782314
stoichiometry: 1.0
species: metaid_0000214
type: SpeciesReference

metaid_0000221
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: OAA
has only substance units: true
is version of: C00036
in compartment: metaid_0000209
initial concentration: NaN
is version of: CHEBI:30744
initial amount: 0.050535354

metaid_0000135
constant: true
value: 2.31
name: g_acs_n
type: Parameter

metaid_0000169
constant: true
value: 8.2E-7
name: g_pfkA_vcra_unbound
type: Parameter

metaid_0000201
constant: false
value: 0.0
name: k_bm_G6P
type: Parameter

metaid_0000189
constant: true
value: 0.108
name: bm_ACT_ACoA
type: Parameter

metaid_0000115
constant: true
value: 100.0
name: tf_PdhR_scale
type: Parameter

metaid_0000294
kinetic law: 782955
modifier: 782943
modifier: 782931
product: 782919
reactant: 782907
fast: false
reversible: false
name: e_Icd
type: Reaction

metaid_0000220
in compartment: metaid_0000209
is version of: C00497
has only substance units: true
initial concentration: NaN
name: MAL
is version of: CHEBI:30796
constant: false
initial amount: 3.278779135
boundary condition: false
is: SBO:0000247
type: Species

metaid_0000136
constant: true
value: 0.0047
name: g_acs_Kcrp
type: Parameter

786097
stoichiometry: 1.0
species: metaid_0000255
type: SpeciesReference

metaid_0000200
constant: false
value: 0.0
name: k_bm_AKG
type: Parameter

metaid_0000116
constant: true
value: 0.164
name: tf_PdhR_kpyr
type: Parameter

metaid_0000295
kinetic law: 783004
modifier: 782992
product: 782979
reactant: 782967
fast: false
reversible: false
name: e_Mdh
type: Reaction

786535
stoichiometry: 1.0
species: metaid_0000221
type: SpeciesReference

786243
stoichiometry: 1.0
species: metaid_0000215
type: SpeciesReference

metaid_0000137
constant: true
value: 0.0
name: g_akg2mal_vcrp_unbound
type: Parameter

781682
stoichiometry: 1.0
species: metaid_0000223
type: SpeciesReference

metaid_0000380
unit: 781378
name: volume
type: SBMLUnitsDef

786025
stoichiometry: 1.0
species: metaid_0000246
type: SpeciesReference

metaid_0000223
type: Species
is version of: C00197
name: PG3
has only substance units: true
initial amount: 5.720977255
is version of: CHEBI:17794
boundary condition: false
constant: false
initial concentration: NaN
is: SBO:0000247
in compartment: metaid_0000209

metaid_0000167
constant: true
value: 1.3E-9
name: g_pdh_vpdhr_bound
type: Parameter

metaid_0000018
constant: true
value: 1.7E9
name: e_AceK_kcat_ph
type: Parameter

metaid_0000038
constant: true
value: 0.548
name: e_Akg2mal_Kakg
type: Parameter

metaid_0000203
constant: false
value: 0.0
name: k_bm_PEP
type: Parameter

781632
stoichiometry: 1.0
species: metaid_0000222
type: SpeciesReference

metaid_0000292
kinetic law: 782822
modifier: 782810
modifier: 782798
product: 782786
reactant: 782774
fast: false
reversible: false
name: e_Fdp
type: Reaction

metaid_0000187
constant: true
value: 0.049
name: bm_GLC_PG3
type: Parameter

metaid_0000117
constant: true
value: 1.0
name: tf_PdhR_n
type: Parameter

metaid_0000138
constant: true
value: 1.4E-6
name: g_akg2mal_vcrp_bound
type: Parameter

782251
stoichiometry: 1.0
species: metaid_0000252
type: SpeciesReference

metaid_0000168
constant: true
value: 0.0034
name: g_pdh_Kpdhr
type: Parameter

metaid_0000222
has only substance units: true
constant: false
is version of: C00074
is: SBO:0000247
in compartment: metaid_0000209
type: Species
name: PEP
boundary condition: false
initial concentration: NaN
is version of: CHEBI:18021
initial amount: 0.210455879

metaid_0000360
kinetic law: 786109
reactant: 786097
fast: false
reversible: false
name: d_EIIA_P
type: Reaction

metaid_0000019
constant: true
value: 2.0
name: e_AceK_n
type: Parameter

metaid_0000202
constant: false
value: 0.0
name: k_bm_OAA
type: Parameter

metaid_0000340
kinetic law: 785259
reactant: 785246
fast: false
reversible: false
name: d_CrpcAMP
type: Reaction

metaid_0000039
constant: true
value: 1000.0
name: e_CAMPdegr_kcat
type: Parameter

metaid_0000300
kinetic law: 783305
modifier: 783293
modifier: 783281
product: 783269
reactant: 783257
fast: false
reversible: false
name: e_Ppc
type: Reaction

metaid_0000293
reactant: 782834
name: e_GltA
modifier: 782883
modifier: 782871
reversible: false
fast: false
type: Reaction
kinetic law: 782895
product: 782859
reactant: 782847

781780
stoichiometry: 1.0
species: metaid_0000222
type: SpeciesReference

metaid_0000118
constant: true
value: 1.9E-9
name: g_aceBAK_vcra_unbound
type: Parameter

metaid_0000188
constant: true
value: 0.553
name: bm_GLC_PYR
type: Parameter

metaid_0000361
kinetic law: 786133
reactant: 786121
fast: false
reversible: false
name: d_EIICB
type: Reaction

metaid_0000016
constant: true
value: 0.719
name: e_AceB_Kglxacoa
type: Parameter

metaid_0000225
boundary condition: false
initial concentration: NaN
initial amount: 0.00472323
name: AceA
has only substance units: true
constant: false
is: SBO:0000014
type: Species
in compartment: metaid_0000209
is version of: P0A9G6

metaid_0000165
constant: true
value: 0.00535
name: g_pckA_Kcra
type: Parameter

metaid_0000139
constant: true
value: 0.091
name: g_akg2mal_Kcrp
type: Parameter

metaid_0000080
constant: true
value: 3.4
name: e_Pdh_L
type: Parameter

metaid_0000111
constant: true
value: 2.0
name: tf_Cra_n
type: Parameter

metaid_0000017
constant: true
value: 3.4E12
name: e_AceK_kcat_ki
type: Parameter

metaid_0000224
type: Species
in compartment: metaid_0000209
is: SBO:0000247
is version of: C00022
has only substance units: true
name: PYR
initial amount: 0.863278018
boundary condition: false
initial concentration: NaN
constant: false
is version of: CHEBI:32816

metaid_0000362
kinetic law: 786182
modifier: 786170
modifier: 786158
reactant: 786146
fast: false
reversible: false
name: d_ACoA
type: Reaction

metaid_0000290
kinetic law: 782714
modifier: 782702
product: 782690
reactant: 782677
fast: false
reversible: true
name: e_Emp
type: Reaction

metaid_0000166
constant: true
value: 3.6E-7
name: g_pdh_vpdhr_unbound
type: Parameter

784648
stoichiometry: 1.0
species: metaid_0000244
type: SpeciesReference

metaid_0000112
constant: true
value: 1.0E8
name: tf_Crp_scale
type: Parameter

metaid_0000291
kinetic law: 782762
modifier: 782750
product: 782738
reactant: 782726
fast: false
reversible: true
name: e_Eno
type: Reaction

782677
stoichiometry: 0.5
species: metaid_0000216
type: SpeciesReference

533565
constant: true
units: metaid_0020382
value: 0.0
name: GLC_1
type: Parameter

metaid_0000363
kinetic law: 786231
modifier: 786219
modifier: 786207
reactant: 786195
fast: false
reversible: false
name: d_AKG
type: Reaction

metaid_0000014
constant: true
value: 0.95
name: e_AceB_Kglx
type: Parameter

metaid_0000227
name: AceK
type: Species
initial concentration: NaN
has only substance units: true
is version of: P11071
boundary condition: false
initial amount: 1.41697E-4
constant: false
is: SBO:0000014
in compartment: metaid_0000209

782591
stoichiometry: 1.0
species: metaid_0000215
type: SpeciesReference

metaid_0000163
constant: true
value: 0.0
name: g_pckA_vcra_unbound
type: Parameter

metaid_0000113
constant: true
value: 0.895
name: tf_Crp_kcamp
type: Parameter

785784
stoichiometry: 1.0
species: metaid_0000242
type: SpeciesReference

533568
constant: true
units: metaid_0020382
value: 3.0
name: GLC_2
type: Parameter

782967
stoichiometry: 1.0
species: metaid_0000220
type: SpeciesReference

783366
stoichiometry: 1.0
species: metaid_0000222
type: SpeciesReference

metaid_0000364
kinetic law: 786279
modifier: 786267
modifier: 786255
reactant: 786243
fast: false
reversible: false
name: d_cAMP
type: Reaction

metaid_0000015
constant: true
value: 0.755
name: e_AceB_Kacoa
type: Parameter

metaid_0000226
initial amount: 0.001416969
constant: false
is: SBO:0000014
in compartment: metaid_0000209
boundary condition: false
type: Species
name: AceB
initial concentration: NaN
is version of: Q8X609
has only substance units: true

metaid_0000164
constant: true
value: 2.5E-6
name: g_pckA_vcra_bound
type: Parameter

metaid_0000114
constant: true
value: 1.0
name: tf_Crp_n
type: Parameter

533562
constant: true
units: metaid_0001382
value: 27.85
name: shift2
type: Parameter

metaid_0000305
type: Reaction
name: g_aceK
modifier: 783680
reversible: false
fast: false
modifier: 783704
product: 783644
modifier: 783692
kinetic law: 783740
modifier: 783668
modifier: 783656
modifier: 783716
modifier: 783728

metaid_0000181
constant: true
value: 1.8E-4
name: bm_muGLC
type: Parameter

metaid_0000248
constant: false
in compartment: metaid_0000209
type: Species
has part: CHEBI:16905
initial amount: 0.006990902
initial concentration: NaN
boundary condition: false
is: SBO:0000253
has part: P0ACP1
name: CraFBP
has only substance units: true

metaid_0000180
constant: true
value: 5.6E-5
name: bm_muACT
type: Parameter

metaid_0000161
constant: true
value: 9.1E-6
name: g_mdh_vcrp_bound
type: Parameter

metaid_0000229
has only substance units: true
constant: false
type: Species
name: Acs
initial concentration: NaN
initial amount: 0.001096222
boundary condition: false
is version of: P27550
is: SBO:0000014
in compartment: metaid_0000209

metaid_0000209
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

533561
constant: true
units: metaid_0001382
value: 8.15
name: shift1
type: Parameter

metaid_0000306
kinetic law: 783764
product: 783752
fast: false
reversible: false
name: g_acoa2act
type: Reaction

metaid_0000269
kinetic law: 781475
modifier: 781463
modifier: 781451
reactant: 781439
fast: false
reversible: false
name: bm_ACoA
type: Reaction

metaid_0000182
constant: true
value: 1.88
name: bm_GLC_ACoA
type: Parameter

metaid_0000249
boundary condition: false
is: SBO:0000245
is version of: P0ACJ8
initial amount: 0.005943273
has only substance units: true
initial concentration: NaN
name: Crp
constant: false
in compartment: metaid_0000209
type: Species

metaid_0000162
constant: true
value: 0.06
name: g_mdh_Kcrp
type: Parameter

metaid_0000228
is: SBO:0000014
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000209
name: Acoa2act
type: Species

metaid_0000208
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: Environment
type: Compartment

785833
stoichiometry: 1.0
species: metaid_0000252
type: SpeciesReference

781439
stoichiometry: 1.0
species: metaid_0000213
type: SpeciesReference

784064
stoichiometry: 1.0
species: metaid_0000234
type: SpeciesReference

metaid_0000307
kinetic law: 783824
modifier: 783812
modifier: 783800
modifier: 783788
product: 783776
fast: false
reversible: false
name: g_acs
type: Reaction

metaid_0000160
constant: true
value: 0.0
name: g_mdh_vcrp_unbound
type: Parameter

782542
stoichiometry: 1.0
species: metaid_0000214
type: SpeciesReference

785454
stoichiometry: 1.0
species: metaid_0000236
type: SpeciesReference

metaid_0000308
kinetic law: 783884
modifier: 783872
modifier: 783860
modifier: 783848
product: 783836
fast: false
reversible: false
name: g_akg2mal
type: Reaction

metaid_0000185
constant: true
value: 6.4
name: bm_GLC_OAA
type: Parameter

metaid_0000298
kinetic law: 783185
modifier: 783173
modifier: 783161
product: 783149
reactant: 783137
fast: false
reversible: false
name: e_Pdh
type: Reaction

metaid_0000119
constant: true
value: 2.0E-6
name: g_aceBAK_vcra_bound
type: Parameter

metaid_0000301
kinetic law: 783354
modifier: 783342
product: 783329
reactant: 783317
fast: false
reversible: false
name: e_PpsA
type: Reaction

metaid_0000205
constant: false
value: 0.0
name: k_bm_PYR
type: Parameter

782690
stoichiometry: 1.0
species: metaid_0000223
type: SpeciesReference

metaid_0000382
unit: 781391
name: seconds
type: SBMLUnitsDef

786339
stoichiometry: 1.0
species: metaid_0000217
type: SpeciesReference

metaid_0000244
name: Ppc
has only substance units: true
constant: false
in compartment: metaid_0000209
type: Species
initial concentration: NaN
is: SBO:0000014
boundary condition: false
initial amount: 9.99714E-4
is homolog to: Q9XHC7

metaid_0000186
constant: true
value: 0.423
name: bm_GLC_PEP
type: Parameter

metaid_0000204
constant: false
value: 0.0
name: k_bm_PG3
type: Parameter

metaid_0000302
kinetic law: 783414
modifier: 783402
modifier: 783390
product: 783378
reactant: 783366
fast: false
reversible: false
name: e_PykF
type: Reaction

metaid_0000299
kinetic law: 783245
modifier: 783233
modifier: 783221
product: 783209
reactant: 783197
fast: false
reversible: false
name: e_PfkA
type: Reaction

785857
stoichiometry: 1.0
species: metaid_0000253
type: SpeciesReference

783896
stoichiometry: 1.0
species: metaid_0000231
type: SpeciesReference

786633
stoichiometry: 1.0
species: metaid_0000223
type: SpeciesReference

metaid_0000245
name: PpsA
boundary condition: false
has only substance units: true
initial amount: 9.87493E-4
initial concentration: NaN
is: SBO:0000014
is version of: B5Z9Q0
constant: false
in compartment: metaid_0000209
type: Species

metaid_0000183
constant: true
value: 0.978
name: bm_GLC_AKG
type: Parameter

metaid_0000296
reactant: 783016
product: 783028
type: Reaction
name: e_Me
modifier: 783064
reversible: false
modifier: 783040
kinetic law: 783076
modifier: 783052
fast: false

metaid_0000303
product: 783426
modifier: 783474
modifier: 783510
name: g_aceA
reversible: false
modifier: 783498
fast: false
kinetic law: 783522
modifier: 783462
modifier: 783438
modifier: 783486
type: Reaction
modifier: 783450

metaid_0000207
constant: false
value: 0.0
name: SS_Ppc
type: Parameter

785298
stoichiometry: 1.0
species: metaid_0000233
type: SpeciesReference

781415
exponent: 1.0
scale: 0
multipler: 1.0
kind: GRAM
type: SBMLUnit

metaid_0000246
has only substance units: true
name: PykF
type: Species
initial concentration: NaN
in compartment: metaid_0000209
is version of: P0AD61
is: SBO:0000014
initial amount: 0.005977168
boundary condition: false
constant: false

metaid_0000184
constant: true
value: 0.154
name: bm_GLC_G6P
type: Parameter

metaid_0000297
kinetic law: 783124
modifier: 783112
product: 783100
reactant: 783088
fast: false
reversible: false
name: e_PckA
type: Reaction

782446
stoichiometry: 1.0
species: metaid_0000213
type: SpeciesReference

metaid_0000304
product: 783534
modifier: 783571
modifier: 783595
modifier: 783559
modifier: 783546
name: g_aceB
reversible: false
kinetic law: 783632
type: Reaction
modifier: 783583
modifier: 783619
fast: false
modifier: 783607

metaid_0000206
constant: false
value: 0.0
name: SS_Me
type: Parameter

metaid_0000247
in compartment: metaid_0000209
boundary condition: false
has only substance units: true
initial amount: 2.99098E-4
is: SBO:0000245
name: Cra
initial concentration: NaN
constant: false
is version of: P0ACP1
type: Species

metaid_0000253
name: PdhRPYR
boundary condition: false
initial amount: 0.006126187
in compartment: metaid_0000209
has only substance units: true
is part of: CHEBI:32816
is part of: P0ACM1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000253

786487
stoichiometry: 1.0
species: metaid_0000220
type: SpeciesReference

metaid_0000273
kinetic law: 781670
modifier: 781657
modifier: 781644
reactant: 781632
fast: false
reversible: false
name: bm_PEP
type: Reaction

782167
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

metaid_0000252
initial amount: 0.001163813
in compartment: metaid_0000209
is version of: P0ACM1
constant: false
boundary condition: false
is: SBO:0000245
has only substance units: true
type: Species
name: PdhR
initial concentration: NaN

metaid_0000272
kinetic law: 781620
modifier: 781608
modifier: 781596
reactant: 781584
fast: false
reversible: false
name: bm_OAA
type: Reaction

metaid_0000255
is part of: GO:0009401
has only substance units: true
type: Species
name: EIIA_P
is: SBO:0000014
is part of: P00550
in compartment: metaid_0000209
initial amount: 0.00352292
initial concentration: NaN
constant: false
boundary condition: false

782410
stoichiometry: 1.0
species: metaid_0000220
type: SpeciesReference

metaid_0000275
kinetic law: 781768
modifier: 781756
modifier: 781744
reactant: 781732
fast: false
reversible: false
name: bm_PYR
type: Reaction

metaid_0000254
initial amount: 0.09647707
constant: false
in compartment: metaid_0000209
is: SBO:0000014
is part of: GO:0009401
boundary condition: false
type: Species
name: EIIA
has only substance units: true
is part of: P00550
initial concentration: NaN

metaid_0000274
kinetic law: 781719
modifier: 781707
modifier: 781695
reactant: 781682
fast: false
reversible: false
name: bm_PG3
type: Reaction

782774
stoichiometry: 1.0
species: metaid_0000216
type: SpeciesReference

metaid_0000377
kinetic law: 786949
modifier: 786901
modifier: 786913
product: 786889
type: Reaction
name: env_ACTex
fast: false
reversible: false
modifier: 786937
modifier: 786925

786121
stoichiometry: 1.0
species: metaid_0000256
type: SpeciesReference

783269
stoichiometry: 1.0
species: metaid_0000221
type: SpeciesReference

metaid_0000068
constant: true
value: 10.1
name: e_Mdh_Kmal
type: Parameter

metaid_0000338
kinetic law: 785206
reactant: 785193
fast: false
reversible: false
name: d_CraFBP
type: Reaction

metaid_0000277
fast: false
product: 781864
is part of: GO:0009401
reactant: 781840
type: Reaction
product: 781852
is version of: GO:0006470
name: pts_r4
reversible: false
modifier: 781876
kinetic law: 781901
modifier: 781889

metaid_0000041
constant: true
value: 993.0
name: e_Cya_kcat
type: Parameter

metaid_0000378
unit: 781354
name: OD
type: SBMLUnitsDef

metaid_0000309
kinetic law: 783908
product: 783896
fast: false
reversible: false
name: g_cAMPdegr
type: Reaction

786731
stoichiometry: 1.0
species: metaid_0000210
type: SpeciesReference

782859
stoichiometry: 1.0
species: metaid_0000219
type: SpeciesReference

metaid_0000040
constant: true
value: 0.1
name: e_CAMPdegr_KcAMP
type: Parameter

metaid_0000337
kinetic law: 785180
reactant: 785167
fast: false
reversible: false
name: d_Cra
type: Reaction

metaid_0000069
constant: true
value: 1879.0
name: e_Me_kcat
type: Parameter

783209
stoichiometry: 1.0
species: metaid_0000216
type: SpeciesReference

metaid_0000276
is version of: GO:0006468
reversible: true
name: pts_r1
reactant: 781792
type: Reaction
product: 781804
product: 781816
kinetic law: 781828
reactant: 781780
is part of: GO:0009401
fast: false

metaid_0000379
unit: 781366
name: micromole
type: SBMLUnitsDef

metaid_0000251
type: Species
boundary condition: false
has only substance units: true
initial amount: 0.00729
initial concentration: NaN
in compartment: metaid_0000209
is: SBO:0000245
constant: false
is version of: P16528
name: IclR

781354
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

783329
stoichiometry: 1.0
species: metaid_0000222
type: SpeciesReference

metaid_0000279
fast: false
modifier: 782131
modifier: 782119
modifier: 782071
modifier: 782095
type: Reaction
modifier: 782083
kinetic law: 782143
name: e_AceK_Ph
product: 782059
is version of: GO:0006470
modifier: 782107
reactant: 782047
reversible: false

782628
stoichiometry: 1.0
species: metaid_0000215
type: SpeciesReference

metaid_0000066
constant: true
value: 773.0
name: e_Mdh_kcat
type: Parameter

metaid_0000250
initial amount: 0.001346727
is version of: P0ACJ8
constant: false
in compartment: metaid_0000209
name: CrpcAMP
type: Species
is version of: CHEBI:17489
initial concentration: NaN
boundary condition: false
has only substance units: true
is: SBO:0000253

781732
stoichiometry: 1.0
species: metaid_0000224
type: SpeciesReference

784441
stoichiometry: 1.0
species: metaid_0000241
type: SpeciesReference

786781
stoichiometry: 1.0
species: metaid_0000212
type: SpeciesReference

metaid_0000278
reversible: false
modifier: 782023
modifier: 782011
modifier: 781937
kinetic law: 782035
modifier: 781998
type: Reaction
modifier: 781974
modifier: 781962
modifier: 781986
fast: false
modifier: 781950
name: e_AceK_Ki
reactant: 781913
is version of: GO:0006468
product: 781925

785402
stoichiometry: 1.0
species: metaid_0000235
type: SpeciesReference

metaid_0000339
kinetic law: 785233
reactant: 785220
fast: false
reversible: false
name: d_Crp
type: Reaction

metaid_0000067
constant: true
value: 1.7
name: e_Mdh_n
type: Parameter

metaid_0000064
constant: true
value: 1.6E-4
name: e_Icd_Kict
type: Parameter

metaid_0000120
constant: true
value: 0.00365
name: g_aceBAK_Kcra
type: Parameter

metaid_0000045
constant: true
value: 5.92
name: e_Emp_Kfbp
type: Parameter

metaid_0000334
kinetic law: 785076
modifier: 785063
modifier: 785051
reactant: 785039
fast: false
reversible: false
name: d_Acs
type: Reaction

metaid_0000354
kinetic law: 785869
reactant: 785857
fast: false
reversible: false
name: d_PdhRPYR
type: Reaction

metaid_0000084
constant: true
value: 908000.0
name: e_PfkA_kcat
type: Parameter

metaid_0000140
constant: true
value: 0.74
name: g_akg2mal_n
type: Parameter

metaid_0000025
constant: true
value: 0.173
name: e_AceK_Koaa
type: Parameter

metaid_0000065
constant: true
value: 0.334
name: e_Icd_Kpep
type: Parameter

781925
stoichiometry: 1.0
species: metaid_0000238
type: SpeciesReference

metaid_0000333
kinetic law: 785026
reactant: 785013
fast: false
reversible: false
name: d_Acoa2act
type: Reaction

metaid_0000044
constant: true
value: 848.0
name: e_Emp_kcat_r
type: Parameter

784330
stoichiometry: 1.0
species: metaid_0000239
type: SpeciesReference

metaid_0000024
constant: true
value: 0.038
name: e_AceK_Kpyr
type: Parameter

metaid_0000353
kinetic law: 785845
reactant: 785833
fast: false
reversible: false
name: d_PdhR
type: Reaction

metaid_0000085
constant: true
value: 4.0
name: e_PfkA_n
type: Parameter

metaid_0000081
constant: true
value: 0.128
name: e_Pdh_Kpyr
type: Parameter

metaid_0000122
constant: true
value: 0.03
name: g_aceBAK_aceKfactor
type: Parameter

metaid_0000062
constant: true
value: 2.0
name: e_Icd_n
type: Parameter

metaid_0000043
constant: true
value: 1000.0
name: e_Emp_kcat_f
type: Parameter

metaid_0000336
kinetic law: 785154
reactant: 785141
fast: false
reversible: false
name: d_CAMPdegr
type: Reaction

782059
stoichiometry: 1.0
species: metaid_0000237
type: SpeciesReference

metaid_0000023
constant: true
value: 0.539
name: e_AceK_Kpep
type: Parameter

metaid_0000356
kinetic law: 785965
modifier: 785953
modifier: 785941
reactant: 785929
fast: false
reversible: false
name: d_Ppc
type: Reaction

786841
stoichiometry: 1.0
species: metaid_0000211
type: SpeciesReference

metaid_0000142
constant: true
value: 0.0
name: g_emp_vcra_bound
type: Parameter

metaid_0000082
constant: true
value: 0.231
name: e_Pdh_KpyrI
type: Parameter

metaid_0000121
constant: true
value: 0.3
name: g_aceBAK_aceBfactor
type: Parameter

metaid_0000063
constant: true
value: 127.0
name: e_Icd_L
type: Parameter

metaid_0000335
kinetic law: 785128
modifier: 785115
modifier: 785102
reactant: 785089
fast: false
reversible: false
name: d_Akg2mal
type: Reaction

metaid_0000042
constant: true
value: 0.0017
name: e_Cya_KEIIA
type: Parameter

metaid_0000355
kinetic law: 785917
modifier: 785905
modifier: 785893
reactant: 785881
fast: false
reversible: false
name: d_PfkA
type: Reaction

metaid_0000022
constant: true
value: 0.643
name: e_AceK_Kicd_P
type: Parameter

785687
stoichiometry: 1.0
species: metaid_0000240
type: SpeciesReference

782919
stoichiometry: 1.0
species: metaid_0000214
type: SpeciesReference

metaid_0000141
constant: true
value: 6.2E-7
name: g_emp_vcra_unbound
type: Parameter

metaid_0000083
constant: true
value: 0.218
name: e_Pdh_Kglx
type: Parameter

781864
stoichiometry: 1.0
species: metaid_0000254
type: SpeciesReference

metaid_0000049
constant: true
value: 4.76
name: e_Eno_Kpg3
type: Parameter

metaid_0000060
constant: true
value: 0.63
name: e_GltA_Kakg
type: Parameter

metaid_0000330
kinetic law: 784903
modifier: 784890
modifier: 784878
reactant: 784866
fast: false
reversible: false
name: d_AceA
type: Reaction

781816
stoichiometry: 1.0
species: metaid_0000255
type: SpeciesReference

metaid_0000088
constant: true
value: 0.138
name: e_PfkA_Kpep
type: Parameter

metaid_0000144
constant: true
value: 0.0
name: g_emp_vcrp_unbound
type: Parameter

metaid_0000358
kinetic law: 786061
modifier: 786049
modifier: 786037
reactant: 786025
fast: false
reversible: false
name: d_PykF
type: Reaction

metaid_0000021
constant: true
value: 0.043
name: e_AceK_Kicd
type: Parameter

782726
stoichiometry: 1.0
species: metaid_0000223
type: SpeciesReference

783137
stoichiometry: 1.0
species: metaid_0000224
type: SpeciesReference

metaid_0000061
constant: true
value: 695.0
name: e_Icd_kcat
type: Parameter

metaid_0000048
constant: true
value: 522.0
name: e_Eno_kcatr
type: Parameter

metaid_0000089
constant: true
value: 5635.0
name: e_Ppc_kcat
type: Parameter

metaid_0000143
constant: true
value: 0.09
name: g_emp_Kcra
type: Parameter

metaid_0000020
constant: true
value: 1.0E8
name: e_AceK_L
type: Parameter

metaid_0000357
kinetic law: 786013
modifier: 786001
modifier: 785989
reactant: 785977
fast: false
reversible: false
name: d_PpsA
type: Reaction

781487
stoichiometry: 1.0
species: metaid_0000214
type: SpeciesReference

metaid_0000332
kinetic law: 785001
modifier: 784989
modifier: 784977
reactant: 784964
fast: false
reversible: false
name: d_AceK
type: Reaction

785089
stoichiometry: 1.0
species: metaid_0000230
type: SpeciesReference

782834
stoichiometry: 1.0
species: metaid_0000213
type: SpeciesReference

metaid_0000271
kinetic law: 781572
modifier: 781559
modifier: 781547
reactant: 781535
fast: false
reversible: false
name: bm_G6P
type: Reaction

metaid_0000047
constant: true
value: 695.0
name: e_Eno_kcatf
type: Parameter

metaid_0000086
constant: true
value: 9.5E7
name: e_PfkA_L
type: Parameter

782301
stoichiometry: 1.0
species: metaid_0000219
type: SpeciesReference

metaid_0000230
is: SBO:0000014
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001026848
in compartment: metaid_0000209
name: Akg2mal
type: Species

782398
stoichiometry: 1.0
species: metaid_0000218
type: SpeciesReference

metaid_0000146
constant: true
value: 0.012
name: g_emp_Kcrp
type: Parameter

782215
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

metaid_0000331
kinetic law: 784952
modifier: 784940
modifier: 784927
reactant: 784915
fast: false
reversible: false
name: d_AceB
type: Reaction

metaid_0000046
constant: true
value: 16.6
name: e_Emp_Kpg3
type: Parameter

metaid_0000270
kinetic law: 781523
modifier: 781511
modifier: 781499
reactant: 781487
fast: false
reversible: false
name: bm_AKG
type: Reaction

metaid_0000087
constant: true
value: 0.022
name: e_PfkA_Kg6p
type: Parameter

metaid_0000159
constant: true
value: 0.00117
name: g_icd_Kcra
type: Parameter

783776
stoichiometry: 1.0
species: metaid_0000229
type: SpeciesReference

metaid_0000231
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000209
name: CAMPdegr
type: Species

metaid_0000145
constant: true
value: 4.7E-7
name: g_emp_vcrp_bound
type: Parameter

786073
stoichiometry: 1.0
species: metaid_0000254
type: SpeciesReference

784818
stoichiometry: 1.0
species: metaid_0000254
type: SpeciesReference

metaid_0000359
kinetic law: 786085
reactant: 786073
fast: false
reversible: false
name: d_EIIA
type: Reaction

metaid_0000211
name: ACT
substance units: gram
in compartment: metaid_0000208
type: Species
has only substance units: false
is version of: C00033
initial amount: 0.0
boundary condition: false
constant: false
initial concentration: NaN
is: SBO:0000247
is version of: CHEBI:15366

metaid_0000125
constant: true
value: 0.00301
name: g_aceBAK_KPprime
type: Parameter

metaid_0000155
constant: true
value: 0.04
name: g_gltA_Kcrp
type: Parameter

metaid_0000280
kinetic law: 782191
modifier: 782179
product: 782167
reactant: 782155
is version of: GO:0043234
fast: false
reversible: true
name: tf_Cra
type: Reaction

metaid_0000105
constant: true
value: 46.3
name: pts_km1
type: Parameter

metaid_0000175
constant: true
value: 3.9E-7
name: g_pykF_vcra_unbound
type: Parameter

metaid_0000311
kinetic law: 783956
product: 783944
fast: false
reversible: false
name: g_crp
type: Reaction

metaid_0000196
constant: false
value: 0.0
name: alphaGLC
type: Parameter

785929
stoichiometry: 1.0
species: metaid_0000244
type: SpeciesReference

785881
stoichiometry: 1.0
species: metaid_0000243
type: SpeciesReference

metaid_0000156
constant: true
value: 1.07
name: g_gltA_n
type: Parameter

metaid_0000126
constant: true
value: 0.00488
name: g_aceBAK_KG
type: Parameter

783644
stoichiometry: 1.0
species: metaid_0000227
type: SpeciesReference

metaid_0000210
constant: false
boundary condition: false
has only substance units: true
substance units: metaid_0000378
initial concentration: NaN
initial amount: 0.03
in compartment: metaid_0000208
name: BM
type: Species

metaid_0000281
kinetic law: 782239
modifier: 782227
product: 782215
reactant: 782203
is version of: GO:0043234
fast: false
reversible: true
name: tf_Crp
type: Reaction

metaid_0000106
constant: true
value: 2520.0
name: pts_k4
type: Parameter

metaid_0000176
constant: true
value: 2.1E-9
name: g_pykF_vcra_bound
type: Parameter

metaid_0000195
constant: true
value: 5.185
name: bm_ACT_PYR
type: Parameter

metaid_0000312
kinetic law: 783980
product: 783968
fast: false
reversible: false
name: g_cya
type: Reaction

metaid_0000157
constant: true
value: 1.1E-7
name: g_icd_vcra_unbound
type: Parameter

782326
stoichiometry: 1.0
species: metaid_0000218
type: SpeciesReference

metaid_0000123
constant: true
value: 2.19
name: g_aceBAK_KDNA
type: Parameter

metaid_0000177
constant: true
value: 0.0023
name: g_pykF_Kcra
type: Parameter

metaid_0000103
constant: true
value: 0.413
name: e_PykF_Kfbp
type: Parameter

metaid_0000282
kinetic law: 782288
modifier: 782275
product: 782263
reactant: 782251
is version of: GO:0043234
fast: false
reversible: true
name: tf_PdhR
type: Reaction

metaid_0000198
constant: false
value: 0.0
name: mu
type: Parameter

783968
stoichiometry: 1.0
species: metaid_0000232
type: SpeciesReference

metaid_0000158
constant: true
value: 8.5E-7
name: g_icd_vcra_bound
type: Parameter

782386
stoichiometry: 1.0
species: metaid_0000213
type: SpeciesReference

533577
constant: true
value: 0.03
name: BM_1
type: Parameter

metaid_0000124
constant: true
value: 0.897
name: g_aceBAK_KP
type: Parameter

metaid_0000283
kinetic law: 782374
product: 782326
modifier: 782362
product: 782314
modifier: 782338
is part of: R00267
modifier: 782350
reactant: 782301
type: Reaction
name: e_AceA
is part of: R00479
reversible: false
fast: false

metaid_0000104
constant: true
value: 116.0
name: pts_k1
type: Parameter

metaid_0000197
constant: false
value: 0.0
name: alphaACT
type: Parameter

metaid_0000310
kinetic law: 783932
product: 783920
fast: false
reversible: false
name: g_cra
type: Reaction

metaid_0000178
constant: true
value: 2.8E-5
name: d_k_degr
type: Parameter

metaid_0000151
constant: true
value: 4.5E-8
name: g_fdp_vcra_bound
type: Parameter

metaid_0000129
constant: true
value: 1.0
name: g_aceBAK_DNA
type: Parameter

783752
stoichiometry: 1.0
species: metaid_0000228
type: SpeciesReference

784185
stoichiometry: 1.0
species: metaid_0000236
type: SpeciesReference

metaid_0000026
constant: true
value: 0.866
name: e_AceK_Kglx
type: Parameter

metaid_0000351
kinetic law: 785772
modifier: 785760
modifier: 785748
reactant: 785736
fast: false
reversible: false
name: d_PckA
type: Reaction

metaid_0000012
constant: true
value: 0.827
name: e_AceA_Kakg
type: Parameter

metaid_0000191
constant: true
value: 0.076
name: bm_ACT_G6P
type: Parameter

metaid_0000215
is version of: CHEBI:17489
in compartment: metaid_0000209
has only substance units: true
name: cAMP
type: Species
initial concentration: NaN
initial amount: 0.202804098
is: SBO:0000247
boundary condition: false
constant: false
is version of: C00575

782979
stoichiometry: 1.0
species: metaid_0000221
type: SpeciesReference

metaid_0000179
constant: true
value: 20000.0
name: bm_k_expr
type: Parameter

metaid_0000192
constant: true
value: 1.43
name: bm_ACT_OAA
type: Parameter

metaid_0000090
constant: true
value: 3.0
name: e_Ppc_n
type: Parameter

metaid_0000101
constant: true
value: 100000.0
name: e_PykF_L
type: Parameter

metaid_0000013
constant: true
value: 47.8
name: e_AceB_kcat
type: Parameter

metaid_0000152
constant: true
value: 0.00118
name: g_fdp_Kcra
type: Parameter

metaid_0000214
boundary condition: false
is version of: CHEBI:16810
constant: false
initial concentration: NaN
type: Species
has only substance units: true
name: AKG
is: SBO:0000247
in compartment: metaid_0000209
is version of: C00026
initial amount: 0.191190619

metaid_0000352
kinetic law: 785821
modifier: 785809
modifier: 785797
reactant: 785784
fast: false
reversible: false
name: d_Pdh
type: Reaction

metaid_0000027
constant: true
value: 0.82
name: e_AceK_Kakg
type: Parameter

781792
stoichiometry: 1.0
species: metaid_0000254
type: SpeciesReference

metaid_0000190
constant: true
value: 0.056
name: bm_ACT_AKG
type: Parameter

metaid_0000102
constant: true
value: 5.0
name: e_PykF_Kpep
type: Parameter

metaid_0000127
constant: true
value: 923.0
name: g_aceBAK_L
type: Parameter

metaid_0000153
constant: true
value: 0.0
name: g_gltA_vcrp_unbound
type: Parameter

metaid_0000010
constant: true
value: 0.055
name: e_AceA_Kpep
type: Parameter

metaid_0000028
constant: true
value: 1.57
name: e_AceK_Kpg3
type: Parameter

metaid_0000213
is: SBO:0000247
initial concentration: NaN
name: ACoA
is version of: C00024
has only substance units: true
constant: false
initial amount: 0.351972298
type: Species
boundary condition: false
in compartment: metaid_0000209
is version of: CHEBI:15351

metaid_0000093
constant: true
value: 0.408
name: e_Ppc_Kfbp
type: Parameter

metaid_0000092
constant: true
value: 0.048
name: e_Ppc_Kpep
type: Parameter

783028
stoichiometry: 1.0
species: metaid_0000224
type: SpeciesReference

metaid_0000194
constant: true
value: 0.066
name: bm_ACT_PG3
type: Parameter

783944
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

787009
persistant: true
initial value: true
type: Trigger

784245
stoichiometry: 1.0
species: metaid_0000237
type: SpeciesReference

metaid_0000128
constant: true
value: 9.3E-4
name: g_aceBAK_kcat_iclr
type: Parameter

metaid_0000154
constant: true
value: 2.3E-6
name: g_gltA_vcrp_bound
type: Parameter

metaid_0000029
constant: true
value: 0.137
name: e_AceK_Kict
type: Parameter

metaid_0000011
constant: true
value: 0.72
name: e_AceA_Kpg3
type: Parameter

metaid_0000350
kinetic law: 785724
modifier: 785712
modifier: 785700
reactant: 785687
fast: false
reversible: false
name: d_Me
type: Reaction

metaid_0000212
boundary condition: false
initial concentration: NaN
name: GLC
constant: false
substance units: gram
initial amount: 4.8
is version of: C00293
is version of: CHEBI:17234
type: Species
is: SBO:0000247
in compartment: metaid_0000208
has only substance units: false

metaid_0000091
constant: true
value: 5200000.0
name: e_Ppc_L
type: Parameter

metaid_0000100
constant: true
value: 4.0
name: e_PykF_n
type: Parameter

metaid_0000193
constant: true
value: 0.047
name: bm_ACT_PEP
type: Parameter

783016
stoichiometry: 1.0
species: metaid_0000220
type: SpeciesReference

784306
stoichiometry: 1.0
species: metaid_0000251
type: SpeciesReference

785636
stoichiometry: 1.0
species: metaid_0000239
type: SpeciesReference

metaid_0000288
kinetic law: 782616
modifier: 782603
reactant: 782591
fast: false
reversible: false
name: e_CAMPdegr
type: Reaction

metaid_0000219
is: SBO:0000247
in compartment: metaid_0000209
constant: false
name: ICT
has only substance units: true
is version of: C00311
boundary condition: false
is version of: CHEBI:30887
type: Species
initial concentration: NaN
initial amount: 0.001408116

metaid_0000319
kinetic law: 784379
modifier: 784366
modifier: 784354
modifier: 784342
product: 784330
fast: false
reversible: false
name: g_mdh
type: Reaction

metaid_0000376
kinetic law: 786877
modifier: 786865
modifier: 786853
reactant: 786841
fast: false
reversible: false
name: env_ACTup
type: Reaction

W3 CDTF: Thu Sep 08 13:36:40 BST 2011

metaid_0000238
boundary condition: false
initial concentration: NaN
initial amount: 2.20477E-4
has only substance units: true
is: SBO:0000014
constant: false
name: Icd_P
is version of: P08200
in compartment: metaid_0000209
type: Species

783378
stoichiometry: 1.0
species: metaid_0000224
type: SpeciesReference

metaid_0000289
kinetic law: 782665
modifier: 782653
modifier: 782640
product: 782628
fast: false
reversible: false
name: e_Cya
type: Reaction

785193
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

786291
stoichiometry: 1.0
species: metaid_0000216
type: SpeciesReference

533571
constant: true
units: metaid_0020382
value: 5.0
name: ACT_1
type: Parameter

metaid_0000218
initial amount: 5.70593E-9
has only substance units: true
type: Species
name: GLX
is version of: C00048
boundary condition: false
is: SBO:0000247
initial concentration: NaN
constant: false
is version of: CHEBI:16891
in compartment: metaid_0000209

metaid_0000375
kinetic law: 786829
modifier: 786817
modifier: 786805
modifier: 786793
reactant: 786781
fast: false
reversible: false
name: env_GLCup
type: Reaction

metaid_0000239
type: Species
has only substance units: true
in compartment: metaid_0000209
name: Mdh
is: SBO:0000014
constant: false
initial amount: 0.00345727
is version of: P61889
boundary condition: false
initial concentration: NaN

533426
event assignment: 787045
event assignment: 787033
event assignment: 787021
trigger: 787009
use values from trigger time: true
name: second shift
type: Event

metaid_0000256
in compartment: metaid_0000209
is: SBO:0000014
has only substance units: true
type: Species
initial amount: 0.003
initial concentration: NaN
boundary condition: false
name: EIICB
is part of: GO:0009401
constant: false
is part of: P00550

metaid_0000317
kinetic law: 784294
modifier: 784282
modifier: 784269
modifier: 784257
product: 784245
fast: false
reversible: false
name: g_icd
type: Reaction

metaid_0000217
in compartment: metaid_0000209
is version of: CHEBI:14314
constant: false
is version of: C00092
boundary condition: false
type: Species
initial concentration: NaN
name: G6P
initial amount: 1.908140784
is: SBO:0000247
has only substance units: true

533425
event assignment: 786997
event assignment: 786985
event assignment: 786973
trigger: 786961
use values from trigger time: true
name: first shift
type: Event

metaid_0000374
kinetic law: 786768
modifier: 786756
modifier: 786743
product: 786731
fast: false
reversible: false
name: env_growth
type: Reaction

metaid_0000236
initial concentration: NaN
is: SBO:0000014
constant: false
boundary condition: false
type: Species
is version of: P0ABH7
initial amount: 0.001029612
name: GltA
has only substance units: true
in compartment: metaid_0000209

metaid_0000170
constant: true
value: 6.6E-9
name: g_pfkA_vcra_bound
type: Parameter

786387
stoichiometry: 1.0
species: metaid_0000218
type: SpeciesReference

metaid_0000318
kinetic law: 784318
product: 784306
fast: false
reversible: false
name: g_iclr
type: Reaction

metaid_0000216
has only substance units: true
initial amount: 6.57504207
is version of: CHEBI:16905
type: Species
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000209
is: SBO:0000247
is version of: C00354
name: FBP
constant: false

metaid_0000237
in compartment: metaid_0000209
name: Icd
type: Species
has only substance units: true
initial amount: 0.004290789
is version of: P08200
is: SBO:0000014
constant: false
boundary condition: false
initial concentration: NaN

metaid_0000373
kinetic law: 786719
modifier: 786706
modifier: 786694
reactant: 786682
fast: false
reversible: false
name: d_PYR
type: Reaction

784503
stoichiometry: 1.0
species: metaid_0000242
type: SpeciesReference

metaid_0000150
constant: true
value: 0.0
name: g_fdp_vcra_unbound
type: Parameter

W3 CDTF: Sun Mar 14 23:34:51 GMT 2010

metaid_0000315
kinetic law: 784172
modifier: 784160
modifier: 784148
modifier: 784136
product: 784124
fast: false
reversible: false
name: g_fdp
type: Reaction

781535
stoichiometry: 1.0
species: metaid_0000217
type: SpeciesReference

metaid_0000171
constant: true
value: 6.3E-7
name: g_pfkA_Kcra
type: Parameter

784915
stoichiometry: 1.0
species: metaid_0000226
type: SpeciesReference

metaid_0000284
fast: false
type: Reaction
name: e_AceB
is version of: R00472
reversible: false
product: 782410
reactant: 782398
kinetic law: 782434
modifier: 782422
reactant: 782386

metaid_0000109
constant: true
value: 100.0
name: tf_Cra_scale
type: Parameter

metaid_0000234
initial amount: 0.011552813
boundary condition: false
is version of: P0A6P9
is: SBO:0000014
has only substance units: true
constant: false
name: Eno
initial concentration: NaN
in compartment: metaid_0000209
type: Species

metaid_0000372
kinetic law: 786670
modifier: 786658
modifier: 786646
reactant: 786633
fast: false
reversible: false
name: d_PG3
type: Reaction

783534
stoichiometry: 1.0
species: metaid_0000226
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786146
stoichiometry: 1.0
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781427
exponent: -1.0
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type: SBMLUnit

metaid_0000316
kinetic law: 784233
modifier: 784221
modifier: 784209
modifier: 784197
product: 784185
fast: false
reversible: false
name: g_gltA
type: Reaction

metaid_0000199
constant: false
value: 0.0
name: k_bm_ACoA
type: Parameter

786436
stoichiometry: 1.0
species: metaid_0000219
type: SpeciesReference

metaid_0000172
constant: true
value: 0.0
name: g_ppsA_vcra_unbound
type: Parameter

metaid_0000285
kinetic law: 782482
modifier: 782470
modifier: 782458
reactant: 782446
is version of: R00227
fast: false
reversible: false
name: e_Acoa2act
type: Reaction

782554
stoichiometry: 1.0
species: metaid_0000220
type: SpeciesReference

785506
stoichiometry: 1.0
species: metaid_0000237
type: SpeciesReference

784392
stoichiometry: 1.0
species: metaid_0000240
type: SpeciesReference

metaid_0000235
boundary condition: false
is homolog to: P00637
in compartment: metaid_0000209
initial amount: 1.57492E-4
has only substance units: true
is: SBO:0000014
constant: false
initial concentration: NaN
name: Fdp
type: Species

781584
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species: metaid_0000221
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metaid_0000371
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modifier: 786597
reactant: 786584
fast: false
reversible: false
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type: Reaction

785246
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

781378
exponent: 1.0
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multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000313
fast: false
kinetic law: 784052
type: Reaction
name: g_emp
modifier: 784004
reversible: false
modifier: 784016
product: 783992
modifier: 784028
modifier: 784040

metaid_0000286
kinetic law: 782530
modifier: 782518
modifier: 782506
product: 782494
fast: false
reversible: false
name: e_Acs
type: Reaction

metaid_0000107
constant: true
value: 0.0085
name: pts_KEIIA
type: Parameter

metaid_0000173
constant: true
value: 3.3E-6
name: g_ppsA_vcra_bound
type: Parameter

metaid_0000370
kinetic law: 786572
modifier: 786560
modifier: 786548
reactant: 786535
fast: false
reversible: false
name: d_OAA
type: Reaction

785610
stoichiometry: 1.0
species: metaid_0000251
type: SpeciesReference

metaid_0000232
initial amount: 0.001
constant: false
type: Species
is version of: P00936
boundary condition: false
name: Cya
in compartment: metaid_0000209
initial concentration: NaN
has only substance units: true
is: SBO:0000014

533574
constant: true
units: metaid_0020382
value: 3.0
name: ACT_2
type: Parameter

786961
persistant: true
initial value: true
type: Trigger

metaid_0000314
kinetic law: 784112
modifier: 784100
modifier: 784088
modifier: 784076
product: 784064
fast: false
reversible: false
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type: Reaction

metaid_0000108
constant: true
value: 0.0012
name: pts_Kglc
type: Parameter

metaid_0000174
constant: true
value: 0.017
name: g_ppsA_Kcra
type: Parameter

metaid_0000287
kinetic law: 782579
modifier: 782567
product: 782554
reactant: 782542
fast: false
reversible: false
name: e_Akg2mal
type: Reaction

metaid_0000233
is: SBO:0000014
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.011515593
in compartment: metaid_0000209
name: Emp
type: Species

781840
stoichiometry: 1.0
species: metaid_0000255
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metaid_0000243
in compartment: metaid_0000209
name: PfkA
initial concentration: NaN
is: SBO:0000014
is version of: P06999
type: Species
boundary condition: false
initial amount: 1.43816E-4
has only substance units: true
constant: false

metaid_0000242
constant: false
in compartment: metaid_0000209
name: Pdh
boundary condition: false
is version of: P0AFG8
has only substance units: true
is: SBO:0000014
type: Species
initial amount: 0.004647401
initial concentration: NaN

782494
stoichiometry: 1.0
species: metaid_0000213
type: SpeciesReference

BIOMD0000000244
parameter: metaid_0000091
reaction: metaid_0000376
parameter: metaid_0000117
parameter: metaid_0000202
parameter: metaid_0000062
reaction: metaid_0000365
parameter: metaid_0000124
parameter: metaid_0000078
rule: metaid_0000267
parameter: metaid_0000163
has version: GO:0006083
parameter: metaid_0000060
notes: This is the model described in: Bacterial adaptation through distributed sensing of metabolic fluxes Oliver Kotte, Judith B Zaugg and Matthias Heinemann; Mol Sys Biol 2010; 6 :355. doi: 10.1038/msb.2010.10 ; Abstract: The recognition of carbon sources and the regulatory adjustments to recognized changes are of particular importance for bacterial survival in fluctuating environments. Despite a thorough knowledge base of Escherichia coli's central metabolism and its regulation, fundamental aspects of the employed sensing and regulatory adjustment mechanisms remain unclear. In this paper, using a differential equation model that couples enzymatic and transcriptional regulation of E. coli's central metabolism, we show that the interplay of known interactions explains in molecular-level detail the system-wide adjustments of metabolic operation between glycolytic and gluconeogenic carbon sources. We show that these adaptations are enabled by an indirect recognition of carbon sources through a mechanism we termed distributed sensing of intracellular metabolic fluxes. This mechanism uses two general motifs to establish flux-signaling metabolites, whose bindings to transcription factors form flux sensors. As these sensors are embedded in global feedback loop architectures, closed-loop self-regulation can emerge within metabolism itself and therefore, metabolic operation may adapt itself autonomously (not requiring upstream sensing and signaling) to fluctuating carbon sources. In its current form this SBML model is parametrized for the glucose to acetate transition and to simulate the extended diauxic shift as shown in figure 3 and scenario 6 of the attached matlab file. In this scenario the cells first are grown from an OD600 (BM) of 0.03 with a starting glucose concentration of 0.5 g/l for 8.15 h (29340 sec). Then a medium containing 5 g/l acetate is inoculated with these cells to an OD600 of 0.03 and grown for another 19.7 hours (70920 sec). Finally the cells are shifted t…
parameter: metaid_0000179
parameter: metaid_0000076
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parameter: 533565
parameter: metaid_0000161
rule: metaid_0000265
reaction: metaid_0000272
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parameter: metaid_0000182
parameter: metaid_0000109
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species: metaid_0000234
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parameter: metaid_0000114
has version: GO:0008965
parameter: metaid_0000068
reaction: metaid_0000290
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is version of: GO:0010906
parameter: metaid_0000169
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parameter: metaid_0000121
species: metaid_0000235
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parameter: 533562
parameter: metaid_0000089
parameter: metaid_0000174
has version: GO:0006094
reaction: metaid_0000333
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parameter: metaid_0000142
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reaction: metaid_0000282
reaction: metaid_0000312
reaction: metaid_0000354
parameter: metaid_0000207

786195
stoichiometry: 1.0
species: metaid_0000214
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782786
stoichiometry: 1.0
species: metaid_0000217
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metaid_0000369
kinetic law: 786523
modifier: 786511
modifier: 786499
reactant: 786487
fast: false
reversible: false
name: d_MAL
type: Reaction

metaid_0000241
is homolog to: Q8GH15
constant: false
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is: SBO:0000014
initial amount: 0.002290892
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784588
stoichiometry: 1.0
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783992
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783257
stoichiometry: 1.0
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783197
stoichiometry: 1.0
species: metaid_0000217
type: SpeciesReference

metaid_0000240
initial amount: 9.99714E-4
name: Me
in compartment: metaid_0000209
constant: false
boundary condition: false
has only substance units: true
is version of: P76558
type: Species
is: SBO:0000014
initial concentration: NaN

metaid_0000349
kinetic law: 785675
modifier: 785662
modifier: 785649
reactant: 785636
fast: false
reversible: false
name: d_Mdh
type: Reaction

782155
stoichiometry: 1.0
species: metaid_0000247
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781804
stoichiometry: 1.0
species: metaid_0000224
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786584
stoichiometry: 1.0
species: metaid_0000222
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metaid_0000329
kinetic law: 784854
product: 784842
fast: false
reversible: false
name: g_EIICB
type: Reaction

781403
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

782847
stoichiometry: 1.0
species: metaid_0000221
type: SpeciesReference

781366
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0001382
unit: 781403
name: hours
type: SBMLUnitsDef

783317
stoichiometry: 1.0
species: metaid_0000224
type: SpeciesReference

metaid_0000367
kinetic law: 786424
modifier: 786412
modifier: 786399
reactant: 786387
fast: false
reversible: false
name: d_GLX
type: Reaction

metaid_0000078
constant: true
value: 1179.0
name: e_Pdh_kcat
type: Parameter

785977
stoichiometry: 1.0
species: metaid_0000245
type: SpeciesReference

metaid_0000328
kinetic law: 784830
product: 784818
fast: false
reversible: false
name: g_EIIA
type: Reaction

metaid_0000051
constant: true
value: 192.0
name: e_Fdp_kcat
type: Parameter

785013
stoichiometry: 1.0
species: metaid_0000228
type: SpeciesReference

533580
constant: true
value: 5.0E-4
name: BM_2
type: Parameter

metaid_0000368
kinetic law: 786474
modifier: 786461
modifier: 786448
reactant: 786436
fast: false
reversible: false
name: d_ICT
type: Reaction

785167
stoichiometry: 1.0
species: metaid_0000247
type: SpeciesReference

metaid_0000079
constant: true
value: 2.65
name: e_Pdh_n
type: Parameter

metaid_0000327
kinetic law: 784806
modifier: 784794
modifier: 784782
modifier: 784770
product: 784758
fast: false
reversible: false
name: g_pykF
type: Reaction

metaid_0000050
constant: true
value: 1.11
name: e_Eno_Kpep
type: Parameter

785039
stoichiometry: 1.0
species: metaid_0000229
type: SpeciesReference

786682
stoichiometry: 1.0
species: metaid_0000224
type: SpeciesReference

metaid_0000365
kinetic law: 786327
modifier: 786315
modifier: 786303
reactant: 786291
fast: false
reversible: false
name: d_FBP
type: Reaction

metaid_0020382
unit: 781427
unit: 781415
name: gram_per_litre
type: SBMLUnitsDef

metaid_0000326
kinetic law: 784746
modifier: 784734
modifier: 784721
modifier: 784709
product: 784697
fast: false
reversible: false
name: g_ppsA
type: Reaction

metaid_0000053
constant: true
value: 4000000.0
name: e_Fdp_L
type: Parameter

783100
stoichiometry: 1.0
species: metaid_0000222
type: SpeciesReference

metaid_0000366
kinetic law: 786375
modifier: 786363
modifier: 786351
reactant: 786339
fast: false
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name: d_G6P
type: Reaction

785350
stoichiometry: 1.0
species: metaid_0000234
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784697
stoichiometry: 1.0
species: metaid_0000245
type: SpeciesReference

metaid_0000052
constant: true
value: 4.0
name: e_Fdp_n
type: Parameter

metaid_0000325
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modifier: 784672
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product: 784648
fast: false
reversible: false
name: g_ppc
type: Reaction

metaid_0000055
constant: true
value: 0.3
name: e_Fdp_Kpep
type: Parameter

metaid_0000324
kinetic law: 784636
modifier: 784624
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modifier: 784600
product: 784588
fast: false
reversible: false
name: g_pfkA
type: Reaction

metaid_0000110
constant: true
value: 1.36
name: tf_Cra_kfbp
type: Parameter

metaid_0000074
constant: true
value: 6.54
name: e_Me_Kcamp
type: Parameter

metaid_0000130
constant: true
value: 2.3E-10
name: g_aceBAK_vcrp_bound
type: Parameter

metaid_0000035
constant: true
value: 340.0
name: e_Acs_kcat
type: Parameter

metaid_0000094
constant: true
value: 1.32
name: e_PpsA_kcat
type: Parameter

metaid_0000344
kinetic law: 785441
modifier: 785428
modifier: 785415
reactant: 785402
fast: false
reversible: false
name: d_Fdp
type: Reaction

782047
stoichiometry: 1.0
species: metaid_0000238
type: SpeciesReference

metaid_0000005
constant: true
value: 9.5E-7
name: env_uc
type: Parameter

785736
stoichiometry: 1.0
species: metaid_0000241
type: SpeciesReference

783426
stoichiometry: 1.0
species: metaid_0000225
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metaid_0000054
constant: true
value: 0.003
name: e_Fdp_Kfbp
type: Parameter

metaid_0000323
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product: 784564
fast: false
reversible: false
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783920
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species: metaid_0000247
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784842
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metaid_0000075
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name: e_PckA_kcat
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metaid_0000095
constant: true
value: 2.0
name: e_PpsA_n
type: Parameter

metaid_0000343
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reversible: false
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type: Reaction

metaid_0000034
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name: e_Acoa2act_Kpyr
type: Parameter

metaid_0000004
constant: true
value: 180.156
name: env_M_GLC
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782907
stoichiometry: 1.0
species: metaid_0000219
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785141
stoichiometry: 1.0
species: metaid_0000231
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metaid_0000322
kinetic law: 784552
modifier: 784540
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modifier: 784515
product: 784503
fast: false
reversible: false
name: g_pdh
type: Reaction

metaid_0000057
constant: true
value: 0.029
name: e_GltA_Koaa
type: Parameter

metaid_0000076
constant: true
value: 0.184
name: e_PckA_Koaa
type: Parameter

metaid_0000037
constant: true
value: 1530.0
name: e_Akg2mal_kcat
type: Parameter

metaid_0000096
constant: true
value: 1.0E-79
name: e_PpsA_L
type: Parameter

metaid_0000342
kinetic law: 785337
modifier: 785324
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reactant: 785298
fast: false
reversible: false
name: d_Emp
type: Reaction

metaid_0000003
constant: true
value: 60.05
name: env_M_ACT
type: Parameter

783836
stoichiometry: 1.0
species: metaid_0000230
type: SpeciesReference

metaid_0000056
constant: true
value: 1614.0
name: e_GltA_kcat
type: Parameter

metaid_0000321
kinetic law: 784491
modifier: 784478
modifier: 784466
modifier: 784454
product: 784441
fast: false
reversible: false
name: g_pckA
type: Reaction

metaid_0000077
constant: true
value: 1000.0
name: e_PckA_Kpep
type: Parameter

metaid_0000341
kinetic law: 785285
reactant: 785272
fast: false
reversible: false
name: d_Cya
type: Reaction

metaid_0000036
constant: true
value: 0.001
name: e_Acs_Kact
type: Parameter

metaid_0000097
constant: true
value: 0.00177
name: e_PpsA_Kpyr
type: Parameter

metaid_0000059
constant: true
value: 0.029
name: e_GltA_Koaaacoa
type: Parameter

metaid_0000320
kinetic law: 784429
modifier: 784417
modifier: 784404
product: 784392
fast: false
reversible: false
name: g_me
type: Reaction

metaid_0000009
constant: true
value: 0.022
name: e_AceA_Kict
type: Parameter

metaid_0000031
constant: true
value: 2.0
name: e_Acoa2act_n
type: Parameter

metaid_0000348
kinetic law: 785623
reactant: 785610
fast: false
reversible: false
name: d_IclR
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metaid_0000134
constant: true
value: 1.2E-6
name: g_acs_vcrp_bound
type: Parameter

785220
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

metaid_0000098
constant: true
value: 0.001
name: e_PpsA_Kpep
type: Parameter

metaid_0000148
constant: true
value: 0.0
name: g_eno_vcra_bound
type: Parameter

metaid_0000071
constant: true
value: 104000.0
name: e_Me_L
type: Parameter

metaid_0000058
constant: true
value: 0.212
name: e_GltA_Kacoa
type: Parameter

781391
exponent: 1.0
scale: 0
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kind: SECOND
type: SBMLUnit

782203
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

786889
stoichiometry: 1.0
species: metaid_0000211
type: SpeciesReference

metaid_0000008
constant: true
value: 50100.0
name: e_AceA_L
type: Parameter

metaid_0000347
kinetic law: 785597
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reactant: 785558
fast: false
reversible: false
name: d_Icd_P
type: Reaction

metaid_0000030
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name: e_Acoa2act_kcat
type: Parameter

785558
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species: metaid_0000238
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metaid_0000070
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name: e_Me_n
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metaid_0000133
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metaid_0000099
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name: e_PykF_kcat
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784866
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species: metaid_0000225
type: SpeciesReference

metaid_0000147
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value: 6.8E-7
name: g_eno_vcra_unbound
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metaid_0000072
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value: 0.00624
name: e_Me_Kmal
type: Parameter

783088
stoichiometry: 1.0
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785272
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species: metaid_0000232
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781852
stoichiometry: 1.0
species: metaid_0000217
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metaid_0000033
constant: true
value: 0.022
name: e_Acoa2act_Kacoa
type: Parameter

metaid_0000007
constant: true
value: 4.0
name: e_AceA_n
type: Parameter

metaid_0000346
kinetic law: 785545
modifier: 785532
modifier: 785519
reactant: 785506
fast: false
reversible: false
name: d_Icd
type: Reaction

metaid_0000132
constant: true
value: 0.341
name: g_aceBAK_Kcrp
type: Parameter

782263
stoichiometry: 1.0
species: metaid_0000253
type: SpeciesReference

metaid_0000073
constant: true
value: 3.64
name: e_Me_Kacoa
type: Parameter

784964
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species: metaid_0000227
type: SpeciesReference

784124
stoichiometry: 1.0
species: metaid_0000235
type: SpeciesReference

784758
stoichiometry: 1.0
species: metaid_0000246
type: SpeciesReference

783149
stoichiometry: 1.0
species: metaid_0000213
type: SpeciesReference

782738
stoichiometry: 1.0
species: metaid_0000222
type: SpeciesReference

781913
stoichiometry: 1.0
species: metaid_0000237
type: SpeciesReference

metaid_0000032
constant: true
value: 639000.0
name: e_Acoa2act_L
type: Parameter

metaid_0000345
kinetic law: 785493
modifier: 785480
modifier: 785467
reactant: 785454
fast: false
reversible: false
name: d_GltA
type: Reaction

metaid_0000006
constant: true
value: 614.0
name: e_AceA_kcat
type: Parameter

metaid_0000149
constant: true
value: 0.016
name: g_eno_Kcra
type: Parameter

metaid_0000131
constant: true
value: 2.0E-8
name: g_aceBAK_vcrp_unbound
type: Parameter

784564
stoichiometry: 1.0
species: metaid_0000252
type: SpeciesReference

orgname: EMBL-EBI

n:
  given: Lukas
  family: Endler