v483 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v422 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1 , plasma membrane
v8 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP) k2 kd2
v682 ErbB2#P + ErbB2:Inh -> ErbB2:ErbB2:Inh k103 kd103
v482 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v716 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v437 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
v685 ErbB2 + ErbB4:Inh -> ErbB4:Inh:ErbB2 k103 kd103
v715 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v721 PIP3 + PTEN -> PIP3:PTEN k109 kd109
2(ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
v10 EGF:ErbB1:ATP + ErbB3 -> EGF:ErbB1:ErbB3 k2b kd2b
v684 ErbB2:Inh + ErbB4 -> ErbB4:ErbB2:Inh k103 kd103
v54 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v306 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v714 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v273 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v822 (ErbB1:ErbB3)#P + ATP -> (HRG:ErbB3:ErbB1):ATP k123 kd123
v9 EGF:ErbB1:ATP + ErbB2 -> EGF:ErbB1:ErbB2 k2b kd2b
v720 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k108 kd108
2(ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v272 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v683 ErbB2:Inh + ErbB3 -> ErbB3:ErbB2:Inh k103 kd103
v197 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8
v274 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v713 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k107 kd107
v305 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v744 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v719 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v568 2(ErbB2)#P:GAP:Shc -> R_degraded k60b kd60
v304 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v275 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v196 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) , plasma membrane
v712 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v567 2(ErbB2)#P:GAP -> R_degraded k60b kd60
v718 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v743 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
v717 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v303 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v276 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v134 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v746 (ERK#P#P)_i + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v368 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22
v302 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v367 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22
v745 ERK#P#P + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
v565 (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v533 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60 kd60
v364 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v610 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
(ErbB1:ErbB4)#P:GAP:(Shc#P) , endosomal membrane
v823 (ErbB1:ErbB4)#P + ATP -> (HRG:ErbB4:ErbB1):ATP k123 kd123
v130 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b
v307 Ras:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v492 MEK + (Raf#P)_i -> (MEK:Raf#P)_i k44 kd52
v195 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v532 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> R_degraded k60 kd60
v363 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P) , endosomal membrane
v609 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
v133 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v165 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P k6 kd6
v493 MEK + Raf#P -> MEK:Raf#P k44 kd52
v194 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8b kd8b
v366 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v608 (ErbB4:ErbB2) -> R_degraded k62b kd60b
v748 (ERK#P#P)_i + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k111 kd111
v535 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + -> R_degraded k60 kd60
v128 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k5 kd5b
v494 MEK#P + Raf#P -> MEK#P:Raf#P k44 kd52
v193 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k7 kd7
2(EGF:ErbB1)#P:GAP:Grb2:Sos , endosomal membrane
v569 2(ErbB2)#P:GAP:(Shc#P) -> R_degraded k60b kd60
v747 ERK#P#P + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k111 kd111
v365 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v534 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60
v129 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k5 kd5b
v421 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v495 MEK#P + Raf#P -> MEK:Raf#P k45 kd45
v192 2(ErbB2)#P:GAP:Shc -> 2(ErbB2)#P:GAP:Shc k7 kd7
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v607 (ErbB3:ErbB2) -> R_degraded k62b kd60b
v12 EGF:ErbB1:ATP + ErbB2 -> (EGF:ErbB1:ErbB2) k2b kd2b
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1 , plasma membrane
v440 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v420 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v57 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v481 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v827 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2):ATP k123 kd123
v441 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v55 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
(ErbB4:ErbB2)#P:GAP:Grb2 , plasma membrane
v11 ErbB4 + EGF:ErbB1:ATP -> EGF:ErbB1:ErbB4 k2b kd2b
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v419 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v480 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v686 Shp + PIP2 -> PIP3:Shp k104 kd104
v826 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2):ATP k123 kd123
v56 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v161 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k5 kd5
(ErbB4:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
v438 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v825 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2:ATP k123 kd123
v479 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB3:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v418 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v162 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k5 kd5
v611 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k64 kd64
v439 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P) , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v824 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2:ATP k123 kd123
v58 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v163 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k6 kd6
v478 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
v417 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v82 2(ErbB2)#P:GAP:Grb2 + cPP -> 2(ErbB2)#P:GAP:Grb2:cPP k4b kd4
v710 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v427 (Shc#P) + Grb2:Sos -> (Shc#P):Grb2:Sos k33 kd33
v13 EGF:ErbB1:ATP + ErbB3 -> (EGF:ErbB1:ErbB3) k2b kd2b
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v687 PTEN + PIP2 -> PIP3:PTEN k104 kd104
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P , plasma membrane
v83 2(ErbB2)#P:GAP:Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
v711 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v477 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v428 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
v14 EGF:ErbB1:ATP + ErbB4 -> (EGF:ErbB1:ErbB4) k2b kd2b
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v688 2(EGF:ErbB1)#P:GAP:Grb2 + Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 k105 kd105
v300 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v816 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k123 kd123
v708 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v15 EGF:ErbB1:Inh + ErbB2 -> EGF:ErbB1:Inh:ErB2 k2b kd2b
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v726 (ERK#P#P)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v689 (ErbB1:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v817 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k123 kd123
v691 (ErbB1:ErbB4)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 k105 kd105
v301 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v81 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v709 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP , plasma membrane
v16 ErbB3 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB3 k2b kd2b
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
v690 (ErbB1:ErbB3)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 k105 kd105
v560 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v232 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63
v269 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
v298 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v724 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k110 kd110
v559 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v612 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k64 kd64
v707 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v299 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
v191 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP k7 kd7
v268 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v267 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v725 ERK#P#P + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
v372 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
v558 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v722 PIP3 + Shp -> PIP3:Shp k109 kd109
(ErbB1:ErbB4)#P:RTK_Pase , endosomal membrane
v271 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP , plasma membrane
v373 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
v723 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k110 kd110
v270 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v297 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB3)#P:RTK_Pase , endosomal membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v374 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b
(ErbB1:ErbB4)#P:GAP:Grb2:Sos , plasma membrane
v615 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
v369 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
v236 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v487 Pase1 + (Raf#P)_i -> (Raf#P:Pase1)_i k42 kd42
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v159 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v616 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k65 kd65
v370 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
v527 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> R_degraded k60 kd60
v235 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v266 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v189 (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P k7 kd7
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v158 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k5 kd5
v528 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60
(ErbB1:ErbB2)#P:GAP:(Shc#P) , plasma membrane
v371 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b
v186 (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P k7 kd7
v476 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v489 Raf + Pase1 -> Raf#P:Pase1 k43 kd43
v613 ERK#P#P + Sos -> (ERK#P#P):Sos k64 kd64
v234 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v564 (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v529 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60 kd60
(ErbB1:ErbB3)#P:GAP:(Shc#P) , plasma membrane
v742 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v187 (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P k7 kd7
v160 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v488 Pase1 + Raf#P -> Raf#P:Pase1 k42 kd42
v233 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v563 (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v48 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k4 kd4
v530 2(EGF:ErbB1)#P:GAP:Shc -> R_degraded k60 kd60
v17 ErbB4 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB4 k2b kd2b
(ErbB1:ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v820 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
2(EGF:ErbB1)#P:GAP:Grb2 , endosomal membrane
v425 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v474 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
v49 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4 kd4
v531 2(EGF:ErbB1)#P:GAP:(Shc#P) -> R_degraded k60 kd60
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
v490 Raf + Pase1 -> (Raf#P:Pase1)_i k43 kd43
v426 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v475 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v50 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4 kd4
v821 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k123 kd123
v156 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5
(ErbB1:ErbB3)#P:GAP:Grb2:Sos , plasma membrane
v472 Sos + (Shc#P):Grb2 -> (Shc#P):Grb2:Sos k40 kd40
v706 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k106 kd106
v157 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v423 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v52 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v818 2(ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v190 (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P k7 kd7
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP , plasma membrane
v473 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
(ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v424 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v819 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v53 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
(ErbB4:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
2(EGF:ErbB1)#P:RTK_Pase , endosomal membrane
v703 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k106 kd106
v786 HRG:ErbB3 + ErbB2 -> (HRG:ErbB3):ErbB2 k120 kd120
v295 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v811 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1):ATP k123 kd123
v284 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v283 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v432 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34
v672 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101
v647 AKT + Pase4 -> AKT#P:Pase4 k75 kd75
v239 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd24
v394 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23
(ErbB1:ErbB3)#P:GAP:Shc , endosomal membrane
v22 (EGF:ErbB1:ErbB3) + ATP -> (EGF:ErbB1:ErbB3):ATP k122 kd122
v294 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v785 ErbB4 + HRG -> HRG:ErbB4 k119 kd119
2(ErbB2)#P:RTK_Pase , endosomal membrane
v810 (ErbB1:ErbB4)#P + ATP -> (EGF:ErbB1:ErbB4):ATP k123 kd123
v702 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k106 kd106
v285 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v393 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
v21 (EGF:ErbB1:ErbB2) + ATP -> (EGF:ErbB1:ErbB2):ATP k122 kd122
v238 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd24
v434 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34
v784 HRG + ErbB3 -> HRG:ErbB3 k119 kd119
v705 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k106 kd106
v783 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k118 kd118
v237 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd63
v392 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
v20 EGF:ErbB1:ATP + ErbB3:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
(ErbB1:ErbB3)#P:GAP:Grb2:cPP , plasma membrane
v812 (ErbB1:ErbB3)#P + ATP -> EGF:ErbB1:ErbB3:ATP k123 kd123
v433 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v704 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k106 kd106
v296 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v782 Pase9t + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB1:ErbB:Gab1#P##:Pase9t k118 kd118
v282 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB1:ErbB3)#P:GAP:Grb2 , plasma membrane
v576 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v19 EGF:ErbB1:ATP + ErbB4:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
(ErbB1:ErbB2)#P:RTK_Pase , endosomal membrane
(ErbB1:ErbB4)#P:GAP:Grb2 , plasma membrane
v502 MEK + Pase2 -> MEK#P:Pase2 k49 kd49
v729 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k110 kd110
v18 EGF:ErbB1:ATP + ErbB2:Inh -> (EGF:ErbB1:ErbB2):Inh k2b kd2b
v577 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v651 RTK_Pase + (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P:RTK_Pase k94b kd94
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v503 MEK + Pase2 -> (MEK#P:Pase2)_i k49 kd49
(ErbB1:ErbB4)#P:GAP:Grb2:cPP , plasma membrane
v728 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v650 RTK_Pase + (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P:RTK_Pase k94b kd94
v579 (ErbB3:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v286 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v293 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P , endosomes
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
(ErbB2:ErbB3)#P:RTK_Pase , endosomal membrane
v618 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
v581 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
v580 (ErbB4:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60
v756 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v731 ERK#P#P + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
v241 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v649 PDK1 + PIP3 -> PIP3:PDK1 k76 kd76
(ErbB2:ErbB4)#P:RTK_Pase , endosomal membrane
v292 (Ras:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
v617 ERK#P#P + Sos#P -> (ERK#P#P):Sos k65 kd65
v755 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v240 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd63
v730 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v648 AKT#P + Pase4 -> AKT#P#P:Pase4 k75 kd75
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v354 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v760 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v227 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24
v506 Pase2 + MEK#P -> MEK#P:Pase2 k50 kd50
v471 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2 , endosomal membrane
v619 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k65 kd65
v759 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v353 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v228 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
v470 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , endosomes
(ErbB3:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
This is A431 IERMv1.0 model described in the article Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger and Peter K Sorger. Molecular Systems Biology 2009; 5:239. PMID: 19156131 , DOI: 10.1038/msb.2008.74 Abstract: The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affected by oncogenic mutations. To quantify signal flow through ErbB-activated pathways we have constructed, trained and analyzed a mass action model of immediate-early signaling involving ErbB1-4 receptors (EGFR, HER2/Neu2, ErbB3 and ErbB4), and the MAPK and PI3K/Akt cascades. We find that parameter sensitivity is strongly dependent on the feature (e.g. ERK or Akt activation) or condition (e.g. EGF or heregulin stimulation) under examination and that this context dependence is informative with respect to mechanisms of signal propagation. Modeling predicts log-linear amplification so that significant ERK and Akt activation is observed at ligand concentrations far below the K(d) for receptor binding. However, MAPK and Akt modules isolated from the ErbB model continue to exhibit switch-like responses. Thus, key system-wide features of ErbB signaling arise from nonlinear interaction among signaling elements, the properties of which appear quite different in context and in isolation. The sbml model is available as supplemental material to the article and at http://www.cdpcenter.org/resources/models/chen-et-al-2008/ . It was slightly changed to make it valid SBML and to incorporate the step functions, described in the readme file and needed for inhibitor preincubation. the equilibration processes end at 1800 sec, so to reproduce the dynamics shown in the publication and supplemental material, only the time points after 1800 need to be considered. The parameter set is the hand fitted one used for Sfigure 3 in the supplemental materials. All species are in molecules, apart from HRG, EGF and Inh, which are in M. The results shown in SFigure 3 can be calculated dividing the parameters ERK_PP , AKT_PP and ERB_B1_P_tot by ERK_t , AKT_t and EGFR_t , respectively. Somehow we did not find the right scaleing factor for the phosphorylated ErbB1 receptor. Therefore the model does only qualitatively reproduces the timecourses shown in the first row of Sfigure 3. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Nov������re N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
v229 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v352 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v758 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k113 kd113
v727 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , endosomal membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2 , endosomal membrane
v504 (MEK#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k49 kd49
v646 AKT#P + Pase4 -> AKT#P:Pase4 k73 kd73
v230 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
(ErbB1:ErbB2)#P:GAP:Shc , endosomal membrane
v621 PI3K + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v757 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v505 Pase2 + (MEK#P)_i -> (MEK#P:Pase2)_i k50 kd50
v47 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k4 kd4
(ErbB1:ErbB4)#P:GAP:Shc , plasma membrane
2(ErbB2)#P:GAP:(Shc#P) , plasma membrane
v231 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63
v813 (ErbB1:ErbB4)#P + ATP -> EGF:ErbB1:ErbB4:ATP k123 kd123
v46 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v701 PIP2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> PI3K k106 kd106
v174 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k6 kd6
v467 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37
v430 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
(ErbB1:ErbB3)#P:GAP:Shc , plasma membrane
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v45 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4 kd4
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v676 EGF:ErbB1#P + ErbB4#P -> (ErbB1:ErbB4)#P k102 kd102
v429 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
v700 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106
v175 2(EGF:ErbB1)#P:GAP:Grb2 + -> 2(EGF:ErbB1)#P:GAP:Grb2 k6 kd6
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
(ErbB1:ErbB2)#P:GAP:Shc , plasma membrane
v396 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v356 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v43 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k4 kd4
v171 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k6 kd6
v469 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v815 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v675 EGF:ErbB1#P + ErbB3#P -> (ErbB1:ErbB3)#P k102 kd102
v44 2(EGF:ErbB1)#P:GAP:Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k4 kd4
v395 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v355 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v673 EGF:ErbB1#P + EGF:ErbB1#P -> 2(EGF:ErbB1)#P k102 kd102
v172 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k6 kd6
v173 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k6 kd6
v468 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v674 ErbB2#P + EGF:ErbB1#P -> (ErbB1:ErbB2)#P k102 kd102
v431 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v814 2(ErbB2)#P + ATP -> ErbB2:ErbB2#P:ATP k123 kd123
v279 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v288 (Ras:GTP)_i + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v677 ErbB2#P + ErbB2 -> ErbB2:ErbB2#P k103 kd103
v278 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v335 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v27 EGF:ErbB1:ErbB3 + ATP -> EGF:ErbB1:ErbB3:ATP k122 kd122
2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v387 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23
v805 EGF:ErbB1:ErbB1_h:Inh + ATP -> k122 kd122
v697 PIP2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v289 Ras:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v678 ErbB2 + ErbB3 -> (ErbB2:ErbB3) k103 kd103
v277 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
2(EGF:ErbB1)#P:GAP:Grb2:Gab1 , plasma membrane
v334 2(ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v388 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23
v698 PIP2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v290 (Ras:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
(EGF:ErbB1:ErbB3)#P:Inh , plasma membrane
v291 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v790 HRG:ErbB4 + ErbB1:ATP -> (HRG:ErbB4:ErbB1) k120b kd120
v699 PIP2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106
v807 (ErbB1:ErbB2)#P + ATP -> EGF:ErbB1:ErbB2:ATP k123 kd123
v789 HRG:ErbB3 + ErbB1:ATP -> (HRG:ErbB3:ErbB1) k120b kd120
v336 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
v26 EGF:ErbB1:ErbB2 + ATP -> EGF:ErbB1:ErbB2:ATP k122 kd122
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v497 MEK#P#P + Raf#P -> MEK#P:Raf#P k47 kd47
v734 (ERK#P#P)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP , cytoplasm
v751 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k112 kd112
v572 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v644 AKT#P#P + PIP3:PDK1 -> PIP3:AKT#P:PDK1 k72 kd72
v23 (EGF:ErbB1:ErbB4) + ATP -> (EGF:ErbB1:ErbB4):ATP k122 kd122
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 , plasma membrane
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
v622 PI3K + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v570 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
v645 AKT#P#P + Pase4 -> AKT#P#P:Pase4 k74 kd74
v362 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v24 2(EGF:ErbB1:ATP) + ATP -> 2(EGF:ErbB1):ATP k122 kd122
v735 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
v281 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v333 2(ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v575 2(ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v623 PI3K + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v736 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v642 PDK1 + PIP3:AKT -> PIP3:AKT:PDK1 k70 kd70
v749 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 , plasma membrane
v287 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
(ErbB1:ErbB2)#P:GAP:Grb2 , plasma membrane
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v280 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
v574 2(ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60
v332 (Ras_activated:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v624 PI3K + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
v643 PIP3:PDK1 + AKT#P -> PIP3:AKT:PDK1 k71 kd71
v573 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v750 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v359 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v625 PI3K + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
v753 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v501 MEK#P + Pase2 -> MEK#P#P:Pase2 k49 kd49
v222 (ErbB1:ErbB4)#P:GAP + Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v464 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
v360 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v754 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v626 PI3K + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
2(ErbB2)#P:GAP:(Shc#P) , endosomal membrane
ErbB3/4:ErbB2:Gab1#P## , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v500 MEK#P#P + Pase2 -> MEK#P#P:Pase2 k48 kd48
v465 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
v224 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24
v357 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v732 (ERK#P#P)_i + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v41 (HRG:ErbB3):ErbB2) + ATP -> (HRG:ErbB3):ErbB2):ATP k122 kd122
v499 (MEK#P#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k48 kd48
v466 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v752 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v358 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v223 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v733 ERK#P#P + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v42 (HRG:ErbB4):ErbB2) + ATP -> (HRG:ErbB4):ErbB2):ATP k122 kd122
v170 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k6 kd6
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v226 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
(ErbB1:ErbB4)#P:GAP , endosomal membrane
v38 (HRG:ErbB4:ErbB1) + ATP -> (HRG:ErbB4:ErbB1):ATP k122 kd122
v391 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23
(ErbB3:ErbB2)#P:GAP:Grb2 , plasma membrane
v435 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34
v169 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k6 kd6
(ErbB3:ErbB2)#P:GAP:Grb2:cPP , plasma membrane
v39 (HRG:ErbB4):ErbB2 + ATP -> (HRG:ErbB4):ErbB2:ATP k122 kd122
v694 (ErbB4:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v225 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
v787 (HRG:ErbB3) + ErbB2 -> (HRG:ErbB3):ErbB2) k120 kd120
v167 2(EGF:ErbB1)#P:GAP:Shc -> 2(EGF:ErbB1)#P:GAP:Shc k6 kd6
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v436 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
v695 PIP2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v168 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k6 kd6
v40 (HRG:ErbB3):ErbB2 + ATP -> (HRG:ErbB3):ErbB2:ATP k122 kd122
v389 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
v361 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB2)#P:GAP , endosomal membrane
v166 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP k6 kd6
v679 ErbB2 + ErbB4 -> ErbB2:ErbB4 k103 kd103
v680 ErbB2#P + ErbB3#P -> (ErbB3:ErbB2)#P k103 kd103
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v808 (ErbB1:ErbB2)#P + ATP -> (EGF:ErbB1:ErbB2):ATP k123 kd123
v696 PIP2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v462 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1 , plasma membrane
v390 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
(ErbB1:ErbB3)#P:GAP , endosomal membrane
2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v809 (ErbB1:ErbB3)#P + ATP -> (EGF:ErbB1:ErbB3):ATP k123 kd123
v681 ErbB2#P + ErbB4#P -> (ErbB4:ErbB2)#P k103 kd103
v463 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
((HRG:ErbB4):ErbB2) , endosomal membrane
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , endosomal membrane
v109 cPP + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k5b kd5b
v137 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v98 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
v97 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) , plasma membrane
v803 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k123 kd123
((HRG:ErbB4):ErbB2):ATP , endosomal membrane
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v110 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
v351 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v138 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v107 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
v76 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k4b kd4
2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) , endosomal membrane
v741 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k111 kd111
v402 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
2(EGF:ErbB1)#P:GAP:Grb2 , plasma membrane
v590 (ErbB3:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
v139 cPP + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k5 kd5b
v350 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v547 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v108 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , endosomal membrane
v591 (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60
v349 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB4)#P:GAP:Shc , endosomal membrane
v326 Ras_activated:GTP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v588 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
2(EGF:ErbB1)#P:GAP:Grb2:cPP , plasma membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v249 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB4:ErbB2)#P:GAP:(Shc#P) , plasma membrane
v404 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v78 2(ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v546 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v348 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v693 (ErbB3:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v248 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17
v589 (ErbB4:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
v403 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v516 (ERK#P#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k56 kd56
v77 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k4b kd4
v545 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
v347 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v101 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
v692 2(ErbB2)#P:GAP:Grb2 + Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v406 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v251 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v544 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
v631 PIP3 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v100 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v543 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60
v111 cPP + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k5b kd5b
v250 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
v405 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v587 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
(ErbB4:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v79 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v80 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v99 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v457 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v663 RTK_Pase + (ErbB4:ErbB2) -> (ErbB2:ErbB4)#P:RTK_Pase k95 kd95
v629 PIP3 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v662 RTK_Pase + (ErbB3:ErbB2) -> (ErbB2:ErbB3)#P:RTK_Pase k95 kd95
v327 Ras_activated:GTP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v221 (ErbB1:ErbB3)#P:GAP + Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
v513 ERK#P#P + MEK#P#P -> ERK#P:MEK#P#P k55 kd55
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v630 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K + PIP3 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v512 MEK#P#P + ERK#P -> ERK:MEK#P#P k53 kd53
v767 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser k115 kd115
v665 ErbB1 + Inh -> ErbB1:Inh k97 kd97
v627 PI3K + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v768 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser_i k115 kd115
v515 ERK#P#P + Pase3 -> ERK#P#P:Pase3 k56 kd56
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v219 Grb2 + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24
(EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive , plasma membrane
v253 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
v802 (EGF:ErbB1:ErbB1):Inh + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k122 kd122
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 , plasma membrane
v664 ErbB2#P + ErbB2#P -> 2(ErbB2)#P k96 kd96
v628 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68b
v514 (ERK#P#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK#P k55 kd55
v252 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v220 (ErbB1:ErbB2)#P:GAP + Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
(ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v331 Ras_activated:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v217 Grb2 + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
v799 ErbB1_h:ATP + -> ErbB1_h:ATP k6 kd6
ErbB3/4:ErbB2:Gab1#P##:Pase9t , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v770 Pase9t + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1):Gab1#P##:Pase9t k117 kd117
(EGF:ErbB1:ATP::EGF:ErbB1_h:ATP) , plasma membrane
v330 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v140 cPP + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k5 kd5b
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
2(ErbB2)#P:GAP:Grb2 , endosomal membrane
v666 ErbB2 + Inh -> ErbB2:Inh k98 kd98
v738 (ERK#P#P)_i + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , cytoplasm
v218 Grb2 + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
v801 ErbB1_h:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P , plasma membrane
ErbB1:ErbB:Gab1#P##:Pase9t , plasma membrane
v459 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37
2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v141 cPP + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k5 kd5b
v329 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
2(ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
v737 ERK#P#P + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t , endosomal membrane
v797 EGF:ErbB1_h:Inh + EGF:ErbB1_h:Inh -> 2(EGF:ErbB1_h:Inh) k2 kd2
2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v328 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v458 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v142 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v798 EGF + ErbB1_h:ATP -> EGF:ErbB1_h:ATP k1 kd1
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t , plasma membrane
v246 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
v761 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v345 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v103 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v116 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v104 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v346 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v115 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P , plasma membrane
v541 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
(ErbB1:ErbB3)#P:GAP:Grb2:Sos , endosomal membrane
v585 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v586 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
v320 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v114 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b
v343 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v456 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37
v542 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
v102 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
v113 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v584 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Sos , endosomal membrane
v344 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v321 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v510 (MEK#P#P)_i + (ERK#P)_i -> MEK#P#P:ERK#P k52 kd44
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v242 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
((HRG:ErbB3):ErbB2):ATP , plasma membrane
v397 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v583 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60
2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v69 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v511 (ERK#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK k53 kd53
v398 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v582 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
v243 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
((HRG:ErbB3):ErbB2) , endosomal membrane
v540 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
v70 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
v342 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
v244 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v399 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v71 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
v105 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b
(ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v400 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v245 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v72 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4
(ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v75 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
v106 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v636 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k68 kd68b
v667 ErbB4 + Inh -> ErbB4:Inh k99 kd99
v401 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v595 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
(ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v216 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24
(EGF:ErbB1:Inh::EGF:ErbB1_h:ATP) , plasma membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v669 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P k101 kd101
v635 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k68 kd68b
v668 ErbB3 + Inh -> ErbB3:Inh k100 kd100
v215 2(EGF:ErbB1)#P:GAP + Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63
v507 ERK + MEK#P#P -> ERK:MEK#P#P k52 kd44
2(EGF:ErbB1_h:ATP)-FullActive , plasma membrane
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v596 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v862 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k123h kd123h
v670 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) k101 kd101
v634 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k68 kd68b
v214 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24
v796 EGF:ErbB1:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1:ErbB1_h:Inh k2 kd2
v593 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v508 MEK#P#P + ERK#P -> ERK#P:MEK#P#P k52 kd44
v671 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101
v633 PIP3 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v795 EGF + ErbB1_h:Inh -> EGF:ErbB1_h:Inh k1 kd1
v247 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17
(EGF:ErbB1:Inh::EGF:ErbB1_h:Inh) , plasma membrane
2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 , plasma membrane
v762 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v594 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v509 ERK + (MEK#P#P)_i -> MEK#P#P:ERK k52 kd44
v454 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v860 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k123h kd123h
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i , plasma membrane
v324 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v212 Grb2 + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63
2(ErbB2)#P:GAP:Grb2:Gab1#P , plasma membrane
v763 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v794 ErbB1_h + Inh -> ErbB1_h:Inh k97c kd97c
v112 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
(EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive , plasma membrane
v632 PIP3 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v861 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k123 kd123
v455 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37
v325 Ras_activated:GTP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P , plasma membrane
v592 (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60
v793 ErbB1:ATP + (HRG:ErbB4) -> (HRG:ErbB4:ErbB1) k120b kd120
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K , plasma membrane
v764 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
2(ErbB2)#P:GAP:(Shc#P):Grb2 , endosomal membrane
v136 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v452 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i , plasma membrane
v765 AKT#P#P + Raf#P -> AKT:P:P:Raf:P:Ser k114 kd114
v792 ErbB1:ATP + (HRG:ErbB3) -> (HRG:ErbB3:ErbB1) k120b kd120
v858 EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k122 kd122
v322 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v323 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v135 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P , plasma membrane
(ErbB1:ErbB4)#P:GAP:Grb2:Sos , endosomal membrane
v453 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
v766 AKT#P#P + (Raf#P)_i -> AKT:P:P:Raf:P:Ser_i k114 kd114
v859 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k123 kd123
v414 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v380 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22
v32 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k122 kd122
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
v120 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v451 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37
v338 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v315 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v31 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k122 kd122
v486 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v379 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22
v413 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v450 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
(ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
v337 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v121 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v314 (Ras_activated:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v485 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v378 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
v412 Ras_activated:GTP + Raf#P -> Raf:Ras:GTP k29 kd29
v30 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v122 cPP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b
(ErbB1:ErbB3)#P:GAP:Grb2 , endosomal membrane
v340 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v149 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
v377 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v484 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , plasma membrane
2(EGF:ErbB1)#P:GAP:(Shc#P) , endosomal membrane
v29 ErbB2:ErbB2#P + ATP -> ErbB2:ErbB2#P:ATP k122 kd122
(ErbB1:ErbB4)#P:GAP:Grb2 , endosomal membrane
v339 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v316 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v556 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v66 (ErbB1:ErbB4)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k4b kd4
v28 EGF:ErbB1:ErbB4 + ATP -> EGF:ErbB1:ErbB4:ATP k122 kd122
(EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive , plasma membrane
2(EGF:ErbB1)#P:GAP:(Shc#P) , plasma membrane
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) , endosomal membrane
v180 (ErbB4:ErbB2)#P:GAP:Shc -> (ErbB4:ErbB2)#P:GAP:Shc k6 kd6
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP , plasma membrane
v204 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
v67 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v88 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v555 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v65 (ErbB1:ErbB3)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k4b kd4
v205 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 , plasma membrane
2(EGF:ErbB1)#P:GAP:Shc , endosomal membrane
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P , plasma membrane
v87 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v554 (ErbB1:ErbB4)#P:GAP:Grb2 -> R_degraded k60b kd60
v64 (ErbB1:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k4b kd4
(ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) , endosomal membrane
2(EGF:ErbB1)#P:GAP:Shc , plasma membrane
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 , plasma membrane
v261 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v416 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v90 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v557 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v179 (ErbB3:ErbB2)#P:GAP:Shc ->(ErbB3:ErbB2)#P:GAP:Shc k6b kd6b
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 , plasma membrane
v260 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v415 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v89 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v653 RTK_Pase + 2(ErbB2)#P -> 2(ErbB2)#P:RTK_Pase k94 kd94
v857 2(EGF:ErbB1_h:ATP) + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k122 kd122
v85 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4
v600 (EGF:ErbB1:ErbB2) -> R_degraded k62b kd60b
v780 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
(ErbB3:ErbB2)#P:GAP:Shc , plasma membrane
v265 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v206 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8
v2 (ErbB2:ErbB3) + EGF -> (ErbB3:ErbB2)#P k1c kd1c
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 , plasma membrane
v652 RTK_Pase + 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P:RTK_Pase k94 kd94
v856 EGF:ErbB1:Inh::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k122 kd122
v84 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v150 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
v778 Pase9t + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)2:Gab1#P##:Pase9t k118 kd118
v526 2(EGF:ErbB1)#P:GAP:Grb2 -> R_degraded k60 kd60
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 , plasma membrane
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v779 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118
v207 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8
v1 EGF + ErbB1:ATP -> EGF:ErbB1:ATP k1 kd1
v264 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v640 PIP3 + AKT#P -> PIP3:AKT#P k69 kd69
v553 (ErbB1:ErbB3)#P:GAP:Grb2 -> R_degraded k60b kd60
v641 PDK1 + PIP3:AKT#P -> PIP3:AKT#P:PDK1 k70 kd70
v777 Pase9t + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1):Gab1#P##:Pase9t k118 kd118
v263 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive , plasma membrane
v208 ErbB1:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP , plasma membrane
2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP , plasma membrane
v525 2(EGF:ErbB1)#P:GAP -> R_degraded k60 kd60
v68 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
2(ErbB2)#P:GAP:(Shc#P):Grb2 , plasma membrane
v601 (EGF:ErbB1:ErbB3) -> R_degraded k62b kd60b
v209 ErbB3 + -> (HRG:ErbB3) k10b kd10
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos , plasma membrane
v262 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v524 2(EGF:ErbB1:ATP) -> R_degraded k60 kd60
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v317 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v447 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
v153 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v853 EGF:ErbB1_h:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh k2 kd2
v523 ErbB1:ATP -> R_degraded k60 kd60
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 , plasma membrane
v155 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5
v341 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
(ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) , endosomal membrane
v656 RTK_Pase + (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P:RTK_Pase k94 kd94
v522 Pase3 + (ERK#P)_i -> (ERK#P:Pase3)_i k58 kd58
v319 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v151 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v855 EGF:ErbB1:ATP::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k122 kd122
v655 RTK_Pase + (ErbB4:ErbB2)#P -> (ErbB2:ErbB4)#P:RTK_Pase k94 kd94
v449 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
v637 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k68 kd68b
v117 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b
v376 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b
2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
v598 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
(ErbB4:ErbB2)#P:GAP , endosomal membrane
v152 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v318 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
(EGF:ErbB1:ATP::EGF:ErbB1:Inh) , plasma membrane
v448 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37
v654 RTK_Pase + (ErbB3:ErbB2)#P -> (ErbB2:ErbB3)#P:RTK_Pase k94 kd94
v854 EGF:ErbB1_h:Inh + EGF:ErbB1:Inh -> EGF:ErbB1_h:Inh::EGF:ErbB1:Inh k2 kd2
v638 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k68 kd68b
v118 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b
v375 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b
(ErbB3:ErbB2)#P:GAP , endosomal membrane
v597 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
(ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP , plasma membrane
v781 Pase9t + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k118 kd118
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) , plasma membrane
v385 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
v407 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v37 (HRG:ErbB3:ErbB1) + ATP -> (HRG:ErbB3:ErbB1):ATP k122 kd122
(ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v127 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v308 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v444 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37
v408 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v386 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP , plasma membrane
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) , endosomal membrane
v309 Ras:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v126 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
(ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v445 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
v35 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v383 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23
2(EGF:ErbB1)#P:GAP:Grb2:Sos#P , plasma membrane
v310 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v144 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) , endosomal membrane
v382 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) , plasma membrane
v446 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37
v36 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k122 kd122
v384 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23
v143 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v92 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v311 Ras_activated:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP , plasma membrane
v59 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v549 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
2(ErbB2)#P:GAP:Grb2:Sos , plasma membrane
v256 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
(ErbB4:ErbB2)#P:GAP:Shc , endosomal membrane
v199 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8 kd8
v3 ErbB2:ErbB4 + EGF -> (ErbB4:ErbB2)#P k1d kd1d
v411 (Ras_activated:GTP)_i + (Raf#P)_i -> (Raf:Ras:GTP)_i k29 kd29
v33 2(ErbB2)#P:GAP:Grb2:Gab1 + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v548 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v93 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v60 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v550 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) , plasma membrane
2(ErbB2)#P:GAP:Grb2:Sos:cPP , plasma membrane
v4 EGF + ErbB1:Inh -> EGF:ErbB1:Inh k1 kd1
v198 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8
(ErbB3:ErbB2)#P:GAP:(Shc#P) , plasma membrane
v34 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122
v94 (ErbB3:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k4b kd4
v551 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
(ErbB1:ErbB2)#P:GAP:Grb2 , endosomal membrane
v409 Ras:GTP + Raf -> Raf:Ras:GTP k28 kd28
(ErbB3:ErbB2)#P:GAP:Shc , endosomal membrane
v185 (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P k7 kd7
v254 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17
v95 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
(ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , endosomal membrane
v552 (ErbB1:ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60
v200 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
v255 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v410 (Ras:GTP)_i + Raf -> (Raf:Ras:GTP)_i k28 kd28
v184 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k6b kd6b
2(ErbB2)#P:GAP:Grb2:cPP , plasma membrane
(ErbB4:ErbB2)#P:GAP:Shc , plasma membrane
v96 (ErbB4:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k4b kd4
v91 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4
v658 RTK_Pase + (EGF:ErbB1:ErbB3) -> (ErbB1:ErbB3)#P:RTK_Pase k95 kd95
v850 EGF:ErbB1:ATP + EGF:ErbB1_h:ATP -> EGF:ErbB1:ATP::EGF:ErbB1_h:ATP k2 kd2
v772 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117
(ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v7 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP)) k2 kd2
(ErbB3:ErbB2)#P:GAP:(Shc#P) , endosomal membrane
v201 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
v258 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
2(ErbB2)2:Gab1#P##:Pase9t , plasma membrane
v520 ERK + Pase3 -> (ERK#P:Pase3)_i k57 kd57
v773 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117
v605 (HRG:ErbB3):ErbB2) -> R_degraded k62b kd60b
v657 RTK_Pase + (EGF:ErbB1:ErbB2) -> (ErbB1:ErbB2)#P:RTK_Pase k95 kd95
v659 RTK_Pase + (EGF:ErbB1:ErbB4) -> (ErbB1:ErbB4)#P:RTK_Pase k95 kd95
v851 EGF:ErbB1:Inh + EGF:ErbB1_h:ATP -> EGF:ErbB1:Inh::EGF:ErbB1_h:ATP k2 kd2
(ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 , plasma membrane
v181 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k6b kd6b
2(EGF:ErbB1):Gab1#P##:Pase9t , plasma membrane
v259 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v606 (HRG:ErbB4):ErbB2) -> R_degraded k62b kd60b
v521 Pase3 + ERK#P -> ERK#P:Pase3 k58 kd58
v774 Pase9t + ErbB3/4:ErbB2:Gab1#P## -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k117 kd117
v852 EGF:ErbB1_h:ATP + EGF:ErbB1_h:ATP -> 2(EGF:ErbB1_h:ATP) k2 kd2
v62 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) , plasma membrane
v203 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8
v518 ERK#P + Pase3 -> ERK#P#P:Pase3 k57 kd57
v5 EGF:ErbB1:ATP + EGF:ErbB1:Inh -> (EGF:ErbB1:ErbB1):Inh k2 kd2
v61 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v63 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP , plasma membrane
v519 ERK + Pase3 -> ERK#P:Pase3 k57 kd57
v257 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v202 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
v6 EGF:ErbB1:Inh + EGF:ErbB1:Inh -> 2(EGF:ErbB1:Inh) k2 kd2
2(EGF:ErbB1)#P:GAP:Grb2:Sos , plasma membrane
v148 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b
v123 cPP + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:cPP k5 kd5b
v602 (EGF:ErbB1:ErbB4) -> R_degraded k62b kd60b
v147 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v517 (ERK#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k57 kd57
v660 RTK_Pase + 2(EGF:ErbB1:ATP) -> 2(EGF:ErbB1)#P:RTK_Pase k95 kd95
v146 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v312 (Ras_activated:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v125 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v828 ErbB1 + ATP -> ErbB1:ATP k122 kd122
v603 (HRG:ErbB3:ErbB1) -> R_degraded k62b kd60b
v775 Pase9t + ErbB1:ErbB:Gab1#P## -> ErbB1:ErbB:Gab1#P##:Pase9t k117 kd117
v381 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
v829 ErbB1_h + ATP -> ErbB1_h:ATP k122 kd122
v661 RTK_Pase + 2(ErbB2) -> 2(ErbB2)#P:RTK_Pase k95 kd95
v313 Ras_activated:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v145 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v124 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v776 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k117 kd117
v604 (HRG:ErbB4:ErbB1) -> R_degraded k62b kd60b