574479
units: dimensionless
value: 5.12
type: LocalParameter

metaid F6P
has only substance units: false
initial concentration: 0.28
boundary condition: false
initial amount: NaN
is: SBO:0000247
in compartment: metaid cytoplasm
is: CHEBI:15946
type: Species
constant: false
name: Fructose 6 Phosphate
is: C05345

574592
units: 905463
value: 3458.0
name: VmPPIr
type: LocalParameter

906570
stoichiometry: 1.0
species: metaid Ribulose5P
type: SpeciesReference

906702
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

906196
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

574501
units: 905511
value: 0.3
type: LocalParameter

574532
units: 905511
value: 0.003
type: LocalParameter

574511
units: 905511
value: 0.93
type: LocalParameter

metaid PYR
name: Pyruvate
type: Species
initial concentration: 3.36
constant: false
is: C00022
initial amount: NaN
is: SBO:0000247
boundary condition: false
in compartment: metaid cytoplasm
has only substance units: false
is: CHEBI:15361

905968
stoichiometry: 1.0
species: metaid P2G
type: SpeciesReference

574489
units: dimensionless
value: 0.397
type: LocalParameter

574619
units: 905511
value: 0.09
name: KmEry4P
type: LocalParameter

574572
units: 905511
value: 1.27
name: KmGA3P
type: LocalParameter

574609
units: 905463
value: 10.0
name: VmTransaldr
type: LocalParameter

metaid vG3PDH
reactant: 905764
reactant: 905776
fast: false
is: SBO:0000200
type: Reaction
product: 905800
name: Glycerol 3-phosphate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.8
product: 905788
kinetic law: 905812
reversible: true

574552
units: 905511
value: 1.5
type: LocalParameter

906220
stoichiometry: 1.0
species: metaid P
type: SpeciesReference

574389
kinetic law: 906558
is version of: R01641
product: 906534
product: 906546
is version of: GO:0004802
reversible: true
name: vTransk1
fast: false
reactant: 906522
reactant: 906509
is: SBO:0000182
type: Reaction

905451
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

905427
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

905908
stoichiometry: 1.0
species: metaid P
type: SpeciesReference

574510
units: 905511
value: 0.023
type: LocalParameter

metaid P3G
initial concentration: 0.1
initial amount: NaN
has only substance units: false
is: CHEBI:17794
type: Species
in compartment: metaid cytoplasm
is: SBO:0000247
name: 3-phosphoglycerate
is: C00197
boundary condition: false
constant: false

574593
units: 905511
value: 1.6
name: KmRibu5P
type: LocalParameter

906485
stoichiometry: 1.0
species: metaid Ribose5P
type: SpeciesReference

906606
stoichiometry: 1.0
species: metaid Seduhept7P
type: SpeciesReference

905656
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

metaid extracellular
is: GO:0005576
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

metaid D6PGluconate
type: Species
boundary condition: false
in compartment: metaid cytoplasm
name: 6-phosphogluconate
constant: false
has only substance units: false
is: CHEBI:16863
initial amount: NaN
initial concentration: 0.1
is: SBO:0000247

metaid vPGM
is: R01518
name: Phosphoglycerate mutase
kinetic law: 905956
is: SBO:0000377
product: 905944
is homolog to: REACT 576
type: Reaction
is: http://identifiers.org/ec-code/5.4.2.1
reversible: true
reactant: 905932
fast: false

574573
units: 905511
value: 1.23
name: KmDHAP
type: LocalParameter

metaid vATP
kinetic law: 906244
is version of: GO:0016887
reversible: true
type: Reaction
is: SBO:0000376
reactant: 906220
is version of: http://identifiers.org/ec-code/3.6.1.3
product: 906232
name: ATPase activity
fast: false

574491
units: dimensionless
value: 0.0845
type: LocalParameter

906630
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

574388
name: vPPI
type: Reaction
product: 906485
fast: false
reactant: 906473
is: SBO:0000377
kinetic law: 906497
reversible: true
is version of: GO:0004751
is version of: R01056

574553
units: 905463
value: 174.194
type: LocalParameter

metaid Erythrose4P
type: Species
has only substance units: false
constant: false
name: erythrose 4-phosphate
is: SBO:0000247
initial amount: NaN
in compartment: metaid cytoplasm
is: CHEBI:48153
boundary condition: false
initial concentration: 0.0

905848
stoichiometry: 1.0
species: metaid BPG
type: SpeciesReference

574477
units: 905511
value: 0.3
type: LocalParameter

574627
units: 905511
value: 1.1918
name: KmGLTGLCo
type: LocalParameter

574530
units: 905511
value: 0.2
type: LocalParameter

574590
units: 905463
value: 3458.0
name: VmPPIf
type: LocalParameter

574580
units: 905511
value: 0.017
name: KiNADPH
type: LocalParameter

906184
stoichiometry: 1.0
species: metaid ETOH
type: SpeciesReference

905740
stoichiometry: 1.0
species: metaid GA3P
type: SpeciesReference

metaid P
has only substance units: false
initial amount: NaN
in compartment: metaid cytoplasm
has part: C00008
initial concentration: 5.0
name: High energy phosphates
type: Species
has part: CHEBI:15422
is: SBO:0000247
has part: CHEBI:16761
has part: C00002
constant: false
boundary condition: false

906642
stoichiometry: 1.0
species: metaid Erythrose4P
type: SpeciesReference

574520
units: 905511
value: 0.09
type: LocalParameter

BIOMD0000000247
reaction: metaid vSUC
species: metaid F6P
species: metaid Erythrose4P
is: MODEL1003300000
species: metaid GLCo
reaction: metaid vENO
species: metaid PEP
reaction: metaid vALD
reaction: metaid vPFK
parameter: metaid SUMAXP
reaction: 574390
parameter: 574632
species: metaid G6P
species: metaid NAD
reaction: metaid vPGM
species: metaid P3G
species: metaid Ribulose5P
name: Ralser2007_Carbohydrate_Rerouting_ROS
species: metaid Xyl5P
has version: sce00030
has version: GO:0006739
units def: 905511
has version: sce00010
species: metaid GLCi
species: metaid NADH
compartment: metaid extracellular
reaction: 574386
is version of: GO:0034599
reaction: 574393
species: metaid NADPH
units def: 905463
reaction: metaid vPYK
reaction: metaid vATP
species: metaid Seduhept7P
curated: true
area units: metaid_0000005
species: metaid DHAP
species: metaid F26BP
reaction: metaid vPGI
species: metaid D6PGluconate
species: metaid D6PGluconoLactone
volume units: 845199
parameter: 574633
units def: 905439
has version: GO:0006096
species: metaid Ribose5P
reaction: 574389
reaction: 574391
units def: 905415
parameter: 574634
notes: This is the model with unfitted parameters described in the article Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach and Sylvia Krobitsch, J Biol 2007 6(4):10; PMID: 18154684 , doi: 10.1186/jbiol61 Abstract: BACKGROUND: Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role. RESULTS: We recently discovered that yeast cells with reduced activity of the key glycolytic enzyme triosephosphate isomerase exhibit an increased resistance to the thiol-oxidizing reagent diamide. Here we show that this phenotype is conserved in Caenorhabditis elegans and that the underlying mechanism is based on a redirection of the metabolic flux from glycolysis to the pentose phosphate pathway, altering the redox equilibrium of the cytoplasmic NADP(H) pool. Remarkably, another key glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), is known to be inactivated in response to various oxidant treatments, and we show that this provokes a similar redirection of the metabolic flux. CONCLUSION: The naturally occurring inactivation of GAPDH functions as a metabolic switch for rerouting the carbohydrate flux to counteract oxidative stress. As a consequence, altering the homoeostasis of cytoplasmic metabolites is a fundamental mechanism for balancing the redox state of eukaryotic cells under stress conditions. Different realtive enzyme velocities can be simulated by varying the parameters k_rel_TPI and k_rel_GAPDH . This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein …
reaction: 574394
reaction: metaid vPGK
species: metaid P
species: metaid ETOH
length unit: length
type: SBMLModel
reaction: metaid vG3PDH
species: metaid GA3P
species: metaid CO2
reaction: metaid vADH
reaction: 574384
reaction: metaid vGLT
reaction: metaid vGLK
species: metaid NADP
has version: GO:0006098
reaction: metaid vGAPDH
species: 574230
compartment: metaid cytoplasm
reaction: metaid vPDC
species: metaid SUCC
reaction: 574383
species: metaid PYR
substance units: 905415
species: metaid GLY
species: metaid P2G
occurs in: http://identifiers.org/taxonomy/4932
time units: 905439
species: metaid F16P
rule: 574630

574490
units: 905511
value: 0.111
type: LocalParameter

574513
units: 905463
value: 6549.68
type: LocalParameter

574540
units: 905463
value: 365.806
type: LocalParameter

metaid NAD
constant: false
type: Species
is: CHEBI:15846
initial concentration: 1.2
initial amount: NaN
has only substance units: false
boundary condition: false
in compartment: metaid cytoplasm
is: SBO:0000247
is: C00003
name: NAD

574607
units: 905511
value: 1.5
name: KmXyl
type: LocalParameter

574550
units: dimensionless
value: 6500.0
type: LocalParameter

574570
units: 905548
value: 39.5
type: LocalParameter

574628
units: 905511
value: 1.1918
name: KmGLTGLCi
type: LocalParameter

906124
stoichiometry: 3.0
species: metaid NADH
type: SpeciesReference

906473
stoichiometry: 1.0
species: metaid Ribulose5P
type: SpeciesReference

905463
unit: 905499
unit: 905487
unit: 905475
name: mMpermin
type: SBMLUnitsDef

metaid PEP
boundary condition: false
initial amount: NaN
constant: false
name: Phosphoenolpyruvate
is: CHEBI:18021
has only substance units: false
type: Species
initial concentration: 0.1
in compartment: metaid cytoplasm
is: C00074
is: SBO:0000247

metaid SUCC
is: SBO:0000247
constant: false
boundary condition: true
name: Succinate
type: Species
has only substance units: false
is: CHEBI:30031
initial concentration: 0.1
initial amount: NaN
in compartment: metaid extracellular

905415
unit: 905427
name: millimole
type: SBMLUnitsDef

574230
is: SBO:0000291
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid cytoplasm
name: X
type: Species

574512
units: 905511
value: 1.0
type: LocalParameter

metaid GA3P
type: Species
has only substance units: false
constant: false
name: glyceraldehyde 3-phosphate
is: CHEBI:17138
is: SBO:0000247
initial concentration: 0.05
boundary condition: false
in compartment: metaid cytoplasm
initial amount: NaN

574571
units: dimensionless
value: 0.45
type: LocalParameter

metaid vGLT
kinetic law: 906788
fast: false
name: Glucose transport
is: SBO:0000185
reactant: 906763
reversible: true
is version of: GO:0046323
type: Reaction
product: 906776
is homolog to: REACT 2092

metaid vPGK
product: 905896
is homolog to: REACT 1771
reactant: 905884
is: SBO:0000216
product: 905908
reversible: true
kinetic law: 905920
type: Reaction
name: Phosphoglycerate kinase
is: http://identifiers.org/ec-code/2.7.2.3
is: R01512
fast: false

906618
stoichiometry: 1.0
species: metaid GA3P
type: SpeciesReference

905668
stoichiometry: 1.0
species: metaid P
type: SpeciesReference

906546
stoichiometry: 1.0
species: metaid Seduhept7P
type: SpeciesReference

574561
units: 905511
value: 17.0
type: LocalParameter

metaid vPFK
kinetic law: 905704
reactant: 905668
product: 905680
is: SBO:0000216
is: http://identifiers.org/ec-code/2.7.1.11
type: Reaction
reactant: 905656
modifier: 905692
reversible: true
name: Phosphofructokinase
is: R00756
is homolog to: REACT 736
fast: false

574551
units: 905511
value: 21.0
type: LocalParameter

metaid ETOH
initial amount: NaN
initial concentration: 50.0
is: SBO:0000247
name: Ethanol
is: C00469
constant: false
boundary condition: true
is: CHEBI:16236
type: Species
has only substance units: false
in compartment: metaid extracellular

574608
units: 905463
value: 55.0
name: VmTransaldf
type: LocalParameter

574596
units: 905463
value: 2.0
name: VmTransk1r
type: LocalParameter

905499
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

906437
stoichiometry: 1.0
species: metaid NADPH
type: SpeciesReference

574582
units: 905463
value: 4.0
name: Vm6PGL
type: LocalParameter

906726
stoichiometry: 1.0
species: metaid NADPH
type: SpeciesReference

906172
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

574505
units: 905463
value: 70.15
type: LocalParameter

574385
type: Reaction
is version of: R02035
fast: false
is version of: GO:0017057
reactant: 906364
name: v6PGL
is: SBO:0000376
kinetic law: 906388
reversible: false
product: 906376

906076
stoichiometry: 1.0
species: metaid CO2
type: SpeciesReference

574605
units: 905463
value: 1039.0
name: VmR5PIr
type: LocalParameter

905944
stoichiometry: 1.0
species: metaid P2G
type: SpeciesReference

574556
units: 905548
value: 21.4
type: LocalParameter

574615
units: 905463
value: 3.2
name: VmTransk2F
type: LocalParameter

574542
units: 905511
value: 0.04
type: LocalParameter

905560
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid GLCi
in compartment: metaid cytoplasm
initial concentration: 0.087
name: Glucose in Cytosol
is: SBO:0000247
constant: false
initial amount: NaN
is: C00293
is: CHEBI:17234
boundary condition: false
has only substance units: false
type: Species

574519
units: 905511
value: 0.21
type: LocalParameter

574515
units: 905511
value: 0.06
type: LocalParameter

metaid Seduhept7P
initial concentration: 0.1
name: sedoheptulose 7-phosphate
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:15721
is: SBO:0000247
in compartment: metaid cytoplasm
has only substance units: false
type: Species

574597
units: 905511
value: 0.1
name: KmRibose5P
type: LocalParameter

906534
stoichiometry: 1.0
species: metaid GA3P
type: SpeciesReference

905632
stoichiometry: 1.0
species: metaid F6P
type: SpeciesReference

905680
stoichiometry: 1.0
species: metaid F16P
type: SpeciesReference

574583
units: 905511
value: 0.8
name: Km6PGL
type: LocalParameter

574600
units: 905511
value: 0.1
name: KmGA3P
type: LocalParameter

metaid vSUC
reactant: 906100
is version of: GO:0006105
reversible: true
reactant: 906112
name: Succinate synthesis
product: 906136
product: 906124
is: SBO:0000205
kinetic law: 906148
fast: false
type: Reaction

905475
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

574606
units: 905511
value: 1.5
name: KmRibu5P
type: LocalParameter

574384
fast: false
name: vG6PDH
product: 906328
is version of: R00835
reactant: 906292
kinetic law: 906352
type: Reaction
reversible: false
modifier: 906340
is version of: http://identifiers.org/ec-code/1.1.1.49
is version of: GO:0004345
product: 906316
reactant: 906304
is: SBO:0000200

574504
units: 905511
value: 10.0
type: LocalParameter

574543
units: dimensionless
value: 6.7
type: LocalParameter

574518
units: 905463
value: 1184.52
type: LocalParameter

574514
units: 905511
value: 0.0098
type: LocalParameter

574616
units: 905463
value: 43.0
name: VmTransk2r
type: LocalParameter

574594
units: 905511
value: 1.6
name: KmRibo5P
type: LocalParameter

906232
stoichiometry: 1.0
species: 574230
type: SpeciesReference

metaid D6PGluconoLactone
boundary condition: false
in compartment: metaid cytoplasm
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16938
initial amount: NaN
initial concentration: 0.1
constant: false
name: D-6-phosphoglucono-delta-lactone

574584
units: 905463
value: 4.0
name: VmGluDH
type: LocalParameter

574480
units: 905463
value: 182.903
type: LocalParameter

metaid NADP
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:18009
initial amount: NaN
constant: false
in compartment: metaid cytoplasm
name: NADP+
is: SBO:0000247
initial concentration: 0.4

574603
units: 905463
value: 1039.0
name: VmR5PIf
type: LocalParameter

574554
units: dimensionless
value: 1.9
type: LocalParameter

574601
units: 905511
value: 0.15
name: KmSeduhept
type: LocalParameter

905572
stoichiometry: 1.0
species: metaid GLCi
type: SpeciesReference

905896
stoichiometry: 1.0
species: metaid P3G
type: SpeciesReference

906738
stoichiometry: 1.0
species: metaid NADP
type: SpeciesReference

574503
units: 905511
value: 2.0
type: LocalParameter

906160
stoichiometry: 1.0
species: metaid ACE
type: SpeciesReference

906582
stoichiometry: 1.0
species: metaid Xyl5P
type: SpeciesReference

574617
units: 905511
value: 0.16
name: KmXyl5P
type: LocalParameter

906136
stoichiometry: 1.0
species: metaid SUCC
type: SpeciesReference

574517
units: dimensionless
value: 0.045
type: LocalParameter

574544
units: 905511
value: 0.5
type: LocalParameter

905932
stoichiometry: 1.0
species: metaid P3G
type: SpeciesReference

metaid vALD
product: 905740
is homolog to: REACT 1602
reactant: 905716
type: Reaction
is: SBO:0000182
fast: false
product: 905728
is: http://identifiers.org/ec-code/4.1.2.13
kinetic law: 905752
reversible: true
is: R01070
name: Aldolase

574595
units: 905463
value: 4.0
name: VmTransk1f
type: LocalParameter

906522
stoichiometry: 1.0
species: metaid Xyl5P
type: SpeciesReference

metaid Ribose5P
is: CHEBI:17797
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 0.1
in compartment: metaid cytoplasm
constant: false
initial amount: NaN
name: ribose 5-phosphate
has only substance units: false

574585
units: 905511
value: 0.02
name: KmGluconate
type: LocalParameter

574555
units: 905511
value: 4.33
type: LocalParameter

574502
units: 905511
value: 2.4
type: LocalParameter

905980
stoichiometry: 1.0
species: metaid PEP
type: SpeciesReference

574386
fast: false
name: vGluDH
is version of: R01528
type: Reaction
product: 906437
is version of: GO:0004616
reactant: 906413
is: SBO:0000200
reversible: false
product: 906425
modifier: 906449
kinetic law: 906461
reactant: 906400

metaid G6P
name: Glucose 6 Phosphate
initial amount: NaN
boundary condition: false
in compartment: metaid cytoplasm
type: Species
constant: false
has only substance units: false
initial concentration: 1.39
is: C00668
is: CHEBI:17665
is: SBO:0000247

metaid cytoplasm
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

905439
unit: 905451
name: minute
type: SBMLUnitsDef

574545
units: 905463
value: 1088.71
type: LocalParameter

574431
units: 905511
value: 0.23
type: LocalParameter

metaid P2G
is: SBO:0000247
boundary condition: false
name: 2-phosphoglycerate
initial amount: NaN
in compartment: metaid cytoplasm
type: Species
has only substance units: false
is: CHEBI:17835
constant: false
initial concentration: 0.1
is: C00631

574506
units: dimensionless
value: 4300.0
type: LocalParameter

574624
units: 905463
value: 97.264
name: VmGLT
type: LocalParameter

574614
units: 905511
value: 0.018
name: KmEry4P
type: LocalParameter

574567
units: 905511
value: 1.11
type: LocalParameter

906763
stoichiometry: 1.0
species: metaid GLCo
type: SpeciesReference

906328
stoichiometry: 1.0
species: metaid NADPH
type: SpeciesReference

metaid vGAPDH
is: http://identifiers.org/ec-code/1.2.1.12
reactant: 905836
fast: false
is homolog to: REACT 1847
product: 905860
product: 905848
is: SBO:0000200
reactant: 905824
type: Reaction
name: Glyceraldehyde 3-phosphate dehydrogenase
kinetic law: 905872
reversible: true
is: R01061

906100
stoichiometry: 2.0
species: metaid ACE
type: SpeciesReference

metaid BPG
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 0.1
is: C00236
is: CHEBI:16001
boundary condition: false
has only substance units: false
name: 1,3-bisphosphoglycerate
in compartment: metaid cytoplasm

574634
constant: false
units: dimensionless
value: NaN
name: ratio_NADPH_NADP
type: Parameter

574546
units: 905511
value: 0.14
type: LocalParameter

574507
units: dimensionless
value: 0.045
type: LocalParameter

906678
stoichiometry: 1.0
species: metaid Erythrose4P
type: SpeciesReference

574527
units: dimensionless
value: 0.45
type: LocalParameter

905728
stoichiometry: 1.0
species: metaid DHAP
type: SpeciesReference

906064
stoichiometry: 1.0
species: metaid ACE
type: SpeciesReference

905584
stoichiometry: 1.0
species: metaid P
type: SpeciesReference

905884
stoichiometry: 1.0
species: metaid BPG
type: SpeciesReference

905800
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

574613
units: 905511
value: 0.32
name: KmF6P
type: LocalParameter

574394
kinetic law: 906751
product: 906738
reactant: 906726
is version of: GO:0070995
is: SBO:0000201
fast: false
reversible: false
name: vNADPH
type: Reaction

574566
units: 905511
value: 0.031
type: LocalParameter

574499
units: dimensionless
value: 0.069
type: LocalParameter

574633
constant: true
units: dimensionless
value: 1.0
name: k_rel_GAPDH
type: Parameter

metaid SUMAXP
has part: CHEBI:16761
has part: C00008
has part: CHEBI:15422
name: sum of AXP conc
value: 4.1
has part: CHEBI:16027
constant: true
has part: C00020
has part: C00002
type: Parameter

metaid NADPH
is: CHEBI:16474
initial concentration: 1.6
initial amount: NaN
in compartment: metaid cytoplasm
type: Species
boundary condition: false
has only substance units: false
name: NADPH
is: SBO:0000247
constant: false

574586
units: 905511
value: 0.03
name: KmNADP
type: LocalParameter

metaid vPYK
is: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
is: R00200
product: 906016
is: SBO:0000216
reversible: true
fast: false
is homolog to: REACT 1911
reactant: 906004
product: 906028
name: Pyruvate kinase
kinetic law: 906040

574481
units: dimensionless
value: 0.45
type: LocalParameter

906425
stoichiometry: 1.0
species: metaid Ribulose5P
type: SpeciesReference

906004
stoichiometry: 1.0
species: metaid PEP
type: SpeciesReference

574401
units: 905463
value: 226.452
type: LocalParameter

905523
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

574547
units: 905511
value: 0.53
type: LocalParameter

905487
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid CO2
constant: false
boundary condition: true
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16526
is: C00011
name: CO2
in compartment: metaid extracellular

574626
units: 905511
value: 1.0
name: KeqGLT
type: LocalParameter

574383
type: Reaction
reversible: true
reactant: 906256
kinetic law: 906280
name: vTPI
is version of: R01015
is version of: GO:0004807
product: 906268
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000377
fast: false

574404
units: dimensionless
value: 3800.0
type: LocalParameter

574528
units: 905511
value: 0.3
type: LocalParameter

574632
constant: true
units: dimensionless
value: 1.0
name: k_rel_TPI
type: Parameter

574498
units: dimensionless
value: 0.045
type: LocalParameter

574538
units: 905511
value: 0.08
type: LocalParameter

574393
reactant: 906678
fast: false
name: vTransk2
reactant: 906666
is version of: GO:0004802
product: 906690
reversible: true
type: Reaction
kinetic law: 906714
product: 906702
is: SBO:0000182
is version of: R01830

574612
units: 905511
value: 0.18
name: KmSeduhept
type: LocalParameter

metaid GLCo
boundary condition: true
has only substance units: false
in compartment: metaid extracellular
initial amount: NaN
is: C00293
initial concentration: 50.0
constant: false
is: SBO:0000247
is: CHEBI:17234
name: Extracellular Glucose
type: Species

906690
stoichiometry: 1.0
species: metaid GA3P
type: SpeciesReference

574569
units: 905511
value: 90.0
type: LocalParameter

metaid GLY
is: SBO:0000247
is: C00116
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: CHEBI:17754
has only substance units: false
in compartment: metaid extracellular
name: Glycerol
initial concentration: 0.15

574558
units: 905463
value: 810.0
type: LocalParameter

574548
units: dimensionless
value: 0.45
type: LocalParameter

574484
units: 905511
value: 0.71
type: LocalParameter

906112
stoichiometry: 3.0
species: metaid NAD
type: SpeciesReference

905620
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

905596
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

574578
units: 905511
value: 0.02
name: KmNADP
type: LocalParameter

574509
units: 905511
value: 0.4
type: LocalParameter

906052
stoichiometry: 1.0
species: metaid PYR
type: SpeciesReference

574529
units: 905511
value: 0.53
type: LocalParameter

906776
stoichiometry: 1.0
species: metaid GLCi
type: SpeciesReference

905548
unit: 905560
name: permin
type: SBMLUnitsDef

metaid Ribulose5P
name: ribulose 5-phosphate
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:17363
constant: false
initial concentration: 0.1
in compartment: metaid cytoplasm
boundary condition: false

574403
units: dimensionless
value: 0.45
type: LocalParameter

metaid vPDC
product: 906076
kinetic law: 906088
type: Reaction
is: R00224
fast: false
reactant: 906052
product: 906064
name: Pyruvate decarboxylase
is: SBO:0000399
is: http://identifiers.org/ec-code/4.1.1.1
reversible: true

574444
units: 905463
value: 339.677
type: LocalParameter

905716
stoichiometry: 1.0
species: metaid F16P
type: SpeciesReference

metaid vGLK
kinetic law: 905608
name: Hexokinase
reactant: 905584
is homolog to: REACT 1318
reactant: 905572
fast: false
reversible: true
type: Reaction
product: 905596
is: R00299
is: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000216

905788
stoichiometry: 1.0
species: metaid GLY
type: SpeciesReference

574497
units: 905463
value: 322.258
type: LocalParameter

574568
units: 905511
value: 1.1
type: LocalParameter

metaid F16P
in compartment: metaid cytoplasm
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16905
type: Species
is: C00354
has only substance units: false
initial concentration: 0.1
is: SBO:0000247
name: Fructose-1,6 bisphosphate

905535
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

906413
stoichiometry: 1.0
species: metaid NADP
type: SpeciesReference

574559
units: 905511
value: 0.92
type: LocalParameter

574588
units: 905511
value: 0.03
name: KiNADPH
type: LocalParameter

574598
units: 905511
value: 0.15
name: KmXyl5P
type: LocalParameter

574483
units: 905511
value: 0.1
type: LocalParameter

574391
fast: false
product: 906642
reactant: 906606
is version of: GO:0004801
reversible: true
kinetic law: 906654
type: Reaction
is version of: R01827
product: 906630
is: SBO:0000182
name: vTransald
reactant: 906618

574496
units: dimensionless
value: 3.0
type: LocalParameter

905860
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

metaid F26BP
in compartment: metaid cytoplasm
boundary condition: true
initial amount: NaN
is: CHEBI:28602
is: SBO:0000247
is: C00665
has only substance units: false
initial concentration: 0.02
type: Species
name: F2,6P
constant: false

574563
units: 905511
value: 0.17
type: LocalParameter

574445
units: 905511
value: 1.4
type: LocalParameter

906400
stoichiometry: 1.0
species: metaid D6PGluconate
type: SpeciesReference

574406
units: 905511
value: 0.08
type: LocalParameter

574577
units: 905511
value: 0.04
name: KmG6P
type: LocalParameter

metaid vADH
type: Reaction
reactant: 906172
is version of: R00746
is: SBO:0000200
name: Alcohol dehydrogenase
is homolog to: REACT 799
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: 906208
reversible: true
reactant: 906160
fast: false
product: 906196
product: 906184

574522
units: dimensionless
value: 0.005
name: KeqGAPDH
type: LocalParameter

574620
units: 905511
value: 1.1
name: KmF6P
type: LocalParameter

906509
stoichiometry: 1.0
species: metaid Ribose5P
type: SpeciesReference

574486
units: dimensionless
value: 0.0174
type: LocalParameter

906304
stoichiometry: 1.0
species: metaid NADP
type: SpeciesReference

574610
units: 905511
value: 0.22
name: KmGA3P
type: LocalParameter

574495
units: 905511
value: 0.65
type: LocalParameter

574537
units: dimensionless
value: 0.19
type: LocalParameter

574390
kinetic law: 906594
product: 906582
reactant: 906570
is: SBO:0000377
fast: false
reversible: true
name: vR5PI
type: Reaction

574446
units: dimensionless
value: 0.314
type: LocalParameter

906376
stoichiometry: 1.0
species: metaid D6PGluconate
type: SpeciesReference

574562
units: dimensionless
value: 6.9E-5
type: LocalParameter

574405
units: 905511
value: 0.15
type: LocalParameter

906028
stoichiometry: 1.0
species: metaid P
type: SpeciesReference

574576
units: 905463
value: 4.0
name: VmG6PDH
type: LocalParameter

905776
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

906256
stoichiometry: 1.0
species: metaid GA3P
type: SpeciesReference

574485
units: dimensionless
value: 0.66
type: LocalParameter

metaid Xyl5P
in compartment: metaid cytoplasm
initial amount: NaN
constant: false
is: CHEBI:16332
initial concentration: 0.1
type: Species
boundary condition: false
is: SBO:0000247
name: xylulose 5-phosphate
has only substance units: false

905824
stoichiometry: 1.0
species: metaid GA3P
type: SpeciesReference

906268
stoichiometry: 1.0
species: metaid DHAP
type: SpeciesReference

574494
units: dimensionless
value: 100.0
type: LocalParameter

574408
units: 905511
value: 30.0
type: LocalParameter

574524
units: 905463
value: 1306.45
type: LocalParameter

574575
units: 905463
value: 555.0
name: VmGA3P
type: LocalParameter

906292
stoichiometry: 1.0
species: metaid G6P
type: SpeciesReference

metaid vPGI
product: 905632
reversible: true
is: SBO:0000377
reactant: 905620
name: Glucose-6-phosphate isomerase
is: R00771
fast: false
is: http://identifiers.org/ec-code/5.3.1.9
type: Reaction
kinetic law: 905644
is homolog to: REACT 116

metaid NADH
is: C00004
type: Species
initial concentration: 0.39
in compartment: metaid cytoplasm
is: CHEBI:16908
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: NADH
boundary condition: false

574622
units: 905548
value: 2.0
name: kNADPH
type: LocalParameter

906316
stoichiometry: 1.0
species: metaid D6PGluconoLactone
type: SpeciesReference

574488
units: 905511
value: 6.82E-4
type: LocalParameter

574534
units: 905463
value: 2525.81
type: LocalParameter

metaid ACE
constant: false
name: Acetaldehyde
in compartment: metaid cytoplasm
initial concentration: 0.04
is: CHEBI:15343
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: C00084

metaid DHAP
name: dihydroxyacetone phosphate
type: Species
constant: false
in compartment: metaid cytoplasm
initial amount: NaN
is: SBO:0000247
is: CHEBI:16108
has only substance units: false
initial concentration: 1.0
boundary condition: false

906016
stoichiometry: 1.0
species: metaid PYR
type: SpeciesReference

905511
unit: 905535
unit: 905523
name: mM
type: SBMLUnitsDef

574535
units: 905511
value: 1.2
type: LocalParameter

metaid vENO
is: R00658
is: SBO:0000211
reactant: 905968
kinetic law: 905992
product: 905980
reversible: true
fast: false
is: http://identifiers.org/ec-code/4.2.1.11
is homolog to: REACT 1400
name: Enolase
type: Reaction

574564
units: 905511
value: 0.11
type: LocalParameter

574525
units: dimensionless
value: 3200.0
type: LocalParameter

574493
units: 905511
value: 0.0995
type: LocalParameter

906364
stoichiometry: 1.0
species: metaid D6PGluconoLactone
type: SpeciesReference

574574
units: 905463
value: 10900.0
name: VmDHAP
type: LocalParameter

574621
units: 905511
value: 2.1
name: KmGA3P
type: LocalParameter

905764
stoichiometry: 1.0
species: metaid DHAP
type: SpeciesReference

905836
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

906666
stoichiometry: 1.0
species: metaid Xyl5P
type: SpeciesReference

orgname: Stellenbosh University

W3 CDTF: Wed Apr 11 12:09:00 BST 2007

given: Jacky L
family: Snoep

W3 CDTF: Tue May 15 22:59:06 BST 2012

given: Kieran
family: Smallbone

ORG:
  orgname: University of Manchester