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

105931
stoichiometry: 1.0
species: 326002
type: SpeciesReference

094815
stoichiometry: 1.0
species: 326577
type: SpeciesReference

113239
stoichiometry: 1.0
species: 326425
type: SpeciesReference

081281
stoichiometry: 1.0
species: 326309
type: SpeciesReference

327939
kinetic law: 098344
product: 098332
reactant: 098320
reactant: 098308
fast: false
reversible: true
name: v506 Pase2 + MEK#P -> MEK#P:Pase2 k50 kd50
type: Reaction

327869
kinetic law: 096656
product: 096644
reactant: 096632
reactant: 096620
fast: false
reversible: true
name: v471 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

088686
stoichiometry: 1.0
species: 326156
type: SpeciesReference

095621
stoichiometry: 1.0
species: 326523
type: SpeciesReference

328961
constant: true
value: 0.16
name: kd2
type: Parameter

326269
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

326837
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP
type: Species

326323
notes: (ErbB4:ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Grb2
type: Species

080320
stoichiometry: 1.0
species: 326309
type: SpeciesReference

092334
stoichiometry: 1.0
species: 326511
type: SpeciesReference

087518
stoichiometry: 1.0
species: 326289
type: SpeciesReference

329169
constant: true
value: 0.3
name: kd64
type: Parameter

329233
constant: true
value: 5.0E-5
name: k94
type: Parameter

096114
stoichiometry: 1.0
species: 326489
type: SpeciesReference

082647
stoichiometry: 1.0
species: 326413
type: SpeciesReference

108748
stoichiometry: 1.0
species: 326629
type: SpeciesReference

328155
kinetic law: 102567
product: 102555
reactant: 102543
reactant: 102531
fast: false
reversible: true
name: v619 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k65 kd65
type: Reaction

100832
stoichiometry: 1.0
species: 326641
type: SpeciesReference

076103
stoichiometry: 1.0
species: 325990
type: SpeciesReference

090604
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328435
kinetic law: 109315
product: 109303
reactant: 109291
reactant: 109279
fast: false
reversible: true
name: v759 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
type: Reaction

075470
stoichiometry: 1.0
species: 325934
type: SpeciesReference

109471
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327633
kinetic law: 091156
product: 091144
reactant: 091132
reactant: 091120
fast: false
reversible: true
name: v353 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

102821
stoichiometry: 1.0
species: 326677
type: SpeciesReference

107593
stoichiometry: 1.0
species: 326629
type: SpeciesReference

109687
stoichiometry: 1.0
species: 326877
type: SpeciesReference

327383
kinetic law: 085085
product: 085072
reactant: 085059
reactant: 085047
fast: false
reversible: true
name: v228 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

107231
stoichiometry: 1.0
species: 326811
type: SpeciesReference

108122
stoichiometry: 1.0
species: 326627
type: SpeciesReference

099992
stoichiometry: 1.0
species: 326389
type: SpeciesReference

077067
stoichiometry: 1.0
species: 326066
type: SpeciesReference

077816
stoichiometry: 1.0
species: 326128
type: SpeciesReference

327867
kinetic law: 096608
product: 096596
reactant: 096584
reactant: 096572
fast: false
reversible: true
name: v470 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

329231
constant: true
value: 5.0E-5
name: k94b
type: Parameter

326835
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:ERK_PP_i
type: Species

100148
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326321
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2:Sos
type: Species

084758
stoichiometry: 1.0
species: 326499
type: SpeciesReference

101724
stoichiometry: 1.0
species: 325952
type: SpeciesReference

097357
stoichiometry: 1.0
species: 326459
type: SpeciesReference

106726
stoichiometry: 1.0
species: 326793
type: SpeciesReference

080476
stoichiometry: 1.0
species: 326345
type: SpeciesReference

329239
constant: true
value: 33.0
name: kd95
type: Parameter

326086
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

BIOMD0000000255
reaction: 327471
reaction: 328109
parameter: 329201
reaction: 328055
reaction: 326997
parameter: 329179
reaction: 327611
parameter: 329341
reaction: 327785
reaction: 328421
reaction: 328369
reaction: 327523
species: 325998
species: 326094
species: 326301
species: 326649
reaction: 327569
parameter: 328943
parameter: 329053
species: 326357
reaction: 328169
reaction: 327969
reaction: 328489
reaction: 327263
reaction: 328073
reaction: 327637
reaction: 327027
species: 326773
reaction: 328213
species: 326108
rule: 328912
reaction: 327311
reaction: 328533
parameter: 329143
species: 326213
reaction: 328473
species: 326423
reaction: 327571
species: 326701
reaction: 327297
parameter: 329351
species: 326078
reaction: 328521
reaction: 327383
species: 326545
units def: 074830
species: 326223
reaction: 327987
reaction: 327435
reaction: 327341
species: 326817
parameter: 328953
reaction: 328019
reaction: 328593
parameter: 329389
parameter: 329305
parameter: 329025
reaction: 327741
species: 326685
reaction: 327131
reaction: 328551
reaction: 328325
parameter: 329165
reaction: 327685
reaction: 327075
function def: 328925
species: 326869
parameter: 329123
reaction: 327235
reaction: 328045
species: 326203
species: 326917
parameter: 329225
parameter: 329119
reaction: 327861
reaction: 328445
reaction: 327163
parameter: 329195
species: 326325
reaction: 327913

329389
constant: true
value: 0.0
name: k6b
type: Parameter

088976
stoichiometry: 1.0
species: 326261
type: SpeciesReference

077309
stoichiometry: 1.0
species: 326086
type: SpeciesReference

103519
stoichiometry: 1.0
species: 326733
type: SpeciesReference

327385
kinetic law: 085133
product: 085121
reactant: 085109
reactant: 085097
fast: false
reversible: true
name: v229 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

084902
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327631
kinetic law: 091108
product: 091096
reactant: 091084
reactant: 091072
fast: false
reversible: true
name: v352 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

089522
stoichiometry: 1.0
species: 326365
type: SpeciesReference

328433
kinetic law: 109267
product: 109255
reactant: 109243
reactant: 109231
fast: false
reversible: true
name: v758 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k113 kd113
type: Reaction

086856
stoichiometry: 1.0
species: 326148
type: SpeciesReference

110387
stoichiometry: 1.0
species: 326687
type: SpeciesReference

099884
stoichiometry: 1.0
species: 326395
type: SpeciesReference

107882
stoichiometry: 1.0
species: 326629
type: SpeciesReference

328371
kinetic law: 107774
product: 107762
reactant: 107750
reactant: 107738
fast: false
reversible: true
name: v727 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
type: Reaction

110664
stoichiometry: 1.0
species: 325938
type: SpeciesReference

104749
stoichiometry: 1.0
species: 326773
type: SpeciesReference

104132
stoichiometry: 1.0
species: 326427
type: SpeciesReference

328965
constant: true
value: 0.016
name: kd2b
type: Parameter

326401
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2
type: Species

326265
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

079792
stoichiometry: 1.0
species: 326309
type: SpeciesReference

329163
constant: true
value: 0.0
name: kd61
type: Parameter

076487
stoichiometry: 1.0
species: 326016
type: SpeciesReference

326327
notes: (ErbB3:ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Grb2
type: Species

110375
stoichiometry: 1.0
species: 326885
type: SpeciesReference

105013
stoichiometry: 1.0
species: 326673
type: SpeciesReference

327935
kinetic law: 098248
product: 098235
reactant: 098223
reactant: 098211
fast: false
reversible: true
name: v504 (MEK#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k49 kd49
type: Reaction

111192
stoichiometry: 1.0
species: 326919
type: SpeciesReference

082021
stoichiometry: 1.0
species: 326409
type: SpeciesReference

113047
stoichiometry: 1.0
species: 326935
type: SpeciesReference

329237
constant: true
value: 0.0
name: k95
type: Parameter

094899
stoichiometry: 1.0
species: 326499
type: SpeciesReference

095826
stoichiometry: 1.0
species: 326088
type: SpeciesReference

085724
stoichiometry: 1.0
species: 326539
type: SpeciesReference

328209
kinetic law: 103868
product: 103856
reactant: 103844
reactant: 103832
fast: false
reversible: true
name: v646 AKT#P + Pase4 -> AKT#P:Pase4 k73 kd73
type: Reaction

327387
kinetic law: 085181
product: 085169
reactant: 085157
reactant: 085145
fast: false
reversible: true
name: v230 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

092286
stoichiometry: 1.0
species: 326507
type: SpeciesReference

326559
notes: (ErbB1:ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Shc
type: Species

328159
kinetic law: 102664
product: 102651
reactant: 102639
reactant: 102627
fast: false
reversible: true
name: v621 PI3K + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
type: Reaction

328431
kinetic law: 109219
product: 109206
reactant: 109194
reactant: 109182
fast: false
reversible: true
name: v757 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
type: Reaction

097272
stoichiometry: 1.0
species: 326325
type: SpeciesReference

107508
stoichiometry: 1.0
species: 326791
type: SpeciesReference

085675
stoichiometry: 1.0
species: 326539
type: SpeciesReference

109711
stoichiometry: 1.0
species: 326881
type: SpeciesReference

091613
stoichiometry: 1.0
species: 326541
type: SpeciesReference

105376
stoichiometry: 1.0
species: 325938
type: SpeciesReference

326267
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

326325
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

329165
constant: true
value: 0.275
name: kd63
type: Parameter

326839
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i
type: Species

326088
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

328963
constant: true
value: 3.73632E-8
name: k2b
type: Parameter

095970
stoichiometry: 1.0
species: 326405
type: SpeciesReference

079840
stoichiometry: 1.0
species: 326309
type: SpeciesReference

327937
kinetic law: 098296
product: 098284
reactant: 098272
reactant: 098260
fast: false
reversible: true
name: v505 Pase2 + (MEK#P)_i -> (MEK#P:Pase2)_i k50 kd50
type: Reaction

078322
stoichiometry: 1.0
species: 326199
type: SpeciesReference

327039
kinetic law: 077177
product: 077165
reactant: 077153
reactant: 077140
fast: false
reversible: true
name: v47 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k4 kd4
type: Reaction

096908
stoichiometry: 1.0
species: 326577
type: SpeciesReference

099236
stoichiometry: 1.0
species: 326419
type: SpeciesReference

329099
constant: true
value: 0.0429
name: kd41
type: Parameter

326557
notes: (ErbB1:ErbB4)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Shc
type: Species

326489
notes: 2(ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P)
type: Species

326617
notes: ERK#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_P
type: Species

076331
stoichiometry: 1.0
species: 325980
type: SpeciesReference

327389
kinetic law: 085229
product: 085217
reactant: 085205
reactant: 085193
fast: false
reversible: true
name: v231 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63
type: Reaction

110772
stoichiometry: 1.0
species: 325912
type: SpeciesReference

075519
stoichiometry: 1.0
species: 325934
type: SpeciesReference

087914
stoichiometry: 1.0
species: 326237
type: SpeciesReference

329005
constant: true
value: 0.011
name: kd10
type: Parameter

107666
stoichiometry: 1.0
species: 326825
type: SpeciesReference

094513
stoichiometry: 1.0
species: 326523
type: SpeciesReference

328541
kinetic law: 111840
product: 111828
reactant: 111816
reactant: 111804
fast: false
reversible: true
name: v813 (ErbB1:ErbB4)#P + ATP -> EGF:ErbB1:ErbB4:ATP k123 kd123
type: Reaction

327037
kinetic law: 077127
product: 077115
reactant: 077103
reactant: 077091
fast: false
reversible: true
name: v46 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
type: Reaction

090832
stoichiometry: 1.0
species: 326100
type: SpeciesReference

326405
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

328969
constant: true
value: 0.001
name: kd3
type: Parameter

107015
stoichiometry: 1.0
species: 326805
type: SpeciesReference

094369
stoichiometry: 1.0
species: 326511
type: SpeciesReference

099524
stoichiometry: 1.0
species: 326409
type: SpeciesReference

328319
kinetic law: 106522
product: 106510
reactant: 106498
reactant: 106486
fast: false
reversible: true
name: v701 PIP2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> PI3K k106 kd106
type: Reaction

327277
kinetic law: 082767
product: 082755
reactant: 082743
fast: false
reversible: true
name: v174 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k6 kd6
type: Reaction

075597
stoichiometry: 1.0
species: 325962
type: SpeciesReference

327861
kinetic law: 096464
product: 096452
reactant: 096440
reactant: 096428
fast: false
reversible: true
name: v467 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

327787
kinetic law: 094695
product: 094683
reactant: 094671
reactant: 094659
fast: false
reversible: true
name: v430 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

093644
stoichiometry: 1.0
species: 326543
type: SpeciesReference

100208
stoichiometry: 1.0
species: 326377
type: SpeciesReference

095201
stoichiometry: 1.0
species: 326577
type: SpeciesReference

080668
stoichiometry: 1.0
species: 326353
type: SpeciesReference

325966
has version: P01133
constant: false
in compartment: 325898
initial concentration: NaN
type: Species
boundary condition: false
notes: EGF:ErbB1:Inh:ErB4 , plasma membrane
has part: P00533
initial amount: 0.0
has only substance units: true
name: EGF:ErbB1:Inh:ErB4

108966
stoichiometry: 1.0
species: 326865
type: SpeciesReference

095141
stoichiometry: 1.0
species: 326509
type: SpeciesReference

106268
stoichiometry: 1.0
species: 326715
type: SpeciesReference

111961
stoichiometry: 1.0
species: 325980
type: SpeciesReference

078214
stoichiometry: 1.0
species: 326056
type: SpeciesReference

329097
constant: true
value: 5.0E-5
name: k41
type: Parameter

090988
stoichiometry: 1.0
species: 326541
type: SpeciesReference

326555
notes: (ErbB1:ErbB3)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Shc
type: Species

326619
notes: ERK#P:MEK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_P:MEK_PP
type: Species

326487
notes: 2(ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Shc
type: Species

112759
stoichiometry: 1.0
species: 326921
type: SpeciesReference

076559
stoichiometry: 1.0
species: 326022
type: SpeciesReference

326261
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

108436
stoichiometry: 1.0
species: 326833
type: SpeciesReference

104857
stoichiometry: 1.0
species: 326775
type: SpeciesReference

103026
stoichiometry: 1.0
species: 326697
type: SpeciesReference

093717
stoichiometry: 1.0
species: 326569
type: SpeciesReference

080044
stoichiometry: 1.0
species: 326327
type: SpeciesReference

094465
stoichiometry: 1.0
species: 326513
type: SpeciesReference

329003
constant: true
value: 0.05426
name: k10b
type: Parameter

085350
stoichiometry: 1.0
species: 326451
type: SpeciesReference

326403
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2
type: Species

327035
kinetic law: 077079
product: 077067
reactant: 077055
reactant: 077043
fast: false
reversible: true
name: v45 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4 kd4
type: Reaction

328967
constant: true
value: 1.0
name: k3
type: Parameter

088154
stoichiometry: 1.0
species: 326417
type: SpeciesReference

091902
stoichiometry: 1.0
species: 326501
type: SpeciesReference

329001
constant: true
value: 140000.0
name: k10
type: Parameter

112079
stoichiometry: 1.0
species: 326016
type: SpeciesReference

326329
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

328269
kinetic law: 105315
product: 105303
reactant: 105291
reactant: 105279
fast: false
reversible: true
name: v676 EGF:ErbB1#P + ErbB4#P -> (ErbB1:ErbB4)#P k102 kd102
type: Reaction

327785
kinetic law: 094647
product: 094634
reactant: 094622
reactant: 094610
fast: false
reversible: true
name: v429 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

328317
kinetic law: 106474
product: 106461
reactant: 106449
reactant: 106437
fast: false
reversible: true
name: v700 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106
type: Reaction

327279
kinetic law: 082804
product: 082792
reactant: 082780
fast: false
reversible: true
name: v175 2(EGF:ErbB1)#P:GAP:Grb2 + -> 2(EGF:ErbB1)#P:GAP:Grb2 k6 kd6
type: Reaction

326263
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

329161
constant: true
value: 5.7E-4
name: k61
type: Parameter

103038
stoichiometry: 1.0
species: 326711
type: SpeciesReference

098741
stoichiometry: 1.0
species: 326627
type: SpeciesReference

091504
stoichiometry: 1.0
species: 326253
type: SpeciesReference

097065
stoichiometry: 1.0
species: 326537
type: SpeciesReference

325964
has version: P01133
in compartment: 325898
constant: false
initial concentration: NaN
name: EGF:ErbB1:Inh:ErB3
notes: EGF:ErbB1:Inh:ErB3 , plasma membrane
boundary condition: false
has part: P00533
type: Species
has only substance units: true
initial amount: 0.0

326553
notes: (ErbB1:ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Shc
type: Species

079467
stoichiometry: 1.0
species: 326056
type: SpeciesReference

326485
notes: 2(ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Shc
type: Species

098909
stoichiometry: 1.0
species: 326633
type: SpeciesReference

329095
constant: true
value: 0.064
name: kd40
type: Parameter

327719
kinetic law: 093056
product: 093044
reactant: 093032
reactant: 093020
fast: false
reversible: true
name: v396 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

327639
kinetic law: 091300
product: 091288
reactant: 091276
reactant: 091264
fast: false
reversible: true
name: v356 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

081330
stoichiometry: 1.0
species: 326309
type: SpeciesReference

091998
stoichiometry: 1.0
species: 326505
type: SpeciesReference

083191
stoichiometry: 1.0
species: 326467
type: SpeciesReference

327031
kinetic law: 076983
product: 076971
reactant: 076959
reactant: 076947
fast: false
reversible: true
name: v43 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k4 kd4
type: Reaction

104484
stoichiometry: 1.0
species: 326759
type: SpeciesReference

103363
stoichiometry: 1.0
species: 326723
type: SpeciesReference

329009
constant: true
value: 0.0
name: kd13
type: Parameter

327271
kinetic law: 082659
product: 082647
reactant: 082635
fast: false
reversible: true
name: v171 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k6 kd6
type: Reaction

089315
stoichiometry: 1.0
species: 326193
type: SpeciesReference

097609
stoichiometry: 1.0
species: 326587
type: SpeciesReference

327865
kinetic law: 096560
product: 096548
reactant: 096536
reactant: 096524
fast: false
reversible: true
name: v469 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

085942
stoichiometry: 1.0
species: 326347
type: SpeciesReference

110436
stoichiometry: 1.0
species: 326703
type: SpeciesReference

077115
stoichiometry: 1.0
species: 326070
type: SpeciesReference

326409
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

328545
kinetic law: 111936
product: 111924
reactant: 111912
reactant: 111900
fast: false
reversible: true
name: v815 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
type: Reaction

328267
kinetic law: 105267
product: 105255
reactant: 105243
reactant: 105231
fast: false
reversible: true
name: v675 EGF:ErbB1#P + ErbB3#P -> (ErbB1:ErbB3)#P k102 kd102
type: Reaction

327033
kinetic law: 077031
product: 077019
reactant: 077007
reactant: 076995
fast: false
reversible: true
name: v44 2(EGF:ErbB1)#P:GAP:Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k4 kd4
type: Reaction

096198
stoichiometry: 1.0
species: 326525
type: SpeciesReference

086592
stoichiometry: 1.0
species: 326541
type: SpeciesReference

090348
stoichiometry: 1.0
species: 326285
type: SpeciesReference

112576
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326551
boundary condition: false
is version of: P98077
name: Shc
initial amount: 1100000.0
in compartment: 325908
is described by: http://identifiers.org/omim/605217
type: Species
notes: Shc , cytoplasm
constant: false
has only substance units: true
initial concentration: NaN

326483
notes: 2(ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP
type: Species

101398
stoichiometry: 1.0
species: 326321
type: SpeciesReference

077526
stoichiometry: 1.0
species: 326104
type: SpeciesReference

327717
kinetic law: 093008
product: 092996
reactant: 092984
reactant: 092973
fast: false
reversible: true
name: v395 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

100941
stoichiometry: 1.0
species: 326641
type: SpeciesReference

329093
constant: true
value: 5.0E-5
name: k40
type: Parameter

327637
kinetic law: 091252
product: 091240
reactant: 091228
reactant: 091216
fast: false
reversible: true
name: v355 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

085242
stoichiometry: 1.0
species: 326483
type: SpeciesReference

329007
constant: true
value: 0.0
name: k13
type: Parameter

328263
kinetic law: 105171
product: 105159
reactant: 105146
reactant: 105134
fast: false
reversible: true
name: v673 EGF:ErbB1#P + EGF:ErbB1#P -> 2(EGF:ErbB1)#P k102 kd102
type: Reaction

091552
stoichiometry: 1.0
species: 326337
type: SpeciesReference

096380
stoichiometry: 1.0
species: 326509
type: SpeciesReference

109795
stoichiometry: 1.0
species: 326885
type: SpeciesReference

327273
kinetic law: 082695
product: 082683
reactant: 082671
fast: false
reversible: true
name: v172 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k6 kd6
type: Reaction

089265
stoichiometry: 1.0
species: 326189
type: SpeciesReference

327275
kinetic law: 082731
product: 082719
reactant: 082707
fast: false
reversible: true
name: v173 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k6 kd6
type: Reaction

101302
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327863
kinetic law: 096512
product: 096500
reactant: 096488
reactant: 096476
fast: false
reversible: true
name: v468 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

078682
stoichiometry: 1.0
species: 326229
type: SpeciesReference

328265
kinetic law: 105219
product: 105207
reactant: 105195
reactant: 105183
fast: false
reversible: true
name: v674 ErbB2#P + EGF:ErbB1#P -> (ErbB1:ErbB2)#P k102 kd102
type: Reaction

327789
kinetic law: 094743
product: 094731
reactant: 094719
reactant: 094707
fast: false
reversible: true
name: v431 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

326407
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

328543
kinetic law: 111888
product: 111876
reactant: 111864
reactant: 111852
fast: false
reversible: true
name: v814 2(ErbB2)#P + ATP -> ErbB2:ErbB2#P:ATP k123 kd123
type: Reaction

103471
stoichiometry: 1.0
species: 326729
type: SpeciesReference

325968
notes: ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB2:Inh
type: Species

326481
notes: 2(ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP
type: Species

091336
stoichiometry: 1.0
species: 326367
type: SpeciesReference

098223
stoichiometry: 1.0
species: 326603
type: SpeciesReference

087361
stoichiometry: 1.0
species: 326541
type: SpeciesReference

327485
kinetic law: 087542
product: 087530
reactant: 087518
reactant: 087506
fast: false
reversible: true
name: v279 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

086423
stoichiometry: 1.0
species: 326080
type: SpeciesReference

086279
stoichiometry: 1.0
species: 326361
type: SpeciesReference

086351
stoichiometry: 1.0
species: 326541
type: SpeciesReference

088384
stoichiometry: 1.0
species: 326543
type: SpeciesReference

328499
kinetic law: 110844
product: 110832
reactant: 110820
reactant: 110808
fast: false
reversible: true
name: v791 + (HRG:ErbB4) -> k120 kd120
type: Reaction

326775
type: Species
constant: false
notes: Inh , medium
name: Inh
initial amount: NaN
has only substance units: false
is version of: CHEBI:49603
in compartment: 325904
initial concentration: 0.0
substance units: mole
boundary condition: true
is version of: GO:0030293

327503
kinetic law: 087974
product: 087962
reactant: 087950
reactant: 087938
fast: false
reversible: true
name: v288 (Ras:GTP)_i + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

111672
stoichiometry: 1.0
species: 325980
type: SpeciesReference

085458
stoichiometry: 1.0
species: 326339
type: SpeciesReference

328523
kinetic law: 111408
product: 111396
reactant: 111384
reactant: 111372
fast: false
reversible: true
name: v804 2(EGF:ErbB1)#P + ATP -> k123 kd123
type: Reaction

087217
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328271
kinetic law: 105364
product: 105352
reactant: 105340
reactant: 105327
fast: false
reversible: true
name: v677 ErbB2#P + ErbB2 -> ErbB2:ErbB2#P k103 kd103
type: Reaction

111804
stoichiometry: 1.0
species: 326469
type: SpeciesReference

104289
stoichiometry: 1.0
species: 326767
type: SpeciesReference

084192
stoichiometry: 1.0
species: 325954
type: SpeciesReference

092793
stoichiometry: 1.0
species: 326555
type: SpeciesReference

080248
stoichiometry: 1.0
species: 326259
type: SpeciesReference

327483
kinetic law: 087494
product: 087482
reactant: 087470
reactant: 087458
fast: false
reversible: true
name: v278 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

327597
kinetic law: 090288
product: 090276
reactant: 090264
reactant: 090252
fast: false
reversible: true
name: v335 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

083106
stoichiometry: 1.0
species: 326457
type: SpeciesReference

326999
kinetic law: 076211
product: 076199
reactant: 076187
reactant: 076175
fast: false
reversible: true
name: v27 EGF:ErbB1:ErbB3 + ATP -> EGF:ErbB1:ErbB3:ATP k122 kd122
type: Reaction

078779
stoichiometry: 1.0
species: 326237
type: SpeciesReference

326623
notes: (ERK#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_P)_i
type: Species

326028
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1:ATP
type: Species

327701
kinetic law: 092709
product: 092697
reactant: 092685
fast: false
reversible: true
name: v387 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23
type: Reaction

094671
stoichiometry: 1.0
species: 326577
type: SpeciesReference

099680
stoichiometry: 1.0
species: 326641
type: SpeciesReference

110808
stoichiometry: 1.0
species: 325950
type: SpeciesReference

106498
stoichiometry: 1.0
species: 326705
type: SpeciesReference

098525
stoichiometry: 1.0
species: 326625
type: SpeciesReference

082009
stoichiometry: 1.0
species: 326309
type: SpeciesReference

103844
stoichiometry: 1.0
species: 326749
type: SpeciesReference

088529
stoichiometry: 1.0
species: 326545
type: SpeciesReference

103952
stoichiometry: 1.0
species: 326751
type: SpeciesReference

094093
stoichiometry: 1.0
species: 326575
type: SpeciesReference

097561
stoichiometry: 1.0
species: 326581
type: SpeciesReference

107087
stoichiometry: 1.0
species: 326819
type: SpeciesReference

325970
has part: P00533
constant: false
initial concentration: NaN
notes: (EGF:ErbB1:ErbB2):Inh , plasma membrane
initial amount: 0.0
boundary condition: false
in compartment: 325898
type: Species
name: (EGF:ErbB1:ErbB2):Inh
has only substance units: true
has version: P01133

093851
stoichiometry: 1.0
species: 326575
type: SpeciesReference

111732
stoichiometry: 1.0
species: 325988
type: SpeciesReference

328525
kinetic law: 111456
product: 111444
reactant: 111432
reactant: 111420
fast: false
reversible: true
name: v805 EGF:ErbB1:ErbB1_h:Inh + ATP -> k122 kd122
type: Reaction

328311
kinetic law: 106328
product: 106316
reactant: 106304
reactant: 106292
fast: false
reversible: true
name: v697 PIP2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
type: Reaction

089860
stoichiometry: 1.0
species: 326547
type: SpeciesReference

327505
kinetic law: 088022
product: 088010
reactant: 087998
reactant: 087986
fast: false
reversible: true
name: v289 Ras:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326773
notes: ErbB1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1080000.0
in compartment: 325898
name: ErbB1
type: Species

103230
stoichiometry: 1.0
species: 326719
type: SpeciesReference

089913
stoichiometry: 1.0
species: 326549
type: SpeciesReference

328273
kinetic law: 105412
product: 105400
reactant: 105388
reactant: 105376
fast: false
reversible: true
name: v678 ErbB2 + ErbB3 -> (ErbB2:ErbB3) k103 kd103
type: Reaction

327481
kinetic law: 087446
product: 087434
reactant: 087422
reactant: 087410
fast: false
reversible: true
name: v277 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

326026
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1
type: Species

100581
stoichiometry: 1.0
species: 326641
type: SpeciesReference

329091
constant: true
value: 1.5E-6
name: k37
type: Parameter

085047
stoichiometry: 1.0
species: 326521
type: SpeciesReference

090542
stoichiometry: 1.0
species: 326217
type: SpeciesReference

327595
kinetic law: 090240
product: 090228
reactant: 090216
reactant: 090204
fast: false
reversible: true
name: v334 2(ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

089986
stoichiometry: 1.0
species: 326385
type: SpeciesReference

326621
notes: MEK#P#P:ERK , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP:ERK
type: Species

327703
kinetic law: 092745
product: 092733
reactant: 092721
fast: false
reversible: true
name: v388 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23
type: Reaction

100424
stoichiometry: 1.0
species: 326365
type: SpeciesReference

111528
stoichiometry: 1.0
species: 325980
type: SpeciesReference

325972
notes: ErbB4:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4:Inh
type: Species

093212
stoichiometry: 1.0
species: 326539
type: SpeciesReference

080716
stoichiometry: 1.0
species: 326355
type: SpeciesReference

105786
stoichiometry: 1.0
species: 326795
type: SpeciesReference

079044
stoichiometry: 1.0
species: 326259
type: SpeciesReference

328313
kinetic law: 106377
product: 106364
reactant: 106352
reactant: 106340
fast: false
reversible: true
name: v698 PIP2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
type: Reaction

327507
kinetic law: 088070
product: 088058
reactant: 088046
reactant: 088034
fast: false
reversible: true
name: v290 (Ras:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

326771
notes: ErbB2#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB2_P
type: Species

109351
stoichiometry: 1.0
species: 326867
type: SpeciesReference

112783
stoichiometry: 1.0
species: 326933
type: SpeciesReference

328527
kinetic law: 111504
product: 111492
reactant: 111480
reactant: 111468
fast: false
reversible: true
name: v806 2(EGF:ErbB1)#P + ATP -> k123 kd123
type: Reaction

083468
stoichiometry: 1.0
species: 326463
type: SpeciesReference

099030
stoichiometry: 1.0
species: 326631
type: SpeciesReference

077683
stoichiometry: 1.0
species: 326056
type: SpeciesReference

092467
stoichiometry: 1.0
species: 326441
type: SpeciesReference

108760
stoichiometry: 1.0
species: 326859
type: SpeciesReference

110207
stoichiometry: 1.0
species: 326889
type: SpeciesReference

328493
kinetic law: 110700
product: 110688
reactant: 110676
reactant: 110664
fast: false
reversible: true
name: v788 + HRG:ErbB4 -> k120 kd120
type: Reaction

076705
stoichiometry: 1.0
species: 326034
type: SpeciesReference

112771
stoichiometry: 1.0
species: 326921
type: SpeciesReference

106401
stoichiometry: 1.0
species: 326697
type: SpeciesReference

097417
stoichiometry: 1.0
species: 326581
type: SpeciesReference

098308
stoichiometry: 1.0
species: 326603
type: SpeciesReference

326995
kinetic law: 076115
product: 076103
reactant: 076091
reactant: 076079
fast: false
reversible: true
name: v25 2(EGF:ErbB1:ATP)) + ATP -> k122 kd122
type: Reaction

084830
stoichiometry: 1.0
species: 326088
type: SpeciesReference

326024
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:ATP
type: Species

326627
notes: ERK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ERK_PP
type: Species

093080
stoichiometry: 1.0
species: 326088
type: SpeciesReference

079516
stoichiometry: 1.0
species: 326056
type: SpeciesReference

325974
name: (EGF:ErbB1:ErbB3)_P:Inh
has version: P01133
notes: (EGF:ErbB1:ErbB3)#P:Inh , plasma membrane
boundary condition: false
constant: false
has only substance units: true
type: Species
initial concentration: NaN
in compartment: 325898
has part: P00533
initial amount: 0.0

077744
stoichiometry: 1.0
species: 326122
type: SpeciesReference

098416
stoichiometry: 1.0
species: 326617
type: SpeciesReference

329011
constant: true
value: 0.0
name: k14
type: Parameter

327509
kinetic law: 088118
product: 088106
reactant: 088094
reactant: 088082
fast: false
reversible: true
name: v291 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

328497
kinetic law: 110796
product: 110784
reactant: 110772
reactant: 110760
fast: false
reversible: true
name: v790 HRG:ErbB4 + ErbB1:ATP -> (HRG:ErbB4:ErbB1) k120b kd120
type: Reaction

101109
stoichiometry: 1.0
species: 326341
type: SpeciesReference

328315
kinetic law: 106425
product: 106413
reactant: 106401
reactant: 106389
fast: false
reversible: true
name: v699 PIP2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106
type: Reaction

105919
stoichiometry: 1.0
species: 326801
type: SpeciesReference

112442
stoichiometry: 1.0
species: 326044
type: SpeciesReference

328529
kinetic law: 111552
product: 111540
reactant: 111528
reactant: 111516
fast: false
reversible: true
name: v807 (ErbB1:ErbB2)#P + ATP -> EGF:ErbB1:ErbB2:ATP k123 kd123
type: Reaction

105859
stoichiometry: 1.0
species: 326054
type: SpeciesReference

107447
stoichiometry: 1.0
species: 326707
type: SpeciesReference

094045
stoichiometry: 1.0
species: 326575
type: SpeciesReference

328495
kinetic law: 110748
product: 110736
reactant: 110724
reactant: 110712
fast: false
reversible: true
name: v789 HRG:ErbB3 + ErbB1:ATP -> (HRG:ErbB3:ErbB1) k120b kd120
type: Reaction

329013
constant: true
value: 0.0
name: kd14
type: Parameter

326625
notes: MEK#P#P:ERK#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP:ERK_P
type: Species

079357
stoichiometry: 1.0
species: 326285
type: SpeciesReference

327599
kinetic law: 090336
product: 090324
reactant: 090312
reactant: 090300
fast: false
reversible: true
name: v336 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

082346
stoichiometry: 1.0
species: 326064
type: SpeciesReference

095525
stoichiometry: 1.0
species: 326523
type: SpeciesReference

326022
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1
type: Species

326997
kinetic law: 076163
product: 076151
reactant: 076139
reactant: 076127
fast: false
reversible: true
name: v26 EGF:ErbB1:ErbB2 + ATP -> EGF:ErbB1:ErbB2:ATP k122 kd122
type: Reaction

329375
constant: false
value: 0.1
name: kd120b
type: Parameter

089168
stoichiometry: 1.0
species: 326265
type: SpeciesReference

326134
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

079116
stoichiometry: 1.0
species: 326265
type: SpeciesReference

090760
stoichiometry: 1.0
species: 326084
type: SpeciesReference

087650
stoichiometry: 1.0
species: 326541
type: SpeciesReference

076271
stoichiometry: 1.0
species: 325998
type: SpeciesReference

086604
stoichiometry: 1.0
species: 326104
type: SpeciesReference

096764
stoichiometry: 1.0
species: 326577
type: SpeciesReference

327921
kinetic law: 097910
product: 097898
reactant: 097886
reactant: 097874
fast: false
reversible: true
name: v497 MEK#P#P + Raf#P -> MEK#P:Raf#P k47 kd47
type: Reaction

102676
stoichiometry: 1.0
species: 326677
type: SpeciesReference

077973
stoichiometry: 1.0
species: 326056
type: SpeciesReference

328385
kinetic law: 108110
product: 108098
reactant: 108086
reactant: 108074
fast: false
reversible: true
name: v734 (ERK#P#P)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
type: Reaction

091818
stoichiometry: 1.0
species: 326433
type: SpeciesReference

091000
stoichiometry: 1.0
species: 326387
type: SpeciesReference

326020
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1:ATP
type: Species

328419
kinetic law: 108930
product: 108918
reactant: 108906
reactant: 108893
fast: false
reversible: true
name: v751 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k112 kd112
type: Reaction

328063
kinetic law: 100772
product: 100760
reactant: 100748
fast: false
reversible: true
name: v572 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

076814
stoichiometry: 1.0
species: 325980
type: SpeciesReference

087145
stoichiometry: 1.0
species: 326221
type: SpeciesReference

328205
kinetic law: 103772
product: 103760
reactant: 103748
reactant: 103736
fast: false
reversible: true
name: v644 AKT#P#P + PIP3:PDK1 -> PIP3:AKT#P:PDK1 k72 kd72
type: Reaction

106510
stoichiometry: 1.0
species: 326803
type: SpeciesReference

326991
kinetic law: 076019
product: 076007
reactant: 075995
reactant: 075983
fast: false
reversible: true
name: v23 (EGF:ErbB1:ErbB4) + ATP -> (EGF:ErbB1:ErbB4):ATP k122 kd122
type: Reaction

100364
stoichiometry: 1.0
species: 326641
type: SpeciesReference

093368
stoichiometry: 1.0
species: 326213
type: SpeciesReference

080824
stoichiometry: 1.0
species: 326211
type: SpeciesReference

102122
stoichiometry: 1.0
species: 326657
type: SpeciesReference

086207
stoichiometry: 1.0
species: 326539
type: SpeciesReference

092576
stoichiometry: 1.0
species: 326447
type: SpeciesReference

326096
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2
type: Species

329373
constant: false
value: 5.92538E-11
name: k120b
type: Parameter

326132
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

100076
stoichiometry: 1.0
species: 326641
type: SpeciesReference

099392
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326841
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP
type: Species

090083
stoichiometry: 1.0
species: 326225
type: SpeciesReference

101941
stoichiometry: 1.0
species: 326050
type: SpeciesReference

328161
kinetic law: 102712
product: 102700
reactant: 102688
reactant: 102676
fast: false
reversible: true
name: v622 PI3K + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
type: Reaction

108568
stoichiometry: 1.0
species: 326855
type: SpeciesReference

099608
stoichiometry: 1.0
species: 326641
type: SpeciesReference

104616
stoichiometry: 1.0
species: 326651
type: SpeciesReference

101001
stoichiometry: 1.0
species: 326447
type: SpeciesReference

111324
stoichiometry: 1.0
species: 326425
type: SpeciesReference

086123
stoichiometry: 1.0
species: 326140
type: SpeciesReference

074964
stoichiometry: 1.0
species: 325918
type: SpeciesReference

328061
kinetic law: 100736
product: 100724
reactant: 100713
fast: false
reversible: true
name: v570 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
type: Reaction

084119
stoichiometry: 1.0
species: 326481
type: SpeciesReference

328207
kinetic law: 103820
product: 103808
reactant: 103796
reactant: 103784
fast: false
reversible: true
name: v645 AKT#P#P + Pase4 -> AKT#P#P:Pase4 k74 kd74
type: Reaction

327651
kinetic law: 091589
product: 091577
reactant: 091565
reactant: 091552
fast: false
reversible: true
name: v362 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

100004
stoichiometry: 1.0
species: 326641
type: SpeciesReference

109243
stoichiometry: 1.0
species: 326681
type: SpeciesReference

326993
kinetic law: 076067
product: 076055
reactant: 076043
reactant: 076031
fast: false
reversible: true
name: v24 2(EGF:ErbB1:ATP) + ATP -> 2(EGF:ErbB1):ATP k122 kd122
type: Reaction

089756
stoichiometry: 1.0
species: 326547
type: SpeciesReference

112184
stoichiometry: 1.0
species: 326024
type: SpeciesReference

328387
kinetic law: 108158
product: 108146
reactant: 108134
reactant: 108122
fast: false
reversible: true
name: v735 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
type: Reaction

109819
stoichiometry: 1.0
species: 326887
type: SpeciesReference

326094
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:cPP
type: Species

326130
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

092058
stoichiometry: 1.0
species: 326559
type: SpeciesReference

096884
stoichiometry: 1.0
species: 326104
type: SpeciesReference

101193
stoichiometry: 1.0
species: 326641
type: SpeciesReference

083528
stoichiometry: 1.0
species: 326493
type: SpeciesReference

082117
stoichiometry: 1.0
species: 326413
type: SpeciesReference

074818
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

326341
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

326843
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i
type: Species

095417
stoichiometry: 1.0
species: 326431
type: SpeciesReference

112223
stoichiometry: 1.0
species: 325980
type: SpeciesReference

084565
stoichiometry: 1.0
species: 326521
type: SpeciesReference

083817
stoichiometry: 1.0
species: 326493
type: SpeciesReference

326138
notes: (ErbB1:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:cPP
type: Species

327489
kinetic law: 087638
product: 087626
reactant: 087614
reactant: 087602
fast: false
reversible: true
name: v281 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

110916
stoichiometry: 1.0
species: 326907
type: SpeciesReference

329371
constant: false
value: 0.1
name: kd120
type: Parameter

326779
notes: ErbB3#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3_P
type: Species

112118
stoichiometry: 1.0
species: 325980
type: SpeciesReference

112831
stoichiometry: 1.0
species: 326935
type: SpeciesReference

094153
stoichiometry: 1.0
species: 326397
type: SpeciesReference

084770
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327593
kinetic law: 090192
product: 090180
reactant: 090167
reactant: 090155
fast: false
reversible: true
name: v333 2(ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

078995
stoichiometry: 1.0
species: 326255
type: SpeciesReference

328069
kinetic law: 100880
product: 100868
reactant: 100856
fast: false
reversible: true
name: v575 2(ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
type: Reaction

328163
kinetic law: 102760
product: 102748
reactant: 102736
reactant: 102724
fast: false
reversible: true
name: v623 PI3K + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
type: Reaction

105437
stoichiometry: 1.0
species: 325946
type: SpeciesReference

107219
stoichiometry: 1.0
species: 326010
type: SpeciesReference

107930
stoichiometry: 1.0
species: 326627
type: SpeciesReference

075846
stoichiometry: 1.0
species: 325976
type: SpeciesReference

328389
kinetic law: 108206
product: 108194
reactant: 108182
reactant: 108170
fast: false
reversible: true
name: v736 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
type: Reaction

328201
kinetic law: 103676
product: 103664
reactant: 103652
reactant: 103640
fast: false
reversible: true
name: v642 PDK1 + PIP3:AKT -> PIP3:AKT:PDK1 k70 kd70
type: Reaction

328415
kinetic law: 108832
product: 108820
reactant: 108808
reactant: 108796
fast: false
reversible: true
name: v749 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
type: Reaction

074769
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

078106
stoichiometry: 1.0
species: 326152
type: SpeciesReference

088492
stoichiometry: 1.0
species: 326391
type: SpeciesReference

079624
stoichiometry: 1.0
species: 326307
type: SpeciesReference

105581
stoichiometry: 1.0
species: 325968
type: SpeciesReference

081623
stoichiometry: 1.0
species: 326309
type: SpeciesReference

326092
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2
type: Species

101085
stoichiometry: 1.0
species: 326641
type: SpeciesReference

091228
stoichiometry: 1.0
species: 326541
type: SpeciesReference

090444
stoichiometry: 1.0
species: 326233
type: SpeciesReference

077261
stoichiometry: 1.0
species: 326082
type: SpeciesReference

108339
stoichiometry: 1.0
species: 326837
type: SpeciesReference

101217
stoichiometry: 1.0
species: 326325
type: SpeciesReference

105425
stoichiometry: 1.0
species: 325938
type: SpeciesReference

076043
stoichiometry: 1.0
species: 325980
type: SpeciesReference

085506
stoichiometry: 1.0
species: 326273
type: SpeciesReference

097778
stoichiometry: 1.0
species: 326595
type: SpeciesReference

100220
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327501
kinetic law: 087926
product: 087914
reactant: 087902
reactant: 087890
fast: false
reversible: true
name: v287 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

328981
constant: true
value: 0.80833
name: kd5
type: Parameter

326777
notes: EGF:ErbB1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: EGF:ErbB1_P
type: Species

326136
notes: (ErbB1:ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2
type: Species

099452
stoichiometry: 1.0
species: 326413
type: SpeciesReference

326343
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

327487
kinetic law: 087590
product: 087578
reactant: 087566
reactant: 087554
fast: false
reversible: true
name: v280 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

326845
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP
type: Species

328067
kinetic law: 100844
product: 100832
reactant: 100820
fast: false
reversible: true
name: v574 2(ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60
type: Reaction

327591
kinetic law: 090143
product: 090131
reactant: 090119
reactant: 090107
fast: false
reversible: true
name: v332 (Ras_activated:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

106882
stoichiometry: 1.0
species: 326683
type: SpeciesReference

092685
stoichiometry: 1.0
species: 326435
type: SpeciesReference

102013
stoichiometry: 1.0
species: 326653
type: SpeciesReference

079948
stoichiometry: 1.0
species: 326323
type: SpeciesReference

328165
kinetic law: 102809
product: 102797
reactant: 102785
reactant: 102773
fast: false
reversible: true
name: v624 PI3K + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
type: Reaction

328203
kinetic law: 103724
product: 103712
reactant: 103700
reactant: 103688
fast: false
reversible: true
name: v643 PIP3:PDK1 + AKT#P -> PIP3:AKT:PDK1 k71 kd71
type: Reaction

076055
stoichiometry: 1.0
species: 325988
type: SpeciesReference

328065
kinetic law: 100808
product: 100796
reactant: 100784
fast: false
reversible: true
name: v573 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

110580
stoichiometry: 1.0
species: 325938
type: SpeciesReference

328417
kinetic law: 108881
product: 108868
reactant: 108856
reactant: 108844
fast: false
reversible: true
name: v750 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
type: Reaction

106894
stoichiometry: 1.0
species: 326811
type: SpeciesReference

329159
constant: true
value: 0.0
name: kd60
type: Parameter

326090
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:cPP
type: Species

093961
stoichiometry: 1.0
species: 326100
type: SpeciesReference

103736
stoichiometry: 1.0
species: 326747
type: SpeciesReference

083673
stoichiometry: 1.0
species: 326493
type: SpeciesReference

088759
stoichiometry: 1.0
species: 326361
type: SpeciesReference

095045
stoichiometry: 1.0
species: 326507
type: SpeciesReference

085121
stoichiometry: 1.0
species: 326213
type: SpeciesReference

096102
stoichiometry: 1.0
species: 326523
type: SpeciesReference

106160
stoichiometry: 1.0
species: 326801
type: SpeciesReference

099308
stoichiometry: 1.0
species: 326417
type: SpeciesReference

092346
stoichiometry: 1.0
species: 326443
type: SpeciesReference

087506
stoichiometry: 1.0
species: 326541
type: SpeciesReference

329157
constant: true
value: 0.00266742
name: k60
type: Parameter

086063
stoichiometry: 1.0
species: 326539
type: SpeciesReference

075482
stoichiometry: 1.0
species: 325954
type: SpeciesReference

327645
kinetic law: 091444
product: 091432
reactant: 091420
reactant: 091408
fast: false
reversible: true
name: v359 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

328167
kinetic law: 102858
product: 102846
reactant: 102834
reactant: 102821
fast: false
reversible: true
name: v625 PI3K + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
type: Reaction

100820
stoichiometry: 1.0
species: 326349
type: SpeciesReference

328423
kinetic law: 109026
product: 109014
reactant: 109002
reactant: 108990
fast: false
reversible: true
name: v753 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
type: Reaction

076899
stoichiometry: 1.0
species: 326050
type: SpeciesReference

102990
stoichiometry: 1.0
species: 326709
type: SpeciesReference

097898
stoichiometry: 1.0
species: 326597
type: SpeciesReference

090616
stoichiometry: 1.0
species: 326351
type: SpeciesReference

327929
kinetic law: 098103
product: 098091
reactant: 098079
reactant: 098067
fast: false
reversible: true
name: v501 MEK#P + Pase2 -> MEK#P#P:Pase2 k49 kd49
type: Reaction

091456
stoichiometry: 1.0
species: 326325
type: SpeciesReference

082081
stoichiometry: 1.0
species: 326078
type: SpeciesReference

327371
kinetic law: 084794
product: 084782
reactant: 084770
reactant: 084758
fast: false
reversible: true
name: v222 (ErbB1:ErbB4)#P:GAP + Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24
type: Reaction

328971
constant: true
value: 6.73E-6
name: k4
type: Parameter

326847
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i
type: Species

326333
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

098079
stoichiometry: 1.0
species: 326603
type: SpeciesReference

077828
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327855
kinetic law: 096318
product: 096306
reactant: 096294
reactant: 096282
fast: false
reversible: true
name: v464 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

088820
stoichiometry: 1.0
species: 326545
type: SpeciesReference

091710
stoichiometry: 1.0
species: 326541
type: SpeciesReference

329223
constant: true
value: 3.5E-5
name: k22b
type: Parameter

081197
stoichiometry: 1.0
species: 326375
type: SpeciesReference

105641
stoichiometry: 1.0
species: 326785
type: SpeciesReference

082455
stoichiometry: 1.0
species: 326429
type: SpeciesReference

079564
stoichiometry: 1.0
species: 326056
type: SpeciesReference

085820
stoichiometry: 1.0
species: 326539
type: SpeciesReference

092130
stoichiometry: 1.0
species: 326551
type: SpeciesReference

100796
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327647
kinetic law: 091492
product: 091480
reactant: 091468
reactant: 091456
fast: false
reversible: true
name: v360 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

328425
kinetic law: 109074
product: 109062
reactant: 109050
reactant: 109038
fast: false
reversible: true
name: v754 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
type: Reaction

328169
kinetic law: 102906
product: 102894
reactant: 102882
reactant: 102870
fast: false
reversible: true
name: v626 PI3K + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
type: Reaction

111060
stoichiometry: 1.0
species: 326913
type: SpeciesReference

078562
stoichiometry: 1.0
species: 326219
type: SpeciesReference

094803
stoichiometry: 1.0
species: 326495
type: SpeciesReference

101736
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326491
notes: 2(ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P)
type: Species

095633
stoichiometry: 1.0
species: 326531
type: SpeciesReference

328973
constant: true
value: 1.66E-4
name: kd4
type: Parameter

326849
notes: ErbB3/4:ErbB2:Gab1#P## , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3/4:ErbB2:Gab1_P#
type: Species

329155
constant: true
value: 1.07E-5
name: k44
type: Parameter

102834
stoichiometry: 1.0
species: 326695
type: SpeciesReference

326335
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

075374
stoichiometry: 1.0
species: 325946
type: SpeciesReference

329221
constant: true
value: 0.0
name: kd60d
type: Parameter

326128
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

088674
stoichiometry: 1.0
species: 326209
type: SpeciesReference

327927
kinetic law: 098055
product: 098043
reactant: 098031
reactant: 098019
fast: false
reversible: true
name: v500 MEK#P#P + Pase2 -> MEK#P#P:Pase2 k48 kd48
type: Reaction

111252
stoichiometry: 1.0
species: 325934
type: SpeciesReference

096548
stoichiometry: 1.0
species: 326341
type: SpeciesReference

327857
kinetic law: 096368
product: 096355
reactant: 096343
reactant: 096330
fast: false
reversible: true
name: v465 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

081841
stoichiometry: 1.0
species: 326098
type: SpeciesReference

329379
constant: true
value: 0.001
name: k121
type: Parameter

098861
stoichiometry: 1.0
species: 326635
type: SpeciesReference

329225
constant: true
value: 0.1
name: kd22b
type: Parameter

106389
stoichiometry: 1.0
species: 326793
type: SpeciesReference

083961
stoichiometry: 1.0
species: 326477
type: SpeciesReference

329089
constant: true
value: 0.3
name: kd37
type: Parameter

326547
notes: Ras_activated:GTP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Ras_activated:GTP
type: Species

327375
kinetic law: 084890
product: 084878
reactant: 084866
reactant: 084854
fast: false
reversible: true
name: v224 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

327641
kinetic law: 091348
product: 091336
reactant: 091324
reactant: 091312
fast: false
reversible: true
name: v357 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

092274
stoichiometry: 1.0
species: 326551
type: SpeciesReference

102350
stoichiometry: 1.0
species: 326667
type: SpeciesReference

091601
stoichiometry: 1.0
species: 326285
type: SpeciesReference

328381
kinetic law: 108014
product: 108002
reactant: 107990
reactant: 107978
fast: false
reversible: true
name: v732 (ERK#P#P)_i + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
type: Reaction

327027
kinetic law: 076887
product: 076874
reactant: 076862
reactant: 076850
fast: false
reversible: true
name: v41 (HRG:ErbB3):ErbB2) + ATP -> (HRG:ErbB3):ErbB2):ATP k122 kd122
type: Reaction

327925
kinetic law: 098007
product: 097995
reactant: 097983
reactant: 097971
fast: false
reversible: true
name: v499 (MEK#P#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k48 kd48
type: Reaction

327859
kinetic law: 096416
product: 096404
reactant: 096392
reactant: 096380
fast: false
reversible: true
name: v466 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

326337
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

326279
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

329153
constant: true
value: 8.85125E-6
name: k52
type: Parameter

081101
stoichiometry: 1.0
species: 326371
type: SpeciesReference

079237
stoichiometry: 1.0
species: 326275
type: SpeciesReference

328975
constant: true
value: 0.0
name: k4b
type: Parameter

112613
stoichiometry: 1.0
species: 326909
type: SpeciesReference

108230
stoichiometry: 1.0
species: 326849
type: SpeciesReference

085687
stoichiometry: 1.0
species: 326273
type: SpeciesReference

080464
stoichiometry: 1.0
species: 326309
type: SpeciesReference

108820
stoichiometry: 1.0
species: 326845
type: SpeciesReference

089417
stoichiometry: 1.0
species: 326369
type: SpeciesReference

329377
constant: true
value: 0.001
name: Ks
type: Parameter

329227
constant: true
value: 0.1
name: kd34b
type: Parameter

109579
stoichiometry: 1.0
species: 326573
type: SpeciesReference

080104
stoichiometry: 1.0
species: 326271
type: SpeciesReference

106738
stoichiometry: 1.0
species: 326727
type: SpeciesReference

097345
stoichiometry: 1.0
species: 326577
type: SpeciesReference

095261
stoichiometry: 1.0
species: 326577
type: SpeciesReference

328421
kinetic law: 108978
product: 108966
reactant: 108954
reactant: 108942
fast: false
reversible: true
name: v752 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
type: Reaction

326549
notes: (Ras_activated:GTP)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Ras_activated:GTP)_i
type: Species

110399
stoichiometry: 1.0
species: 326897
type: SpeciesReference

085579
stoichiometry: 1.0
species: 326509
type: SpeciesReference

107159
stoichiometry: 1.0
species: 326805
type: SpeciesReference

103507
stoichiometry: 1.0
species: 326731
type: SpeciesReference

088964
stoichiometry: 1.0
species: 326253
type: SpeciesReference

327643
kinetic law: 091396
product: 091384
reactant: 091372
reactant: 091360
fast: false
reversible: true
name: v358 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

104120
stoichiometry: 1.0
species: 326755
type: SpeciesReference

327373
kinetic law: 084842
product: 084830
reactant: 084818
reactant: 084806
fast: false
reversible: true
name: v223 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

110676
stoichiometry: 1.0
species: 326905
type: SpeciesReference

084071
stoichiometry: 1.0
species: 326483
type: SpeciesReference

328383
kinetic law: 108062
product: 108050
reactant: 108038
reactant: 108026
fast: false
reversible: true
name: v733 ERK#P#P + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
type: Reaction

080188
stoichiometry: 1.0
species: 326333
type: SpeciesReference

326339
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

327029
kinetic law: 076935
product: 076923
reactant: 076911
reactant: 076899
fast: false
reversible: true
name: v42 (HRG:ErbB4):ErbB2) + ATP -> (HRG:ErbB4):ErbB2):ATP k122 kd122
type: Reaction

327923
kinetic law: 097959
product: 097946
reactant: 097934
reactant: 097922
fast: false
reversible: true
name: v498 (Raf#P)_i + (MEK#P#P)_i -> (MEK#P:Raf#P)_i k47 kd47
type: Reaction

328977
constant: true
value: 1.66E-4
name: kd4b
type: Parameter

327269
kinetic law: 082623
product: 082611
reactant: 082599
fast: false
reversible: true
name: v170 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k6 kd6
type: Reaction

326098
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:cPP
type: Species

076475
stoichiometry: 1.0
species: 325980
type: SpeciesReference

329151
constant: false
value: 56.7862
name: kd58
type: Parameter

326277
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

085603
stoichiometry: 1.0
species: 326281
type: SpeciesReference

326543
notes: Ras:GTP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Ras:GTP
type: Species

090976
stoichiometry: 1.0
species: 326399
type: SpeciesReference

102773
stoichiometry: 1.0
species: 326677
type: SpeciesReference

327379
kinetic law: 084986
product: 084974
reactant: 084962
reactant: 084950
fast: false
reversible: true
name: v226 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

326499
notes: (ErbB1:ErbB4)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP
type: Species

078226
stoichiometry: 1.0
species: 326191
type: SpeciesReference

329085
constant: true
value: 0.005
name: k36
type: Parameter

080032
stoichiometry: 1.0
species: 326309
type: SpeciesReference

106678
stoichiometry: 1.0
species: 326793
type: SpeciesReference

103014
stoichiometry: 1.0
species: 326707
type: SpeciesReference

329015
constant: true
value: 1.667E-8
name: k15
type: Parameter

327021
kinetic law: 076741
product: 076729
reactant: 076717
reactant: 076705
fast: false
reversible: true
name: v38 (HRG:ErbB4:ErbB1) + ATP -> (HRG:ErbB4:ErbB1):ATP k122 kd122
type: Reaction

327709
kinetic law: 092853
product: 092841
reactant: 092829
fast: false
reversible: true
name: v391 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23
type: Reaction

329229
constant: true
value: 7.5E-5
name: k34b
type: Parameter

326273
notes: (ErbB3:ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2
type: Species

093596
stoichiometry: 1.0
species: 326539
type: SpeciesReference

093657
stoichiometry: 1.0
species: 326565
type: SpeciesReference

104869
stoichiometry: 1.0
species: 325972
type: SpeciesReference

104965
stoichiometry: 1.0
species: 326667
type: SpeciesReference

327797
kinetic law: 094935
product: 094923
reactant: 094911
reactant: 094899
fast: false
reversible: true
name: v435 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

083069
stoichiometry: 1.0
species: 325972
type: SpeciesReference

327267
kinetic law: 082587
product: 082575
reactant: 082563
fast: false
reversible: true
name: v169 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k6 kd6
type: Reaction

326275
notes: (ErbB3:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:cPP
type: Species

110012
stoichiometry: 1.0
species: 326895
type: SpeciesReference

328979
notes: %internalization rate
constant: true
value: 0.0
name: k5
type: Parameter

327023
kinetic law: 076789
product: 076777
reactant: 076765
reactant: 076753
fast: false
reversible: true
name: v39 (HRG:ErbB4):ErbB2 + ATP -> (HRG:ErbB4):ErbB2:ATP k122 kd122
type: Reaction

091914
stoichiometry: 1.0
species: 326553
type: SpeciesReference

086976
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328305
kinetic law: 106184
product: 106172
reactant: 106160
reactant: 106148
fast: false
reversible: true
name: v694 (ErbB4:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

325976
notes: ErbB3:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3:Inh
type: Species

098753
stoichiometry: 1.0
species: 326631
type: SpeciesReference

112903
stoichiometry: 1.0
species: 326929
type: SpeciesReference

097053
stoichiometry: 1.0
species: 326577
type: SpeciesReference

087722
stoichiometry: 1.0
species: 326293
type: SpeciesReference

104326
stoichiometry: 1.0
species: 326463
type: SpeciesReference

075584
stoichiometry: 1.0
species: 325938
type: SpeciesReference

326545
notes: (Ras:GTP)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Ras:GTP)_i
type: Species

326629
notes: (ERK#P#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_PP)_i
type: Species

327377
kinetic law: 084938
product: 084926
reactant: 084914
reactant: 084902
fast: false
reversible: true
name: v225 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

079696
stoichiometry: 1.0
species: 326309
type: SpeciesReference

108074
stoichiometry: 1.0
species: 326629
type: SpeciesReference

079720
stoichiometry: 1.0
species: 326303
type: SpeciesReference

329087
constant: true
value: 0.0
name: kd36
type: Parameter

099248
stoichiometry: 1.0
species: 326641
type: SpeciesReference

328491
kinetic law: 110652
product: 110640
reactant: 110628
reactant: 110616
fast: false
reversible: true
name: v787 (HRG:ErbB3) + ErbB2 -> (HRG:ErbB3):ErbB2) k120 kd120
type: Reaction

103592
stoichiometry: 1.0
species: 326739
type: SpeciesReference

107654
stoichiometry: 1.0
species: 326687
type: SpeciesReference

329017
constant: true
value: 0.0
name: kd15
type: Parameter

094525
stoichiometry: 1.0
species: 326577
type: SpeciesReference

327263
kinetic law: 082515
product: 082503
reactant: 082491
fast: false
reversible: true
name: v167 2(EGF:ErbB1)#P:GAP:Shc -> 2(EGF:ErbB1)#P:GAP:Shc k6 kd6
type: Reaction

326271
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

103616
stoichiometry: 1.0
species: 326741
type: SpeciesReference

110784
stoichiometry: 1.0
species: 326034
type: SpeciesReference

101688
stoichiometry: 1.0
species: 326515
type: SpeciesReference

327799
kinetic law: 094985
product: 094973
reactant: 094960
reactant: 094948
fast: false
reversible: true
name: v436 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
type: Reaction

328307
kinetic law: 106232
product: 106220
reactant: 106208
reactant: 106196
fast: false
reversible: true
name: v695 PIP2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
type: Reaction

327265
kinetic law: 082551
product: 082539
reactant: 082527
fast: false
reversible: true
name: v168 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k6 kd6
type: Reaction

096258
stoichiometry: 1.0
species: 326357
type: SpeciesReference

078081
stoichiometry: 1.0
species: 326150
type: SpeciesReference

105134
stoichiometry: 1.0
species: 326777
type: SpeciesReference

327025
kinetic law: 076838
product: 076826
reactant: 076814
reactant: 076802
fast: false
reversible: true
name: v40 (HRG:ErbB3):ErbB2 + ATP -> (HRG:ErbB3):ErbB2:ATP k122 kd122
type: Reaction

325978
has only substance units: true
initial concentration: NaN
constant: false
initial amount: 0.0
notes: (EGF:ErbB1:ErbB3)#P:Inh , plasma membrane
type: Species
name: (EGF:ErbB1:ErbB3)_P:Inh
in compartment: 325898
has part: P00533
has version: P01133
boundary condition: false

095153
stoichiometry: 1.0
species: 326577
type: SpeciesReference

099536
stoichiometry: 1.0
species: 326641
type: SpeciesReference

077189
stoichiometry: 1.0
species: 326076
type: SpeciesReference

110098
stoichiometry: 1.0
species: 326861
type: SpeciesReference

327705
kinetic law: 092781
product: 092769
reactant: 092757
fast: false
reversible: true
name: v389 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

327649
kinetic law: 091540
product: 091528
reactant: 091516
reactant: 091504
fast: false
reversible: true
name: v361 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

077213
stoichiometry: 1.0
species: 326078
type: SpeciesReference

100641
stoichiometry: 1.0
species: 326487
type: SpeciesReference

076923
stoichiometry: 1.0
species: 326052
type: SpeciesReference

329081
constant: false
value: 0.0015
name: kd35
type: Parameter

112564
stoichiometry: 1.0
species: 326773
type: SpeciesReference

326495
notes: (ErbB1:ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP
type: Species

089302
stoichiometry: 1.0
species: 326547
type: SpeciesReference

077538
stoichiometry: 1.0
species: 326056
type: SpeciesReference

096392
stoichiometry: 1.0
species: 326523
type: SpeciesReference

106051
stoichiometry: 1.0
species: 326229
type: SpeciesReference

107375
stoichiometry: 1.0
species: 326817
type: SpeciesReference

327261
kinetic law: 082479
product: 082467
reactant: 082455
fast: false
reversible: true
name: v166 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP k6 kd6
type: Reaction

081488
stoichiometry: 1.0
species: 326387
type: SpeciesReference

329019
constant: true
value: 1.67E-5
name: k16
type: Parameter

328275
kinetic law: 105461
product: 105449
reactant: 105437
reactant: 105425
fast: false
reversible: true
name: v679 ErbB2 + ErbB4 -> ErbB2:ErbB4 k103 kd103
type: Reaction

328277
kinetic law: 105509
product: 105497
reactant: 105485
reactant: 105473
fast: false
reversible: true
name: v680 ErbB2#P + ErbB3#P -> (ErbB3:ErbB2)#P k103 kd103
type: Reaction

326699
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P
type: Species

328531
kinetic law: 111600
product: 111588
reactant: 111576
reactant: 111564
fast: false
reversible: true
name: v808 (ErbB1:ErbB2)#P + ATP -> (EGF:ErbB1:ErbB2):ATP k123 kd123
type: Reaction

328309
kinetic law: 106280
product: 106268
reactant: 106256
reactant: 106244
fast: false
reversible: true
name: v696 PIP2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
type: Reaction

327851
kinetic law: 096222
product: 096210
reactant: 096198
reactant: 096186
fast: false
reversible: true
name: v462 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

084613
stoichiometry: 1.0
species: 326521
type: SpeciesReference

326493
is version of: P20936
constant: false
is described by: http://identifiers.org/omim/139150
name: GAP
has only substance units: true
in compartment: 325908
initial amount: 534751.0
notes: GAP , cytoplasm
is version of: IPR001936
boundary condition: false
initial concentration: NaN
type: Species

083395
stoichiometry: 1.0
species: 326485
type: SpeciesReference

091794
stoichiometry: 1.0
species: 326551
type: SpeciesReference

091565
stoichiometry: 1.0
species: 326541
type: SpeciesReference

326018
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1
type: Species

110423
stoichiometry: 1.0
species: 326885
type: SpeciesReference

329083
constant: false
value: 7.5E-6
name: k35
type: Parameter

327707
kinetic law: 092817
product: 092805
reactant: 092793
fast: false
reversible: true
name: v390 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
type: Reaction

079455
stoichiometry: 1.0
species: 326293
type: SpeciesReference

075012
stoichiometry: 1.0
species: 325922
type: SpeciesReference

326497
notes: (ErbB1:ErbB3)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP
type: Species

326541
notes: Ras:GDP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 58095.2
in compartment: 325908
name: Ras:GDP
type: Species

080536
stoichiometry: 1.0
species: 326235
type: SpeciesReference

103375
stoichiometry: 1.0
species: 326725
type: SpeciesReference

081342
stoichiometry: 1.0
species: 326381
type: SpeciesReference

104472
stoichiometry: 1.0
species: 325960
type: SpeciesReference

108002
stoichiometry: 1.0
species: 326839
type: SpeciesReference

326697
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

077103
stoichiometry: 1.0
species: 326056
type: SpeciesReference

097802
stoichiometry: 1.0
species: 326593
type: SpeciesReference

328533
kinetic law: 111648
product: 111636
reactant: 111624
reactant: 111612
fast: false
reversible: true
name: v809 (ErbB1:ErbB3)#P + ATP -> (EGF:ErbB1:ErbB3):ATP k123 kd123
type: Reaction

328279
kinetic law: 105557
product: 105545
reactant: 105533
reactant: 105521
fast: false
reversible: true
name: v681 ErbB2#P + ErbB4#P -> (ErbB4:ErbB2)#P k103 kd103
type: Reaction

081089
stoichiometry: 1.0
species: 326309
type: SpeciesReference

082563
stoichiometry: 1.0
species: 326060
type: SpeciesReference

327853
kinetic law: 096270
product: 096258
reactant: 096246
reactant: 096234
fast: false
reversible: true
name: v463 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

085930
stoichiometry: 1.0
species: 326349
type: SpeciesReference

090107
stoichiometry: 1.0
species: 326549
type: SpeciesReference

093500
stoichiometry: 1.0
species: 326539
type: SpeciesReference

096186
stoichiometry: 1.0
species: 326481
type: SpeciesReference

108604
stoichiometry: 1.0
species: 326627
type: SpeciesReference

075727
stoichiometry: 1.0
species: 325914
type: SpeciesReference

083661
stoichiometry: 1.0
species: 326425
type: SpeciesReference

103748
stoichiometry: 1.0
species: 326745
type: SpeciesReference

088723
stoichiometry: 1.0
species: 326545
type: SpeciesReference

087602
stoichiometry: 1.0
species: 326541
type: SpeciesReference

082250
stoichiometry: 1.0
species: 326419
type: SpeciesReference

329147
constant: true
value: 0.0
name: k57
type: Parameter

077478
stoichiometry: 1.0
species: 326100
type: SpeciesReference

075049
stoichiometry: 1.0
species: 325924
type: SpeciesReference

106148
stoichiometry: 1.0
species: 326281
type: SpeciesReference

112492
stoichiometry: 1.0
species: 326048
type: SpeciesReference

328957
constant: false
value: 518.0
name: k1d
type: Parameter

108182
stoichiometry: 1.0
species: 326703
type: SpeciesReference

090844
stoichiometry: 1.0
species: 326541
type: SpeciesReference

326677
has only substance units: true
has part: P42336
notes: PI3K , cytoplasm
is version of: REACT 4240.1
boundary condition: false
initial amount: 3.55656E7
has part: P42338
constant: false
name: PI3K
initial concentration: NaN
has part: P27986
type: Species
has part: O00459
in compartment: 325908

326050
notes: ((HRG:ErbB4):ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ((HRG:ErbB4):ErbB2)
type: Species

103158
stoichiometry: 1.0
species: 326707
type: SpeciesReference

103892
stoichiometry: 1.0
species: 326749
type: SpeciesReference

092901
stoichiometry: 1.0
species: 326561
type: SpeciesReference

326789
notes: ErbB4:Inh:ErbB2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4:Inh:ErbB2
type: Species

080680
stoichiometry: 1.0
species: 326223
type: SpeciesReference

326355
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

099488
stoichiometry: 1.0
species: 326411
type: SpeciesReference

084998
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327155
kinetic law: 079972
product: 079960
reactant: 079948
reactant: 079936
fast: false
reversible: true
name: v109 cPP + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k5b kd5b
type: Reaction

327205
kinetic law: 081173
product: 081161
reactant: 081149
reactant: 081137
fast: false
reversible: true
name: v137 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

078033
stoichiometry: 1.0
species: 326146
type: SpeciesReference

327133
kinetic law: 079443
product: 079430
reactant: 079418
reactant: 079406
fast: false
reversible: true
name: v98 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
type: Reaction

326569
notes: (Raf:Ras:GTP)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Raf:Ras:GTP)_i
type: Species

327131
kinetic law: 079394
product: 079382
reactant: 079370
reactant: 079357
fast: false
reversible: true
name: v97 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
type: Reaction

092829
stoichiometry: 1.0
species: 326557
type: SpeciesReference

093512
stoichiometry: 1.0
species: 326339
type: SpeciesReference

329149
constant: false
value: 8.33E-7
name: k58
type: Parameter

097199
stoichiometry: 1.0
species: 326577
type: SpeciesReference

326709
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
type: Species

326679
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P#)
type: Species

328521
kinetic law: 111360
product: 111348
reactant: 111336
reactant: 111324
fast: false
reversible: true
name: v803 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k123 kd123
type: Reaction

110147
stoichiometry: 1.0
species: 326679
type: SpeciesReference

097838
stoichiometry: 1.0
species: 326571
type: SpeciesReference

328955
constant: false
value: 0.1
name: kd1d
type: Parameter

095898
stoichiometry: 1.0
species: 326505
type: SpeciesReference

105195
stoichiometry: 1.0
species: 326777
type: SpeciesReference

109615
stoichiometry: 1.0
species: 326747
type: SpeciesReference

098621
stoichiometry: 1.0
species: 326615
type: SpeciesReference

104845
stoichiometry: 1.0
species: 325946
type: SpeciesReference

104989
stoichiometry: 1.0
species: 326671
type: SpeciesReference

326052
notes: ((HRG:ErbB4):ErbB2):ATP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ((HRG:ErbB4):ErbB2):ATP
type: Species

084493
stoichiometry: 1.0
species: 326413
type: SpeciesReference

326567
notes: Raf:Ras:GTP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Raf:Ras:GTP
type: Species

076523
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326353
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

327157
kinetic law: 080020
product: 080008
reactant: 079996
reactant: 079984
fast: false
reversible: true
name: v110 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
type: Reaction

108460
stoichiometry: 1.0
species: 326629
type: SpeciesReference

090952
stoichiometry: 1.0
species: 326132
type: SpeciesReference

327629
kinetic law: 091060
product: 091048
reactant: 091036
reactant: 091024
fast: false
reversible: true
name: v351 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

327207
kinetic law: 081221
product: 081209
reactant: 081197
reactant: 081185
fast: false
reversible: true
name: v138 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

112807
stoichiometry: 1.0
species: 326921
type: SpeciesReference

084276
stoichiometry: 1.0
species: 326521
type: SpeciesReference

107520
stoichiometry: 1.0
species: 326795
type: SpeciesReference

327151
kinetic law: 079876
product: 079864
reactant: 079852
reactant: 079840
fast: false
reversible: true
name: v107 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
type: Reaction

092046
stoichiometry: 1.0
species: 326495
type: SpeciesReference

090216
stoichiometry: 1.0
species: 326549
type: SpeciesReference

327091
kinetic law: 078430
product: 078418
reactant: 078406
reactant: 078394
fast: false
reversible: true
name: v76 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k4b kd4
type: Reaction

096066
stoichiometry: 1.0
species: 326401
type: SpeciesReference

326673
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Sos_P)
type: Species

328399
kinetic law: 108448
product: 108436
reactant: 108424
reactant: 108412
fast: false
reversible: true
name: v741 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k111 kd111
type: Reaction

087986
stoichiometry: 1.0
species: 326543
type: SpeciesReference

080560
stoichiometry: 1.0
species: 326309
type: SpeciesReference

327731
kinetic law: 093344
product: 093332
reactant: 093320
reactant: 093308
fast: false
reversible: true
name: v402 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

326054
notes: 2(EGF:ErbB1)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2
type: Species

075157
stoichiometry: 1.0
species: 325930
type: SpeciesReference

328097
kinetic law: 101386
product: 101374
reactant: 101362
fast: false
reversible: true
name: v590 (ErbB3:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
type: Reaction

090228
stoichiometry: 1.0
species: 326343
type: SpeciesReference

076427
stoichiometry: 1.0
species: 325980
type: SpeciesReference

108664
stoichiometry: 1.0
species: 326857
type: SpeciesReference

096476
stoichiometry: 1.0
species: 326507
type: SpeciesReference

104363
stoichiometry: 1.0
species: 326755
type: SpeciesReference

090155
stoichiometry: 1.0
species: 326233
type: SpeciesReference

327209
kinetic law: 081269
product: 081257
reactant: 081245
reactant: 081233
fast: false
reversible: true
name: v139 cPP + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k5 kd5b
type: Reaction

110303
stoichiometry: 1.0
species: 326893
type: SpeciesReference

101953
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327627
kinetic law: 091012
product: 091000
reactant: 090988
reactant: 090976
fast: false
reversible: true
name: v350 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

326351
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

326565
is version of: P04049
in compartment: 325908
notes: Raf , cytoplasm
initial concentration: NaN
boundary condition: false
is described by: http://identifiers.org/omim/164760
constant: false
type: Species
has only substance units: true
initial amount: 71131.2
name: Raf

328019
kinetic law: 099980
product: 099968
reactant: 099956
fast: false
reversible: true
name: v547 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

327153
kinetic law: 079924
product: 079912
reactant: 079900
reactant: 079888
fast: false
reversible: true
name: v108 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
type: Reaction

086219
stoichiometry: 1.0
species: 326381
type: SpeciesReference

093620
stoichiometry: 1.0
species: 326325
type: SpeciesReference

100605
stoichiometry: 1.0
species: 326483
type: SpeciesReference

091674
stoichiometry: 1.0
species: 326313
type: SpeciesReference

087818
stoichiometry: 1.0
species: 326297
type: SpeciesReference

096680
stoichiometry: 1.0
species: 326525
type: SpeciesReference

097441
stoichiometry: 1.0
species: 326579
type: SpeciesReference

326675
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:(Sos_P)
type: Species

328397
kinetic law: 108400
product: 108388
reactant: 108376
reactant: 108364
fast: false
reversible: true
name: v740 (ERK#P#P)_i + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
type: Reaction

328959
constant: true
value: 7.44622E-6
name: k2
type: Parameter

075740
stoichiometry: 1.0
species: 325968
type: SpeciesReference

076802
stoichiometry: 1.0
species: 326042
type: SpeciesReference

094345
stoichiometry: 1.0
species: 326277
type: SpeciesReference

326056
notes: cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 4498.73
in compartment: 325898
name: cPP
type: Species

328099
kinetic law: 101422
product: 101410
reactant: 101398
fast: false
reversible: true
name: v591 (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60
type: Reaction

083287
stoichiometry: 1.0
species: 325918
type: SpeciesReference

075688
stoichiometry: 1.0
species: 325926
type: SpeciesReference

091806
stoichiometry: 1.0
species: 326429
type: SpeciesReference

091036
stoichiometry: 1.0
species: 326541
type: SpeciesReference

107642
stoichiometry: 1.0
species: 326627
type: SpeciesReference

092984
stoichiometry: 1.0
species: 326072
type: SpeciesReference

105883
stoichiometry: 1.0
species: 326026
type: SpeciesReference

327625
kinetic law: 090964
product: 090952
reactant: 090940
reactant: 090928
fast: false
reversible: true
name: v349 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

101362
stoichiometry: 1.0
species: 326327
type: SpeciesReference

079128
stoichiometry: 1.0
species: 326056
type: SpeciesReference

076283
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326563
notes: (ErbB1:ErbB4)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Shc
type: Species

327579
kinetic law: 089847
product: 089834
reactant: 089821
reactant: 089808
fast: false
reversible: true
name: v326 Ras_activated:GTP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

078394
stoichiometry: 1.0
species: 326205
type: SpeciesReference

328093
kinetic law: 101314
product: 101302
reactant: 101290
fast: false
reversible: true
name: v588 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
type: Reaction

082310
stoichiometry: 1.0
species: 326421
type: SpeciesReference

326058
notes: 2(EGF:ErbB1)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:cPP
type: Species

326703
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P
type: Species

112999
stoichiometry: 1.0
species: 326933
type: SpeciesReference

327425
kinetic law: 086099
product: 086087
reactant: 086075
reactant: 086063
fast: false
reversible: true
name: v249 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

326243
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

326457
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P)
type: Species

108242
stoichiometry: 1.0
species: 326841
type: SpeciesReference

078454
stoichiometry: 1.0
species: 326056
type: SpeciesReference

111396
stoichiometry: 1.0
species: 325990
type: SpeciesReference

101845
stoichiometry: 1.0
species: 326641
type: SpeciesReference

088300
stoichiometry: 1.0
species: 326112
type: SpeciesReference

327735
kinetic law: 093440
product: 093428
reactant: 093416
reactant: 093404
fast: false
reversible: true
name: v404 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

080608
stoichiometry: 1.0
species: 326309
type: SpeciesReference

329025
constant: true
value: 0.06
name: kd17
type: Parameter

327095
kinetic law: 078526
product: 078514
reactant: 078502
reactant: 078490
fast: false
reversible: true
name: v78 2(ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
type: Reaction

109843
stoichiometry: 1.0
species: 326885
type: SpeciesReference

076319
stoichiometry: 1.0
species: 326002
type: SpeciesReference

328880
value: 1.0
name: kd
type: LocalParameter

328017
kinetic law: 099944
product: 099932
reactant: 099920
fast: false
reversible: true
name: v546 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

107411
stoichiometry: 1.0
species: 326026
type: SpeciesReference

327623
kinetic law: 090916
product: 090904
reactant: 090892
reactant: 090880
fast: false
reversible: true
name: v348 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

092154
stoichiometry: 1.0
species: 326563
type: SpeciesReference

329023
constant: true
value: 1.67E-5
name: k17
type: Parameter

326781
notes: ErbB4#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4_P
type: Species

078442
stoichiometry: 1.0
species: 326209
type: SpeciesReference

328303
kinetic law: 106136
product: 106124
reactant: 106111
reactant: 106099
fast: false
reversible: true
name: v693 (ErbB3:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

108906
stoichiometry: 1.0
species: 326681
type: SpeciesReference

081257
stoichiometry: 1.0
species: 326146
type: SpeciesReference

329367
constant: false
value: 0.0
name: k119
type: Parameter

326455
notes: ErbB4:Inh , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB4:Inh
type: Species

104905
stoichiometry: 1.0
species: 326775
type: SpeciesReference

089404
stoichiometry: 1.0
species: 326363
type: SpeciesReference

326241
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

087578
stoichiometry: 1.0
species: 326315
type: SpeciesReference

326701
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

327423
kinetic law: 086051
product: 086039
reactant: 086027
reactant: 086014
fast: false
reversible: true
name: v248 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

328095
kinetic law: 101350
product: 101338
reactant: 101326
fast: false
reversible: true
name: v589 (ErbB4:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
type: Reaction

327733
kinetic law: 093392
product: 093380
reactant: 093368
reactant: 093356
fast: false
reversible: true
name: v403 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

076175
stoichiometry: 1.0
species: 325944
type: SpeciesReference

089495
stoichiometry: 1.0
species: 326549
type: SpeciesReference

101470
stoichiometry: 1.0
species: 326335
type: SpeciesReference

106413
stoichiometry: 1.0
species: 326711
type: SpeciesReference

327959
kinetic law: 098825
product: 098813
reactant: 098801
reactant: 098789
fast: false
reversible: true
name: v516 (ERK#P#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k56 kd56
type: Reaction

103808
stoichiometry: 1.0
species: 326751
type: SpeciesReference

075897
stoichiometry: 1.0
species: 325980
type: SpeciesReference

075958
stoichiometry: 1.0
species: 325984
type: SpeciesReference

327093
kinetic law: 078478
product: 078466
reactant: 078454
reactant: 078442
fast: false
reversible: true
name: v77 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k4b kd4
type: Reaction

099860
stoichiometry: 1.0
species: 326641
type: SpeciesReference

081574
stoichiometry: 1.0
species: 326309
type: SpeciesReference

110688
stoichiometry: 1.0
species: 326038
type: SpeciesReference

108772
stoichiometry: 1.0
species: 326823
type: SpeciesReference

328015
kinetic law: 099908
product: 099896
reactant: 099884
fast: false
reversible: true
name: v545 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
type: Reaction

113144
stoichiometry: 1.0
species: 326425
type: SpeciesReference

105109
stoichiometry: 1.0
species: 326675
type: SpeciesReference

099042
stoichiometry: 1.0
species: 326617
type: SpeciesReference

079019
stoichiometry: 1.0
species: 326257
type: SpeciesReference

088952
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327621
kinetic law: 090868
product: 090856
reactant: 090844
reactant: 090832
fast: false
reversible: true
name: v347 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

090736
stoichiometry: 1.0
species: 326076
type: SpeciesReference

327139
kinetic law: 079588
product: 079576
reactant: 079564
reactant: 079552
fast: false
reversible: true
name: v101 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

084818
stoichiometry: 1.0
species: 326527
type: SpeciesReference

095729
stoichiometry: 1.0
species: 326535
type: SpeciesReference

099932
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326783
notes: ErbB2:ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB2:ErbB2:Inh
type: Species

100689
stoichiometry: 1.0
species: 326641
type: SpeciesReference

329021
constant: true
value: 1.667E-7
name: k16b
type: Parameter

328301
kinetic law: 106087
product: 106075
reactant: 106063
reactant: 106051
fast: false
reversible: true
name: v692 2(ErbB2)#P:GAP:Grb2 + Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
type: Reaction

100713
stoichiometry: 1.0
species: 326357
type: SpeciesReference

109567
stoichiometry: 1.0
species: 326747
type: SpeciesReference

105774
stoichiometry: 1.0
species: 326793
type: SpeciesReference

075946
stoichiometry: 1.0
species: 325980
type: SpeciesReference

329365
constant: true
value: 0.0103115
name: kd119
type: Parameter

327739
kinetic law: 093536
product: 093524
reactant: 093512
reactant: 093500
fast: false
reversible: true
name: v406 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

327429
kinetic law: 086195
product: 086183
reactant: 086171
reactant: 086159
fast: false
reversible: true
name: v251 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

326118
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

088832
stoichiometry: 1.0
species: 326371
type: SpeciesReference

326247
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:cPP
type: Species

083179
stoichiometry: 1.0
species: 326465
type: SpeciesReference

075532
stoichiometry: 1.0
species: 325958
type: SpeciesReference

328953
constant: false
value: 1.0
name: kd1c
type: Parameter

326707
has only substance units: true
type: Species
name: PIP3
is: CHEBI:16618
in compartment: 325908
initial amount: 0.0
boundary condition: false
notes: PIP3 , cytoplasm
initial concentration: NaN
constant: false

328013
kinetic law: 099872
product: 099860
reactant: 099848
fast: false
reversible: true
name: v544 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
type: Reaction

095393
stoichiometry: 1.0
species: 326072
type: SpeciesReference

107750
stoichiometry: 1.0
species: 326691
type: SpeciesReference

103266
stoichiometry: 1.0
species: 326709
type: SpeciesReference

094755
stoichiometry: 1.0
species: 326505
type: SpeciesReference

328179
kinetic law: 103146
product: 103134
reactant: 103122
reactant: 103110
fast: false
reversible: true
name: v631 PIP3 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
type: Reaction

086075
stoichiometry: 1.0
species: 326136
type: SpeciesReference

327137
kinetic law: 079540
product: 079528
reactant: 079516
reactant: 079503
fast: false
reversible: true
name: v100 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

326785
notes: ErbB3:ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3:ErbB2:Inh
type: Species

328011
kinetic law: 099836
product: 099824
reactant: 099812
fast: false
reversible: true
name: v543 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
type: Reaction

327159
kinetic law: 080068
product: 080056
reactant: 080044
reactant: 080032
fast: false
reversible: true
name: v111 cPP + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k5b kd5b
type: Reaction

080344
stoichiometry: 1.0
species: 326251
type: SpeciesReference

329257
constant: true
value: 0.0471248
name: k60b
type: Parameter

093863
stoichiometry: 1.0
species: 326076
type: SpeciesReference

092419
stoichiometry: 1.0
species: 326551
type: SpeciesReference

089548
stoichiometry: 1.0
species: 326060
type: SpeciesReference

094081
stoichiometry: 1.0
species: 326495
type: SpeciesReference

100856
stoichiometry: 1.0
species: 326347
type: SpeciesReference

104761
stoichiometry: 1.0
species: 326775
type: SpeciesReference

327427
kinetic law: 086147
product: 086135
reactant: 086123
reactant: 086111
fast: false
reversible: true
name: v250 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

089613
stoichiometry: 1.0
species: 326547
type: SpeciesReference

327737
kinetic law: 093488
product: 093476
reactant: 093464
reactant: 093452
fast: false
reversible: true
name: v405 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

328091
kinetic law: 101278
product: 101266
reactant: 101253
fast: false
reversible: true
name: v587 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
type: Reaction

326459
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:(Shc_P)
type: Species

328951
constant: false
value: 800.0
name: k1c
type: Parameter

326705
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

076631
stoichiometry: 1.0
species: 326028
type: SpeciesReference

326116
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

326245
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

111288
stoichiometry: 1.0
species: 325980
type: SpeciesReference

098982
stoichiometry: 1.0
species: 326613
type: SpeciesReference

097211
stoichiometry: 1.0
species: 326449
type: SpeciesReference

080236
stoichiometry: 1.0
species: 326335
type: SpeciesReference

081720
stoichiometry: 1.0
species: 326309
type: SpeciesReference

085796
stoichiometry: 1.0
species: 326289
type: SpeciesReference

327097
kinetic law: 078574
product: 078562
reactant: 078550
reactant: 078538
fast: false
reversible: true
name: v79 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
type: Reaction

106292
stoichiometry: 1.0
species: 326793
type: SpeciesReference

100929
stoichiometry: 1.0
species: 326343
type: SpeciesReference

079273
stoichiometry: 1.0
species: 326056
type: SpeciesReference

088396
stoichiometry: 1.0
species: 326120
type: SpeciesReference

085446
stoichiometry: 1.0
species: 326459
type: SpeciesReference

326787
notes: ErbB4:ErbB2:Inh , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB4:ErbB2:Inh
type: Species

110255
stoichiometry: 1.0
species: 326891
type: SpeciesReference

327099
kinetic law: 078622
product: 078610
reactant: 078598
reactant: 078586
fast: false
reversible: true
name: v80 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

327135
kinetic law: 079491
product: 079479
reactant: 079467
reactant: 079455
fast: false
reversible: true
name: v99 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

110520
stoichiometry: 1.0
species: 325946
type: SpeciesReference

092250
stoichiometry: 1.0
species: 326487
type: SpeciesReference

094129
stoichiometry: 1.0
species: 326497
type: SpeciesReference

111660
stoichiometry: 1.0
species: 326471
type: SpeciesReference

095585
stoichiometry: 1.0
species: 326529
type: SpeciesReference

329369
notes: %dimerization
constant: false
value: 1.48131E-8
name: k120
type: Parameter

081161
stoichiometry: 1.0
species: 326154
type: SpeciesReference

091746
stoichiometry: 1.0
species: 326319
type: SpeciesReference

329259
notes: %low affinity Iressa
constant: true
value: 3.5E-8
name: KD_iressa_wt
type: Parameter

093404
stoichiometry: 1.0
species: 326539
type: SpeciesReference

091324
stoichiometry: 1.0
species: 326541
type: SpeciesReference

102098
stoichiometry: 1.0
species: 326629
type: SpeciesReference

088239
stoichiometry: 1.0
species: 326060
type: SpeciesReference

089339
stoichiometry: 1.0
species: 326209
type: SpeciesReference

327841
kinetic law: 095982
product: 095970
reactant: 095958
reactant: 095946
fast: false
reversible: true
name: v457 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

108990
stoichiometry: 1.0
species: 326541
type: SpeciesReference

111204
stoichiometry: 1.0
species: 326923
type: SpeciesReference

112053
stoichiometry: 1.0
species: 326695
type: SpeciesReference

087000
stoichiometry: 1.0
species: 326375
type: SpeciesReference

328243
kinetic law: 104688
product: 104676
reactant: 104664
reactant: 104652
fast: false
reversible: true
name: v663 RTK_Pase + (ErbB4:ErbB2) -> (ErbB2:ErbB4)#P:RTK_Pase k95 kd95
type: Reaction

328175
kinetic law: 103050
product: 103038
reactant: 103026
reactant: 103014
fast: false
reversible: true
name: v629 PIP3 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
type: Reaction

108038
stoichiometry: 1.0
species: 326699
type: SpeciesReference

328241
kinetic law: 104640
product: 104628
reactant: 104616
reactant: 104604
fast: false
reversible: true
name: v662 RTK_Pase + (ErbB3:ErbB2) -> (ErbB2:ErbB3)#P:RTK_Pase k95 kd95
type: Reaction

084782
stoichiometry: 1.0
species: 326377
type: SpeciesReference

101121
stoichiometry: 1.0
species: 326641
type: SpeciesReference

078851
stoichiometry: 1.0
species: 326243
type: SpeciesReference

327581
kinetic law: 089899
product: 089886
reactant: 089873
reactant: 089860
fast: false
reversible: true
name: v327 Ras_activated:GTP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

326921
notes: EGF:ErbB1_h:ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: EGF:ErbB1_h:ATP
type: Species

327369
kinetic law: 084746
product: 084734
reactant: 084722
reactant: 084710
fast: false
reversible: true
name: v221 (ErbB1:ErbB3)#P:GAP + Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
type: Reaction

327953
kinetic law: 098681
product: 098669
reactant: 098657
reactant: 098645
fast: false
reversible: true
name: v513 ERK#P#P + MEK#P#P -> ERK#P:MEK#P#P k55 kd55
type: Reaction

087794
stoichiometry: 1.0
species: 326543
type: SpeciesReference

095429
stoichiometry: 1.0
species: 326523
type: SpeciesReference

329251
constant: true
value: 4.16E-4
name: k62b
type: Parameter

110904
stoichiometry: 1.0
species: 326423
type: SpeciesReference

326126
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

326461
notes: (ErbB1:ErbB2)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P
type: Species

326239
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

082105
stoichiometry: 1.0
species: 326309
type: SpeciesReference

078514
stoichiometry: 1.0
species: 326215
type: SpeciesReference

086327
stoichiometry: 1.0
species: 326359
type: SpeciesReference

329255
constant: true
value: 5.2E-4
name: k60c
type: Parameter

089289
stoichiometry: 1.0
species: 326205
type: SpeciesReference

109771
stoichiometry: 1.0
species: 326883
type: SpeciesReference

105291
stoichiometry: 1.0
species: 326781
type: SpeciesReference

328177
kinetic law: 103098
product: 103086
reactant: 103074
reactant: 103062
fast: false
reversible: true
name: v630 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K + PIP3 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
type: Reaction

086688
stoichiometry: 1.0
species: 326541
type: SpeciesReference

112340
stoichiometry: 1.0
species: 326036
type: SpeciesReference

097995
stoichiometry: 1.0
species: 326605
type: SpeciesReference

080969
stoichiometry: 1.0
species: 326199
type: SpeciesReference

109134
stoichiometry: 1.0
species: 326541
type: SpeciesReference

106063
stoichiometry: 1.0
species: 326801
type: SpeciesReference

096282
stoichiometry: 1.0
species: 326507
type: SpeciesReference

080896
stoichiometry: 1.0
species: 326309
type: SpeciesReference

077502
stoichiometry: 1.0
species: 326102
type: SpeciesReference

104048
stoichiometry: 1.0
species: 326757
type: SpeciesReference

107074
stoichiometry: 1.0
species: 326679
type: SpeciesReference

326124
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

083215
stoichiometry: 1.0
species: 326469
type: SpeciesReference

326237
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

102736
stoichiometry: 1.0
species: 326687
type: SpeciesReference

329253
constant: true
value: 0.0
name: kd60b
type: Parameter

327951
kinetic law: 098633
product: 098621
reactant: 098609
reactant: 098597
fast: false
reversible: true
name: v512 MEK#P#P + ERK#P -> ERK:MEK#P#P k53 kd53
type: Reaction

077153
stoichiometry: 1.0
species: 326056
type: SpeciesReference

111432
stoichiometry: 1.0
species: 325980
type: SpeciesReference

077201
stoichiometry: 1.0
species: 326056
type: SpeciesReference

076959
stoichiometry: 1.0
species: 326056
type: SpeciesReference

093380
stoichiometry: 1.0
species: 326217
type: SpeciesReference

109050
stoichiometry: 1.0
species: 326685
type: SpeciesReference

106774
stoichiometry: 1.0
species: 326805
type: SpeciesReference

102158
stoichiometry: 1.0
species: 326076
type: SpeciesReference

329401
constant: true
value: 1.0
name: KD
type: Parameter

080812
stoichiometry: 1.0
species: 326359
type: SpeciesReference

095165
stoichiometry: 1.0
species: 326289
type: SpeciesReference

328451
kinetic law: 109699
product: 109687
reactant: 109675
reactant: 109663
fast: false
reversible: true
name: v767 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser k115 kd115
type: Reaction

099716
stoichiometry: 1.0
species: 326641
type: SpeciesReference

328247
kinetic law: 104785
product: 104773
reactant: 104761
reactant: 104749
fast: false
reversible: true
name: v665 ErbB1 + Inh -> ErbB1:Inh k97 kd97
type: Reaction

087133
stoichiometry: 1.0
species: 326217
type: SpeciesReference

099500
stoichiometry: 1.0
species: 326641
type: SpeciesReference

100352
stoichiometry: 1.0
species: 326369
type: SpeciesReference

103459
stoichiometry: 1.0
species: 326727
type: SpeciesReference

077587
stoichiometry: 1.0
species: 326056
type: SpeciesReference

103604
stoichiometry: 1.0
species: 326737
type: SpeciesReference

088614
stoichiometry: 1.0
species: 326543
type: SpeciesReference

328171
kinetic law: 102954
product: 102942
reactant: 102930
reactant: 102918
fast: false
reversible: true
name: v627 PI3K + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
type: Reaction

329029
constant: true
value: 1.3
name: kd18
type: Parameter

328453
kinetic law: 109747
product: 109735
reactant: 109723
reactant: 109711
fast: false
reversible: true
name: v768 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser_i k115 kd115
type: Reaction

090517
stoichiometry: 1.0
species: 326343
type: SpeciesReference

327957
kinetic law: 098777
product: 098765
reactant: 098753
reactant: 098741
fast: false
reversible: true
name: v515 ERK#P#P + Pase3 -> ERK#P#P:Pase3 k56 kd56
type: Reaction

079756
stoichiometry: 1.0
species: 326315
type: SpeciesReference

329363
constant: true
value: 0.03
name: kd118
type: Parameter

326465
notes: (ErbB1:ErbB3)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P
type: Species

326899
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:_PP:Pase9t
type: Species

096957
stoichiometry: 1.0
species: 326577
type: SpeciesReference

326122
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

327365
kinetic law: 084650
product: 084638
reactant: 084626
reactant: 084613
fast: false
reversible: true
name: v219 Grb2 + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24
type: Reaction

110049
stoichiometry: 1.0
species: 326857
type: SpeciesReference

326925
notes: (EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive
type: Species

099596
stoichiometry: 1.0
species: 325954
type: SpeciesReference

327433
kinetic law: 086291
product: 086279
reactant: 086267
reactant: 086255
fast: false
reversible: true
name: v253 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

328519
kinetic law: 111312
product: 111300
reactant: 111288
reactant: 111276
fast: false
reversible: true
name: v802 (EGF:ErbB1:ErbB1):Inh + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k122 kd122
type: Reaction

107906
stoichiometry: 1.0
species: 326835
type: SpeciesReference

098765
stoichiometry: 1.0
species: 326633
type: SpeciesReference

098139
stoichiometry: 1.0
species: 326609
type: SpeciesReference

083540
stoichiometry: 1.0
species: 326497
type: SpeciesReference

080008
stoichiometry: 1.0
species: 326279
type: SpeciesReference

083033
stoichiometry: 1.0
species: 325968
type: SpeciesReference

326819
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):Shp2
type: Species

112915
stoichiometry: 1.0
species: 325980
type: SpeciesReference

091528
stoichiometry: 1.0
species: 326269
type: SpeciesReference

086940
stoichiometry: 1.0
species: 326209
type: SpeciesReference

095910
stoichiometry: 1.0
species: 326525
type: SpeciesReference

105545
stoichiometry: 1.0
species: 325922
type: SpeciesReference

328245
kinetic law: 104737
product: 104725
reactant: 104712
reactant: 104700
fast: false
reversible: true
name: v664 ErbB2#P + ErbB2#P -> 2(ErbB2)#P k96 kd96
type: Reaction

326791
notes: Shp , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 2213.59
in compartment: 325908
name: Shp
type: Species

089060
stoichiometry: 1.0
species: 326253
type: SpeciesReference

083865
stoichiometry: 1.0
species: 325918
type: SpeciesReference

087710
stoichiometry: 1.0
species: 326285
type: SpeciesReference

098813
stoichiometry: 1.0
species: 326635
type: SpeciesReference

074878
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

094273
stoichiometry: 1.0
species: 326483
type: SpeciesReference

104313
stoichiometry: 1.0
species: 326755
type: SpeciesReference

329027
constant: true
value: 2.5E-5
name: k18
type: Parameter

328173
kinetic law: 103002
product: 102990
reactant: 102978
reactant: 102966
fast: false
reversible: true
name: v628 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68b
type: Reaction

327955
kinetic law: 098729
product: 098717
reactant: 098705
reactant: 098693
fast: false
reversible: true
name: v514 (ERK#P#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK#P k55 kd55
type: Reaction

094441
stoichiometry: 1.0
species: 326253
type: SpeciesReference

099380
stoichiometry: 1.0
species: 326435
type: SpeciesReference

326463
notes: (ErbB1:ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P
type: Species

081005
stoichiometry: 1.0
species: 326367
type: SpeciesReference

085639
stoichiometry: 1.0
species: 326521
type: SpeciesReference

329361
constant: true
value: 0.0
name: k118
type: Parameter

327431
kinetic law: 086243
product: 086231
reactant: 086219
reactant: 086207
fast: false
reversible: true
name: v252 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

326120
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

327367
kinetic law: 084698
product: 084686
reactant: 084674
reactant: 084662
fast: false
reversible: true
name: v220 (ErbB1:ErbB2)#P:GAP + Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
type: Reaction

326923
notes: ErbB1_h:ATP , endosomes
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325900
name: ErbB1_h:ATP
type: Species

100461
stoichiometry: 1.0
species: 326363
type: SpeciesReference

326817
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2
type: Species

326573
notes: Raf#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Raf_P
type: Species

327589
kinetic law: 090095
product: 090083
reactant: 090071
reactant: 090059
fast: false
reversible: true
name: v331 Ras_activated:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

105037
stoichiometry: 1.0
species: 326671
type: SpeciesReference

327849
kinetic law: 096174
product: 096162
reactant: 096150
reactant: 096138
fast: false
reversible: true
name: v461 2(ErbB2)#P:GAP + (Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

106352
stoichiometry: 1.0
species: 326685
type: SpeciesReference

089962
stoichiometry: 1.0
species: 326549
type: SpeciesReference

325906
is: GO:0010008
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 2.0
name: endosomal membrane
type: Compartment

083769
stoichiometry: 1.0
species: 326493
type: SpeciesReference

328395
kinetic law: 108352
product: 108339
reactant: 108327
reactant: 108315
fast: false
reversible: true
name: v739 ERK#P#P + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
type: Reaction

077695
stoichiometry: 1.0
species: 326118
type: SpeciesReference

327361
kinetic law: 084553
product: 084541
reactant: 084529
reactant: 084517
fast: false
reversible: true
name: v217 Grb2 + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
type: Reaction

095093
stoichiometry: 1.0
species: 326511
type: SpeciesReference

328515
kinetic law: 111216
product: 111204
reactant: 111192
fast: false
reversible: true
name: v799 ErbB1_h:ATP + -> ErbB1_h:ATP k6 kd6
type: Reaction

084926
stoichiometry: 1.0
species: 326096
type: SpeciesReference

100569
stoichiometry: 1.0
species: 326643
type: SpeciesReference

326895
notes: ErbB3/4:ErbB2:Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB3/4:ErbB2:Gab1_P#:Pase9t
type: Species

326681
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

328457
kinetic law: 109831
product: 109819
reactant: 109807
reactant: 109795
fast: false
reversible: true
name: v770 Pase9t + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1):Gab1#P##:Pase9t k117 kd117
type: Reaction

106702
stoichiometry: 1.0
species: 326727
type: SpeciesReference

326929
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)
type: Species

326571
notes: (Raf#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Raf_P)_i
type: Species

327587
kinetic law: 090047
product: 090035
reactant: 090022
reactant: 090010
fast: false
reversible: true
name: v330 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

327211
kinetic law: 081318
product: 081305
reactant: 081293
reactant: 081281
fast: false
reversible: true
name: v140 cPP + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k5 kd5b
type: Reaction

329141
constant: false
value: 5.0
name: kd56
type: Parameter

326815
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2
type: Species

083974
stoichiometry: 1.0
species: 326511
type: SpeciesReference

327847
kinetic law: 096126
product: 096114
reactant: 096102
reactant: 096090
fast: false
reversible: true
name: v460 2(ErbB2)#P:GAP + (Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

112275
stoichiometry: 1.0
species: 325980
type: SpeciesReference

093164
stoichiometry: 1.0
species: 326539
type: SpeciesReference

326349
notes: 2(ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2
type: Species

328249
kinetic law: 104833
product: 104821
reactant: 104809
reactant: 104797
fast: false
reversible: true
name: v666 ErbB2 + Inh -> ErbB2:Inh k98 kd98
type: Reaction

328393
kinetic law: 108303
product: 108290
reactant: 108278
reactant: 108266
fast: false
reversible: true
name: v738 (ERK#P#P)_i + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
type: Reaction

105207
stoichiometry: 1.0
species: 326461
type: SpeciesReference

109916
stoichiometry: 1.0
species: 326891
type: SpeciesReference

089769
stoichiometry: 1.0
species: 326100
type: SpeciesReference

325904
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: medium
type: Compartment

083431
stoichiometry: 1.0
species: 326489
type: SpeciesReference

107303
stoichiometry: 1.0
species: 326805
type: SpeciesReference

104423
stoichiometry: 1.0
species: 325956
type: SpeciesReference

102362
stoichiometry: 1.0
species: 326655
type: SpeciesReference

079406
stoichiometry: 1.0
species: 326289
type: SpeciesReference

326927
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive
type: Species

327363
kinetic law: 084601
product: 084589
reactant: 084577
reactant: 084565
fast: false
reversible: true
name: v218 Grb2 + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
type: Reaction

328517
kinetic law: 111264
product: 111252
reactant: 111240
reactant: 111228
fast: false
reversible: true
name: v801 ErbB1_h:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
type: Reaction

098404
stoichiometry: 1.0
species: 326599
type: SpeciesReference

326683
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P
type: Species

326897
notes: ErbB1:ErbB:Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ErbB1:ErbB:Gab1_P#:Pase9t
type: Species

328455
kinetic law: 109783
product: 109771
reactant: 109759
fast: false
reversible: true
name: v769 Pase3 + -> MKP_deg k116 kd116
type: Reaction

111876
stoichiometry: 1.0
species: 326000
type: SpeciesReference

087241
stoichiometry: 1.0
species: 326237
type: SpeciesReference

095802
stoichiometry: 1.0
species: 326501
type: SpeciesReference

094875
stoichiometry: 1.0
species: 326361
type: SpeciesReference

081696
stoichiometry: 1.0
species: 326110
type: SpeciesReference

110832
stoichiometry: 1.0
species: 326050
type: SpeciesReference

090592
stoichiometry: 1.0
species: 326355
type: SpeciesReference

107978
stoichiometry: 1.0
species: 326629
type: SpeciesReference

096536
stoichiometry: 1.0
species: 326525
type: SpeciesReference

088046
stoichiometry: 1.0
species: 326355
type: SpeciesReference

327845
kinetic law: 096078
product: 096066
reactant: 096054
reactant: 096042
fast: false
reversible: true
name: v459 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

326813
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:Shp2
type: Species

327213
kinetic law: 081366
product: 081354
reactant: 081342
reactant: 081330
fast: false
reversible: true
name: v141 cPP + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k5 kd5b
type: Reaction

327585
kinetic law: 089998
product: 089986
reactant: 089974
reactant: 089962
fast: false
reversible: true
name: v329 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

084337
stoichiometry: 1.0
species: 326523
type: SpeciesReference

102846
stoichiometry: 1.0
species: 326697
type: SpeciesReference

326347
notes: 2(ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2:Sos
type: Species

329143
constant: false
value: 3.97392E-4
name: k56
type: Parameter

075386
stoichiometry: 1.0
species: 325914
type: SpeciesReference

097101
stoichiometry: 1.0
species: 326577
type: SpeciesReference

078743
stoichiometry: 1.0
species: 326056
type: SpeciesReference

325902
is: GO:0005764
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: lysosomes
type: Compartment

328391
kinetic law: 108254
product: 108242
reactant: 108230
reactant: 108218
fast: false
reversible: true
name: v737 ERK#P#P + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
type: Reaction

102506
stoichiometry: 1.0
species: 326657
type: SpeciesReference

326891
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:Pase9t
type: Species

090372
stoichiometry: 1.0
species: 326301
type: SpeciesReference

091890
stoichiometry: 1.0
species: 326551
type: SpeciesReference

328511
kinetic law: 111132
product: 111120
reactant: 111108
reactant: 111096
fast: false
reversible: true
name: v797 EGF:ErbB1_h:Inh + EGF:ErbB1_h:Inh -> 2(EGF:ErbB1_h:Inh) k2 kd2
type: Reaction

082467
stoichiometry: 1.0
species: 326431
type: SpeciesReference

084349
stoichiometry: 1.0
species: 326525
type: SpeciesReference

079552
stoichiometry: 1.0
species: 326301
type: SpeciesReference

104532
stoichiometry: 1.0
species: 326761
type: SpeciesReference

093272
stoichiometry: 1.0
species: 326403
type: SpeciesReference

083323
stoichiometry: 1.0
species: 325922
type: SpeciesReference

112662
stoichiometry: 1.0
species: 325914
type: SpeciesReference

326345
notes: 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

327583
kinetic law: 089950
product: 089938
reactant: 089925
reactant: 089913
fast: false
reversible: true
name: v328 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

327843
kinetic law: 096030
product: 096018
reactant: 096006
reactant: 095994
fast: false
reversible: true
name: v458 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

326811
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:Shp2
type: Species

111540
stoichiometry: 1.0
species: 325992
type: SpeciesReference

327215
kinetic law: 081415
product: 081403
reactant: 081391
reactant: 081378
fast: false
reversible: true
name: v142 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

087097
stoichiometry: 1.0
species: 326371
type: SpeciesReference

103303
stoichiometry: 1.0
species: 326707
type: SpeciesReference

084674
stoichiometry: 1.0
species: 326521
type: SpeciesReference

093308
stoichiometry: 1.0
species: 326539
type: SpeciesReference

091468
stoichiometry: 1.0
species: 326541
type: SpeciesReference

102446
stoichiometry: 1.0
species: 326671
type: SpeciesReference

325900
is: GO:0005768
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: endosomes
type: Compartment

328459
kinetic law: 109879
product: 109867
reactant: 109855
reactant: 109843
fast: false
reversible: true
name: v771 Pase9t + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)2:Gab1#P##:Pase9t k117 kd117
type: Reaction

328513
kinetic law: 111180
product: 111168
reactant: 111156
reactant: 111144
fast: false
reversible: true
name: v798 EGF + ErbB1_h:ATP -> EGF:ErbB1_h:ATP k1 kd1
type: Reaction

109495
stoichiometry: 1.0
species: 326873
type: SpeciesReference

326893
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:Pase9t
type: Species

091192
stoichiometry: 1.0
species: 326193
type: SpeciesReference

329145
constant: true
value: 0.0076
name: kd57
type: Parameter

107183
stoichiometry: 1.0
species: 326809
type: SpeciesReference

098332
stoichiometry: 1.0
species: 326609
type: SpeciesReference

085157
stoichiometry: 1.0
species: 326491
type: SpeciesReference

111768
stoichiometry: 1.0
species: 325980
type: SpeciesReference

082900
stoichiometry: 1.0
species: 325958
type: SpeciesReference

094429
stoichiometry: 1.0
species: 326575
type: SpeciesReference

329137
constant: true
value: 70.1662
name: kd55
type: Parameter

102591
stoichiometry: 1.0
species: 326671
type: SpeciesReference

108315
stoichiometry: 1.0
species: 326627
type: SpeciesReference

093524
stoichiometry: 1.0
species: 326337
type: SpeciesReference

090420
stoichiometry: 1.0
species: 326313
type: SpeciesReference

097826
stoichiometry: 1.0
species: 326585
type: SpeciesReference

110159
stoichiometry: 1.0
species: 326887
type: SpeciesReference

327419
kinetic law: 085954
product: 085942
reactant: 085930
reactant: 085918
fast: false
reversible: true
name: v246 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

328439
kinetic law: 109411
product: 109399
reactant: 109387
reactant: 109375
fast: false
reversible: true
name: v761 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
type: Reaction

328943
constant: true
units: item
value: 905000.0
name: total AKT
type: Parameter

106208
stoichiometry: 1.0
species: 326681
type: SpeciesReference

108194
stoichiometry: 1.0
species: 326847
type: SpeciesReference

079600
stoichiometry: 1.0
species: 326305
type: SpeciesReference

078971
stoichiometry: 1.0
species: 326253
type: SpeciesReference

084541
stoichiometry: 1.0
species: 326136
type: SpeciesReference

076535
stoichiometry: 1.0
species: 326020
type: SpeciesReference

326040
notes: (HRG:ErbB4):ErbB2:ATP , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (HRG:ErbB4):ErbB2:ATP
type: Species

326609
notes: MEK#P:Pase2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_P:Pase2
type: Species

109627
stoichiometry: 1.0
species: 326571
type: SpeciesReference

326579
initial amount: 50000.0
type: Species
initial concentration: NaN
has only substance units: true
constant: false
name: Pase1
is version of: P28562
notes: Pase1 , cytoplasm
boundary condition: false
in compartment: 325908

327617
kinetic law: 090772
product: 090760
reactant: 090748
reactant: 090736
fast: false
reversible: true
name: v345 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

327143
kinetic law: 079684
product: 079672
reactant: 079660
reactant: 079648
fast: false
reversible: true
name: v103 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
type: Reaction

092371
stoichiometry: 1.0
species: 326551
type: SpeciesReference

091986
stoichiometry: 1.0
species: 326551
type: SpeciesReference

327169
kinetic law: 080308
product: 080296
reactant: 080284
reactant: 080272
fast: false
reversible: true
name: v116 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
type: Reaction

326365
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

108472
stoichiometry: 1.0
species: 326853
type: SpeciesReference

075036
stoichiometry: 1.0
species: 325910
type: SpeciesReference

079479
stoichiometry: 1.0
species: 326295
type: SpeciesReference

082262
stoichiometry: 1.0
species: 326309
type: SpeciesReference

098019
stoichiometry: 1.0
species: 326599
type: SpeciesReference

329135
constant: true
value: 0.0
name: k53
type: Parameter

088735
stoichiometry: 1.0
species: 326375
type: SpeciesReference

108170
stoichiometry: 1.0
species: 326629
type: SpeciesReference

328945
constant: false
value: 0.0
name: total AKT_PP
type: Parameter

090856
stoichiometry: 1.0
species: 326124
type: SpeciesReference

326689
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

077091
stoichiometry: 1.0
species: 326068
type: SpeciesReference

111048
stoichiometry: 1.0
species: 325914
type: SpeciesReference

094537
stoichiometry: 1.0
species: 326575
type: SpeciesReference

078021
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327145
kinetic law: 079732
product: 079720
reactant: 079708
reactant: 079696
fast: false
reversible: true
name: v104 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
type: Reaction

327619
kinetic law: 090820
product: 090808
reactant: 090796
reactant: 090784
fast: false
reversible: true
name: v346 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

326367
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

327167
kinetic law: 080260
product: 080248
reactant: 080236
reactant: 080224
fast: false
reversible: true
name: v115 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b
type: Reaction

326821
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):ERK_PP
type: Species

091662
stoichiometry: 1.0
species: 326541
type: SpeciesReference

089834
stoichiometry: 1.0
species: 326128
type: SpeciesReference

100617
stoichiometry: 1.0
species: 326641
type: SpeciesReference

092973
stoichiometry: 1.0
species: 326539
type: SpeciesReference

109339
stoichiometry: 1.0
species: 326693
type: SpeciesReference

328007
kinetic law: 099764
product: 099752
reactant: 099740
fast: false
reversible: true
name: v541 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
type: Reaction

087806
stoichiometry: 1.0
species: 326289
type: SpeciesReference

326361
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos
type: Species

101506
stoichiometry: 1.0
species: 326333
type: SpeciesReference

328087
kinetic law: 101205
product: 101193
reactant: 101181
fast: false
reversible: true
name: v585 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60
type: Reaction

326044
notes: (HRG:ErbB3):ErbB2:ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB3):ErbB2:ATP
type: Species

077405
stoichiometry: 1.0
species: 326094
type: SpeciesReference

075675
stoichiometry: 1.0
species: 325946
type: SpeciesReference

326687
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P
type: Species

328947
constant: false
units: metaid_0000007
value: 0.0
name: model_time
type: Parameter

091698
stoichiometry: 1.0
species: 326289
type: SpeciesReference

105871
stoichiometry: 1.0
species: 326801
type: SpeciesReference

081476
stoichiometry: 1.0
species: 326309
type: SpeciesReference

093911
stoichiometry: 1.0
species: 326411
type: SpeciesReference

328089
kinetic law: 101241
product: 101229
reactant: 101217
fast: false
reversible: true
name: v586 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
type: Reaction

091024
stoichiometry: 1.0
species: 326397
type: SpeciesReference

087674
stoichiometry: 1.0
species: 326317
type: SpeciesReference

326575
notes: (Shc#P):Grb2:Sos , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Shc_P):Grb2:Sos
type: Species

326605
notes: (MEK#P#P:Pase2)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_PP:Pase2)_i
type: Species

089144
stoichiometry: 1.0
species: 326547
type: SpeciesReference

327567
kinetic law: 089535
product: 089522
reactant: 089508
reactant: 089495
fast: false
reversible: true
name: v320 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

076295
stoichiometry: 1.0
species: 326000
type: SpeciesReference

327165
kinetic law: 080212
product: 080200
reactant: 080188
reactant: 080176
fast: false
reversible: true
name: v114 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b
type: Reaction

327613
kinetic law: 090676
product: 090664
reactant: 090652
reactant: 090640
fast: false
reversible: true
name: v343 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

327839
kinetic law: 095934
product: 095922
reactant: 095910
reactant: 095898
fast: false
reversible: true
name: v456 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

111492
stoichiometry: 1.0
species: 326927
type: SpeciesReference

325908
is: GO:0005829
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

101374
stoichiometry: 1.0
species: 326641
type: SpeciesReference

075753
stoichiometry: 1.0
species: 325970
type: SpeciesReference

090204
stoichiometry: 1.0
species: 326347
type: SpeciesReference

328009
kinetic law: 099800
product: 099788
reactant: 099776
fast: false
reversible: true
name: v542 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
type: Reaction

096054
stoichiometry: 1.0
species: 326525
type: SpeciesReference

108808
stoichiometry: 1.0
species: 326861
type: SpeciesReference

327141
kinetic law: 079636
product: 079624
reactant: 079612
reactant: 079600
fast: false
reversible: true
name: v102 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

109988
stoichiometry: 1.0
species: 326885
type: SpeciesReference

329139
constant: true
value: 0.0
name: k55
type: Parameter

112819
stoichiometry: 1.0
species: 326913
type: SpeciesReference

084288
stoichiometry: 1.0
species: 326429
type: SpeciesReference

102651
stoichiometry: 1.0
species: 326681
type: SpeciesReference

105279
stoichiometry: 1.0
species: 326777
type: SpeciesReference

327163
kinetic law: 080164
product: 080152
reactant: 080140
reactant: 080128
fast: false
reversible: true
name: v113 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
type: Reaction

092034
stoichiometry: 1.0
species: 326551
type: SpeciesReference

100028
stoichiometry: 1.0
species: 326387
type: SpeciesReference

088590
stoichiometry: 1.0
species: 326148
type: SpeciesReference

075145
stoichiometry: 1.0
species: 325926
type: SpeciesReference

328085
kinetic law: 101169
product: 101157
reactant: 101145
fast: false
reversible: true
name: v584 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
type: Reaction

074988
stoichiometry: 1.0
species: 325920
type: SpeciesReference

326685
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

087998
stoichiometry: 1.0
species: 326217
type: SpeciesReference

328949
constant: false
value: 0.033
name: kd1
type: Parameter

096488
stoichiometry: 1.0
species: 326525
type: SpeciesReference

104375
stoichiometry: 1.0
species: 325952
type: SpeciesReference

081354
stoichiometry: 1.0
species: 326138
type: SpeciesReference

085362
stoichiometry: 1.0
species: 326341
type: SpeciesReference

090167
stoichiometry: 1.0
species: 326547
type: SpeciesReference

108676
stoichiometry: 1.0
species: 326827
type: SpeciesReference

326042
notes: (HRG:ErbB3):ErbB2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (HRG:ErbB3):ErbB2
type: Species

076415
stoichiometry: 1.0
species: 326010
type: SpeciesReference

088191
stoichiometry: 1.0
species: 326543
type: SpeciesReference

111168
stoichiometry: 1.0
species: 326921
type: SpeciesReference

326363
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos
type: Species

326607
notes: MEK#P#P:Pase2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP:Pase2
type: Species

326577
notes: Grb2:Sos , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 8.8914E7
in compartment: 325908
name: Grb2:Sos
type: Species

088468
stoichiometry: 1.0
species: 326397
type: SpeciesReference

327615
kinetic law: 090724
product: 090712
reactant: 090700
reactant: 090688
fast: false
reversible: true
name: v344 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

327569
kinetic law: 089587
product: 089574
reactant: 089561
reactant: 089548
fast: false
reversible: true
name: v321 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

326108
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos
type: Species

076187
stoichiometry: 1.0
species: 325980
type: SpeciesReference

327947
kinetic law: 098537
product: 098525
reactant: 098513
reactant: 098501
fast: false
reversible: true
name: v510 (MEK#P#P)_i + (ERK#P)_i -> MEK#P#P:ERK#P k52 kd44
type: Reaction

101482
stoichiometry: 1.0
species: 326641
type: SpeciesReference

329353
constant: false
value: 0.0150356
name: k116
type: Parameter

326253
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

087566
stoichiometry: 1.0
species: 326319
type: SpeciesReference

102966
stoichiometry: 1.0
species: 326707
type: SpeciesReference

326467
notes: (ErbB1:ErbB3)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P
type: Species

327411
kinetic law: 085760
product: 085748
reactant: 085736
reactant: 085724
fast: false
reversible: true
name: v242 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

326048
notes: ((HRG:ErbB3):ErbB2):ATP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: ((HRG:ErbB3):ErbB2):ATP
type: Species

078250
stoichiometry: 1.0
species: 326193
type: SpeciesReference

327721
kinetic law: 093104
product: 093092
reactant: 093080
reactant: 093068
fast: false
reversible: true
name: v397 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

328083
kinetic law: 101133
product: 101121
reactant: 101109
fast: false
reversible: true
name: v583 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60
type: Reaction

326713
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
type: Species

101615
stoichiometry: 1.0
species: 326313
type: SpeciesReference

328003
kinetic law: 099692
product: 099680
reactant: 099668
fast: false
reversible: true
name: v539 ErbB4 -> R_degraded k60b kd60b
type: Reaction

329035
constant: true
value: 1.1068E-5
name: k20
type: Parameter

099788
stoichiometry: 1.0
species: 326641
type: SpeciesReference

081586
stoichiometry: 1.0
species: 326391
type: SpeciesReference

327081
kinetic law: 078190
product: 078178
reactant: 078166
reactant: 078154
fast: false
reversible: true
name: v69 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

095717
stoichiometry: 1.0
species: 326523
type: SpeciesReference

077007
stoichiometry: 1.0
species: 326056
type: SpeciesReference

084806
stoichiometry: 1.0
species: 326521
type: SpeciesReference

326795
name: PIP3:Shp
type: Species
boundary condition: false
has part: CHEBI:16618
constant: false
has only substance units: true
initial amount: 0.0
in compartment: 325908
notes: PIP3:Shp , cytoplasm
initial concentration: NaN

329033
constant: true
value: 0.5
name: kd19
type: Parameter

090748
stoichiometry: 1.0
species: 326541
type: SpeciesReference

091480
stoichiometry: 1.0
species: 326331
type: SpeciesReference

100677
stoichiometry: 1.0
species: 326491
type: SpeciesReference

113156
stoichiometry: 1.0
species: 325980
type: SpeciesReference

080440
stoichiometry: 1.0
species: 326243
type: SpeciesReference

326251
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:cPP
type: Species

097321
stoichiometry: 1.0
species: 326253
type: SpeciesReference

105762
stoichiometry: 1.0
species: 326791
type: SpeciesReference

099920
stoichiometry: 1.0
species: 326393
type: SpeciesReference

075934
stoichiometry: 1.0
species: 325956
type: SpeciesReference

086183
stoichiometry: 1.0
species: 326209
type: SpeciesReference

111384
stoichiometry: 1.0
species: 325980
type: SpeciesReference

078466
stoichiometry: 1.0
species: 326211
type: SpeciesReference

099055
stoichiometry: 1.0
species: 326637
type: SpeciesReference

326469
notes: (ErbB1:ErbB4)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P
type: Species

113215
stoichiometry: 1.0
species: 326943
type: SpeciesReference

327949
kinetic law: 098585
product: 098573
reactant: 098561
reactant: 098549
fast: false
reversible: true
name: v511 (ERK#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK k53 kd53
type: Reaction

327723
kinetic law: 093152
product: 093140
reactant: 093128
reactant: 093116
fast: false
reversible: true
name: v398 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

082539
stoichiometry: 1.0
species: 326439
type: SpeciesReference

082322
stoichiometry: 1.0
species: 326062
type: SpeciesReference

328081
kinetic law: 101097
product: 101085
reactant: 101073
fast: false
reversible: true
name: v582 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
type: Reaction

327413
kinetic law: 085808
product: 085796
reactant: 085784
reactant: 085772
fast: false
reversible: true
name: v243 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

326255
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

326199
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

326715
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
type: Species

326046
notes: ((HRG:ErbB3):ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB3):ErbB2)
type: Species

328005
kinetic law: 099728
product: 099716
reactant: 099704
fast: false
reversible: true
name: v540 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
type: Reaction

105388
stoichiometry: 1.0
species: 325942
type: SpeciesReference

107423
stoichiometry: 1.0
species: 326819
type: SpeciesReference

327083
kinetic law: 078238
product: 078226
reactant: 078214
reactant: 078202
fast: false
reversible: true
name: v70 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
type: Reaction

100724
stoichiometry: 1.0
species: 326641
type: SpeciesReference

096330
stoichiometry: 1.0
species: 326511
type: SpeciesReference

329037
constant: true
value: 0.4
name: kd20
type: Parameter

326793
notes: PIP2 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 393639.0
in compartment: 325908
name: PIP2
type: Species

109291
stoichiometry: 1.0
species: 326689
type: SpeciesReference

092142
stoichiometry: 1.0
species: 326499
type: SpeciesReference

075253
stoichiometry: 1.0
species: 325936
type: SpeciesReference

327611
kinetic law: 090628
product: 090616
reactant: 090604
reactant: 090592
fast: false
reversible: true
name: v342 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

094201
stoichiometry: 1.0
species: 326395
type: SpeciesReference

093742
stoichiometry: 1.0
species: 326549
type: SpeciesReference

329249
constant: true
value: 1.38E-4
name: kd7
type: Parameter

329355
constant: true
value: 0.0
name: kd116
type: Parameter

113059
stoichiometry: 1.0
species: 325980
type: SpeciesReference

090010
stoichiometry: 1.0
species: 326549
type: SpeciesReference

108918
stoichiometry: 1.0
species: 326863
type: SpeciesReference

081245
stoichiometry: 1.0
species: 326377
type: SpeciesReference

326717
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
type: Species

326197
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

326104
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos
type: Species

111276
stoichiometry: 1.0
species: 325928
type: SpeciesReference

326257
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

327415
kinetic law: 085856
product: 085844
reactant: 085832
reactant: 085820
fast: false
reversible: true
name: v244 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

327725
kinetic law: 093200
product: 093188
reactant: 093176
reactant: 093164
fast: false
reversible: true
name: v399 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

079960
stoichiometry: 1.0
species: 326283
type: SpeciesReference

095994
stoichiometry: 1.0
species: 326497
type: SpeciesReference

327085
kinetic law: 078286
product: 078274
reactant: 078262
reactant: 078250
fast: false
reversible: true
name: v71 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
type: Reaction

102074
stoichiometry: 1.0
species: 326655
type: SpeciesReference

080224
stoichiometry: 1.0
species: 326309
type: SpeciesReference

098994
stoichiometry: 1.0
species: 326631
type: SpeciesReference

097223
stoichiometry: 1.0
species: 326277
type: SpeciesReference

081961
stoichiometry: 1.0
species: 326407
type: SpeciesReference

097296
stoichiometry: 1.0
species: 326577
type: SpeciesReference

085784
stoichiometry: 1.0
species: 326281
type: SpeciesReference

085844
stoichiometry: 1.0
species: 326319
type: SpeciesReference

326799
notes: PIP3:PTEN , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:PTEN
type: Species

085434
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327147
kinetic law: 079780
product: 079768
reactant: 079756
reactant: 079744
fast: false
reversible: true
name: v105 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b
type: Reaction

079261
stoichiometry: 1.0
species: 326277
type: SpeciesReference

104264
stoichiometry: 1.0
species: 326755
type: SpeciesReference

094659
stoichiometry: 1.0
species: 326501
type: SpeciesReference

329247
constant: true
value: 5.0E-5
name: k7
type: Parameter

093416
stoichiometry: 1.0
species: 326357
type: SpeciesReference

105497
stoichiometry: 1.0
species: 325918
type: SpeciesReference

329357
constant: true
value: 8.33E-8
name: k117
type: Parameter

091312
stoichiometry: 1.0
species: 326361
type: SpeciesReference

329243
constant: true
value: 0.1
name: kd96
type: Parameter

326259
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

328941
constant: false
value: 0.0
name: total ERK_PP
type: Parameter

327349
kinetic law: 084264
product: 084252
reactant: 084240
fast: false
reversible: true
name: v211 cPP + -> cPP k15 kd15
type: Reaction

327727
kinetic law: 093248
product: 093236
reactant: 093224
reactant: 093212
fast: false
reversible: true
name: v400 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

086748
stoichiometry: 1.0
species: 326397
type: SpeciesReference

327417
kinetic law: 085905
product: 085893
reactant: 085881
reactant: 085869
fast: false
reversible: true
name: v245 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

326106
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

327087
kinetic law: 078334
product: 078322
reactant: 078310
reactant: 078298
fast: false
reversible: true
name: v72 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
type: Reaction

103254
stoichiometry: 1.0
species: 326707
type: SpeciesReference

098693
stoichiometry: 1.0
species: 326629
type: SpeciesReference

094767
stoichiometry: 1.0
species: 326577
type: SpeciesReference

326719
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
type: Species

328001
kinetic law: 099656
product: 099644
reactant: 099632
fast: false
reversible: true
name: v538 ErbB2 -> R_degraded k60b kd60b
type: Reaction

095381
stoichiometry: 1.0
species: 326525
type: SpeciesReference

085591
stoichiometry: 1.0
species: 326521
type: SpeciesReference

095441
stoichiometry: 1.0
species: 326439
type: SpeciesReference

078178
stoichiometry: 1.0
species: 326158
type: SpeciesReference

327089
kinetic law: 078382
product: 078370
reactant: 078358
reactant: 078346
fast: false
reversible: true
name: v75 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
type: Reaction

110496
stoichiometry: 1.0
species: 326903
type: SpeciesReference

329031
constant: true
value: 1.667E-7
name: k19
type: Parameter

326797
notes: PTEN , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 56100.9
in compartment: 325908
name: PTEN
type: Species

086087
stoichiometry: 1.0
species: 326201
type: SpeciesReference

086736
stoichiometry: 1.0
species: 326541
type: SpeciesReference

327149
kinetic law: 079828
product: 079816
reactant: 079804
reactant: 079792
fast: false
reversible: true
name: v106 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b
type: Reaction

084059
stoichiometry: 1.0
species: 326493
type: SpeciesReference

089626
stoichiometry: 1.0
species: 326084
type: SpeciesReference

104773
stoichiometry: 1.0
species: 325924
type: SpeciesReference

086892
stoichiometry: 1.0
species: 326205
type: SpeciesReference

326195
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

080332
stoichiometry: 1.0
species: 326339
type: SpeciesReference

103688
stoichiometry: 1.0
species: 326745
type: SpeciesReference

329359
constant: true
value: 0.1
name: kd117
type: Parameter

329245
constant: true
value: 0.0
name: kd6b
type: Parameter

326193
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

082743
stoichiometry: 1.0
species: 326084
type: SpeciesReference

077840
stoichiometry: 1.0
species: 326130
type: SpeciesReference

079140
stoichiometry: 1.0
species: 326267
type: SpeciesReference

328189
kinetic law: 103387
product: 103375
reactant: 103363
reactant: 103351
fast: false
reversible: true
name: v636 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k68 kd68b
type: Reaction

076391
stoichiometry: 1.0
species: 326008
type: SpeciesReference

099272
stoichiometry: 1.0
species: 326421
type: SpeciesReference

075301
stoichiometry: 1.0
species: 325940
type: SpeciesReference

106075
stoichiometry: 1.0
species: 326014
type: SpeciesReference

104036
stoichiometry: 1.0
species: 326467
type: SpeciesReference

102748
stoichiometry: 1.0
species: 326689
type: SpeciesReference

107399
stoichiometry: 1.0
species: 326805
type: SpeciesReference

107062
stoichiometry: 1.0
species: 326805
type: SpeciesReference

080957
stoichiometry: 1.0
species: 326365
type: SpeciesReference

097983
stoichiometry: 1.0
species: 326603
type: SpeciesReference

328251
kinetic law: 104881
product: 104869
reactant: 104857
reactant: 104845
fast: false
reversible: true
name: v667 ErbB4 + Inh -> ErbB4:Inh k99 kd99
type: Reaction

109146
stoichiometry: 1.0
species: 326701
type: SpeciesReference

098477
stoichiometry: 1.0
species: 326621
type: SpeciesReference

106582
stoichiometry: 1.0
species: 326793
type: SpeciesReference

076947
stoichiometry: 1.0
species: 326054
type: SpeciesReference

327729
kinetic law: 093296
product: 093284
reactant: 093272
reactant: 093260
fast: false
reversible: true
name: v401 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

077165
stoichiometry: 1.0
species: 326074
type: SpeciesReference

112540
stoichiometry: 1.0
species: 326052
type: SpeciesReference

328107
kinetic law: 101567
product: 101555
reactant: 101543
fast: false
reversible: true
name: v595 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
type: Reaction

326249
notes: (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

329241
constant: true
value: 1.67E-6
name: k96
type: Parameter

100244
stoichiometry: 1.0
species: 326375
type: SpeciesReference

327359
kinetic law: 084505
product: 084493
reactant: 084481
reactant: 084469
fast: false
reversible: true
name: v216 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

326931
notes: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)
type: Species

111444
stoichiometry: 1.0
species: 326927
type: SpeciesReference

083227
stoichiometry: 1.0
species: 326471
type: SpeciesReference

326112
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

326191
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

326471
notes: (ErbB1:ErbB4)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P
type: Species

106930
stoichiometry: 1.0
species: 326695
type: SpeciesReference

096162
stoichiometry: 1.0
species: 326491
type: SpeciesReference

325910
constant: false
is: SBO:0000297
has only substance units: false
substance units: mole
is version of: GO:0005154
boundary condition: true
notes: EGF , medium
name: EGF
type: Species
initial concentration: 1.0E-11
initial amount: NaN
is version of: P01133
in compartment: 325904

328255
kinetic law: 104977
product: 104965
reactant: 104953
reactant: 104941
fast: false
reversible: true
name: v669 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P k101 kd101
type: Reaction

086111
stoichiometry: 1.0
species: 326539
type: SpeciesReference

108532
stoichiometry: 1.0
species: 326829
type: SpeciesReference

328187
kinetic law: 103339
product: 103327
reactant: 103315
reactant: 103303
fast: false
reversible: true
name: v635 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k68 kd68b
type: Reaction

103399
stoichiometry: 1.0
species: 326707
type: SpeciesReference

328253
kinetic law: 104929
product: 104917
reactant: 104905
reactant: 104893
fast: false
reversible: true
name: v668 ErbB3 + Inh -> ErbB3:Inh k100 kd100
type: Reaction

077381
stoichiometry: 1.0
species: 326092
type: SpeciesReference

108026
stoichiometry: 1.0
species: 326627
type: SpeciesReference

078502
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327357
kinetic law: 084457
product: 084445
reactant: 084433
reactant: 084421
fast: false
reversible: true
name: v215 2(EGF:ErbB1)#P:GAP + Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63
type: Reaction

327941
kinetic law: 098392
product: 098380
reactant: 098368
reactant: 098356
fast: false
reversible: true
name: v507 ERK + MEK#P#P -> ERK:MEK#P#P k52 kd44
type: Reaction

326933
notes: 2(EGF:ErbB1_h:ATP)-FullActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1_h:ATP)-FullActive
type: Species

112066
stoichiometry: 1.0
species: 325980
type: SpeciesReference

326114
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

326473
notes: 2(ErbB2)#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P
type: Species

328109
kinetic law: 101603
product: 101591
reactant: 101579
fast: false
reversible: true
name: v596 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
type: Reaction

087458
stoichiometry: 1.0
species: 326541
type: SpeciesReference

095922
stoichiometry: 1.0
species: 326096
type: SpeciesReference

081500
stoichiometry: 1.0
species: 326126
type: SpeciesReference

112927
stoichiometry: 1.0
species: 326939
type: SpeciesReference

094973
stoichiometry: 1.0
species: 326233
type: SpeciesReference

097077
stoichiometry: 1.0
species: 326395
type: SpeciesReference

083045
stoichiometry: 1.0
species: 326453
type: SpeciesReference

091516
stoichiometry: 1.0
species: 326541
type: SpeciesReference

110036
stoichiometry: 1.0
species: 326885
type: SpeciesReference

098801
stoichiometry: 1.0
species: 326631
type: SpeciesReference

098609
stoichiometry: 1.0
species: 326617
type: SpeciesReference

098127
stoichiometry: 1.0
species: 326603
type: SpeciesReference

110976
stoichiometry: 1.0
species: 326911
type: SpeciesReference

328599
kinetic law: 113275
product: 113263
reactant: 113251
reactant: 113239
fast: false
reversible: true
name: v862 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k123h kd123h
type: Reaction

328257
kinetic law: 105025
product: 105013
reactant: 105001
reactant: 104989
fast: false
reversible: true
name: v670 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) k101 kd101
type: Reaction

083877
stoichiometry: 1.0
species: 326507
type: SpeciesReference

089072
stoichiometry: 1.0
species: 326269
type: SpeciesReference

086952
stoichiometry: 1.0
species: 326156
type: SpeciesReference

093068
stoichiometry: 1.0
species: 326539
type: SpeciesReference

329039
constant: true
value: 3.67E-7
name: k21
type: Parameter

111900
stoichiometry: 1.0
species: 326687
type: SpeciesReference

105303
stoichiometry: 1.0
species: 326469
type: SpeciesReference

107207
stoichiometry: 1.0
species: 326805
type: SpeciesReference

328185
kinetic law: 103290
product: 103278
reactant: 103266
reactant: 103254
fast: false
reversible: true
name: v634 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k68 kd68b
type: Reaction

092551
stoichiometry: 1.0
species: 326457
type: SpeciesReference

097005
stoichiometry: 1.0
species: 326577
type: SpeciesReference

081793
stoichiometry: 1.0
species: 326102
type: SpeciesReference

094285
stoichiometry: 1.0
species: 326575
type: SpeciesReference

106654
stoichiometry: 1.0
species: 326725
type: SpeciesReference

326935
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)
type: Species

326475
notes: 2(ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P
type: Species

327355
kinetic law: 084409
product: 084397
reactant: 084385
reactant: 084373
fast: false
reversible: true
name: v214 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24
type: Reaction

085627
stoichiometry: 1.0
species: 326513
type: SpeciesReference

328509
kinetic law: 111084
product: 111072
reactant: 111060
reactant: 111048
fast: false
reversible: true
name: v796 EGF:ErbB1:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1:ErbB1_h:Inh k2 kd2
type: Reaction

081017
stoichiometry: 1.0
species: 326195
type: SpeciesReference

328103
kinetic law: 101494
product: 101482
reactant: 101470
fast: false
reversible: true
name: v593 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
type: Reaction

085217
stoichiometry: 1.0
species: 326229
type: SpeciesReference

327943
kinetic law: 098441
product: 098429
reactant: 098416
reactant: 098404
fast: false
reversible: true
name: v508 MEK#P#P + ERK#P -> ERK#P:MEK#P#P k52 kd44
type: Reaction

112131
stoichiometry: 1.0
species: 326020
type: SpeciesReference

080800
stoichiometry: 1.0
species: 326309
type: SpeciesReference

100509
stoichiometry: 1.0
species: 326641
type: SpeciesReference

092625
stoichiometry: 1.0
species: 326489
type: SpeciesReference

106822
stoichiometry: 1.0
species: 326805
type: SpeciesReference

107858
stoichiometry: 1.0
species: 326833
type: SpeciesReference

102146
stoichiometry: 1.0
species: 326627
type: SpeciesReference

110616
stoichiometry: 1.0
species: 326519
type: SpeciesReference

102290
stoichiometry: 1.0
species: 326629
type: SpeciesReference

087121
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328259
kinetic law: 105073
product: 105061
reactant: 105049
reactant: 105037
fast: false
reversible: true
name: v671 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101
type: Reaction

099704
stoichiometry: 1.0
species: 326405
type: SpeciesReference

095213
stoichiometry: 1.0
species: 326319
type: SpeciesReference

079816
stoichiometry: 1.0
species: 326295
type: SpeciesReference

096740
stoichiometry: 1.0
species: 326076
type: SpeciesReference

088626
stoichiometry: 1.0
species: 326205
type: SpeciesReference

082852
stoichiometry: 1.0
species: 325938
type: SpeciesReference

328183
kinetic law: 103242
product: 103230
reactant: 103218
reactant: 103206
fast: false
reversible: true
name: v633 PIP3 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
type: Reaction

092613
stoichiometry: 1.0
species: 326485
type: SpeciesReference

077599
stoichiometry: 1.0
species: 326110
type: SpeciesReference

110760
stoichiometry: 1.0
species: 326905
type: SpeciesReference

326110
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

328507
kinetic law: 111036
product: 111024
reactant: 111012
reactant: 111000
fast: false
reversible: true
name: v795 EGF + ErbB1_h:Inh -> EGF:ErbB1_h:Inh k1 kd1
type: Reaction

327421
kinetic law: 086002
product: 085990
reactant: 085978
reactant: 085966
fast: false
reversible: true
name: v247 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

329351
constant: true
value: 1.0
name: kd115
type: Parameter

096969
stoichiometry: 1.0
species: 326533
type: SpeciesReference

326477
notes: (ErbB3:ErbB2)#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P
type: Species

326937
notes: (EGF:ErbB1:Inh::EGF:ErbB1_h:Inh) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:Inh::EGF:ErbB1_h:Inh)
type: Species

326711
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
type: Species

327353
kinetic law: 084361
product: 084349
reactant: 084337
reactant: 084325
fast: false
reversible: true
name: v213 Grb2 + (Shc#P) -> (Shc#P):Grb2 k16 kd24
type: Reaction

328441
kinetic law: 109459
product: 109447
reactant: 109435
reactant: 109423
fast: false
reversible: true
name: v762 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
type: Reaction

111975
stoichiometry: 1.0
species: 326008
type: SpeciesReference

097657
stoichiometry: 1.0
species: 326591
type: SpeciesReference

328105
kinetic law: 101530
product: 101518
reactant: 101506
fast: false
reversible: true
name: v594 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
type: Reaction

079744
stoichiometry: 1.0
species: 326309
type: SpeciesReference

327945
kinetic law: 098489
product: 098477
reactant: 098465
reactant: 098453
fast: false
reversible: true
name: v509 ERK + (MEK#P#P)_i -> MEK#P#P:ERK k52 kd44
type: Reaction

325916
is: SBO:0000297
has only substance units: true
type: Species
initial amount: 0.0
name: (ErbB2:ErbB3)
has part: P04626
boundary condition: false
has part: P21860
notes: (ErbB2:ErbB3) , plasma membrane
constant: false
initial concentration: NaN
in compartment: 325898

327835
kinetic law: 095838
product: 095826
reactant: 095814
reactant: 095802
fast: false
reversible: true
name: v454 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

328595
kinetic law: 113180
product: 113168
reactant: 113156
reactant: 113144
fast: false
reversible: true
name: v860 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k123h kd123h
type: Reaction

093176
stoichiometry: 1.0
species: 326096
type: SpeciesReference

326601
notes: (MEK#P#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_PP)_i
type: Species

326827
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i
type: Species

326583
notes: Raf#P:Pase1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Raf_P:Pase1
type: Species

098958
stoichiometry: 1.0
species: 326637
type: SpeciesReference

079333
stoichiometry: 1.0
species: 326283
type: SpeciesReference

083443
stoichiometry: 1.0
species: 326491
type: SpeciesReference

327575
kinetic law: 089743
product: 089730
reactant: 089717
reactant: 089704
fast: false
reversible: true
name: v324 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

088251
stoichiometry: 1.0
species: 326064
type: SpeciesReference

107315
stoichiometry: 1.0
species: 326018
type: SpeciesReference

327351
kinetic law: 084312
product: 084300
reactant: 084288
reactant: 084276
fast: false
reversible: true
name: v212 Grb2 + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63
type: Reaction

104411
stoichiometry: 1.0
species: 326755
type: SpeciesReference

326695
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P
type: Species

095369
stoichiometry: 1.0
species: 326429
type: SpeciesReference

080092
stoichiometry: 1.0
species: 326329
type: SpeciesReference

328443
kinetic law: 109507
product: 109495
reactant: 109483
reactant: 109471
fast: false
reversible: true
name: v763 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
type: Reaction

111864
stoichiometry: 1.0
species: 325980
type: SpeciesReference

328505
kinetic law: 110988
product: 110976
reactant: 110964
reactant: 110952
fast: false
reversible: true
name: v794 ErbB1_h + Inh -> ErbB1_h:Inh k97c kd97c
type: Reaction

098235
stoichiometry: 1.0
species: 326605
type: SpeciesReference

112288
stoichiometry: 1.0
species: 326032
type: SpeciesReference

094863
stoichiometry: 1.0
species: 326577
type: SpeciesReference

081684
stoichiometry: 1.0
species: 326395
type: SpeciesReference

110820
stoichiometry: 1.0
species: 326907
type: SpeciesReference

327161
kinetic law: 080116
product: 080104
reactant: 080092
reactant: 080080
fast: false
reversible: true
name: v112 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
type: Reaction

326939
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive
type: Species

328181
kinetic law: 103194
product: 103182
reactant: 103170
reactant: 103158
fast: false
reversible: true
name: v632 PIP3 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
type: Reaction

095814
stoichiometry: 1.0
species: 326525
type: SpeciesReference

109903
stoichiometry: 1.0
species: 326855
type: SpeciesReference

082033
stoichiometry: 1.0
species: 326082
type: SpeciesReference

076729
stoichiometry: 1.0
species: 326036
type: SpeciesReference

106364
stoichiometry: 1.0
species: 326719
type: SpeciesReference

328597
kinetic law: 113227
product: 113215
reactant: 113203
reactant: 113191
fast: false
reversible: true
name: v861 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k123 kd123
type: Reaction

105049
stoichiometry: 1.0
species: 326072
type: SpeciesReference

327837
kinetic law: 095886
product: 095874
reactant: 095862
reactant: 095850
fast: false
reversible: true
name: v455 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

097549
stoichiometry: 1.0
species: 326579
type: SpeciesReference

089974
stoichiometry: 1.0
species: 326397
type: SpeciesReference

083757
stoichiometry: 1.0
species: 326465
type: SpeciesReference

325918
initial amount: 0.0
has only substance units: true
type: Species
has part: P04626
boundary condition: false
has part: P21860
constant: false
notes: (ErbB3:ErbB2)#P , plasma membrane
has version: C00562
name: (ErbB3:ErbB2)_P
initial concentration: NaN
in compartment: 325898

085059
stoichiometry: 1.0
species: 326537
type: SpeciesReference

327577
kinetic law: 089795
product: 089782
reactant: 089769
reactant: 089756
fast: false
reversible: true
name: v325 Ras_activated:GTP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

326603
in compartment: 325908
boundary condition: false
initial amount: 124480.0
notes: Pase2 , cytoplasm
type: Species
is version of: Q13115
name: Pase2
initial concentration: NaN
constant: false
has only substance units: true

326585
notes: (MEK#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_P)_i
type: Species

326829
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:ERK_PP
type: Species

104144
stoichiometry: 1.0
species: 326761
type: SpeciesReference

326691
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P
type: Species

076874
stoichiometry: 1.0
species: 326048
type: SpeciesReference

084914
stoichiometry: 1.0
species: 326531
type: SpeciesReference

328101
kinetic law: 101458
product: 101446
reactant: 101434
fast: false
reversible: true
name: v592 (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60
type: Reaction

328503
kinetic law: 110940
product: 110928
reactant: 110916
reactant: 110904
fast: false
reversible: true
name: v793 ErbB1:ATP + (HRG:ErbB4) -> (HRG:ErbB4:ErbB1) k120b kd120
type: Reaction

326693
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K
type: Species

328445
kinetic law: 109555
product: 109543
reactant: 109531
reactant: 109519
fast: false
reversible: true
name: v764 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
type: Reaction

096812
stoichiometry: 1.0
species: 326577
type: SpeciesReference

080128
stoichiometry: 1.0
species: 326309
type: SpeciesReference

088517
stoichiometry: 1.0
species: 326395
type: SpeciesReference

082961
stoichiometry: 1.0
species: 326445
type: SpeciesReference

326357
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

329133
constant: true
value: 0.28
name: kd53
type: Parameter

084686
stoichiometry: 1.0
species: 326381
type: SpeciesReference

100136
stoichiometry: 1.0
species: 326381
type: SpeciesReference

083335
stoichiometry: 1.0
species: 326479
type: SpeciesReference

327203
kinetic law: 081125
product: 081113
reactant: 081101
reactant: 081089
fast: false
reversible: true
name: v136 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

327831
kinetic law: 095741
product: 095729
reactant: 095717
reactant: 095705
fast: false
reversible: true
name: v452 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
type: Reaction

112416
stoichiometry: 1.0
species: 325918
type: SpeciesReference

326823
notes: 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):ERK_PP_i
type: Species

087085
stoichiometry: 1.0
species: 326359
type: SpeciesReference

093284
stoichiometry: 1.0
species: 326397
type: SpeciesReference

088010
stoichiometry: 1.0
species: 326221
type: SpeciesReference

079031
stoichiometry: 1.0
species: 326056
type: SpeciesReference

102434
stoichiometry: 1.0
species: 326627
type: SpeciesReference

078658
stoichiometry: 1.0
species: 326227
type: SpeciesReference

077731
stoichiometry: 1.0
species: 326056
type: SpeciesReference

325912
type: Species
is: SBO:0000297
initial concentration: NaN
has part: CHEBI:15422
notes: ErbB1:ATP , plasma membrane
initial amount: 0.0
has only substance units: true
in compartment: 325898
has part: P00533
constant: false
boundary condition: false
name: ErbB1:ATP

103315
stoichiometry: 1.0
species: 326721
type: SpeciesReference

102218
stoichiometry: 1.0
species: 326661
type: SpeciesReference

091180
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328447
kinetic law: 109603
product: 109591
reactant: 109579
reactant: 109567
fast: false
reversible: true
name: v765 AKT#P#P + Raf#P -> AKT:P:P:Raf:P:Ser k114 kd114
type: Reaction

328501
kinetic law: 110892
product: 110880
reactant: 110868
reactant: 110856
fast: false
reversible: true
name: v792 ErbB1:ATP + (HRG:ErbB3) -> (HRG:ErbB3:ErbB1) k120b kd120
type: Reaction

111756
stoichiometry: 1.0
species: 326465
type: SpeciesReference

101591
stoichiometry: 1.0
species: 326641
type: SpeciesReference

097705
stoichiometry: 1.0
species: 326593
type: SpeciesReference

109483
stoichiometry: 1.0
species: 326701
type: SpeciesReference

098320
stoichiometry: 1.0
species: 326595
type: SpeciesReference

328591
kinetic law: 113083
product: 113071
reactant: 113059
reactant: 113047
fast: false
reversible: true
name: v858 EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k122 kd122
type: Reaction

082635
stoichiometry: 1.0
species: 326072
type: SpeciesReference

103976
stoichiometry: 1.0
species: 326739
type: SpeciesReference

086520
stoichiometry: 1.0
species: 326409
type: SpeciesReference

085145
stoichiometry: 1.0
species: 326521
type: SpeciesReference

095021
stoichiometry: 1.0
species: 326347
type: SpeciesReference

107171
stoichiometry: 1.0
species: 326006
type: SpeciesReference

327571
kinetic law: 089639
product: 089626
reactant: 089613
reactant: 089600
fast: false
reversible: true
name: v322 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

077623
stoichiometry: 1.0
species: 326112
type: SpeciesReference

108893
stoichiometry: 1.0
species: 326541
type: SpeciesReference

085290
stoichiometry: 1.0
species: 326521
type: SpeciesReference

074902
stoichiometry: 1.0
species: 325912
type: SpeciesReference

327573
kinetic law: 089691
product: 089678
reactant: 089665
reactant: 089652
fast: false
reversible: true
name: v323 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

084325
stoichiometry: 1.0
species: 326521
type: SpeciesReference

087890
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327201
kinetic law: 081077
product: 081065
reactant: 081053
reactant: 081041
fast: false
reversible: true
name: v135 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

095657
stoichiometry: 1.0
species: 326495
type: SpeciesReference

091240
stoichiometry: 1.0
species: 326197
type: SpeciesReference

329131
constant: true
value: 0.033
name: kd52
type: Parameter

326825
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP
type: Species

098549
stoichiometry: 1.0
species: 326623
type: SpeciesReference

083901
stoichiometry: 1.0
species: 326493
type: SpeciesReference

326359
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos
type: Species

096524
stoichiometry: 1.0
species: 326511
type: SpeciesReference

327833
kinetic law: 095789
product: 095777
reactant: 095765
reactant: 095753
fast: false
reversible: true
name: v453 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
type: Reaction

085918
stoichiometry: 1.0
species: 326539
type: SpeciesReference

088034
stoichiometry: 1.0
species: 326545
type: SpeciesReference

325914
is: SBO:0000297
type: Species
initial amount: 0.0
name: EGF:ErbB1:ATP
initial concentration: NaN
notes: EGF:ErbB1:ATP , plasma membrane
has part: CHEBI:15422
has only substance units: true
constant: false
has version: P01133
in compartment: 325898
has part: P00533
boundary condition: false

097113
stoichiometry: 1.0
species: 326489
type: SpeciesReference

078755
stoichiometry: 1.0
species: 326235
type: SpeciesReference

328449
kinetic law: 109651
product: 109639
reactant: 109627
reactant: 109615
fast: false
reversible: true
name: v766 AKT#P#P + (Raf#P)_i -> AKT:P:P:Raf:P:Ser_i k114 kd114
type: Reaction

075399
stoichiometry: 1.0
species: 325948
type: SpeciesReference

099164
stoichiometry: 1.0
species: 325936
type: SpeciesReference

105907
stoichiometry: 1.0
species: 326136
type: SpeciesReference

104520
stoichiometry: 1.0
species: 325936
type: SpeciesReference

097790
stoichiometry: 1.0
species: 326573
type: SpeciesReference

077490
stoichiometry: 1.0
species: 326056
type: SpeciesReference

328593
kinetic law: 113132
product: 113120
reactant: 113108
reactant: 113096
fast: false
reversible: true
name: v859 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k123 kd123
type: Reaction

326581
notes: (Raf#P:Pase1)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (Raf_P:Pase1)_i
type: Species

105665
stoichiometry: 1.0
species: 325968
type: SpeciesReference

086447
stoichiometry: 1.0
species: 326541
type: SpeciesReference

329191
constant: true
value: 0.1
name: kd69
type: Parameter

328937
constant: true
units: item
value: 1080000.0
name: total EGF receptor
type: Parameter

327755
kinetic law: 093923
product: 093911
reactant: 093899
reactant: 093887
fast: false
reversible: true
name: v414 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

327687
kinetic law: 092455
product: 092443
reactant: 092431
reactant: 092419
fast: false
reversible: true
name: v380 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22
type: Reaction

075133
stoichiometry: 1.0
species: 325926
type: SpeciesReference

327009
kinetic law: 076451
product: 076439
reactant: 076427
reactant: 076415
fast: false
reversible: true
name: v32 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

326078
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

108376
stoichiometry: 1.0
species: 326851
type: SpeciesReference

080620
stoichiometry: 1.0
species: 326351
type: SpeciesReference

329127
constant: true
value: 4.74801E-8
name: k50
type: Parameter

327175
kinetic law: 080452
product: 080440
reactant: 080428
reactant: 080416
fast: false
reversible: true
name: v120 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

080584
stoichiometry: 1.0
species: 326231
type: SpeciesReference

107544
stoichiometry: 1.0
species: 326627
type: SpeciesReference

084252
stoichiometry: 1.0
species: 326056
type: SpeciesReference

093948
stoichiometry: 1.0
species: 326575
type: SpeciesReference

078586
stoichiometry: 1.0
species: 326221
type: SpeciesReference

082419
stoichiometry: 1.0
species: 326425
type: SpeciesReference

088432
stoichiometry: 1.0
species: 326545
type: SpeciesReference

101977
stoichiometry: 1.0
species: 326651
type: SpeciesReference

327829
kinetic law: 095693
product: 095681
reactant: 095669
reactant: 095657
fast: false
reversible: true
name: v451 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

327603
kinetic law: 090432
product: 090420
reactant: 090408
reactant: 090396
fast: false
reversible: true
name: v338 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

111156
stoichiometry: 1.0
species: 326919
type: SpeciesReference

327557
kinetic law: 089277
product: 089265
reactant: 089253
reactant: 089241
fast: false
reversible: true
name: v315 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

099091
stoichiometry: 1.0
species: 326623
type: SpeciesReference

326589
is version of: A4QPA9
initial concentration: NaN
is version of: Q02750
type: Species
initial amount: 3020000.0
notes: MEK , cytoplasm
has only substance units: true
name: MEK
in compartment: 325908
boundary condition: false
constant: false
is described by: http://identifiers.org/omim/176872

326375
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

085398
stoichiometry: 1.0
species: 326457
type: SpeciesReference

101037
stoichiometry: 1.0
species: 326451
type: SpeciesReference

104387
stoichiometry: 1.0
species: 326769
type: SpeciesReference

096452
stoichiometry: 1.0
species: 326459
type: SpeciesReference

090131
stoichiometry: 1.0
species: 326351
type: SpeciesReference

110327
stoichiometry: 1.0
species: 326885
type: SpeciesReference

327007
kinetic law: 076403
product: 076391
reactant: 076379
reactant: 076367
fast: false
reversible: true
name: v31 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

089678
stoichiometry: 1.0
species: 326415
type: SpeciesReference

328935
constant: false
units: item
value: NaN
type: Parameter

326651
notes: (ErbB3:ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)
type: Species

327899
kinetic law: 097381
product: 097369
reactant: 097357
reactant: 097345
fast: false
reversible: true
name: v486 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

329193
constant: true
value: 6.67E-7
name: k70
type: Parameter

327685
kinetic law: 092407
product: 092395
reactant: 092383
reactant: 092371
fast: false
reversible: true
name: v379 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22
type: Reaction

106546
stoichiometry: 1.0
species: 326709
type: SpeciesReference

327753
kinetic law: 093875
product: 093863
reactant: 093851
reactant: 093839
fast: false
reversible: true
name: v413 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

107496
stoichiometry: 1.0
species: 326707
type: SpeciesReference

329129
constant: true
value: 0.252982
name: kd50
type: Parameter

094321
stoichiometry: 1.0
species: 326507
type: SpeciesReference

097465
stoichiometry: 1.0
species: 326583
type: SpeciesReference

109435
stoichiometry: 1.0
species: 326697
type: SpeciesReference

091650
stoichiometry: 1.0
species: 326321
type: SpeciesReference

089717
stoichiometry: 1.0
species: 326411
type: SpeciesReference

109327
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327827
kinetic law: 095645
product: 095633
reactant: 095621
reactant: 095609
fast: false
reversible: true
name: v450 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
type: Reaction

326373
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

078370
stoichiometry: 1.0
species: 326203
type: SpeciesReference

326587
notes: (MEK#P:Raf#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK_P:Raf_P)_i
type: Species

327601
kinetic law: 090384
product: 090372
reactant: 090360
reactant: 090348
fast: false
reversible: true
name: v337 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

076379
stoichiometry: 1.0
species: 325980
type: SpeciesReference

327177
kinetic law: 080500
product: 080488
reactant: 080476
reactant: 080464
fast: false
reversible: true
name: v121 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

327555
kinetic law: 089229
product: 089217
reactant: 089204
reactant: 089192
fast: false
reversible: true
name: v314 (Ras_activated:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

083492
stoichiometry: 1.0
species: 326495
type: SpeciesReference

106124
stoichiometry: 1.0
species: 326018
type: SpeciesReference

111012
stoichiometry: 1.0
species: 326911
type: SpeciesReference

096728
stoichiometry: 1.0
species: 326437
type: SpeciesReference

327897
kinetic law: 097333
product: 097321
reactant: 097308
reactant: 097296
fast: false
reversible: true
name: v485 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

329195
constant: true
value: 0.1
name: kd70
type: Parameter

327683
kinetic law: 092359
product: 092346
reactant: 092334
reactant: 092322
fast: false
reversible: true
name: v378 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
type: Reaction

327751
kinetic law: 093827
product: 093815
reactant: 093803
reactant: 093791
fast: false
reversible: true
name: v412 Ras_activated:GTP + Raf#P -> Raf:Ras:GTP k29 kd29
type: Reaction

328933
constant: false
units: item
value: NaN
type: Parameter

326653
notes: (ErbB4:ErbB2) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)
type: Species

110061
stoichiometry: 1.0
species: 326897
type: SpeciesReference

327005
kinetic law: 076355
product: 076343
reactant: 076331
reactant: 076319
fast: false
reversible: true
name: v30 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

094622
stoichiometry: 1.0
species: 326577
type: SpeciesReference

093815
stoichiometry: 1.0
species: 326567
type: SpeciesReference

097681
stoichiometry: 1.0
species: 326589
type: SpeciesReference

093997
stoichiometry: 1.0
species: 326575
type: SpeciesReference

087626
stoichiometry: 1.0
species: 326293
type: SpeciesReference

082274
stoichiometry: 1.0
species: 326058
type: SpeciesReference

329123
constant: true
value: 0.112387
name: kd49
type: Parameter

099416
stoichiometry: 1.0
species: 326439
type: SpeciesReference

327179
kinetic law: 080548
product: 080536
reactant: 080524
reactant: 080512
fast: false
reversible: true
name: v122 cPP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b
type: Reaction

326379
notes: (ErbB1:ErbB3)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:Grb2
type: Species

078057
stoichiometry: 1.0
species: 326148
type: SpeciesReference

327607
kinetic law: 090530
product: 090517
reactant: 090504
reactant: 090492
fast: false
reversible: true
name: v340 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

089821
stoichiometry: 1.0
species: 326104
type: SpeciesReference

327229
kinetic law: 081757
product: 081745
reactant: 081733
reactant: 081720
fast: false
reversible: true
name: v149 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
type: Reaction

100328
stoichiometry: 1.0
species: 326641
type: SpeciesReference

079912
stoichiometry: 1.0
species: 326287
type: SpeciesReference

103134
stoichiometry: 1.0
species: 326715
type: SpeciesReference

104216
stoichiometry: 1.0
species: 326755
type: SpeciesReference

098573
stoichiometry: 1.0
species: 326621
type: SpeciesReference

327681
kinetic law: 092310
product: 092298
reactant: 092286
reactant: 092274
fast: false
reversible: true
name: v377 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
type: Reaction

326074
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:cPP
type: Species

103543
stoichiometry: 1.0
species: 326707
type: SpeciesReference

089561
stoichiometry: 1.0
species: 326547
type: SpeciesReference

328931
constant: false
units: item
value: NaN
type: Parameter

327895
kinetic law: 097284
product: 097272
reactant: 097259
reactant: 097247
fast: false
reversible: true
name: v484 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
type: Reaction

326076
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos
type: Species

093693
stoichiometry: 1.0
species: 326545
type: SpeciesReference

099356
stoichiometry: 1.0
species: 326641
type: SpeciesReference

104180
stoichiometry: 1.0
species: 326475
type: SpeciesReference

329197
constant: true
value: 0.0
name: k71
type: Parameter

078310
stoichiometry: 1.0
species: 326056
type: SpeciesReference

085314
stoichiometry: 1.0
species: 326245
type: SpeciesReference

326655
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(ERK_PP)
type: Species

326519
notes: (HRG:ErbB3) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (HRG:ErbB3)
type: Species

326439
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P)
type: Species

327003
kinetic law: 076307
product: 076295
reactant: 076283
reactant: 076271
fast: false
reversible: true
name: v29 ErbB2:ErbB2#P + ATP -> ErbB2:ErbB2#P:ATP k122 kd122
type: Reaction

101797
stoichiometry: 1.0
species: 325960
type: SpeciesReference

104893
stoichiometry: 1.0
species: 325942
type: SpeciesReference

092805
stoichiometry: 1.0
species: 326529
type: SpeciesReference

094417
stoichiometry: 1.0
species: 326509
type: SpeciesReference

329125
constant: true
value: 0.0
name: k49
type: Parameter

097175
stoichiometry: 1.0
species: 326355
type: SpeciesReference

092383
stoichiometry: 1.0
species: 326509
type: SpeciesReference

091950
stoichiometry: 1.0
species: 326503
type: SpeciesReference

087482
stoichiometry: 1.0
species: 326335
type: SpeciesReference

326377
notes: (ErbB1:ErbB4)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2
type: Species

112867
stoichiometry: 1.0
species: 325926
type: SpeciesReference

108484
stoichiometry: 1.0
species: 326835
type: SpeciesReference

327605
kinetic law: 090480
product: 090468
reactant: 090456
reactant: 090444
fast: false
reversible: true
name: v339 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

327559
kinetic law: 089327
product: 089315
reactant: 089302
reactant: 089289
fast: false
reversible: true
name: v316 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

088106
stoichiometry: 1.0
species: 326409
type: SpeciesReference

095874
stoichiometry: 1.0
species: 326092
type: SpeciesReference

103086
stoichiometry: 1.0
species: 326713
type: SpeciesReference

109639
stoichiometry: 1.0
species: 326879
type: SpeciesReference

329349
constant: true
value: 0.0
name: k115
type: Parameter

103206
stoichiometry: 1.0
species: 326707
type: SpeciesReference

104821
stoichiometry: 1.0
species: 325968
type: SpeciesReference

101253
stoichiometry: 1.0
species: 326331
type: SpeciesReference

103760
stoichiometry: 1.0
species: 326741
type: SpeciesReference

328037
kinetic law: 100304
product: 100292
reactant: 100280
fast: false
reversible: true
name: v556 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

077345
stoichiometry: 1.0
species: 326056
type: SpeciesReference

097393
stoichiometry: 1.0
species: 326579
type: SpeciesReference

083155
stoichiometry: 1.0
species: 326463
type: SpeciesReference

088856
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327075
kinetic law: 078045
product: 078033
reactant: 078021
reactant: 078009
fast: false
reversible: true
name: v66 (ErbB1:ErbB4)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k4b kd4
type: Reaction

094779
stoichiometry: 1.0
species: 326209
type: SpeciesReference

327001
kinetic law: 076259
product: 076247
reactant: 076235
reactant: 076223
fast: false
reversible: true
name: v28 EGF:ErbB1:ErbB4 + ATP -> EGF:ErbB1:ErbB4:ATP k122 kd122
type: Reaction

326941
notes: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive
type: Species

326437
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P)
type: Species

080140
stoichiometry: 1.0
species: 326331
type: SpeciesReference

106015
stoichiometry: 1.0
species: 326801
type: SpeciesReference

326657
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(ERK_PP)
type: Species

327289
kinetic law: 082985
product: 082973
reactant: 082961
fast: false
reversible: true
name: v180 (ErbB4:ErbB2)#P:GAP:Shc -> (ErbB4:ErbB2)#P:GAP:Shc k6 kd6
type: Reaction

326223
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
type: Species

329199
constant: true
value: 25.2
name: kd71
type: Parameter

098043
stoichiometry: 1.0
species: 326607
type: SpeciesReference

327337
kinetic law: 083986
product: 083974
reactant: 083961
reactant: 083949
fast: false
reversible: true
name: v204 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
type: Reaction

086808
stoichiometry: 1.0
species: 326389
type: SpeciesReference

093887
stoichiometry: 1.0
species: 326431
type: SpeciesReference

108700
stoichiometry: 1.0
species: 326627
type: SpeciesReference

329347
constant: true
value: 0.1
name: kd114
type: Parameter

080368
stoichiometry: 1.0
species: 326309
type: SpeciesReference

103652
stoichiometry: 1.0
species: 326733
type: SpeciesReference

084047
stoichiometry: 1.0
species: 326475
type: SpeciesReference

086880
stoichiometry: 1.0
species: 326541
type: SpeciesReference

327077
kinetic law: 078093
product: 078081
reactant: 078069
reactant: 078057
fast: false
reversible: true
name: v67 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

329043
constant: true
value: 1.39338E-7
name: k22
type: Parameter

110484
stoichiometry: 1.0
species: 325942
type: SpeciesReference

327113
kinetic law: 078959
product: 078947
reactant: 078935
reactant: 078923
fast: false
reversible: true
name: v88 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
type: Reaction

108050
stoichiometry: 1.0
species: 326841
type: SpeciesReference

086700
stoichiometry: 1.0
species: 326399
type: SpeciesReference

078166
stoichiometry: 1.0
species: 326056
type: SpeciesReference

101410
stoichiometry: 1.0
species: 326641
type: SpeciesReference

084421
stoichiometry: 1.0
species: 326431
type: SpeciesReference

112528
stoichiometry: 1.0
species: 325980
type: SpeciesReference

328035
kinetic law: 100268
product: 100256
reactant: 100244
fast: false
reversible: true
name: v555 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

085772
stoichiometry: 1.0
species: 326539
type: SpeciesReference

102062
stoichiometry: 1.0
species: 326060
type: SpeciesReference

105061
stoichiometry: 1.0
species: 326669
type: SpeciesReference

327073
kinetic law: 077997
product: 077985
reactant: 077973
reactant: 077961
fast: false
reversible: true
name: v65 (ErbB1:ErbB3)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k4b kd4
type: Reaction

100905
stoichiometry: 1.0
species: 326641
type: SpeciesReference

079996
stoichiometry: 1.0
species: 326325
type: SpeciesReference

089782
stoichiometry: 1.0
species: 326124
type: SpeciesReference

327339
kinetic law: 084035
product: 084023
reactant: 084011
reactant: 083998
fast: false
reversible: true
name: v205 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8
type: Reaction

326221
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

106606
stoichiometry: 1.0
species: 326723
type: SpeciesReference

326729
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)6
type: Species

326435
notes: 2(EGF:ErbB1)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:Shc
type: Species

326659
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:ERK_PP
type: Species

105485
stoichiometry: 1.0
species: 326779
type: SpeciesReference

095561
stoichiometry: 1.0
species: 326503
type: SpeciesReference

082382
stoichiometry: 1.0
species: 325912
type: SpeciesReference

104712
stoichiometry: 1.0
species: 326771
type: SpeciesReference

329345
notes: %AKT inhibiert Raf
constant: true
value: 4.98816E-6
name: k114
type: Parameter

083407
stoichiometry: 1.0
species: 326487
type: SpeciesReference

329041
constant: true
value: 0.23
name: kd21
type: Parameter

110544
stoichiometry: 1.0
species: 326905
type: SpeciesReference

079430
stoichiometry: 1.0
species: 326291
type: SpeciesReference

327111
kinetic law: 078911
product: 078899
reactant: 078887
reactant: 078875
fast: false
reversible: true
name: v87 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
type: Reaction

110279
stoichiometry: 1.0
species: 326885
type: SpeciesReference

080296
stoichiometry: 1.0
species: 326255
type: SpeciesReference

328033
kinetic law: 100232
product: 100220
reactant: 100208
fast: false
reversible: true
name: v554 (ErbB1:ErbB4)#P:GAP:Grb2 -> R_degraded k60b kd60
type: Reaction

094105
stoichiometry: 1.0
species: 326399
type: SpeciesReference

327071
kinetic law: 077949
product: 077937
reactant: 077925
reactant: 077913
fast: false
reversible: true
name: v64 (ErbB1:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k4b kd4
type: Reaction

329049
constant: true
value: 0.06
name: kd23
type: Parameter

109867
stoichiometry: 1.0
species: 326889
type: SpeciesReference

076657
stoichiometry: 1.0
species: 326030
type: SpeciesReference

326371
notes: (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

082828
stoichiometry: 1.0
species: 325954
type: SpeciesReference

082491
stoichiometry: 1.0
species: 326433
type: SpeciesReference

326433
notes: 2(EGF:ErbB1)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Shc
type: Species

326727
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)5
type: Species

113203
stoichiometry: 1.0
species: 325980
type: SpeciesReference

088324
stoichiometry: 1.0
species: 326104
type: SpeciesReference

089000
stoichiometry: 1.0
species: 326545
type: SpeciesReference

086171
stoichiometry: 1.0
species: 326144
type: SpeciesReference

111372
stoichiometry: 1.0
species: 326425
type: SpeciesReference

327449
kinetic law: 086676
product: 086664
reactant: 086652
reactant: 086640
fast: false
reversible: true
name: v261 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

082527
stoichiometry: 1.0
species: 326437
type: SpeciesReference

327759
kinetic law: 094021
product: 094009
reactant: 093997
reactant: 093985
fast: false
reversible: true
name: v416 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

096343
stoichiometry: 1.0
species: 326523
type: SpeciesReference

081233
stoichiometry: 1.0
species: 326309
type: SpeciesReference

090022
stoichiometry: 1.0
species: 326395
type: SpeciesReference

329343
constant: true
value: 177.828
name: kd113
type: Parameter

108266
stoichiometry: 1.0
species: 326629
type: SpeciesReference

084144
stoichiometry: 1.0
species: 326423
type: SpeciesReference

092178
stoichiometry: 1.0
species: 326551
type: SpeciesReference

105822
stoichiometry: 1.0
species: 326793
type: SpeciesReference

327283
kinetic law: 082876
product: 082864
reactant: 082852
fast: false
reversible: true
name: v177 ErbB2 -> ErbB2 k6b kd6b
type: Reaction

093754
stoichiometry: 1.0
species: 326571
type: SpeciesReference

075289
stoichiometry: 1.0
species: 325938
type: SpeciesReference

102870
stoichiometry: 1.0
species: 326677
type: SpeciesReference

327117
kinetic law: 079056
product: 079044
reactant: 079031
reactant: 079019
fast: false
reversible: true
name: v90 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

329047
constant: true
value: 6.0
name: k23
type: Parameter

081598
stoichiometry: 1.0
species: 326118
type: SpeciesReference

328039
kinetic law: 100340
product: 100328
reactant: 100316
fast: false
reversible: true
name: v557 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

108796
stoichiometry: 1.0
species: 326627
type: SpeciesReference

091168
stoichiometry: 1.0
species: 326205
type: SpeciesReference

101627
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326189
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

329341
constant: true
value: 0.0
name: k113
type: Parameter

087554
stoichiometry: 1.0
species: 326541
type: SpeciesReference

106437
stoichiometry: 1.0
species: 326793
type: SpeciesReference

078262
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327287
kinetic law: 082949
product: 082936
reactant: 082924
fast: false
reversible: true
name: v179 (ErbB3:ErbB2)#P:GAP:Shc ->(ErbB3:ErbB2)#P:GAP:Shc k6b kd6b
type: Reaction

084866
stoichiometry: 1.0
species: 326529
type: SpeciesReference

326725
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)4
type: Species

076151
stoichiometry: 1.0
species: 325992
type: SpeciesReference

326431
notes: 2(EGF:ErbB1)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP
type: Species

102930
stoichiometry: 1.0
species: 326703
type: SpeciesReference

327447
kinetic law: 086628
product: 086616
reactant: 086604
reactant: 086592
fast: false
reversible: true
name: v260 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

327757
kinetic law: 093973
product: 093961
reactant: 093948
reactant: 093936
fast: false
reversible: true
name: v415 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
type: Reaction

102531
stoichiometry: 1.0
species: 326629
type: SpeciesReference

077019
stoichiometry: 1.0
species: 326062
type: SpeciesReference

108856
stoichiometry: 1.0
species: 326861
type: SpeciesReference

109543
stoichiometry: 1.0
species: 326875
type: SpeciesReference

327285
kinetic law: 082912
product: 082900
reactant: 082888
fast: false
reversible: true
name: v178 ErbB4 -> ErbB4 k6b kd6b
type: Reaction

095705
stoichiometry: 1.0
species: 326497
type: SpeciesReference

327115
kinetic law: 079007
product: 078995
reactant: 078983
reactant: 078971
fast: false
reversible: true
name: v89 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
type: Reaction

077925
stoichiometry: 1.0
species: 326056
type: SpeciesReference

099956
stoichiometry: 1.0
species: 326391
type: SpeciesReference

090712
stoichiometry: 1.0
species: 326415
type: SpeciesReference

099127
stoichiometry: 1.0
species: 326423
type: SpeciesReference

096006
stoichiometry: 1.0
species: 326525
type: SpeciesReference

329045
constant: true
value: 0.1
name: kd22
type: Parameter

113168
stoichiometry: 1.0
species: 326941
type: SpeciesReference

328223
kinetic law: 104204
product: 104192
reactant: 104180
reactant: 104168
fast: false
reversible: true
name: v653 RTK_Pase + 2(ErbB2)#P -> 2(ErbB2)#P:RTK_Pase k94 kd94
type: Reaction

328589
kinetic law: 113035
product: 113023
reactant: 113011
reactant: 112999
fast: false
reversible: true
name: v857 2(EGF:ErbB1_h:ATP) + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k122 kd122
type: Reaction

083636
stoichiometry: 1.0
species: 326431
type: SpeciesReference

095249
stoichiometry: 1.0
species: 326521
type: SpeciesReference

112479
stoichiometry: 1.0
species: 325980
type: SpeciesReference

110628
stoichiometry: 1.0
species: 325950
type: SpeciesReference

096932
stoichiometry: 1.0
species: 326108
type: SpeciesReference

327109
kinetic law: 078863
product: 078851
reactant: 078839
reactant: 078827
fast: false
reversible: true
name: v85 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

112366
stoichiometry: 1.0
species: 325922
type: SpeciesReference

107846
stoichiometry: 1.0
species: 326683
type: SpeciesReference

106798
stoichiometry: 1.0
species: 326807
type: SpeciesReference

109110
stoichiometry: 1.0
species: 326871
type: SpeciesReference

076753
stoichiometry: 1.0
species: 326038
type: SpeciesReference

095189
stoichiometry: 1.0
species: 326513
type: SpeciesReference

106834
stoichiometry: 1.0
species: 326691
type: SpeciesReference

328117
kinetic law: 101748
product: 101736
reactant: 101724
fast: false
reversible: true
name: v600 (EGF:ErbB1:ErbB2) -> R_degraded k62b kd60b
type: Reaction

328477
kinetic law: 110315
product: 110303
reactant: 110291
reactant: 110279
fast: false
reversible: true
name: v780 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118
type: Reaction

326219
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

326875
notes: (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
type: Species

329271
constant: true
value: 3.0E-7
name: Kinh2
type: Parameter

326441
notes: (ErbB3:ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Shc
type: Species

327457
kinetic law: 086868
product: 086856
reactant: 086844
reactant: 086832
fast: false
reversible: true
name: v265 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

327341
kinetic law: 084083
product: 084071
reactant: 084059
reactant: 084047
fast: false
reversible: true
name: v206 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8
type: Reaction

090796
stoichiometry: 1.0
species: 326541
type: SpeciesReference

326949
kinetic law: 074976
product: 074964
reactant: 074951
reactant: 074939
fast: false
reversible: true
name: v2 (ErbB2:ErbB3) + EGF -> (ErbB3:ErbB2)#P k1c kd1c
type: Reaction

099572
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326723
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)3
type: Species

325994
boundary condition: false
name: EGF:ErbB1:ErbB3:ATP
type: Species
initial amount: 0.0
constant: false
initial concentration: NaN
in compartment: 325908
has version: P01133
notes: EGF:ErbB1:ErbB3:ATP , cytoplasm
has part: P00533
has only substance units: true

079092
stoichiometry: 1.0
species: 326263
type: SpeciesReference

079804
stoichiometry: 1.0
species: 326317
type: SpeciesReference

328195
kinetic law: 103531
product: 103519
reactant: 103507
reactant: 103495
fast: false
reversible: true
name: v639 PIP3 + AKT -> PIP3:AKT k69 kd69
type: Reaction

107810
stoichiometry: 1.0
species: 326831
type: SpeciesReference

088638
stoichiometry: 1.0
species: 326152
type: SpeciesReference

328221
kinetic law: 104156
product: 104144
reactant: 104132
reactant: 104120
fast: false
reversible: true
name: v652 RTK_Pase + 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P:RTK_Pase k94 kd94
type: Reaction

098260
stoichiometry: 1.0
species: 326603
type: SpeciesReference

328587
kinetic law: 112987
product: 112975
reactant: 112963
reactant: 112951
fast: false
reversible: true
name: v856 EGF:ErbB1:Inh::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k122 kd122
type: Reaction

327107
kinetic law: 078815
product: 078803
reactant: 078791
reactant: 078779
fast: false
reversible: true
name: v84 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

327231
kinetic law: 081805
product: 081793
reactant: 081781
reactant: 081769
fast: false
reversible: true
name: v150 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
type: Reaction

098837
stoichiometry: 1.0
species: 326623
type: SpeciesReference

083564
stoichiometry: 1.0
species: 326471
type: SpeciesReference

098115
stoichiometry: 1.0
species: 326589
type: SpeciesReference

098789
stoichiometry: 1.0
species: 326629
type: SpeciesReference

110964
stoichiometry: 1.0
species: 326775
type: SpeciesReference

327281
kinetic law: 082840
product: 082828
reactant: 082816
fast: false
reversible: true
name: v176 ErbB3 -> ErbB3 k6b kd6b
type: Reaction

105521
stoichiometry: 1.0
species: 326771
type: SpeciesReference

328473
kinetic law: 110219
product: 110207
reactant: 110195
reactant: 110183
fast: false
reversible: true
name: v778 Pase9t + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)2:Gab1#P##:Pase9t k118 kd118
type: Reaction

082177
stoichiometry: 1.0
species: 326070
type: SpeciesReference

085205
stoichiometry: 1.0
species: 326521
type: SpeciesReference

327979
kinetic law: 099260
product: 099248
reactant: 099236
fast: false
reversible: true
name: v526 2(EGF:ErbB1)#P:GAP:Grb2 -> R_degraded k60 kd60
type: Reaction

326721
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)2
type: Species

106220
stoichiometry: 1.0
species: 326713
type: SpeciesReference

326217
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

328475
kinetic law: 110267
product: 110255
reactant: 110243
reactant: 110231
fast: false
reversible: true
name: v779 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118
type: Reaction

093032
stoichiometry: 1.0
species: 326413
type: SpeciesReference

328115
kinetic law: 101712
product: 101700
reactant: 101688
fast: false
reversible: true
name: v599 EGF -> EGF_degraded k61 kd61
type: Reaction

327343
kinetic law: 084132
product: 084119
reactant: 084107
reactant: 084095
fast: false
reversible: true
name: v207 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8
type: Reaction

329273
constant: true
value: 0.001
name: kd98
type: Parameter

326947
kinetic law: 074927
product: 074915
reactant: 074902
reactant: 074890
fast: false
reversible: true
name: v1 EGF + ErbB1:ATP -> EGF:ErbB1:ATP k1 kd1
type: Reaction

327455
kinetic law: 086820
product: 086808
reactant: 086796
reactant: 086784
fast: false
reversible: true
name: v264 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

097017
stoichiometry: 1.0
species: 326535
type: SpeciesReference

112711
stoichiometry: 1.0
species: 325926
type: SpeciesReference

326877
notes: AKT:P:P:Raf:P:Ser , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P:Raf:P:Ser
type: Species

094297
stoichiometry: 1.0
species: 326355
type: SpeciesReference

085990
stoichiometry: 1.0
species: 326421
type: SpeciesReference

106642
stoichiometry: 1.0
species: 326723
type: SpeciesReference

325992
notes: EGF:ErbB1:ErbB2:ATP , cytoplasm
boundary condition: false
initial concentration: NaN
type: Species
in compartment: 325908
initial amount: 0.0
constant: false
name: EGF:ErbB1:ErbB2:ATP
has part: P00533
has version: P01133
has only substance units: true

102494
stoichiometry: 1.0
species: 326673
type: SpeciesReference

111912
stoichiometry: 1.0
species: 325980
type: SpeciesReference

328197
kinetic law: 103580
product: 103568
reactant: 103555
reactant: 103543
fast: false
reversible: true
name: v640 PIP3 + AKT#P -> PIP3:AKT#P k69 kd69
type: Reaction

107990
stoichiometry: 1.0
species: 326695
type: SpeciesReference

082599
stoichiometry: 1.0
species: 326068
type: SpeciesReference

328031
kinetic law: 100196
product: 100184
reactant: 100172
fast: false
reversible: true
name: v553 (ErbB1:ErbB3)#P:GAP:Grb2 -> R_degraded k60b kd60
type: Reaction

111228
stoichiometry: 1.0
species: 326923
type: SpeciesReference

084204
stoichiometry: 1.0
species: 326517
type: SpeciesReference

078803
stoichiometry: 1.0
species: 326239
type: SpeciesReference

328199
kinetic law: 103628
product: 103616
reactant: 103604
reactant: 103592
fast: false
reversible: true
name: v641 PDK1 + PIP3:AKT#P -> PIP3:AKT#P:PDK1 k70 kd70
type: Reaction

088179
stoichiometry: 1.0
species: 326076
type: SpeciesReference

090300
stoichiometry: 1.0
species: 326319
type: SpeciesReference

104664
stoichiometry: 1.0
species: 326653
type: SpeciesReference

325922
boundary condition: false
notes: (ErbB4:ErbB2)#P , plasma membrane
has only substance units: true
initial amount: 0.0
initial concentration: NaN
has part: P04626
in compartment: 325898
has part: Q15303
constant: false
type: Species
name: (ErbB4:ErbB2)_P

328471
kinetic law: 110171
product: 110159
reactant: 110147
reactant: 110135
fast: false
reversible: true
name: v777 Pase9t + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1):Gab1#P##:Pase9t k118 kd118
type: Reaction

329277
constant: true
value: 0.113
name: Kinh4
type: Parameter

081745
stoichiometry: 1.0
species: 326106
type: SpeciesReference

096150
stoichiometry: 1.0
species: 326523
type: SpeciesReference

327453
kinetic law: 086772
product: 086760
reactant: 086748
reactant: 086736
fast: false
reversible: true
name: v263 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

087770
stoichiometry: 1.0
species: 326317
type: SpeciesReference

089469
stoichiometry: 1.0
species: 326367
type: SpeciesReference

326879
notes: AKT:P:P:Raf:P:Ser_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT:P:P:Raf:P:Ser_i
type: Species

326945
notes: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive
type: Species

327345
kinetic law: 084180
product: 084168
reactant: 084156
reactant: 084144
fast: false
reversible: true
name: v208 ErbB1:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
type: Reaction

326102
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
type: Species

091384
stoichiometry: 1.0
species: 326365
type: SpeciesReference

329275
constant: true
value: 33300.0
name: k98
type: Parameter

326215
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:cPP
type: Species

096404
stoichiometry: 1.0
species: 326457
type: SpeciesReference

102639
stoichiometry: 1.0
species: 326679
type: SpeciesReference

088578
stoichiometry: 1.0
species: 326201
type: SpeciesReference

327977
kinetic law: 099224
product: 099212
reactant: 099200
fast: false
reversible: true
name: v525 2(EGF:ErbB1)#P:GAP -> R_degraded k60 kd60
type: Reaction

101145
stoichiometry: 1.0
species: 326337
type: SpeciesReference

078538
stoichiometry: 1.0
species: 326217
type: SpeciesReference

325998
notes: ErbB2:ErbB2#P , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB2:ErbB2_P
type: Species

078875
stoichiometry: 1.0
species: 326245
type: SpeciesReference

108520
stoichiometry: 1.0
species: 326855
type: SpeciesReference

096090
stoichiometry: 1.0
species: 326481
type: SpeciesReference

099284
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327079
kinetic law: 078142
product: 078130
reactant: 078118
reactant: 078106
fast: false
reversible: true
name: v68 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

086014
stoichiometry: 1.0
species: 326539
type: SpeciesReference

093320
stoichiometry: 1.0
species: 326401
type: SpeciesReference

082755
stoichiometry: 1.0
species: 326407
type: SpeciesReference

325920
boundary condition: false
notes: ErbB2:ErbB4 , plasma membrane
has only substance units: true
initial concentration: NaN
initial amount: 0.0
has part: P04626
in compartment: 325898
has part: Q15303
name: ErbB2:ErbB4
type: Species
constant: false

111636
stoichiometry: 1.0
species: 325984
type: SpeciesReference

086664
stoichiometry: 1.0
species: 326120
type: SpeciesReference

086303
stoichiometry: 1.0
species: 326539
type: SpeciesReference

075337
stoichiometry: 1.0
species: 325942
type: SpeciesReference

329279
constant: true
value: 0.5
name: kd99
type: Parameter

092226
stoichiometry: 1.0
species: 326551
type: SpeciesReference

089108
stoichiometry: 1.0
species: 326337
type: SpeciesReference

100256
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326213
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2
type: Species

090640
stoichiometry: 1.0
species: 326411
type: SpeciesReference

328119
kinetic law: 101785
product: 101772
reactant: 101760
fast: false
reversible: true
name: v601 (EGF:ErbB1:ErbB3) -> R_degraded k62b kd60b
type: Reaction

326943
notes: 2(EGF:ErbB1_h:ATP)-FullActive , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1_h:ATP)-FullActive
type: Species

327347
kinetic law: 084228
product: 084216
reactant: 084204
reactant: 084192
fast: false
reversible: true
name: v209 ErbB3 + -> (HRG:ErbB3) k10b kd10
type: Reaction

326100
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
type: Species

095777
stoichiometry: 1.0
species: 326537
type: SpeciesReference

327451
kinetic law: 086724
product: 086712
reactant: 086700
reactant: 086688
fast: false
reversible: true
name: v262 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

327975
kinetic law: 099188
product: 099176
reactant: 099164
fast: false
reversible: true
name: v524 2(EGF:ErbB1:ATP) -> R_degraded k60 kd60
type: Reaction

081391
stoichiometry: 1.0
species: 326383
type: SpeciesReference

097971
stoichiometry: 1.0
species: 326601
type: SpeciesReference

102314
stoichiometry: 1.0
species: 326665
type: SpeciesReference

325996
initial amount: 0.0
has version: P01133
notes: EGF:ErbB1:ErbB4:ATP , cytoplasm
name: EGF:ErbB1:ErbB4:ATP
type: Species
has part: P00533
initial concentration: NaN
in compartment: 325908
has only substance units: true
constant: false
boundary condition: false

109158
stoichiometry: 1.0
species: 326873
type: SpeciesReference

098465
stoichiometry: 1.0
species: 326601
type: SpeciesReference

104024
stoichiometry: 1.0
species: 326755
type: SpeciesReference

080872
stoichiometry: 1.0
species: 326207
type: SpeciesReference

094923
stoichiometry: 1.0
species: 326359
type: SpeciesReference

326070
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
type: Species

091276
stoichiometry: 1.0
species: 326541
type: SpeciesReference

105979
stoichiometry: 1.0
species: 326006
type: SpeciesReference

077792
stoichiometry: 1.0
species: 326126
type: SpeciesReference

325926
has part: P00533
constant: false
notes: EGF:ErbB1:Inh , plasma membrane
type: Species
initial amount: 0.0
boundary condition: false
in compartment: 325898
initial concentration: NaN
has only substance units: true
name: EGF:ErbB1:Inh
has version: P01133

094573
stoichiometry: 1.0
species: 326577
type: SpeciesReference

111588
stoichiometry: 1.0
species: 325982
type: SpeciesReference

327561
kinetic law: 089378
product: 089365
reactant: 089351
reactant: 089339
fast: false
reversible: true
name: v317 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

327821
kinetic law: 095501
product: 095489
reactant: 095477
reactant: 095465
fast: false
reversible: true
name: v447 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

327237
kinetic law: 081949
product: 081937
reactant: 081925
reactant: 081913
fast: false
reversible: true
name: v153 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
type: Reaction

326593
notes: MEK:Raf#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK:Raf_P
type: Species

083913
stoichiometry: 1.0
species: 325922
type: SpeciesReference

095669
stoichiometry: 1.0
species: 326523
type: SpeciesReference

090928
stoichiometry: 1.0
species: 326108
type: SpeciesReference

086459
stoichiometry: 1.0
species: 326421
type: SpeciesReference

105677
stoichiometry: 1.0
species: 325946
type: SpeciesReference

328581
kinetic law: 112843
product: 112831
reactant: 112819
reactant: 112807
fast: false
reversible: true
name: v853 EGF:ErbB1_h:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh k2 kd2
type: Reaction

326517
notes: HRG , endosomes
in compartment: 325900
initial amount: 0.0
name: HRG
has only substance units: true
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is version of: Q02297
is version of: IPR018250
type: Species

074915
stoichiometry: 1.0
species: 325914
type: SpeciesReference

327973
kinetic law: 099152
product: 099139
reactant: 099127
fast: false
reversible: true
name: v523 ErbB1:ATP -> R_degraded k60 kd60
type: Reaction

112687
stoichiometry: 1.0
species: 326929
type: SpeciesReference

080764
stoichiometry: 1.0
species: 326357
type: SpeciesReference

107279
stoichiometry: 1.0
species: 326813
type: SpeciesReference

075446
stoichiometry: 1.0
species: 325952
type: SpeciesReference

326072
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2
type: Species

088928
stoichiometry: 1.0
species: 326335
type: SpeciesReference

102206
stoichiometry: 1.0
species: 326411
type: SpeciesReference

103327
stoichiometry: 1.0
species: 326723
type: SpeciesReference

325924
name: ErbB1:Inh
type: Species
constant: false
boundary condition: false
in compartment: 325898
initial amount: 0.0
initial concentration: NaN
has only substance units: true
notes: ErbB1:Inh , plasma membrane
has part: P00533

327239
kinetic law: 081997
product: 081985
reactant: 081973
reactant: 081961
fast: false
reversible: true
name: v155 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5
type: Reaction

084529
stoichiometry: 1.0
species: 326501
type: SpeciesReference

327609
kinetic law: 090579
product: 090566
reactant: 090554
reactant: 090542
fast: false
reversible: true
name: v341 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
type: Reaction

078646
stoichiometry: 1.0
species: 326056
type: SpeciesReference

075983
stoichiometry: 1.0
species: 325960
type: SpeciesReference

326369
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

328229
kinetic law: 104351
product: 104339
reactant: 104326
reactant: 104313
fast: false
reversible: true
name: v656 RTK_Pase + (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P:RTK_Pase k94 kd94
type: Reaction

100100
stoichiometry: 1.0
species: 326383
type: SpeciesReference

329121
constant: false
value: 0.79
name: kd48
type: Parameter

084710
stoichiometry: 1.0
species: 326497
type: SpeciesReference

087073
stoichiometry: 1.0
species: 326541
type: SpeciesReference

111564
stoichiometry: 1.0
species: 326463
type: SpeciesReference

078947
stoichiometry: 1.0
species: 326251
type: SpeciesReference

106196
stoichiometry: 1.0
species: 326793
type: SpeciesReference

326591
notes: (MEK:Raf#P)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (MEK:Raf_P)_i
type: Species

076971
stoichiometry: 1.0
species: 326058
type: SpeciesReference

103988
stoichiometry: 1.0
species: 326707
type: SpeciesReference

098356
stoichiometry: 1.0
species: 326613
type: SpeciesReference

326515
in compartment: 325900
notes: EGF , endosomes
constant: false
initial amount: 0.0
is: SBO:0000252
initial concentration: NaN
is version of: P01133
type: Species
has only substance units: true
is version of: GO:0005154
name: EGF
boundary condition: false

086556
stoichiometry: 1.0
species: 326100
type: SpeciesReference

099848
stoichiometry: 1.0
species: 326397
type: SpeciesReference

327971
kinetic law: 099115
product: 099103
reactant: 099091
reactant: 099079
fast: false
reversible: true
name: v522 Pase3 + (ERK#P)_i -> (ERK#P:Pase3)_i k58 kd58
type: Reaction

077635
stoichiometry: 1.0
species: 326056
type: SpeciesReference

076862
stoichiometry: 1.0
species: 325980
type: SpeciesReference

096620
stoichiometry: 1.0
species: 326513
type: SpeciesReference

111708
stoichiometry: 1.0
species: 326427
type: SpeciesReference

092431
stoichiometry: 1.0
species: 326513
type: SpeciesReference

326597
notes: MEK#P:Raf#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_P:Raf_P
type: Species

327565
kinetic law: 089482
product: 089469
reactant: 089456
reactant: 089443
fast: false
reversible: true
name: v319 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

327233
kinetic law: 081853
product: 081841
reactant: 081829
reactant: 081817
fast: false
reversible: true
name: v151 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
type: Reaction

097537
stoichiometry: 1.0
species: 326565
type: SpeciesReference

328585
kinetic law: 112939
product: 112927
reactant: 112915
reactant: 112903
fast: false
reversible: true
name: v855 EGF:ErbB1:ATP::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k122 kd122
type: Reaction

328227
kinetic law: 104301
product: 104289
reactant: 104277
reactant: 104264
fast: false
reversible: true
name: v655 RTK_Pase + (ErbB4:ErbB2)#P -> (ErbB2:ErbB4)#P:RTK_Pase k94 kd94
type: Reaction

327825
kinetic law: 095597
product: 095585
reactant: 095573
reactant: 095561
fast: false
reversible: true
name: v449 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
type: Reaction

095297
stoichiometry: 1.0
species: 326551
type: SpeciesReference

082973
stoichiometry: 1.0
species: 326447
type: SpeciesReference

328191
kinetic law: 103435
product: 103423
reactant: 103411
reactant: 103399
fast: false
reversible: true
name: v637 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k68 kd68b
type: Reaction

327171
kinetic law: 080356
product: 080344
reactant: 080332
reactant: 080320
fast: false
reversible: true
name: v117 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b
type: Reaction

325990
has part: P00533
initial concentration: NaN
has version: P01133
initial amount: 0.0
has only substance units: true
in compartment: 325908
boundary condition: false
notes: 2(EGF:ErbB1:ATP)-FullActive , cytoplasm
name: 2(EGF:ErbB1:ATP)-FullActive
type: Species
constant: false

096824
stoichiometry: 1.0
species: 326527
type: SpeciesReference

107123
stoichiometry: 1.0
species: 326002
type: SpeciesReference

110736
stoichiometry: 1.0
species: 326030
type: SpeciesReference

327679
kinetic law: 092262
product: 092250
reactant: 092238
reactant: 092226
fast: false
reversible: true
name: v376 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b
type: Reaction

089192
stoichiometry: 1.0
species: 326549
type: SpeciesReference

326871
notes: 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
type: Species

328113
kinetic law: 101675
product: 101663
reactant: 101651
fast: false
reversible: true
name: v598 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
type: Reaction

100545
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326513
notes: (ErbB4:ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP
type: Species

097501
stoichiometry: 1.0
species: 326579
type: SpeciesReference

087337
stoichiometry: 1.0
species: 326261
type: SpeciesReference

107327
stoichiometry: 1.0
species: 326815
type: SpeciesReference

102386
stoichiometry: 1.0
species: 326627
type: SpeciesReference

081137
stoichiometry: 1.0
species: 326309
type: SpeciesReference

326595
notes: MEK#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_P
type: Species

079321
stoichiometry: 1.0
species: 326056
type: SpeciesReference

098946
stoichiometry: 1.0
species: 326631
type: SpeciesReference

327235
kinetic law: 081901
product: 081889
reactant: 081877
reactant: 081865
fast: false
reversible: true
name: v152 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
type: Reaction

327563
kinetic law: 089430
product: 089417
reactant: 089404
reactant: 089391
fast: false
reversible: true
name: v318 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

079888
stoichiometry: 1.0
species: 326309
type: SpeciesReference

325928
name: (EGF:ErbB1:ATP::EGF:ErbB1:Inh)
has part: P00533
boundary condition: false
initial concentration: NaN
has only substance units: true
initial amount: 0.0
has part: CHEBI:15422
constant: false
type: Species
notes: (EGF:ErbB1:ATP::EGF:ErbB1:Inh) , plasma membrane
in compartment: 325898
has version: P01133

327823
kinetic law: 095549
product: 095537
reactant: 095525
reactant: 095513
fast: false
reversible: true
name: v448 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37
type: Reaction

328225
kinetic law: 104252
product: 104240
reactant: 104228
reactant: 104216
fast: false
reversible: true
name: v654 RTK_Pase + (ErbB3:ErbB2)#P -> (ErbB2:ErbB3)#P:RTK_Pase k94 kd94
type: Reaction

093188
stoichiometry: 1.0
species: 326108
type: SpeciesReference

083998
stoichiometry: 1.0
species: 326493
type: SpeciesReference

081937
stoichiometry: 1.0
species: 326090
type: SpeciesReference

328583
kinetic law: 112891
product: 112879
reactant: 112867
reactant: 112855
fast: false
reversible: true
name: v854 EGF:ErbB1_h:Inh + EGF:ErbB1:Inh -> EGF:ErbB1_h:Inh::EGF:ErbB1:Inh k2 kd2
type: Reaction

328193
kinetic law: 103483
product: 103471
reactant: 103459
reactant: 103447
fast: false
reversible: true
name: v638 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k68 kd68b
type: Reaction

092769
stoichiometry: 1.0
species: 326527
type: SpeciesReference

093608
stoichiometry: 1.0
species: 326341
type: SpeciesReference

094851
stoichiometry: 1.0
species: 326497
type: SpeciesReference

081672
stoichiometry: 1.0
species: 326309
type: SpeciesReference

098897
stoichiometry: 1.0
species: 326631
type: SpeciesReference

085881
stoichiometry: 1.0
species: 326229
type: SpeciesReference

327173
kinetic law: 080404
product: 080392
reactant: 080380
reactant: 080368
fast: false
reversible: true
name: v118 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b
type: Reaction

327677
kinetic law: 092214
product: 092202
reactant: 092190
reactant: 092178
fast: false
reversible: true
name: v375 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b
type: Reaction

087842
stoichiometry: 1.0
species: 326545
type: SpeciesReference

110856
stoichiometry: 1.0
species: 326423
type: SpeciesReference

326511
notes: (ErbB3:ErbB2)#P:GAP , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP
type: Species

086399
stoichiometry: 1.0
species: 326541
type: SpeciesReference

086231
stoichiometry: 1.0
species: 326363
type: SpeciesReference

099632
stoichiometry: 1.0
species: 325950
type: SpeciesReference

328111
kinetic law: 101639
product: 101627
reactant: 101615
fast: false
reversible: true
name: v597 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
type: Reaction

326873
notes: (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
type: Species

082069
stoichiometry: 1.0
species: 326411
type: SpeciesReference

080080
stoichiometry: 1.0
species: 326309
type: SpeciesReference

328479
kinetic law: 110363
product: 110351
reactant: 110339
reactant: 110327
fast: false
reversible: true
name: v781 Pase9t + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k118 kd118
type: Reaction

087265
stoichiometry: 1.0
species: 326541
type: SpeciesReference

111852
stoichiometry: 1.0
species: 326473
type: SpeciesReference

102170
stoichiometry: 1.0
species: 326659
type: SpeciesReference

328939
constant: true
units: item
value: 695000.0
name: total ERK
type: Parameter

326068
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)
type: Species

094333
stoichiometry: 1.0
species: 326575
type: SpeciesReference

106558
stoichiometry: 1.0
species: 326721
type: SpeciesReference

327697
kinetic law: 092637
product: 092625
reactant: 092613
fast: false
reversible: true
name: v385 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

327741
kinetic law: 093584
product: 093572
reactant: 093560
reactant: 093548
fast: false
reversible: true
name: v407 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

077429
stoichiometry: 1.0
species: 326096
type: SpeciesReference

327019
kinetic law: 076693
product: 076681
reactant: 076669
reactant: 076657
fast: false
reversible: true
name: v37 (HRG:ErbB3:ErbB1) + ATP -> (HRG:ErbB3:ErbB1):ATP k122 kd122
type: Reaction

326663
notes: (ERK#P#P):Sos , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: (ERK_PP):Sos
type: Species

097308
stoichiometry: 1.0
species: 326457
type: SpeciesReference

097453
stoichiometry: 1.0
species: 326573
type: SpeciesReference

109423
stoichiometry: 1.0
species: 326543
type: SpeciesReference

096692
stoichiometry: 1.0
species: 326575
type: SpeciesReference

329117
constant: true
value: 0.0
name: k47
type: Parameter

326385
notes: (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

087698
stoichiometry: 1.0
species: 326543
type: SpeciesReference

326599
notes: MEK#P#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MEK_PP
type: Species

327189
kinetic law: 080788
product: 080776
reactant: 080764
reactant: 080752
fast: false
reversible: true
name: v127 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
type: Reaction

327543
kinetic law: 088940
product: 088928
reactant: 088916
reactant: 088904
fast: false
reversible: true
name: v308 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

076367
stoichiometry: 1.0
species: 326006
type: SpeciesReference

327815
kinetic law: 095357
product: 095345
reactant: 095333
reactant: 095321
fast: false
reversible: true
name: v444 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37
type: Reaction

089120
stoichiometry: 1.0
species: 326329
type: SpeciesReference

092996
stoichiometry: 1.0
species: 326076
type: SpeciesReference

091048
stoichiometry: 1.0
species: 326385
type: SpeciesReference

083299
stoichiometry: 1.0
species: 326477
type: SpeciesReference

102918
stoichiometry: 1.0
species: 326677
type: SpeciesReference

092010
stoichiometry: 1.0
species: 326557
type: SpeciesReference

327743
kinetic law: 093632
product: 093620
reactant: 093608
reactant: 093596
fast: false
reversible: true
name: v408 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
type: Reaction

327699
kinetic law: 092673
product: 092661
reactant: 092649
fast: false
reversible: true
name: v386 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

326066
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
type: Species

326661
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(ERK_PP)
type: Species

081451
stoichiometry: 1.0
species: 326130
type: SpeciesReference

113071
stoichiometry: 1.0
species: 326945
type: SpeciesReference

108508
stoichiometry: 1.0
species: 326627
type: SpeciesReference

093936
stoichiometry: 1.0
species: 326501
type: SpeciesReference

080632
stoichiometry: 1.0
species: 326227
type: SpeciesReference

109964
stoichiometry: 1.0
species: 326893
type: SpeciesReference

108388
stoichiometry: 1.0
species: 326839
type: SpeciesReference

107556
stoichiometry: 1.0
species: 326679
type: SpeciesReference

105255
stoichiometry: 1.0
species: 326465
type: SpeciesReference

329115
constant: true
value: 0.8
name: kd47
type: Parameter

080572
stoichiometry: 1.0
species: 326349
type: SpeciesReference

327545
kinetic law: 088988
product: 088976
reactant: 088964
reactant: 088952
fast: false
reversible: true
name: v309 Ras:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

111144
stoichiometry: 1.0
species: 325910
type: SpeciesReference

327187
kinetic law: 080740
product: 080728
reactant: 080716
reactant: 080704
fast: false
reversible: true
name: v126 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
type: Reaction

326387
notes: (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

088444
stoichiometry: 1.0
species: 326393
type: SpeciesReference

078598
stoichiometry: 1.0
species: 326056
type: SpeciesReference

089351
stoichiometry: 1.0
species: 326547
type: SpeciesReference

327817
kinetic law: 095405
product: 095393
reactant: 095381
reactant: 095369
fast: false
reversible: true
name: v445 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
type: Reaction

085386
stoichiometry: 1.0
species: 326521
type: SpeciesReference

101989
stoichiometry: 1.0
species: 326641
type: SpeciesReference

101049
stoichiometry: 1.0
species: 326641
type: SpeciesReference

078418
stoichiometry: 1.0
species: 326207
type: SpeciesReference

081378
stoichiometry: 1.0
species: 326309
type: SpeciesReference

076439
stoichiometry: 1.0
species: 326012
type: SpeciesReference

108652
stoichiometry: 1.0
species: 326629
type: SpeciesReference

326507
notes: (ErbB3:ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP
type: Species

085302
stoichiometry: 1.0
species: 326449
type: SpeciesReference

327015
kinetic law: 076595
product: 076583
reactant: 076571
reactant: 076559
fast: false
reversible: true
name: v35 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

110135
stoichiometry: 1.0
species: 326885
type: SpeciesReference

327693
kinetic law: 092564
product: 092551
reactant: 092539
fast: false
reversible: true
name: v383 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

085978
stoichiometry: 1.0
species: 326419
type: SpeciesReference

099344
stoichiometry: 1.0
species: 326415
type: SpeciesReference

326667
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos_P
type: Species

111780
stoichiometry: 1.0
species: 325994
type: SpeciesReference

076583
stoichiometry: 1.0
species: 326024
type: SpeciesReference

075806
stoichiometry: 1.0
species: 325974
type: SpeciesReference

329113
constant: true
value: 0.0
name: k45
type: Parameter

085651
stoichiometry: 1.0
species: 326323
type: SpeciesReference

081041
stoichiometry: 1.0
species: 326309
type: SpeciesReference

093548
stoichiometry: 1.0
species: 326539
type: SpeciesReference

101905
stoichiometry: 1.0
species: 326046
type: SpeciesReference

092539
stoichiometry: 1.0
species: 326445
type: SpeciesReference

327547
kinetic law: 089036
product: 089024
reactant: 089012
reactant: 089000
fast: false
reversible: true
name: v310 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
type: Reaction

327219
kinetic law: 081513
product: 081500
reactant: 081488
reactant: 081476
fast: false
reversible: true
name: v144 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

090940
stoichiometry: 1.0
species: 326541
type: SpeciesReference

089574
stoichiometry: 1.0
species: 326068
type: SpeciesReference

091962
stoichiometry: 1.0
species: 326555
type: SpeciesReference

087470
stoichiometry: 1.0
species: 326325
type: SpeciesReference

086928
stoichiometry: 1.0
species: 326541
type: SpeciesReference

076511
stoichiometry: 1.0
species: 326018
type: SpeciesReference

092395
stoichiometry: 1.0
species: 326445
type: SpeciesReference

326389
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
type: Species

112879
stoichiometry: 1.0
species: 326937
type: SpeciesReference

329337
notes: %AKT aktiviert Ras
constant: true
value: 0.0047067
name: k112
type: Parameter

084481
stoichiometry: 1.0
species: 326439
type: SpeciesReference

327691
kinetic law: 092527
product: 092515
reactant: 092503
fast: false
reversible: true
name: v382 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

326064
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)
type: Species

105183
stoichiometry: 1.0
species: 326771
type: SpeciesReference

097162
stoichiometry: 1.0
species: 326491
type: SpeciesReference

095862
stoichiometry: 1.0
species: 326525
type: SpeciesReference

327819
kinetic law: 095453
product: 095441
reactant: 095429
reactant: 095417
fast: false
reversible: true
name: v446 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37
type: Reaction

104580
stoichiometry: 1.0
species: 326763
type: SpeciesReference

076223
stoichiometry: 1.0
species: 325948
type: SpeciesReference

327017
kinetic law: 076644
product: 076631
reactant: 076619
reactant: 076607
fast: false
reversible: true
name: v36 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

096716
stoichiometry: 1.0
species: 326577
type: SpeciesReference

326509
notes: (ErbB4:ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP
type: Species

088711
stoichiometry: 1.0
species: 326363
type: SpeciesReference

326665
notes: ((ERK#P#P):Sos)_i , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: ((ERK_PP):Sos)_i
type: Species

111024
stoichiometry: 1.0
species: 326913
type: SpeciesReference

110111
stoichiometry: 1.0
species: 326899
type: SpeciesReference

327695
kinetic law: 092601
product: 092589
reactant: 092576
fast: false
reversible: true
name: v384 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

075205
stoichiometry: 1.0
species: 325932
type: SpeciesReference

087614
stoichiometry: 1.0
species: 326285
type: SpeciesReference

091866
stoichiometry: 1.0
species: 326435
type: SpeciesReference

099428
stoichiometry: 1.0
species: 326641
type: SpeciesReference

093803
stoichiometry: 1.0
species: 326573
type: SpeciesReference

086760
stoichiometry: 1.0
species: 326391
type: SpeciesReference

094634
stoichiometry: 1.0
species: 326421
type: SpeciesReference

327217
kinetic law: 081463
product: 081451
reactant: 081439
reactant: 081427
fast: false
reversible: true
name: v143 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

327121
kinetic law: 079152
product: 079140
reactant: 079128
reactant: 079116
fast: false
reversible: true
name: v92 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

327549
kinetic law: 089084
product: 089072
reactant: 089060
reactant: 089048
fast: false
reversible: true
name: v311 Ras_activated:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

329051
constant: true
value: 0.55
name: kd24
type: Parameter

100316
stoichiometry: 1.0
species: 326371
type: SpeciesReference

079900
stoichiometry: 1.0
species: 326321
type: SpeciesReference

329111
constant: true
value: 1.9
name: kd45
type: Parameter

106111
stoichiometry: 1.0
species: 326801
type: SpeciesReference

326062
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos:cPP
type: Species

103880
stoichiometry: 1.0
species: 326731
type: SpeciesReference

329339
constant: true
value: 0.1
name: kd112
type: Parameter

092913
stoichiometry: 1.0
species: 326535
type: SpeciesReference

103555
stoichiometry: 1.0
species: 326735
type: SpeciesReference

098561
stoichiometry: 1.0
species: 326601
type: SpeciesReference

100977
stoichiometry: 1.0
species: 326641
type: SpeciesReference

104228
stoichiometry: 1.0
species: 326477
type: SpeciesReference

103122
stoichiometry: 1.0
species: 326689
type: SpeciesReference

102050
stoichiometry: 1.0
species: 326627
type: SpeciesReference

327061
kinetic law: 077707
product: 077695
reactant: 077683
reactant: 077671
fast: false
reversible: true
name: v59 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

109759
stoichiometry: 1.0
species: 326631
type: SpeciesReference

325988
in compartment: 325908
boundary condition: false
name: 2(EGF:ErbB1):ATP
has part: P00533
type: Species
initial concentration: NaN
constant: false
initial amount: 0.0
notes: 2(EGF:ErbB1):ATP , cytoplasm
has only substance units: true
has version: P01133

093476
stoichiometry: 1.0
species: 326253
type: SpeciesReference

097247
stoichiometry: 1.0
species: 326577
type: SpeciesReference

328023
kinetic law: 100052
product: 100040
reactant: 100028
fast: false
reversible: true
name: v549 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

112516
stoichiometry: 1.0
species: 326479
type: SpeciesReference

080200
stoichiometry: 1.0
species: 326263
type: SpeciesReference

326233
notes: 2(ErbB2)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos
type: Species

085869
stoichiometry: 1.0
species: 326539
type: SpeciesReference

327439
kinetic law: 086435
product: 086423
reactant: 086411
reactant: 086399
fast: false
reversible: true
name: v256 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

326447
notes: (ErbB4:ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB4:ErbB2)_P:GAP:Shc
type: Species

327327
kinetic law: 083745
product: 083733
reactant: 083721
reactant: 083709
fast: false
reversible: true
name: v199 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8 kd8
type: Reaction

326951
kinetic law: 075024
product: 075012
reactant: 075000
reactant: 074988
fast: false
reversible: true
name: v3 ErbB2:ErbB4 + EGF -> (ErbB4:ErbB2)#P k1d kd1d
type: Reaction

327749
kinetic law: 093778
product: 093766
reactant: 093754
reactant: 093742
fast: false
reversible: true
name: v411 (Ras_activated:GTP)_i + (Raf#P)_i -> (Raf:Ras:GTP)_i k29 kd29
type: Reaction

327011
kinetic law: 076499
product: 076487
reactant: 076475
reactant: 076463
fast: false
reversible: true
name: v33 2(ErbB2)#P:GAP:Grb2:Gab1 + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

079984
stoichiometry: 1.0
species: 326309
type: SpeciesReference

104240
stoichiometry: 1.0
species: 326765
type: SpeciesReference

085410
stoichiometry: 1.0
species: 326249
type: SpeciesReference

105473
stoichiometry: 1.0
species: 326771
type: SpeciesReference

095573
stoichiometry: 1.0
species: 326523
type: SpeciesReference

082394
stoichiometry: 1.0
species: 326423
type: SpeciesReference

329333
constant: true
value: 6.57
name: kd111
type: Parameter

079309
stoichiometry: 1.0
species: 326281
type: SpeciesReference

104700
stoichiometry: 1.0
species: 326771
type: SpeciesReference

091758
stoichiometry: 1.0
species: 326541
type: SpeciesReference

328021
kinetic law: 100016
product: 100004
reactant: 099992
fast: false
reversible: true
name: v548 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
type: Reaction

110532
stoichiometry: 1.0
species: 326901
type: SpeciesReference

079285
stoichiometry: 1.0
species: 326279
type: SpeciesReference

089600
stoichiometry: 1.0
species: 326076
type: SpeciesReference

088227
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327123
kinetic law: 079201
product: 079189
reactant: 079176
reactant: 079164
fast: false
reversible: true
name: v93 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

329053
constant: true
value: 1.67E-5
name: k25
type: Parameter

107762
stoichiometry: 1.0
species: 326829
type: SpeciesReference

088868
stoichiometry: 1.0
species: 326277
type: SpeciesReference

329057
constant: true
value: 5.0E-6
name: k28
type: Parameter

327063
kinetic law: 077756
product: 077744
reactant: 077731
reactant: 077719
fast: false
reversible: true
name: v60 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

103278
stoichiometry: 1.0
species: 326721
type: SpeciesReference

328025
kinetic law: 100088
product: 100076
reactant: 100064
fast: false
reversible: true
name: v550 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

077357
stoichiometry: 1.0
species: 326090
type: SpeciesReference

095465
stoichiometry: 1.0
species: 326431
type: SpeciesReference

083143
stoichiometry: 1.0
species: 326461
type: SpeciesReference

106003
stoichiometry: 1.0
species: 326144
type: SpeciesReference

326669
notes: 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:(Sos_P)
type: Species

326235
notes: 2(ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:Sos:cPP
type: Species

326953
kinetic law: 075073
product: 075061
reactant: 075049
reactant: 075036
fast: false
reversible: true
name: v4 EGF + ErbB1:Inh -> EGF:ErbB1:Inh k1 kd1
type: Reaction

327325
kinetic law: 083697
product: 083685
reactant: 083673
reactant: 083661
fast: false
reversible: true
name: v198 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8
type: Reaction

098031
stoichiometry: 1.0
species: 326603
type: SpeciesReference

326449
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB3:ErbB2)_P:GAP:(Shc_P)
type: Species

327013
kinetic law: 076547
product: 076535
reactant: 076523
reactant: 076511
fast: false
reversible: true
name: v34 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
type: Reaction

080152
stoichiometry: 1.0
species: 326267
type: SpeciesReference

083781
stoichiometry: 1.0
species: 326503
type: SpeciesReference

076007
stoichiometry: 1.0
species: 325986
type: SpeciesReference

100868
stoichiometry: 1.0
species: 326641
type: SpeciesReference

104797
stoichiometry: 1.0
species: 325938
type: SpeciesReference

329335
constant: true
value: 0.0
name: k111
type: Parameter

093899
stoichiometry: 1.0
species: 326575
type: SpeciesReference

108712
stoichiometry: 1.0
species: 326859
type: SpeciesReference

103664
stoichiometry: 1.0
species: 326743
type: SpeciesReference

075545
stoichiometry: 1.0
species: 325960
type: SpeciesReference

329269
constant: false
value: 0.001
name: kd97c
type: Parameter

110472
stoichiometry: 1.0
species: 326901
type: SpeciesReference

086712
stoichiometry: 1.0
species: 326393
type: SpeciesReference

078154
stoichiometry: 1.0
species: 326156
type: SpeciesReference

329055
constant: true
value: 0.0214
name: kd25
type: Parameter

327125
kinetic law: 079249
product: 079237
reactant: 079225
reactant: 079213
fast: false
reversible: true
name: v94 (ErbB3:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k4b kd4
type: Reaction

328027
kinetic law: 100124
product: 100112
reactant: 100100
fast: false
reversible: true
name: v551 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
type: Reaction

326381
notes: (ErbB1:ErbB2)#P:GAP:Grb2 , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB2)_P:GAP:Grb2
type: Species

090035
stoichiometry: 1.0
species: 326383
type: SpeciesReference

329059
constant: true
value: 0.0053
name: kd28
type: Parameter

109206
stoichiometry: 1.0
species: 326875
type: SpeciesReference

327745
kinetic law: 093681
product: 093669
reactant: 093657
reactant: 093644
fast: false
reversible: true
name: v409 Ras:GTP + Raf -> Raf:Ras:GTP k28 kd28
type: Reaction

075885
stoichiometry: 1.0
species: 325952
type: SpeciesReference

101579
stoichiometry: 1.0
species: 326315
type: SpeciesReference

326443
notes: (ErbB3:ErbB2)#P:GAP:Shc , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:Shc
type: Species

104917
stoichiometry: 1.0
species: 325976
type: SpeciesReference

326737
notes: PIP3:AKT#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT_P
type: Species

102942
stoichiometry: 1.0
species: 326705
type: SpeciesReference

078274
stoichiometry: 1.0
species: 326195
type: SpeciesReference

327299
kinetic law: 083167
product: 083155
reactant: 083143
fast: false
reversible: true
name: v185 (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P k7 kd7
type: Reaction

327435
kinetic law: 086339
product: 086327
reactant: 086315
reactant: 086303
fast: false
reversible: true
name: v254 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17
type: Reaction

106449
stoichiometry: 1.0
species: 326701
type: SpeciesReference

084878
stoichiometry: 1.0
species: 326092
type: SpeciesReference

094707
stoichiometry: 1.0
species: 326503
type: SpeciesReference

075910
stoichiometry: 1.0
species: 325982
type: SpeciesReference

108868
stoichiometry: 1.0
species: 326847
type: SpeciesReference

109531
stoichiometry: 1.0
species: 326817
type: SpeciesReference

077937
stoichiometry: 1.0
species: 326138
type: SpeciesReference

327127
kinetic law: 079297
product: 079285
reactant: 079273
reactant: 079261
fast: false
reversible: true
name: v95 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
type: Reaction

099139
stoichiometry: 1.0
species: 326641
type: SpeciesReference

076669
stoichiometry: 1.0
species: 325980
type: SpeciesReference

109855
stoichiometry: 1.0
species: 326851
type: SpeciesReference

326383
notes: (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

329119
constant: false
value: 2.37E-5
name: k48
type: Parameter

328029
kinetic law: 100160
product: 100148
reactant: 100136
fast: false
reversible: true
name: v552 (ErbB1:ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60
type: Reaction

085494
stoichiometry: 1.0
species: 326521
type: SpeciesReference

100748
stoichiometry: 1.0
species: 326353
type: SpeciesReference

088336
stoichiometry: 1.0
species: 326543
type: SpeciesReference

088784
stoichiometry: 1.0
species: 326373
type: SpeciesReference

099079
stoichiometry: 1.0
species: 326631
type: SpeciesReference

327329
kinetic law: 083793
product: 083781
reactant: 083769
reactant: 083757
fast: false
reversible: true
name: v200 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
type: Reaction

327437
kinetic law: 086387
product: 086375
reactant: 086363
reactant: 086351
fast: false
reversible: true
name: v255 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

101833
stoichiometry: 1.0
species: 326647
type: SpeciesReference

327747
kinetic law: 093729
product: 093717
reactant: 093705
reactant: 093693
fast: false
reversible: true
name: v410 (Ras:GTP)_i + Raf -> (Raf:Ras:GTP)_i k28 kd28
type: Reaction

098187
stoichiometry: 1.0
species: 326611
type: SpeciesReference

327297
kinetic law: 083130
product: 083118
reactant: 083106
fast: false
reversible: true
name: v184 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k6b kd6b
type: Reaction

104508
stoichiometry: 1.0
species: 326755
type: SpeciesReference

329331
constant: true
value: 0.1
name: kd110
type: Parameter

089012
stoichiometry: 1.0
species: 326337
type: SpeciesReference

112157
stoichiometry: 1.0
species: 326703
type: SpeciesReference

326231
notes: 2(ErbB2)#P:GAP:Grb2:cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2:cPP
type: Species

326739
has only substance units: true
initial amount: 3.00416E8
name: PDK1
in compartment: 325908
type: Species
boundary condition: false
is version of: O15530
initial concentration: NaN
notes: PDK1 , cytoplasm
constant: false

326445
notes: (ErbB4:ErbB2)#P:GAP:Shc , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB4:ErbB2)_P:GAP:Shc
type: Species

084156
stoichiometry: 1.0
species: 326515
type: SpeciesReference

108278
stoichiometry: 1.0
species: 326849
type: SpeciesReference

095681
stoichiometry: 1.0
species: 326533
type: SpeciesReference

327295
kinetic law: 083094
product: 083082
reactant: 083069
fast: false
reversible: true
name: v183 ErbB4:Inh -> ErbB4:Inh k6b kd6b
type: Reaction

093766
stoichiometry: 1.0
species: 326569
type: SpeciesReference

105810
stoichiometry: 1.0
species: 326797
type: SpeciesReference

096355
stoichiometry: 1.0
species: 326451
type: SpeciesReference

089704
stoichiometry: 1.0
species: 326549
type: SpeciesReference

075779
stoichiometry: 1.0
species: 325914
type: SpeciesReference

102882
stoichiometry: 1.0
species: 326699
type: SpeciesReference

111096
stoichiometry: 1.0
species: 326913
type: SpeciesReference

327129
kinetic law: 079345
product: 079333
reactant: 079321
reactant: 079309
fast: false
reversible: true
name: v96 (ErbB4:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k4b kd4
type: Reaction

075277
stoichiometry: 1.0
species: 325914
type: SpeciesReference

094225
stoichiometry: 1.0
species: 326481
type: SpeciesReference

074866
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

327119
kinetic law: 079104
product: 079092
reactant: 079080
reactant: 079068
fast: false
reversible: true
name: v91 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
type: Reaction

083576
stoichiometry: 1.0
species: 326493
type: SpeciesReference

083853
stoichiometry: 1.0
species: 326493
type: SpeciesReference

089096
stoichiometry: 1.0
species: 326549
type: SpeciesReference

328233
kinetic law: 104447
product: 104435
reactant: 104423
reactant: 104411
fast: false
reversible: true
name: v658 RTK_Pase + (EGF:ErbB1:ErbB3) -> (ErbB1:ErbB3)#P:RTK_Pase k95 kd95
type: Reaction

328575
kinetic law: 112699
product: 112687
reactant: 112674
reactant: 112662
fast: false
reversible: true
name: v850 EGF:ErbB1:ATP + EGF:ErbB1_h:ATP -> EGF:ErbB1:ATP::EGF:ErbB1_h:ATP k2 kd2
type: Reaction

328461
kinetic law: 109928
product: 109916
reactant: 109903
reactant: 109891
fast: false
reversible: true
name: v772 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117
type: Reaction

095946
stoichiometry: 1.0
species: 326495
type: SpeciesReference

082165
stoichiometry: 1.0
species: 326415
type: SpeciesReference

110952
stoichiometry: 1.0
species: 326909
type: SpeciesReference

105533
stoichiometry: 1.0
species: 326781
type: SpeciesReference

327293
kinetic law: 083057
product: 083045
reactant: 083033
fast: false
reversible: true
name: v182 ErbB2:Inh -> ErbB2:Inh k6b kd6b
type: Reaction

326807
notes: (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2
type: Species

094997
stoichiometry: 1.0
species: 326483
type: SpeciesReference

326733
notes: PIP3:AKT , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: PIP3:AKT
type: Species

326959
kinetic law: 075217
product: 075205
reactant: 075193
reactant: 075181
fast: false
reversible: true
name: v7 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP)) k2 kd2
type: Reaction

326451
notes: (ErbB3:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: (ErbB3:ErbB2)_P:GAP:(Shc_P)
type: Species

327331
kinetic law: 083841
product: 083829
reactant: 083817
reactant: 083805
fast: false
reversible: true
name: v201 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
type: Reaction

327443
kinetic law: 086532
product: 086520
reactant: 086508
reactant: 086496
fast: false
reversible: true
name: v258 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

097029
stoichiometry: 1.0
species: 326397
type: SpeciesReference

326889
notes: 2(ErbB2)2:Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)2:Gab1_P#:Pase9t
type: Species

112723
stoichiometry: 1.0
species: 326921
type: SpeciesReference

329261
constant: false
value: 1000000.0
name: k97
type: Parameter

327967
kinetic law: 099018
product: 099006
reactant: 098994
reactant: 098982
fast: false
reversible: true
name: v520 ERK + Pase3 -> (ERK#P:Pase3)_i k57 kd57
type: Reaction

328463
kinetic law: 109976
product: 109964
reactant: 109952
reactant: 109940
fast: false
reversible: true
name: v773 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117
type: Reaction

100184
stoichiometry: 1.0
species: 326641
type: SpeciesReference

093044
stoichiometry: 1.0
species: 326411
type: SpeciesReference

328127
kinetic law: 101929
product: 101917
reactant: 101905
fast: false
reversible: true
name: v605 (HRG:ErbB3):ErbB2) -> R_degraded k62b kd60b
type: Reaction

326229
notes: 2(ErbB2)#P:GAP:Grb2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:Grb2
type: Species

085072
stoichiometry: 1.0
species: 326401
type: SpeciesReference

111924
stoichiometry: 1.0
species: 326004
type: SpeciesReference

105327
stoichiometry: 1.0
species: 326771
type: SpeciesReference

328231
kinetic law: 104399
product: 104387
reactant: 104375
reactant: 104363
fast: false
reversible: true
name: v657 RTK_Pase + (EGF:ErbB1:ErbB2) -> (ErbB1:ErbB2)#P:RTK_Pase k95 kd95
type: Reaction

325980
notes: ATP 1.2e9
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.2E9
in compartment: 325908
name: ATP 1.2e9
type: Species

090408
stoichiometry: 1.0
species: 326549
type: SpeciesReference

106630
stoichiometry: 1.0
species: 326793
type: SpeciesReference

106099
stoichiometry: 1.0
species: 326273
type: SpeciesReference

328235
kinetic law: 104496
product: 104484
reactant: 104472
reactant: 104460
fast: false
reversible: true
name: v659 RTK_Pase + (EGF:ErbB1:ErbB4) -> (ErbB1:ErbB4)#P:RTK_Pase k95 kd95
type: Reaction

328577
kinetic law: 112747
product: 112735
reactant: 112723
reactant: 112711
fast: false
reversible: true
name: v851 EGF:ErbB1:Inh + EGF:ErbB1_h:ATP -> EGF:ErbB1:Inh::EGF:ErbB1_h:ATP k2 kd2
type: Reaction

083624
stoichiometry: 1.0
species: 326493
type: SpeciesReference

090504
stoichiometry: 1.0
species: 326541
type: SpeciesReference

095237
stoichiometry: 1.0
species: 326539
type: SpeciesReference

092649
stoichiometry: 1.0
species: 326487
type: SpeciesReference

096210
stoichiometry: 1.0
species: 326213
type: SpeciesReference

106846
stoichiometry: 1.0
species: 326809
type: SpeciesReference

325930
initial amount: 0.0
notes: 2(EGF:ErbB1:Inh) , plasma membrane
has part: P00533
boundary condition: false
type: Species
initial concentration: NaN
name: 2(EGF:ErbB1:Inh)
constant: false
has only substance units: true
in compartment: 325898
has version: P01133

077574
stoichiometry: 1.0
species: 326108
type: SpeciesReference

106991
stoichiometry: 1.0
species: 326815
type: SpeciesReference

107834
stoichiometry: 1.0
species: 326627
type: SpeciesReference

326809
notes: (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:Shp2
type: Species

106786
stoichiometry: 1.0
species: 326687
type: SpeciesReference

109062
stoichiometry: 1.0
species: 326869
type: SpeciesReference

327291
kinetic law: 083021
product: 083009
reactant: 082997
fast: false
reversible: true
name: v181 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k6b kd6b
type: Reaction

326887
notes: 2(EGF:ErbB1):Gab1#P##:Pase9t , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1):Gab1_P#:Pase9t
type: Species

326735
notes: AKT#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: AKT_P
type: Species

326453
notes: ErbB2:Inh , endosomal membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325906
name: ErbB2:Inh
type: Species

327445
kinetic law: 086581
product: 086569
reactant: 086556
reactant: 086544
fast: false
reversible: true
name: v259 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

112379
stoichiometry: 1.0
species: 325980
type: SpeciesReference

328129
kinetic law: 101965
product: 101953
reactant: 101941
fast: false
reversible: true
name: v606 (HRG:ErbB4):ErbB2) -> R_degraded k62b kd60b
type: Reaction

099560
stoichiometry: 1.0
species: 326407
type: SpeciesReference

327969
kinetic law: 099067
product: 099055
reactant: 099042
reactant: 099030
fast: false
reversible: true
name: v521 Pase3 + ERK#P -> ERK#P:Pase3 k58 kd58
type: Reaction

099200
stoichiometry: 1.0
species: 326431
type: SpeciesReference

328465
kinetic law: 110024
product: 110012
reactant: 110000
reactant: 109988
fast: false
reversible: true
name: v774 Pase9t + ErbB3/4:ErbB2:Gab1#P## -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k117 kd117
type: Reaction

079768
stoichiometry: 1.0
species: 326299
type: SpeciesReference

075061
stoichiometry: 1.0
species: 325926
type: SpeciesReference

079080
stoichiometry: 1.0
species: 326056
type: SpeciesReference

081525
stoichiometry: 1.0
species: 326309
type: SpeciesReference

325982
constant: false
in compartment: 325908
type: Species
has only substance units: true
has part: P00533
boundary condition: false
has version: P01133
notes: (EGF:ErbB1:ErbB2):ATP , cytoplasm
name: (EGF:ErbB1:ErbB2):ATP
initial concentration: NaN
initial amount: 0.0

103447
stoichiometry: 1.0
species: 326707
type: SpeciesReference

077719
stoichiometry: 1.0
species: 326120
type: SpeciesReference

328579
kinetic law: 112795
product: 112783
reactant: 112771
reactant: 112759
fast: false
reversible: true
name: v852 EGF:ErbB1_h:ATP + EGF:ErbB1_h:ATP -> 2(EGF:ErbB1_h:ATP) k2 kd2
type: Reaction

111624
stoichiometry: 1.0
species: 325980
type: SpeciesReference

327067
kinetic law: 077853
product: 077840
reactant: 077828
reactant: 077816
fast: false
reversible: true
name: v62 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

079164
stoichiometry: 1.0
species: 326269
type: SpeciesReference

077140
stoichiometry: 1.0
species: 326072
type: SpeciesReference

086315
stoichiometry: 1.0
species: 326377
type: SpeciesReference

075325
stoichiometry: 1.0
species: 325914
type: SpeciesReference

107618
stoichiometry: 1.0
species: 326823
type: SpeciesReference

092238
stoichiometry: 1.0
species: 326483
type: SpeciesReference

329267
constant: false
value: 1000000.0
name: k97c
type: Parameter

325932
has part: CHEBI:15422
in compartment: 325898
type: Species
notes: 2(EGF:ErbB1:ATP) , plasma membrane
constant: false
has part: P00533
has version: P01133
boundary condition: false
initial concentration: NaN
has only substance units: true
name: 2(EGF:ErbB1:ATP)
initial amount: 0.0

086652
stoichiometry: 1.0
species: 326108
type: SpeciesReference

086027
stoichiometry: 1.0
species: 326054
type: SpeciesReference

095009
stoichiometry: 1.0
species: 326577
type: SpeciesReference

326225
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
type: Species

329265
notes: % high affnity Iressa
constant: true
value: 3.0E-9
name: KD_iressa_mt
type: Parameter

102724
stoichiometry: 1.0
species: 326677
type: SpeciesReference

111420
stoichiometry: 1.0
species: 326915
type: SpeciesReference

327335
kinetic law: 083937
product: 083925
reactant: 083913
reactant: 083901
fast: false
reversible: true
name: v203 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8
type: Reaction

327963
kinetic law: 098921
product: 098909
reactant: 098897
reactant: 098885
fast: false
reversible: true
name: v518 ERK#P + Pase3 -> ERK#P#P:Pase3 k57 kd57
type: Reaction

326955
kinetic law: 075121
product: 075109
reactant: 075097
reactant: 075085
fast: false
reversible: true
name: v5 EGF:ErbB1:ATP + EGF:ErbB1:Inh -> (EGF:ErbB1:ErbB1):Inh k2 kd2
type: Reaction

090652
stoichiometry: 1.0
species: 326541
type: SpeciesReference

094911
stoichiometry: 1.0
species: 326577
type: SpeciesReference

325984
name: (EGF:ErbB1:ErbB3):ATP
initial concentration: NaN
has version: P01133
has only substance units: true
has part: P00533
boundary condition: false
initial amount: 0.0
type: Species
constant: false
in compartment: 325908
notes: (EGF:ErbB1:ErbB3):ATP , cytoplasm

080860
stoichiometry: 1.0
species: 326361
type: SpeciesReference

098453
stoichiometry: 1.0
species: 326613
type: SpeciesReference

102302
stoichiometry: 1.0
species: 326539
type: SpeciesReference

096294
stoichiometry: 1.0
species: 326523
type: SpeciesReference

327065
kinetic law: 077804
product: 077792
reactant: 077780
reactant: 077768
fast: false
reversible: true
name: v61 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

327069
kinetic law: 077901
product: 077889
reactant: 077877
reactant: 077865
fast: false
reversible: true
name: v63 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
type: Reaction

103904
stoichiometry: 1.0
species: 326753
type: SpeciesReference

089456
stoichiometry: 1.0
species: 326361
type: SpeciesReference

081733
stoichiometry: 1.0
species: 326397
type: SpeciesReference

094057
stoichiometry: 1.0
species: 326108
type: SpeciesReference

104652
stoichiometry: 1.0
species: 326755
type: SpeciesReference

325934
has version: P01133
has part: CHEBI:15422
has part: P00533
boundary condition: false
in compartment: 325906
has only substance units: true
type: Species
name: EGF:ErbB1:ATP
constant: false
notes: EGF:ErbB1:ATP , endosomal membrane
initial amount: 0.0
initial concentration: NaN

090252
stoichiometry: 1.0
species: 326289
type: SpeciesReference

102627
stoichiometry: 1.0
species: 326677
type: SpeciesReference

326227
notes: 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
type: Species

326731
constant: false
initial concentration: NaN
boundary condition: false
initial amount: 905000.0
in compartment: 325908
is version of: P31749
notes: AKT , cytoplasm
type: Species
has only substance units: true
name: AKT

100040
stoichiometry: 1.0
species: 326641
type: SpeciesReference

327965
kinetic law: 098970
product: 098958
reactant: 098946
reactant: 098934
fast: false
reversible: true
name: v519 ERK + Pase3 -> ERK#P:Pase3 k57 kd57
type: Reaction

088566
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327441
kinetic law: 086484
product: 086472
reactant: 086459
reactant: 086447
fast: false
reversible: true
name: v257 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
type: Reaction

083709
stoichiometry: 1.0
species: 326461
type: SpeciesReference

327333
kinetic law: 083889
product: 083877
reactant: 083865
reactant: 083853
fast: false
reversible: true
name: v202 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
type: Reaction

091372
stoichiometry: 1.0
species: 326541
type: SpeciesReference

329263
constant: false
value: 0.015
name: kd97
type: Parameter

326957
kinetic law: 075169
product: 075157
reactant: 075145
reactant: 075133
fast: false
reversible: true
name: v6 EGF:ErbB1:Inh + EGF:ErbB1:Inh -> 2(EGF:ErbB1:Inh) k2 kd2
type: Reaction

079528
stoichiometry: 1.0
species: 326299
type: SpeciesReference

078887
stoichiometry: 1.0
species: 326056
type: SpeciesReference

084373
stoichiometry: 1.0
species: 326521
type: SpeciesReference

101157
stoichiometry: 1.0
species: 326641
type: SpeciesReference

077865
stoichiometry: 1.0
species: 326132
type: SpeciesReference

325986
notes: (EGF:ErbB1:ErbB4):ATP , cytoplasm
has part: P00533
has only substance units: true
type: Species
constant: false
in compartment: 325908
initial concentration: NaN
boundary condition: false
initial amount: 0.0
has version: P01133
name: (EGF:ErbB1:ErbB4):ATP

102410
stoichiometry: 1.0
species: 326659
type: SpeciesReference

325936
name: 2(EGF:ErbB1:ATP)
initial amount: 0.0
initial concentration: NaN
has part: CHEBI:15422
boundary condition: false
has version: P01133
has only substance units: true
has part: P00533
type: Species
in compartment: 325906
notes: 2(EGF:ErbB1:ATP) , endosomal membrane
constant: false

080428
stoichiometry: 1.0
species: 326343
type: SpeciesReference

080752
stoichiometry: 1.0
species: 326309
type: SpeciesReference

084662
stoichiometry: 1.0
species: 326495
type: SpeciesReference

326060
notes: 2(EGF:ErbB1)#P:GAP:Grb2:Sos , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: 2(EGF:ErbB1)_P:GAP:Grb2:Sos
type: Species

088916
stoichiometry: 1.0
species: 326325
type: SpeciesReference

107267
stoichiometry: 1.0
species: 326014
type: SpeciesReference

112674
stoichiometry: 1.0
species: 326921
type: SpeciesReference

100112
stoichiometry: 1.0
species: 326641
type: SpeciesReference

084722
stoichiometry: 1.0
species: 326521
type: SpeciesReference

111576
stoichiometry: 1.0
species: 325980
type: SpeciesReference

084517
stoichiometry: 1.0
species: 326521
type: SpeciesReference

083359
stoichiometry: 1.0
species: 326481
type: SpeciesReference

104809
stoichiometry: 1.0
species: 326775
type: SpeciesReference

327227
kinetic law: 081708
product: 081696
reactant: 081684
reactant: 081672
fast: false
reversible: true
name: v148 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
type: Reaction

078634
stoichiometry: 1.0
species: 326225
type: SpeciesReference

075995
stoichiometry: 1.0
species: 325980
type: SpeciesReference

093260
stoichiometry: 1.0
species: 326539
type: SpeciesReference

097850
stoichiometry: 1.0
species: 326591
type: SpeciesReference

082611
stoichiometry: 1.0
species: 326415
type: SpeciesReference

086544
stoichiometry: 1.0
species: 326541
type: SpeciesReference

085169
stoichiometry: 1.0
species: 326357
type: SpeciesReference

109279
stoichiometry: 1.0
species: 326543
type: SpeciesReference

327181
kinetic law: 080596
product: 080584
reactant: 080572
reactant: 080560
fast: false
reversible: true
name: v123 cPP + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:cPP k5 kd5b
type: Reaction

097729
stoichiometry: 1.0
species: 326595
type: SpeciesReference

077647
stoichiometry: 1.0
species: 326114
type: SpeciesReference

326503
notes: (ErbB1:ErbB3)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB3)_P:GAP
type: Species

326881
notes: Raf:P:Ser , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: Raf:P:Ser
type: Species

328121
kinetic law: 101821
product: 101809
reactant: 101797
fast: false
reversible: true
name: v602 (EGF:ErbB1:ErbB4) -> R_degraded k62b kd60b
type: Reaction

081305
stoichiometry: 1.0
species: 326142
type: SpeciesReference

091264
stoichiometry: 1.0
species: 326363
type: SpeciesReference

105967
stoichiometry: 1.0
species: 326801
type: SpeciesReference

077780
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327225
kinetic law: 081659
product: 081647
reactant: 081635
reactant: 081623
fast: false
reversible: true
name: v147 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

326801
notes: Gab1 , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 94868.3
in compartment: 325908
name: Gab1
type: Species

083925
stoichiometry: 1.0
species: 326509
type: SpeciesReference

096500
stoichiometry: 1.0
species: 326245
type: SpeciesReference

106918
stoichiometry: 1.0
species: 326805
type: SpeciesReference

088058
stoichiometry: 1.0
species: 326353
type: SpeciesReference

325938
constant: false
in compartment: 325898
type: Species
initial concentration: NaN
boundary condition: false
has only substance units: true
is version of: P04626
initial amount: 462000.0
notes: ErbB2 , plasma membrane
name: ErbB2

094561
stoichiometry: 1.0
species: 326429
type: SpeciesReference

101266
stoichiometry: 1.0
species: 326641
type: SpeciesReference

105689
stoichiometry: 1.0
species: 326787
type: SpeciesReference

078730
stoichiometry: 1.0
species: 326233
type: SpeciesReference

327961
kinetic law: 098873
product: 098861
reactant: 098849
reactant: 098837
fast: false
reversible: true
name: v517 (ERK#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k57 kd57
type: Reaction

078490
stoichiometry: 1.0
species: 326213
type: SpeciesReference

090360
stoichiometry: 1.0
species: 326547
type: SpeciesReference

326505
notes: (ErbB1:ErbB4)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB4)_P:GAP
type: Species

104435
stoichiometry: 1.0
species: 326757
type: SpeciesReference

102398
stoichiometry: 1.0
species: 326669
type: SpeciesReference

079418
stoichiometry: 1.0
species: 326056
type: SpeciesReference

327811
kinetic law: 095273
product: 095261
reactant: 095249
reactant: 095237
fast: false
reversible: true
name: v442 Sos + Grb2 -> Grb2:Sos k35 kd35
type: Reaction

328237
kinetic law: 104544
product: 104532
reactant: 104520
reactant: 104508
fast: false
reversible: true
name: v660 RTK_Pase + 2(EGF:ErbB1:ATP) -> 2(EGF:ErbB1)#P:RTK_Pase k95 kd95
type: Reaction

087325
stoichiometry: 1.0
species: 326253
type: SpeciesReference

081149
stoichiometry: 1.0
species: 326373
type: SpeciesReference

326803
has part: P27986
initial concentration: NaN
notes: PI3K , cytoplasm
has part: P42338
in compartment: 325908
type: Species
boundary condition: false
has part: O00459
initial amount: 0.0
name: PI3K
constant: false
has part: P42336
has only substance units: true
is version of: REACT 4240.1

327223
kinetic law: 081610
product: 081598
reactant: 081586
reactant: 081574
fast: false
reversible: true
name: v146 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

327551
kinetic law: 089132
product: 089120
reactant: 089108
reactant: 089096
fast: false
reversible: true
name: v312 (Ras_activated:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

092094
stoichiometry: 1.0
species: 326497
type: SpeciesReference

098934
stoichiometry: 1.0
species: 326613
type: SpeciesReference

084300
stoichiometry: 1.0
species: 326054
type: SpeciesReference

327185
kinetic law: 080691
product: 080680
reactant: 080668
reactant: 080656
fast: false
reversible: true
name: v125 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

328571
kinetic law: 112601
product: 112589
reactant: 112576
reactant: 112564
fast: false
reversible: true
name: v828 ErbB1 + ATP -> ErbB1:ATP k122 kd122
type: Reaction

092757
stoichiometry: 1.0
species: 326553
type: SpeciesReference

081889
stoichiometry: 1.0
species: 326094
type: SpeciesReference

082057
stoichiometry: 1.0
species: 326309
type: SpeciesReference

328123
kinetic law: 101857
product: 101845
reactant: 101833
fast: false
reversible: true
name: v603 (HRG:ErbB3:ErbB1) -> R_degraded k62b kd60b
type: Reaction

326885
notes: Pase9t , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Pase9t
type: Species

326671
notes: Sos#P , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: Sos_P
type: Species

328467
kinetic law: 110074
product: 110061
reactant: 110049
reactant: 110036
fast: false
reversible: true
name: v775 Pase9t + ErbB1:ErbB:Gab1#P## -> ErbB1:ErbB:Gab1#P##:Pase9t k117 kd117
type: Reaction

095345
stoichiometry: 1.0
species: 326437
type: SpeciesReference

328927
constant: false
units: item
value: NaN
name: total ERB-B1_P
type: Parameter

087193
stoichiometry: 1.0
species: 326353
type: SpeciesReference

327689
kinetic law: 092491
product: 092479
reactant: 092467
fast: false
reversible: true
name: v381 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
type: Reaction

099644
stoichiometry: 1.0
species: 326641
type: SpeciesReference

104168
stoichiometry: 1.0
species: 326755
type: SpeciesReference

076850
stoichiometry: 1.0
species: 326046
type: SpeciesReference

328573
kinetic law: 112650
product: 112638
reactant: 112626
reactant: 112613
fast: false
reversible: true
name: v829 ErbB1_h + ATP -> ErbB1_h:ATP k122 kd122
type: Reaction

106340
stoichiometry: 1.0
species: 326793
type: SpeciesReference

328239
kinetic law: 104592
product: 104580
reactant: 104568
reactant: 104556
fast: false
reversible: true
name: v661 RTK_Pase + 2(ErbB2) -> 2(ErbB2)#P:RTK_Pase k95 kd95
type: Reaction

327813
kinetic law: 095309
product: 095297
reactant: 095285
fast: false
reversible: true
name: v443 (Shc#P) + -> Shc k36 kd36
type: Reaction

327553
kinetic law: 089180
product: 089168
reactant: 089156
reactant: 089144
fast: false
reversible: true
name: v313 Ras_activated:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
type: Reaction

100473
stoichiometry: 1.0
species: 326641
type: SpeciesReference

326805
initial concentration: NaN
in compartment: 325908
is version of: Q06124
type: Species
constant: false
boundary condition: false
name: Shp2
initial amount: 1000000.0
notes: Shp2 , cytoplasm
has only substance units: true

327221
kinetic law: 081562
product: 081550
reactant: 081537
reactant: 081525
fast: false
reversible: true
name: v145 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
type: Reaction

327183
kinetic law: 080644
product: 080632
reactant: 080620
reactant: 080608
fast: false
reversible: true
name: v124 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
type: Reaction

075435
stoichiometry: 1.0
species: 325950
type: SpeciesReference

328929
constant: false
units: item
value: NaN
type: Parameter

326883
notes: MKP_deg , cytoplasm
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325908
name: MKP_deg
type: Species

328469
kinetic law: 110123
product: 110111
reactant: 110098
reactant: 110086
fast: false
reversible: true
name: v776 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k117 kd117
type: Reaction

097513
stoichiometry: 1.0
species: 326583
type: SpeciesReference

100533
stoichiometry: 1.0
species: 326359
type: SpeciesReference

112262
stoichiometry: 1.0
species: 326465
type: SpeciesReference

328125
kinetic law: 101893
product: 101881
reactant: 101869
fast: false
reversible: true
name: v604 (HRG:ErbB4:ErbB1) -> R_degraded k62b kd60b
type: Reaction

326501
notes: (ErbB1:ErbB2)#P:GAP , plasma membrane
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 325898
name: (ErbB1:ErbB2)_P:GAP
type: Species

096836
stoichiometry: 1.0
species: 326100
type: SpeciesReference

107111
stoichiometry: 1.0
species: 326805
type: SpeciesReference